Detection chip and detection apparatus

Abstract

A detection chip (10) and a detection apparatus (100). The detection chip (10) comprises a main control module (110) and a plurality of detection modules (120), wherein the main control module (110) is connected to the plurality of detection modules (120) and is used for connecting to a terminal (200) to receive a detection instruction from the terminal (200), and providing a detection voltage of at least one gear to each of the plurality of detection modules (120) under the action of the detection instruction; each detection module (120) performs detection on a biomarker under the driving action of a detection voltage of a target gear, so as to output a detection signal; biomarkers detected by the detection modules (120) are not completely the same, and the target gears of the detection voltages received by the detection modules (120) correspond to the respective biomarkers; and the main control module (110) is further used for transmitting the detection signals to the terminal (200). It can be seen therefrom that a plurality of detection modules (120) are integrated in a detection chip (10), such that on the basis of a detection instruction of a terminal (200), the plurality of detection modules (120) can be respectively controlled to perform detection on biomarkers under the driving of detection voltages of target gears, so as to perform detection on various types of biomarkers at the same time, thereby improving the detection efficiency.

Description

Detection chip and detection device TECHNICAL FIELD

[0001] The present application relates to the technical field of biological detection, in particular to a detection chip and a detection device. BACKGROUND

[0002] The detection chip belongs to the technical field of biological detection, and relates to integrated circuit design, biosensing technology and biological molecule detection. The technology is mainly used in medical diagnosis, environmental monitoring, food safety detection and the like, and realizes rapid and sensitive detection of multiple parameters by integrating multiple detection functions on a single chip. Traditional single detection methods often take a long time, resulting in low detection efficiency. SUMMARY

[0003] Therefore, it is necessary to provide a detection chip and a detection device to solve the above technical problems.

[0004] In a first aspect, the present application provides a detection chip, which comprises a master control module and a plurality of detection modules; the master control module is connected with the plurality of detection modules, and is used for connecting a terminal to receive a detection instruction from the terminal, and providing a detection voltage of at least one gear to the plurality of detection modules under the action of the detection instruction; each detection module detects a biological marker under the driving action of the detection voltage of a target gear to output a detection signal; the biological markers detected by each detection module are not completely the same, and the target gear of the detection voltage received by each detection module corresponds to the biological marker; each detection module comprises a field effect transistor sensor, a biological molecule probe is arranged in the gate of the field effect transistor sensor, and the biological molecule probe is used for specific binding with a target detection object in the biological marker, so that the field effect transistor sensor outputs the detection signal under the driving action of the detection voltage of the target gear.

[0005] The master control module is further used for transmitting the detection signal to the terminal.

[0006] In one of the embodiments, the master module comprises a driving unit, a sampling unit, a communication unit and a control unit; the driving unit is connected with the control unit and N detection modules respectively; the sampling unit is connected with the control unit and the detection modules respectively, used for collecting the detection signals and transmitting the detection signals to the control unit; the communication unit is connected with the control unit, used for communicating with the terminal to transmit the detection instructions to the control unit; the control unit is used for controlling the driving unit to output the detection voltage to at least one of the detection modules according to the detection instructions, and transmitting the detection signals to the communication unit, so that the communication unit transmits the detection signals to the terminal.

[0007] In one of the embodiments, the driving unit comprises a digital-to-analog converter, used for converting a digital electrical signal output by the control unit according to the detection instructions into an analog electrical signal of the detection voltage of the target gear, so that the detection module detects the biomarker under the driving action of the detection voltage of the analog electrical signal.

[0008] In one of the embodiments, the sampling unit comprises an analog-to-digital converter, used for converting the detection signals in the form of digital electrical signals into the form of analog electrical signals and transmitting to the control unit.

[0009] In one of the embodiments, the communication unit comprises a serial communication component or a Bluetooth component.

[0010] In one of the embodiments, the detection voltage is-1V~1V.

[0011] In one of the embodiments, each of the detection modules comprises a field effect transistor sensor, a biomolecule probe is arranged in the gate of the field effect transistor sensor, the biomolecule probe is used for specifically combining with a target detection object in the biomarker, so that the field effect transistor sensor outputs the detection signal under the driving action of the detection voltage of the target gear;

[0012] In one of the embodiments, the field effect transistor includes one of a metal oxide FET, a silicon FET, a graphene FET and a transition metal dichalcogenide FET.

