Pipette provided with tip-feeding cartridge

Abstract

A pipette provided with a tip-feeding cartridge (2), comprising: a pipette body (1), a tip-feeding cartridge (2), and a cartridge driving mechanism. The cartridge driving mechanism is provided beside the pipette body (1). The tip-feeding cartridge (2) is fixedly mounted at a lower end of the cartridge driving mechanism. The tip-feeding cartridge (2) comprises a cartridge housing (12), a tip pushing device, and a plurality of pipette tips (13) arranged in sequence. The cartridge housing (12) is provided with a tip outlet through-hole vertically extending therethrough, and a pipette piston cylinder (6) at a lower part of the pipette body (1) passes through the tip outlet through-hole. The tip pushing device pushes the pipette tips (13) toward the tip outlet through-hole. The cartridge driving mechanism drives the tip-feeding cartridge (2) to move downward and upward, so that a pipette tip (13) is sleeved on a pipette nozzle (7). A release pin (17) is provided on a lower inner side of the cartridge housing (12), so that when the tip-feeding cartridge (2) moves downwards, the tip (13) on the pipette nozzle (7) is caught by the release pin (17) and thus separated from the pipette nozzle (7).

Description

Pipette with tip supply

[0001] Cross-reference to Related Applications

[0002] This application is based on and claims priority to Chinese Patent Application No. 202411105898.9, filed on August 13, 2024, the entire contents of which are incorporated herein by reference. TECHNICAL FIELD

[0003] The present disclosure relates to the field of pipettes, in particular to a pipette with tip supply. BACKGROUND

[0004] A pipette, also known as a pipet, is a common tool for quantitatively pipetting liquid samples, which is widely used in biological, medical, chemical and material fields. The structural components of a pipette mainly include a push button, a volume adjustment button, a volume display window, a tip removal button, a removal rod (cylinder), a suction rod, a suction nozzle and a disposable tip, etc. When using a pipette, first rotate the volume adjustment button, stop rotating when the required volume number appears in the volume display window, and then insert a disposable tip into the suction nozzle at the lower end of the pipette to start pipetting the liquid sample. After the liquid is taken, press the tip removal button to remove the used disposable tip.

[0005] Usually, the disposable tip is placed vertically in a special containing box with the sharp end facing down and the thick end facing up. The containing box has a neat multi-hole placement tray inside to place multiple tips. During the process of inserting the disposable tip into the suction nozzle at the lower end of the pipette, the lid of the containing box needs to be opened, which exposes other unused tips to the air, making them easily stick to dust and other impurities, thereby affecting use. In addition, the pipette nozzle may not contact well during the process of inserting the tip due to positional deviation or uneven force, so multiple pressing and twisting are needed to ensure air tightness, which is poor in operability, especially for multi-channel pipettes that need to be used frequently, which greatly increases the labor intensity of the operator. SUMMARY

[0006] The purpose of the present disclosure is to provide a pipette with tip supply, which can automatically load and unload tips, reduce the labor intensity of the operator, improve the pipetting efficiency, and avoid contamination of the tips by the external environment.

[0007] In order to achieve the above object, the technical scheme adopted by the present disclosure is: a pipette with a tip supply device, comprising a pipette main body, a tip supply device and a tip supply device driving mechanism, the tip supply device driving mechanism is arranged beside the pipette main body, the tip supply device is fixedly installed at the lower end of the tip supply device driving mechanism, the tip supply device comprises a tip supply device shell, a tip pushing device arranged in the tip supply device shell and a plurality of tips arranged in sequence, a tip outlet through hole is formed in the tip supply device shell, and a pipette piston cylinder at the lower part of the pipette main body passes through the tip outlet through hole, the tip pushing device pushes the tips towards the tip outlet through hole, the tip supply device driving mechanism drives the tip supply device to move downward to put the tips on the pipette nozzle at the lower end of the pipette piston cylinder, and a dismounting pin is arranged at the lower part of the inner side of the tip supply device shell to clamp the tips on the pipette nozzle when the tip supply device moves downward, so that the tips are separated from the pipette nozzle.

[0008] In some embodiments, the tip supply device driving mechanism is a manual driving mechanism, which comprises a mounting frame, a pressing part, a top rod and a return spring, the mounting frame is fixedly connected beside the pipette main body, the top rod is installed in the mounting frame and can move up and down, a plurality of limiting guide sleeves are arranged vertically on the inner side of the mounting frame to guide the movement of the top rod, the upper end of the top rod is fixedly connected with the pressing part, the lower end of the top rod is fixedly connected with the tip supply device, and the return spring is installed between the pressing part and the uppermost limiting guide sleeve to drive the top rod to reset after downward movement.

