Organ transport

Abstract

In a first aspect, an organ transport system is disclosed. The system comprises a fluid circuit for circulating a perfusion fluid, and a receptacle to receive the organ, wherein the receptacle comprises a base and side walls defining a receiving cavity to accommodate a portion of the organ on the base. In a further aspect, a method for operating the organ transport system, is provided. The method comprises circulating a perfusion fluid through a fluid circuit and providing the receptacle comprising the receiving cavity configured to receive the organ.

Description

[0001] Organ transport

[0002] The present application claims the benefit and priority of EP24382894.4, filed on August 8, 2024.

[0003] The present disclosure relates to organ transport systems, receptacles of the organ transport systems, and methods for operating the organ transport systems. Furthermore, perfusion fluids are disclosed as well.

[0004] BACKGROUND

[0005] Organ or tissue transplant is a procedure to replace an organ or tissue from one patient with a healthy organ from a donor. The number of donor organs available for transplant is usually lower than the number of patients who need to receive the organ. The difference between the supply and demand of organs for transplant has an upward trend due to both the reduction of optimal organs available and the increase in demand.

[0006] Organs have to be transported from the place where the donation takes place to the place where the patient who is to receive the organ is located. If the transport is not carried out under suitable conditions, the organ may suffer damage that may prevent it from being implanted.

[0007] Therefore, inadequate transport can reduce the number of organs available for transplant.

[0008] The present disclosure provides examples of systems, receptacles, fluids and methods that at least partially resolve some of the aforementioned disadvantages.

[0009] SUMMARY

[0010] In a first aspect, an organ transport system, is disclosed. The system comprises a fluid circuit for circulating a perfusion fluid to be fed to an organ. The system comprises a receptacle configured to receive the organ, wherein the receptacle comprises a base and side walls defining a receiving cavity, the base is configured to deform, at least partially, when supporting the organ to accommodate the shape of at least a portion of the organ. According to this aspect, the organ may be supported by the base that may flex under the weight of the organ itself. The base may flex relative to the rest of the receptacle when supporting the organ. This way, the organ is supported on a relatively soft surface, and damage from relatively hard surfaces on the organ may be avoided.

[0011] The base may be adapted to the anatomy of the organ. The organ may be supported by the base, whereby displacement of the organ relative to the receptacle may be reduced or even avoided during transport. The base that has flexible or elastic properties may dampen the inertial force generated on the organ due to transport, e.g. acceleration, deceleration and turning.

[0012] Therefore, the system according to this aspect may avoid or at least reduce damage to the organ. This may involve improved transport conditions. Improved transport conditions may enhance the availability of suitable organs. Thus, the system may increase the pool of grafts available for transplantation.

[0013] In a further aspect, a method for operating an organ transport system is disclosed. The method comprises circulating a perfusion fluid through a fluid circuit, wherein the fluid circuit is configured to feed the perfusion fluid to the organ. The method comprises providing a receptacle configured to receive an organ, wherein the receptacle comprises a base and side walls defining a receiving cavity, the base is configured to deform, at least partially, when supporting the organ to accommodate the shape of at least a portion of the organ.

[0014] In a yet further aspect, a receptacle to be held by an organ transport system according to any of the examples disclosed herein is provided.

[0015] In a yet further aspect, a perfusion fluid to be fed to an organ held by an organ transport system according to any of the examples disclosed herein is provided.

[0016] In a yet further aspect, a remote-control station is disclosed. The remote-control station is configured to be in data communication with the control unit of an organ transport system according to any of the examples disclosed herein.

[0017] Advantages derived from these aspects may be similar to those mentioned regarding the first aspect. The systems, devices, compounds, and methods of the present disclosure may be related to or based on the normothermic machine perfusion (NMP) approach and / or sub-normothermic machine perfusion approach. For example, the system may be a normothermic perfusion system and the method may be a normothermic perfusion method. The normothermic approach may comprise a stabilized temperature between 36 and 37.5 degrees.

[0018] The systems, devices, compounds, and methods of the present disclosure may be related to an organ or tissue in an ex-vivo scenario, i.e. out of the body.

[0019] In the present disclosure, the term organ, graft or tissue involves a human organ, graft or tissue.

[0020] In the present disclosure, expanded or increased criterion may refer to a criterion for indicating that a graft or donor does not meet standard or ideal conditions. The expanded criteria may be related to worse conditions than the standard or ideal conditions, for instance a significantly high age donor.

[0021] A deformable or flexible base of the herein disclosed methods and systems may be regarded as a base able to substantially vary, at least partially, its general shape by applying pressure thereto. The force required for deforming the container may be provided by the weight of the organ to be carried and / or the operation of any suitable pressure actuator configured to apply pressure to at least the base of the receptacle.

[0022] An object, part, device or the like, made from a flexible material of the herein disclosed methods and devices may be regarded as an object able to recover an original shape after it has been deformed by applying force thereto. The object may recover the previous shape when the organ is removed and / or the pressing actuator is switched off.

[0023] Throughout the present disclosure, the expression “in use” is to be understood as a system status when operated, i.e. performing at least one action related to the transport and perfusion of perfusion fluid through the organ.

[0024] BRIEF DESCRIPTION OF THE DRAWINGS Non-limiting examples of the present disclosure will be described in the following, with reference to the appended drawings, in which:

[0025] Figure 1 schematically illustrates an organ transport system according to an example of the present disclosure;

[0026] Figure 2 schematically illustrates a perspective view of a receptacle according to an example of the disclosure;

[0027] Figure 3 schematically illustrates a side view of the receptacle of Figure 2 according to one example of the present disclosure;

[0028] Figure 4 schematically illustrates a plan view of the receptacle of Figure 2 according to one example of the present disclosure;

[0029] Figure 5 schematically illustrates a perspective view of the receptacle of Figure 2 seen from a different angle according to one example of the present disclosure;

[0030] Figure 6 schematically illustrates a perspective view of a cross section of the receptacle of Figure 2 according to one example of the present disclosure;

[0031] Figure 7 schematically illustrates an organ transport system according to an example of the present disclosure;

[0032] Figure 8 schematically illustrates a view of a control unit of a system according to one example of the present disclosure;

[0033] Figure 9 schematically illustrates a view of the control unit and a sensor of the system according to one example of the present disclosure;

[0034] Figure 10 schematically illustrates a view of the control unit and a remote control station according to one example of the present disclosure;

[0035] Figure 11 schematically illustrates a plan view of the pressure actuator according to an example of the present disclosure;

[0036] Figure 12 schematically illustrates a side view of the receptacle and the pressure actuator according to an example of the present disclosure;

[0037] Figure 13 schematically illustrates a receptacle and a fluid circuit according to an example of the present disclosure;

[0038] Figure 14 schematically illustrates a receptacle and a fluid circuit according to a further example of the present disclosure; and

[0039] Figure 15 is a flow chart schematically illustrating a method for operating an organ transport system according to an example of the present disclosure.

[0040] DETAILED DESCRIPTION OF EXAMPLES

[0041] In these Figures, the same reference signs have been used to designate matching elements.

[0042] The examples of methods disclosed herein are not constrained to a particular order.

[0043] Figure 1 schematically illustrates an organ transport system 100 according to an example of the present disclosure. The organ transport system 100 of Figure 1 comprises a fluid circuit 200 for circulating a perfusion fluid to be fed to a tissue or organ 1. The perfusion fluid may be circulated through the cardiovascular system of the tissue or organ.

[0044] The organ transport system 100 comprises a receptacle 300 which is configured to receive the organ 1. The receptacle 300 comprises a base 310 and side walls 320 that define a receiving cavity 330. The base 310, or at least a portion of the base 310, is configured to deform when supports the organ 1 to accommodate the shape of at least a portion of the organ 1. The organ 1 has been illustrated in dotted lines for the sake of clarity. The organ 1 is born or supported by the base 310.

[0045] The deformation of base 310 of Figure 1 has been magnified for the sake of clarity.

[0046] The base 310 of Figure 1 is substantially elastically deformed because the organ 1 rests on the base 310. The deformed region of the base 310 may substantially fit the shape of organ 1 when seen from above. The base 310 may be at least partially deformed. The elastic deformation may be caused by the weight of the organ itself. A change of the shape of the base 310 may occur as a reaction to the applied weight of the organ over the base. A deformed position of base 310 may be defined when organ 1 is positioned on base 310 as in the illustrated example. The base 310 may show a substantially flat or smooth configuration when no organ is located thereon. An original position of the base 310 may be defined when the receptacle has no organ received inside. The original position may comprise a generally planar configuration.

[0047] Figures 2 to 5 schematically illustrate different views of the receptacle 300 according to examples of the disclosure. The examples, of these Figures 2 to 5 do not include the organ. The base 310 in these examples comprises the above mentioned original position. The illustrated receptacle 300 comprises a generally rectangular base 310 and four side walls 320 arranged in the perimeter of the base 310. The receptacle 300 of the Figures comprises a generally rectangular cuboid configuration or orthogonal parallelepiped configuration. The receptacle 300 may comprise a base 310 that has different shapes, such as squared, rounded, etc. The holding edge 323 may comprise substantially the same shape as the base 310, for instance when seen from above.

[0048] The receptacle 300 may comprise a fluid-tight configuration. In some examples, at least the base 310 may comprise a fluid-tight configuration. This way, the receptacle 300 and so the receiving cavity 330 may be filled with or store perfusion fluid and the fluid is securely maintained at least in the receiving cavity.

[0049] As can be seen in Figure 2, the side wall 320 comprises a lower side portion 321 connected to the base 310 and an upper side portion 322. The receptacle 300 may comprise a holding edge 323 to hold and / or support the receptacle 300. The holding edge 323 may be defined by the upper side portions 322 of the receptacle 300. The upper side portion 322 may comprise a more rigid configuration than the lower side portion 321 . Thus, the holding edge 323 may act as a structural part to hold or support the rest of the receptacle 300.

[0050] The base 310 may comprise a deformable supporting region 311 to accommodate the organ 1. The deformable supporting region 311 may be deformed to fit or suit the anatomy of organ 1 , at least partially. The deformable supporting region 311 may be the portion of base 310 that is elastically deformed when supporting organ 1.

[0051] In some examples, the deformable supporting region 311 may extend only over a part of the base 310. In some examples, the receptacle 300 may be made from a biocompatible material, such as silicone. The receptacle 300 may be made from a medical-grade polymer. In some examples, different parts of the receptacle 300 may be made from different materials. The receptacle 300 may be made from a material suitable for sterilization and being reusable.

[0052] In some examples, the base 310 may be made from a different material from at least a part of the side wall 320. The material of the base 310 may be more flexible than the rest of the receptacle 300. This way, the base 310 may be elastically deformed when the receptacle receives organ 1 and the rest of the receptacle may substantially maintain its shape.

[0053] In some examples, the deformable supporting region 311 may be made from a different material from at least a part of the side wall 320. The deformable supporting region 311 may be made from a more flexible material than at least a part of the side wall 320.

[0054] In examples, the deformable supporting region 311 may be made from a different material from the upper side portion 322. The deformable supporting region 311 may be made from a more flexible material than the upper side portion 322.

[0055] Figure 6 schematically illustrates a perspective view of a cross section of the receptacle 300 of Figure 2 according to one example of the present disclosure. In the example of Figure 6, the width of the cross section of the receptacle varies. The receptacle 300 of Figure 6 may be made from the same material but some parts of the receptacle 300 may comprise a wider or thinner cross section than other parts. The thinner parts may be more flexible than the wider parts. The thinner parts may elastically deform at a greater extent than the wider parts.

[0056] In examples, the base 310 may comprise a thinner cross section than the cross section of at least a part of the side wall 320. This way, at least a portion of the base 310 may deform when receiving the organ 1 , and the side wall 320 may remain substantially unchanged. When the base 310 comprises a thinner cross section than at least a part of the side wall 320, the base 310 may be made from the same material as the side wall.

[0057] In some cases, the width of the cross section of the side walls 320 gradually varies from a thinner lower side portion 321 to a wider upper side portion 322.

[0058] When the base 310 comprises a deformable supporting region 311 , the deformable supporting region 311 may comprise a thinner cross section than the cross section of at least a part of the side wall 320. The deformable supporting region 311 may comprise a thinner cross section than the cross section of the upper side portion 322. Thus, the deformable supporting region 311 may be deformed when supporting organ 1 while the upper side portion 322 may substantially maintain the shape. Therefore, the holding edge 323 acting as a supporting or holding part of the receptacle may remain substantially undeformed. This way, the receptacle 300 may be suitably supported by and attached to the rest of the organ transport system 100 when the receptacle carries at least, the organ 1.

