Cosmetic products and compositions comprising bioactive glass

Abstract

A cosmetic product, comprising: a vessel configured to contain a cosmetic composition; and a closing component configured to at least partially close the vessel; wherein the cosmetic composition is disposed within the vessel and comprises: a carrier; and a bioactive glass, comprising: 15-55 wt.% SiO2; 0.1-15 wt.% ZrO2; 20-60 wt.% CaO; and 5-30 wt.% P2O5. A method for preparing the cosmetic product comprises disposing the cosmetic composition into the vessel and at least partially closing the vessel with the closing component.

Description

COSMETIC PRODUCTS AND COMPOSITIONS COMPRISING BIOACTIVE GLASSCROSS-REFERENCE TO RELATED APPLICATION

[0001] This application claims the benefit of priority under 35 U.S.C. § 119 of U.S. Provisional Application Serial No. 63 / 673895 filed on July 22, 2024, the content of which is relied upon and incorporated herein by reference in its entirety.FIELD

[0002] This disclosure generally relates to cosmetic products, and more particularly to cosmetic products and cosmetic compositions that contain bioactive glasses for consumer and cosmetic applications.BACKGROUND

[0003] Cosmetics have become an integral part of daily routines worldwide, with a vast array of products catering to diverse skin types, tones, and personal preferences. Their popularity stems at least in part from their ability to enhance appearance, instill confidence, and address various skin concerns. However, despite the extensive range of existing products, there is a continuous demand for improvement.SUMMARY

[0004] In some aspects, disclosed is a cosmetic product comprising a cosmetic composition, the cosmetic composition comprising a carrier and a bioactive glass. In some aspects, the bioactive glass provides a sustained release of ions that contribute to beneficial properties, such as combating dermal aging through, for example, providing reparative, regenerative, anti-inflammatory, anti-aging, and / or antioxidant effect. Ions released may include, for example, silicon, silicate, phosphate, calcium, magnesium, or any combination thereof.

[0005] In some aspects, disclosed is a cosmetic product, comprising: a vessel configured to contain a cosmetic composition; and a closing component configured to at least partially close the vessel; wherein the cosmetic composition is disposed within the vessel and comprises: a carrier; and a bioactive glass. In some aspects, the bioactive glass comprises 15-55 wt.% SiCh; 0.1-15 wt.% ZrCU 20-60 wt.% CaO; and 5-30 wt.% P2O5.

[0006] In some, aspects, disclosed is a method for preparing a cosmetic product, the method comprising disposing a cosmetic composition into a vessel and at least partially closing the vessel with a closing component.

[0007] Additional features and advantages of the disclosure will be set forth in the detailed description which follows, and in part will be readily apparent to those skilled in the art from that description or recognized by practicing the aspects as described herein, including the detailed description which follows, the claims, as well as the appended drawings.

[0008] It is to be understood that both the foregoing general description and the following detailed description are merely exemplary and are intended to provide an overview or framework for understanding the nature and character of the disclosure and claims. The accompanying drawings are included to provide a further understanding of the disclosure and are incorporated into and constitute a part of this specification. The drawings illustrate various aspects of the disclosure and together with the description serve to explain the principles and operations of the various aspects.BRIEF DESCRIPTION OF THE DRAWINGS

[0009] The following detailed description can be further understood when read in conjunction with the following drawings. Whenever possible, the same reference numerals will be used throughout the drawings to refer to the same or like parts. It is to be understood that the figures are not drawn to scale and the size of each depicted component or the relative size of one component to another is not intended to be limiting.

[0010] FIG. 1 is a graph depicting calcium release kinetics in a simulated body fluid (artificial sweat) for a bioactive glass as disclosed herein (Example 1) as compared to a comparative glass (45S5) over 24 hr at 37°C.DETAILED DESCRIPTION

[0011] In the following description, whenever a group is described as comprising at least one of a group of elements and combinations thereof, it is understood that the group may comprise, consist essentially of, or consist of any number of those elements recited, either individually or in combination with each other. Similarly, whenever a group is described as consisting of at least one of a group of elements or combinations thereof, it is understood that the group may consist of any number of those elements recited, either individually or in combination with each other.

[0012] Where a range of numerical values is recited herein, comprising upper and lower values, unless otherwise stated in specific circumstances, the range is intended to include the endpoints thereof, and all integers and fractions within the range. Further, when an amount, concentration, or other value or parameter is given as a range, one or more ranges, or a list of upper values and lower values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or value and any lower range limit or value, regardless of whether such pairs are separately disclosed.

[0013] If the term “about” is used in describing a value or an end-point of a range, the disclosure should be understood to include the specific value or end-point referred to. As used herein, the term “about” means that amounts, sizes, formulations, parameters, and other quantities and characteristics are not and need not be exact, but may be approximate and / or larger or smaller, as desired, reflecting tolerances, conversion factors, rounding off, measurement error and the like, and other factors known to those of skill in the art. It is noted that the terms “substantially” may be utilized herein to represent the inherent degree of uncertainty that may be attributed to any quantitative comparison, value, measurement, or other representation. These terms are also utilized herein to represent the degree by which a quantitative representation may vary from a stated reference without resulting in a change in the basic function of the subject matter at issue. Thus, for example, a composition that is “free” or “essentially free” or “substantially free” of AI2O3 (or any other component) is one in which AI2O3 (or any other component) is not actively added or batched into the composition, but may be present in very small amounts as a contaminant (e.g., 500, 400, 300, 200, or 100 ppm or less).

[0014] As used herein, a glass, glass-ceramic, or crystalline phase that is “bioactive” means that the glass, glass-ceramic, or crystalline phase is biologically compatible with bone, teeth, and / or tissue. By way of illustration, in some aspects, “bioactive” in this context refers to (1) the ability to form apatite (or other bioactive crystalline phases such as hydroxyapatite, fluorapatite, carbonated apatite, or any combination thereof) in a simulated body fluid, such as artificial saliva, according to ASTM F1538-03 (2017), and / or (2) the capability of binding with a desired biological material (e.g., bones, teeth, and / or tissue). Generally, there is also an absence of toxicity or other significant negative effects in a biological environment (e.g., bones, teeth, and / or tissue).

[0015] Herein, bioactive glasses are expressed in terms of wt.% amounts of particular components included therein on an oxide bases unless otherwise indicated. Any component having more than one oxidation state may be present in a bioactive glass in any oxidation state. However, concentrations of such component are expressed in terms of the oxide in which such component is at its lowest oxidation state unless otherwise indicated.

[0016] A number of topical cosmetics and cosmeceuticals are readily available in the global market to treat aging or anti-inflammatory, although the results are less than satisfactory. Bioactive glasses (BAG) are of interest for cell proliferation abilities in wound healing applications. The regenerative potential of use of BAGs in cosmetic materials is of great interest due at least in part to the biologically-relevant ions that can be designed into BAGs and subsequently released over time once present on skin and / or hair. Such ions include, for example, silicon, silicate, phosphate, calcium, magnesium, or any combination thereof. Recent advances made in the understanding of the biochemical and molecular mechanisms of essential ions, i. e. calcium, magnesium, phosphate and silicon / silicate ions, with regard to dermal aging has given rise to new opportunities to exert these bioactive factors as promising cosmeceutical ingredients for the reparative, regenerative, anti-inflammatory, anti-aging, and / or antioxidant properties. Disclosed herein is a variety of cosmetic formulations utilizing water durable bioactive glass which manipulates the release rates of desired ions from silicate-based glass compositions that have demonstrated excellent biocompatibility. The disclosed bioactive glasses can serve as a desired regenerative agent, which extends the stability and efficacy in the exemplified cosmetic compositions. Such cosmetic compositions are of interest to applications in various topical cosmetics and cosmeceuticals.

[0017] Disclosed herein are cosmetic products containing cosmetic compositions, in which the cosmetic compositions comprise a bioactive glass. In some aspects, the bioactive glasses are compositions in silicate families that can release desired ions, in particular, calcium ions, that can benefit their application as a keystone component in cosmetic products. In some aspects, the release of calcium ions over a period of 24 hours suggests the capability of cell proliferation and regeneration in the exemplified cosmetic compositions. The bioactive glasses are environmentally friendly without any toxic heavy metal or bio-incompatible ingredients for cosmetic industry. In some aspects, the bioactive glasses in cosmetic compositions soothe and maintain healthy skin. In some aspects, bioactive glass are processed to a desired average particle size for intended cosmetic applications.

[0018] In some aspects, disclosed is a cosmetic product, comprising: a vessel configured to contain a cosmetic composition; and a closing component configured to at least partially close the vessel; wherein the cosmetic composition is disposed within the vessel and comprises: a carrier; and a bioactive glass, comprising:15-55 wt.% SiO2;0.1-15 wt.% ZrO2;20-60 wt.% CaO; and5-30 wt.% P2O5.

[0019] In some aspects, the cosmetic compositions comprise a carrier. In some aspects, the carrier comprises one or more of the following carrier components: a skin soothing agent, an emollient, a humectant, a mineral, an antioxidant, a sun filter, a rheology modifier, a preservative, an emulsifier, a stabilizer, a pigment, a texturizer, a diluent, or any combination thereof. Thus, the cosmetic compositions herein can comprise one or more of these ingredients. These ingredients typically are referred to herein either as a carrier component, or simply as part of the cosmetic composition, but both descriptions are accurate and are intended to cover the same concept. However, amounts of a given ingredient are typically disclosed with respect to the total weight of the cosmetic composition, rather than total weight of the carrier. In some aspects, the carrier comprises a skin soothing agent and an emollient. In some aspects, the carrier comprises a sun filter, and antioxidant, and a humectant. All other possible combinations of the disclosed carrier components are contemplated. It is important tonote that there can be overlap among these categories of carrier components in cosmetic compositions. A carrier component may serve multiple functions and thus fall into more than one category. For example, a certain carrier component may act as both an emollient and a humectant, contributing to skin hydration by both sealing in moisture and attracting additional moisture to the skin. Similarly, some minerals can also act as sun filters. Therefore, while these categories provide a useful framework for understanding the different roles of carrier components, they are not mutually exclusive and many components may straddle multiple categories. In this regard, if a given composition is disclosed to have both a humectant and an emollient, or both a mineral and a sun filter, then two different such components must be present. In other words, one component (e.g., an emollient) cannot be deemed to satisfy both the requirement for an emollient and the requirement for a humectant in the same composition.

[0020] In some aspects, the cosmetic compositions and / or carriers comprise one or more skin soothing agents. Skin soothing agents are category of carrier components that are known for their ability to calm and alleviate skin irritation. These agents can help to reduce redness, inflammation, and discomfort on the skin, providing a soothing effect. In some aspects, the skin soothing agent comprises botanic extracts, allantoin, bisabolol, colloidal oatmeal, panthenol, niacinamide, or any combination thereof. Botanic extracts are substances obtained from plants that have desirable properties for skincare. The botanic extracts can be extracted from various parts of the plant, such as the leaves, flowers, roots, or seeds. Examples include witch hazel extract (astringent and soothing), green tea extract (antioxidant and anti-inflammatory), and aloe vera extract (soothing and hydrating).

[0021] The cosmetic compositions and / or carriers can comprise the one or more skin soothing agents in any suitable amount, based on total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more skin soothing agents in an amount (wt.%) of 0, >0, at least 0.5, at least 1, at least 2, at least 4, at least 6, at least 8, at least 10, at least 12, at least 14, 16 or less, 14 or less, 12 or less, 10 or less, 8 or less, 6 or less, 4 or less, 2 or less, 1 or less, 0.5 or less, or any range formed therefrom, based on total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more skin soothing agents in an amount (wt.%) of 0-16, 0-14, 0-12, 0-10, 0-8, 0- 6, 0-4, 0-2, 0-1, 0-0.5, >0-16, >0-14, >0-12, >0-10, >0-8, >0-6, >0-4, >0-2, >0-1, >0-0.5, 0.5-16, 0.5- 14, 0.5-12, 0.5-10, 0.5-8, 0.5-6, 0.5-4, 0.5-2, 0.5-1, 1-16, 1-14, 1-12, 1-10, 1-8, 1-6, 1-4, 1-2, 2-16, 2- 14, 2-12, 2-10, 2-8, 2-6, 2-4, 4-16, 4-14, 4-12, 4-10, 4-8, 4-6, 6-16, 6-14, 6-12, 6-10, 6-8, 8-16, 8-14, 8-12, 8-10, 10-16, 10-14, 10-12, 12-16, 12-14, or 14-16, based on total weight of the cosmetic composition. In particular, in some aspects, the cosmetic compositions and / or carriers comprise the one or more skin soothing agents in an amount of 2-10 wt.%, 4-10 wt.%, or 4-12 wt.%, based on total weight of the cosmetic composition. In some aspects, the cosmetic composition and / or carrier is free of, or substantially free of, a skin soothing agent. The amounts herein may refer to a total amount ofall skin soothing agents present, or to any individual skin soothing agent, as may be specified for a given context.

[0022] In some aspects, the cosmetic compositions and / or carriers comprise one or more emollients. Emollients are a category of carrier components that help to soften and smooth the skin. They work by filling in the spaces between skin cells with lipids, creating a smooth surface. They also help to improve the skin's hydration levels by forming a protective layer that seals in moisture. In some aspects, the emollient comprises caprylic / capric triglycerides, cetyl alcohol, ceramide, phytosphiosine, squalene, seed oils, botanic extract oils, isohexadecane, isononyl isononanoate, stearalkonium hectorite, galactoarabinan, isoeicosane, hydrogenated polyisobutene, dimethicone, allantoin, niacinamide, jojoba oil, shea butter, avocado oil, argan oil, lanolin, petrolatum, mineral oil, isopropyl myristate, stearyl alcohol, myristyl myristate, or any combination thereof. Botanic extract oils are oils obtained from plants, often through a process of cold pressing or steam distillation. They can provide emollient and nourishing properties, and some may have specific benefits such as antiinflammatory or antioxidant effects. Examples include jojoba oil (similar to skin's natural sebum, moisturizing), rosehip oil (rich in vitamins A and C, can help with skin regeneration), and tea tree oil (antibacterial, often used for acne-prone skin).

[0023] The cosmetic compositions and / or carriers can comprise one or more emollients in any suitable amount, based on the total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more emollients in an amount (wt.%) of 0, >0, at least 0.5, at least 1, at least 5, at least 10, at least 15, at least 20, at least 25, at least 30, at least 35, at least 40, at least 45, 50 or less, 45 or less, 40 or less, 35 or less, 30 or less, 25 or less, 20 or less, 15 or less, 10 or less, 5 or less, 1 or less, 0.5 or less, or any range formed therefrom, based on total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more emollients in an amount (wt.%) of 0-50, 0-45, 0-40, 0-35, 0- 30, 0-25, 0-20, 0-15, 0-10, 0-5, 0-1, 0-0.5, >0-50, >0-45, >0-40, >0-35, >0-30, >0-25, >0-20, >0-15, >0-10, >0-5, >0-1, >0-0.5, 0.5-50, 0.5-45, 0.5-40, 0.5-35, 0.5-30, 0.5-25, 0.5-20, 0.5-15, 0.5-10, 0.5-5, 1-50, 1-45, 1-40, 1-35, 1-30, 1-25, 1-20, 1-15, 1-10, 1-5, 5-50, 5-45, 5-40, 5-35, 5-30, 5-25, 5-20, 5- 15, 5-10, 10-50, 10-45, 10-40, 10-35, 10-30, 10-25, 10-20, 10-15, 15-50, 15-45, 15-40, 15-35, 15-30, 15-25, 15-20, 20-50, 20-45, 20-40, 20-35, 20-30, 20-25, 25-50, 25-45, 25-40, 25-35, 25-30, 30-50, 30- 45, 30-40, 30-35, 35-50, 35-45, 35-40, 40-50, 40-45, or 45-50, based on total weight of the cosmetic composition. In particular, in some aspects, the cosmetic compositions and / or carriers comprise the one or more emollients in an amount of 1-15 wt.%, 5-15 wt.%, or 5-20 wt.%, based on total weight of the cosmetic composition. In some aspects, the cosmetic composition and / or carrier is free of, or substantially free of, an emollient. The amounts herein may refer to a total amount of all emollients present, or to any individual emollient, as may be specified for a given context.

[0024] In some aspects, the cosmetic compositions and / or carriers comprise one or more humectants. Humectants are a category of carrier components that attract and retain moisture in the skin. They work by drawing water from the deeper layers of the skin to the surface, and in humid conditions, they can also pull in moisture from the air. In some aspects, the humectant comprises sodium hyaluronate, saccharide isomerate, glycerin, sodium hyaluronate, sodium lauroyl lactylate, sorbitol, propylene glycol, urea, honey, butylene glycol, polyethylene glycol (PEG), lactic acid, sorbitol, or any combination thereof.

[0025] The cosmetic compositions and / or carriers can comprise one or more humectants in any suitable amount, based on the total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more humectants in an amount (wt.%) of 0, >0, at least 0.05, at least 0.1, at least 0.5, at least 1, at least 2, at least 3, at least 4, at least 5, at least 6, at least 8, at least 10, at least 12, at least 14, 15 or less, 14 or less, 12 or less, 10 or less, 8 or less, 6 or less, 5 or less, 4 or less, 3 or less, 2 or less, 1 or less, 0.5 or less, 0.1 or less, 0.05 or less, or any range formed therefrom, based on total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more humectants in an amount (wt.%) of 0-15, 0-14, 0-12, 0-10, 0-8, 0-6, 0-5, 0-4, 0-3, 0-2, 0-1, 0-0.5, 0-0.1, 0-0.05, >0-15, >0-14, >0-12, >0-10, >0-8, >0-6, >0-5, >0-4, >0-3, >0-2, >0-1, >0-0.5, >0-0.1, >0-0.05, 0.05-15, 0.05-14, 0.05-12, 0.05-10, 0.05-8, 0.05-6, 0.05-5, 0.05-4, 0.05-3, 0.05-2, 0.05-1, 0.1-15, 0.1-14, 0.1-12, 0.1-10, 0.1-8, 0.1-6, 0.1-5, 0.1-4, 0.1-3, 0.1-2, 0.5-15, 0.5-14, 0.5-12, 0.5-10, 0.5-8, 0.5-6, 0.5-5, 0.5-4, 0.5-3, 0.5-2, 1-15, 1-14, 1-12, 1-10, 1-8, 1-6, 1-5, 1-4, 1-3, 2-15, 2-14, 2-12, 2-10, 2-8, 2-6, 2-5, 2-4, 2-3, 3- 15, 3-14, 3-12, 3-10, 3-8, 3-6, 3-5, 3-4, 4-15, 4-14, 4-12, 4-10, 4-8, 4-6, 4-5, 5-15, 5-14, 5-12, 5-10, 5- 8, 5-6, 6-15, 6-14, 6-12, 6-10, 6-8, 8-15, 8-14, 8-12, 8-10, 10-15, 10-14, 10-12, 12-15, 12-14, or 14- 15, based on total weight of the cosmetic composition. In particular, in some aspects, the cosmetic compositions and / or carriers comprise the one or more humectants in an amount of 0.1-5 wt.%, 0.5-5 wt.%, or 1-5 wt.%, based on total weight of the cosmetic composition. In some aspects, the cosmetic composition and / or carrier is free of, or substantially free of, a humectant. The amounts herein may refer to a total amount of all humectants present, or to any individual humectant, as may be specified for a given context. When the cosmetic compositions comprise glycerin (also called glycerol) as a humectant, the glycerin may also be acting as a diluent (e.g., as a solvent). Generally, therefore, the glycerin does not get double -counted in terms of concentration as both as a humectant and as a solvent.

[0026] In some aspects, the cosmetic compositions and / or carriers comprise one or more minerals. Minerals are a category of carrier components that are inorganic substances occurring naturally in the earth. In cosmetics, minerals can serve various functions, such as acting as colorants, absorbents, bulking agents, or as part of sun filters. In some aspects, the mineral comprises magnesium chloride, calcium chloride, sodium chloride, potassium chloride, zinc chloride, or any combination thereof.

[0027] The cosmetic compositions and / or carriers can comprise one or more minerals in any suitable amount, based on the total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more minerals in an amount (wt.%) of 0, >0, at least 0.01, at least 0.05, at least 0.1, at least 0.25, at least 0.5, at least 0.75, at least 1, at least 1.25, at least 1.5, at least 1.75, 2 or less, 1.75 or less, 1.5 or less, 1.25 or less, 1 or less, 0.75 or less, 0.5 or less, 0.25 or less, 0.1 or less, 0.05 or less, 0.01 or less, or any range formed therefrom, based on total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more minerals in an amount (wt.%) of 0-2, 0-1.75, 0-1.5, 0-1.25, 0-1, 0-0.75, 0-0.5, 0-0.25, 0-0.1, 0-0.05, 0-0.01, >0-2, >0-1.75, >0-1.5, >0-1.25, >0-1, >0-0.75, >0- 0.5, >0-0.25, >0-0.1, >0-0.05, >0-0.01, 0.01-2, 0.01-1.75, 0.01-1.5, 0.01-1.25, 0.01-1, 0.01-0.75, 0.01- 0.5, 0.01-0.25, 0.01-0.1, 0.01-0.05, 0.05-2, 0.05-1.75, 0.05-1.5, 0.05-1.25, 0.05-1, 0.05-0.75, 0.05-0.5, 0.05-0.25, 0.05-0.1, 0.1-2, 0.1-1.75, 0.1-1.5, 0.1-1.25, 0.1-1, 0.1-0.75, 0.1-0.5, 0.1-0.25, 0.25-2, 0.25- 1.75, 0.25-1.5, 0.25-1.25, 0.25-1, 0.25-0.75, 0.25-0.5, 0.5-2, 0.5-1.75, 0.5-1.5, 0.5-1.25, 0.5-1, 0.5- 0.75, 0.75-2, 0.75-1.75, 0.75-1.5, 0.75-1.25, 0.75-1, 1-2, 1-1.75, 1-1.5, 1-1.25, 1.25-2, 1.25-1.75, 1.25- 1.5, 1.5-2, 1.5-1.75, or 1.75-2, based on total weight of the cosmetic composition. In particular, in some aspects, the cosmetic compositions and / or carriers comprise the one or more minerals in an amount of 0.1-1 wt.%, 0.5-1 wt.%, or 0.75-1 wt.%, based on total weight of the cosmetic composition. In some aspects, the cosmetic composition is free of, or substantially free of, a mineral. The amounts herein may refer to a total amount of all minerals present, or to any individual mineral, as may be specified for a given context.

