Oily composition and use thereof

Abstract

Provided in the present application are an oily composition and use thereof. The oily composition comprises, in a physiologically acceptable oily medium: (a) at least one emulsifier, the at least one emulsifier being selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or salt thereof, and / or acetylated hyaluronic acid or salt thereof; and (c) lactic acid. The mass ratio of the component (c) to the component (b) is > 30:1, the mass ratio of the component (c) to the component (a) is < 10:1, and the content of water in the composition is < 1%, which enables the component (b) to be stably and uniformly dissolved in an anhydrous or substantially anhydrous environment. This solves the problems of the difficulty in applying an ointment containing the component (b) on a production line and the instability of the ointment, thereby enabling easy manufacturing of personal care products such as diapers and sanitary napkins coated with the ointment containing the component (b), while maintaining the dryness performance of the personal care products.

Description

Oily compositions and their uses Technical Field

[0001] This application relates to an oily composition, and more particularly to an oily composition containing hyaluronic acid or its salt and / or acetylated hyaluronic acid or its salt, and its use. Background Technology

[0002] Applying an ointment to the surface of paper products such as diapers and sanitary napkins is a common method to reduce discomfort such as diaper rash for wearers. The principle is that when the ointment rubs against the wearer's skin, it migrates to the skin's surface, forming a protective film that prevents the stratum corneum from becoming overhydrated after being soaked in moisture, thus weakening the skin's barrier function.

[0003] To further enhance the skincare efficacy of ointments, skincare active ingredients such as sodium hyaluronate can be added. However, this approach faces significant technical challenges because substances like sodium hyaluronate are water-soluble. Adding them directly to the ointment only results in dispersed particles, which can clog the coating nozzles on the production line. Furthermore, the ointment may settle and separate during prolonged heated storage. Some researchers have attempted to use water-in-oil emulsions to dissolve sodium hyaluronate, but the water content in the emulsion can cause dampness in coated diapers and sanitary napkins, a desirable outcome that can also promote bacterial growth. Summary of the Invention

[0004] In response to the technical problems existing in the prior art, the inventors of this application, after in-depth research, discovered that physiologically acceptable oily media contain:

[0005] (a) at least one emulsifier, said at least one emulsifier being selected from polyether fatty acid ester emulsifiers;

[0006] (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and

[0007] (c) Lactic acid;

[0008] Wherein, the mass ratio of component (c) to component (b) is >30:1, and the mass ratio of component (c) to component (a) is <10:1.

[0009] Ingredient (b) can be stably and uniformly dissolved in an anhydrous or substantially anhydrous environment. This solves the problems of difficulty in coating ointments containing ingredient (b) on production lines and the instability of the ointments, thus making it easy to manufacture personal care products such as diapers and sanitary napkins coated with ointments containing ingredient (b).

[0010] The specific technical solution of this application is as follows:

[0011] 1. An oily composition comprising, in a physiologically acceptable oily medium:

[0012] (a) at least one emulsifier, said at least one emulsifier being selected from polyether fatty acid ester emulsifiers;

[0013] (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and

[0014] (c) Lactic acid;

[0015] Wherein, the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%.

[0016] 2. The composition according to claim 1, wherein the mass ratio of component (c) to component (b) is 33-300:1.

[0017] 3. The composition according to item 1 or 2, wherein the mass ratio of component (c) to component (a) is 0.5-7:1.

[0018] 4. The composition according to any one of claims 1-3, wherein the polyether fatty acid ester emulsifier comprises a polyethylene glycol fatty acid ester emulsifier.

[0019] 5. The composition according to claim 4, wherein the polyethylene glycol fatty acid ester emulsifier comprises PEG-30 dimerized hydroxystearate and / or PEG-5 glyceryl stearate.

[0020] 6. The use of the composition of any one of items 1-5 in the preparation of skin care products or personal care products.

[0021] 7. A personal care product comprising the composition described in any one of items 1-5.