[0059] As can be seen in Figure 2, the receptacle 300 comprises an entrance port and / or an exit port 325 arranged in the side wall 320. The entrance port and / or exit port 325 may comprise a hole to arrange fluid connections. The fluid connections may be configured to connect fluid circuit 200 from / to organ 1 or at least the receiving cavity 330. The fluid circuit 200 may comprise cannula, tubes, conduits, or the like to be connected to organ 1 and / or the receiving cavity 330. In some examples, the entrance port and / or the exit port 325 comprise a Luek lock. The number and location of the entrance port and / or the exit port 325 may vary depending on the case. The diameter of the cannula, tubes, or conduits to be connected to the organ 1 may vary depending on the case.

[0060] According to some examples, the deformable supporting region 311 may comprise a generally plate-like or laminae-like configuration. The base 310 may comprise a draining channel 312 between the deformable supporting region 311 and at least a lateral wall 320. An angle a may be defined between the deformable supporting region 311 and the direction of the path of the draining channel 312. The angle may be chosen depending on the case. Therefore, the perfusion fluid 312 may leave the receiving cavity 330 at least by gravity.

[0061] The draining channel 312 may protrude from the base 310, at least partially. The draining channel may be arranged in such a way that a part of the draining channel protrudes from the base 310 to a greater extent than the rest of the draining channel. This way, the draining channel 312 may slope or slant in use.

[0062] The draining channel 312 may be arranged among the deformable supporting region 311 and at least a pair of the side walls 320 so that the draining channel 312 is arranged with respect to at least a part of the perimeter of the deformable supporting region 311.

[0063] In the example of Figure 5, the receptacle 300 comprises a draining channel 312 on three different sides of the base 310, in such a way that the draining channel 312 may comprise a U-shaped configuration when seen from above.

[0064] The receptacle may comprise a draining hole 313 arranged in the draining channel 312. A draining pump 220 may be in fluid communication with the draining hole 313. The draining pump 220 may help to evacuate the perfusion fluid from the receiving cavity 330 in a controlled way. As the draining hole 313 is arranged in the draining channel 312, no suction force is applied to the organ 1 if the system 100 comprises the draining pump 220.

[0065] The draining hole 313 may be arranged in the deepest portion of the draining channel 312 with respect to the laminar element.

[0066] Figure 7 schematically illustrates an organ transport system 100 according to an example of the present disclosure. The deformation of the base of the receptacle 300 has been magnified for the sake of clarity.

[0067] In the example of Figure 7, the organ transport system 100 comprises a system frame 400 configured to support, at least, the fluid circuit 200 and the receptacle 300.

[0068] The organ transport system 100 may comprise a receptacle holding structure 410 to hold the receptacle 300. The receptacle holding structure 410 may be releasably attached to the system frame 400. In some examples, the receptacle 300 may be suspended from the receptacle holding structure 410, and so from the system frame 400. The receptacle 300 may be suspended from the receptacle holding structure 410 through the holding edge 323. This way, an interaction between the base 310 and the receptacle holding structure 410 may be avoided. Thus, the risk of organ 1 hitting or contacting the more rigid receptacle holding structure 410 may be avoided.

[0069] The upper side portion 322 of the side wall 320 may be configured to be releasably attached to the receptacle holding structure 410. Thus, the holding edge 323 may be configured to be releasably attached to the receptacle holding structure 410. The holding edge 323 may comprise mating features for mating with complementary mating features of the receptacle holding structure 410. Furthermore, the holding edge 323 may comprise a retention tab 324 to releasably retain the holding edge 323 with respect to the receptacle holding structure 410.

[0070] The holding edge 323 of the illustrated examples comprises a generally rectangular or squared-shaped configuration. The receptacle holding structure 410 may comprise an L-shaped or U-shaped configuration to embrace, at least partially, the holding edge 323.

[0071] In some examples, the receptacle 300 may comprise a lid 340. The lid 340 may protect the organ 1 from the outside while may prevent the perfusion fluid from flowing out the receiving cavity 330. The lid 340 may comprise a control window. The control window may be made from a transparent material. In some examples, the side walls 320 may comprise a control window as well.

[0072] In the example of Figure 7, the receptacle holding structure 410 comprises a vertical adjusting device 411 to adjust a vertical position of the receptacle 300 relative to the system frame 400. This way, the receptacle 300 may be suitably adapted to the height of the user.

[0073] In some examples, the fluid circuit 200 comprises at least one inlet line 210 that may fluidly communicate a circuit reservoir 230 with the organ 1 and / or the receiving cavity 330. The inlet line 210 may be configured to be fluidly connected to a blood vessel of the organ 1 to supply perfusion fluid to the organ 1. In some examples, the inlet line 210 may comprise a plurality of lines such as a first inlet line 211 and a second inlet line 212.

[0074] In some examples, the fluid circuit 200 comprises at least one outlet line 220 configured to be fluidly connected to the receiving cavity 330 and / or the organ 1. The outlet line 220 may be configured to receive at least perfusion fluid. The outlet line 220 may fluidly communicate the organ 1 and / or the receiving cavity 330 with the circuit reservoir 230.

[0075] The fluid circuit 200 of Figure 7 comprises an inlet line 210 and an outlet line 220. The perfusion fluid 231 may be stored in the circuit reservoir 230. The fluid circuit 200 comprises a driving pump 240 to drive perfusion fluid from the circuit reservoir 230. The organ transport system 100 may comprise a driving pump for each of the above mentioned plurality of inlet lines. For instance, the driving pump 240 comprises a first driving pump associated with the first inlet line, and a second driving pump associated with the second driving pump.

[0076] The fluid circuit 200 of the illustrated example comprises a draining pump 223 to drive the perfusion fluid 231 to the circuit reservoir 230. The draining pump 223 may be arranged in the outlet line 220 and may be configured to be in fluid communication with the organ 1 and / or receiving cavity 330 and the circuit reservoir 230. However, the fluid circuit 200 may be void of the draining pump 223, for instance, when the inlet line 210 and the outlet line 220 are fluidly connected to the organ 1. The driving pump 240 may be able to drive the perfusion fluid when the fluid circuit 200 is void of the draining pump 223.

[0077] In some non-illustrated examples, the fluid circuit 200 may be void of the circuit reservoir. Then, the fluid circuit comprises a main line in fluid communication with the driving pump 240. The perfusion fluid can be provided to the organ 1 from a feeding end of the main line. The main line may comprise a draining end to receive at least perfusion fluid from the organ and / or receiving cavity.

[0078] The system 100 may comprise at least one of a temperature sensor, an inlet pressure sensor, a flowmeter, a pH sensor, a gas sensor, an oxygen sensor, a glucose sensor, a lactate sensor, or a combination thereof. In the present disclosure, the sensor or sensors have been illustrated as a single member 290 for the sake of clarity. However, if the system 100 comprises a plurality of sensors 290, the plurality of sensors may be arranged at different locations of the system 100, such as locations associated with the fluid circuit 200 and / or the receptacle 300.

[0079] In some examples, the temperature sensor may comprise an infrared temperature sensor.

[0080] In some examples, the system 100 may comprise a near-infrared spectroscopy (NIRS) sensor configured to sense at least one of hemoglobin, hematocrit, and oxygen saturation in the perfusion fluid. The NIRS sensor may be also configured to sense partial pressure of oxygen (pCh), partial pressure of carbon dioxide (pCCh), pH, and potassium concentration (K+).

[0081] The organ transport system 100 may comprise a pressure actuator 500 configured to apply pressure on the base 310. The pressure actuator may be configured to vary the pressure distribution over the base 310 or at least the deformable supporting region 311 . The pressure distribution may be varied over a predetermined period. As the pressure may be applied to different and changing regions of the base 310, the pressure actuator 500 may avoid or at least reduce overpressure on the organ 1. Reducing overpressure may mean reducing risk of ischemic injuries or even necrosis in the graft.

[0082] The pressure actuator 500 may be releasably attached to the system frame 400, for instance to the receptacle holding structure 410. The organ transport system 100 may comprise a distance adjusting mechanism 550 to adjust the distance between the pressure actuator 500 and the receptacle 300, for instance, the base 310. The distance adjusting mechanism 550 is configured to move the pressure actuator 500 relative to the receptacle 300. In the example of Figure 7, the pressure actuator 500 is attached to the receptacle holding structure 410 through a link, and the distance adjusting mechanism 550 is arranged in the link. The length of the link may be adjusted.

[0083] In the example of Figure 7, the organ transport system 100 comprises a control unit 150. Sensors 290 may be in data communication with the control unit 150. The control unit 150 may be configured to control the operation of the driving pump 240 and / or the draining pump 223. The control unit 150 has been schematically illustrated in the organ transport system 100, the location of the control unit 150 within the organ transport system 100 may vary. The control unit 150 may be separate from the receptacle 300 and the fluid circuit 200 in such a way that fluids of the system 100 cannot reach the control unit 150.

[0084] The organ transport system 100 may comprise a battery 110 to feed electric devices with power, as well. Battery and any other relatively heavy part may be located in the bottom portion of the system frame 400 in order to lower the centre of gravity of system 100. The heaviest parts of the system may be located in the bottom portion of the system frame 400 to lower the centre of gravity and enhance the handling and stability of the system 100 during transportation.

[0085] The system frame 400 may comprise wheels 450 to easily move the organ transport system 100. The wheels 450 may be lockable to avoid any undesired movement of the organ transport system 100. The wheels may be associated with an electric motor or the like to assist the motion of the system 100. The system frame 400 may comprise walls, doors, or the like to enclose parts of the system. Therefore, the components of system 100 may be protected during a trip from the donor site to the patient site to receive the graft.

[0086] The system frame 400 may be designed to be compatible with any kind of vehicle usually employed in organ transportation. The frame 400 may include anchoring features configured to be releasably attached to a vehicle or the like.

[0087] Figure 8 schematically illustrates a view of control unit 150 of a system according to one example of the present disclosure. Figure 9 schematically illustrates a view of the control unit 150 and a sensor 290 of the system 100 according to one example of the present disclosure. Figure 10 schematically illustrates a view of the control unit 150 and a remote-control station 160 according to one example of the present disclosure.

[0088] Details of the control unit 150 described related to Figure 8 could be indistinctly applied to a remote-control station 160.

[0089] The control unit 150 may comprise a controller 151. The controller 151 may be a processor, a chip, a computational device, or processing resources that executes sequences of machine-readable instructions contained in a memory. Controller 151 performs operations on data. The memory may be a non-transitory machine-readable storage medium 152. As can be seen in Figure 8, the non-transitory machine-readable storage medium 152 is coupled to the controller 151. Examples of a non-transitory machine-readable storage medium may include a memory device, a floppy disk, a compact disk (CD), a digital versatile disk (DVD), a USB drive, a computer memory, a read-only memory, or other devices that may store computer code.

[0090] The machine-readable instructions may be carried on a carrier signal such as an electrical or optical carrier signal.

[0091] The machine-readable instructions may comprise a computer program(s) in the form of source code, object code, a code intermediate source, and object code such as in partially compiled form, or in any other form suitable for use in implementing the methods according to the present disclosure.

[0092] The control unit 150 may be configured to receive user input through a user interface. The user interface may be arranged or supported in the system 100. The user input may comprise the machine-readable instructions related to the operation of the system 100. The control unit 150 may be configured to receive user input from a remote-control station 160. The control unit 150 may be in data communication with at least one of the user interfaces, the sensor, the remote-control station, or a combination thereof.

[0093] The user input may comprise initial values and target values of the parameters related to the perfusion process over a predetermined period. For instance, initial values of temperature and pressure of the perfusion fluid, and target values of temperature and pressure over a period. The user may introduce initial or starting values of the parameters depending on the condition of the organ or tissue as received from the donor, e.g. expanded criteria donor. The user may introduce target values of the parameters and estimated duration of the perfusion to recover the organ or tissue from the initial stage. This way, the recipient may receive the graft in suitable conditions.

[0094] In some examples, the control unit may be configured to compute duration of the perfusion in order to provide the graft or tissue with suitable conditions for transplant. The control unit may be configured to run an operation algorithm.

[0095] In some cases, the operation algorithm may be based on artificial intelligence. The operation algorithm may be trained using cases of expanded criteria grafts, including starting parameters, and target parameters, with an associated duration label and parameters over time (between starting point and target point).

[0096] In one example, the operation algorithm may comprise a neural network, such as an artificial neural network. However, the algorithm may comprise examples of machine learning algorithms, such as a deep learning algorithm. The neural network of the operation algorithm may be trained using the above training data with an associated duration label and parameters over time. A training method for the estimation algorithm is disclosed.

[0097] The control unit 150 may be configured to receive sensing input or data from the sensors 290 that measure parameters related to the perfusion. The sensing input or data from the sensors 290 may be sensing data. The communication between the sensors and the control unit 150 may be by wire or wireless. The control unit 150 may be configured to regulate the various elements of the system 100 based on, inter alia, the sensing data received from the sensors 290. In examples, the sensing data may comprise at least one of hematocrit in the perfusion fluid, hemoglobin in the perfusion fluid, oxygen saturation in the perfusion fluid, pH in the perfusion fluid, oxygen partial pressure, partial pressure of carbon dioxide, bicarbonate level, and / or potassium level.