[0013] In one of the embodiments, the biomolecule probe includes one of an antibody, an enzyme, an organic small molecule, a single-stranded DNA, a double-stranded DNA, a two-dimensional DNA nanostructure and a three-dimensional DNA nanostructure.

[0014] In one of the embodiments, the detection chip further comprises a metal packaging structure, the metal packaging structure is used for packaging the master module and the detection modules.

[0015] In a second aspect, the present application also provides a detection device, comprising:

[0016] a terminal;

[0017] a detection chip as described above, in communication connection with the terminal.

[0018] The detection chip and the detection device as described above, the detection chip comprising a master control module and a plurality of detection modules; the master control module is connected with the plurality of detection modules, used for connecting the terminal to receive a detection instruction from the terminal, and providing at least one detection voltage of a target gear to the plurality of detection modules under the action of the detection instruction; each detection module detects a biomarker under the driving action of the detection voltage of the target gear to output a detection signal; the biomarkers detected by each detection module are not completely the same, and the target gear of the detection voltage received by each detection module corresponds to the biomarker; the master control module is also used for transmitting the detection signal to the terminal. It can be seen that the detection chip of the present application integrates a plurality of detection modules, can control the plurality of detection modules to detect the biomarker under the detection voltage of the target gear under the detection instruction of the terminal, can detect a plurality of biomarkers at the same time, and improves the detection efficiency. BRIEF DESCRIPTION OF DRAWINGS

[0019] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the related art, the drawings needed to be used in the description of the embodiments of the present application or the related art will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the present application, and for those skilled in the art, other related drawings can also be obtained without creative labor.

[0020] FIG. 1 is a structural schematic diagram of a detection chip in an embodiment of the present application;

[0021] FIG. 2 is a structural schematic diagram of a master control module in an embodiment of the present application;

[0022] FIG. 3 is a structural schematic diagram of a field effect transistor sensor in an embodiment of the present application;

[0023] FIG. 4 is a structural schematic diagram of a detection chip in an embodiment of the present application;

[0024] FIG. 5 is a structural schematic diagram of a digital-to-analog converter in an embodiment of the present application;

[0025] FIG. 6 is a structural schematic diagram of an analog-to-digital converter in an embodiment of the present application;

[0026] FIG. 7 is a structural schematic diagram of an integrated chip integrated with a Bluetooth component and a CPU in an embodiment of the present application;

[0027] FIG. 8 is a structural schematic diagram of a detection device according to an embodiment of the present application.

[0028] BRIEF DESCRIPTION OF THE DRAWINGS 10: detection device; 100: detection chip; 110: main control module; 111: driving unit; 1111: digital-to-analog converter; 112: sampling unit; 1121: analog-to-digital converter; 113: communication unit; 1131: Bluetooth component; 114: control unit; 1141: CPU; 120: detection module; 121: field effect transistor sensor; 310: substrate; 320: semiconductor layer; 330: channel layer; 340: source; 350: dielectric layer; 360: drain; 370: gate; 380: biomolecular probe; 200: terminal. DETAILED DESCRIPTION

[0029] In order to make the above objectives, features and advantages of the present application more apparent, specific embodiments of the present application will be described in detail below with reference to the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present application. However, the present application can be practiced in a number of different ways beyond the specific embodiments described and it is to be understood that the present application is not limited to the specific embodiments described below.

[0030] In the description of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the purpose of facilitating the description of the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation of the present application.

[0031] In addition, the terms "first", "second", "third" and the like are used only for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the technical features indicated. Therefore, the features defined with "first", "second" can explicitly or implicitly include at least one of the features. In the description of the present application, the meaning of "a plurality of" is at least two, for example, two, three, etc., unless otherwise explicitly and specifically limited.

[0032] In the present application, unless specifically defined and limited otherwise, the terms "mounting", "connected", "connection", "fixed", and the like, should be interpreted broadly, for example, can be fixed connection, can also be detachable connection, or integrated; can be mechanical connection, can also be electrical connection; can be directly connected, can also be indirectly connected through an intermediate medium, can be the internal communication of two elements or the interaction relationship of two elements, unless otherwise specifically limited. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0033] In the present application, unless specifically defined and limited otherwise, the first feature is "on" or "under" the second feature. The first and second features can be in direct contact, or the first and second features can be indirectly in contact through an intermediate medium. Moreover, the first feature "above", "above" and "above" the second feature can be the first feature directly above or obliquely above the second feature, or only indicates that the horizontal height of the first feature is higher than that of the second feature. The first feature "below", "below" and "below" the second feature can be the first feature directly below or obliquely below the second feature, or only indicates that the horizontal height of the first feature is less than that of the second feature.