[0022] 8. The application according to item 6 or the personal care product according to item 7, wherein the personal care product comprises one or more of tissues, diapers, nursing pads and sanitary napkins.

[0023] The effects of the invention

[0024] This application enables the stable and homogeneous dissolution of component (b) in an anhydrous or substantially anhydrous environment. This solves the problems of difficulty in coating ointments containing component (b) on production lines and the instability of the ointments, thereby making it easy to manufacture personal care products such as diapers and sanitary napkins coated with ointments containing component (b) and maintaining the dry properties of the personal care products.

[0025] Based on the above technology, this application can apply products containing the said component (b) that are anhydrous or substantially anhydrous to media that need to be coated, thereby giving fuller play to the effects of component (b). For example, in addition to being used in diapers and sanitary napkins, such products can also be used in paper products such as nursing pads and tissues. Attached Figure Description

[0026] Figures 1 to 4 are schematic diagrams of the appearance of mixtures numbered 1, 19, 20 and 27, respectively. Detailed Implementation

[0027] The present application will now be described in detail with reference to the described embodiments. Although specific embodiments of the present application are shown, it should be understood that the present application can be implemented in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this application will be thorough and complete, and will fully convey the scope of the present application to those skilled in the art.

[0028] It should be noted that certain terms are used in the specification and claims to refer to specific components. Those skilled in the art will understand that different terms may be used to refer to the same component. This specification and claims do not distinguish components based on differences in terminology, but rather on differences in function. The terms "comprising" or "including" used throughout the specification and claims are open-ended and should be interpreted as "comprising but not limited to." The following descriptions in the specification are preferred embodiments for carrying out this application; however, these descriptions are for the purpose of understanding the general principles of the specification and are not intended to limit the scope of this application. The scope of protection of this application shall be determined by the appended claims.

[0029] This application provides an oily composition comprising, in a physiologically acceptable oily medium:

[0030] (a) at least one emulsifier, said at least one emulsifier being selected from polyether fatty acid ester emulsifiers;

[0031] (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and

[0032] (c) Lactic acid;

[0033] Wherein, the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%.

[0034] In some embodiments, the mass ratio of component (c) to component (b) is 33-300:1. In some embodiments, the mass ratio of component (c) to component (a) is 0.5-7:1.

[0035] For example, the mass ratio (m) of component (c) to component (b) 成分(c) :m 成分(b) The ratio can be 31:1, 32:1, 33:1, 35:1, 40:1, 50:1, 60:1, 70:1, 80:1, 90:1, 100:1, 110:1, 120:1, 130:1, 140:1, 150:1, 160:1, 170:1, 180:1, 190:1, 200:1, 210:1, 220:1, 230:1, 240:1, 250:1, 260:1, 270:1, 280:1, 290:1, 300:1, or any range thereof.

[0036] The mass ratio (m) of component (c) and component (a) 成分(c) :m 成分(a) The ratio can be 0.5:1, 0.6:1, 0.7:1, 0.8:1, 0.9:1, 1:1, 1.5:1, 2:1, 2.5:1, 3:1, 3.5:1, 4:1, 4.5:1, 5:1, 5.5:1, 6:1, 6.5:1, 7:1 or any range between them.

[0037] According to this application, an emulsifier is a substance that can promote the emulsification of the dispersed phase and maintain its stability.

[0038] Non-limiting examples that may be mentioned include the following emulsifiers: ionic emulsifiers and nonionic emulsifiers. Ionic emulsifiers include anionic emulsifiers, cationic emulsifiers, and amphoteric emulsifiers; nonionic emulsifiers include polyethers, silicone oils, glycerol fatty acid esters, polyglycerol fatty acid esters, sorbitol, and sugar derivatives.

[0039] The emulsifier used to dissolve component (b) in a physiologically acceptable oily medium is a polyether fatty acid ester emulsifier. Therefore, the emulsifier in this application contains at least a polyether fatty acid ester emulsifier.