[0098] The control unit 150 may determine whether the received sensing data comprise a sensing value above or below a predetermined threshold sensing value. The threshold sensing value may be determined depending on the parameter. In some examples, the threshold sensing value may be included in the user input.

[0099] According to some examples, the control unit 150 may be configured to trigger an alarm signal when the sensing value is above or below a predetermined threshold sensing value. The alarm signal may be received by a suitable alarm device to produce an alarm perceptible by a user.

[0100] The control unit 150 may be configured to produce the alarm signal including an alarm parameter. In examples, the alarm parameters may comprise timing, duration, and the type of involved sensing value. The timing may refer to the moment when the alarm is triggered. The duration may be defined between the starting point of the alarm and the instant when it ends. The kind of alarm signal may refer to the parameters involved in the alarm event, e.g. temperature, pressure, flow rate, etc.

[0101] The control unit 150 may be configured to determine an organ state index. The organ state index may comprise or may be related to an organ viability index. The value organ viability index may indicate whether the organ is susceptible to being used in a transplant or not. The control unit 150 may determine based on the alarm parameters an organ state index. For instance, if the alarm signal is related to an event of lack of urine or bile production over a period, the organ state index may be indicative that the organ is not viable. The organ viability index may indicate that the graft is not suitable for transplant. However, if no alarm signal is produced or the alarm parameters are not considered serious the organ state index may be indicative of viable. The organ viability index may indicate that the graft is suitable for transplant.

[0102] The control unit 150 may be also configured to determine the organ state index considering donor data such as age, gender, body mass index, cause of death, possible illnesses, and / or state of the graft. According to an example, the organ transport system 100 may comprise a communication device 153 in data communication with the control unit 150. The control unit 150 may be configured to establish data communication with the remote-control station 160 through the communication device 153. The control unit 150 may be configured to be remotely operated from the remote-control station 160.

[0103] In some examples, the control unit 150 may be configured to control the operation of the driving pump 240. For instance, the control unit 150 may receive flow sensing data related to the flow rate of perfusion fluid to be fed to the organ 1 , and / or pressure sensing data of perfusion fluid to be fed to the organ 1 that may flow through the inlet line 210. The control unit 150 may be configured to process pressure sensing data and / or flow sensing data, and to determine operation parameters of the driving pump 240 by verifying whether pressure sensing data and / or flow sensing data received from the sensors 290 satisfies a predetermined data threshold.

[0104] In some examples, the organ transport system 100 may comprise a positioning device 154 in data communication with the control unit 150. The positioning device may comprise a positioning transmitter and / or a positioning receiver. The control unit 150 may be configured to receive positioning data from the positioning device. In some examples, the control unit 150 may be configured to correlate the organ state index and positioning data.

[0105] The control unit may be configured to receive coordinates of the donor site and the coordinates of the transplant site. As the control unit may receive positioning data, the control unit may be configured to calculate or compute an expected duration of transportation. The control unit may be configured to calculate an estimated duration left.

[0106] The control unit may be configured to process the organ state index, the estimated transportation duration left using an estimation algorithm configured to produce an estimated organ state index at the transplant site. When the estimated organ state index is above or below an organ state index threshold, the control unit may be configured to produce an indication to select an alternative destination.

[0107] In some examples, coordinates of a plurality of suitable destinations may be introduced in the control unit. In these examples, the control unit may be further configured to process the coordinates of the plurality of suitable destinations and the estimated organ state index using the estimation algorithm configured to produce at least one alternative transplant site.

[0108] For instance, the control unit may receive coordinates of donor site and target site or transplant site. The control unit may calculate transportation duration left and determined the estimated organ state index. If the conditions of the organ during the transportations become worse then the estimated organ state index at the destination site may be unacceptable. The estimation algorithm may produce an indication of alternative destinations in which the estimated organ state index is acceptable. This way the number of refused organs may be reduced. A reduction in the number of refused organs may mean an increase in the pool of organs.

[0109] The estimation algorithm may comprise an artificial intelligence approach trained using organ state index, transplant sites, estimated transportation duration left with associated estimated organ state index label. In some cases, the estimation algorithm may be trained further with associated alternative destination labels.

[0110] In one example, the estimation algorithm may comprise a neural network, such as an artificial neural network. However, the estimation algorithm may comprise examples of machine learning algorithms, such as a deep learning algorithm. The neural network of the estimation algorithm may be trained using the above training data with an associated estimated organ state index label, and / or even alternative destination labels. A training method for the estimation algorithm is disclosed.

[0111] In some cases, the estimation algorithm and the operation algorithm may be included in an algorithm system. Therefore, the algorithm system may perform the functions or operations related to the estimation algorithm and the operation algorithm. The control unit 150 or the remote-control station 160 may be configured to run the algorithm system.

[0112] Figure 11 schematically illustrates a plan view of the pressure actuator 500 according to an example of the present disclosure. Figure 12 schematically illustrates a side view of the receptacle 300 and the pressure actuator 500 according to an example of the present disclosure.

[0113] The pressure actuator 500 may be configured to apply pressure to a first target region 314 of the base 310. The pressure actuator may be configured to move relative to the base 310 to apply pressure to a second target region 315 different from the first target region 314.

[0114] In the illustrated examples, the pressure actuator 500 comprises a protrusion 511 , 512, 521 , 522 extending from a rotor 513, 523. The protrusion is configured to extend to the base 310. The base 310, or at least the deformable supporting region 311 , may be substantially deformed by the protrusion. In Figure 12, the pressure actuator 500 and the receptacle 300 have been illustrated spaced apart for the sake of clarity. The protrusions may comprise a generally rounded configuration or at least a partially rounded configuration.

[0115] The protrusion 511 , 512 is arranged in an off-centre position with respect to a rotation axis 515, 525 of the rotor 513, 523. The rotation axis 515, 525 may be substantially perpendicular to the base 310, or at least the deformable supporting region 311 . This way, a rotation of the rotor 513, 523 may cause the rotation of the protrusion 511 , 512 with respect to the rotation axis 515, 525. Since the protrusion moves about the rotation axis 515, 525, and so relative to the base 310, the pressure applied by a protrusion 511 , 512, 521 , 522 may be displaced from a first target region 314 to a second target region 315. In other words, the target regions 314, 315 may move as the rotor 513, 523 rotates about the rotation axis 515, 525.

[0116] In Figure 12, protrusions are illustrated spaced apart from the receptacle for the sake of clarity. As there is a distance between protrusions and base 310, the illustrated protrusions do not apply any pressure to the base 310.

[0117] The rotor 513, 523 may be a disc or arm configured to rotate following directions 514, 524. Although the rotation direction has been illustrated clockwise, the rotation direction could be counterclockwise as well. In some examples, the pressure actuator 500 may configured to change the rotation direction at a predetermined point in time. The rotor 513, 523 may be driven by an electric motor 530 controlled by the control unit 150. The control unit may be configured to manage the operation of the electric motor 530 depending on predetermined instructions. The control unit 150 may control operation features of the electric motor 530, such as rotation speed and / or clockwise or counterclockwise direction. The control unit 150 may control the timing and duration of operation of electric motor 530 as well.

[0118] In some examples, the control unit may be configured to manage the operation of the electric motor 530 depending on the inputs received from sensors 590. Control unit 150 may receive data on parameters of the perfusion fluid that may be related to the predetermined status of the organ 1. The electric motor 530 may start to rotate the rotor and so the protrusions, or the rotation speed may be increased and / or the rotation direction may be changed.

[0119] In the example of Figures 11 , 12, the pressure actuator 500 comprises a plurality of protrusions 511 , 512, 521 , 522 arranged in off-center positions with respect to the respective rotation axis 515, 525. If there are a couple of protrusions associated with the rotor, the protrusions may be arranged diametrically opposed to each other with respect to the rotation axis. If there are more than two protrusions, the protrusions may be arranged about the rotation axis in a regular manner. If there is a single protrusion, the protrusion may be arranged in any position spaced apart from the rotation axis.

[0120] The pressure actuator 500 may comprise the rotor 513, 523 and a plurality of protrusions, wherein each protrusion may have a different size from the rest. This can be seen in Figures 11 , 12. Different sizes may involve that each protrusion protrudes from the rotor and toward the base 310 to a different extent in a direction substantially parallel to the rotation axis 515, 525. Therefore, the intensity of the pressure exerted by the pressure actuator 500 may vary from one protrusion to another protrusion of different size. Furthermore, the degree of deformation of the base 310 caused by the protrusion may depend on the size of the protrusion. A greater size may cause a greater deformation and a smaller size may cause a smaller deformation.

[0121] As can be seen in Figures 11 , 12, there are positions on the rotor 513, 523 in which there are no protrusions. Therefore, these areas devoid of protrusions exert no or negligible pressure on the receptacle.

[0122] In some examples, the organ transport system 100 may comprise a plurality of pressure actuators 500. The examples of Figures 11 and 12 comprise a pressure actuator having two sets 510, 520 of rotor and protrusions. In Figure 11 , sets 510, 520 are arranged angularly offset or out of phase with respect to each other. Thanks to this the pressure distribution is improved / enhanced.

[0123] In the case of Figure 12, there is one set for each organ 1 , however, the number of sets may vary for each organ depending on each case. As can be seen in Figure 12, the base 310 is arranged, in use, between at least the pressure actuator 500 and the receiving cavity 330.

[0124] The organ transport system 100 may comprise a pad 540 between the pressure actuator 500 and the base 310. The pad 540 may be manufactured from a flexible material, for instance, silicone. The pad 540 may protect the pressure actuator 500 and other parts of the system 100 from any leakage of perfusion fluid from the receptacle 300. The pad 540 may isolate the receptacle 300 from the pressure actuator 500, so the pad 540 may help to reuse the pressure actuator. For the sake of clarity, pad 540 has been illustrated spaced apart from the receptacle 300.

[0125] The action of the pressure actuator 500 may be transmitted to the organ 1 received in the receptacle due to the flexible and / or deformable feature of the base 310, e.g. the deformable supporting region 311. The pressure actuator 500 may apply pressure points to the organ 1 that are rotating over the deformable supporting region 311 . The receptacle 300 may be suspended from the receptacle holding structure 410 via holding edge 323 while the pressure actuator 500 applies pressure on the base 310.

[0126] In some examples, the pressure of the pressure actuator 500 is exerted in a direction substantially opposite to the weight of the organ 1 in a position of use.

[0127] Although a pressure actuator 500 comprising rotary protrusions has been described in the present description, in other examples not illustrated, the pressure actuator 500 may comprise mechanisms for varying the pressure exerted on the base 310 overtime. In some examples, the pressure actuator 500 may comprise mechanical, pneumatic, or hydraulic systems.

[0128] Figure 13 schematically illustrates a receptacle 300 and a fluid circuit 200 according to an example of the present disclosure. Figure 14 schematically illustrates a receptacle 300 and a fluid circuit 200 according to a further example of the present disclosure.

[0129] In some examples, the organ 1 may comprise a liver as illustrated in Figure 13 and / or a kidney as illustrated in Figure 14. However, the organ transport system 100 may be used to carry organs apart from the liver and kidney, e.g. a heart or lung.

[0130] The inlet line 210 may comprise an oxygenator 270 to provide the perfusion fluid with oxygen. The oxygenator 270 may be in data communication with the control unit 150. The control unit 150 may receive oxygenation sensing data of the perfusion fluid in the inlet line 210 through the corresponding sensor 290. Thus, the amount of oxygen in the perfusion fluid to be fed to the organ may be adjusted depending on the case.

[0131] The inlet line 210 may comprise a bubble trap 275. This way, bubbles in the inlet line 210 may be removed. The bubble trap 275 may be arranged after the oxygenator 270.

[0132] The inlet line 210 may comprise a heat exchanger 280 to increase or reduce the temperature of the perfusion fluid in the inlet line. This way, the perfusion fluid may be fed to the organ at a suitable temperature to maintain a normothermic scenario or a hypothermic scenario. The heat exchanger 280 may be associated with the oxygenator 270 and / or any other element in the inlet line 210. Depending on the case, the heat exchanger may absorb or provide heat from / to perfusion fluid. The operation of the heat exchanger may be controlled by the control unit. The control unit may receive temperature data from sensor 290.

[0133] In some examples, the inlet line 210 may comprise a drainage valve 213 to drain at least a part of the perfusion fluid. The inlet line 210 may comprise a pressure buffer to avoid or at least reduce the risk of providing a perfusion fluid to the organ over a predetermined pressure value.

[0134] Furthermore, the inlet line 210 and / or the outlet line 220 may comprise a sample region to take fluid samples from the fluid circuit 200.