[0028] In some aspects, the cosmetic compositions and / or carriers comprises one or more antioxidants. Antioxidants are a category of carrier components that help to protect the skin from oxidative damage caused by environmental stressors like UV radiation and pollution. Antioxidants in some aspects work by neutralizing harmful free radicals, thereby helping to prevent skin damage and premature aging. In some aspects, the antioxidant comprises vitamin E, provitamin B5, vitamin C, vitamin A, green tea extract, resveratrol, coenzyme Qio, lycopene, or any combination thereof.

[0029] The cosmetic compositions and / or carriers can comprise one or more antioxidants in any suitable amount, based on the total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more antioxidants in an amount (wt.%) of 0, >0, at least 0.01, at least 0.05, at least 0.1, at least 0.25, at least 0.5, at least 0.75, at least 1, at least 1.25, at least 1.5, at least 1.75, 2 or less, 1.75 or less, 1.5 or less, 1.25 or less, 1 or less, 0.75 or less, 0.5 or less, 0.25 or less, 0.1 or less, 0.05 or less, 0.01 or less, or any range formed therefrom, based on total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more antioxidants in an amount (wt.%) of 0-2, 0- 1.75, 0-1.5, 0-1.25, 0-1, 0-0.75, 0-0.5, 0-0.25, 0-0.1, 0-0.05, 0-0.01, >0-2, >0-1.75, >0-1.5, >0-1.25, >0-1, >0-0.75, >0-0.5, >0-0.25, >0-0.1, >0-0.05, >0-0.01, 0.01-2, 0.01-1.75, 0.01-1.5, 0.01-1.25, 0.01-1, 0.01-0.75, 0.01-0.5, 0.01-0.25, 0.01-0.1, 0.05-2, 0.05-1.75, 0.05-1.5, 0.05-1.25, 0.05-1, 0.05-0.75, 0.05-0.5, 0.05-0.25, 0.1-2, 0.1-1.75, 0.1-1.5, 0.1-1.25, 0.1-1, 0.1-0.75, 0.1-0.5, 0.1-0.25, 0.25-2, 0.25- 1.75, 0.25-1.5, 0.25-1.25, 0.25-1, 0.25-0.75, 0.5-2, 0.5-1.75, 0.5-1.5, 0.5-1.25, 0.5-1, 0.5-0.75, 0.75-2, 0.75-1.75, 0.75-1.5, 0.75-1.25, 0.75-1, 1-2, 1-1.75, 1-1.5, 1-1.25, 1.25-2, 1.25-1.75, 1.25-1.5, 1.5-2, 1.5-1.75, or 1.75-2, based on total weight of the cosmetic composition. In particular, in some aspects, the cosmetic compositions and / or carriers comprise the one or more antioxidants in an amount of 0.1- 1 wt.%, 0.5-1 wt.%, or 0.75-1 wt.%, based on total weight of the cosmetic composition. In some aspects, the cosmetic composition and / or carrier is free of, or substantially free of, an antioxidant. The amounts herein may refer to a total amount of all antioxidants present, or to any individual antioxidant, as may be specified for a given context.

[0030] In some aspects, the cosmetic compositions and / or carriers comprise one or more sun filters. Sun filters are a category of carrier components that help to protect the skin from the harmful effects of UV radiation. Sun filters can either absorb, reflect, block, or scatter UV rays, preventing them from penetrating the skin and causing damage. In some aspects, the sun filter comprises titanium dioxide, zinc oxide, avobenzone, octinoxate, octisalate, oxybenzone, homosalate, or any combination thereof.

[0031] The cosmetic compositions and / or carriers can comprise one or more sun filters in any suitable amount, based on the total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more sun filters in an amount (wt.%) of 0, >0, at least 0.5, at least 1, at least 2, at least 5, at least 10, at least 15, at least 20, at least 25, 30 or less, 25 or less, 20 or less, 15 or less, 10 or less, 5 or less, 2 or less, 1 or less, 0.5 or less, or any range formed therefrom, based on total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more sun filters in an amount (wt.%) of 0-30, 0-25, 0-20, 0-15, 0-10, 0-5, 0-2, 0-1, 0-0.5, >0-30, >0-25, >0-20, >0-15, >0-10, >0-5, >0-2, >0- 1, >0-0.5, 0.5-30, 0.5-25, 0.5-20, 0.5-15, 0.5-10, 0.5-5, 0.5-2, 0.5-1, 1-30, 1-25, 1-20, 1-15, 1-10, 1-5, 1-2, 2-30, 2-25, 2-20, 2-15, 2-10, 2-5, 5-30, 5-25, 5-20, 5-15, 5-10, 10-30, 10-25, 10-20, 10-15, 15-30, 15-25, 15-20, 20-30, 20-25, or 25-30, based on total weight of the cosmetic composition. In particular, in some aspects, the cosmetic compositions and / or carriers comprise the one or more sun fdters in an amount of 2-25 wt.%, 5-20 wt.%, or 1-10 wt.%, based on total weight of the cosmetic composition. In some aspects, the cosmetic composition and / or carrier is free of, or substantially free of, a sun fdter. The amounts herein may refer to a total amount of all sun filters present, or to any individual sun filter, as may be specified for a given context.

[0032] In some aspects, the cosmetic compositions and / or carriers comprises one or more rheology modifiers. Rheology modifiers are a category of carrier components that alter the flow properties of cosmetic compositions. They can influence the viscosity (e.g., thickness), spreadability, and texture of a product, enhancing its stability and performance. In some aspects, the rheology modifier compriseshydroxypropyl guar, cetyl palmitate, xanthan gum, botanic extract buffers, cetearyl alcohol, polysorbate 60, silica, alumina, PEG-30 dipolyhydroxystearate, wax, caprate, triheptanoin, dilinoleic acid, hydroxyethylcellulose, carbomer, acacia gum, carrageenan, agar, pectin, bentonite, montmorillonite, carboxymethylcellulose (CMC), or any combination thereof. Botanic extract buffers are substances derived from plants that can help to stabilize the pH of a cosmetic formulation. Maintaining an appropriate pH is in some aspects important for the product's effectiveness and the skin's or hair’s health. Examples might include citric acid (derived from citrus fruits) or lactic acid (found in some fruits and sugars, though it's often produced by bacterial fermentation for cosmetic use). These ingredients can help to ensure the product is at a pH that is compatible with the skin and allows the other ingredients to function effectively.

[0033] The cosmetic compositions and / or carriers can comprise one or more rheology modifiers in any suitable amount, based on the total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more rheology modifiers in an amount (wt.%) of 0, >0, at least 0.01, at least 0.05, at least 0.1, at least 0.5, at least 1, at least 2, at least 5, at least 10, at least 15, at least 20, 25 or less, 20 or less, 15 or less, 10 or less, 5 or less, 2 or less, 1 or less, 0.5 or less, 0.1 or less, 0.05 or less, 0.01 or less, or any range formed therefrom, based on total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more rheology modifiers in an amount (wt.%) of 0-25, 0-20, 0-15, 0-10, 0-5, 0-2, 0-1, 0-0.5, 0-0.1, 0-0.05, 0-0.01, >0-25, >0-20, >0-15, >0-10, >0-5, >0-2, >0-1, >0-0.5, >0- 0.1, >0-0.05, >0-0.01, 0.01-25, 0.01-20, 0.01-15, 0.01-10, 0.01-5, 0.01-2, 0.01-1, 0.01-0.5, 0.01-0.1, 0.01-0.05, 0.05-25, 0.05-20, 0.05-15, 0.05-10, 0.05-5, 0.05-2, 0.05-1, 0.05-0.5, 0.05-0.1, 0.1-25, 0.1- 20, 0.1-15, 0.1-10, 0.1-5, 0.1-2, 0.1-1, 0.1-0.5, 0.5-25, 0.5-20, 0.5-15, 0.5-10, 0.5-5, 0.5-2, 0.5-1, 1-25, 1-20, 1-15, 1-10, 1-5, 1-2, 2-25, 2-20, 2-15, 2-10, 2-5, 5-25, 5-20, 5-15, 5-10, 10-25, 10-20, 10-15, 15- 25, 15-20, or 20-25, based on total weight of the cosmetic composition. In particular, in some aspects, the cosmetic compositions and / or carriers comprise the one or more rheology modifiers in an amount of 0.1-10 wt.%, 0.5-10 wt.%, or 1-10 wt.%, based on total weight of the cosmetic composition. In some aspects, the cosmetic composition and / or carrier is free of, or substantially free of, a rheology modifier. The amounts herein may refer to a total amount of all rheology modifiers present, or to any individual rheology modifier, as may be specified for a given context.

[0034] In some aspects, the cosmetic compositions and / or carriers comprise one or more preservatives. Preservatives are a category of carrier components that help to prevent the growth of microorganisms such as bacteria and fungi in cosmetic products. They are desirable for maintaining the product's safety, efficacy, and shelf-life. In some aspects, the preservative comprises phenoxyethanol, sorbic acid, caprylyl glycol, 1,2-hexanediol, benzyl alcohol, behentrimonium methosulfate, dehydroacetic acid, ethylhexylglycerin, sodium benzoate, potassium sorbate,methylparaben, ethylparaben, propylparaben, DMDM hydantoin, quatemium-15, or any combination thereof.

[0035] The cosmetic compositions and / or carriers can comprise one or more preservatives in any suitable amount, based on the total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more preservatives in an amount (wt.%) of 0, >0, at least 0.01, at least 0.05, at least 0.1, at least 0.2, at least 0.4, at least 0.6, at least 0.8, at least 1, at least 1.2, at least 1.4, at least 1.6, at least 1.8, 2 or less, 1.8 or less, 1.6 or less, 1.4 or less, 1.2 or less, 1 or less, 0.8 or less, 0.6 or less, 0.4 or less, 0.2 or less, 0.1 or less, 0.05 or less, 0.01 or less, or any range formed therefrom, based on total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more preservatives in an amount (wt.%) of 0-2, 0-1.8, 0-1.6, 0-1.4, 0-1.2, 0-1, 0-0.8, 0-0.6, 0-0.4, 0-0.2, 0-0.1, 0-0.05, 0- 0.01, >0-2, >0-1.8, >0-1.6, >0-1.4, >0-1.2, >0-1, >0-0.8, >0-0.6, >0-0.4, >0-0.2, >0-0.1, >0-0.05, >0- 0.01, 0.01-2, 0.01-1.8, 0.01-1.6, 0.01-1.4, 0.01-1.2, 0.01-1, 0.01-0.8, 0.01-0.6, 0.01-0.4, 0.01-0.2, 0.01-0.1, 0.01-0.05, 0.05-2, 0.05-1.8, 0.05-1.6, 0.05-1.4, 0.05-1.2, 0.05-1, 0.05-0.8, 0.05-0.6, 0.05-0.4, 0.05-0.2, 0.05-0.1, 0.1-2, 0.1-1.8, 0.1-1.6, 0.1-1.4, 0.1-1.2, 0.1-1, 0.1-0.8, 0.1-0.6, 0.1-0.4, 0.1-0.2, 0.2-2, 0.2-1.8, 0.2-1.6, 0.2-1.4, 0.2-1.2, 0.2-1, 0.2-0.8, 0.2-0.6, 0.2-0.4, 0.4-2, 0.4-1.8, 0.4-1.6, 0.4-1.4, 0.4-1.2, 0.4-1, 0.4-0.8, 0.4-0.6, 0.6-2, 0.6-1.8, 0.6-1.6, 0.6-1.4, 0.6-1.2, 0.6-1, 0.6-0.8, 0.8-2, 0.8-1.8, 0.8-1.6, 0.8-1.4, 0.8-1.2, 0.8-1, 1-2, 1-1.8, 1-1.6, 1-1.4, 1-1.2, 1.2-2, 1.2-1.8, 1.2-1.6, 1.2-1.4, 1.4-2, 1.4-1.8, 1.4-1.6, 1.6-2, 1.6-1.8, or 1.8-2, based on total weight of the cosmetic composition. In particular, in some aspects, the cosmetic compositions and / or carriers comprise the one or more preservatives in an amount of 0.1-1 wt.%, 0.2-0.8 wt.%, 0.1-0.4 wt.%, 0.5-1 wt.%, or 0.8-1 wt.%, based on total weight of the cosmetic composition. In some aspects, the cosmetic composition and / or carrier is free of, or substantially free of, a preservative. The amounts herein may refer to a total amount of all preservatives present, or to any individual preservative, as may be specified for a given context.

[0036] In some aspects, the cosmetic compositions and / or carriers comprise one or more emulsifiers. Emulsifiers are a category of carrier components that help to provide a stable emulsion (e.g., by facilitating emulsification of oil and water phases in a formulation), creating a homogenous mixture. They are desirable in many types of cosmetic products, including creams and lotions. In some aspects, the emulsifier comprises cetearyl alcohol, cetearyl glucoside, ceteareth-20, behentrimonium methosulfate, behenyl alcohol, polyglyceryl-3 stearate, glyceryl stearate, sodium acrylate, isohexadecane, polysorbate 80, sodium lauroyl lactylate, lecithin, polyglyceryl-4 oleate, olive sedate, PEG-7 glyceryl monococoate, sorbitan stearate, polysorbate 20, polysorbate 40, sucrose laurate, lecithin, sodium stearoyl glutamate, glyceryl oleate citrate, or any combination thereof.

[0037] The cosmetic compositions and / or carriers can comprise one or more emulsifiers in any suitable amount, based on the total weight of the cosmetic composition. For example, in some aspects,the cosmetic compositions and / or carriers comprise the one or more emulsifiers in an amount (wt.%) of 0, >0, at least 0.1, at least 0.5, at least 1, at least 2, at least 3, at least 4, at least 5, at least 6, at least 8, at least 10, at least 12, 14 or less, 12 or less, 10 or less, 8 or less, 6 or less, 5 or less, 4 or less, 3 or less, 2 or less, 1 or less, 0.5 or less, 0.1 or less, or any range formed therefrom, based on total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more emulsifiers in an amount (wt.%) of 0-14, 0-12, 0-10, 0-8, 0-6, 0-5, 0-4, 0-3, 0-2, 0-1, 0-0.5, 0-0.1, >0-14, >0-12, >0-10, >0-8, >0-6, >0-5, >0-4, >0-3, >0-2, >0-1, >0-0.5, >0-0.1, 0.1-14, 0.1-12, 0.1-10, 0.1-8, 0.1-6, 0.1-5, 0.1-4, 0.1-3, 0.1-2, 0.1-1, 0.1-0.5, 0.5-14, 0.5-12, 0.5-10, 0.5-8, 0.5-6, 0.5-5, 0.5-4, 0.5-3, 0.5-2, 0.5-1, 1-14, 1-12, 1-10, 1-8, 1-6, 1-5, 1-4, 1-3, 1-2, 2-14, 2-12, 2-10, 2-8, 2-6, 2-5, 2-4, 2-3, 3-14, 3-12, 3-10, 3-8, 3-6, 3-5, 3-4, 4-14, 4-12, 4-10, 4-8, 4-6, 4-5, 5-14, 5-12, 5-10, 5-8, 5-6, 6-14, 6-12, 6-10, 6-8, 8-14, 8-12, 8-10, 10-14, 10-12, or 12-14, based on total weight of the cosmetic composition. In particular, in some aspects, the cosmetic compositions and / or carriers comprise the one or more emulsifiers in an amount of 1-8 wt.%, 2-8 wt.%, 3-6, or 3-8 wt.%, based on total weight of the cosmetic composition. In some aspects, the cosmetic composition and / or carrier is free of, or substantially free of, an emulsifier. The amounts herein may refer to a total amount of all emulsifiers present, or to any individual emulsifier, as may be specified for a given context.

[0038] In some aspects, the cosmetic compositions and / or carriers comprise one or more stabilizers. Stabilizers are a category of carrier components that help to maintain the consistency, texture, and longevity of a product. They can prevent separation or changes in the formulation over time, ensuring the product performs as expected for its entire shelf-life. In some aspects, the stabilizer comprises sodium gluconate, sodium citrate, potassium citrate, calcium gluconate, magnesium gluconate, or any combination thereof.

[0039] The cosmetic compositions and / or carriers can comprise one or more stabilizers in any suitable amount, based on the total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more stabilizers in an amount (wt.%) of 0, >0, at least 0.01, at least 0.05, at least 0.1, at least 0.2, at least 0.4, at least 0.6, at least 0.8, at least 1, at least 1.2, at least 1.4, at least 1.6, at least 1.8, 2 or less, 1.8 or less, 1.6 or less, 1.4 or less, 1.2 or less, 1 or less, 0.8 or less, 0.6 or less, 0.4 or less, 0.2 or less, 0.1 or less, 0.05 or less, 0.01 or less, or any range formed therefrom, based on total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more stabilizers in an amount (wt.%) of 0-2, 0-1.8, 0-1.6, 0-1.4, 0-1.2, 0-1, 0-0.8, 0-0.6, 0-0.4, 0-0.2, 0-0.1, 0-0.05, 0-0.01, >0-2, >0- 1.8, >0-1.6, >0-1.4, >0-1.2, >0-1, >0-0.8, >0-0.6, >0-0.4, >0-0.2, >0-0.1, >0-0.05, >0-0.01, 0.01-2, 0.01-1.8, 0.01-1.6, 0.01-1.4, 0.01-1.2, 0.01-1, 0.01-0.8, 0.01-0.6, 0.01-0.4, 0.01-0.2, 0.01-0.1, 0.01- 0.05, 0.05-2, 0.05-1.8, 0.05-1.6, 0.05-1.4, 0.05-1.2, 0.05-1, 0.05-0.8, 0.05-0.6, 0.05-0.4, 0.05-0.2, 0.05-0.1, 0.1-2, 0.1-1.8, 0.1-1.6, 0.1-1.4, 0.1-1.2, 0.1-1, 0.1-0.8, 0.1-0.6, 0.1-0.4, 0.1-0.2, 0.2-2, 0.2-1.8, 0.2-1.6, 0.2-1.4, 0.2-1.2, 0.2-1, 0.2-0.8, 0.2-0.6, 0.2-0.4, 0.4-2, 0.4-1.8, 0.4-1.6, 0.4-1.4, 0.4-1.2, 0.4-1, 0.4-0.8, 0.4-0.6, 0.6-2, 0.6-1.8, 0.6-1.6, 0.6-1.4, 0.6-1.2, 0.6-1, 0.6-0.8, 0.8-2, 0.8-1.8, 0.8-1.6, 0.8-1.4, 0.8-1.2, 0.8-1, 1-2, 1-1.8, 1-1.6, 1-1.4, 1-1.2, 1.2-2, 1.2-1.8, 1.2-1.6, 1.2-1.4, 1.4-2, 1.4-1.8, 1.4- 1.6, 1.6-2, 1.6-1.8, or 1.8-2, based on total weight of the cosmetic composition. In particular, in some aspects, the cosmetic compositions and / or carriers comprise the one or more stabilizers in an amount of 0.1-1 wt.%, 0.2-0.8 wt.%, 0. 1-0.4 wt.%, 0.5-1 wt.%, or 0.8-1 wt.%, based on total weight of the cosmetic composition. In some aspects, the cosmetic composition and / or carrier is free of, or substantially free of, a stabilizer. The amounts herein may refer to a total amount of all stabilizers present, or to any individual stabilizer, as may be specified for a given context.

[0040] In some aspects, the cosmetic compositions and / or carriers comprise one or more pigments. Pigments are a category of carrier components that add color to cosmetic products. Pigments can be organic or inorganic and are used in a wide range of products, from foundations and blushes, to eyeshadows and lipsticks, to lotions. In some aspects, the pigment comprises iron oxide, mica, titanium dioxide, zinc oxide, ultramarines, chromium oxide greens, ferric ferrocyanide, carmine, or any combination thereof.

[0041] The cosmetic compositions and / or carriers can comprise one or more pigments in any suitable amount, based on the total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more pigments in an amount (wt.%) of 0, >0, at least 0.5, at least 1, at least 5, at least 10, at least 15, at least 20, at least 25, at least 30, at least 35, at least 40, at least 45, 50 or less, 45 or less, 40 or less, 35 or less, 30 or less, 25 or less, 20 or less, 15 or less, 10 or less, 5 or less, 1 or less, 0.5 or less, or any range formed therefrom, based on total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more pigments in an amount (wt.%) of 0-50, 0-45, 0-40, 0-35, 0- 30, 0-25, 0-20, 0-15, 0-10, 0-5, 0-1, 0-0.5, >0-50, >0-45, >0-40, >0-35, >0-30, >0-25, >0-20, >0-15, >0-10, >0-5, >0-1, >0-0.5, 0.5-50, 0.5-45, 0.5-40, 0.5-35, 0.5-30, 0.5-25, 0.5-20, 0.5-15, 0.5-10, 0.5-5, 1-50, 1-45, 1-40, 1-35, 1-30, 1-25, 1-20, 1-15, 1-10, 1-5, 5-50, 5-45, 5-40, 5-35, 5-30, 5-25, 5-20, 5- 15, 5-10, 10-50, 10-45, 10-40, 10-35, 10-30, 10-25, 10-20, 10-15, 15-50, 15-45, 15-40, 15-35, 15-30, 15-25, 15-20, 20-50, 20-45, 20-40, 20-35, 20-30, 20-25, 25-50, 25-45, 25-40, 25-35, 25-30, 30-50, 30- 45, 30-40, 30-35, 35-50, 35-45, 35-40, 40-50, 40-45, or 45-50, based on total weight of the cosmetic composition. In particular, in some aspects, the cosmetic compositions and / or carriers comprise the one or more pigments in an amount of 5-15 wt.%, 1-15 wt.%, or 1-10 wt.%, based on total weight of the cosmetic composition. In some aspects, the cosmetic composition and / or carrier is free of, or substantially free of, an pigment. The amounts herein may refer to a total amount of all pigments present, or to any individual pigment, as may be specified for a given context.