[0009] In some embodiments, the tip supply device driving mechanism is an electrically controlled driving mechanism, which comprises a mounting frame, a power supply battery, a motor, a lead screw, an electric push rod and a motor control button, the mounting frame is fixedly connected beside the pipette main body, the power supply battery and the motor are fixedly installed in the mounting frame, and the output end of the motor is connected downward with the lead screw to drive the lead screw to rotate, the lower part of the lead screw is matched with the electric push rod to drive the electric push rod to move up and down through the forward and reverse rotation of the lead screw, the lower end of the electric push rod is fixedly connected with the upper end of the top rod, and the lower end of the top rod is fixedly connected with the tip supply device; the power supply battery supplies power to the motor, and the motor control button is connected with the control end of the motor to control the start and stop and the forward and reverse rotation of the motor.

[0010] In some embodiments, the tip supply device comprises a tip cartridge, a tip magazine, a tip cylinder, a tip drum, a tip spiral drum, a tip disc, a tip belt, a tip plate, a tip chain, a tip nest, a tip box, a tip hopper and a tip clip.

[0011] In some embodiments, the pipette main body mainly comprises a shell, a control button, a counter, a volume adjustment button, a volume display window, a pipette piston rod and a pipette piston cylinder.

[0012] In some embodiments, the pipette body is a single-channel pipette body, the supply shell is provided with a single tip pushing device and a single row of tips inside the supply shell, and a single upper and lower through tip outlet through-hole is formed in the supply shell.

[0013] In some embodiments, the tip supply is a tip drum, which comprises a tip drum shell and a plurality of tips, a coil spring and a pushing slider arranged in the tip drum shell. A guide partition is arranged in the tip drum shell to arrange the plurality of tips in the tip drum shell in order. One end of the coil spring is fixedly connected to the tip drum shell, and the other end is fixedly connected to the pushing slider. The pushing slider pushes the plurality of tips arranged in order along the guide partition from the rear to the tip outlet through-hole. A wedge-shaped disengaging pin is arranged at the lower part of the inner side of the tip drum. The tip has a sharp end facing downward and a thick end facing upward, so that the tip can smoothly pass through the tip drum when the tip drum moves upward, and the tip can be separated from the pipette nozzle when the tip drum moves downward.

[0014] In some embodiments, the pipette body is a multi-channel pipette body, which comprises a piston mechanism housing, a driving rod, a piston push plate, a plurality of pipette piston rods and a plurality of pipette piston cylinders. The plurality of pipette piston cylinders are installed side by side in the piston mechanism housing and downwardly pass through the piston mechanism housing. The lower end of the driving rod is fixedly connected to the upper part of the piston push plate. The lower part of the piston push plate is fixedly connected to the plurality of pipette piston rods arranged side by side in the piston mechanism housing. The plurality of pipette piston rods are respectively matched with the corresponding pipette piston cylinders. The multi-channel pipette body drives the piston push plate and the plurality of pipette piston rods below the piston push plate to move up and down through the driving rod. The supply shell is provided with a plurality of tip pushing devices and a plurality of rows of tips inside the supply shell, and a plurality of upper and lower through tip outlet through-holes are formed in the supply shell. The plurality of tip pushing devices respectively push the corresponding rows of tips to the corresponding tip outlet through-holes. A plurality of disengaging pins are respectively arranged at the lower part of the inner side of the supply shell corresponding to the plurality of tip outlet through-holes.

[0015] In some embodiments, the tip supply device is a multi-lane tip magazine, which comprises a multi-lane tip magazine shell, a plurality of tips arranged in the multi-lane tip magazine shell, a plurality of tip pushing springs and a plurality of tip pushing plates. The multi-lane tip magazine shell is provided with a plurality of tip magazine partitions arranged side by side in the multi-lane tip magazine shell to divide the multi-lane tip magazine shell into a plurality of tip conveying channels. Each tip conveying channel is regularly arranged with the plurality of tips and is provided with the tip pushing spring and the tip pushing plate. Each tip conveying channel is provided with a tip outlet through hole at the front end. One end of the tip pushing spring is fixedly connected to the multi-lane tip magazine shell, and the other end is fixedly connected to the tip pushing plate. The tip pushing plate pushes the regularly arranged plurality of tips along the tip conveying channel from the rear to the tip outlet through hole. The multi-lane tip magazine is provided with a plurality of wedge-shaped disengagement pins at the lower part of the inner side of the multi-lane tip magazine corresponding to the plurality of tip conveying channels. The tip has a tip mouth facing downward and a thick mouth facing upward, so that the tip can smoothly pass through the multi-lane tip magazine when the multi-lane tip magazine moves upward, and the tip can be separated from the pipette nozzle when the multi-lane tip magazine moves downward.