[0135] The outlet line 220 may comprise a dialyzer 250 or filter to filter or dialyze perfusion fluid from the organ or receiving cavity. In the examples of Figures 13 and 14, the outlet line 220 comprises a bifurcation. The bifurcation comprises a first way to the dialyzer 250 and a second way to the circuit reservoir 230. A valve or the like may be installed upstream of the bifurcation of the dialyzer 250. The valve may be operated manually or controlled by the control unit 150. This way, the amount of perfusion fluid 231 to be dialyzed may vary depending on the case. For instance, from 0% to 100% of the perfusion fluid flowing through the outlet line 220 may be dialyzed or filtered. In some cases, the amount to be dialyzed may vary over time during the same perfusion operation.

[0136] The dialyzer may be in data communication with the control unit 150. Therefore, the operation of the dialyzer may be controlled or monitored. The sensors 290 in outlet line 220 may provide the control unit 150 with data to command the operation of a dialyzer pump of a dialyzer circuit.

[0137] In the illustrated examples of Figures 13 and 14, the fluid circuit 200 comprises a metering port 261 , 262, 263 configured to receive fluid media. The fluid media may comprise any substance to be added to the perfusion fluid. The metering port may receive syringes or any other injectable container. The metering port may store a fluid media to be delivered to the perfusion fluid through a drug pump 264 commanded by the control unit 150. Thus, the amount, duration, and instant of the delivery may be automatically controlled.

[0138] The entrance port and / or the exit port 325 may be configured to receive, at least partially, tube, conduits, or the like of the inlet line 210 and / or the outlet line 220.

[0139] As can be seen in the example of Figure 13, the organ transport system 100 comprises a gall connection 350 configured to be fluidly connected to the gallbladder of the organ 1 , such as a liver. The gall connection 350 is fluidly connected to a gall reservoir 351. A bile flow sensor may be associated with the gall connection 350 to sense the bile of the transported liver. The control unit 150 may receive data from the bile flow sensor.

[0140] The fluid circuit 200 may comprise a first inlet line 211 to be fluidly connected to a hepatic artery to supply perfusion fluid, and a second inlet line 212 to be fluidly connected to a hepatic portal vein to supply perfusion fluid.

[0141] The fluid circuit 200 comprises a first outlet line 221 to be fluidly connected to the draining hole 313.

[0142] The first inlet line 211 comprises the first driving pump to drive perfusion fluid from the circuit reservoir 230 to be delivered to the hepatic artery of the liver in receptacle 300.

[0143] The second inlet line 212 is associated with the second driving pump 242. The second driving pump 242 is configured to drive the perfusion fluid from the circuit reservoir 230 to be delivered to the hepatic portal vein.

[0144] In the example shown in Figure 13, the perfusion fluid 231 can be disposed within the receptacle 300, for example, the receiving cavity 330. The draining pump 221 may be actuated by the control unit 150. The perfusion fluid 231 may then be passed through the draining hole 313 into the first outlet line 221. The amount of perfusion fluid 231 that passes through the dialyzer 250 may be regulated by the valve or the like that may be installed upstream of the bifurcation of the dialyzer 250. After that, the perfusion fluid 231 that has been flowing through the first outlet line 221 reaches the circuit reservoir 230. As can be seen, in this example the circuit reservoir 230 is in fluid connection with the metering ports 261 , 262, 263. Fluid media (not illustrated) may be provided to the perfusion fluid 231. In the case of the metering port 261 , there is provided medicament pump 264 controlled by the control unit 150.

[0145] The first driving pump 241 and / or the second driving pump 242 may be actuated by the control unit 150 to supply organ 1 with perfusion fluid 231. The first driving pump 241 is associated with the first inlet line 211 . The oxygenator 270 is provided in the first inlet line 211 for adjusting the amount of oxygen in the perfusion fluid to be provided to the hepatic artery. The heat exchanger 280 is provided for adjusting the temperature of the perfusion fluid to be provided to the hepatic artery and / or hepatic portal vein. The heat exchanger 280 may be controlled by the control unit 150. The heat exchanger 280 may increase or decrease the temperature of the perfusion fluid, depending on temperature data received by the control unit 150.

[0146] The second driving pump 242 is associated with the second inlet line 212. In the illustrated example, heat exchanger 280 also acts on the perfusion fluid running through the second inlet line 212 by means of a heating element 281 of the heat exchanger 280.

[0147] The control unit is configured to control the operation of the first driving pump 241 and / or the second driving pump 242. In this way, the flow rate flowing through the first inlet line 211 and / or the second inlet line 212 may be adjusted according to the flow rate expected to enter the hepatic artery and the portal vein. By regulating the flow rate of each of the inlet lines 211 , 212, the inflow pressure to the hepatic artery and portal vein may be regulated.

[0148] Perfusion fluid 321 that has already circulated through the liver may leave the organ and be collected by the draining channel 312. The perfusion fluid 321 may circulate through the draining channel 312 to the draining hole 313 and back through the fluid circuit 200 as described above.

[0149] In the example of Figure 13, the plurality of sensors may comprise a glucose sensor, a lactate sensor, a temperature sensor associated with the connection region between the first inlet line 211 and the hepatic artery, a temperature sensor associated with the connection region between the second inlet line 212 and the hepatic portal vein, a temperature sensor to sense temperature of the perfusion fluid within the receiving cavity 330, a flow rate sensor associated with the first inlet line 211 , a flow rate sensor 212 associated with the second inlet line 212, a pressure sensor associated with the connection region between the first inlet line 211 and the hepatic artery, a pressure sensor 212 associated with the connection region between the second inlet line 212 and the hepatic portal vein, a NIRS sensor, a bile sensor, and a level sensor associated with the receiving cavity 330 to sense the amount of perfusion fluid within the receiving cavity.

[0150] In the example of Figure 14, the fluid circuit 200 comprises a first inlet line 211 to be fluidly connected to a renal artery to supply perfusion fluid.

[0151] The fluid circuit comprises a second outlet line 222 to be fluidly connected to the renal vein to receive at least perfusion fluid from the organ, e.g. the kidney. The second outlet line is fluidly connected to the circuit reservoir 230 of the fluid circuit.

[0152] The control unit can be configured to control the operation of the first driving pump 241 . In this way, the flow rate flowing through the first inlet line 211 can be adjusted according to the flow rate expected to enter the renal artery. By regulating the flow rate of the first inlet line 211 , the inlet pressure to the renal artery may be regulated.

[0153] In the example shown in Figure 14, perfusion fluid 231 may be disposed in the interior circuit reservoir 230. The first driving pump 241 can be actuated by the control unit 150 to supply the organ 1 with perfusion fluid 231. The first driving pump 241 is associated with the first inlet line 211 . The oxygenator 270 is provided on the first inlet line 211 to adjust the amount of oxygen in the perfusion fluid to be provided to the renal artery. The heat exchanger 280 is provided to adjust the temperature of the perfusion fluid. As in the example of Figure 13, the heat exchanger 280 may be controlled by the control unit 150. The heat exchanger 280 may increase or decrease the temperature of the perfusion fluid, depending on the temperature data received by the control unit 150 and sensed by sensor 290, e.g. a temperature sensor.

[0154] The flow rate flowing through the first inlet line 211 may be adjusted according to the flow rate expected to enter the renal artery. By regulating the flow rate of the inlet line 211 , the inlet pressure to the renal artery may be regulated.

[0155] The perfusion fluid that has already circulated through the kidney may leave the organ and be collected by the second outlet line 222. The second outlet line 222 is configured to be fluidly connected to the renal vein.

[0156] The fluid reaches the dialyzer 250 through the second outlet line 222. In the example of Figure 14, it is provided that a portion of the perfusion fluid 231 may pass through the dialyzer 250 and the other portion of the perfusion fluid 231 may not. As in the previous case described in relation to the liver, a valve or the like may be installed upstream of the bifurcation of the dialyzer 250. The valve may be operated manually or controlled by the control unit 150. The perfusion fluid 231 flowing through the second outlet line 222 reaches the circuit reservoir 230. As can be seen, in this example the circuit reservoir 230 is in fluid connection with the metering ports 261 , 262, 263. Fluid media (not illustrated) may be provided to the perfusion fluid 231. In the case of the metering port 261 , there is provided a medication pump 264 controlled by the control unit 150.

[0157] In Figure 14, it can be seen that a ureter connection 225 that is configured to be in fluid connection with the kidney ureter and to the circuit reservoir 230. Fluid passing through the ureter connection 225 reaches the circuit reservoir 230. The system may comprise a urine flow meter associated with the ureter connection and configured to sense a urine flow rate. The urine flow meter may be in data communication with the control unit 150.

[0158] In the example of Figure 14, the plurality of sensors may comprise a glucose sensor, a lactate sensor, a temperature sensor associated with the connection region between the first inlet line 211 and the renal artery, a temperature sensor 212 associated with the output region of the oxygenator 270, a temperature sensor to sense temperature of the perfusion fluid within the receiving cavity 330, a flow rate sensor associated with the first inlet line 211 , a pressure sensor associated with the connection region between the first inlet line 211 and the renal artery, a pressure sensor associated with the connection region between the second outlet line 222 and the renal vein, a NIRS sensor, a urine sensor, and a level sensor associated with the receiving cavity 330 to sense the amount of perfusion fluid within the receiving cavity.

[0159] Figure 13 has been described in relation to a liver while Figure 14 has been described in relation to a kidney. However, the present system 100 may be used interchangeably with liver, kidney, or other organ or tissue transplant. The number of inlet lines and outlet lines may be chosen depending on the organ or tissue being transported. In some examples, the organ transport system 100 may comprise the configurations of the examples of Figures 13 and 14.

[0160] The manner of connecting the outlet line 220 may also be adapted to each case. For example, the outlet line may be connected directly to the organ or may be connected to the draining hole 313. The draining pump 221 may be present but not drive the perfusion fluid if it is not needed.

[0161] The manner of feeding the organ transportation system 100 with perfusion fluid may vary depending on the case. As above described related to the examples of Figures 13 and 14, the receptacle 300 and / or the circuit reservoir 230 may be filled with perfusion fluid before starting the perfusion to organ 1.

[0162] In some examples, the organ transport system 1 may comprise a system frame 400 according to any of the examples herein disclosed, a receptacle 300 according to any of the examples herein disclosed, and a plurality of functional sections. The functional sections may comprise: a fluid circuit section. The fluid circuit section may include the inlet line 210, the outlet line 220, the circuit reservoir 230, the draining pump 220 (if any), the oxygenator 270, the bubble trap, and the heat exchanger 280; a sensor section. The sensor section may include the sensors 290 to be associated with the fluid circuit 200 and / or the receptacle 300; a ureter section. This ureter section may comprise the ureter connection 225; a dialyzer section. The dialyzer section may comprise the dialyzer 250; a metering drug section. The metering drug section may comprise the metering port 261 , 262, 263, and the drug pump 264 (if any) configured to be fluidly connected to the circuit reservoir 230; a draining pump section. The draining pump section may comprise the draining pump to be fluidly connected to the outlet line 220; a control section. The control section may comprise the control unit 150 and any auxiliary control element such as positioning device 154 (if any), communication device 153 (if any), and a user interface (if any). The above described sections may be stored separately and mounted to the system frame 400 to produce an organ transport system 100 according to any of the examples described herein. The sections may be sterilized and ready for use. Therefore, system 1 may be easily stored and transported before use.

[0163] Figure 15 is a flow chart schematically illustrating a method 600 for operating an organ transport system according to an example of the present disclosure. The methods 600 may be performed using organ transport systems 100 according to any of the examples disclosed herein.

[0164] The methods according to the present disclosure are intended to be applied to organs and / or tissues that are not returned to the body of the donor.

[0165] The method 600 for operating the organ transport system 100 comprises: circulating 610 the perfusion fluid 231 through the fluid circuit 200, wherein the fluid circuit 200 is configured to feed the perfusion fluid to the organ 1. providing 620 the receptacle 300 configured to receive the organ 1 , wherein the receptacle comprises a base 310 and side walls 320 defining the receiving cavity 330. The base 310 is configured to deform when supporting the organ 1 to accommodate the shape of at least a portion of the organ.

[0166] In an example, system 100 comprises the sensor 290 to sense parameters of the perfusion fluid and / or organ, the sensor being in data communication with the control unit or the remote-control station. The sensor 290 may comprise a plurality of sensors as disclosed herein. The method 600 may comprise receiving sensing data, by the control unit 150 or remote-control station 160; and determining, by the control unit 150 or remote-control station 160, whether the received sensing data comprise sensing value above or below a predetermined threshold sensing value.

[0167] In examples of method 600, the sensing data may comprise at least one of hematocrit in the perfusion fluid, hemoglobin in the perfusion fluid, oxygen saturation in the perfusion fluid, pH in the perfusion fluid, oxygen partial pressure, partial pressure of CO2, bicarbonate level, and potassium level.

[0168] The method 600 may comprise computing, by the control unit or the remote-control station, a duration of the perfusion based on initial values and target values of the parameters related to the perfusion. The duration may be obtained in order to provide a smooth gradient between the initial values and the target values. The user may introduce values of parameters to compensate for defects of the graft in order to recover the organ for transplant.