[0034] It should be noted that when an element is referred to as "fixed to" or "provided on" another element, it can be directly on another element or there can be a middle element. When an element is considered to be "connected" to another element, it can be directly connected to another element or there can be a middle element. The terms "vertical", "horizontal", "up", "down", "left", "right" and similar expressions used herein are for illustrative purposes only and are not the only implementation.

[0035] In one embodiment, referring to FIG. 1, FIG. 1 shows one of the structural schematic diagrams of the detection chip 100 in the present application. The detection chip 100 in the present embodiment includes a master control module 110 and a plurality of detection modules 120 (n detection modules 120 are shown in FIG. 1, n is a positive integer); the master control module 110 is connected with the plurality of detection modules 120, used for connecting a terminal 200 to receive a detection instruction from the terminal 200, and under the action of the detection instruction, providing at least one gear detection voltage to the plurality of detection modules 120; each detection module 120 detects a biological marker under the driving action of the target gear detection voltage to output a detection signal; the biological markers detected by each detection module 120 are not completely the same, and the target gear of the detection voltage received by each detection module 120 corresponds to the biological marker; the master control module 110 is also used for transmitting the detection signal to the terminal 200.

[0036] The main control module 110 refers to a computer chip with signal transmission and signal processing functions, and can be an MCU (Microcontroller Unit). The main control module 110 in the embodiment can form a signal transmission channel with the terminal 200 and the plurality of detection modules 120, respectively, for receiving a detection instruction of the terminal 200, and controlling the plurality of detection modules 120 to detect the biomarker according to the detection instruction, respectively or simultaneously. Specifically, the main control module 110 can provide a detection voltage of a target gear to each detection module 120, and the detection voltage of the target gear corresponds to the biomarker, so that the biomarker can be accurately and efficiently detected. In addition, the main control module 110 can also collect detection signals of the plurality of detection modules 120 in real time, and transmit the detection signals to the terminal 200 after conversion, amplification, filtering and other processing, so that the terminal 200 can analyze the received detection signals to obtain a corresponding detection result.

[0037] It can be understood that the detection voltages of different gears are different in size, and the type of the biomarker to be detected can be determined. In actual application, the user can input a detection instruction including biomarker type information to be detected to the main control module 110 through the terminal 200, so that the main control module 110 provides a detection voltage of a corresponding gear (i.e., a target gear) to the corresponding detection module 120 according to a preset control logic, and realizes detection of the biomarker to be detected. In addition, the terminal 200 can also prestore the corresponding relationship between the detection voltage of the target gear and the biomarker type. When the user inputs the biomarker type to be detected, the terminal 200 can transmit the detection voltage of the corresponding target gear as a detection instruction (i.e., the information carried by the detection instruction is the detection voltage of the target gear) to the main control module 110 based on the biomarker type to be detected, so that the main control module 110 provides a detection voltage of a corresponding gear (i.e., a target gear) to the corresponding detection module 120, and realizes detection of the biomarker to be detected.

[0038] The plurality of detection modules 120 can work independently or cooperatively, and the main control module 110 can provide a target gear detection voltage for each sensing channel. Each detection module 120 can be any detection chip 100 or sensor capable of detecting biomarkers. Taking the integrated sensor as an example, the detection module 120 can be a field effect transistor sensor. The field effect transistor sensor has a gate electrode with a biomolecular probe. The biomolecular probe is used for specific binding with a target detection substance in the biomarker, so that the field effect transistor sensor outputs a detection signal under the driving action of the target gear detection voltage. In addition, the field effect transistor sensor has a substrate, a channel layer on the substrate, a semiconductor layer on the channel layer, source and drain electrodes at both ends of the layer, a high dielectric constant dielectric layer on the semiconductor layer, and a gate electrode above the layer. The surface of the gate electrode is modified with a fixed biomolecular probe. When the biomarker to be detected contacts the biomolecular probe, the biomarker is detected by detecting the current change of the field effect transistor. Since the main control module 110 can also integrate a signal processing circuit, it can amplify, filter and digitize the detection signal from the field effect transistor, ensuring high sensitivity and high resolution of the signal. In addition, the detection chip 100 in the embodiment can also use advanced packaging metal to protect the detection modules 120 inside the detection chip 100, ensuring its long-term stability and reliability. The packaging material can be a material with good chemical stability.