[0016] The present disclosure has the following beneficial effects: the present disclosure provides a pipette with a tip supply device, which can store a plurality of tips in the self-provided tip supply device, and realize automatic installation and disengagement of the tips through cooperation of the tip supply device and the pipette main body. The pipette not only reduces the labor intensity of the operator and improves the pipetting efficiency, but also avoids pollution of the tips by the external environment, and has strong practicability and broad application prospect. BRIEF DESCRIPTION OF DRAWINGS

[0017] FIG. 1 is a front view of a single-lane pipette with a tip drum according to an embodiment of the present disclosure;

[0018] FIG. 2 is a rear view of the single-lane pipette with the tip drum according to the embodiment of the present disclosure;

[0019] FIG. 3 is a side view of the single-lane pipette with the tip drum according to the embodiment of the present disclosure;

[0020] FIG. 4 is an A-A sectional view of FIG. 3;

[0021] FIG. 5 is a top view of the single-lane pipette with the tip drum according to the embodiment of the present disclosure;

[0022] FIG. 6 is a partial sectional view of the single-lane pipette with the tip drum in an initial state according to the embodiment of the present disclosure;

[0023] FIG. 7 is a partial sectional view of the single-lane pipette with the tip drum when the hand control driving mechanism is partially compressed according to the embodiment of the present disclosure;

[0024] FIG. 8 is a partial sectional view of the single-lane pipette with the tip drum when the hand control driving mechanism is fully compressed according to the embodiment of the present disclosure;

[0025] Figure 9 is a partial cross-sectional view of the single-channel pipette with the tip drum in the partially-retracted position of the hand-actuated drive mechanism of the first embodiment of the present disclosure;

[0026] Figure 10 is a partial cross-sectional view of the single-channel pipette with the tip drum in the fully-retracted position of the hand-actuated drive mechanism of the first embodiment of the present disclosure;

[0027] Figure 11 is a partial cross-sectional view of the single-channel pipette with the tip drum in the partially-compressed position of the hand-actuated drive mechanism of the first embodiment of the present disclosure;

[0028] Figure 12 is a front view of a conventional multi-channel pipette;

[0029] Figure 13 is a front view of the multi-channel pipette with the multi-channel tip magazine of the second embodiment of the present disclosure;

[0030] Figure 14 is a rear view of the multi-channel pipette with the multi-channel tip magazine of the second embodiment of the present disclosure;

[0031] Figure 15 is a partial cross-sectional view of the multi-channel pipette with the multi-channel tip magazine of the second embodiment of the present disclosure;

[0032] Figure 16 is a side view of the multi-channel pipette with the multi-channel tip magazine of the second embodiment of the present disclosure;

[0033] Figure 17 is a B-B cross-sectional view of Figure 16;

[0034] Figure 18 is a partial cross-sectional view of the multi-channel pipette with the multi-channel tip magazine in the initial position of the second embodiment of the present disclosure;

[0035] Figure 19 is a partial cross-sectional view of the multi-channel pipette with the multi-channel tip magazine in the partially-compressed position of the hand-actuated drive mechanism of the second embodiment of the present disclosure;

[0036] Figure 20 is a partial cross-sectional view of the multi-channel pipette with the multi-channel tip magazine in the fully-compressed position of the hand-actuated drive mechanism of the second embodiment of the present disclosure;

[0037] Figure 21 is a partial cross-sectional view of the multi-channel pipette with the multi-channel tip magazine in the partially-retracted position of the hand-actuated drive mechanism of the second embodiment of the present disclosure;

[0038] Figure 22 is a partial cross-sectional view of the multi-channel pipette with the multi-channel tip magazine in the fully-retracted position of the hand-actuated drive mechanism of the second embodiment of the present disclosure;

[0039] Figure 23 is a partial cross-sectional view of the multi-channel pipette with the multi-channel tip magazine in the partially-compressed position of the hand-actuated drive mechanism of the second embodiment of the present disclosure;

[0040] Figure 24 is a partial cross-sectional view of the single-channel pipette with the electrically-actuated tip drum in the initial position of the third embodiment of the present disclosure;

[0041] Figure 25 is a partial cross-sectional view of a single-channel pipette with the electrically controlled drive mechanism fully extended in accordance with an embodiment of the present disclosure.

[0042] Figure 26 is a partial cross-sectional view of a single-channel pipette with the electrically controlled drive mechanism fully retracted in accordance with an embodiment of the present disclosure.

[0043] Figure 27 is a partial cross-sectional view of a single-channel pipette with the electrically controlled drive mechanism partially extended again in accordance with an embodiment of the present disclosure.

[0044] In the figures: 1 - single-channel pipette body, 2 - tip drum, 3 - control button, 4 - volume adjustment button, 5 - volume display window, 6 - pipette piston cylinder, 7 - pipette nozzle, 8 - pressing portion, 9 - ejector rod, 10 - return spring, 11 - spring washer, 12 - tip drum housing, 13 - tip, 14 - guide partition, 15 - coil spring, 16 - push block, 17 - release pin, 18 - limit guide sleeve, 19 - fixing bolt, 20 - multi-channel pipette body, 21 - lower portion of multi-channel pipette body, 22 - piston mechanism housing, 23 - multi-channel tip magazine, 24 - multi-channel tip magazine housing, 25 - multi-channel pipette nozzle, 26 - drive rod, 27 - piston push plate, 28 - clamping groove, 29 - pipette piston rod, 30 - fixing groove, 31 - pipette piston cylinder, 32 - tip magazine partition, 33 - magazine spring washer, 34 - tip push plate, 35 - tip push spring, 36 - single-channel pipette body, 37 - motor control button, 38 - power supply battery, 39 - motor, 40 - electric push rod, 41 - screw rod. DETAILED DESCRIPTION

[0045] The present disclosure is further described in the detailed description that follows, in connection with the accompanying drawings and embodiments.