[0169] In one example, the method 600 may comprise triggering, by the control unit 150 or the remote-control station 160, an alarm signal when the sensing value is above or below a predetermined threshold sensing value.

[0170] The method 600 may further comprise producing, by the control unit or the remotecontrol station, the alarm signal including an alarm parameter.

[0171] In some examples, the method may comprise determining, by the control unit or the remote-control station, the organ state index based at least on the alarm parameters. The method may further comprise determining, by the control unit or the remote-control station, the organ state index considering donor data. Donor data may be taken into account to obtain the organ state index. The donor data may be processed as figures that have predetermined weights.

[0172] In examples, the method 600 may comprise controlling, by the control unit or remotecontrol station, the operation of the driving pump based on the pressure sensing data and flow sensing data of the perfusion fluid in the inlet line.

[0173] In examples in which the system 100 comprises a gall connection configured to be fluidly connected to a gallbladder of a liver to be transported, and a bile flow sensor associated with the gall connection to sense the bile of the transported liver, the method 600 may comprise receiving bile sensing data, and determining whether the received bile sensing data comprise bile sensing value above or below a predetermined threshold bile sensing value.

[0174] In examples in which the system 100 comprises a ureter connection that is configured to be in fluid connection with the kidney ureter and to the circuit reservoir, and a urine flow meter associated with the ureter connection and configured to sense a urine flow rate, the method 600 may comprise receiving urine sensing data, and determining whether the received urine sensing data comprise urine sensing value above or below a predetermined threshold urine sensing value.

[0175] In an example, the system 100 comprises at least one of a temperature sensor, an inlet pressure sensor, a flowmeter, a pH sensor, an oxygen sensor, a glucose sensor, a lactate sensor, or a combination thereof, and the method 600 may comprise receiving data, by the control unit 150 or the remote-control station 160, from the sensor 290, and processing, by the control unit 150, the data received from the sensor 290 to command components of the system 100.

[0176] In some examples, wherein the system comprises the positioning device 154 in data communication with the control unit 150, the method 600 may comprise correlating, by the control unit 150 or the remote-control station 160, the organ state index and positioning data.

[0177] In examples in which the system 100 comprises a positioning device in data communication with the control unit, and / or the remote-control station, the method 600 may comprise correlating, by the control unit or remote-control station, the received sensing data and positioning data from the positioning device. The correlation may be linked to the output of the transplantation, for example the success of the transplantation.

[0178] The method 600 may further comprise receiving, by the control unit or the remotecontrol station, coordinates of the donor site and the coordinates of the transplant site; receiving, by the control unit or the remote-control station, positioning data of the system 100; and calculating or computing an expected duration of transportation. The duration of the transportation may comprise a period between the organ is obtained from the donor and the point when the organ is available at the transplant site. The method 600 may comprise calculating by the control unit or the remote-control station, the estimated duration left. The duration left may comprise the expected length between the actual location of system 100 and the transplant site.

[0179] The method 600 may comprise producing, by the control unit or the remote-control station, an estimated organ state index at the transplant site based on the organ state index, the estimated transportation duration left. In examples, the method may further comprise producing, by the control unit or the remote-control station, an indication to select an alternative destination. This may occur if the estimated organ state index is lower or greater than an organ state index threshold.

[0180] In some cases, the method comprises receiving, by the control unit or the remotecontrol station, coordinates of a plurality of suitable destinations. The coordinates of the plurality of suitable destinations and the estimated organ state index may be processed to produce at least one alternative transplant site.

[0181] A training method for training an artificial intelligence approach or engine may comprise providing organ state index, transplant sites, estimated transportation duration left and associating estimated organ state index label. In some cases, the training method may further comprise associating alternative destination labels.

[0182] In some examples, wherein the sensor comprises a temperature sensor, the method 600 may comprise: setting, by the control unit 150 or remote-control station 160, a temperature target value of the perfusion fluid to be fed to the organ; receiving temperature data, by the control unit 150 or remote-control station 160, of the perfusion fluid; determining, by the control unit 150 or remote-control station 160, a duration and heat power to be applied by the heat exchanger to achieve the temperature target value; commanding, by the control unit 150 or remote-control station 160, the heat exchanger to adjust the temperature of the perfusion fluid.

[0183] In some examples in which the sensor 290 comprises an inlet pressure sensor, the method 600 may comprise: setting, by the control unit 150 or remote-control station 160, a pressure target value of the perfusion fluid to be fed to the organ; receiving pressure data, by the control unit 150 or remote-control station 160, of the perfusion fluid; determining, by the control unit 150 or remote-control station 160, the speed value of the driving pump to achieve the pressure target value; commanding, by the control unit 150 or remote-control station 160, the driving pump to adjust the pressure of the perfusion fluid.

[0184] In an example, when the system 100 comprises a drug pump 264 configured to provide the metering port with fluid media, the method 600 may comprise: setting, by the control unit 150 or remote-control station 160, a drug concentration target value to be fed to the perfusion fluid; determining, by the control unit 150 or remote-control station 160, the speed value of the drug pump 264 to achieve the drug concentration target value; commanding, by the control unit 150 or remote-control station 160, the drug pump 264 to adjust the drug concentration value.

[0185] In examples, in which the system 100 comprises the pressure actuator 500 configured to apply pressure to a first target region of the base, and configured to move relative to the base to apply pressure to a second target region different from the first target region, the method 600 may comprise setting duration and speed of the rotating movement of the pressure actuator 500.

[0186] In some examples, the method 600 may comprise at least one of: a method for performing hemodynamic control, a method for controlling the temperature of perfusion fluid, a method for controlling flow rate of the drug pump, and a method for controlling the operation of the pressure actuator. These methods may be implemented using a system 100 according to any of the examples disclosed herein.

[0187] According to an example, a method for performing hemodynamic control may comprise: receiving, by the control unit 150 or the remote-control station 160, pressure data from the inlet pressure sensor. The inlet pressure sensor may be arranged about the end of the inlet line, before a connection point with the organ; comparing, by the control unit 150 or the remote-control station 160, pressure data with a pressure data threshold. The pressure data threshold may be a predetermined pressure target value that may be received by the control unit 150. In some examples, the predetermined pressure target value may be within the range of about 50 - 100 mmHg, for instance 60 mm Hg, for the inlet line to be connected to the hepatic artery and within the range of about 8 - 10 mmHg, for instance, 8 mmHg, for the inlet line to be connected to the portal vein; determining, by the control unit 150 or the remote-control station 160, an operation parameter of the driving pump based on the comparison of received pressure data and the pressure data threshold; commanding, by the control unit 150 or the remote-control station 160, the driving pump to drive the perfusion fluid at the predetermined pressure target value. If the driving pump comprises a pump based on rotation, the control unit may determine a target speed value to set the rotation of the pump. The speed of the pump may be the operation parameter.

[0188] In some examples, a method for controlling temperature of perfusion fluid may comprise: receiving, by the control unit 150 or the remote-control station 160, a target temperature value of the perfusion fluid. The target temperature value may be received from the remote-control station 160, a display of the user interface, or may be a predetermined temperature value; receiving, by the control unit 150 or the remote-control station 160, temperature data from the temperature sensor. The temperature sensor may be arranged associated with the inlet line and / or the receiving cavity 330; comparing, by the control unit 150 or the remote-control station 160, temperature data with target temperature value; determining, by the control unit 150, an increase in temperature of the perfusion fluid over a predetermined period. For instance, temperature may be increased one degree per minute, if there is a difference of degrees between the temperature data and the target temperature value, the control unit may determine that every minute the temperature is increased by one degree during five minutes; commanding, by the control unit 150 or the remote-control station 160, the heat exchanger to set the temperature of the perfusion fluid over the predetermined period.

[0189] In some examples, a method for controlling the flow rate of the drug pump may comprise: receiving, by the control unit or remote-control station 160, a fluid media flow rate value of the fluid media to circuit reservoir 230. The fluid media flow rate may be predetermined, or received through the user interface or the remote-control station; setting, by the control unit or remote-control station 160, an operation parameter of the drug pump; commanding, by the control unit or remote-control station 160, the drug pump to provide the fluid media to the fluid circuit.

[0190] In some examples, a method for controlling the operation of the pressure actuator may comprise: receiving, by the control unit or remote-control station 160, a duration value of the operation of the pressure actuator, and intensity value; commanding, by the control unit or remote-control station 160, the pressure actuator to operate the pressure actuator based on the duration value and a speed of the rotor of the pressure actuator based on the intensity value.

[0191] According to an aspect, a remote-control station 160 is disclosed. The remote-control station 160 is configured to be in data communication with the control unit 150 of an organ transport system according to any of the examples disclosed herein.

[0192] The remote-control station 160 may be configured to perform an analysis data method. The analysis data method may comprise: performing the method 600 according to any of the examples disclosed herein; obtaining overall data generated from method 600. This feature may comprise receiving and storing the generated overall data; comparing overall data with overall data thresholds to detect deviations; determining a viability parameter based on detected deviations and success of transplantation output.

[0193] According to a further aspect, a receptacle 300 to be held by an organ transport system 100 according to any of the examples disclosed herein, is disclosed.

[0194] In some cases, the organ transport system 100 comprises the fluid circuit 200 for circulating the perfusion fluid to be fed to the organ, and the receptacle 300 configured to receive the organ. The receptacle comprises the base 310 and side walls 320 that define the receiving cavity 330, and the base being deformable, as disclosed herein. This example of organ transport system 100 may be used to implement any method or device according to any of the examples disclosed herein.

[0195] In some further cases, the organ transport system 100 comprises the fluid circuit 200 for circulating the perfusion fluid to be fed to the organ, and the receptacle 300 configured to receive the organ. The receptacle comprises the base 310 and side walls 320 that define the receiving cavity 330. The base being configured to deform, wherein the base is able to substantially vary, at least partially, its general shape by applying pressure thereto. This example of organ transport system 100 may be used to implement any method or device according to any of the examples disclosed herein.

[0196] According to a yet further aspect, a perfusion fluid to be fed to an organ held by an organ transport system 100 according to any of examples disclosed herein.

[0197] The perfusion fluid may comprise a solution. The perfusion fluid may comprise a normothermic perfusion solution that is suitable for performing normothermic perfusion, for example at about 37 degrees Celsius. In examples, the perfusion fluid may comprise a hypothermic perfusion solution that is suitable for hypothermic perfusion, for example at about 4 degrees Celsius.

[0198] Normothermic perfusion solution for liver

[0199] In one example, the normothermic perfusion solution may comprise a normothermic liver perfusion solution. The normothermic liver perfusion solution may comprise:

[0200] Blood. Blood may comprise a haematocrit in the range of approximately 25% - 45%.

[0201] Human albumin. Human albumin may be used to maintain adequate oncotic pressure during infusion. The human albumin used may have a concentration of 50 g / l.

[0202] Heparin. Heparin may help prevent or at least reduce clot formation. The heparin used may have a concentration of 1000 lll / ml.

[0203] Calcium chloride. Calcium chloride may have a concentration of 100 mg / ml.

[0204] Sodium bicarbonate. Bicarbonate may help to control the pH level of the liver, e.g. below 7.3.

[0205] Antibiotic. In one example, the antibiotic may be cefoxitin 1g and / or metronidazole 500 mg.

[0206] Plasma volume surrogate. For example, Gelaspan tm. The plasma volume surrogate may be used in the case where the human blood volume is below a minimum threshold value for proper functioning of the fluid circuit and organ perfusion.

[0207] The above example of a normothermic perfusion solution may be used in an initial perfusion to the organ, e.g. liver. That is, the composition used to initiate perfusion of the organ.

[0208] In some examples, the normothermic perfusion solution may further comprise at least one of:

[0209] Liver nutrition solution. This solution may comprise insulin, vitamins, and / or trace elements. In some cases, fat-free parenteral nutrition products such as Smofkaviben tm may be included. Insulin may have a concentration of 100 lll / ml.

[0210] Taurocholic acid. Taurocholic acid may stimulate bile secretion. Taurocholic acid solution may be more than 98% pure.

[0211] Epoprosterenol. This is a prostaglandin that may prevent platelet formation and aggregation in connection with blood clotting and may be suitable for arterial vasodilation.

[0212] Glucose. This may be added if the glucose levels of the normothermic perfusion solution fall below a threshold value, e.g. 10 mmol / l. These elements may be incorporated into the above example of initial perfusion at the start of perfusion or later over time. Each element may be incorporated at a different time, or some may be incorporated together.

[0213] In the case of hypothermic liver perfusion, for example, one of the following solutions may be used:

[0214] HTK Solution

[0215] IGL-2 Solution

[0216] Belzer Solution solution for ki

[0217] In one example, the normothermic perfusion solution may comprise a normothermic kidney perfusion solution. The normothermic kidney perfusion solution may comprise:

[0218] Plasmalite tm solution. This solution may comprise sodium chloride, potassium chloride, magnesium chloride hexahydrate, sodium acetate trihydrate, and sodium gluconate.