[0039] In addition, the biomarker to be detected includes nucleic acid biomarkers of viruses, bacteria, fungi, chlamydia, antibodies, antigens, metabolic small molecules, ions, etc.

[0040] The detection chip 100 in the embodiment integrates a plurality of detection modules 120, which can control the plurality of detection modules 120 to drive the detection of biomarkers under the target gear detection voltage according to the detection instruction of the terminal 200, and can simultaneously detect a plurality of biomarkers, thereby improving the detection efficiency. That is, the detection chip 100 in the embodiment realizes the integration of molecular recognition, signal detection, signal analysis and signal transmission, realizes the simultaneous detection of multiple samples on the same chip, and provides a more efficient and reliable solution for multi-parameter detection. Compared with the current multi-parameter biological detection platform, the integration degree is higher, the portability is enhanced, and the detection application range is wider.

[0041] In one embodiment, referring to FIG. 2, FIG. 2 shows a structural schematic diagram of the master control module 110 in one embodiment of the present application (n detection modules 120 are shown in FIG. 2, n is a positive integer), the master control module 110 in this embodiment includes a driving unit 111, a sampling unit 112, a communication unit 113 and a control unit 114; the driving unit 111 is connected with the control unit 114 and the N detection modules 120 respectively; the sampling unit 112 is connected with the control unit 114 and the detection modules 120 respectively, for collecting detection signals and transmitting the detection signals to the control unit 114; the communication unit 113 is connected with the control unit 114, for communicating with the terminal 200 to transmit detection instructions to the control unit 114; the control unit 114 is used for controlling the driving unit 111 to output detection voltages of target gears to at least one of the detection modules 120 according to the detection instructions, and transmitting the detection signals to the communication unit 113, so that the communication unit 113 transmits the detection signals to the terminal 200.

[0042] The driving unit 111 can output detection voltages of target gears to the corresponding detection modules 120 under the control of the control unit 114, so as to drive the corresponding detection modules 120 to detect. The sampling unit 112 collects the detection signals of the detection modules 120, so that the control unit 114 can read the detection signals and transmit the detection signals to the terminal 200 through the communication unit 113. That is, the driving unit 111 can be any module, circuit or electronic device that can drive the detection modules 120 to work, and correspondingly, the sampling module can be any module, circuit or electronic device that can collect detection signals and convert the detection signals into a readable form for the control unit 114. The communication unit 113 can be a communication interface or a wireless communication component, that is, the control unit 114 and the terminal 200 can be connected by wired communication or wireless communication.

[0043] It should be noted that in other embodiments, the control unit 114 and the communication unit 113 can also be a control chip that is integrated, and are not necessarily two independent functional chips.

[0044] In this embodiment, the driving unit 111, the sampling unit 112, the communication unit 113 and the control unit 114 are used to realize independent control of each detection module 120 and processing and transmission of the detection signals, which can improve the detection efficiency of the detection chip 100 and the stability of signal transmission.

[0045] In one embodiment, the driving unit includes a digital-to-analog converter, for converting a digital electrical signal output by the control unit according to the detection instructions into an analog electrical signal detection voltage of the target gear, so that the detection module detects the biomarker under the driving action of the analog electrical signal detection voltage.

[0046] In the embodiment, the control unit and the digital-to-analog converter provide the detection voltage of the target gear for each detection module, and the flexible control of each detection module can be realized through the detection instruction of the terminal, thereby realizing high-accuracy biomarker detection.

[0047] In one embodiment, the sampling unit includes an analog-to-digital converter for converting the detection signal in the form of a digital electrical signal into an analog electrical signal and transmitting the analog electrical signal to the control unit.

[0048] In the embodiment, the high-sampling-rate analog-to-digital converter is configured to realize high-precision detection of the measured signal, ensure capturing subtle changes in the signal, and enhance the sensitivity of the detection chip to weak current changes, thereby realizing high-sensitivity and high-precision detection, improving the overall detection performance and reliability, and being suitable for fine analysis of weak current signals, such as pathogen detection.

[0049] In one embodiment, the communication unit includes a serial communication component or a Bluetooth component. In the embodiment, the Bluetooth component is used to realize the communication connection between the detection chip and the terminal, and the user can interact with the detection chip through the terminal, thereby improving the application scenarios of the detection chip.

[0050] It can be understood that in other embodiments, the communication unit can also be a wifi component or other types of communication components, without being limited thereto.