[0042] In some aspects, the cosmetic compositions and / or carriers comprise one or more texturizers. Texturizers are a category of carrier components that contribute to the sensory attributesof a product, such as its feel, look, or application. Texturizers can help to improve a product's spreadability, absorption, or finish on the skin or hair. Texturizers may also act as abrasives, providing an exfoliating quality to the cosmetic composition. Although the bioactive glasses disclosed herein may have an abrasive effect in the cosmetic compositions, the bioactive glasses are not considered an abrasive herein for purposes of the amounts or inclusion of the one or more texturizers. In some aspects, the texturizer comprises silica, boron nitride, kaolin, talc, magnesium hydroxide, polymethylsilsesquioxane, aluminum starch octenylsuccinate, nylon- 12, silica silylate, com starch, rice starch, zinc orthophosphate, sodium bicarbonate, alumina, calcium carbonate, calcium pyrophosphate, or any combination thereof.

[0043] The cosmetic compositions and / or carriers can comprise one or more texturizers in any suitable amount, based on the total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more texturizers in an amount (wt.%) of 0, >0, at least 0.5, at least 1, at least 5, at least 10, at least 15, at least 20, at least 25, at least 30, at least 35, at least 40, at least 45, 50 or less, 45 or less, 40 or less, 35 or less, 30 or less, 25 or less, 20 or less, 15 or less, 10 or less, 5 or less, 1 or less, 0.5 or less, or any range formed therefrom, based on total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise the one or more texturizers in an amount (wt.%) of 0-50, 0-45, 0-40, 0-35, 0- 30, 0-25, 0-20, 0-15, 0-10, 0-5, 0-1, 0-0.5, >0-50, >0-45, >0-40, >0-35, >0-30, >0-25, >0-20, >0-15, >0-10, >0-5, >0-1, >0-0.5, 0.5-50, 0.5-45, 0.5-40, 0.5-35, 0.5-30, 0.5-25, 0.5-20, 0.5-15, 0.5-10, 0.5-5, 1-50, 1-45, 1-40, 1-35, 1-30, 1-25, 1-20, 1-15, 1-10, 1-5, 5-50, 5-45, 5-40, 5-35, 5-30, 5-25, 5-20, 5- 15, 5-10, 10-50, 10-45, 10-40, 10-35, 10-30, 10-25, 10-20, 10-15, 15-50, 15-45, 15-40, 15-35, 15-30, 15-25, 15-20, 20-50, 20-45, 20-40, 20-35, 20-30, 20-25, 25-50, 25-45, 25-40, 25-35, 25-30, 30-50, 30- 45, 30-40, 30-35, 35-50, 35-45, 35-40, 40-50, 40-45, or 45-50, based on total weight of the cosmetic composition. In particular, in some aspects, the cosmetic compositions and / or carriers comprise the one or more texturizers in an amount of 0-5, 1-5, 0.5-10, 5-15 wt.%, 1-15 wt.%, or 1-10 wt.%, based on total weight of the cosmetic composition. In some aspects, the cosmetic composition and / or carrier is free of, or substantially free of, an texturizer. The amounts herein may refer to a total amount of all pigments present, or to any individual texturizer, as may be specified for a given context.

[0044] In some aspects, the cosmetic compositions and / or carriers comprise one or more diluents. Diluents are a category of carrier components that generally serve as the majority component of a cosmetic composition or carrier. Diluents can help to adjust the concentration of other ingredients, influence the texture and spreadability of the product, or deliver ingredients onto the skin. In some aspects, the diluent comprises water, glycerin, seed oil, wax, starch, magnesium stearate, octyldodecanol, pearl powder, caprylic / capric triglyceride, squalane, isopropyl palmitate, cyclomethicone, decyl oleate, C12-C15 alkyl benzoate, or any combination thereof.

[0045] The cosmetic compositions and / or carriers can comprise one or more diluents in any suitable amount, based on the total weight of the cosmetic composition. Generally, the diluent is present in an amount that brings the total amount of the cosmetic composition to 100 wt.%. For example, if formulating a composition with 1 wt.% humectant, 3 wt.% emulsifier, 10 wt.% texturizer, and 5 wt.% pigment, the remainder can be a diluent that brings the total amount to 100 wt.%, and in this case, that amount would be 81 wt.% diluent, based on total weight of the cosmetic composition. In some aspects, cosmetic compositions and / or carriers comprise a diluent in an amount (wt.%) of at least 1, at least 5, at least 10, at least 15, at least 20, at least 25, at least 30, at least 35, at least 40, at least 45, at least 50, at least 55, at least 60, at least 65, at least 70, at least 75, at least 80, at least 85, at least 90, at least 95, 99 or less, 95 or less, 90 or less, 85 or less, 80 or less, 75 or less, 70 or less, 65 or less, 60 or less, 55 or less, 50 or less, 45 or less, 40 or less, 35 or less, 30 or less, 25 or less, 20 or less, 15 or less, 10 or less, 5 or less, 1 or less, or any range formed therefrom, based on total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions and / or carriers comprise a diluent in an amount (wt.%) of 1-99, 1-95, 1-90, 1-85, 1-80, 1-75, 1-70, 1-65, 1-60, 1-55, 1-50, 1-45, 1-40, 1-35, 1-30, 1-25, 1-20, 1-15, 1-10, 1-5, 5-99, 5-95, 5-90, 5-85, 5-80, 5-70, 5-60, 5- 50, 5-45, 5-40, 5-30, 5-25, 5-15, 5-10, 10-99, 10-95, 10-85, 10-80, 10-75, 10-70, 10-65, 10-60, 10-55, 10-50, 10-45, 10-40, 10-35, 10-30, 10-25, 10-20, 10-15, 15-99, 15-90, 15-80, 15-75, 15-70, 15-65, 15- 60, 15-55, 15-50, 15-45, 15-40, 15-35, 15-30, 15-25, 15-20, 20-99, 20-95, 20-85, 20-80, 20-75, 20-70, 20-65, 20-60, 20-55, 20-50, 20-45, 20-40, 20-35, 20-30, 20-25, 25-99, 25-95, 25-90, 25-80, 25-75, 25- 70, 25-65, 25-60, 25-55, 25-50, 25-45, 25-40, 25-35, 25-30, 30-95, 30-80, 30-75, 30-70, 30-65, 30-60, 30-55, 30-50, 30-45, 30-40, 30-35, 35-99, 35-80, 35-75, 35-70, 35-65, 35-60, 35-55, 35-50, 35-45, 35- 40, 40-95, 40-85, 40-80, 40-75, 40-70, 40-65, 40-60, 40-55, 40-50, 40-45, 45-99, 45-90, 45-80, 45-75, 45-70, 45-65, 45-60, 45-55, 45-50, 50-90, 50-80, 50-75, 50-70, 50-65, 50-60, 50-55, 55-80, 55-75, 55- 70, 55-65, 55-60, 60-95, 60-80, 60-75, 60-70, 60-65, 65-95, 65-80, 65-75, 65-70, 70-99, 70-95, 70-85, 70-80, 70-75, 75-99, 75-95, 75-80, 80-99, 80-95, 80-90, 85-99, 85-95, 85-90, 90-99, 90-95, or 95-99, based on total weight of the cosmetic composition. In some aspects, the diluent can be considered a solvent, which can be aqueous or non-aqueous. Generally, when aqueous, the solvent is or comprises water, and when non-aqueous, the solvent is or comprises glycerin. In some aspects, a combination of water and glycerin is employed, and the weight percent of glycerin in such a mixture can be 1-99, 5- 95, 10-90, 15-85, 20-80, 25-75, 30-70, 35-65, 40-60, 45-55, 1-50, 5-45, 10-40, 15-35, 50-95, 55-90, 60-85, or 65-80, based on total weight of glycerin and water.

[0046] In some aspects, the cosmetic compositions and / or carriers comprise one or more pH modifiers and / or buffers. In some aspects, the one or more pH modifiers and / or buffers include acids or bases. In some aspects, the acids include organic or inorganic bases, including sulfuric acid, hydrochloric acid, citric acid, oxalic acid, acetic acid, and so forth, or any combination thereof. In some aspects, the bases include organic or inorganic bases, including hydroxides (e.g., sodiumhydroxide, potassium hydroxide, lithium hydroxide, ammonium hydroxide, etc.), amine bases (triethyl amine, pyridine, etc.), and so forth, or any combination thereof. In some aspects, buffers include organic or inorganic buffers, including citric acid, acetic acid, KH2PO4, Na2HPC>4, CHES (N- cyclohexyl-2-aminoethanesulfonic acid), borate, and the like, or any combination thereof. In some aspects, the cosmetic compositions and / or carriers comprise one or more pH modifiers and / or buffers in an amount of 0 wt.% or greater than 0 wt.%. In some aspects, the cosmetic compositions and / or carriers comprise one or more pH modifiers and / or buffers in an amount of 15 wt.% or less. In some aspects, the cosmetic compositions comprise one or more pH modifiers and / or buffers in an amount (wt.%) of 0-25, 0-24, 0-22, 0-20, 0-18, 0-16, 0-14, 0-12, 0-10, 0-8, 0-6, 0-4, 0-2, 0-1, 0-0.5, 0-0.1, >0- 25, >0-24, >0-22, >0-20, >0-18, >0-16, >0-14, >0-12, >0-10, >0-8, >0-6, >0-4, >0-2, >0-1, >0-0.5, >0-0.1, 0.0001-25, 0.0001-5, 0.0001-1, 0.1-25, 0.1-24, 0.1-22, 0.1-20, 0.1-18, 0.1-16, 0.1-14, 0.1-12, 0.1-10, 0.1-8, 0.1-6, 0.1-4, 0.1-2, 0.1-1, 0.1-0.5, 0.5-25, 0.5-24, 0.5-22, 0.5-20, 0.5-18, 0.5-16, 0.5-14, 0.5-12, 0.5-10, 0.5-8, 0.5-6, 0.5-4, 0.5-2, 0.5-1, 1-25, 1-24, 1-22, 1-20, 1-18, 1-16, 1-14, 1-12, 1-10, 1- 8, 1-6, 1-4, 1-2, 2-25, 2-24, 2-22, 2-20, 2-18, 2-6, 2-14, 2-12, 2-10, 2-8, 2-6, 2-4, 4-25, 4-24, 4-22, 4- 20, 4-18, 4-16, 4-14, 4-12, 4-10, 4-8, 4-6, 6-25, 6-24, 6-22, 6-20, 6-18, 6-16, 6-14, 6-12, 6-10, 6-8, 8- 25, 8-24, 8-22, 8-20, 8-18, 8-16, 8-14, 8-12, 8-10, 10-25, 10-24, 10-22, 10-20, 10-18, 10-16, 10-14, 10-12, 12-25, 12-24, 12-22, 12-20, 12-18, 12-16, 12-14, 14-25, 14-24, 14-22, 14-20, 14-18, 14-16, 16- 25, 16-24, 16-22, 16-20, 16-18, 18-25, 18-24, 18-22, 18-20, 20-25, 20-24, 20-22, 22-25, 22-24, or 24- 25, based on total weight of the cosmetic composition. In some aspects, the cosmetic compositions and / or carriers are free, or substantially free, of a pH modifier and / or buffer. The amounts disclosed herein for “pH modifiers and / or buffers” are for the sum total of all pH modifiers and buffers present in the cosmetic composition.

[0047] In some aspects, the cosmetic compositions and / or carriers have a pH of 6-10, 6-9.5, 6-9, 6-8.5, 6-8, 6-7.5, 6-7, 6-6.5, 6.5-10, 6.5-9.5, 6.5-9, 6.5-8.5, 6.5-8, 6.5-7.5, 6.5-7, 7-10, 7-9.5, 7-9, 7-8.5, 7-8, 7-7.5, 7.5-10, 7.5-9.5, 7.5-9, 7.5-8.5, 7.5-8, 8-10, 8-9.5, 8-9, 8-8.5, 8.5-10, 8.5-9.5, 8.5-9, 9-10, 9-9.5, or 9.5-10. In some aspects, the cosmetic compositions and / or carriers contain a pH modifier and / or buffer in an amount sufficient to achieve such pH values.

[0048] In some aspects, the cosmetic product comprises a vessel. In some aspects, the vessel is configured to contain a cosmetic composition. In some aspects, the vessel contains the cosmetic composition. Vessels come in a wide variety of configurations, particularly when designed to contain a cosmetic product, and such vessels can take any suitable form. For example, in some aspects, the vessel comprises a bottle, ajar, a tube, a bag, a canister, a pouch, a cartridge, a flask, a vial, a cask, a drum, a barrel, a box, a crate, a keg, a bin, a jug, a pot, a sack, a basket, a bucket, a carton, a package, a tin, or any combination thereof. In some aspects, the vessel comprises a bottle, ajar, or a tube.

[0049] In some aspects, the cosmetic product comprises a closing component. In some aspects, the closing component is configured to at least partially close the vessel. As used herein, “close” used inreference to a closing component means to block or obstruct an opening, gap, or passage, either completely or to at least some degree, in order to prevent or restrict the passage of substances (such as a cosmetic composition) through it under normal storage and / or use conditions, unless or until such time that the passage of the substance is desired, for example, by a user of the cosmetic product (or even a distributor or retailer that repackages bulk cosmetic composition from a large cosmetic product vessel to a smaller cosmetic product vessel). In this regard, the closing component can be a lid (e.g., screw top lid) that closes ajar containing a cosmetic composition, and the lid can be removed to provide access to the cosmetic composition during use and / or application of the cosmetic composition. In some aspects, the closing component, can also be a pump, which can be pressed by a user so as to deliver the cosmetic composition through the pump to the user. In some aspects, the closing component comprises a cap, a lid, a stopper, a cork, a seal, a plug, a cover, a clamp, a zipper, a snap, a lock, a slider, a drawstring, a screw, a buckle, a button, a hook, a clasp, a bung, a spigot, a valve, a lid with a gasket, a flip-top, a twist-off cap, a press-on lid, a roll-on applicator, a pump, a dropper, a sprayer, a dispenser, a heat seal, a pressure seal, a tie, a twist tie, a clip, a band, a cinch, a knot, a self-sealing mechanism, an adhesive strip, a zip lock, a staple, a fold and tuck closure, or any combination thereof.

[0050] Bioactive glasses are a group of glass and / or glass ceramic materials that have shown biocompatibility or bioactivity, which has allowed them to be incorporated into human or animal physiology. In some aspects, disclosed is a bioactive glass comprising SiC>2, CaO, and P2O5. In some aspects, the bioactive glass further comprises ZrO? and / or F". In some aspects, when the bioactive glass is subjected to a composition at 37 °C and a pH of 6.5 to form a mixture, a total amount of calcium ions in the mixture increases every 2 hours over a 4 hour period (e.g., or over a 6 hour period, 8 hour period 10 hour period, 12 hour period, 14 hour period, 16 hour period, 18 hour period, 20 hour period, 22 hour period, and / or 24 hour period), in which the composition comprises 0.05 wt.% sodium chloride (e.g., in some aspects 0.01-0.1 wt.%), 0.1 wt.% urea (e.g., in some aspects 0.05-0.15 wt.%), 0.1 wt.% lactic acid (e.g., in some aspects 0.05-0.15 wt.%), and a balance of water. In some aspects, this composition represents artificial sweat and is meant to represent what is in the environment that the bioactive glass encounters when present on skin. The composition’s pH can be adjusted with acid, base, and / or buffer to achieve the desired pH. In some aspects, the bioactive glass forms a bioactive crystalline phase when subjected to the artificial sweat.

[0051] In some aspects, a bioactive glass forms a bioactive crystalline phase when subjected to the simulated body fluid of Table 1A or IB at 37 °C. In some aspects, the formation of the bioactive crystalline phase takes place within 10 days, within 9 days, within 8 days, within 7 days, within 6 days, within 5 days, within 4 days, within 3 days, within 2 days, or within 1 day of subjecting at 37 °C to the simulated body fluid of Table 1A or IB or other aqueous compositions. In some aspects, theformation of the bioactive crystalline phase takes place within 7 days at 37 °C. In some aspects, the formation of the bioactive crystalline phase takes place within 1 day at 37 °C.

[0052] In some aspects, the simulated body fluid comprises phosphate, calcium, fluoride, sodium, potassium, magnesium, a buffer, or any combination thereof. In some aspects, the aqueous composition and / or artificial saliva comprises potassium chloride, ammonium chloride, potassium dihydrogen phosphate, magnesium chloride hexahydrate, calcium chloride, HEPES buffer, sodium azide, sodium hydroxide, a combination thereof, or any combination thereof. In some aspects, the simulated body fluid may include a salt solution comprising NaCl, NaHCOs, KC1, K2HPO4, MgCh- 6H2O, CaCE. NaSCE, (HOCtEECNIE in nano-pure water, with pH adjusted with acid, such as HC1. In some examples, the simulated body fluid comprises the components set forth below in Table 1A and IB. In some aspects, such compositions in Tables 1A-1B are artificial saliva compositions.Table 1ATable IB

[0053] Without wishing to be bound by theory, it is believed that one or more components of the simulated body fluid, which has chemical composition similarities to real sweat or saliva, facilitates formation of a bioactive crystalline phase and / or facilitates release of various ions from the bioactive glass as described elsewhere herein, such as silicon, silicate, phosphate, calcium, magnesium, or any combination thereof. For example, in some aspects, it is believed that one or more of phosphate, calcium, fluoride, sodium, potassium, magnesium, a buffer, or any combination thereof, but particularly the phosphate, calcium, fluoride, or a combination thereof, facilitates formation of a bioactive crystalline phase and / or release of ions. In this regard, in some aspects, the bioactive glass acts an ion source, and such ions are believed to play a beneficial role in skin care, hair care, fur care, and so forth, as described elsewhere herein.

[0054] In some aspects, a bioactive crystalline phase is formed when subjected to the simulated body fluid of Table 1A or Table IB. In some aspects, the glass compositions herein form a bioactive crystalline phase when subjected to a simulated body fluid comprising one or more of potassium chloride, ammonium chloride, potassium dihydrogen phosphate, magnesium chloride hexahydrate, calcium chloride, HEPES buffer, sodium azide, sodium hydroxide, NaCl, NaHCOs, NaSCE, (HOCFEjsCNFE in nano-pure water, or any combination thereof. For example, the simulated body fluid may comprise phosphate, calcium, fluoride, sodium, potassium, magnesium, a buffer, or any combination thereof.

[0055] In some aspects, the bioactive glass comprises a combination of SiCE, CaO, and P2O5. In some aspects, the bioactive glass further comprises ZrCE In some aspects, the bioactive glass further comprises F . In some aspects, the bioactive glass further also comprises MgO. In some aspects, the bioactive glass further comprises Li2O, Na2O, K2O, or any combination thereof. In some aspects, the amount of Li2O+Na2O+K2O is less than or equal to 5 wt.%.

[0056] In some aspects, the bioactive glass comprises SiCE, CaO, and P2O5. In some aspects, the bioactive glass comprises SiO2, CaO, P2O5, ZrO2, and F". In some aspects, when subjected to an aqueous composition, such as artificial sweat or artificial saliva, such a bioactive glass forms a bioactive crystalline phase (e.g., within 7 days). In some aspects, when subjected to an aqueous composition, such as artificial sweat, such a bioactive glass releases calcium ions into the aqueous composition.

[0057] In some aspects, the bioactive glass comprises SiCE in an amount of 20-55 wt.%. In some aspects, the bioactive glass comprises SiCE in an amount of 15-55 wt.%. In some aspects, thebioactive glass comprises CaO in an amount of 20-55 wt.%. In some aspects, the bioactive glass comprises CaO in an amount of 20-60 wt.%. In some aspects, the bioactive glass comprises P2O5 in an amount of 5-30 wt.%. In some aspects, the bioactive glass comprises ZrO2 in an amount of >0-15 wt.% (e.g., 0.1-15 wt.%). In some aspects, the bioactive glass comprises F in an amount of 0-5 wt.% (e.g., >0-5 wt.%).

[0058] In some aspects, the bioactive glass comprises:15-55 wt.% SiO2,0.1-15 wt.% ZrO2;20-60 wt.% CaO, and5-30 wt.% P2O5, based on total weight of bioactive glass.

[0059] In some aspects, when the bioactive glass (e.g., in the form of a cosmetic composition) is subjected to artificial sweat (or real sweat), calcium ions are released from the bioactive glass.

[0060] In some aspects, the bioactive glass comprises:15-55 wt.% SiO2,0.1-15 wt.% ZrO2,20-60 wt.% CaO,5-30 wt.% P2O5,0-25 wt.% MgO,0-10 wt.% SrO,0-10 wt.% ZnO,0-5 wt.% AI2O3,0-5 wt.% B2O3,0-5 wt.% Na2O,0-5 wt.% K2O,0-2 wt.% CeO2,0-5 wt.% F",0-5 wt.% Na2O+K2O+Li2O, or any combination thereof, based on total weight of bioactive glass.