[0219] Red blood cell concentrate.

[0220] Mannitol. Mannitol may be used to prevent cellular oedema.

[0221] Dexamethasone. This product is a corticosteroid that can prevent inflammation and promote the generation of adenosine triphosphate (ATP). Dexamethasone can have a concentration of 4 mb / ml.

[0222] Heparin. Heparin may prevent thrombosis and promote stability of the vascular endothelium. The heparin used may have a concentration of 1000 lll / ml.

[0223] Sodium bicarbonate. Bicarbonate may help control the pH level of the kidney, e.g. 7.3 - 7.4.

[0224] Antibiotic. For example, Cefoxitin 2g.

[0225] The above example of a normothermic perfusion solution may be used in an initial perfusion to the organ, e.g. kidney. That is, the composition used to initiate perfusion of the organ.

[0226] In some examples, the normothermic perfusion solution may further comprise at least one of:

[0227] Kidney nutrition solution. This solution may comprise Lipoflex tm, insulin, sodium bicarbonate, and vitamins. Lipoflex tm may include fluid, amino acids, electrolytes, and fatty acids that may be suitable for kidney growth or recovery. Lipoflex tm may also include carbohydrates and fats.

[0228] Glucose.

[0229] Epoprosterenol. This is a prostaglandin that may prevent platelet formation and aggregation in connection with blood clotting and may be suitable for arterial vasodilation.

[0230] In the case of hypothermic perfusion of the kidney, for example, one of the following solutions may be used:

[0231] Aqueous solution with a mixture of electrolytes and amino acids. For example, Custodiol tm may be used with a flow rate of 100 - 150 ml / min.

[0232] Belzer Solution

[0233] The normothermic liver perfusion solution described in the initial perfusion example can be provided to the receptacle 300. The volume of normothermic liver perfusion solution depends on the circumstances. The volume of solution can be chosen to achieve priming of the fluid circuit 200 and to avoid as far as possible the occurrence of bubbles in the fluid circuit 200. The flow rate through the fluid circuit 200 depends on the weight of the liver and the appropriate pressure in the hepatic artery, for example 80 / 40 mmHg, and the portal vein, for example 8 mmHg.

[0234] For reasons of completeness, various aspects of the present disclosure are set out in the following numbered clauses:

[0235] Clause 1. An organ transport system comprising: a fluid circuit for circulating a perfusion fluid to be fed to an organ; a receptacle configured to receive the organ, wherein the receptacle comprises a base and side walls defining a receiving cavity, the base being configured to deform, at least partially, when supporting the organ to accommodate the shape of at least a portion of the organ.

[0236] Clause 2. The system according to clause 1 , wherein the base comprises a thinner cross section than the cross section of at least a part of the side wall.

[0237] Clause 3. The system according to any of clauses 1 - 2, wherein the base is made from a different material from at least a part of the side wall.

[0238] Clause 4. The system according to any of clauses 1 - 3, wherein the base comprises a deformable supporting region to accommodate the organ.

[0239] Clause 5. The system according to clauses 2 and 4, wherein the deformable supporting region comprises a thinner cross section than the cross section of at least a part of the side wall.

[0240] Clause 6. The system according to clauses 3 and 4, wherein the deformable supporting region is made from a different material from at least a part of the side wall.

[0241] Clause 7. The system according to clause 6, wherein the deformable supporting region is made from a more flexible material than at least a part of the side wall.

[0242] Clause 8. The system according to any of clauses 1 - 7, wherein a side wall comprise a side lower portion connected to the base and an upper side portion.

[0243] Clause 9. The system according to clauses 4 and 8, wherein the deformable supporting region comprises a thinner cross section than the cross section of the upper side portion.

[0244] Clause 10. The system according to clauses 4 and 8, wherein the deformable supporting region is made from a different material from the upper side portion.

[0245] Clause 11. The system according to clause 10, wherein the deformable supporting region is made from a more flexible material than the upper side portion.

[0246] Clause 12. The system according to any of clauses 1 - 11 , comprising a holding edge to hold or support the receptacle.

[0247] Clause 13. The system according to any of clauses 1 - 12, comprising: a system frame configured to support the fluid circuit and the receptacle.

[0248] Clause 14. The system according to clause 13, comprising: a receptacle holding structure to hold the receptacle, wherein the receptacle holding structure is releasably attached to the system frame.

[0249] Clause 15. The system according to any of clauses 8 and 14, wherein the upper side portion of the side wall is configured to be releasably attached to the receptacle holding structure.

[0250] Clause 16. The system according to clause 15, wherein the upper side portion comprises a holding edge configured to be releasably attached to the receptacle holding structure.

[0251] Clause 17. The system according to clause 16, wherein the holding edge comprises a retention tab to releasably retain the holding edge with respect to the receptacle holding structure.

[0252] Clause 18. The system according to any of clauses 14 - 17, wherein the receptacle holding structure comprises a vertical adjusting device to adjust a vertical position of the receptacle relative to the system frame.

[0253] Clause 19. The system according to clause 4, wherein the deformable supporting region extends only along a part of the base.

[0254] Clause 20. The system according to any of clauses 1 - 19, wherein the receptacle is made from a biocompatible material.

[0255] Clause 21. The system according to clause 20, wherein the receptacle is made from a medical-grade polymer.

[0256] Clause 22. The system according to any of clauses 20 - 21 , wherein the receptacle is made from silicone. Clause 23. The system according to any of clauses 1 - 22, wherein the receptacle comprises a lid.

[0257] Clause 24. The system according to clause 23, wherein the lid comprises a control window.

[0258] Clause 25. The system according to clause 24, wherein the control window is made from a transparent material.

[0259] Clause 26. The system according to clause 4, wherein the deformable supporting region comprises a plate-like configuration, and the base comprises a draining channel between the deformable supporting region and at least a lateral wall, wherein an angle is defined between the deformable supporting region and the direction of the path of the draining channel.

[0260] Clause 27. The system according to clause 26, wherein the draining channel is arranged among the deformable supporting region and at least a pair of the side walls so that the draining channel is arranged with respect to at least a part of the perimeter of the deformable supporting region.

[0261] Clause 28. The system according to any of clauses 26 - 27, the receptacle comprises a draining hole arranged in the draining channel.

[0262] Clause 29. The system according to clause 28, wherein the fluid circuit comprises a draining pump in fluid communication with the draining hole.

[0263] Clause 30. The system according to clause 4, wherein the deformable supporting region comprises a fluid-tight configuration.

[0264] Clause 31. The system according to any of clauses 1 - 30, comprising a gall connection configured to be fluidly connected to the gallbladder of the organ, wherein the gall connection is fluidly connected to a gall reservoir.

[0265] Clause 32. The system according to any of clauses 1 - 31 , wherein the organ comprises a liver and / or a kidney.

[0266] Clause 33. The system according to any of clauses 1 - 32, wherein the fluid circuit comprises a ureter connection configured to be fluidly connected to a ureter of the organ and to a circuit reservoir of the fluid circuit.

[0267] Clause 34. The system according to any of clauses 1 - 33, wherein the fluid circuit comprises at least one inlet line to be fluidly connected to a blood vessel of the organ to supply perfusion fluid to the organ.

[0268] Clause 35. The system according to any of clauses 1 - 34, wherein the fluid circuit comprises at least an outlet line to be fluidly connected to the receiving cavity and / or the organ to receive at least perfusion fluid.

[0269] Clause 36. The system according to clause 34, wherein the fluid circuit comprises a first inlet line to be fluidly connected to a hepatic artery to supply perfusion fluid, and a second inlet line to be fluidly connected to a hepatic portal vein to supply perfusion fluid.

[0270] Clause 37. The system according to clause 34, wherein the fluid circuit comprises a first inlet line to be fluidly connected to a renal artery to supply perfusion fluid.

[0271] Clause 38. The system according to clauses 28 and 35, wherein the fluid circuit comprises a first outlet line to be fluidly connected to the draining hole.

[0272] Clause 39. The system according to clause 35, wherein the fluid circuit comprises a second outlet line to be fluidly connected to the renal vein to receive at least perfusion fluid from the organ, wherein the second outlet line is fluidly connected to a circuit reservoir of the fluid circuit.

[0273] Clause 40. The system according to any of clauses 1 - 39, wherein the fluid circuit comprises a driving pump to drive perfusion fluid from a circuit reservoir.

[0274] Clause 41. The system according to any of clauses 1 - 40, wherein the fluid circuit comprises a draining pump to drive perfusion fluid to a circuit reservoir.

[0275] Clause 42. The system according to clauses 36 and 40, wherein the first inlet line comprises a first driving pump to drive perfusion fluid from the circuit reservoir.

[0276] Clause 43. The system according to clauses 36 and 40, wherein the fluid circuit comprises a first driving pump, and the second inlet line comprises a second driving pump.

[0277] Clause 44. The system according to clause 34, wherein the inlet line comprises an oxygenator to provide the perfusion fluid with oxygen.

[0278] Clause 45. The system according to clause 34, wherein the inlet line comprises a heat exchanger.

[0279] Clause 46. The system according to clause 34, wherein the inlet line comprises a bubble trap.

[0280] Clause 47. The system according to clause 34, wherein the inlet line comprises a drainage valve.

[0281] Clause 48. The system according to clause 35, wherein the outlet line comprises a dialyzer.

[0282] Clause 49. The system according to any of clauses 1 - 48, wherein the fluid circuit comprises a metering port configured to receive a fluid media.

[0283] Clause 50. The system according to any of clauses 34 - 35, wherein the receptacle comprises an entrance port and / or an exit port arranged in the side wall, wherein the entrance port and / or the exit port are configured to be received, at least partially, an inlet line and / or and outlet line.

[0284] Clause 51. The system according to any of clauses 1 - 50, comprising a pressure actuator configured to apply pressure to a first target region of the base, wherein the pressure actuator is configured to move relative to the base to apply pressure to a second target region different from the first target region.

[0285] Clause 52. The system according to clause 51 , wherein the pressure actuator comprises a protrusion extending from a rotor, wherein the protrusion is configured to extend to the base, wherein the protrusion is arranged in an off-centre position with respect to a rotation axis of the rotor.

[0286] Clause 53. The system according to clause 52, wherein the pressure actuator comprises a plurality of protrusions arranged in off-centre positions with respect to the rotation axis.

[0287] Clause 54. The system according to any of clauses 51 - 53, comprising a plurality of pressure actuators.

[0288] Clause 55. The system according to clause 51 , wherein the base is arranged between at least the pressure actuator and the receiving cavity.

[0289] Clause 56. The system according to any of clauses 51 - 55, comprising a pad between the pressure actuator and the base.

[0290] Clause 57. The system according to any of clauses 1 - 56, comprising a control unit.

[0291] Clause 58. The system according to any of clauses 1 - 57, wherein the fluid circuit comprises at least one of a temperature sensor, an inlet pressure sensor, a flowmeter, a pH sensor, an oxygen sensor, a glucose sensor, a lactate sensor, or a combination thereof.

[0292] Clause 59. The system according to clauses 57 and 58, wherein the control unit is configured to: receive sensing data; determine whether the received sensing data comprise sensing value above or below a predetermined threshold sensing value.

[0293] Clause 60. The system according to clause 59, wherein the sensing data comprises at least one of hematocrit in the perfusion fluid, hemoglobin in the perfusion fluid, oxygen saturation in the perfusion fluid, pH in the perfusion fluid, oxygen partial pressure, partial pressure of CO2, bicarbonate level, potassium level.

[0294] Clause 61. The system according to any of clauses 59 - 60, wherein the control unit is configured to: trigger an alarm signal when the sensing value is above or below a predetermined threshold sensing value.

[0295] Clause 62. The system according to clause 61 , wherein the control unit is configured to: produce the alarm signal including at least one alarm parameter.

[0296] Clause 63. The system according to clause 62, wherein the control unit is configured to: determine an organ state index based at least on the alarm parameter.

[0297] Clause 64. The system according to clause 63, wherein the organ state index comprises an organ viability index.

[0298] Clause 65. The system according to any of clauses 61 - 64, wherein the alarm parameters comprise timing, duration, and kind of the alarm signal.

[0299] Clause 66. The system according to any of clauses 62 - 65, wherein the organ state index is determined considering donor data.

[0300] Clause 67. The system according to clause 57, comprising a positioning device in data communication with the control unit.

[0301] Clause 68. The system according to clause 67, wherein the positioning device comprises a positioning transmitter and / or a positioning receiver.

[0302] Clause 69. The system according to clause 68, comprising a communication device in data communication with the control unit, wherein the control unit is configured to establish a data communication with a remote control station through the communication device.

[0303] Clause 70. The system according to clause 69, wherein the control unit is configured to be remotely operated from the remote control station.