[0046] It should be noted that the following detailed description is exemplary in nature and is intended to provide further description of the application. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

[0047] It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting. As used herein, the singular form "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.

[0048] Meanwhile, in the description of the present disclosure, it needs to be understood that the terms "upper", "lower", "front", "back", "inner", "outer" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present disclosure and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present disclosure. In the present disclosure, unless otherwise explicitly specified and limited, the first feature is "on" or "under" the second feature, which can be that the first and second features are in direct contact, or the first and second features are indirectly in contact through an intermediate medium. Moreover, the first feature "above", "over" and "on" the second feature can be that the first feature is directly above or obliquely above the second feature, or only indicates that the horizontal height of the first feature is higher than that of the second feature. The first feature "below", "under" and "under" the second feature can be that the first feature is directly below or obliquely below the second feature, or only indicates that the horizontal height of the first feature is less than that of the second feature.

[0049] In the present disclosure, unless otherwise explicitly specified and limited, the terms "mounting", "connecting", "connecting", "fixing" and the like should be understood broadly, for example, it can be fixedly connected, or it can be detachably connected, or it can be integrated; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium; it can be the internal communication of two elements or the interaction relationship between two elements. For those skilled in the art, the specific meanings of the above terms in the present disclosure can be understood according to the specific circumstances.

[0050] In addition, it should also be understood that when the terms "contain" and / or "include" are used in the present specification, it indicates the presence of a feature, step, operation, device, component and / or their combination. The specific features, structures, materials or characteristics described in the present disclosure can be combined in any one or more embodiments in a suitable manner. Those skilled in the art can combine and combine the different embodiments or examples described in the present specification and the features of the different embodiments or examples without contradiction.

[0051] As shown in FIG. 1-11, the present disclosure provides a pipette with tip supply device, which comprises a pipette body 1, a tip supply device 2 and a tip supply device driving mechanism arranged beside the pipette body 1, the tip supply device 2 is fixedly installed at the lower end of the tip supply device driving mechanism, the tip supply device 2 comprises a tip supply device shell 12 and a tip pushing device and a plurality of tips 13 arranged in sequence in the tip supply device shell 12, the tip supply device shell 12 is provided with a tip outlet through hole penetrating from top to bottom and the pipette piston cylinder 6 at the lower part of the pipette body 1 penetrates through the tip outlet through hole, the tip pushing device pushes the tips 13 to the tip outlet through hole, the tip supply device driving mechanism drives the tip supply device 2 to move downward to make the tips 13 fit on the pipette nozzle 7 at the lower end of the pipette piston cylinder 6, and the tip supply device shell 12 is provided with a disengaging pin 17 at the inner lower part to clamp the tips 13 on the pipette nozzle 7 to separate the tips 13 from the pipette nozzle 7 when the tip supply device 2 moves downward.

[0052] The tip supply device driving mechanism can be a hand control driving mechanism or an electric control driving mechanism.

[0053] As shown in FIG. 6-11, in the first embodiment, the tip supply device driving mechanism is a hand control driving mechanism, which comprises a mounting bracket, a pressing part 8, a top rod 9 and a return spring 10, the mounting bracket is fixedly connected beside the pipette body 1, the top rod 9 is installed in the mounting bracket and can move up and down, a plurality of limiting guide sleeves 18 are arranged vertically on the inner side of the mounting bracket to guide the movement of the top rod 9, the top rod 9 is fixedly connected with the pressing part 8 at the upper end, the top rod 9 is fixedly connected with the tip supply device at the lower end, and the return spring 10 is installed between the pressing part 8 and the uppermost limiting guide sleeve 18 (a spring washer 11 is arranged between the return spring 10 and the pressing part 8) to drive the top rod to return after moving downward.

[0054] As shown in FIG. 24-27, in the third embodiment, the tip supply device driving mechanism is an electric control driving mechanism, which comprises a mounting bracket, a power supply battery 38, a motor 39, a lead screw 41, an electric push rod 40 and a motor control button 37, the mounting bracket is fixedly connected beside the pipette body 36, the power supply battery 38 and the motor 39 are fixedly installed in the mounting bracket, and the output end of the motor 39 is connected downward with the lead screw 41 to drive the lead screw 41 to rotate, the lower part of the lead screw 41 cooperates with the electric push rod 40 to drive the electric push rod 40 to move up and down through the forward and reverse rotation of the lead screw 41, the lower end of the electric push rod 40 is fixedly connected with the upper end of the top rod 9, and the lower end of the top rod 9 is fixedly connected with the tip supply device; the power supply battery 38 supplies power to the motor 39, and the motor control button 37 is connected with the control end of the motor 39 to control the start and stop and the forward and reverse rotation of the motor.