[0040] In some preferred embodiments, the polyether fatty acid ester emulsifier includes a polyethylene glycol fatty acid ester emulsifier.

[0041] In some preferred embodiments, the polyethylene glycol fatty acid ester emulsifier includes PEG-30 dimerized hydroxystearate and / or PEG-5 glyceryl stearate.

[0042] According to this application, component (b) is hyaluronic acid or a salt thereof and / or acetylated hyaluronic acid or a salt thereof.

[0043] Here, hyaluronic acid is an anionic, unsulfated glycosaminoglycan composed of at least one disaccharide unit, wherein the disaccharide is D-glucuronic acid and N-acetyl-D-glucosamine, and its molecular weight is between 400 Daltons and several million Daltons. The hyaluronic acid salt is preferably an alkali metal salt of hyaluronic acid, more preferably a sodium, potassium, magnesium, calcium, or zinc salt.

[0044] Here, acetylated hyaluronic acid is the substance obtained by acetylation of hyaluronic acid. The acetylated hyaluronic acid salt is preferably an alkali metal salt, more preferably a sodium salt, potassium salt, magnesium salt, calcium salt, or zinc salt.

[0045] In some preferred embodiments, the weight-average molecular weight of the hyaluronic acid or its salt is ≤10000 Da, more preferably 400-8500 Da.

[0046] For example, the weight average molecular weight of the hyaluronic acid or its salt is 10000 Da, 9500 Da, 9000 Da, 8500 Da, 8000 Da, 7500 Da, 7000 Da, 6500 Da, 6000 Da, 5500 Da, 5000 Da, 4500 Da, 4000 Da, 3500 Da, 3000 Da, 2500 Da, 2000 Da, 1500 Da, 1000 Da, 950 Da, 900 Da, 850 Da, 800 Da, 750 Da, 700 Da, 650 Da, 600 Da, 550 Da, 500 Da, 450 Da, 400 Da, or any range thereof.

[0047] In some preferred embodiments, the weight-average molecular weight of the acetylated hyaluronic acid or its salt is ≤100,000 Da, and more preferably 10,000-50,000 Da.

[0048] For example, the weight-average molecular weight of the acetylated hyaluronic acid or its salt is 100,000 Da, 95,000 Da, 90,000 Da, 85,000 Da, 80,000 Da, 75,000 Da, 70,000 Da, 65,000 Da, 60,000 Da, 55,000 Da, 50,000 Da, 45,000 Da, 40,000 Da, 35,000 Da, 30,000 Da, 25,000 Da, 20,000 Da, 15,000 Da, 10,000 Da, 9,500 Da, 9,000 Da, 85 00Da, 8000Da, 7500Da, 7000Da, 6500Da, 6000Da, 5500Da, 5000Da, 4500Da, 4000Da, 3500Da, 3000Da, 2500Da, 2000Da, 1500Da, 1000Da, 950Da, 900Da, 850Da, 800Da, 750Da, 700Da, 650Da, 600Da, 550Da, 500Da, 450Da, 400Da or any range between them.

[0049] In this application, no restrictions are placed on the method for determining the weight-average molecular weight of component (b). Those skilled in the art can use conventional methods in the art to determine it. For example, for the components in the composition in this application, component (b) can be obtained by aqueous extraction using conventional methods in the art, and then the weight-average molecular weight of component (b) can be determined by conventional methods in the art, such as chromatography coupled with mass spectrometry or multi-angle laser light scattering coupled with size exclusion chromatography.

[0050] In some embodiments, component (a) is 0.5-10% by mass, component (b) is 0.001-1%, and component (c) is 0.1-9% by mass percentage in the composition. For example, component (a) can be 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, or any range thereof by mass percentage in the composition.