[0304] Clause 71. The system according to clauses 62 and 68, wherein the control unit is configured to correlate the organ state index and positioning data.

[0305] Clause 72. The system according to clause 62, comprising a user interface in data communication with the control unit.

[0306] Clause 73. The system according to clause 72, wherein the control unit is configured to: receive user input comprising initial values and target values of parameters related to the perfusion process over a predetermined period; compute a duration of the perfusion process based on the initial values and target values.

[0307] Clause 74. The system according to clause 67, wherein the control unit is configured to: receive coordinates of the donor site and the coordinates of the transplant site; calculate an expected duration of transportation.

[0308] Clause 75. The system according to any of clauses 1 - 74, comprising a battery to feed electric devices with power.

[0309] Clause 76. The system according to any of clauses 1 - 75, wherein the system frame comprises wheels to move the system.

[0310] Clause 77. An organ transport system comprising: a fluid circuit for circulating a perfusion fluid to be fed to an organ; a receptacle configured to receive the organ, wherein the receptacle comprises a base and side walls defining a receiving cavity, the base being deformable.

[0311] Clause 78. An organ transport system comprising: a fluid circuit for circulating a perfusion fluid to be fed to an organ; a receptacle configured to receive the organ, wherein the receptacle comprises a base and side walls defining a receiving cavity, the base being configured to deform, wherein the base is able to substantially vary, at least partially, its general shape by applying pressure thereto.

[0312] Clause 79. A remote-control station configured to be in data communication with the control unit of an organ transport system according to clause 70.

[0313] Clause 80. A method for operating an organ transport system comprising: circulating a perfusion fluid through a fluid circuit, wherein the fluid circuit is configured to feed the perfusion fluid to the organ; providing a receptacle configured to receive an organ, wherein the receptacle comprises a base and side walls defining a receiving cavity, the base being configured to deform at least partially when supporting the organ to accommodate the shape of at least a portion of the organ.

[0314] Clause 81. The method according to clause 80, wherein the system comprises a sensor to sense parameters of the perfusion fluid and / or organ, the sensor being in data communication with the control unit or the remote-control station, wherein the method comprises: receiving sensing data, by the control unit or remote-control station; determining, by the control unit or remote-control station, whether the received sensing data comprise a sensing value above or below a predetermined threshold sensing value.

[0315] Clause 82. The method according to clause 81 , wherein the system comprises at least one of a temperature sensor, a pressure sensor, a flowmeter, a pH sensor, an oxygen sensor, a glucose sensor, a lactate sensor, or a combination thereof.

[0316] Clause 83. The method according to any of clauses 81 - 82, wherein the sensing data comprises at least one of hematocrit in the perfusion fluid, hemoglobin in the perfusion fluid, oxygen saturation in the perfusion fluid, pH in the perfusion fluid, oxygen partial pressure, partial pressure of CO2, bicarbonate level, potassium level.

[0317] Clause 84. The method according to any of clauses 81 - 83, comprising: triggering, by the control unit or the remote-control station, an alarm signal when the sensing value is above or below a predetermined threshold sensing value.

[0318] Clause 85. The method according to clause 84, comprising: producing, by the control unit or the remote-control station, the alarm signal including an alarm parameter.

[0319] Clause 86. The method according to clause 85, comprising: determining, by the control unit or the remote-control station, an organ state index based at least on the alarm parameter.

[0320] Clause 87. The method according to clause 86, wherein the organ state index comprises an organ viability index.

[0321] Clause 88. The method according to any of clauses 85 - 87, wherein the alarm parameters comprise timing, duration, and kind of the alarm signal. Clause 89. The method according to any of clauses 84 - 88, wherein the organ state index is determined considering donor data.

[0322] Clause 90. The method according to any of clauses 81 - 89, wherein the system comprises a driving pump to drive perfusion fluid from a circuit reservoir, and the sensor comprises a pressure sensor to sense pressure of the perfusion fluid in the inlet line, and a flowmeter to sense flow rate in the inlet line, wherein the method comprises: controlling, by the control unit or remote-control station, the operation of the driving pump based on the pressure sensing data and flow sensing data of the perfusion fluid in the inlet line.

[0323] Clause 91. The method according to any of clauses 80 - 90, wherein the system comprises a gall connection configured to be fluidly connected to a gallbladder of a liver to be transported, and a bile flow sensor associated with the gall connection to sense the bile of the transported liver, wherein the method comprises: receiving bile sensing data, and determining whether the received bile sensing data comprise bile sensing value above or below a predetermined threshold bile sensing value.

[0324] Clause 92. The method according to any of clauses 80 - 90, wherein the system comprises a ureter connection that is configured to be in fluid connection with the kidney ureter and to the circuit reservoir, and a urine flow meter associated with the ureter connection and configured to sense a urine flow rate, wherein the method comprises: receiving urine sensing data, and determining whether the received urine sensing data comprise urine sensing value above or below a predetermined threshold urine sensing value.

[0325] Clause 93. The method according to any of clauses 80 - 92, wherein the system comprises a positioning device in data communication with the control unit, and / or the remote-control station, wherein the method comprises: correlating, by the control unit or remote-control station, the received sensing data and positioning data from the positioning device.

[0326] Clause 94. The method according to any of clauses 80 - 93, comprising: receiving, by the control unit or remote-control station, user input comprising initial values and target values of parameters related to the perfusion process over a predetermined period; computing, by the control unit or remote-control station, a duration of the perfusion process based on the initial values and target values.

[0327] Clause 95. The method according to any of clauses 80 - 94, comprising: receiving, by the control unit or remote-control station, coordinates of the donor site and the coordinates of the transplant site; calculating, by the control unit or remote-control station, an expected duration of transportation.

[0328] Clause 96. The method according to any of clauses 80 - 95, wherein the sensor comprises a temperature sensor, the method comprising: setting, by the control unit or remote-control station, a temperature target value of the perfusion fluid to be fed to the organ; receiving temperature data, by the control unit or remote-control station, of the perfusion fluid; determining, by the control unit or remote-control station, a duration and heat power to be applied by the heat exchanger to achieve the temperature target value; commanding, by the control unit or remote-control station, the heat exchanger to adjust the temperature of the perfusion fluid.

[0329] Clause 97. The method according to any of clauses 80 - 96, wherein the sensor comprises a pressure sensor, the method comprising: setting, by the control unit or remote-control station, a pressure target value of the perfusion fluid to be fed to the organ; receiving pressure data, by the control unit or remote-control station, of the perfusion fluid; determining, by the control unit or remote-control station, speed value of the driving pump to achieve the pressure target value; commanding, by the control unit or remote-control station, the driving pump to adjust the pressure of the perfusion fluid.

[0330] Clause 98. The method according to any of clauses 80 - 97, wherein the system comprises a drug pump to provide the metering port with fluid media, a drug sensor in data communication with the control unit or the remote control unit, the drug sensor being associated with the fluid circuit to sense a drug concentration value of the perfusion fluid, the method comprising: setting, by the control unit or remote-control station, a drug concentration target value to be fed to the perfusion fluid; receiving, by the control unit or remote-control station, the drug concentration target value; determining, by the control unit or remote-control station, speed value of the drug pump to achieve the drug concentration target value; commanding, by the control unit or remote-control station, the drug pump to adjust the drug concentration value.

[0331] Clause 99. The method according to any of clauses 80 - 98, wherein the system comprises a pressure actuator configured to apply pressure to a first target region of the base, wherein the pressure actuator is configured to move relative to the base to apply pressure to a second target region different from the first target region; wherein the method comprises: setting duration and speed, by the control unit or remote-control station, of a rotating movement of the pressure actuator.

[0332] Clause 100. A perfusion fluid to be fed to an organ held by an organ transport system according to any of clauses 1 - 78.

[0333] Clause 101 . A receptacle to be held by an organ transport system according to any of clauses 1 - 78.

[0334] Clause 102. An organ transport system comprising a system frame according to any of the previous clauses, a receptacle according to any of the previous clauses, and a plurality of functional sections.

[0335] Clause 103. The system according to clause 102, wherein the functional sections comprise a fluid circuit section, a sensor section, a ureter section, a dialyzer section, a metering drug section, a draining pump section, and a control section.

[0336] Clause 104. A method for treating an organ ex vivo, using an organ transport system according to any of the examples disclosed herein, the method comprising: providing the organ in the receptacle, connecting the organ to the fluid circuit; receiving, by the control unit, initial values of the parameters of a perfusion process to be applied to the organ; receiving, by the control unit, target values of the parameters of the perfusion process to be applied to the organ.

[0337] Clause 105. The method according to clause 104, comprising: calculating, by the control unit, an estimated duration of the perfusion process based at least on the initial values and the target values.

[0338] Clause 106. The method according to any of clauses 104 - 105, comprising: computing, by the control unit, intermediate values of the parameters between the initial values and the target values.

[0339] Clause 107. The method according to any of clauses 104 - 106, comprising: commanding, by the control unit, a pressure actuator.

[0340] Clause 108. The method according to clause 107, comprising: setting duration and speed, by the control unit, of a rotating movement of the pressure actuator

[0341] Although only a number of examples have been disclosed herein, other alternatives, modifications, uses and / or equivalents thereof are possible. Furthermore, all possible combinations of the described examples are also covered. Thus, the scope of the present disclosure should not be limited by particular examples, but should be determined only by a fair reading of the claims that follow. If reference signs related to drawings are placed in parentheses in a claim, they are solely for attempting to increase the intelligibility of the claim, and shall not be construed as limiting the scope of the claim.

Claims

CLAIMS1 . An organ transport system comprising: a fluid circuit for circulating a perfusion fluid to be fed to an organ; a receptacle configured to receive the organ, wherein the receptacle comprises a base and side walls defining a receiving cavity, the base being able to substantially vary, at least partially, its general shape by applying pressure to the base, the base being configured to deform, at least partially, when supporting the organ to accommodate the shape of at least a portion of the organ; wherein the base comprises a deformable supporting region to accommodate the organ; wherein the deformable supporting region comprises a plate-like configuration, and the base comprises a draining channel between the deformable supporting region and at least a lateral wall, wherein an angle is defined between the deformable supporting region and the direction of the path of the draining channel.

2. The system according to claims 1 , wherein the base comprises a thinner cross section than the cross section of at least a part of the side wall.

3. The system according to any of claims 1 — 2, wherein the base is made from a different material from at least a part of the side wall.

4. The system according to claim 2, wherein the deformable supporting region comprises a thinner cross section than the cross section of at least a part of the side wall.

5. The system according to claim 3, wherein the deformable supporting region is made from a different material from at least a part of the side wall.

6. The system according to claim 5, wherein the deformable supporting region is made from a more flexible material than at least a part of the side wall.

7. The system according to any of claims 1 - 6, wherein a side wall comprise a side lower portion connected to the base and an upper side portion.

8. The system according to claim 7, wherein the deformable supporting region comprises a thinner cross section than the cross section of the upper side portion.

9. The system according to claim 7, wherein the deformable supporting region is made from a different material from the upper side portion.

10. The system according to claim 9, wherein the deformable supporting region is made from a more flexible material than the upper side portion.

11. The system according to any of claims 1 - 10, comprising a holding edge to hold or support the receptacle.

12. The system according to any of claims 1 - 11 , comprising: a system frame configured to support the fluid circuit and the receptacle.

13. The system according to claim 12, comprising: a receptacle holding structure to hold the receptacle, wherein the receptacle holding structure is releasably attached to the system frame.

14. The system according to any of claims 7 and 13, wherein the upper side portion of the side wall is configured to be releasably attached to the receptacle holding structure.

15. The system according to claim 14, wherein the upper side portion comprises a holding edge configured to be releasably attached to the receptacle holding structure.

16. The system according to claim 13, wherein the holding edge comprises a retention tab to releasably retain the holding edge with respect to the receptacle holding structure.

17. The system according to any of claims 13 - 16, wherein the receptacle holding structure comprises a vertical adjusting device to adjust a vertical position of the receptacle relative to the system frame.

18. The system according to any of claims 1 - 17, wherein the deformable supporting region extends only along a part of the base.

19. The system according to any of claims 1 - 18, wherein the receptacle is made from a biocompatible material.

20. The system according to claim 19, wherein the receptacle is made from a medicalgrade polymer.

21. The system according to any of claims 19 - 20, wherein the receptacle is made from silicone.

22. The system according to any of claims 1 - 21 , wherein the receptacle comprises a lid.

23. The system according to claim 22, wherein the lid comprises a control window.

24. The system according to claim 23, wherein the control window is made from a transparent material.

25. The system according to claim 1 , wherein the draining channel is arranged among the deformable supporting region and at least a pair of the side walls so that the draining channel is arranged with respect to at least a part of the perimeter of the deformable supporting region.

26. The system according to any of claims 1 - 25, the receptacle comprises a draining hole arranged in the draining channel.

27. The system according to claim 26, wherein the fluid circuit comprises a draining pump in fluid communication with the draining hole.