[0061] In some aspects, the bioactive glass comprises:25-55 wt.% SiO2,0.1-15 wt.% ZrO2;20-55 wt.% CaO,5-30 wt.% P2O5,0-10 wt.% MgO,0-10 wt.% SrO,0-10 wt.% ZnO,0-5 wt.% AI2O3,0-5 wt.% B2O3,0-5 wt.% Na2O,0-5 wt.% K2O,0-2 wt.% CeC>2,0-5 wt.% F",0-5 wt.% Na2O+K.2O+Li2O, or or any combination thereof, based on total weight of bioactive glass.

[0062] In some aspects, the bioactive glasses comprise: 25-35 wt.% SiO2, 0.1-15 wt.% ZrCh;35-50 wt.% CaO, 15-25 wt.% P2O5, 0-25 wt.% MgO, 0-10 wt.% SrO, 0-10 wt.% ZnO, 0-5 wt.% AI2O3, 0-5 wt.% B2O3, 0-5 wt.% F", 0-5 wt.% Na2O, 0-5 wt.% K2O, 0-2 wt.% CeO2, 0-5 wt.% Na2O+K2O+Li2O, or or any combination thereof, based on total weight of bioactive glass.

[0063] In some aspects, the bioactive glasses comprise: 15-45 wt.% SiO2;0.1-15 wt.% ZrO2;30-60 wt.% CaO; and8-30 P2O5; based on total weight of bioactive glass.

[0064] In some aspects, the bioactive glasses comprise: 15-45 wt.% SiO2;0.1-15 wt.% ZrO2;30-60 wt.% CaO;8-30 P2O5;0-25 wt.% MgO;0-10 wt.% SrO;0-10 wt.% ZnO;0-5 wt.% AI2O3;0-5 wt.% B2O3;0-5 wt.% F";0-5 wt.% Na2O;0-5 wt.% K2O;0-5 wt.% Na2O+K2O+Li2O; or or any combination thereof; based on total weight of bioactive glass.

[0065] The bioactivity is influenced by the composition of the glass. In some aspects, the bioactive glass acts as a regenerative agent by releasing ions that are beneficial to the skin or hair of a human or animal, such as by providing reparative, regenerative, anti-inflammatory, anti-aging, and / or antioxidant effects.

[0066] Silicon dioxide (SiO2) may serve as the primary glass-forming oxide component of the bioactive glasses disclosed herein. SiO2may be included to provide high temperature stability and chemical durability. However, if too much SiO2is included, such as a glass containing pure SiO2, the melting temperature is too high to be readily workable (e.g., greater than 200 poise temperature). Silicon / silicate ions may also have a role in combating dermal aging, such as through providing reparative, regenerative, anti-inflammatory, anti-aging, and / or antioxidant effect. In addition, bioactive glasses including too much SiO2may suffer from decreased bioactivity.

[0067] In some aspects, the bioactive glasses comprise SiO2in an amount of at least 15 wt.% or at least 25 wt.%. In some aspects, the bioactive glasses comprise SiO2in an amount of 55 wt.% or less or 45 wt.% or less. In some aspects, the bioactive glasses comprise SiO2in an amount (wt.%) of 15- 55, 15-50, 15-45, 15-40, 15-35, 15-30, 15-25, 15-20, 20-55, 20-50, 20-45, 20-40, 20-35, 20-30, 20-25, 25-55, 25-50, 25-45, 25-40, 25-35, 25-30, 30-55, 30-50, 30-45, 30-40, 30-35, 35-55, 35-50, 35-45, 35- 40, 40-55,40-50, 40-45, 45-55, 45-50, or 50-55. In some aspects, the bioactive glass is substantially free of, or does not contain, SiO2.

[0068] Phosphorus pentoxide (P2O5) may serve as a network former in bioactive glasses. Furthermore, the liberation of phosphate ions to the surface of bioactive glasses contributes to the formation of apatite. Apatite is an inorganic mineral in bone and teeth, and formation of apatite in a simulated body fluid is one criterion for a material to be bioactive, according to ASTM F1538-03(2017), hereby incorporated by reference in its entirety for all purposes. The inclusion of phosphate ions in the bioactive glass increases apatite formation rate and the binding capacity of the hard tissues (e.g., bone, tooth, etc.). Phosphate ions may have a role in combating dermal aging, such as through providing reparative, regenerative, anti-inflammatory, anti-aging, and / or antioxidant effect. In addition, P2O5 can increase the viscosity of the glass, which in turn expands the range of operating temperatures, and is therefore an advantage to the manufacture and formation of the glass.

[0069] In some aspects, the bioactive glasses comprise P2O5 in an amount of at least 5 wt.%. In some aspects, the bioactive glasses comprise P2O5 in an amount of 30 wt.% or less. In some aspects, the bioactive glasses comprise P2O5 in an amount (wt.%) of 5-30, 5-25, 5-20, 5-15, 5-10, 5-8, 8-30, 8- 25, 8-20, 8-15, 8-10, 10-30, 10-25, 10-20, 10-15, 15-30, 15-25, 15-20, 20-30, 20-25, or 25-30.

[0070] Zirconium dioxide (ZrO?) may also be present and serves to function as a network former or intermediate in precursor glasses, as well as a key oxide for improving glass thermal stability by significantly reducing glass devitrification during forming and lowering liquidus temperature. In aspects, ZrC>2 may play a similar role as alumina (AI2O3) in the composition.

[0071] In some aspects, the bioactive glasses comprise ZrCf in an amount of 0 wt.% or greater than 0 wt.%. In some aspects, the bioactive glasses comprise ZrCf in an amount of 15 wt.% or less. In some aspects, the bioactive glasses comprise ZrCf in an amount (wt.%) of 0-15, 0-14, 0-13, 0-12, 0- 11, 0-10, 0-9, 0-8, 0-7, 0-6, 0-5, 0-4, 0-3, 0-2, 0-0.8, 0-0.6, 0-0.4, 0-0.2, 0-0.1, >0-15, >0-14, >0-13, >0-12, >0-11, >0-10, >0-9, >0-8, >0-7, >0-6, >0-5, >0-4, >0-3, >0-2, >0-1, >0-0.8, >0-0.6, >0-0.4, >0-0.2, >0-0.1, 0.1-15, 0.1-14, 0.1-13, 0.1-12, 0.1-11, 0.1-10, 0.1-9, 0.1-8, 0.1-7, 0.1-6, 0.1-5, 0.1-4, 0.1-3, 0.1-2, 0.1-1, 0.1-0.8, 0.1-0.6, 0.1-0.4, 0.1-0.2, 0.2-15, 0.2-14, 0.2-13, 0.2-12, 0.2-11, 0.2-10, 0.2-9, 0.2-8, 0.2-7, 0.2-6, 0.2-5, 0.2-4, 0.2-3, 0.2-2, 0.2-1, 0.2-0.8, 0.2-0.6, 0.2-0.4, 0.4-15, 0.4-14, 0.4- 13, 0.4-12, 0.4-11, 0.4-10, 0.4-9, 0.4-8, 0.4-7, 0.4-6, 0.4-5, 0.4-4, 0.4-3, 0.4-2, 0.4-1, 0.4-0.8, 0.4-0.6, 0.6-15, 0.6-14, 0.6-13, 0.6-12, 0.6-11, 0.6-10, 0.6-9, 0.6-8, 0.6-7, 0.6-6, 0.6-5, 0.6-4, 0.6-3, 0.6-2, 0.6- 1, 0.6-0.8, 0.8-15, 0.8-14, 0.8-13, 0.8-12, 0.8-11, 0.8-10, 0.8-9, 0.8-8, 0.8-7, 0.8-6, 0.8-5, 0.8-4, 0.8-3, 0.8-2, 0.8-1, 1-15, 1-14, 1-13, 1-12, 1-11, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, 2-15, 2-14, 2-13,2-12, 2-11, 2-10, 2-9, 2-8, 2-7, 2-6, 2-5, 2-4, 2-3, 3-15, 3-14, 3-13, 3-12, 3-11, 3-10, 3-9, 3-8, 3-7, 3-6,3-5, 3-4, 4-15, 4-14, 4-13, 4-12, 4-11, 4-10, 4-9, 4-8, 4-7, 4-6, 4-5, 5-15, 5-14, 5-13, 5-12, 5-11, 5-10, 5-9, 5-8, 5-7, 5-6, 6-15, 6-4, 6-13, 6-12, 6-11, 6-10, 6-9, 6-8, 6-7, 7-15, 7-14, 7-13, 7-12, 7-11, 7-10, 7-9, 7-8, 8-15, 8-14, 8-13, 8-12, 8-11, 8-10, 8-9, 9-15, 9-14, 9-13, 9-12, 9-11, 9-10, 10-15, 10-14, 10- 13, 10-12, 10-11, 11-15, 11-4, 11-13, 11-12, 12-15, 12-4, 12-13, 13-15, 13-14, or 14-15. In some aspects, the bioactive glass is substantially free of, or does not contain, ZrC>2.

[0072] In some aspects, the bioactive glasses comprise fluoride (F ), which can form bioactive crystalline phases, such as hydroxyapatite, fluorapatite, carbonated apatite, brushite, or any combination thereof in certain aqueous environments such as in a simulated body fluid (or real body fluid, such as saliva or sweat). In some aspects, at least some of such bioactive crystalline phases areresistant to acid corrosion, such as fluorapatite. F can combine with CaO and P2O5 to form fluorapatite to improve the bioactivity of the bioactive glasses. In some aspects, formation of apatite ensures the high bioactivity of the compositions disclosed herein.

[0073] In some aspects, the F in the bioactive glasses is derived from calcium fluoride, magnesium fluoride, sodium fluoride, potassium fluoride, stannous fluoride, sodium monofluorophosphate, sodium difluorophosphate, or any combination thereof.

[0074] In some aspects, the bioactive glasses comprise F in an amount of 0 wt.% or greater than 0 wt.%. In some aspects, the bioactive glasses comprise F in an amount of 5 wt.% or less. In some aspects, the bioactive glasses comprise F in an amount (wt.%) of 0-5, 0-4.5, 0-4, 0-3.5, 0-3, 0-2.5, 0-2, 0-1.5, 0-1, 0-0.5, 0-0.1, >0-5, >0-4.5, >0-4, >0-3.5, >0-3, >0-2.5, >0-2, >0-1.5, >0-1, >0-0.5, >0- 0.4, >0-0.3, >0-0.2, >0-0.1, >0-0.01, 0.01-5, 0.01-4.5, 0.01-4, 0.01-3.5, 0.01-3, 0.01-2.5, 0.01-2, 0.01-1.5, 0.01-1, 0.01-0.5, 0.01-0.4, 0.01-0.3, 0.01-0.2, 0.01-0.1, 0.1-5, 0.1-4.5, 0.1-4, 0.1-3.5, 0.1-3, 0.1-2.5, 0.1-2, 0.1-1.5, 0.1-1, 0.1-0.5, 0.1-0.4, 0.1-0.3, 0.1-0.2, 0.1-0.15, 0.2-5, 0.2-4.5, 0.2-4, 0.2-3.5, 0.2-3, 0.2-2.5, 0.2-2, 0.2-1.5, 0.2-1, 0.2-0.5, 0.2-0.4, 0.2-0.3, 0.3-5, 0.3-4.5, 0.3-4, 0.3-3.5, 0.3-3, 0.3-2.5, 0.3-2, 0.3-1.5, 0.3-1, 0.3-1.5, 0.3-0.4, 0.4-5, 0.4-4.5, 0.4-4, 0.4-3.5, 0.4-3, 0.4-2.5, 0.4-2, 0.4-1.5, 0.4- 1, 0.4-0.5, 0.5-5, 0.5-4.5, 0.5-4, 0.5-3.5, 0.5-3, 0.5-2.5, 0.5-2, 0.5-1.5, 0.5-1, 1-5, 1-4.5, 1-4, 1-3.5, 1-3, 1-2.5, 1-2, 1-1.5, 1.5-5, 1.5-4.5, 1.5-4, 1.5-3.5, 1.5-3, 1.5-2.5, 1.5-2, 2-5, 2-4.5, 2-4, 2-3.5, 2-3, 2-2.5, 2.5-5, 2.5-4.5, 2.5-4, 2.5-3.5, 2.5-3, 3-5, 3-4.5, 3-4, 3-3.5, 3.5-5, 3.5-4.5, 3.5-4, 4-5, 4-4.5, or 4.5-5. In some aspects, the bioactive glass is substantially free of, or does not contain, F".

[0075] Divalent cation oxides (such as alkaline earth oxides and ZnO) improve the melting behavior, chemical durability, and bioactivity of the glass. In addition, alkaline earth oxides may improve other desirable properties in the materials, including influencing the Young’s modulus and the coefficient of thermal expansion. In examples, the bioactive glasses comprise from 30-70 wt.% MO, wherein MO is the sum of MgO, CaO, SrO, BeO, and BaO. In some aspects, the bioactive glasses comprise MO in an amount (wt.%) of 30-70, 30-65, 30-60, 30-55, 30-50, 30-45, 30-40, 30-35, 35-70, 35-65, 35-60, 35-55, 35-50, 35-45, 35-40, 40-70, 40-65, 40-60, 40-55, 40-50, 40-45, 45-70, 45- 65, 45-60, 45-55, 45-50, 50-70, 50-65, 50-60, 50-55, 55-70, 55-65, 55-60, 60-70, 60-65, or 65-70.

[0076] In some aspects, the bioactive glasses comprise CaO. Calcium ions may also have a role in combating dermal aging, such as through providing reparative, regenerative, anti-inflammatory, antiaging, and / or antioxidant effect. In some aspects, the bioactive glasses comprise CaO in an amount of at least 20 wt.%. In some aspects, the bioactive glasses comprise CaO in an amount of 60 wt.% or less or 55 wt.% or less. In some aspects, the bioactive glasses comprise CaO in an amount (wt.%) of 20- 60, 20-55, 20-50, 20-45, 20-40, 20-35, 20-30, 20-25, 25-60, 25-55, 25-50, 25-45, 25-40, 25-35, 25-30, 30-60, 30-55, 30-50, 30-45, 30-40, 30-35, 35-60, 35-55, 35-50, 35-45, 35-40, 40-60, 40-55, 40-50, 40- 45, 45-60, 45-55, 45-50, 50-60, 50-55, or 55-60. In some aspects, the bioactive glass is substantially free of, or does not contain, CaO.

[0077] In some aspects, the bioactive glasses comprise MgO. In some aspects, the inclusion of MgO can improve liquidus of the precursor glass to avoid devitrification during forming. Magnesium ions may also have a role in combating dermal aging, such as through providing reparative, regenerative, anti-inflammatory, anti-aging, and / or antioxidant effect. In some aspects, the bioactive glasses comprise MgO in an amount of 0 wt.% or greater than 0 wt.%. In some aspects, the bioactive glasses comprise MgO in an amount of 25 wt.% or less or 10 wt.% or less. In some aspects, the bioactive glasses comprise MgO in an amount (wt.%) of 0-10, 0-9, 0-8, 0-7, 0-6, 0-5, 0-4, 0-3, 0-2, 0- 1, 0-0.5, 0-0.1, >0-10, >0-9, >0-8, >0-7, >0-6, >0-5, >0-4, >0-3, >0-2, >0-1, >0-0.5, >0-0.1, 0.1-10, 0.1-9, 0.1-8, 0.1-7, 0.1-6, 0.1-5, 0.1-4, 0.1-3, 0.1-2, 0.1-1, 0.1-0.5, 0.5-10, 0.5-9, 0.5-8, 0.5-7, 0.5-6, 0.5-5, 0.5-4, 0.5-3, 0.5-2, 0.5-1, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, 2-10, 2-9, 2-8, 2-7, 2-6, 2- 5, 2-4, 2-3, 3-10, 3-9, 3-8, 3-7, 3-6, 3-5, 3-4, 4-10, 4-9, 4-8, 4-7, 4-6, 4-5, 5-10, 5-9, 5-8, 5-7, 5-6, 6- 10, 6-9, 6-8, 6-7, 7-10, 7-9, 7-8, 8-10, 8-9, or 9-10. In some aspects, the bioactive glasses comprise MgO in an amount (wt.%) of 0-25, 0-20, 0-15, 0-10, 0-5, 0-1, >0-25, >0-20, >0-15, >0-10, >0-5, >0- 1, 1-25, 1-20, 1-15, 1-10, 1-5, 5-25, 5-20, 5-15, 5-10, 10-25, 10-20, 10-15, 15-25, 15-20, or 20-25. In some aspects, the bioactive glass is substantially free of, or does not contain, MgO.

[0078] In some aspects, the bioactive glasses comprise SrO. In some aspects, the inclusion of SrO can improve liquidus of the precursor glass to avoid devitrification during forming. Moreover, in some aspects, SrO may also enter the structure of apatite to improve bioactivity. In some aspects, the bioactive glasses comprise SrO in an amount of 0 wt.% or greater than 0 wt.%. In some aspects, the bioactive glasses comprise SrO in an amount of 10 wt.% or less. In some aspects, the bioactive glasses comprise SrO in an amount (wt.%) of 0-10, 0-9, 0-8, 0-7, 0-6, 0-5, 0-4, 0-3, 0-2, 0-1, 0-0.5, 0- 0.1, >0-10, >0-9, >0-8, >0-7, >0-6, >0-5, >0-4, >0-3, >0-2, >0-1, >0-0.5, >0-0.1, 0.1-10, 0.1-9, 0.1-8, 0.1-7, 0.1-6, 0.1-5, 0.1-4, 0.1-3, 0.1-2, 0.1-1, 0.1-0.5, 0.5-10, 0.5-9, 0.5-8, 0.5-7, 0.5-6, 0.5-5, 0.5-4, 0.5-3, 0.5-2, 0.5-1, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, 2-10, 2-9, 2-8, 2-7, 2-6, 2-5, 2-4, 2-3, 3- 10, 3-9, 3-8, 3-7, 3-6, 3-5, 3-4, 4-10, 4-9, 4-8, 4-7, 4-6, 4-5, 5-10, 5-9, 5-8, 5-7, 5-6, 6-10, 6-9, 6-8, 6- 7, 7-10, 7-9, 7-8, 8-10, 8-9, or 9-10. In some aspects, the bioactive glass is substantially free of, or does not contain, SrO.

[0079] In some aspects, the bioactive glasses comprise ZnO. In some aspects, the inclusion of ZnO can improve liquidus of the precursor glass to avoid devitrification during forming. Moreover, in some aspects, ZnO may also enter the structure of apatite to improve bioactivity. In some aspects, the bioactive glasses comprise ZnO in an amount of 0 wt.% or greater than 0 wt.%. In some aspects, the bioactive glasses comprise ZnO in an amount of 10 wt.% or less. In some aspects, the bioactive glasses comprise ZnO in an amount (wt.%) of 0-10, 0-9, 0-8, 0-7, 0-6, 0-5, 0-4, 0-3, 0-2, 0-1, 0-0.5, 0- 0.1, >0-10, >0-9, >0-8, >0-7, >0-6, >0-5, >0-4, >0-3, >0-2, >0-1, >0-0.5, >0-0.1, 0.1-10, 0.1-9, 0.1-8, 0.1-7, 0.1-6, 0.1-5, 0.1-4, 0.1-3, 0.1-2, 0.1-1, 0.1-0.5, 0.5-10, 0.5-9, 0.5-8, 0.5-7, 0.5-6, 0.5-5, 0.5-4, 0.5-3, 0.5-2, 0.5-1, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, 2-10, 2-9, 2-8, 2-7, 2-6, 2-5, 2-4, 2-3, 3-10, 3-9, 3-8, 3-7, 3-6, 3-5, 3-4, 4-10, 4-9, 4-8, 4-7, 4-6, 4-5, 5-10, 5-9, 5-8, 5-7, 5-6, 6-10, 6-9, 6-8, 6- 7, 7-10, 7-9, 7-8, 8-10, 8-9, or 9-10. In some aspects, the bioactive glass is substantially free of, or does not contain, ZnO.

[0080] In some aspects, CaO is found to be able to react with P2O5 to form apatite when immersed in a simulated body fluid (SBF), such as artificial saliva or artificial sweat, or in vivo or in real saliva or sweat. The release of Ca2+ions from the surface of the glass contributes to the formation of a layer rich in calcium phosphate. Thus, the combination of P2O5 and CaO may provide advantageous compositions for bioactive glasses.

[0081] In some aspects, the bioactive glasses comprise the sum P2Os+CaO in an amount of 40 wt.% or more. In some aspects, the bioactive glasses comprise the sum P2Os+CaO in an amount of 70 wt.% or less. In some aspects, the bioactive glasses comprise the sum P2Os+CaO in an amount (wt.%) of 40-70, 40-65, 40-60, 40-55, 40-50, 40-45, 45-70, 45-65, 45-60, 45-55, 45-50, 50-70, 50-65, 50-60, 50-55, 55-70, 55-65, 55-60, 60-70, 60-65, or 65-70.

[0082] In some aspects, the bioactive glasses comprise the sum MgO+CaO in an amount of at least 20 wt.%. In some aspects, the bioactive glasses comprise the sum MgO+CaO in an amount of 70 wt.% or less. In some aspects, the bioactive glasses comprise the sum MgO+CaO in an amount (wt.%) of 20-70, 20-65, 20-60, 20-55, 20-50, 20-45, 20-40, 20-35, 20-30, 20-25, 25-70, 25-65, 25-60, 25-55, 25-50, 25-45, 25-40, 25-35, 25-30, 30-70, 30-65, 30-60, 30-55, 30-50, 30-45, 30-40, 30-35, 35-70, 35- 65, 35-60, 35-55, 35-50, 35-45, 35-40, 40-70, 40-65, 40-60, 40-55, 40-50, 40-45, 45-70, 45-65, 45-60, 45-55, 45-50, 50-70, 50-65, 50-60, 50-55, 55-70, 55-65, 55-60, 60-70, 60-65, or 65-70.