[0051] The component (b) can be 0.001%, 0.005%, 0.01%, 0.05%, 0.1%, 0.5%, 1%, or any range thereof;

[0052] The component (c) can be 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, or any range thereof.

[0053] According to this application, the physiologically acceptable oily medium includes non-volatile oils that are solid or semi-solid at room temperature and pressure.

[0054] Non-volatile oils are solid or semi-solid oils that do not exhibit volatility at room temperature (25°C) and normal pressure. Examples of non-volatile oils include hydrocarbon oils and waxes, waxes, esters, higher fatty acids, and higher fatty alcohols.

[0055] Examples of hydrocarbon oils and waxes include petrolatum, paraffin wax, microcrystalline wax, and ceresin wax.

[0056] Examples of waxes include beeswax, carnauba wax, candelilla wax, lanolin, whale wax, and wood wax.

[0057] Examples of esters include glyceryl monostearate and jojoba ester.

[0058] Examples of high-grade fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, and shea butter.

[0059] Examples of higher fatty alcohols include cetyl alcohol, stearyl alcohol, cetearyl alcohol, betaine alcohol, and lanolin alcohol.

[0060] In some embodiments, the content of the non-volatile oil that is solid or semi-solid at room temperature and pressure is 80-99% by mass percentage in the composition, and the amount added can be adjusted accordingly based on the amount of liquid oil and fat-soluble components added.

[0061] For example, the content of the non-volatile oil that is solid or semi-solid at room temperature and pressure, based on its mass percentage in the composition, is 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or any range thereof.

[0062] Furthermore, the physiologically acceptable oily medium includes non-volatile oils that are liquid at room temperature and pressure. Examples include mineral oil, squalane, hydrogenated polyisobutylene, polydimethylsiloxane, dimethylsiloxane, bis-aminopropyl polydimethylsiloxane, cyclopentamethoxysiloxane, triglycerides (ethylhexanoate), caprylic / capric triglycerides, isononyl isononanoate, hydrogenated olive oil, horse fat (horse oil), argan kernel oil, rice bran oil, macadamia seed oil, coconut oil, jojoba seed oil, ceramide, isopropyl palmitate, etc.

[0063] In some embodiments, the compositions of this application may also include fat-soluble active ingredients, such as vitamin E, coenzyme Q10, lycopene, phytosterols, etc.

[0064] In some embodiments, the compositions of this application may also include fat-soluble excipients, such as fat-soluble solubilizers, fat-soluble preservatives, etc.

[0065] The aforementioned substances can be used in a preferred manner to facilitate the formation of a transparent and homogeneous liquid.

[0066] In some embodiments, the oily composition comprises, in a physiologically acceptable oily medium,: (a) at least one emulsifier selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and (c) lactic acid; wherein the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%. In some embodiments, the mass ratio of component (c) to component (b) is 33-300:1. In some embodiments, the weight-average molecular weight of the hyaluronic acid or its salt is ≤10000 Da. In some embodiments, the weight-average molecular weight of the acetylated hyaluronic acid or its salt is ≤100000 Da.

[0067] In some embodiments, the oily composition comprises, in a physiologically acceptable oily medium, (a) at least one emulsifier selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and (c) lactic acid; wherein the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%. In some embodiments, the mass ratio of component (c) to component (b) is 33-300:1. In some embodiments, the weight-average molecular weight of the hyaluronic acid or its salt is 400-8500 Da. In some embodiments, the weight-average molecular weight of the acetylated hyaluronic acid or its salt is 10000-50000 Da.

[0068] In some embodiments, the oily composition comprises, in a physiologically acceptable oily medium,: (a) at least one emulsifier selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and (c) lactic acid; wherein the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%. In some embodiments, the mass ratio of component (c) to component (b) is 33-300:1. In some embodiments, the mass ratio of component (c) to component (a) is 0.5-7:1. In some embodiments, the weight-average molecular weight of the hyaluronic acid or its salt is ≤10000 Da. In some embodiments, the weight-average molecular weight of the acetylated hyaluronic acid or its salt is ≤100000 Da.