28. The system according to claim 1 , wherein the deformable supporting region comprises a fluid-tight configuration.

29. The system according to any of claims 1 - 28, comprising a gall connection configured to be fluidly connected to the gallbladder of the organ, wherein the gall connection is fluidly connected to a gall reservoir.

30. The system according to any of claims 1 - 29, wherein the organ comprises a liver and / or a kidney.31 . The system according to any of claims 1 - 30, wherein the fluid circuit comprises a ureter connection configured to be fluidly connected to a ureter of the organ and to acircuit reservoir of the fluid circuit.

32. The system according to any of claims 1 - 31 , wherein the fluid circuit comprises at least one inlet line to be fluidly connected to a blood vessel of the organ to supply perfusion fluid to the organ.

33. The system according to any of claims 1 - 32, wherein the fluid circuit comprises at least an outlet line to be fluidly connected to the receiving cavity and / or the organ to receive at least perfusion fluid.

34. The system according to claim 32, wherein the fluid circuit comprises a first inlet line to be fluidly connected to a hepatic artery to supply perfusion fluid, and a second inlet line to be fluidly connected to a hepatic portal vein to supply perfusion fluid.

35. The system according to claim 32, wherein the fluid circuit comprises a first inlet line to be fluidly connected to a renal artery to supply perfusion fluid.

36. The system according to claims 26 and 33, wherein the fluid circuit comprises a first outlet line to be fluidly connected to the draining hole.

37. The system according to claim 33, wherein the fluid circuit comprises a second outlet line to be fluidly connected to the renal vein to receive at least perfusion fluid from the organ, wherein the second outlet line is fluidly connected to a circuit reservoir of the fluid circuit.

38. The system according to any of claims 1 - 37, wherein the fluid circuit comprises a driving pump to drive perfusion fluid from a circuit reservoir.

39. The system according to any of claims 1 - 38, wherein the fluid circuit comprises a draining pump to drive perfusion fluid to a circuit reservoir.

40. The system according to claims 34 and 38, wherein the first inlet line comprises a first driving pump to drive perfusion fluid from the circuit reservoir.

41. The system according to claims 34 and 38, wherein the fluid circuit comprises a first driving pump, and the second inlet line comprises a second driving pump.

42. The system according to claim 32, wherein the inlet line comprises an oxygenator to provide the perfusion fluid with oxygen.

43. The system according to claim 32, wherein the inlet line comprises a heat exchanger.

44. The system according to claim 32, wherein the inlet line comprises a bubble trap.

45. The system according to claim 32, wherein the inlet line comprises a drainage valve.

46. The system according to claim 33, wherein the outlet line comprises a dialyzer.

47. The system according to any of claims 1 - 46, wherein the fluid circuit comprises a metering port configured to receive a fluid media.

48. The system according to any of claims 32 - 33, wherein the receptacle comprises an entrance port and / or an exit port arranged in the side wall, wherein the entrance port and / or the exit port are configured to be received, at least partially, an inlet line and / or and outlet line.

49. The system according to any of claims 1 - 48, comprising a pressure actuator configured to apply pressure to a first target region of the base, wherein the pressure actuator is configured to move relative to the base to apply pressure to a second target region different from the first target region.

50. The system according to claim 49, wherein the pressure actuator comprises a protrusion extending from a rotor, wherein the protrusion is configured to extend to the base, wherein the protrusion is arranged in an off-centre position with respect to a rotation axis of the rotor.

51. The system according to claim 50, wherein the pressure actuator comprises a plurality of protrusions arranged in off-centre positions with respect to the rotation axis.

52. The system according to any of claims 49 - 51 , comprising a plurality of pressure actuators.

53. The system according to claim 49, wherein the base is arranged between at least the pressure actuator and the receiving cavity.

54. The system according to any of claims 49 - 53, comprising a pad between the pressure actuator and the base.

55. The system according to any of claims 1 - 54, comprising a control unit.

56. The system according to any of claims 1 - 55, wherein the fluid circuit comprises at least one of a temperature sensor, an inlet pressure sensor, a flowmeter, a pH sensor, an oxygen sensor, a glucose sensor, a lactate sensor, or a combination thereof.

57. The system according to claims 55 and 56, wherein the control unit is configured to: receive sensing data; determine whether the received sensing data comprise sensing value above or below a predetermined threshold sensing value.

58. The system according to claim 57, wherein the sensing data comprises at least one of hematocrit in the perfusion fluid, hemoglobin in the perfusion fluid, oxygen saturation in the perfusion fluid, pH in the perfusion fluid, oxygen partial pressure, partial pressure of CO2, bicarbonate level, potassium level.

59. The system according to any of claims 57 - 58, wherein the control unit is configured to: trigger an alarm signal when the sensing value is above or below a predetermined threshold sensing value.

60. The system according to claim 59, wherein the control unit is configured to: produce the alarm signal including at least one alarm parameter.

61. The system according to claim 60, wherein the control unit is configured to: determine an organ state index based at least on the alarm parameter.

62. The method according to claim 61 , wherein the organ state index comprises an organ viability index.

63. The method according to any of claims 59 - 62, wherein the alarm parameters comprise timing, duration, and kind of the alarm signal.

64. The method according to any of claims 60 - 63, wherein the organ state index is determined considering donor data.

65. The system according to claim 55, comprising a positioning device in data communication with the control unit.

66. The system according to claim 65, wherein the positioning device comprises a positioning transmitter and / or a positioning receiver.

67. The system according to claim 66, comprising a communication device in data communication with the control unit, wherein the control unit is configured to establish a data communication with a remote control station through the communication device.

68. The system according to claim 67, wherein the control unit is configured to be remotely operated from the remote control station.

69. The system according to claims 60 and 66, wherein the control unit is configured to correlate the organ state index and positioning data.

70. The system according to claim 60, comprising a user interface in data communication with the control unit.

71. The system according to claim 70, wherein the control unit is configured to: receive user input comprising initial values and target values of parameters related to the perfusion process over a predetermined period; compute a duration of the perfusion process based on the initial values and target values.

72. The system according to claim 65, wherein the control unit is configured to: receive coordinates of the donor site and the coordinates of the transplant site; calculate an expected duration of transportation.

73. The system according to any of claims 1 - 72, comprising a battery to feed electric devices with power.

74. The system according to any of claims 1 - 73, wherein the system frame comprises wheels to move the system.

75. A remote-control station configured to be in data communication with the control unit of an organ transport system according to claim 68.

76. A method for operating an organ transport system comprising: circulating a perfusion fluid through a fluid circuit, wherein the fluid circuit is configured to feed the perfusion fluid to the organ; providing a receptacle configured to receive an organ, wherein the receptacle comprises a base and side walls defining a receiving cavity, the base being able to substantially vary, at least partially, its general shape by applying pressure to the base, the base being configured to deform, at least partially, when supporting the organ to accommodate the shape of at least a portion of the organ; wherein the base comprises a deformable supporting region to accommodate the organ; wherein the deformable supporting region comprises a plate-like configuration, and the base comprises a draining channel between the deformable supporting region and at least a lateral wall, wherein an angle is defined between the deformable supporting region and the direction of the path of the draining channel.

77. The method according to claim 76, wherein the system comprises a sensor to sense parameters of the perfusion fluid and / or organ, the sensor being in data communication with the control unit or the remote-control station, wherein the method comprises: receiving sensing data, by the control unit or remote-control station; determining, by the control unit or remote-control station, whether the received sensing data comprise a sensing value above or below a predetermined threshold sensing value.

78. The method according to claim 77, wherein the system comprises at least one of a temperature sensor, a pressure sensor, a flowmeter, a pH sensor, an oxygen sensor, a glucose sensor, a lactate sensor, or a combination thereof.

79. The method according to any of claims 77 - 78, wherein the sensing data comprises at least one of hematocrit in the perfusion fluid, hemoglobin in the perfusion fluid,oxygen saturation in the perfusion fluid, pH in the perfusion fluid, oxygen partial pressure, partial pressure of CO2, bicarbonate level, potassium level.

80. The method according to any of claims 77 - 79, comprising: triggering, by the control unit or the remote-control station, an alarm signal when the sensing value is above or below a predetermined threshold sensing value.

81. The method according to claim 80, comprising: producing, by the control unit or the remote-control station, the alarm signal including an alarm parameter.

82. The method according to claim 81 , comprising: determining, by the control unit or the remote-control station, an organ state index based at least on the alarm parameter.

83. The method according to claim 82, wherein the organ state index comprises an organ viability index.

84. The method according to any of claims 81 - 83, wherein the alarm parameters comprise timing, duration, and kind of the alarm signal.

85. The method according to any of claims 80 - 84, wherein the organ state index is determined considering donor data.

86. The method according to any of claims 77 - 85, wherein the system comprises a driving pump to drive perfusion fluid from a circuit reservoir, and the sensor comprises a pressure sensor to sense pressure of the perfusion fluid in the inlet line, and a flowmeter to sense flow rate in the inlet line, wherein the method comprises: controlling, by the control unit or remote-control station, the operation of the driving pump based on the pressure sensing data and flow sensing data of the perfusion fluid in the inlet line.

87. The method according to any of claims 75 - 86, wherein the system comprises a gall connection configured to be fluidly connected to a gallbladder of a liver to be transported, and a bile flow sensor associated with the gall connection to sense the bile of the transported liver, wherein the method comprises: receiving bile sensing data, anddetermining whether the received bile sensing data comprise bile sensing value above or below a predetermined threshold bile sensing value.

88. The method according to any of claims 75 - 87, wherein the system comprises a ureter connection that is configured to be in fluid connection with the kidney ureter and to the circuit reservoir, and a urine flow meter associated with the ureter connection and configured to sense a urine flow rate, wherein the method comprises: receiving urine sensing data, and determining whether the received urine sensing data comprise urine sensing value above or below a predetermined threshold urine sensing value.

89. The method according to any of claims 75 - 88, wherein the system comprises a positioning device in data communication with the control unit, and / or the remotecontrol station, wherein the method comprises: correlating, by the control unit or remote-control station, the received sensing data and positioning data from the positioning device.

90. The method according to any of claims 75 - 89, comprising: receiving, by the control unit or remote-control station, user input comprising initial values and target values of parameters related to the perfusion process over a predetermined period; computing, by the control unit or remote-control station, a duration of the perfusion process based on the initial values and target values.91 . The method according to any of claims 75 - 90, comprising: receiving, by the control unit or remote-control station, coordinates of the donor site and the coordinates of the transplant site; calculating, by the control unit or remote-control station, an expected duration of transportation.

92. The method according to any of claims 77 - 91 , wherein the sensor comprises a temperature sensor, the method comprising: setting, by the control unit or remote-control station, a temperature target value of the perfusion fluid to be fed to the organ; receiving temperature data, by the control unit or remote-control station, of the perfusion fluid; determining, by the control unit or remote-control station, a duration and heatpower to be applied by the heat exchanger to achieve the temperature target value; commanding, by the control unit or remote-control station, the heat exchanger to adjust the temperature of the perfusion fluid.

93. The method according to any of claims 77 - 92, wherein the sensor comprises a pressure sensor, the method comprising: setting, by the control unit or remote-control station, a pressure target value of the perfusion fluid to be fed to the organ; receiving pressure data, by the control unit or remote-control station, of the perfusion fluid; determining, by the control unit or remote-control station, speed value of the driving pump to achieve the pressure target value; commanding, by the control unit or remote-control station, the driving pump to adjust the pressure of the perfusion fluid.

94. The method according to any of claims 77 - 93, wherein the system comprises a drug pump to provide the metering port with fluid media, a drug sensor in data communication with the control unit or the remote control unit, the drug sensor being associated with the fluid circuit to sense a drug concentration value of the perfusion fluid, the method comprising: setting, by the control unit or remote-control station, a drug concentration target value to be fed to the perfusion fluid; receiving, by the control unit or remote-control station, the drug concentration target value; determining, by the control unit or remote-control station, speed value of the drug pump to achieve the drug concentration target value; commanding, by the control unit or remote-control station, the drug pump to adjust the drug concentration value.

95. The method according to any of claims 77 - 94, wherein the system comprises a pressure actuator configured to apply pressure to a first target region of the base, wherein the pressure actuator is configured to move relative to the base to apply pressure to a second target region different from the first target region; wherein the method comprises: setting duration and speed, by the control unit or remote-control station, of a rotating movement of the pressure actuator.

96. A perfusion fluid to be fed to an organ held by an organ transport system according to any of claims 1 - 74.

97. A receptacle to be held by an organ transport system according to any of claims 1 - 74.

98. An organ transport system comprising a system frame, a receptacle according to any of claims 1 - 74, and a plurality of functional sections.

99. The system according to claim 98, wherein the functional sections comprise a fluid circuit section, a sensor section, a ureter section, a dialyzer section, a metering drug section, a draining pump section, and a control section.

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