[0055] The tip supply device can be in various structural forms, including but not limited to a tip magazine, a tip magazine, a tip drum, a tip drum, a tip spiral drum, a tip tray, a tip belt, a tip plate, a tip chain, a tip nest, a tip box, a tip hopper, a tip clip, etc.

[0056] The pipette body can be a single-channel pipette body or a multi-channel pipette body.

[0057] As shown in FIGS. 1-11, in embodiment one, the pipette body is a single-channel pipette body 1, and the tip supply device is a tip drum 2. The single-channel pipette body 1 mainly includes a shell, a control button 3, a counter, a volume adjustment button 4, a volume display window 5, a pipette piston rod and a pipette piston cylinder 6. The tip drum 2 includes a tip drum shell 12 and a plurality of tips 13, a coil spring 15 and a push slider 16 arranged therein. A single tip pushing device and a single row of tips are arranged in the tip drum shell 12, and a single upper and lower through tip outlet through hole is formed in the supply device shell. A guide partition plate 14 is arranged in the tip drum shell 12 to arrange the plurality of tips 13 in the tip drum shell 12 in order. One end of the coil spring 15 is fixedly connected with the tip drum shell 12, and the other end is fixedly connected with the push slider 16. The push slider 16 pushes the plurality of tips 13 arranged in order along the guide partition plate 14 from the rear to the tip outlet through hole. A wedge-shaped disengaging pin 17 is arranged on the inner side of the lower part of the tip drum. The tip has a downward pointed end and an upward thick end, so that the tip can smoothly pass through the tip drum when the tip drum moves upward, and the upper end of the tip is clamped on the pipette nozzle to separate the tip from the pipette nozzle when the tip drum moves downward.

[0058] As shown in FIGS. 13-23, in embodiment two, the pipette body is a multi-channel pipette body 20, and the tip supply device is a multi-channel tip magazine 23. In addition to including a housing, a control button 3, a counter, a volume adjustment button 4, and a volume display window 5, the multi-channel pipette body lower portion 21 further includes a piston mechanism housing 22, a drive rod 26, a piston push plate 27, a plurality of pipette piston rods 29, and a plurality of pipette piston cylinders 31. The plurality of pipette piston cylinders 31 are installed side by side in the piston mechanism housing 22 and pass downward through fixed slots 30 on the lower end face of the piston mechanism housing. The lower end of the drive rod 26 is fixedly connected to the upper portion of the piston push plate 27, and the lower portion of the piston push plate 27 is fixedly connected to the plurality of pipette piston rods 29 that are arranged side by side in the piston mechanism housing. The plurality of pipette piston rods 29 are respectively matched with corresponding pipette piston cylinders 31. The multi-channel pipette body drives the piston push plate and the plurality of pipette piston rods below it to move upward and downward by means of the drive rod. The tip supply device housing has a plurality of tip push devices and a plurality of rows of tips arranged correspondingly therein. A plurality of tip outlet through holes that pass upward and downward are formed in the tip supply device housing. The plurality of tip push devices respectively push the tips of the corresponding rows toward the corresponding tip outlet through holes. A plurality of disengagement pins are arranged correspondingly on the inner lower portion of the tip supply device housing with respect to the plurality of tip outlet through holes.

[0059] The following further describes the implementation of the pipette with a tip supply device according to the present disclosure based on embodiments one, two, and three.

[0060] Embodiment one

[0061] The embodiment provides a single-channel pipette with tip drum, which comprises a single-channel pipette body 1, a tip drum 2 and a drive mechanism for the drum. As shown in FIG. 1, FIG. 2, FIG. 3, FIG. 5 and FIG. 6, the pipette body 1 comprises a shell, a control button 3, a counter, a volume adjustment button 4, a volume display window 5, a pipette piston rod, a pipette piston cylinder 6, a pipette nozzle 7 and the like, and the drive mechanism for the drum comprises a pressing part 8, a top rod 9, a return spring 10, a spring washer 11, a limiting guide sleeve 18 and a fixing bolt 19. The top rod 9 is connected with the tip drum shell 12 (the tip drum 2) through the fixing bolt 19, so that the tip drum shell 12 (the tip drum 2) can be controlled to move downward by the top rod 9 by pressing the pressing part 8, and the limiting guide sleeve 18 ensures that the top rod 9 and the tip drum 2 do not deviate during the movement. On the contrary, when the pressing part 8 is released, the tip drum shell 12 (the tip drum 2) is driven to move upward by the restoring force of the return spring 10.