[0069] In some embodiments, the oily composition comprises, in a physiologically acceptable oily medium, (a) at least one emulsifier selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and (c) lactic acid; wherein the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%. In some embodiments, the mass ratio of component (c) to component (b) is 33-300:1. In some embodiments, the mass ratio of component (c) to component (a) is 0.5-7:1. In some embodiments, the weight-average molecular weight of the hyaluronic acid or its salt is 400-8500 Da. In some embodiments, the weight-average molecular weight of the acetylated hyaluronic acid or its salt is 10000-50000 Da.

[0070] In some embodiments, the oily composition comprises, in a physiologically acceptable oily medium,: (a) at least one emulsifier selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and (c) lactic acid; wherein the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%. In some embodiments, the weight-average molecular weight of the hyaluronic acid or its salt is ≤10000 Da. In some embodiments, the weight-average molecular weight of the acetylated hyaluronic acid or its salt is ≤100000 Da.

[0071] In some embodiments, the oily composition comprises, in a physiologically acceptable oily medium, (a) at least one emulsifier selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and (c) lactic acid; wherein the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%. In some embodiments, the weight-average molecular weight of the hyaluronic acid or its salt is 400-8500 Da. In some embodiments, the weight-average molecular weight of the acetylated hyaluronic acid or its salt is 10000-50000 Da.

[0072] In some embodiments, the oily composition comprises, in a physiologically acceptable oily medium,: (a) at least one emulsifier selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and (c) lactic acid; wherein the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%. In some embodiments, the component (a) is 0.5-10% by mass percentage, the component (b) is 0.001-1%, and the component (c) is 0.1-9%.

[0073] In some embodiments, the oily composition comprises, in a physiologically acceptable oily medium, (a) at least one emulsifier selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and (c) lactic acid; wherein the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%. In some embodiments, the weight-average molecular weight of the hyaluronic acid or its salt is ≤10000 Da. In some embodiments, the weight-average molecular weight of the acetylated hyaluronic acid or its salt is ≤100000 Da. In some embodiments, the component (a) is 0.5-10% by mass percentage in the composition, the component (b) is 0.001-1%, and the component (c) is 0.1-9%.

[0074] In some embodiments, the oily composition comprises, in a physiologically acceptable oily medium, (a) at least one emulsifier selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and (c) lactic acid; wherein the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%. In some embodiments, the weight-average molecular weight of the hyaluronic acid or its salt is 400-8500 Da. In some embodiments, the weight-average molecular weight of the acetylated hyaluronic acid or its salt is 10000-50000 Da. In some embodiments, by mass percentage in the composition, component (a) is 0.5-10%, component (b) is 0.001-1%, and component (c) is 0.1-9%.

[0075] In some embodiments, the oily composition comprises, in a physiologically acceptable oily medium,: (a) at least one emulsifier selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and (c) lactic acid; wherein the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%. In some embodiments, the mass ratio of component (c) to component (b) is 33-300:1. In some embodiments, the mass ratio of component (c) to component (a) is 0.5-7:1. In some embodiments, the weight-average molecular weight of the hyaluronic acid or its salt is ≤10000 Da. In some embodiments, the weight-average molecular weight of the acetylated hyaluronic acid or its salt is ≤100000 Da. In some embodiments, the component (a) is 0.5-10% by mass percentage in the composition, the component (b) is 0.001-1%, and the component (c) is 0.1-9%.

[0076] In some embodiments, the oily composition comprises, in a physiologically acceptable oily medium, (a) at least one emulsifier selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and (c) lactic acid; wherein the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%. In some embodiments, the mass ratio of component (c) to component (b) is 33-300:1. In some embodiments, the mass ratio of component (c) to component (a) is 0.5-7:1. In some embodiments, the weight-average molecular weight of the hyaluronic acid or its salt is 400-8500 Da. In some embodiments, the weight-average molecular weight of the acetylated hyaluronic acid or its salt is 10000-50000 Da. In some embodiments, the component (a) is 0.5-10% by mass percentage in the composition, the component (b) is 0.001-1%, and the component (c) is 0.1-9%.

