Systems and methods for fabricating hydrogels with intrinsic vascular channels for liver tissue engineering
A 3D printed device with parallel channels and perfusion enhances cell viability and liver function, addressing integration challenges in bioartificial liver devices by improving mass transfer and vascular network integration.
WO2026050767A9 Publication Date: 2026-04-023D BIOLABS LLC
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Patent Information
- Application Number
- PCT/US2025/044505
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-08-30
- Filing Date
- 2025-09-02
- Publication Date
- 2026-04-02
AI Technical Summary
Technical Problem
Existing bioartificial liver devices face challenges in integrating vascular channel networks, limiting the scalability and effectiveness of tissue mass perfusion for therapeutic applications.
Method used
A 3D printed device with parallel hepatobiliary and portal-venous channels, perfused by a medium, enhances mass transfer and cell viability through a nanoporous hydrogel membrane, utilizing 3D printing, cell seeding, and perfusion techniques to mimic hepatic physiology.
Benefits of technology
The device improves cell viability and function, demonstrating enhanced liver-specific gene expression and histological features, with successful blood flow and cell maintenance in vivo, facilitating scalable tissue replacement.
✦ Generated by Eureka AI based on patent content.
Abstract
Disclosed are implantable devices, systems, and methods of fabricating, testing, optimizing, and / or implanting such devices. An implantable device includes a body, a first intrinsic channel network formed in the body and configured to receive cells, and a second intrinsic channel network formed in the body and configured to allow for active flow of a fluid to support viability and / or function of the cells in the first intrinsic channel network. The first intrinsic channel network comprises a first channel and the second intrinsic channel network comprises a second channel, with at least segments of the first and second channels parallel to and spaced apart from each other. Cells may be suspended in a collagen matrix and introduced to the first intrinsic channel network.
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