[0062] As shown in FIG. 4 and FIG. 6, the tip drum 2 comprises a tip drum shell 12, a tip 13, a guide partition plate 14, a coil spring 15, a pushing slider 16 and a disengaging pin 17. The tip drum 2 is filled with a plurality of tips 13 which are vertically arranged with the pointed end downward and the thick end upward. Under the action of the elastic force of the coil spring 15, the pushing slider 16 pushes the tips 13 forward along the channel formed by the tip drum shell 12 and the partition plate 14.

[0063] As shown in Fig. 3, Fig. 6 and Fig. 7, the pipette presses the pressing part 8, the ejector rod 9 drives the tip ejector housing 12 (tip ejector 2) to move down and separate from the pipette piston cylinder 6, while the return spring 10 is compressed. When the tip ejector housing 12 (tip ejector 2) is about to leave the pipette nozzle 7 (as shown in Fig. 8), the slider 16 pushes the tip 13 to the space below the pipette nozzle 7, i.e. the space left by the pipette piston cylinder 6, by the elastic force of the coil spring 15. Releasing the pressing part 8, the ejector rod 9 is driven by the restoring force of the return spring 10 to move the tip ejector housing 12 (tip ejector 2) up (as shown in Fig. 9), in the process, the nozzle 7 is inserted into the upper end of the tip 13 and tightly combined under the action of the friction force around, when the tip ejector 2 (tip ejector housing 12) moves to the initial position (as shown in Fig. 10), the pipette has been installed with the tip and can start the pipetting operation. Observe the volume display window 5, rotate the volume adjustment button 4 to the desired number, insert the pipette tip 13 into the liquid surface below the liquid to be taken, press the control button 3 to remove the air, then release, the liquid is sucked into the pipette tip 13. After the liquid is sucked, remove the pipette tip 13 and insert it into another container, press the control button 3 to discharge the liquid. After the pipetting is completed, press the pressing part 8 again, the tip ejector housing 12 (tip ejector 2) and the dismounting pin 17 on the inner wall move down together, when the nozzle 7 with the tip 13 hits the dismounting pin 17, the separation occurs (as shown in Fig. 11), the tip 13 is dismounted. The pipette of the present disclosure realizes the automatic installation and dismounting of the pipette tip 13 by operating the pressing part 8 and the tip ejector 2.

[0064] Example Two

[0065] The present embodiment provides a multi-channel pipette with a tip magazine. Unlike the ordinary multi-channel pipette (as shown in Fig. 12), it comprises a multi-channel pipette body 20, a multi-channel tip magazine 23 and a magazine driving mechanism. As shown in Fig. 13, Fig. 14, Fig. 15, Fig. 16 and Fig. 18, the multi-channel pipette body 20 comprises a shell, a control button 3, a counter, a volume adjustment button 4, a volume display window 5, etc. The lower part 21 of the multi-channel pipette body comprises a shell 22, a multi-channel pipette nozzle 25, a driving rod 26, a piston push plate 27, a clamping groove 28, a piston rod 29, a fixing groove 30, a multi-channel pipette piston cylinder 31, etc. The magazine driving mechanism comprises a pressing part 8, an ejector rod 9, a return spring 10, a spring washer 11, a limiting guide sleeve 18 and a fixing bolt 19. As shown in Fig. 17 and Fig. 18, the multi-channel tip magazine 23 comprises a multi-channel tip magazine housing 24, a tip 13, a dismounting pin 17, a tip magazine partition plate 32, a magazine spring washer 33, a tip pushing plate 34 and a tip pushing spring 35. Each channel in the tip magazine 23 is arranged with multiple tips 13, which are vertically arranged with the sharp end downward and the thick end upward. Under the action of the elastic force of the tip pushing spring 35, the tip pushing plate 34 pushes these tips 13 forward along the channel surrounded by the tip magazine partition plate 32.

[0066] As shown in Fig. 15, Fig. 16, Fig. 18 and Fig. 19, the multi-channel pipette presses the pressing part 8, the ejector rod 9 drives the multi-channel tip magazine shell 24 (multi-channel tip magazine 23) to move downward and separate from the multi-channel pipette piston cylinder 31, while the return spring 10 is compressed. When the multi-channel tip magazine shell 24 (multi-channel tip magazine 23) is about to leave the multi-channel pipette nozzle 25 (as shown in Fig. 20), the tip pushing plate 34 pushes the whole row of tips 13 to the space below the multi-channel pipette nozzle 25, i.e. the space left by the multi-channel pipette piston cylinder 31, by the elastic force of the tip pushing spring 35. Releasing the pressing part 8, the ejector rod 9 is driven by the restoring force of the return spring 10 to move the multi-channel tip magazine shell 24 (multi-channel tip magazine 23) upward (as shown in Fig. 21). In this process, the multi-channel pipette nozzle 25 is inserted into the upper end of the tip 13 and tightly combined by the friction force around. When the multi-channel tip magazine shell 24 (multi-channel tip magazine 23) moves to the initial position (as shown in Fig. 22), the pipette has been installed with the tips and can start the pipetting operation.