[0077] In some embodiments, the oily composition comprises, in a physiologically acceptable oily medium,: (a) at least one emulsifier selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and (c) lactic acid; wherein the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%. In some embodiments, the mass ratio of component (c) to component (b) is 33-300:1. In some embodiments, the weight-average molecular weight of the hyaluronic acid or its salt is ≤10000 Da. In some embodiments, the weight-average molecular weight of the acetylated hyaluronic acid or its salt is ≤100000 Da. In some embodiments, the polyether fatty acid ester emulsifier includes polyethylene glycol fatty acid ester emulsifiers.

[0078] In some embodiments, the oily composition comprises, in a physiologically acceptable oily medium,: (a) at least one emulsifier selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and (c) lactic acid; wherein the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%. In some embodiments, the mass ratio of component (c) to component (b) is 33-300:1. In some embodiments, the weight-average molecular weight of the hyaluronic acid or its salt is ≤10000 Da. In some embodiments, the weight-average molecular weight of the acetylated hyaluronic acid or its salt is ≤100000 Da. In some embodiments, the polyether fatty acid ester emulsifier includes polyethylene glycol fatty acid ester emulsifiers. In some embodiments, the polyethylene glycol fatty acid ester emulsifier includes PEG-30 dimerized hydroxystearate and / or PEG-5 glyceryl stearate.

[0079] In some embodiments, the oily composition comprises, in a physiologically acceptable oily medium,: (a) at least one emulsifier selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and (c) lactic acid; wherein the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%. In some embodiments, the mass ratio of component (c) to component (b) is 33-300:1. In some embodiments, the weight-average molecular weight of the hyaluronic acid or its salt is 400-8500 Da. In some embodiments, the weight-average molecular weight of the acetylated hyaluronic acid or its salt is 10000-50000 Da. In some embodiments, the polyether fatty acid ester emulsifier includes polyethylene glycol fatty acid ester emulsifiers.

[0080] In some embodiments, the oily composition comprises, in a physiologically acceptable oily medium,: (a) at least one emulsifier selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and (c) lactic acid; wherein the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%. In some embodiments, the mass ratio of component (c) to component (b) is 33-300:1. In some embodiments, the weight-average molecular weight of the hyaluronic acid or its salt is 400-8500 Da. In some embodiments, the weight-average molecular weight of the acetylated hyaluronic acid or its salt is 10000-50000 Da. In some embodiments, the polyether fatty acid ester emulsifier includes polyethylene glycol fatty acid ester emulsifiers. In some embodiments, the polyethylene glycol fatty acid ester emulsifier includes PEG-30 dimerized hydroxystearate and / or PEG-5 glyceryl stearate.

[0081] In some embodiments, the oily composition comprises, in a physiologically acceptable oily medium,: (a) at least one emulsifier selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and (c) lactic acid; wherein the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%. In some embodiments, the mass ratio of component (c) to component (b) is 33-300:1. In some embodiments, the mass ratio of component (c) to component (a) is 0.5-7:1. In some embodiments, the weight-average molecular weight of the hyaluronic acid or its salt is ≤10000 Da. In some embodiments, the weight-average molecular weight of the acetylated hyaluronic acid or its salt is ≤100000 Da. In some embodiments, component (a) is 0.5-10% by mass percentage, component (b) is 0.001-1%, and component (c) is 0.1-9%. In some embodiments, the polyether fatty acid ester emulsifier includes a polyethylene glycol fatty acid ester emulsifier. In some embodiments, the polyethylene glycol fatty acid ester emulsifier includes PEG-30 dimerhydroxystearate and / or PEG-5 glyceryl stearate.