[0083] In some aspects, the bioactive glasses comprise the sum F +P2O5 in an amount of at least 5 wt.%. In some aspects, the bioactive glasses comprise the sum F +P2O5 in an amount of 35 wt.% or less. In some aspects, the bioactive glasses comprise the sum F +P2O5 in an amount (wt.%) of 5-35, 5- 30, 5-25, 5-20, 5-15, 5-10, 10-35, 10-30, 10-25, 10-20, 10-15, 15-35, 15-30, 15-25, 15-20, 20-35, 20- 30, 20-25, 25-35, or 25-30.

[0084] In some aspects, the bioactive glasses comprise B2O3 in an amount of 0 wt.% or greater than 0 wt.%. In some aspects, the bioactive glasses comprise B2O3 in an amount of 5 wt.% or less. In some aspects, the bioactive glasses comprise B2O3 in an amount (wt.%) of 0-5, 0-4.5, 0-4, 0-3.5, 0-3, 0-2.5, 0-2, 0-1.5, 0-1, 0-0.5, 0-0.4, 0-0.3, 0-0.2, 0-0.1, 0-0.05, >0-5, >0-4.5, >0-4, >0-3.5, >0-3, >0-2.5, >0-2, >0-1.5, >0-1, >0-0.5, >0-0.4, >0-0.3, >0-0.2, >0-0.1, >0-0.05, 0.05-5, 0.05-4.5, 0.05-4, 0.05-3.5, 0.05-3, 0.05-2.5, 0.05-2, 0.05-1.5, 0.05-1, 0.05-0.5, 0.05-0.4, 0.05-0.3, 0.05-0.2, 0.05-0.1, 0.1-5, 0.1-4.5, 0.1-4, 0.1-3.5, 0.1-3, 0.1-2.5, 0.1-2, 0.1-1.5, 0.1-1, 0.1-0.5, 0.1-0.4, 0.1-0.3, 0.1-0.2, 0.2-5, 0.2-4.5, 0.2-4, 0.2-3.5, 0.2-3, 0.2-2.5, 0.2-2, 0.2-1.5, 0.2-1, 0.2-0.5, 0.2-0.4, 0.2-0.3, 0.3-5, 0.3-4.5, 0.3-4, 0.3-3.5, 0.3-3, 0.3-2.5, 0.3-2, 0.3-1.5, 0.3-1, 0.3-0.5, 0.3-0.4, 0.4-5, 0.4-4.5, 0.4-4, 0.4-3.5, 0.4-3, 0.4-2.5, 0.4-2, 0.4-1.5, 0.4-1, 0.4-0.5, 0.5-5, 0.5-4.5, 0.5-4, 0.5-3.5, 0.5-3, 0.5-2.5, 0.5-2, 0.5-1.5, 0.5-1, 1-5, 1-4.5, 1-4, 1-3.5, 1-3, 1-2.5, 1-2, 1-1.5, 1.5-5, 1.5-4.5, 1.5-4, 1.5-3.5, 1.5-3, 1.5-2.5,1.5-2, 2-5, 2-4.5, 2-4, 2-3.5, 2-3, 2-2.5, 2.5-5, 2.5-4.5, 2.5-4, 2.5-3.5, 2.5-3, 3-5, 3-4.5, 3-4, 3-3.5, 3.5- 5, 3.5-4.5, 3.5-4, 4-5, 4-4.5, or 4.5-5. In some aspects, the bioactive glass is substantially free of, or does not contain, B2O3.

[0085] In some aspects, the bioactive glasses can comprise AI2O3. In some aspects, AI2O3 may influence (e.g., stabilize) the network structure of the glass, improve mechanical properties, improve chemical durability, or any combination thereof. In some aspects, AI2O3 may lower liquidus temperature, lower coefficient of thermal expansion, enhance the strain point, or any combination thereof. In some aspects, in addition to its role as a network former, AI2O3 (and ZrO?) may help improve the chemical durability and mechanical properties in silicate glass while having no toxicity concerns. In some aspects, too high a content of AI2O3 or ZrO? (e.g., >20 wt.%) generally increases the viscosity of the melt and decreases bioactivity.

[0086] In some aspects, the bioactive glasses comprise AI2O3 in an amount of 0 wt.% or greater than 0 wt.%. In some aspects, the bioactive glasses comprise AI2O3 in an amount of 5 wt.% or less. In some aspects, the bioactive glasses comprise AI2O3 in an amount (wt.%) of 0-5, 0-4.5, 0-4, 0-3.5, 0-3, 0-2.5, 0-2, 0-1.5, 0-1, 0-0.5, 0-0.4, 0-0.3, 0-0.2, 0-0.1, 0-0.05, >0-5, >0-4.5, >0-4, >0-3.5, >0-3, >0-2.5, >0-2, >0-1.5, >0-1, >0-0.5, >0-0.4, >0-0.3, >0-0.2, >0-0.1, >0-0.05, 0.05-5, 0.05-4.5, 0.05-4, 0.05-3.5, 0.05-3, 0.05-2.5, 0.05-2, 0.05-1.5, 0.05-1, 0.05-0.5, 0.05-0.4, 0.05-0.3, 0.05-0.2, 0.05-0.1, 0.1-5, 0.1-4.5, 0.1-4, 0.1-3.5, 0.1-3, 0.1-2.5, 0.1-2, 0.1-1.5, 0.1-1, 0.1-0.5, 0.1-0.4, 0.1-0.3, 0.1-0.2, 0.2-5, 0.2-4.5, 0.2-4, 0.2-3.5, 0.2-3, 0.2-2.5, 0.2-2, 0.2-1.5, 0.2-1, 0.2-0.5, 0.2-0.4, 0.2-0.3, 0.3-5, 0.3-4.5, 0.3-4, 0.3-3.5, 0.3-3, 0.3-2.5, 0.3-2, 0.3-1.5, 0.3-1, 0.3-0.5, 0.3-0.4, 0.4-5, 0.4-4.5, 0.4-4, 0.4-3.5, 0.4-3, 0.4-2.5, 0.4-2, 0.4-1.5, 0.4-1, 0.4-0.5, 0.5-5, 0.5-4.5, 0.5-4, 0.5-3.5, 0.5-3, 0.5-2.5, 0.5-2, 0.5-1.5, 0.5-1, 1-5, 1-4.5, 1-4, 1-3.5, 1-3, 1-2.5, 1-2, 1-1.5, 1.5-5, 1.5-4.5, 1.5-4, 1.5-3.5, 1.5-3, 1.5-2.5, 1.5-2, 2-5, 2-4.5, 2-4, 2-3.5, 2-3, 2-2.5, 2.5-5, 2.5-4.5, 2.5-4, 2.5-3.5, 2.5-3, 3-5, 3-4.5, 3-4, 3-3.5, 3.5- 5, 3.5-4.5, 3.5-4, 4-5, 4-4.5, or 4.5-5. In some aspects, the bioactive glass is substantially free of, or does not contain, AI2O3.

[0087] In some aspects, alkali oxides (Na2O, K2O, Li2O, Rb2O, or CS2O) serve as aids in achieving low melting temperature and low liquidus temperatures, which can aid glass melting processes. In addition, in some aspects, the addition of alkali oxides can improve bioactivity. However, in some aspects, if the amount of alkali oxides is too high, the bioactive glasses have reduced chemical durability; in other words, in some aspects, keeping the amount of alkali oxides to a certain lower range achieves high chemical durability of the bioactive glasses. In some aspects, the amount of alkali oxides, such as Na2O+K2O+Li2O, is minimized or at least kept to an amount below 10 wt.% or below 5 wt.%, so as to improve durability of the bioactive glass in aqueous compositions, such as in water. In some aspects, the bioactive glasses do not contain any alkali oxides (e.g., do not contain any added alkali oxides). In some aspects, the bioactive glasses are substantially free of alkali oxides (e.g., contain less than 0. 1 wt.% alkali oxides).

[0088] In some aspects, the bioactive glasses comprise Li2O in an amount of 0 wt.% or greater than 0 wt.%. In some aspects, the bioactive glasses comprise Li2O in an amount of 10 wt.% or less. In some aspects, the bioactive glasses comprise Li2O in an amount (wt.%) of 0-10, 0-9, 0-8, 0-7, 0-6, 0- 5, 0-4, 0-3, 0-2, 0-1, 0-0.5, 0-0.1, >0-10, >0-9, >0-8, >0-7, >0-6, >0-5, >0-4, >0-3, >0-2, >0-1, >0-0.5, >0-0.1, 0.1-10, 0.1-9, 0.1-8, 0.1-7, 0.1-6, 0.1-5, 0.1-4, 0.1-3, 0.1-2, 0.1-1, 0.1-0.5, 0.5-10, 0.5-9, 0.5-8, 0.5-7, 0.5-6, 0.5-5, 0.5-4, 0.5-3, 0.5-2, 0.5-1, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, 2-10, 2-9, 2-8, 2-7, 2-6, 2-5, 2-4, 2-3, 3-10, 3-9, 3-8, 3-7, 3-6, 3-5, 3-4, 4-10, 4-9, 4-8, 4-7, 4-6, 4-5, 5-10, 5-9, 5-8, 5- 7, 5-6, 6-10, 6-9, 6-8, 6-7, 7-10, 7-9, 7-8, 8-10, 8-9, or 9-10. In some aspects, the bioactive glass is substantially free of, or does not contain, Li2O.

[0089] In some aspects, the bioactive glasses comprise Na2O in an amount of 0 wt.% or greater than 0 wt.%. In some aspects, the bioactive glasses comprise Na2O in an amount of 10 wt.% or less. In some aspects, the bioactive glasses comprise Na2O in an amount (wt.%) of 0-10, 0-9, 0-8, 0-7, 0-6, 0-5, 0-4, 0-3, 0-2, 0-1, 0-0.5, 0-0.1, >0-10, >0-9, >0-8, >0-7, >0-6, >0-5, >0-4, >0-3, >0-2, >0-1, >0-0.5, >0-0.1, 0.1-10, 0.1-9, 0.1-8, 0.1-7, 0.1-6, 0.1-5, 0.1-4, 0.1-3, 0.1-2, 0.1-1, 0.1-0.5, 0.5-10, 0.5-9, 0.5-8, 0.5-7, 0.5-6, 0.5-5, 0.5-4, 0.5-3, 0.5-2, 0.5-1, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, 2-10, 2-9, 2-8, 2-7, 2-6, 2-5, 2-4, 2-3, 3-10, 3-9, 3-8, 3-7, 3-6, 3-5, 3-4, 4-10, 4-9, 4-8, 4-7, 4-6, 4-5, 5-10, 5-9, 5-8, 5- 7, 5-6, 6-10, 6-9, 6-8, 6-7, 7-10, 7-9, 7-8, 8-10, 8-9, or 9-10. In some aspects, the bioactive glass is substantially free of, or does not contain, Na2O.

[0090] In some aspects, the bioactive glasses comprise K2O in an amount of 0 wt.% or greater than 0 wt.%. In some aspects, the bioactive glasses comprise K2O in an amount of 10 wt.% or less. In some aspects, the bioactive glasses comprise K2O in an amount (wt.%) of 0-10, 0-9, 0-8, 0-7, 0-6, 0-5, 0-4, 0-3, 0-2, 0-1, 0-0.5, 0-0.1, >0-10, >0-9, >0-8, >0-7, >0-6, >0-5, >0-4, >0-3, >0-2, >0-1, >0-0.5, >0- 0.1, 0.1-10, 0.1-9, 0.1-8, 0.1-7, 0.1-6, 0.1-5, 0.1-4, 0.1-3, 0.1-2, 0.1-1, 0.1-0.5, 0.5-10, 0.5-9, 0.5-8, 0.5-7, 0.5-6, 0.5-5, 0.5-4, 0.5-3, 0.5-2, 0.5-1, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, 2-10, 2-9, 2-8, 2-7, 2-6, 2-5, 2-4, 2-3, 3-10, 3-9, 3-8, 3-7, 3-6, 3-5, 3-4, 4-10, 4-9, 4-8, 4-7, 4-6, 4-5, 5-10, 5-9, 5-8, 5- 7, 5-6, 6-10, 6-9, 6-8, 6-7, 7-10, 7-9, 7-8, 8-10, 8-9, or 9-10. In some aspects, the bioactive glass is substantially free of, or does not contain, K2O.

[0091] In some aspects, the bioactive glasses comprise the sum Li2O+ Na2O+ K2O in an amount of 0 wt.% or greater than 0 wt.%. In some aspects, the bioactive glasses comprise the sum Li2O+ Na2O+ K2O in an amount of 10 wt.% or less or 5 wt.% or less. In some aspects, the bioactive glasses comprise the sum Li2O+ Na2O+ K2O in an amount (wt.%) of 0-10, 0-9, 0-8, 0-7, 0-6, 0-5, 0-4, 0-3, 0- 2, 0-1, 0-0.5, 0-0.1, >0-10, >0-9, >0-8, >0-7, >0-6, >0-5, >0-4, >0-3, >0-2, >0-1, >0-0.5, >0-0.1, 0.1- 10, 0.1-9, 0.1-8, 0.1-7, 0.1-6, 0.1-5, 0.1-4, 0.1-3, 0.1-2, 0.1-1, 0.1-0.5, 0.5-10, 0.5-9, 0.5-8, 0.5-7, 0.5-6, 0.5-5, 0.5-4, 0.5-3, 0.5-2, 0.5-1, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, 2-10, 2-9, 2-8, 2-7, 2-6, 2-5, 2-4, 2-3, 3-10, 3-9, 3-8, 3-7, 3-6, 3-5, 3-4, 4-10, 4-9, 4-8, 4-7, 4-6, 4-5, 5-10, 5-9, 5-8, 5-7, 5-6, 6-10, 6-9, 6-8, 6-7, 7-10, 7-9, 7-8, 8-10, 8-9, or 9-10. In some aspects, the bioactive glasses comprise the sum Na2O+K2O+Li2O+Rb2O+Cs2O in any of the amounts set forth in this paragraph.

[0092] In some aspects, additional components can be incorporated into the bioactive glasses to provide additional benefits or may be incorporated as contaminants typically found in commercially- prepared glass. For example, additional components can be added as coloring or fining agents (e.g., to facilitate removal of gaseous inclusions from melted batch materials used to produce the bioactive glasses) and / or for other purposes. In some aspects, the bioactive glasses may comprise one or more compounds useful as ultraviolet radiation absorbers. In some aspects, the bioactive glasses can comprise 3 wt.% or lessSb2O3, Cl, Br, or any combination thereof. In some aspects, the bioactive glasses can comprise from 0 to 3 wt.%, 0 to 2 wt.%, 0 to 1 wt.%, 0 to 0.5 wt.%, 0 to 0.1 wt.%, 0 to 0.05 wt.%, or 0 to 0.01 wt.% ZnO, TiO2, CeO, MnO, bfr^Os, MoOs, Ta2Os, WO3, SnO2, Fe2O3, AS2O3, Sb2O3, Cl, Br, or any combination thereof. In some aspects, the bioactive glasses can also include various contaminants associated with batch materials and / or introduced into the glass by the melting, fining, and / or forming equipment used to produce the glass. For example, in some aspects, the bioactive glasses can comprise from 0 to 3 wt.%, 0 to 2 wt.%, 0 to 1 wt.%, 0 to 0.5 wt.%, 0 to 0.1 wt.%, 0 to 0.05 wt.%, or 0 to 0.01 wt.% SnO2, CeCh, Fe2C>3, or a combination thereof.

[0093] In some aspects, the bioactive glass can comprise CeC>2. For example, in some aspects, the bioactive glass is doped with CeC>2. In particular, in some aspects, the bioactive glasses can comprise CeC>2 in an amount (wt.%) of 0, >0, at least 0.1, at least 0.2, at least 0.4, at least 0.6, at least 0.8, at least 1, at least 1.2, at least 1.4, at least 1.6, at least 1.8, 2 or less, 1.8 or less, 1.6 or less, 1.4 or less, 1.2 or less, 1 or less, 0.8 or less, 0.6 or less, 0.4 or less, 0.2 or less, 0.1 or less, or any range formed therefrom. For example, in some aspects, the bioactive glasses can comprise CeC>2 in an amount (wt.%) of 0-2, 0-1.8, 0-1.6, 0-1.4, 0-1.2, 0-1, 0-0.8, 0-0.6, 0-0.4, 0-0.2, 0-0.1, >0-2, >0-1.8, >0-1.6, >0-1.4, >0-1.2, >0-1, >0-0.8, >0-0.6, >0-0.4, >0-0.2, >0-0.1, 0.1-2, 0.1-1.8, 0. 1-1.6, 0.1-1.4, 0.1-1.2, 0.1-1, 0.1-0.8, 0.1-0.6, 0.1-0.4, 0.1-0.2, 0.2-2, 0.2-1.8, 0.2-1.6, 0.2-1.4, 0.2-1.2, 0.2-1, 0.2-0.8, 0.2-0.6, 0.2-0.4, 0.4-2, 0.4-1.8, 0.4-1.6, 0.4-1.4, 0.4-1.2, 0.4-1, 0.4-0.8, 0.4-0.6, 0.6-2, 0.6-1.8, 0.6-1.6, 0.6-1.4, 0.6-1.2, 0.6-1, 0.6-0.8, 0.8-2, 0.8-1.8, 0.8-1.6, 0.8-1.4, 0.8-1.2, 0.8-1, 1-2, 1-1.8, 1-1.6, 1-1.4, 1-1.2, 1.2-2, 1.2-1.8, 1.2-1.6, 1.2-1.4, 1.4-2, 1.4-1.8, 1.4-1.6, 1.6-2, 1.6-1.8, or 1.8-2. In some aspects, the bioactive glass is substantially free of, or does not contain, CeC>2.

[0094] In some aspects, the bioactive glass is substantially free of, or does not contain, a crystalline phase. For example, in some aspects, the bioactive glass has a glassy phase and no crystalline phase. In some aspects, the bioactive glass is a glass (e.g., a glass article). In some aspects, the bioactive glass contains a crystalline phase. In some aspects, the bioactive glass is a glass-ceramic (e.g., a glassceramic article).

[0095] In some aspects, the bioactive glass is in a form of particulates, microbeads, fibers, or a combination thereof. In some aspects, the particulates are a fine powder. Methods for preparing particulates, microbeads, and / or fibers from bioactive glasses is known in the art. In some aspects, the particulates, microbeads, and / or fibers have an average particle size of at least 1 micron. In some aspects, the particulates and / or microbeads have an average particle size of 50 microns or less. In some aspects, the particulates and / or microbeads have an average particle size (microns) of 1-50, 1- 45, 1-40, 1-35, 1-30, 1-25, 1-20, 1-15, 1-10, 1-5, 5-50, 5-45, 5-40, 5-35, 5-30, 5-25, 5-20, 5-15, 5-10, 10-50, 10-45, 10-40, 10-35, 10-30, 10-25, 10-20, 10-15, 15-50, 15-45, 15-40, 15-35, 15-30, 15-25, 15- 20, 20-50, 20-45, 20-40, 20-35, 20-30, 20-25, 25-50, 25-45, 25-40, 25-35, 25-30, 30-50, 30-45, 30-40, 30-35, 35-50, 35-45, 35-40, 40-50, 40-45, or 45-50. Average particle size, as used herein, means the average size as measured by dynamic light scattering using commercially available equipment.

[0096] In some aspects, when the bioactive glass is subjected to a composition at 37 °C and a pH of 6.5 to form a mixture, a total amount of calcium ions in the mixture increases every 2 hours over a 12 hour period, wherein the composition comprises 0.05 wt.% sodium chloride, 0.1 wt.% urea, 0. 1 wt.% lactic acid, and a balance of water. See, for example, FIG. 1.

[0097] In some aspects, the bioactive glasses can be made via traditional methods. For example, in some aspects, precursor glasses can be formed by thoroughly mixing the requisite batch materials (for example, using a Turbula® mixer) in order to secure a homogeneous melt, and subsequently placing into silica and / or platinum crucibles. The crucibles can be placed into a furnace and the glass batch melted and maintained at temperatures ranging from 1100°C to 1400°C for times ranging from 6 hours to 24 hours. The melts can thereafter be poured into steel molds to yield glass slabs.Subsequently, those slabs optionally can be transferred immediately to an annealer operating at 400°C to 700°C, where the glass is held at temperature for 0.5 hour to 3 hours and subsequently cooled overnight. In another non-limiting example, precursor glasses are prepared by dry blending the appropriate oxides and mineral sources for a time sufficient to thoroughly mix the ingredients. The glasses are melted in platinum crucibles at temperatures ranging from 1100°C to 1400°C and held at temperature for 6 hours to 16 hours. The resulting glass melts are then poured onto a steel table to cool. The precursor glasses optionally are then annealed at appropriate temperatures.

[0098] In some aspects, the resulting bioactive glasses can be ground into fine particles in the range of 1-10 microns (pm) by air jet milling. The particle size can be varied in the range of 1-100 pm using attrition milling or ball milling of glass frits. Furthermore, these glasses can be processed into short fibers, beads, sheets or three-dimensional scaffolds using different methods. Short fibers are made by melt spinning or electric spinning; beads can be produced by flowing glass particles through a hot vertical furnace or a flame torch; sheets can be manufactured using thin rolling, float or fusion-draw processes; and scaffolds can be produced using rapid prototyping, polymer foam replication andparticle sintering. Glasses of desired forms can be used to support cell growth, soft and hard tissue regeneration, stimulation of gene expression or angiogenesis.