[0067] Observing the volume display window 5, rotating the volume adjusting button 4 to the desired number, inserting the pipette tip 13 into the liquid surface below the liquid to be taken. Pressing the control button 3, the drive rod 26 connects the piston pushing plate 27 to drive the whole row of piston rods 29 to move downward (as shown in Fig. 15), and then releasing after removing the air, the liquid is sucked into the pipette tip 13. After the liquid is sucked, remove the pipette tip 13 and insert it into another container, press the control button 3 to discharge the liquid. After the pipetting is completed, press the pressing part 8 again, the multi-channel tip magazine shell 24 (multi-channel tip magazine 23) and the disengagement pin 17 on the inner wall move downward together. When the multi-channel pipette nozzle 25 with the whole row of tips 13 hits the disengagement pin 17, it is separated (as shown in Fig. 23), the tip 13 is disengaged, and a cycle is completed.

[0068] Example Three

[0069] This example provides a single-channel pipette with electrically controlled tip drum driving mechanism, which is different from the pipette in Example One in that an electrically controlled driving mechanism is used instead of a manually controlled driving mechanism. As shown in Fig. 24, Fig. 25, Fig. 26 and Fig. 27, the electrically controlled driving mechanism includes a motor control button 37, a power supply battery 38, a motor 39, an electric push rod 40, a lead screw 41, an ejector rod 9, etc.

[0070] The pipette presses the motor control button 37, the motor 39 is powered to start driving the screw rod 41 to rotate, and the connecting rod 9 and the tip drum shell 12 (the tip drum 2) move downward and separate from the pipette piston cylinder 6. When the tip drum shell 12 (the tip drum 2) is about to leave the pipette nozzle 7 (as shown in FIG. 25), the slider 16 (as shown in FIG. 4) pushes the tip 13 to the space below the nozzle 7, i.e. the space left by the pipette piston cylinder 6, by the elastic force of the coil spring 15. Press the motor control button 37, the motor 39 is powered to start driving the screw rod 41 to reverse, and the connecting rod 9 and the tip drum shell 12 (the tip drum 2) move upward. In this process, the nozzle 7 is inserted into the upper end of the tip 13 and tightly combined under the action of the friction force around, when the tip drum 2 (the tip drum shell 12) moves to the initial position (as shown in FIG. 26), the pipette has installed the tip and can start the pipetting operation. After the pipetting is finished, the motor control button 37 is pressed again, the tip drum shell 12 (the tip drum 2) and the dismounting pin 17 on the inner wall move downward together, and the nozzle 7 with the tip 13 is separated when it hits the dismounting pin 17 (as shown in FIG. 27), the tip 13 is dismounted, and a cycle is completed. The electric control driving mechanism of the single-channel pipette for driving the tip drum in the embodiment can also be applied to the multi-channel pipette with the tip magazine.

[0071] The above is only part of the embodiments of the present disclosure, and is not a limitation on other forms of the present disclosure. Any skilled person in the art can modify or change the above disclosed technical content to equivalent embodiments. However, any simple modification, equivalent change and modification of the above embodiments without departing from the technical solution of the present disclosure, according to the technical essence of the present disclosure, still belongs to the protection scope of the present disclosure.

Claims

1. A pipette with tip supply device, comprising a pipette body, a tip supply device and a tip supply device driving mechanism; The tip supply device driving mechanism is arranged beside the pipette body, and the tip supply device is fixedly installed at the lower end of the tip supply device driving mechanism; The tip supply device comprises a tip supply device shell, a tip pushing device arranged in the tip supply device shell, and a plurality of tips arranged in sequence, the tip supply device shell is provided with a tip outlet through hole penetrating from top to bottom, and the pipette piston cylinder at the lower part of the pipette body penetrates through the tip outlet through hole, and the tip pushing device pushes the tips to the tip outlet through hole; The tip supply device driving mechanism drives the tip supply device to move upward and downward, so that the tip is sleeved on the pipette nozzle at the lower end of the pipette piston cylinder, and the inside of the lower part of the tip supply device shell is provided with a dismounting pin, so that the tip on the pipette nozzle is clamped when the tip supply device moves downward, and the tip is separated from the pipette nozzle.

2. The pipette of claim 1, wherein, The tip supply device driving mechanism is a manual driving mechanism, which comprises a mounting frame, a pressing part, a top rod and a reset spring, the mounting frame is fixedly connected beside the pipette body, the top rod is installed in the mounting frame and can move upward and downward, a plurality of limiting guide sleeves are vertically arranged on the inside of the mounting frame to guide the movement of the top rod, the upper end of the top rod is fixedly connected with the pressing part, the lower end of the top rod is fixedly connected with the tip supply device, and the reset spring is installed between the pressing part and the uppermost limiting guide sleeve to drive the top rod to reset after downward movement.