[0082] In some embodiments, the oily composition comprises, in a physiologically acceptable oily medium, (a) at least one emulsifier selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and (c) lactic acid; wherein the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%. In some embodiments, the mass ratio of component (c) to component (b) is 33-300:1. In some embodiments, the mass ratio of component (c) to component (a) is 0.5-7:1. In some embodiments, the weight-average molecular weight of the hyaluronic acid or its salt is 400-8500 Da. In some embodiments, the weight-average molecular weight of the acetylated hyaluronic acid or its salt is 10000-50000 Da. In some embodiments, component (a) is 0.5-10% by mass percentage, component (b) is 0.001-1%, and component (c) is 0.1-9%. In some embodiments, the polyether fatty acid ester emulsifier includes a polyethylene glycol fatty acid ester emulsifier. In some embodiments, the polyethylene glycol fatty acid ester emulsifier includes PEG-30 dimerhydroxystearate and / or PEG-5 glyceryl stearate.

[0083] In some embodiments, the oily composition comprises, in a physiologically acceptable oily medium,: (a) at least one emulsifier selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and (c) lactic acid; wherein the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%. In some embodiments, the mass ratio of component (c) to component (b) is 33-300:1. In some embodiments, the mass ratio of component (c) to component (a) is 0.5-7:1. In some embodiments, the weight-average molecular weight of the hyaluronic acid or its salt is ≤10000 Da. In some embodiments, the weight-average molecular weight of the acetylated hyaluronic acid or its salt is ≤100000 Da. In some embodiments, component (a) is 0.5-10% by mass percentage, component (b) is 0.001-1%, and component (c) is 0.1-9%. In some embodiments, the polyether fatty acid ester emulsifier includes a polyethylene glycol fatty acid ester emulsifier. In some embodiments, the polyethylene glycol fatty acid ester emulsifier includes PEG-30 dimerhydroxystearate and / or PEG-5 glyceryl stearate. In some embodiments, the physiologically acceptable oily medium includes non-volatile oils that are solid or semi-solid at room temperature and pressure. In some embodiments, the content of the non-volatile oils that are solid or semi-solid at room temperature and pressure is 80-99% by mass percentage in the composition.

[0084] In some embodiments, the oily composition comprises, in a physiologically acceptable oily medium, (a) at least one emulsifier selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and (c) lactic acid; wherein the mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%. In some embodiments, the mass ratio of component (c) to component (b) is 33-300:1. In some embodiments, the mass ratio of component (c) to component (a) is 0.5-7:1. In some embodiments, the weight-average molecular weight of the hyaluronic acid or its salt is 400-8500 Da. In some embodiments, the weight-average molecular weight of the acetylated hyaluronic acid or its salt is 10000-50000 Da. In some embodiments, component (a) is 0.5-10% by mass percentage, component (b) is 0.001-1%, and component (c) is 0.1-9%. In some embodiments, the polyether fatty acid ester emulsifier includes a polyethylene glycol fatty acid ester emulsifier. In some embodiments, the polyethylene glycol fatty acid ester emulsifier includes PEG-30 dimerhydroxystearate and / or PEG-5 glyceryl stearate. In some embodiments, the physiologically acceptable oily medium includes non-volatile oils that are solid or semi-solid at room temperature and pressure. In some embodiments, the content of the non-volatile oils that are solid or semi-solid at room temperature and pressure is 80-99% by mass percentage in the composition.

[0085] This application provides the use of the above composition in the preparation of skin care products or personal care products.

[0086] The skincare products mentioned are those applied directly to the skin's surface to achieve skincare and beauty effects. The personal care products mentioned are typically single-use or reusable paper products, such as tissues, diapers, nursing pads, or sanitary napkins.

[0087] According to this application, an example is that the oily composition described in this application is applied to the aforementioned paper to obtain personal care products.