[0099] Continuous fibers can be easily drawn from the disclosed composition using processes known in the art. For example, fibers can be formed using a directly heated (electricity passing directly through) platinum bushing. Glass cullet is loaded into the bushing, heated up until the glass can melt. Temperatures are set to achieve a desired glass viscosity (usually <1000 poise) allowing a drip to form on the orifice in the bushing (Bushing size is selected to create a restriction that influences possible fiber diameter ranges). The drip is pulled by hand to begin forming a fiber. Once a fiber is established it is connected to a rotating pulling / collection drum to continue the pulling process at a consistent speed. Using the drum speed (or revolutions per minute RPM) and glass viscosity the fiber diameter can be manipulated - in general the faster the pull speed, the smaller the fiber diameter. Glass fibers with diameters in the range of 1-100 pm can be drawn continuously from a glass melt. Fibers can also be created using an updraw process. In this process, fibers are pulled from a glass melt surface sitting in a box furnace. By controlling the viscosity of the glass, a quartz rod is used to pull glass from the melt surface to form a fiber. The fiber can be continuously pulled upward to increase the fiber length. The velocity that the rod is pulled up determines the fiber thickness along with the viscosity of the glass.

[0100] Therefore, in some aspects, a method for making the bioactive glasses disclosed herein is provided, the method comprising: combining each component of the bioactive glass to form a mixture, heating the mixture to a temperature of 1500 °C or less to form a melted mixture, and cooling the melted mixture to form a cooled mixture.

[0101] In some aspects, the method further comprising forming the cooled mixture, or the melted mixture prior to and / or during cooling, into particulates, microbeads, fibers, or a combination thereof.

[0102] In some aspects, the cosmetic compositions comprise bioactive glass in any suitable amount. In some aspects, the cosmetic compositions comprise bioactive glass in an amount (wt.%) of 0, >0, at least 0.1, at least 0.2, at least 0.4, at least 0.6, at least 0.8, at least 1, at least 2, at least 3, at least 4, at least 5, at least 6, at least 8, at least 10, at least 12, at least 14, at least 16, at least 18, 20 or less, 18 or less, 16 or less, 14 or less, 12 or less, 10 or less, 8 or less, 6 or less, 5 or less, 4 or less, 3 or less, 2 or less, 1 or less, 0.8 or less, 0.6 or less, 0.4 or less, 0.2 or less, 0. 1 or less, or any range formed therefrom, based on total weight of the cosmetic composition. For example, in some aspects, the cosmetic compositions comprise bioactive glass in an amount (wt.%) of 0-20, 0-18, 0-16, 0-14, 0-12, 0-10, 0-8, 0-6, 0-5, 0-4, 0-3, 0-2, 0-1, 0-0.8, 0-0.6, 0-0.4, 0-0.2, 0-0.1, >0-20, >0-18, >0-16, >0-14, >0-12, >0-10, >0-8, >0-6, >0-5, >0-4, >0-3, >0-2, >0-1, >0-0.8, >0-0.6, >0-0.4, >0-0.2, >0-0.1, 0.1- 20, 0.1-18, 0.1-16, 0.1-14, 0.1-12, 0.1-10, 0.1-8, 0.1-6, 0.1-5, 0.1-4, 0.1-3, 0.1-2, 0.1-1, 0.1-0.8, 0.1- 0.6, 0.1-0.4, 0.1-0.2, 0.2-20, 0.2-18, 0.2-16, 0.2-14, 0.2-12, 0.2-10, 0.2-8, 0.2-6, 0.2-5, 0.2-4, 0.2-3,0.2-2, 0.2-1, 0.2-0.8, 0.2-0.6, 0.2-0.4, 0.4-20, 0.4-18, 0.4-16, 0.4-14, 0.4-12, 0.4-10, 0.4-8, 0.4-6, 0.4-5, 0.4-4, 0.4-3, 0.4-2, 0.4-1, 0.4-0.8, 0.4-0.6, 0.6-20, 0.6-18, 0.6-16, 0.6-14, 0.6-12, 0.6-10, 0.6-8, 0.6-6, 0.6-5, 0.6-4, 0.6-3, 0.6-2, 0.6-1, 0.6-0.8, 0.8-20, 0.8-18, 0.8-16, 0.8-14, 0.8-12, 0.8-10, 0.8-8, 0.8-6, 0.8-5, 0.8-4, 0.8-3, 0.8-2, 0.8-1, 1-20, 1-18, 1-16, 1-14, 1-12, 1-10, 1-8, 1-6, 1-5, 1-4, 1-3, 1-2, 2-20,2-18, 2-16, 2-14, 2-12, 2-10, 2-8, 2-6, 2-5, 2-4, 2-3, 3-20, 3-18, 3-16, 3-14, 3-12, 3-10, 3-8, 3-6, 3-5,3-4, 4-20, 4-18, 4-16, 4-14, 4-12, 4-10, 4-8, 4-6, 4-5, 5-20, 5-18, 5-16, 5-14, 5-12, 5-10, 5-8, 5-6, 6- 20, 6-18, 6-16, 6-14, 6-12, 6-10, 6-8, 8-20, 8-18, 8-16, 8-14, 8-12, 8-10, 10-20, 10-18, 10-16, 10-14, 10-12, 12-20, 12-18, 12-16, 12-14, 14-20, 14-18, 14-16, 16-20, 16-18, or 18-20, based on total weight of the cosmetic compositions. In some aspects, the cosmetic compositions comprise bioactive glass in an amount of >0-5 wt.%, 0.1-10 wt.%, 1-8 wt.%, or 12-20 wt.%, based on total weight of the cosmetic composition.

[0103] In some aspects, the cosmetic compositions and / or carriers comprise amino acid in any suitable amount. In some aspects, the cosmetic compositions and / or carriers comprise amino acid in an amount of 0, >0, at least 0. 1, at least 0.5, at least 1, at least 2, at least 4, at least 6, at least 8, at least 10, at least 12, at least 14, at least 18, at least 20, at least 22, 25 or less, 22 or less, 20 or less, 18 or less, 16 or less, 14 or less, 12 or less, 10 or less, 8 or less, 6 or less, 4 or less, 2 or less, 1 or less, 0.5 or less, 0.1 or less, or any range formed therefrom, based no total weight of the cosmetic composition. In some aspects, the cosmetic compositions and / or carriers comprise amino acid in an amount (wt.%) of 0-25, 0-24, 0-22, 0-20, 0-18, 0-16, 0-14, 0-12, 0-10, 0-8, 0-6, 0-4, 0-2, 0-1, 0-0.5, 0-0.1, >0-25, >0-24, >0-22, >0-20, >0-18, >0-16, >0-14, >0-12, >0-10, >0-8, >0-6, >0-4, >0-2, >0-1, >0-0.5, >0-0.1, 0.1- 25, 0.1-24, 0.1-22, 0.1-20, 0.1-18, 0.1-16, 0.1-14, 0.1-12, 0.1-10, 0.1-8, 0.1-6, 0.1-4, 0.1-2, 0.1-1, 0.1- 0.5, 0.5-25, 0.5-24, 0.5-22, 0.5-20, 0.5-18, 0.5-16, 0.5-14, 0.5-12, 0.5-10, 0.5-8, 0.5-6, 0.5-4, 0.5-2, 0.5-1, 1-25, 1-24, 1-22, 1-20, 1-18, 1-16, 1-14, 1-12, 1-10, 1-8, 1-6, 1-4, 1-2, 2-25, 2-24, 2-22, 2-20, 2-18, 2-6, 2-14, 2-12, 2-10, 2-8, 2-6, 2-4, 4-25, 4-24, 4-22, 4-20, 4-18, 4-16, 4-14, 4-12, 4-10, 4-8, 4- 6, 6-25, 6-24, 6-22, 6-20, 6-18, 6-16, 6-14, 6-12, 6-10, 6-8, 8-25, 8-24, 8-22, 8-20, 8-18, 8-16, 8-14, 8- 12, 8-10, 10-25, 10-24, 10-22, 10-20, 10-18, 10-16, 10-14, 10-12, 12-25, 12-24, 12-22, 12-20, 12-18, 12-16, 12-14, 14-25, 14-24, 14-22, 14-20, 14-18, 14-16, 16-25, 16-24, 16-22, 16-20, 16-18, 18-25, 18- 24, 18-22, 18-20, 20-25, 20-24, 20-22, 22-25, 22-24, or 24-25, based on total weight of the cosmetic composition. In some aspects, the cosmetic compositions are free, or substantially free, of amino acid. The amounts herein may refer to a total amount of all amino acids present, or to any individual amino acid, as may be specified for a given context. In some aspects, the cosmetic compositions and / or carriers do not contain a detectable amount of an amino acid, as measured by high performance liquid chromatography (HPLC). The “detectable amount” of amino acid can refer to one or more specific amino acids, or any amino acid whatsoever, and any such amino acids for measurement by HPLC can be selected from any of those specific amino acids disclosed elsewhere herein.

[0104] In some aspects, suitable amino acids for inclusion in cosmetic compositions and / or carriers herein include arginine, histidine, lysine, pyrrolysine, aspartic acid, serine, threonine, asparagine, glutamine, cysteine, selenocysteine, proline, alanine, valine, isoleucine, leucine, methionine, phenylalanine, tyrosine, tryptophan, or any combination thereof. In some aspects, cosmetic compositions and / or carriers do not contain a detectable amount of arginine, histidine, lysine, pyrrolysine, aspartic acid, serine, threonine, asparagine, glutamine, cysteine, selenocysteine, proline, alanine, valine, isoleucine, leucine, methionine, phenylalanine, tyrosine, tryptophan, or any combination thereof, by HPLC. In some aspects, cosmetic compositions and / or carriers contain arginine. In some aspects, cosmetic compositions and / or carriers do not contain a detectable amount of arginine by HPLC. In some aspects, cosmetic compositions and / or carriers contain glycine, glutamic acid, or a combination thereof. In some aspects, cosmetic compositions and / or carriers do not contain a detectable amount of glycine or glutamic acid by HPLC.

[0105] In some aspects, the cosmetic compositions disclosed herein can be in any suitable form. For example, in some aspects, the cosmetic compositions are (or are in the form of) a toner, a lotion, a moisturizer, a serum, a sensitive skin care formulation, a sunscreen, a lotion primer, a gel foundation, a powder foundation, a concealer, a face powder, a gel, a spray, an ointment, a salve, a cream, a bandage, or a transdermal formulation, or any other formulation that is intended for cosmetic purposes, such as skin or hair care.

[0106] In some aspects, the cosmetic compositions are a toner, and the carrier comprises a skin soothing agent, a mineral, a rheology modifier, a humectant, a preservative, and a diluent, optionally in combination with one or more other carrier components disclosed elsewhere herein. In some aspects, the skin soothing agent of the toner comprises botanic extracts, optionally in combination with one or more other skin soothing agents disclosed elsewhere herein. In some aspects, the mineral of the toner comprises magnesium chloride, calcium chloride, or a combination thereof, optionally in combination with one or more other minerals disclosed elsewhere herein. In some aspects, the rheology modifier of the toner comprises hydroxypropyl guar, optionally in combination with one or more other rheology modifiers disclosed elsewhere herein. In some aspects, the humectant of the toner comprises sodium hyaluronate, saccharide isomerate, or a combination thereof, optionally in combination with one or more other humectants disclosed elsewhere herein. In some aspects, the preservative of the toner comprises phenoxyethanol, sorbic acid, caprylyl glycol, or any combination thereof, optionally in combination with one or more other preservatives disclosed elsewhere herein. In some aspects, the diluent of the toner comprises water, optionally in combination with one or more other diluents disclosed elsewhere herein.

[0107] In some aspects, the cosmetic compositions are a lotion, and the carrier comprises a humectant, an emollient, an emulsifier, a preservative, and a diluent, optionally in combination with one or more other carrier components disclosed elsewhere herein. In some aspects, the humectant ofthe lotion comprises glycerin, sodium hyaluronate, sodium lauroyl lactylate, or any combination thereof, optionally in combination with one or more other humectants disclosed elsewhere herein. In some aspects, the emollient of the lotion comprises caprylic / capric triglycerides, cetyl alcohol, ceramide, phytosphiosine, or any combination thereof, optionally in combination with one or more other emollients disclosed elsewhere herein. In some aspects, the emulsifier of the lotion comprises cetearyl alcohol, ceteareth-20, behentrimonium methosulfate, or any combination thereof, optionally in combination with one or more other emulsifiers disclosed elsewhere herein. In some aspects, the preservative of the lotion comprises phenoxyethanol, sorbic acid, caprylyl glycol, or any combination thereof, optionally in combination with one or more other preservatives disclosed elsewhere herein. In some aspects, the diluent of the lotion comprises water.

[0108] In some aspects, the cosmetic compositions are a moisturizer, and the carrier comprises an emulsifier, a humectant, an emollient, a rheology modifier, a preservative, and a diluent, optionally in combination with one or more other carrier components disclosed elsewhere herein. In some aspects, the emulsifier of the moisturizer comprises behenyl alcohol, polyglyceryl-3 stearate, glyceryl stearate, cetearyl alcohol, cetearyl glucoside, or any combination thereof, optionally in combination with one or more other emulsifiers disclosed elsewhere herein. In some aspects, the humectant of the moisturizer comprises glycerin, optionally in combination with one or more other humectants disclosed elsewhere herein. In some aspects, the emollient of the moisturizer comprises squalene, caprylic / capric triglycerides, ceramide, or any combination thereof, optionally in combination with one or more other emollients disclosed elsewhere herein. In some aspects, the rheology modifier of the moisturizer comprises cetyl palmitate, optionally in combination with one or more other rheology modifiers disclosed elsewhere herein. In some aspects, the preservative of the moisturizer comprises 1,2- hexanediol, caprylyl glycol, or a combination thereof, optionally in combination with one or more other preservatives disclosed elsewhere herein. In some aspects, the diluent of the moisturizer comprises water, optionally in combination with one or more other diluents disclosed elsewhere herein.

[0109] In some aspects, the cosmetic compositions are a serum, and the carrier comprises a humectant, an antioxidant, an emollient, a rheology modifier, a stabilizer, a preservative, a skin soothing agent, and a diluent, optionally in combination with one or more other carrier components disclosed elsewhere herein. In some aspects, the humectant of the serum comprises sodium hyaluronate, optionally in combination with one or more other humectants disclosed elsewhere herein. In some aspects, the antioxidant of the serum comprises vitamin E, provitamin B5, or a combination thereof, optionally in combination with one or more other antioxidants disclosed elsewhere herein. In some aspects, the emollient of the serum comprises squalene, seed oils, caprylic / capric triglycerides, ceramide, or any combination thereof, optionally in combination with one or more other emollients disclosed elsewhere herein. In some aspects, the rheology modifier of the serum comprises xanthan gum, optionally in combination with one or more other rheology modifiers disclosed elsewhere herein.In some aspects, the stabilizer of the serum comprises sodium gluconate, optionally in combination with one or more other stabilizers disclosed elsewhere herein. In some aspects, the preservative of the serum comprises 1,2-hexanediol, caprylyl glycol, or a combination thereof, optionally in combination with one or more other preservatives disclosed elsewhere herein. In some aspects, the skin soothing agent of the serum comprises botanic extracts, optionally in combination with one or more other skin soothing agents disclosed elsewhere herein. In some aspects, the diluent of the serum comprises water, optionally in combination with one or more other diluents disclosed elsewhere herein.

[0110] In some aspects, the cosmetic compositions are a sensitive skin care formulation, and the carrier comprises a humectant, an emollient, a rheology modifier, an emulsifier, an antioxidant, a preservative, and a diluent, optionally in combination with one or more other carrier components disclosed elsewhere herein. In some aspects, the humectant of the sensitive skin care formulation comprises sorbitol, optionally in combination with one or more other humectants disclosed elsewhere herein. In some aspects, the emollient of the sensitive skin care formulation comprises botanic extract oils, caprylic / capric triglycerides, cetyl alcohol, ceramide, or any combination thereof, optionally in combination with one or more other emollients disclosed elsewhere herein. In some aspects, the rheology modifier of the sensitive skin care formulation comprises botanic extract buffers, cetearyl alcohol, polysorbate 60, xanthan gum, or any combination thereof, optionally in combination with one or more other rheology modifiers disclosed elsewhere herein. In some aspects, the emulsifier of the sensitive skin care formulation comprises sodium acrylate, isohexadecane, polysorbate 80, cetearyl glucoside, or any combination thereof, optionally in combination with one or more other emulsifiers disclosed elsewhere herein. In some aspects, the antioxidant of the sensitive skin care formulation comprises vitamin E, optionally in combination with one or more other antioxidants disclosed elsewhere herein. In some aspects, the preservative of the sensitive skin care formulation comprises benzyl alcohol, optionally in combination with one or more other preservatives disclosed elsewhere herein. In some aspects, the diluent of the sensitive skin care formulation comprises water, optionally in combination with one or more other diluents disclosed elsewhere herein.

[0111] In some aspects, the cosmetic compositions are sunscreens, and the carrier comprises a sun filter, a rheology modifier, an emollient, an emulsifier, a preservative, and a diluent, optionally in combination with one or more other carrier components disclosed elsewhere herein. In some aspects, the sun filter of the sunscreen comprises titanium dioxide, zinc oxide, or a combination thereof, optionally in combination with one or more other sun filters disclosed elsewhere herein. In some aspects, the rheology modifier of the sunscreen comprises silica, alumina, PEG-30 dipolyhydroxystearate, wax, or any combination thereof, optionally in combination with one or more other rheology modifiers disclosed elsewhere herein. In some aspects, the emollient of the sunscreen comprises caprylic / capric triglyceride, isohexadecane, isononyl isononanoate, ceramide, or any combination thereof, optionally in combination with one or more other emollients disclosed elsewhereherein. In some aspects, the emulsifier of the sunscreen comprises sodium lauroyl lactylate, glyceryl stearate, cetearyl alcohol, cetearyl glucoside, or any combination thereof, optionally in combination with one or more other emulsifiers disclosed elsewhere herein. In some aspects, the preservative of the sunscreen comprises behentrimonium methosulfate, optionally in combination with one or more other preservatives disclosed elsewhere herein. In some aspects, the diluent of the sunscreen comprises water, optionally in combination with one or more other diluent disclosed elsewhere herein.

[0112] In some aspects, the cosmetic compositions are lotion primers, and the carrier comprises a texturizer, a rheology modifier, an emollient, an emulsifier, an antioxidant, a pigment, a preservative, and a diluent, optionally in combination with one or more other carrier components disclosed elsewhere herein. In some aspects, the texturizer of the lotion primer comprises silica, optionally in combination with one or more other texturizers disclosed elsewhere herein. In some aspects, the rheology modifier of the lotion primer comprises xanthan gum, caprate, triheptanoin, dilinoleic acid, or any combination thereof, optionally in combination with one or more other rheology modifiers disclosed elsewhere herein. In some aspects, the emollient of the lotion primer comprises caprylic / capric triglyceride, stearalkonium hectorite, galactoarabinan, or any combination thereof, optionally in combination with one or more other emollients disclosed elsewhere herein. In some aspects, the emulsifier of the lotion primer comprises lecithin, polyglyceryl-4 oleate, olive sedate, or any combination thereof, optionally in combination with one or more other emulsifiers disclosed elsewhere herein. In some aspects, the antioxidant of the lotion primer comprises vitamin E, optionally in combination with one or more other antioxidants disclosed elsewhere herein. In some aspects, the pigment of the lotion primer comprises iron oxide, mica, or a combination thereof, optionally in combination with one or more other pigments disclosed elsewhere herein. In some aspects, the preservative of the lotion primer comprises benzylalcohol, dehydroacetic acid, or a combination thereof, optionally in combination with one or more other preservatives disclosed elsewhere herein. In some aspects, the diluent of the lotion primer comprises water, optionally in combination with one or more other diluents disclosed elsewhere herein.

[0113] In some aspects, the cosmetic compositions are powder foundations, and the carrier comprises a texturizer, an emollient, an antioxidant, a pigment, and a diluent, optionally in combination with one or more other carrier components disclosed elsewhere herein. In some aspects, the texturizer of the powder foundation comprises silica, boron nitride, kaolin, talc, or any combination thereof, optionally in combination with one or more other texturizers disclosed elsewhere herein. In some aspects, the emollient of the powder foundation comprises caprylic / capric triglyceride, hydrogenated polyisobutene, or a combination thereof, optionally in combination with one or more other emollients disclosed elsewhere herein. In some aspects, the antioxidant of the powder foundation comprises vitamin E, optionally in combination with one or more other antioxidants disclosed elsewhere herein. In some aspects, the pigment of the powder foundation comprises iron oxide, titanium dioxide, mica, or any combination thereof, optionally in combination with one or more other pigments disclosedelsewhere herein. In some aspects, the diluent of the powder foundation comprises seed oil, wax, starch, magnesium stearate, or any combination thereof, optionally in combination with one or more other diluents disclosed elsewhere herein.

[0114] In some aspects, the cosmetic compositions are concealers, and the carrier comprises a texturizer, an emollient, an antioxidant, a pigment, and a diluent, optionally in combination with one or more other carrier components disclosed elsewhere herein. In some aspects, the texturizer of the concealer comprises silica, talc, polymethylsilsesquioxane, dimethicone, or any combination thereof, optionally in combination with one or more other texturizers disclosed elsewhere herein. In some aspects, the emollient of the concealer comprises caprylic / capric triglyceride, polyhydroxystearic acid, isododecane, or any combination thereof, optionally in combination with one or more other emollients disclosed elsewhere herein. In some aspects, the antioxidant of the concealer comprises vitamin E, optionally in combination with one or more other antioxidants disclosed elsewhere herein. In some aspects, the pigment of the concealer comprises iron oxide, titanium dioxide, mica, or any combination thereof, optionally in combination with one or more other pigments disclosed elsewhere herein. In some aspects, the diluent of the concealer comprises seed oil, octyldodecanol, wax, or any combination thereof, optionally in combination with one or more other diluents disclosed elsewhere herein.