[0051] In one embodiment, the detection voltage is -1V-1V. In the embodiment, the detection voltage is set to -1V-1V, and different detection voltages of different gears can be provided to the detection module according to different biomarker types, that is, detection voltages of different voltage sizes, such as -1V, -0.8V, -0.6V, -0.4V, -0.2V, 0V, 0.2V, 0.4V, 0.6V, 0.8V, 1V, and the like, without being limited thereto. Therefore, any biomarker can be detected, and electrolysis of the sample containing the biomarker caused by excessively large detection voltage is avoided, thereby improving the applicability of the detection chip.

[0052] In one embodiment, the type of field effect transistor includes one of a metal oxide FET (Field Effect Transistor), a silicon FET, a graphene FET, and a transition metal dichalcogenide-based FET.

[0053] Exemplarily, referring to FIG. 3, FIG. 3 shows a structural schematic diagram of the field effect transistor sensor 121 in an embodiment of the present application. The field effect transistor sensor 121 shown in FIG. 3 includes a substrate 310, a semiconductor layer 320 arranged on a surface of the substrate 310, a channel layer 330 arranged on a surface of the semiconductor layer 320 away from the substrate 310, a dielectric layer 350 arranged on a surface of the channel layer 330 away from the semiconductor layer 320, a drain 360 and a source 340 respectively arranged on two ends of the dielectric layer 350, and a gate 370 arranged inside a surface of the dielectric layer 350 away from the channel layer 330. The gate 370 is provided with a biomolecular probe 380. The biomolecular probe 380 is used to specifically bind to a target detection object in a biomarker, so that the field effect transistor sensor 121 outputs a detection signal under the driving action of a detection voltage at a target gear. The semiconductor layer 320 used in the field effect transistor sensor 121 can include graphene, silicon, oxide semiconductor, polymer semiconductor, etc., and is not limited thereto.

[0054] In the embodiment, the field effect transistor sensor 121 provided with the biomolecular probe 380 is used as the detection module 120. Different biomolecular probes 380 can be modified in the gates 370 of different field effect transistor sensors 121 to realize detection of different biomarkers, thereby expanding the application range of the detection chip 100. In addition, when the biomolecular probe 380 binds to the target biomarker, even a weak detection signal can be detected under the cooperation of the host control module 110. Therefore, the detection module 120 in the embodiment also has higher detection sensitivity.

[0055] In one embodiment, the biomolecular probe includes one of an antibody, an enzyme, an organic small molecule, a single-stranded DNA, a double-stranded DNA, a two-dimensional DNA nanostructure, and a three-dimensional DNA nanostructure. In the embodiment, any of the above structures can be modified in the gates of different field effect transistor sensors to realize detection of various biomarkers, thereby improving the applicability of the detection chip in the embodiment.

[0056] In one embodiment, the detection chip further includes a metal packaging structure for packaging the host control module and the plurality of detection modules. In the embodiment, the metal packaging structure can protect the detection modules. The metal packaging structure has high stability and can protect the detection modules from being damaged by external environment, thereby prolonging the service life of the detection chip.

[0057] In one embodiment, referring to FIG. 4, FIG. 4 shows a second structural schematic diagram of the detection chip 100 in an embodiment of the present application (n field effect transistor sensors 121 are shown in FIG. 4, n is a positive integer), the detection chip 100 in the embodiment includes a digital-to-analog converter 1111, an analog-to-digital converter 1121, a CPU 1141 (central processing unit), a Bluetooth component 1131, and n field effect transistor sensors 121. The digital-to-analog converter 1111 corresponds to the driving unit 111 in any of the above embodiments, the analog-to-digital converter 1121 corresponds to the sampling unit 112 in any of the above embodiments, the CPU 1141 corresponds to the control unit 114 in any of the above embodiments, the Bluetooth component 1131 corresponds to the communication unit 113 in any of the above embodiments, and the n field effect transistor sensors 121 correspond to the plurality of detection modules 120 in any of the above embodiments. The connection relationship and functions are the same as those of the corresponding units and modules in any of the above embodiments, and will not be described here.

[0058] Exemplarily, the structure of the digital-to-analog converter 1111 can be as shown in FIG. 5, the structure of the analog-to-digital converter 1121 can be as shown in FIG. 6, and the Bluetooth component 1131 and the CPU 1141 can be integrated into the same chip, as shown in FIG. 7, which shows a structural schematic diagram of an integrated chip integrating the Bluetooth component 1131 and the CPU 1141.