[0088] In this application, no restrictions are placed on the coating amount of the composition; those skilled in the art can select an appropriate coating amount based on actual conditions. Similarly, no restrictions are placed on the coating method; those skilled in the art can use conventional methods in the field for coating. Those skilled in the art can adjust the coating amount and select a suitable coating method according to the type or size of the personal care product to be used.

[0089] This application provides a personal care product comprising any of the compositions described above.

[0090] In this application, no restrictions are placed on the amount of the composition used in personal care products, and those skilled in the art can make conventional selections based on needs.

[0091] Example

[0092] This application provides a general and / or specific description of the materials and test methods used in the experiments. In the following examples, unless otherwise specified, % represents wt%, i.e., weight percentage. Reagents or instruments used, unless otherwise specified, are all commercially available conventional reagent products. The materials used in the examples, comparative examples, and experimental cases are shown in Table 1.

[0093] Table 1

[0094] Example

[0095] In the preparation process, sodium hyaluronate is first dispersed in a polar solvent at room temperature and stirred for 10 minutes to form a visually uniform suspension (phase A). The emulsifier and oil are placed in the same container and heated to 80℃ + / - 3℃ until the mixture is completely melted, and then stirred for 10 minutes to form a visually uniform solution (phase B).

[0096] Phase A was heated to 80℃+ / -3℃ and mixed with Phase B at 80℃+ / -3℃. The mixture was homogenized at 80℃+ / -3℃ for 5 minutes and then stirred for 1 hour to obtain the final oily composition. The contents of each component are shown in Table 2.

[0097] Table 2

[0098] Verification Example

[0099] The prepared composition was placed in an oven at 80°C for 4 hours to observe whether particle precipitation or liquid stratification occurred. If no liquid stratification or particle precipitation occurred, the result was considered successful, as shown in Table 3. The appearance of mixtures numbered 1, 19, 20, and 27 are shown in Figures 1-4, respectively.

[0100] Table 3

[0101] As can be seen from Table 3 and Figures 1 to 4, the compositions obtained with numbers 1-18 are all transparent and homogeneous liquids after standing in an oven at 80°C for 4 hours, while the compositions obtained with numbers 19-27 are not transparent and homogeneous liquids after standing in an oven at 80°C for 4 hours.

[0102] The above description is merely a preferred embodiment of this application and is not intended to limit the application in any other way. Any person skilled in the art may make changes or modifications to the disclosed technical content to create equivalent embodiments. However, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of this application without departing from the scope of the technical solution of this application shall still fall within the protection scope of this application.

Claims

1. An oily composition comprising, in a physiologically acceptable oily medium: (a) at least one emulsifier, said at least one emulsifier being selected from polyether fatty acid ester emulsifiers; (b) at least one hyaluronic acid or a salt thereof, and / or acetylated hyaluronic acid or a salt thereof; and (c) Lactic acid; in, The mass ratio of component (c) to component (b) is >30:1, the mass ratio of component (c) to component (a) is <10:1, and the water content in the composition is <1%.

2. The composition according to claim 1, wherein, The mass ratio of component (c) to component (b) is 33-300:

1.

3. The composition according to claim 1 or 2, wherein, The mass ratio of component (c) to component (a) is 0.5-7:

1.

4. The composition according to any one of claims 1-3, wherein, The polyether fatty acid ester emulsifiers include polyethylene glycol fatty acid ester emulsifiers.

5. The composition according to claim 4, wherein, The polyethylene glycol fatty acid ester emulsifiers include PEG-30 dihydroxystearate and / or PEG-5 glyceryl stearate.

6. Use of the composition according to any one of claims 1-5 in the preparation of skin care products or personal care products.

7. A personal care product comprising the composition of any one of claims 1-5.

8. The application according to claim 6 or the personal care product according to claim 7, wherein, The personal care products include one or more of the following: tissues, diapers, nursing pads, and sanitary napkins.

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