3. The pipette of claim 1, wherein, The tip supply device driving mechanism is an electrically controlled driving mechanism, which comprises a mounting frame, a power supply battery, a motor, a screw rod, an electric push rod and a motor control button, the mounting frame is fixedly connected beside the pipette body, the power supply battery and the motor are fixedly installed in the mounting frame, the output end of the motor is connected with the screw rod downward to drive the screw rod to rotate, the lower part of the screw rod is matched with the electric push rod to drive the electric push rod to move upward and downward through the forward and reverse rotation of the screw rod, the lower end of the electric push rod is fixedly connected with the upper end of the top rod, and the lower end of the top rod is fixedly connected with the tip supply device; the power supply battery supplies power to the motor, and the motor control button is connected with the control end of the motor to control the start and stop and forward and reverse rotation of the motor.

4. The pipette according to any one of claims 1 to 3, wherein, The tip supply device comprises a tip cartridge, a tip clip, a tip drum, a tip spiral drum, a tip belt, a tip plate, a tip chain, a tip nest, a tip box, a tip drum and a tip clip.

5. The pipette according to any one of claims 1 to 4, wherein, The pipette body mainly comprises a shell, a control button, a counter, a volume adjusting button, a volume display window, a pipette piston rod and a pipette piston cylinder.

6. The pipette according to any one of claims 1 to 5, wherein, The pipette body is a single channel pipette body, a single tip pushing device and a single row of tips are correspondingly arranged in the tip supply device shell, and a single tip outlet through hole penetrating from top to bottom is correspondingly formed on the tip supply device shell.

7. The pipette according to any one of claims 1 to 6, wherein, The tip supply device is a tip drum, which comprises a tip drum shell, the plurality of tips, a spiral spring and a push slider arranged in the tip drum shell. A guide partition is arranged in the tip drum shell to arrange the plurality of tips in order in the tip drum shell. One end of the spiral spring is fixedly connected with the tip drum shell, and the other end is fixedly connected with the push slider. The push slider pushes the plurality of tips arranged in order along the guide partition from the back to the tip outlet through hole. A wedge-shaped disengaging pin is arranged at the lower part of the inner side of the tip drum. The tip has a sharp end facing downward and a thick end facing upward, so that the tip can smoothly pass through the tip drum when the tip drum moves upward, and the upper end of the tip on the pipette nozzle is clamped to separate the pipette nozzle when the tip drum moves downward.

8. The pipette of any one of claims 1-5, wherein, The pipette body is a multi-channel pipette body, which comprises a piston mechanism shell, a driving rod, a piston push plate, a plurality of pipette piston rods and a plurality of pipette piston cylinders. The plurality of pipette piston cylinders are installed side by side in the piston mechanism shell and downwardly pass through the piston mechanism shell. The lower end of the driving rod is fixedly connected with the upper part of the piston push plate. The lower part of the piston push plate is fixedly connected with the plurality of pipette piston rods arranged side by side in the piston mechanism shell. The plurality of pipette piston rods are respectively matched with the corresponding pipette piston cylinders. The multi-channel pipette body drives the piston push plate and the plurality of pipette piston rods below the piston push plate to move up and down through the driving rod. A plurality of tip push devices and a plurality of rows of tips are respectively arranged in the supply device shell. A plurality of tip outlet through holes are respectively arranged in the supply device shell. The plurality of tip push devices respectively push the corresponding rows of tips to the corresponding tip outlet through holes. A plurality of disengaging pins are respectively arranged at the lower part of the inner side of the supply device shell corresponding to the plurality of tip outlet through holes.

9. The pipette of claim 8, wherein, The tip supply device is a multi-channel tip magazine, which comprises a multi-channel tip magazine shell, a plurality of tips, a plurality of tip pushing springs and a plurality of tip pushing plates arranged in the multi-channel tip magazine shell, a plurality of tip magazine partitions are arranged side by side in the multi-channel tip magazine shell to divide the multi-channel tip magazine shell into a plurality of tip conveying channels, the plurality of tips are regularly arranged in each tip conveying channel and provided with the tip pushing spring and the tip pushing plate, an upper and lower tip outlet through hole is formed at the front end of each tip conveying channel, one end of the tip pushing spring is fixedly connected with the multi-channel tip magazine shell, and the other end is fixedly connected with the tip pushing plate, the tip pushing plate pushes the regularly arranged plurality of tips along the tip conveying channel from the rear to the tip outlet through hole, a plurality of wedge-shaped disengagement pins are arranged on the inner side of the lower part of the multi-channel tip magazine corresponding to the plurality of tip conveying channels, the tip tip opening faces downward, and the thick opening faces upward, so that the tip can smoothly pass through when the multi-channel tip magazine moves upward, and the upper end of the tip on the pipette nozzle is clamped to separate the pipette nozzle when the multi-channel tip magazine moves downward.

Images