[0059] In the embodiment, the field effect transistor sensors 121 capable of detecting a plurality of biomarkers are integrated into the same chip to realize signal detection, signal processing, and signal transmission, the detection voltage of each field effect transistor sensor 121 is flexibly controlled by the CPU 1141, the current of the detected signal is detected and processed with high precision, the related information of the detected biomarkers (i.e., the related information of the detection point) is displayed to the terminal 200 in a wireless communication manner, and the embodiment has the advantages of high integration, high sensitivity, high precision, easy expansion, high portability, and the like.

[0060] In one embodiment, referring to FIG. 8, FIG. 8 shows a structural schematic diagram of the detection device 10 in an embodiment of the present application, the detection device 10 in the embodiment includes the terminal 200 and the detection chip 100 in any of the above embodiments, and the terminal 200 is in communication connection with the detection chip 100.

[0061] It can be understood that when the detection chip 100 has further technical effects compared with the prior art, the detection device 10 in the embodiment also has further technical effects correspondingly due to the inclusion of the detection chip 100.

[0062] Any combination of the technical features in the above-described embodiments can be made, and for the sake of brevity, not all possible combinations are described, however, it is to be understood that the application encompasses all such possible combinations.

[0063] The above-described embodiments only express several implementation manners of the application, and the description is relatively specific and detailed, but it should not be understood as a limitation on the scope of the application. It should be pointed out that for ordinary skilled persons in the art, several modifications and improvements can be made without departing from the concept of the application, and these all belong to the protection scope of the application. Therefore, the protection scope of the patent of the application should be subject to the appended claims.

Claims

1. A detection chip, characterized by, The detection chip comprises a master control module and a plurality of detection modules; the master control module is connected with the plurality of detection modules, is used for connecting a terminal to receive a detection instruction from the terminal, and provides a detection voltage of at least one gear to the plurality of detection modules under the action of the detection instruction; each detection module detects a biomarker under the driving action of the detection voltage of a target gear to output a detection signal; the biomarker detected by each detection module is not completely the same, and the target gear of the detection voltage received by each detection module corresponds to the biomarker; each detection module comprises a field effect transistor sensor, a biomolecular probe is arranged in the gate of the field effect transistor sensor, and the biomolecular probe is used for specific binding with a target detection object in the biomarker to enable the field effect transistor sensor to output the detection signal under the driving action of the detection voltage of the target gear; The master control module is further used for transmitting the detection signal to the terminal.

2. The detection chip of claim 1, wherein, The master control module comprises a driving unit, a sampling unit, a communication unit and a control unit; the driving unit is connected with the control unit and N plurality of detection modules respectively; the sampling unit is connected with the control unit and a plurality of detection modules respectively, is used for collecting the detection signal, and transmits the detection signal to the control unit; the communication unit is connected with the control unit, is used for communication connection with the terminal, and transmits the detection instruction to the control unit; the control unit is used for controlling the driving unit to output the detection voltage to at least one of the plurality of detection modules according to the detection instruction, and transmitting the detection signal to the communication unit, so that the communication unit transmits the detection signal to the terminal.

3. The detection chip of claim 2, wherein, The driving unit comprises a digital-to-analog converter, which is used for converting a digital electrical signal output by the control unit according to the detection instruction into the detection voltage of an analog electrical signal of a target gear, so that the detection module detects the biomarker under the driving action of the detection voltage of the analog electrical signal.

4. The detection chip of claim 2, wherein, The sampling unit comprises an analog-to-digital converter, which is used for converting the detection signal in the form of a digital electrical signal into the form of an analog electrical signal and transmitting to the control unit.

5. The detection chip of claim 2, wherein, The communication unit comprises a serial communication component or a Bluetooth component.

6. The detection chip according to any one of claims 1 to 5, characterized in that, The detection voltage is-1V~1V.

7. The detection chip of claim 1, wherein, The type of the field effect transistor comprises one of a metal oxide FET, a silicon FET, a graphene FET and a transition metal dichalcogenide FET.

8. The detection chip of claim 7, wherein, The biomolecular probe comprises one of an antibody, an enzyme, an organic small molecule, a single-stranded DNA, a double-stranded DNA, a two-dimensional DNA nanostructure and a three-dimensional DNA nanostructure.

9. The detection chip of claim 1, wherein, The detection chip further comprises a metal packaging structure, and the metal packaging structure is used for packaging the master control module and the plurality of detection modules.

10. A detection device, characterized in that It comprises: a terminal; the detection chip according to any one of claims 1 to 9, which is in communication connection with the terminal.

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