[0115] In some aspects, the cosmetic compositions are face powders, and the carrier comprises a texturizer, an emollient, a pigment, and a diluent, optionally in combination with one or more other carrier components disclosed elsewhere herein. In some aspects, the texturizer of the face powder comprises silica, kaolin, magnesium hydroxide, polymethylsilsesquioxane, or any combination thereof, optionally in combination with one or more other texturizers disclosed elsewhere herein. In some aspects, the emollient of the face powder comprises dimethicone, allantoin, niacinamide, or any combination thereof, optionally in combination with one or more other emollients disclosed elsewhere herein. In some aspects, the pigment of the face powder comprises iron oxide, titanium dioxide, mica, or any combination thereof, optionally in combination with one or more other pigments disclosed elsewhere herein. In some aspects, the diluent of the face powder comprises starch, pearl powder, or a combination thereof, optionally in combination with one or more other diluents disclosed elsewhere herein.

[0116] In some aspects, disclosed is a method comprising applying the cosmetic compositions to skin and / or hair. In some aspects, this method is performed by an end user, for example, by way of applying the cosmetic composition as a lotion, salve, etc., to their own skin or hair, such as hands, arms, legs, hair, and / or face. In some aspects, this method is performed by a professional, such as a doctor, a dermatologist, a beautician, or other skin or hair care professional or pseudo-professional, by way of applying the composition to a patient’s skin or hair, directing a patient to apply the composition to their skin or hair, and so forth.

[0117] In some aspects, the method treats or reduces the appearance of one or more skin defects, optionally wherein the one or more skin defects comprises wrinkles, blemishes, sagging skin, or any combination thereof.

[0118] In some aspects, disclosed is a method for preparing the cosmetic products disclosed herein, the method comprising disposing the cosmetic composition into a vessel and at least partially closing the vessel with a closing component.

[0119] Various aspects are contemplated herein, several of which are set forth in the paragraphs below. It is explicitly contemplated that any aspect or portion thereof can be combined to form a combination.

[0120] Aspect 1: A cosmetic product, comprising: a vessel configured to contain a cosmetic composition; and a closing component configured to at least partially close the vessel; wherein the cosmetic composition is disposed within the vessel and comprises: a carrier; and a bioactive glass, comprising:15-55 wt.% SiO2;0.1-15 wt.% ZrO2;20-60 wt.% CaO; and5-30 wt.% P2O5.

[0121] Aspect 2: The cosmetic product of any preceding aspect, wherein the carrier comprises one or more of a skin soothing agent, an emollient, a humectant, a mineral, an antioxidant, a sun filter, or any combination thereof.

[0122] Aspect 3: The cosmetic product of aspect 2, or any preceding aspect, wherein: the skin soothing agent comprises botanic extracts, allantoin, bisabolol, colloidal oatmeal, panthenol, niacinamide, or any combination thereof; the emollient comprises caprylic / capric triglycerides, cetyl alcohol, ceramide, phytosphiosine, squalene, seed oils, botanic extract oils, isohexadecane, isononyl isononanoate, stearalkonium hectorite, galactoarabinan, isoeicosane, hydrogenated polyisobutene, dimethicone, allantoin, niacinamide jojoba oil, shea butter, avocado oil, argan oil, lanolin, petrolatum, mineral oil, isopropyl myristate, stearyl alcohol, myristyl myristate, or any combination thereof; the humectant comprises sodium hyaluronate, saccharide isomerate, glycerin, sodium hyaluronate, sodium lauroyl lactylate, sorbitol, propylene glycol, urea, honey, butylene glycol, polyethylene glycol (PEG), sorbitol, lactic acid, or any combination thereof; the mineral comprises magnesium chloride, calcium chloride, sodium chloride, potassium chloride, zinc chloride, or any combination thereof;the antioxidant comprises vitamin E, provitamin B5, vitamin C, vitamin A, green tea extract, resveratrol, coenzyme Qio, lycopene, or any combination thereof; the sun filter comprises titanium dioxide, zinc oxide, avobenzone, octinoxate, octisalate, oxybenzone, homosalate, or any combination thereof; or any combination thereof.

[0123] Aspect 4: The cosmetic product of any preceding aspect, wherein the carrier comprises one or more of a rheology modifier, a preservative, an emulsifier, a stabilizer, a pigment, a texturizer, a diluent, or any combination thereof.

[0124] Aspect 5: The cosmetic product of aspect 4, or any preceding aspect, wherein: the rheology modifier comprises hydroxypropyl guar, cetyl palmitate, xanthan gum, botanic extract buffers, cetearyl alcohol, polysorbate 60, silica, alumina, PEG-30 dipolyhydroxystearate, wax, caprate, triheptanoin, dilinoleic acid, hydroxyethylcellulose, carbomer, acacia gum, carrageenan, agar, pectin, bentonite, montmorillonite, carboxymethylcellulose (CMC), or any combination thereof; the preservative comprises phenoxyethanol, sorbic acid, caprylyl glycol, 1,2- hexanediol, benzyl alcohol, behentrimonium methosulfate, dehydroacetic acid, ethylhexylglycerin, sodium benzoate, potassium sorbate, methylparaben, ethylparaben, propylparaben, DMDM hydantoin, quatemium-15, or any combination thereof; the emulsifier comprises cetearyl alcohol, cetearyl glucoside, ceteareth-20, behentrimonium methosulfate, behenyl alcohol, polyglyceryl-3 stearate, glyceryl stearate, sodium acrylate, isohexadecane, polysorbate 80, sodium lauroyl lactylate, lecithin, polyglyceryl-4 oleate, olive sedate, PEG-7 glyceryl monococoate, sorbitan stearate, polysorbate 20, polysorbate 40, sucrose laurate, lecithin, sodium stearoyl glutamate, glyceryl oleate citrate, or any combination thereof; the stabilizer comprises sodium gluconate, sodium citrate, potassium citrate, calcium gluconate, magnesium gluconate, or any combination thereof; the pigment comprises iron oxide, mica, titanium dioxide, zinc oxide, ultramarines, chromium oxide greens, ferric ferrocyanide, carmine, or any combination thereof; the texturizer comprises silica, boron nitride, kaolin, talc, magnesium hydroxide, polymethylsilsesquioxane, aluminum starch octenylsuccinate, nylon- 12, silica silylate, com starch, rice starch, zinc orthophosphate, sodium bicarbonate, alumina, calcium carbonate, calcium pyrophosphate, or any combination thereof; the diluent comprises water, glycerin, seed oil, wax, starch, magnesium stearate, octyldodecanol, pearl powder, caprylic / capric triglyceride, squalane, isopropyl palmitate, cyclomethicone, decyl oleate, C12-C15 alkyl benzoate, or any combination thereof; or any combination thereof.

[0125] Aspect 6: The cosmetic product of any preceding aspect, wherein the vessel comprises a bottle, a jar, a tube, a bag, a canister, a pouch, a cartridge, a flask, a vial, a cask, a drum, a barrel, a box, a crate, a keg, a bin, a jug, a pot, a sack, a basket, a bucket, a carton, a package, a tin, or any combination thereof.

[0126] Aspect 7: The cosmetic product of any preceding aspect, wherein the closing component comprises a cap, a lid, a stopper, a cork, a seal, a plug, a cover, a clamp, a zipper, a snap, a lock, a slider, a drawstring, a screw, a buckle, a button, a hook, a clasp, a bung, a spigot, a valve, a lid with a gasket, a flip-top, a twist-off cap, a press-on lid, a roll-on applicator, a pump, a dropper, a sprayer, a dispenser, a heat seal, a pressure seal, a tie, a twist tie, a clip, a band, a cinch, a knot, a self-sealing mechanism, an adhesive strip, a zip lock, a staple, a fold and tuck closure, or any combination thereof.

[0127] Aspect 8: The cosmetic product of any preceding aspect, wherein the cosmetic composition does not contain a detectable amount of an amino acid, as measured by high performance liquid chromatography .

[0128] Aspect 9: The cosmetic product of any preceding aspect, wherein, when the bioactive glass is subjected to a composition at 37 °C and a pH of 6.5 to form a mixture, a total amount of calcium ions in the mixture increases every 2 hours over a 12 hour period, wherein the composition comprises 0.05 wt.% sodium chloride, 0. 1 wt.% urea, 0. 1 wt.% lactic acid, and a balance of water.

[0129] Aspect 10: The cosmetic product of any preceding aspect, wherein the bioactive glass comprises:25-35 wt.% SiO2;35-50 wt.% CaO; and15-25 wt.% P2O5; based on total weight of the bioactive glass.

[0130] Aspect 11: The cosmetic product of any preceding aspect, wherein the bioactive glass comprises:3-12 wt.% ZrO2;0-25 wt.% MgO;0-5 wt.% F";0-5 wt.% Na2O+K2O+Li2O;0-5 wt.% A12O3;0-5 wt.% B2O3;0-5 wt.% Na2O;0-5 wt.% K2O;CaO+P2O5 in an amount of 40-70 wt.%; or any combination thereof; based on total weight of the bioactive glass

[0131] Aspect 12: The cosmetic product of any one of aspects 4-11, or any preceding aspect, wherein the cosmetic composition is a toner, and the carrier comprises: the skin soothing agent, optionally comprising botanic extracts; the mineral, optionally comprising magnesium chloride, calcium chloride, or a combination thereof; the rheology modifier, optionally comprising hydroxypropyl guar; the humectant, optionally comprising sodium hyaluronate, saccharide isomerate, or a combination thereof; the preservative, optionally comprising phenoxyethanol, sorbic acid, caprylyl glycol, or any combination thereof; and the diluent, optionally comprising water.

[0132] Aspect 13: The cosmetic product of any preceding aspect, wherein the cosmetic composition is a lotion, and the carrier comprises: the humectant, optionally comprising glycerin, sodium hyaluronate, sodium lauroyl lactylate, or any combination thereof; the emollient, optionally comprising caprylic / capric triglycerides, cetyl alcohol, ceramide, phytosphiosine, or any combination thereof; the emulsifier, optionally comprising cetearyl alcohol, ceteareth-20, behentrimonium methosulfate, or any combination thereof; the preservative, optionally comprising phenoxyethanol, sorbic acid, caprylyl glycol, or any combination thereof; and the diluent, optionally comprising water.

[0133] Aspect 14: The cosmetic product of any preceding aspect, wherein the cosmetic composition is a moisturizer, and the carrier comprises: the emulsifier, optionally comprising behenyl alcohol, polyglyceryl-3 stearate, glyceryl stearate, cetearyl alcohol, cetearyl glucoside, or any combination thereof; the humectant, optionally comprising glycerin; the emollient, optionally comprising squalene, caprylic / capric triglycerides, ceramide, or any combination thereof; the rheology modifier, optionally comprising cetyl palmitate; the preservative, optionally comprising 1,2-hexanediol, caprylyl glycol, or a combination thereof; the diluent, optionally comprising water.

[0134] Aspect 15: The cosmetic product of any preceding aspect, wherein the cosmetic composition is a serum, and the carrier comprises: the humectant, optionally comprising sodium hyaluronate;the antioxidant, optionally comprising vitamin E, provitamin B5, or a combination thereof; the emollient, optionally comprising squalene, seed oils, caprylic / capric triglycerides, ceramide, or any combination thereof; the rheology modifier, optionally comprising xanthan gum; the stabilizer, optionally comprising sodium gluconate; the preservative, optionally comprising 1,2-hexanediol, caprylyl glycol, or a combination thereof; the skin soothing agent, optionally comprising botanic extracts; and the diluent, optionally comprising water.

[0135] Aspect 16: The cosmetic product of any preceding aspect, wherein the cosmetic composition is a sensitive skin care formulation, and the carrier comprises: the humectant, optionally comprising sorbitol; the emollient, optionally comprising botanic extract oils, caprylic / capric triglycerides, cetyl alcohol, ceramide, or any combination thereof; the rheology modifier, optionally comprising botanic extract buffers, cetearyl alcohol, polysorbate 60, xanthan gum, or any combination thereof; the emulsifier, optionally comprising sodium acrylate, isohexadecane, polysorbate 80, cetearyl glucoside, or any combination thereof; the antioxidant, optionally comprising vitamin E; the preservative, optionally comprising benzyl alcohol; and the diluent, optionally comprising water.

[0136] Aspect 17: The cosmetic product of any preceding aspect, wherein the cosmetic composition is a sunscreen, and the carrier comprising: the sun filter, optionally comprising titanium dioxide, zinc oxide, or a combination thereof; the rheology modifier, optionally comprising silica, alumina, PEG-30 dipolyhydroxystearate, wax, or any combination thereof; the emollient, optionally comprising caprylic / capric triglyceride, isohexadecane, isononyl isononanoate, ceramide, or any combination thereof; the emulsifier, optionally comprising sodium lauroyl lactylate, glyceryl stearate, cetearyl alcohol, cetearyl glucoside, or any combination thereof; the preservative, optionally comprising behentrimonium methosulfate; and the diluent, optionally comprising water.

[0137] Aspect 18: The cosmetic product of any preceding aspect, wherein the cosmetic composition is a lotion primer, and the carrier comprises:the texturizer, optionally comprising silica; the rheology modifier, optionally comprising xanthan gum, caprate, triheptanoin, dilinoleic acid, or any combination thereof; the emollient, optionally comprising caprylic / capric triglyceride, stearalkonium hectorite, galactoarabinan, or any combination thereof; the emulsifier, optionally comprising lecithin, polyglyceryl-4 oleate, olive sedate, or any combination thereof; the antioxidant, optionally comprising vitamin E; the pigment, optionally comprising iron oxide, mica, or a combination thereof; the preservative, optionally comprising benzylalcohol, dehydroacetic acid, or a combination thereof; and the diluent, optionally comprising water.

[0138] Aspect 19: The cosmetic product of any preceding aspect, wherein the cosmetic composition is a gel foundation, and the carrier comprises: the texturizer, optionally comprising silica; the emollient, optionally comprising caprylic / capric triglyceride, isoeicosane, or any combination thereof; the emulsifier, optionally comprising PEG-7 glyceryl monococoate, isohexadecane, polysorbate 80, or any combination thereof; the humectant, optionally comprising glycerin; the antioxidant, optionally comprising vitamin E; the pigment, optionally comprising iron oxide, titanium dioxide, mica, or any combination thereof; the preservative, optionally comprising benzylalcohol, dehydroacetic acid, or a combination thereof; and the diluent, optionally comprising water.

[0139] Aspect 20: The cosmetic product of any preceding aspect, wherein the cosmetic composition is a powder foundation, and the carrier comprises: the texturizer, optionally comprising silica, boron nitride, kaolin, talc, or any combination thereof; the emollient, optionally comprising caprylic / capric triglyceride, hydrogenated polyisobutene, or a combination thereof; the antioxidant, optionally comprising vitamin E; the pigment, optionally comprising iron oxide, titanium dioxide, mica, or any combination thereof; andthe diluent, optionally comprising seed oil, wax, starch, magnesium stearate, or any combination thereof.

[0140] Aspect 21: The cosmetic product of any preceding aspect, wherein the cosmetic composition is a concealer, and the carrier comprises: the texturizer, optionally comprising silica, talc, polymethylsilsesquioxane, dimethicone, or any combination thereof; the emollient, optionally comprising caprylic / capric triglyceride, polyhydroxystearic acid, isododecane, or any combination thereof; the antioxidant, optionally comprising vitamin E; the pigment, optionally comprising iron oxide, titanium dioxide, mica, or any combination thereof; and the diluent, optionally comprising seed oil, octyldodecanol, wax.

[0141] Aspect 22: The cosmetic product of any preceding aspect, wherein the cosmetic composition is a face powder, and the carrier comprises: the texturizer, optionally comprising silica, kaolin, magnesium hydroxide, polymethylsilsesquioxane, or any combination thereof; the emollient, optionally comprising dimethicone, allantoin, niacinamide, or any combination thereof; the pigment, optionally comprising iron oxide, titanium dioxide, mica, or any combination thereof; and the diluent, optionally comprising starch, pearl powder, or a combination thereof.

[0142] Aspect 23: A method for preparing the cosmetic product of any preceding aspect, the method comprising disposing the cosmetic composition into the vessel and at least partially closing the vessel with the closing component.

[0143] Aspect 24: A combination of any two or more of aspects 1-23, or any one or more portions thereof.EXAMPLES

[0144] The following examples illustrate non-limiting aspects of the disclosure and are not intended to be limiting on the scope of the disclosure or claims.

[0145] Example 1 - Calcium Ion Release from Bioactive Glass

[0146] This example demonstrates the continuous release of calcium ions over a 24 hour period in simulated body fluid (artificial sweat).

[0147] Two bioactive glasses were prepared having the compositions shown in Table 2 below using standard processes known in the art (as described elsewhere herein). The comparative composition was prepared to target the 45 S5 Bioglass® sold by Haleon under the Sensodyne® brand featuring NovaMin® technology.Table 2

[0148] Each glass was separately added in an amount of 5 wt.% to a simulated body fluid (artificial sweat) having the following composition: 0.05 wt.% sodium chloride, 0.1 wt.% urea, 0.1 wt.% lactic acid, balance distilled water, in which the composition has been adjusted to pH of 6.5 using acid / base as needed. The mixture of bioactive glass in artificial sweat was heated to 37 °C and the amount of calcium in the mixture measured at intervals over a 24 hour period. Calcium measured in the simulated body fluid prior to addition of the glass was subtracted from the measured amounts during the test to result in the “Ca release” shown in FIG. 1.

[0149] The relative calcium concentration is about 2-5 times of that from 45S5, where the ladder displays diminished calcium concentrations over time. Calcium serves as nutrient for cell proliferation and differentiation. Therefore, a higher calcium release rate is believed to be beneficial for cell regenerative performance.

[0150] Introduction to Examples 2-11 - Example Cosmetic Compositions

[0151] Exemplified potential cosmetic compositions of the cosmetic products utilizing the bioactive glasses disclosed herein are illustrated in these examples and elsewhere throughout this disclosure. The bioactive glasses of the disclosure possesses excellent water resistance, which is suitable for use in both aqueous based skincare products (e.g., 0.5-2 wt.% bioactive glass) and nonaqueous based cosmetics (e.g., 3-15 wt.% bioactive glass). The bioactive glass particles can directly admix or replace certain portions of the rheology modifier, such as silica up to 15 wt.% in total in the cosmetic composition. The bioactive glasses not only can serve as a rheology modifier, but also provides steady release of ions, such as calcium, magnesium, phosphate, silicon / silicate, or any combination thereof, to promote cell proliferation, growth, wound healing, anti-inflammation, or any combination thereof. It is believed that the bioactive glasses herein, when blended in the cosmetic compositions of the cosmetic products, can achieve various beneficial properties, such as anti-aging, through release of calcium, magnesium, phosphate, and / or silicon / silicate ions.

[0152] Example 2 - Toners

[0153] Beneficial elements of proposed formulations of facial toners are moisturizers from various electrolytes, soothing extracts, vitamins, and minerals. Here, bioactive glasses of the disclosure can be added to at least partially replace the minerals and / or electrolytes in the toner formulations. The bioactive glasses herein not only serve as a replacement of minerals and / or preservatives (antimicrobials), but also maintain skin cells, such as keratinocytes, in isotonic status. A potential formulation for a cosmetic composition that is a toner is shown below in Table 3. This cosmetic composition is considered an aqueous based cosmetic composition.Table 3. Proposed Cosmetic Composition for a Toner

[0154] Example 3 - Lotions

[0155] Beneficial elements of proposed formulations of lotions are moisturizers such as humectants and emollients, including glycerin and / or natural oils. Here, the disclosed BAGs can be added to at least partially replace the emollients and / or antimicrobials since the sodium ion from BAGs could inhibit bacteria growth. BAGs not only serve as a replacement of emollient or preservatives (antimicrobials), but also may promote the growth of skin cells, such as keratinocytes, to alleviate dry skin. A potential formulation for a cosmetic composition that is a lotion is shown below in Table 4. This cosmetic composition is considered an aqueous based cosmetic composition.Table 4. Proposed Cosmetic Composition for a Lotion

[0156] Example 4 - Moisturizers

[0157] Beneficial elements of proposed formulations of moisturizers are moisturizers and emollients, such as cetearyl glucoside, glycerin, natural buffers, or any combination thereof. Here, the disclosed BAGs can be added to at least partially replace the rheology modifiers or antimicrobials. BAGs not only serve as a replacement of stabilizers, rheology modifiers, or preservatives (antimicrobials), but also promote growth of skin cells, such as keratinocytes, to maintain the skin in a hydrated state. A potential formulation for a cosmetic composition that is a moisturizer is shown below in Table 5. This cosmetic composition is considered an aqueous based cosmetic composition.Table 5. Proposed Cosmetic Composition for a Moisturizer

[0158] Example 5 - Serums

[0159] Beneficial elements of proposed formulations of serum are moisturizers and antioxidants to soothe and improve skin hydration and regeneration. Here, the disclosed BAGs can be added to at least partially replace the rheology modifier and / or antioxidant. BAGs not only serve as a replacement of antioxidants, but also promote growth of skin cells, such as keratinocytes, to improve skin health. A potential formulation for a cosmetic composition that is a serum is shown below in Table 6. This cosmetic composition is considered an aqueous based cosmetic composition.Table 6. Proposed Cosmetic Composition for a Serum

[0160] Example 6 - Sensitive Skin Care Formulation

[0161] Beneficial elements of proposed formulations of sensitive skin care formulations are emollients and mild preservatives to soothe and reinforce the skin’s natural barrier. Here, the disclosed BAGs can be added to at least partially replace the emollients or antimicrobials. BAGs not only serve as a replacement of emollients and / or antimicrobial agents, but also empower skin cells, such as keratinocytes, with strengthened barriers by promoting cell proliferation. A potential formulation for a cosmetic composition that is a sensitive skin care formulation is shown below in Table 7. This cosmetic composition is considered an aqueous based cosmetic composition.Table 7. Proposed Cosmetic Composition for a Sensitive Skin Care Formulation

[0162] Example 7 -Sunscreen

[0163] Beneficial elements of proposed formulations of sunscreens (such as physical sunscreens) or tint moisturizers are sun filters, such as titanium oxide and zinc oxide. Here, the disclosed BAGs can be added to at least partially replace the rheology modifiers, since both share silica as a main component. BAGs not only serve as a replacement of rheology modifiers, but also maintain the health of skin cells, such as keratinocytes, in a hydrated state, and soothes the sticky texture of sunscreens. In addition, the formulation of physical sunscreens can be further extended to tinted moisturizer which the main components are similar but with higher ratio of a pigment. A potential formulation for a cosmetic composition that is a sunscreen is shown below in Table 8. This cosmetic composition is considered a non-aqueous based cosmetic composition.Table 8. Proposed Cosmetic Composition for a Sunscreen

[0164] Example 8 - Lotion Primer

[0165] Beneficial elements of proposed formulations of lotion primer are moisturizers and texturizers, in which both moisturization and skin appearance are equally desired. Here, the disclosed BAGs can be added to at least partially replace the texturizer since both share the silica as a main component. BAGs not only serve as a replacement of texturizers, but also supplies stimulators for renewal of skin cells, such as keratinocytes, in which transepidermal water loss reduction and steady ion releasing could sooth skin and decrease appearance of superficial fine lines. In addition, adjustable BAG particle size to a few micrometers or submicron could further enhance emulsion uniformity, promote stability, and / or enhance the glaze look by the microcrystalline hydroxyapatite that can crystallize from or on the BAG. A potential formulation for a cosmetic composition that is a lotion primer is shown below in Table 9. This cosmetic composition is considered a non-aqueous based cosmetic composition.Table 9. Proposed Cosmetic Composition for a Lotion Primer

[0166] Example 9 - Gel Foundation & Powder Foundation

[0167] Beneficial elements of proposed formulations of gel foundation are texturizer, such as silica, mica or kaolin. Here, the disclosed BAGs can be added to at least partially replace the texturizer since both share the silica as a main component. BAGs not only serve as a replacement of texturizer, but also enhance the health of skin cells, such as keratinocytes, by steadily releasing ions.In addition, adjusting BAG particle sizes to a few micrometers or submicron could also give soft feeling and easy for spreading for gel foundations. Furthermore, the formulation of gle foundation can be further extended to powder foundation, in which the main components are similar, but the seed oil is replaced with solid fillers, such as rice starch, magnesium stearate, and so forth. Potential formulations for cosmetic compositions that are a foundation are shown below in Table 10 (gel foundation) and Table 11 (powder foundation). These cosmetic compositions are considered a nonaqueous based cosmetic compositions.Table 10. Proposed Cosmetic Composition for a Gel FoundationTable 11. Proposed Cosmetic Composition for a Powder Foundation

[0168] Example 10 - Concealer

[0169] Beneficial elements of proposed formulations of concealer are pigments and texturizers, which concealer is typically in a light mousse texture. Here, the disclosed BAGs can be added to at least partially replace the texturizers since both share the silica as a main component. BAGs not only serve as a replacement of texturizer, but also enhances the glaze look by the microcrystalline hydroxyapatite transformed from BAG. In addition, adjustable BAG particle sizes to a few micrometers or submicron could also give a velvet feeling. A potential formulation for a cosmetic composition that is a concealer is shown below in Table 12. This cosmetic composition is considered a non-aqueous based cosmetic composition.Table 12. Proposed Cosmetic Composition for a Concealer

[0170] Example 11 - Face Powder

[0171] Beneficial elements of proposed formulations of face powder are pigment and texturizer in powder format. Here, the disclosed BAGs can be added to at least partially replace the texturizer since both share the silica as a main component. BAGs not only serve as a replacement of texturizer, but they also absorb excess oils owing to its porous structure while also transforming to hydroxyapatite. In addition, adjustable BAG particle sizes to a few micrometers or submicron could also lead to diminished wrinkles and providing a light glow. A potential formulation for a cosmetic composition that is a face powder is shown below in Table 13. This cosmetic composition is considered a nonaqueous based cosmetic composition.Table 13. Proposed Cosmetic Composition for a Face Powder

[0172] As used herein, the term “and / or,” when used in a list of two or more items, means that any one of the listed items can be employed by itself, or any combination of two or more of the listed items can be employed. For example, if a composition is described as containing components A, B, and / or C, the composition can contain A alone; B alone; C alone; A and B in combination; A and C in combination; B and C in combination; or A, B, and C in combination.

[0173] References herein to the positions of elements (e.g., “top,” “bottom,” “above,” “below,” “first,” “second,” etc.) are merely used to describe the orientation of various elements in the FIGURES. It should be noted that the orientation of various elements may differ according to other exemplary embodiments, and that such variations are intended to be encompassed by the present disclosure. Moreover, these relational terms are used solely to distinguish one entity or action fromanother entity or action, without necessarily requiring or implying any actual such relationship or order between such entities or actions.

[0174] Modifications of the disclosure will occur to those skilled in the art and to those who make or use the disclosure. Therefore, it is understood that the embodiments shown in the drawings and described above are merely for illustrative purposes and not intended to limit the scope of the disclosure, which is defined by the following claims, as interpreted according to the principles of patent law, including the doctrine of equivalents.

[0175] It will be understood by one having ordinary skill in the art that construction of the described disclosure, and other components, is not limited to any specific material. Other exemplary embodiments of the disclosure disclosed herein may be formed from a wide variety of materials, unless described otherwise herein.

[0176] As utilized herein, the terms “approximately,” “about,” “substantially”, and similar terms are intended to have a broad meaning in harmony with the common and accepted usage by those of ordinary skill in the art to which the subject matter of this disclosure pertains. It should be understood by those of skill in the art who review this disclosure that these terms are intended to allow a description of certain features described and claimed without restricting the scope of these features to the precise numerical ranges provided. Accordingly, these terms should be interpreted as indicating that insubstantial or inconsequential modifications or alterations of the subject matter described and claimed are considered to be within the scope of the invention as recited in the appended claims.

[0177] As utilized herein, “optional,” “optionally,” or the like are intended to mean that the subsequently described event or circumstance can or cannot occur, and that the description includes instances where the event or circumstance occurs and instances where it does not occur. As used herein, the indefinite articles “a,” “an,” and the corresponding definite article “the” mean “at least one” or “one or more,” unless otherwise specified. It also is understood that the various features disclosed in the specification and the drawings can be used in any and all combinations.

[0178] With respect to the use of substantially any plural and / or singular terms herein, those having skill in the art can translate from the plural to the singular and / or from the singular to the plural as is appropriate to the context and / or application. The various singular / plural permutations may be expressly set forth herein for the sake of clarity.

[0179] Unless otherwise specified, all compositions are expressed in terms of as-batched weight percent (wt.%). As will be understood by those having ordinary skill in the art, various melt constituents (e.g., silicon, alkali- or alkaline-based, boron, etc.) may be subject to different levels of volatilization (e.g., as a function of vapor pressure, melt time and / or melt temperature) during melting of the constituents. As such, the as-batched weight percent values used in relation to such constituents are intended to encompass values within ±0.5 wt.% of these constituents in final, as-melted articles.With the forgoing in mind, substantial compositional equivalence between final articles and as- batched compositions is expected.

[0180] It will be apparent to those skilled in the art that various modifications and variations can be made without departing from the spirit or scope of the claimed subject matter. Accordingly, the claimed subject matter is not to be restricted except in light of the attached claims and their equivalents.

Claims

WHAT IS CLAIMED IS:

1. A cosmetic product, comprising: a vessel configured to contain a cosmetic composition; and a closing component configured to at least partially close the vessel; wherein the cosmetic composition is disposed within the vessel and comprises: a carrier; and a bioactive glass, comprising:15-55 wt.% SiO2;0.1-15 wt.% ZrO2;20-60 wt.% CaO; and5-30 wt.% P2O5.

2. The cosmetic product of any preceding claim, wherein the carrier comprises one or more of a skin soothing agent, an emollient, a humectant, a mineral, an antioxidant, a sun filter, or any combination thereof.

3. The cosmetic product of claim 2, wherein: the skin soothing agent comprises botanic extracts, allantoin, bisabolol, colloidal oatmeal, panthenol, niacinamide, or any combination thereof; the emollient comprises caprylic / capric triglycerides, cetyl alcohol, ceramide, phytosphiosine, squalene, seed oils, botanic extract oils, isohexadecane, isononyl isononanoate, stearalkonium hectorite, galactoarabinan, isoeicosane, hydrogenated polyisobutene, dimethicone, allantoin, niacinamide jojoba oil, shea butter, avocado oil, argan oil, lanolin, petrolatum, mineral oil, isopropyl myristate, stearyl alcohol, myristyl myristate, or any combination thereof; the humectant comprises sodium hyaluronate, saccharide isomerate, glycerin, sodium hyaluronate, sodium lauroyl lactylate, sorbitol, propylene glycol, urea, honey, butylene glycol, polyethylene glycol (PEG), sorbitol, lactic acid, or any combination thereof; the mineral comprises magnesium chloride, calcium chloride, sodium chloride, potassium chloride, zinc chloride, or any combination thereof; the antioxidant comprises vitamin E, provitamin B5, vitamin C, vitamin A, green tea extract, resveratrol, coenzyme Qio, lycopene, or any combination thereof; the sun filter comprises titanium dioxide, zinc oxide, avobenzone, octinoxate, octisalate, oxybenzone, homosalate, or any combination thereof; or any combination thereof.

4. The cosmetic product of any preceding claim, wherein the carrier comprises one or more of a rheology modifier, a preservative, an emulsifier, a stabilizer, a pigment, a texturizer, a diluent, or any combination thereof.

5. The cosmetic product of claim 4, wherein: the rheology modifier comprises hydroxypropyl guar, cetyl palmitate, xanthan gum, botanic extract buffers, cetearyl alcohol, polysorbate 60, silica, alumina, PEG-30 dipolyhydroxystearate, wax, caprate, triheptanoin, dilinoleic acid, hydroxyethylcellulose, carbomer, acacia gum, carrageenan, agar, pectin, bentonite, montmorillonite, carboxymethylcellulose (CMC), or any combination thereof; the preservative comprises phenoxyethanol, sorbic acid, caprylyl glycol, 1,2- hexanediol, benzyl alcohol, behentrimonium methosulfate, dehydroacetic acid, ethylhexylglycerin, sodium benzoate, potassium sorbate, methylparaben, ethylparaben, propylparaben, DMDM hydantoin, quatemium-15, or any combination thereof; the emulsifier comprises cetearyl alcohol, cetearyl glucoside, ceteareth-20, behentrimonium methosulfate, behenyl alcohol, polyglyceryl-3 stearate, glyceryl stearate, sodium acrylate, isohexadecane, polysorbate 80, sodium lauroyl lactylate, lecithin, polyglyceryl-4 oleate, olive sedate, PEG-7 glyceryl monococoate, sorbitan stearate, polysorbate 20, polysorbate 40, sucrose laurate, lecithin, sodium stearoyl glutamate, glyceryl oleate citrate, or any combination thereof; the stabilizer comprises sodium gluconate, sodium citrate, potassium citrate, calcium gluconate, magnesium gluconate, or any combination thereof; the pigment comprises iron oxide, mica, titanium dioxide, zinc oxide, ultramarines, chromium oxide greens, ferric ferrocyanide, carmine, or any combination thereof; the texturizer comprises silica, boron nitride, kaolin, talc, magnesium hydroxide, polymethylsilsesquioxane, aluminum starch octenylsuccinate, nylon- 12, silica silylate, com starch, rice starch, zinc orthophosphate, sodium bicarbonate, alumina, calcium carbonate, calcium pyrophosphate, or any combination thereof; the diluent comprises water, glycerin, seed oil, wax, starch, magnesium stearate, octyldodecanol, pearl powder, caprylic / capric triglyceride, squalane, isopropyl palmitate, cyclomethicone, decyl oleate, C12-C15 alkyl benzoate, or any combination thereof; or any combination thereof.

6. The cosmetic product of any preceding claim, wherein the vessel comprises a bottle, a jar, a tube, a bag, a canister, a pouch, a cartridge, a flask, a vial, a cask, a drum, a barrel, a box, a crate, a keg, a bin, a jug, a pot, a sack, a basket, a bucket, a carton, a package, a tin, or any combination thereof.

7. The cosmetic product of any preceding claim, wherein the closing component comprises a cap, a lid, a stopper, a cork, a seal, a plug, a cover, a clamp, a zipper, a snap, a lock, a slider, a drawstring, a screw, a buckle, a button, a hook, a clasp, a bung, a spigot, a valve, a lid with a gasket, a flip-top, a twist-off cap, a press-on lid, a roll-on applicator, a pump, a dropper, a sprayer, a dispenser, a heat seal, a pressure seal, a tie, a twist tie, a clip, a band, a cinch, a knot, a self-sealing mechanism, an adhesive strip, a zip lock, a staple, a fold and tuck closure, or any combination thereof.

8. The cosmetic product of any preceding claim, wherein the cosmetic composition does not contain a detectable amount of an amino acid, as measured by high performance liquid chromatography .

9. The cosmetic product of any preceding claim, wherein, when the bioactive glass is subjected to a composition at 37 °C and a pH of 6.5 to form a mixture, a total amount of calcium ions in the mixture increases every 2 hours over a 12 hour period, wherein the composition comprises 0.05 wt.% sodium chloride, 0.1 wt.% urea, 0.1 wt.% lactic acid, and a balance of water.

10. The cosmetic product of any preceding claim, wherein the bioactive glass comprises:25-35 wt.% SiO2;35-50 wt.% CaO; and15-25 wt.% P2O5; based on total weight of the bioactive glass.

11. The cosmetic product of any preceding claim, wherein the bioactive glass comprises:3-12 wt.% ZrO2;0-25 wt.% MgO;0-5 wt.% F";0-5 wt.% Na2O+K2O+Li2O;0-5 wt.% A12O3;0-5 wt.% B2O3;0-5 wt.% Na2O;0-5 wt.% K2O;CaO+P2O5 in an amount of 40-70 wt.%; or any combination thereof; based on total weight of the bioactive glass12. The cosmetic product of any one of claims 4-11, wherein the cosmetic composition is a toner, and the carrier comprises: the skin soothing agent, optionally comprising botanic extracts;the mineral, optionally comprising magnesium chloride, calcium chloride, or a combination thereof; the rheology modifier, optionally comprising hydroxypropyl guar; the humectant, optionally comprising sodium hyaluronate, saccharide isomerate, or a combination thereof; the preservative, optionally comprising phenoxyethanol, sorbic acid, caprylyl glycol, or any combination thereof; and the diluent, optionally comprising water.

13. The cosmetic product of any preceding claim, wherein the cosmetic composition is a lotion, and the carrier comprises: the humectant, optionally comprising glycerin, sodium hyaluronate, sodium lauroyl lactylate, or any combination thereof; the emollient, optionally comprising caprylic / capric triglycerides, cetyl alcohol, ceramide, phytosphiosine, or any combination thereof; the emulsifier, optionally comprising cetearyl alcohol, ceteareth-20, behentrimonium methosulfate, or any combination thereof; the preservative, optionally comprising phenoxyethanol, sorbic acid, caprylyl glycol, or any combination thereof; and the diluent, optionally comprising water.

14. The cosmetic product of any preceding claim, wherein the cosmetic composition is a moisturizer, and the carrier comprises: the emulsifier, optionally comprising behenyl alcohol, polyglyceryl-3 stearate, glyceryl stearate, cetearyl alcohol, cetearyl glucoside, or any combination thereof; the humectant, optionally comprising glycerin; the emollient, optionally comprising squalene, caprylic / capric triglycerides, ceramide, or any combination thereof; the rheology modifier, optionally comprising cetyl palmitate; the preservative, optionally comprising 1,2-hexanediol, caprylyl glycol, or a combination thereof; the diluent, optionally comprising water.

15. The cosmetic product of any preceding claim, wherein the cosmetic composition is a serum, and the carrier comprises: the humectant, optionally comprising sodium hyaluronate; the antioxidant, optionally comprising vitamin E, provitamin B5, or a combination thereof;the emollient, optionally comprising squalene, seed oils, caprylic / capric triglycerides, ceramide, or any combination thereof; the rheology modifier, optionally comprising xanthan gum; the stabilizer, optionally comprising sodium gluconate; the preservative, optionally comprising 1,2-hexanediol, caprylyl glycol, or a combination thereof; the skin soothing agent, optionally comprising botanic extracts; and the diluent, optionally comprising water.

16. The cosmetic product of any preceding claim, wherein the cosmetic composition is a sensitive skin care formulation, and the carrier comprises: the humectant, optionally comprising sorbitol; the emollient, optionally comprising botanic extract oils, caprylic / capric triglycerides, cetyl alcohol, ceramide, or any combination thereof; the rheology modifier, optionally comprising botanic extract buffers, cetearyl alcohol, polysorbate 60, xanthan gum, or any combination thereof; the emulsifier, optionally comprising sodium acrylate, isohexadecane, polysorbate 80, cetearyl glucoside, or any combination thereof; the antioxidant, optionally comprising vitamin E; the preservative, optionally comprising benzyl alcohol; and the diluent, optionally comprising water.

17. The cosmetic product of any preceding claim, wherein the cosmetic composition is a sunscreen, and the carrier comprising: the sun filter, optionally comprising titanium dioxide, zinc oxide, or a combination thereof; the rheology modifier, optionally comprising silica, alumina, PEG-30 dipolyhydroxystearate, wax, or any combination thereof; the emollient, optionally comprising caprylic / capric triglyceride, isohexadecane, isononyl isononanoate, ceramide, or any combination thereof; the emulsifier, optionally comprising sodium lauroyl lactylate, glyceryl stearate, cetearyl alcohol, cetearyl glucoside, or any combination thereof; the preservative, optionally comprising behentrimonium methosulfate; and the diluent, optionally comprising water.

18. The cosmetic product of any preceding claim, wherein the cosmetic composition is a lotion primer, and the carrier comprises: the texturizer, optionally comprising silica;the rheology modifier, optionally comprising xanthan gum, caprate, triheptanoin, dilinoleic acid, or any combination thereof; the emollient, optionally comprising caprylic / capric triglyceride, stearalkonium hectorite, galactoarabinan, or any combination thereof; the emulsifier, optionally comprising lecithin, polyglyceryl-4 oleate, olive sedate, or any combination thereof; the antioxidant, optionally comprising vitamin E; the pigment, optionally comprising iron oxide, mica, or a combination thereof; the preservative, optionally comprising benzylalcohol, dehydroacetic acid, or a combination thereof; and the diluent, optionally comprising water.

19. The cosmetic product of any preceding claim, wherein the cosmetic composition is a gel foundation, and the carrier comprises: the texturizer, optionally comprising silica; the emollient, optionally comprising caprylic / capric triglyceride, isoeicosane, or any combination thereof; the emulsifier, optionally comprising PEG-7 glyceryl monococoate, isohexadecane, polysorbate 80, or any combination thereof; the humectant, optionally comprising glycerin; the antioxidant, optionally comprising vitamin E; the pigment, optionally comprising iron oxide, titanium dioxide, mica, or any combination thereof; the preservative, optionally comprising benzylalcohol, dehydroacetic acid, or a combination thereof; and the diluent, optionally comprising water.

20. The cosmetic product of any preceding claim, wherein the cosmetic composition is a powder foundation, and the carrier comprises: the texturizer, optionally comprising silica, boron nitride, kaolin, talc, or any combination thereof; the emollient, optionally comprising caprylic / capric triglyceride, hydrogenated polyisobutene, or a combination thereof; the antioxidant, optionally comprising vitamin E; the pigment, optionally comprising iron oxide, titanium dioxide, mica, or any combination thereof; andthe diluent, optionally comprising seed oil, wax, starch, magnesium stearate, or any combination thereof.

21. The cosmetic product of any preceding claim, wherein the cosmetic composition is a concealer, and the carrier comprises: the texturizer, optionally comprising silica, talc, polymethylsilsesquioxane, dimethicone, or any combination thereof; the emollient, optionally comprising caprylic / capric triglyceride, polyhydroxystearic acid, isododecane, or any combination thereof; the antioxidant, optionally comprising vitamin E; the pigment, optionally comprising iron oxide, titanium dioxide, mica, or any combination thereof; and the diluent, optionally comprising seed oil, octyldodecanol, wax.

22. The cosmetic product of any preceding claim, wherein the cosmetic composition is a face powder, and the carrier comprises: the texturizer, optionally comprising silica, kaolin, magnesium hydroxide, polymethylsilsesquioxane, or any combination thereof; the emollient, optionally comprising dimethicone, allantoin, niacinamide, or any combination thereof; the pigment, optionally comprising iron oxide, titanium dioxide, mica, or any combination thereof; and the diluent, optionally comprising starch, pearl powder, or a combination thereof.

23. A method for preparing the cosmetic product of any preceding claim, the method comprising disposing the cosmetic composition into the vessel and at least partially closing the vessel with the closing component.

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