A personal care composition protecting from sun induced damages

Abstract

The present invention relates to a personal care composition. Particularly, the present invention relates to a personal care composition that provides protection from sun-induced damages. The composition comprises a skin care benefit agent selected from acetyl glutamic acid, acetyl glutamine, acetyl methionine, acetyl tyrosine, or a derivative, or a salt, or mixtures thereof, in combination with an oil-soluble sunscreen, a water-soluble sunscreen, and a non-ionic surfactant with select HLB value and select polymers. The composition provides protection from ROS generation induced by exposure to UV and / or blue light.

Description

[0001] A PERSONAL CARE COMPOSITION

[0002] Field of the invention

[0003] The present invention relates to a personal care composition. Particularly, the present invention relates to a personal care composition that provides protection from sun-induced damages.

[0004] Background of the invention

[0005] Solar radiation includes about 5% ultraviolet (UV) radiation, wavelength of which is between 200 nm and 400 nm. It is further divided into three regions: from 320 to 400 nm (UV-A), 280 to 320 nm (UV-B) and from 200 to 280 nm (UV-C). Substantial portion of UV-C radiation is absorbed by ozone. Scientific studies have indicated that exposure to UV-A and UV-B radiation for short period causes pigmentation, reddening of the skin and localized irritation, whereas continued or prolonged exposure can lead to sunburn, melanoma, formation of wrinkles and age spots. UV radiation is also thought to cause significant damage to hair. Studies have also indicated that exposure to UV also leads to generation of reactive oxygen species (ROS) and thereby exert oxidative stress. Therefore, it is desirable to protect the skin and other keratinous substrates of the human body from such harmful effects of both UV-A and UV-B radiation.

[0006] On the other hand, solar radiations also include visible spectrum, wavelength of which is between 400 to 700 nm which includes blue light (about 450 to 495 nm). Blue light amongst the visible spectrum is also reported to induce undesired effects e.g. ROS generation.

[0007] Several personal care / cosmetic compositions containing sunscreens are known.

[0008] US2022362127A1 (Unilever) relates to topical personal care compositions for improving cellular energy efficiency by protecting skin from mitochondrial fragmentation that takes place in the cells of an aging individual in need thereof. Use of a topical personal care composition comprising niacinamide and of one or more cooperative skin benefit agents for reducing cellular mitochondrial fragmentation, which cooperative agents are selected from the group consisting of 1 -methylnicotinamide chloride, N-acetylmethionine, mixtures thereof, and derivatives thereof. Use of niacinamide and cooperative skin benefit agent selected from 1- methylnicotinamide chloride, N-acetylmethionine, mixtures thereof, and derivatives thereof in the manufacture of a topical personal care composition for decreasing or preventing mitochondrial fragmentation in skin cells and for increasing skin cellular energy.

[0009] W02004060393A2 (Thorel Jean-Noel) relates to a cosmetic composition comprising a bioactive system which combines (i) a stable form in aqueous solution of ATP (adenosine-tri- phosphate) with optionally an ATP precursor, e.g. Gp4G (diguanosine tetraphosphate), or Ap4A (diadenosine tetraphosphate), and (ii) at least one biomimetic peptide comprising at most six amino acids, mimicking a cutaneous polypeptide or a cutaneous protein, or a biomolecule which is agonist or antagonist in relation to the aforementioned polypeptide or protein. According to the invention, the composition takes the form of a water-in-oil or oil-in- water emulsion, the bio-active system being included in the aqueous phase.

[0010] W02023030963A1 (Unilever) relates to a photoprotective personal care composition, which provides high sun-protection factor along with very good photostability and sensorial properties that the consumer expects when such a composition is applied on the skin. This is achieved through a composition comprising a combination of an oil-soluble sunscreen, a water-soluble sunscreen, a non-ionic surfactant having an HLB value in the range of 9 to 20, fatty acid, humectant; and a polymer selected from one of more of dimethicone / vinyldimethicone crosspolymer and hydrophobically modified silica.

[0011] However, a need still exists to provide compositions that protect the skin from sun-induced damages, particularly from oxidative stress / reactive oxygen species generation. Such ROS generation may be due to exposure to UV light or blue light.

[0012] It is thus an object of the present invention to provide for a personal care composition that provides protection from sun-induced damages, particularly from oxidative stress I generation of reactive oxygen species.

[0013] It is another object of the present invention to provide such personal care composition that, in addition, delivers desired sensorial attributes when applied on the skin e.g. moisturization, matte feel, easy spreadability and gentle on skin. It has now been found that when a personal care composition comprising a skin care benefit agent selected from acetyl glutamic acid, acetyl glutamine, acetyl methionine, acetyl tyrosine, or a derivative, or a salt, or mixtures thereof, were combined with an oil-soluble sunscreen, a -water soluble sunscreen and non-ionic surfactant having select HLB value and select polymers, protection from sun-induced damages, particularly from oxidative stress / ROS generation, was obtained. In addition, the desired sensorial attributes mentioned above were also obtained.

[0014] Summary of the invention

[0015] Accordingly, in the first aspect, the present invention relates to a personal care composition comprising:

[0016] (i) 0.0001 to 10 wt% of a skin care benefit agent selected from acetyl glutamic acid, acetyl glutamine, acetyl methionine, acetyl tyrosine, or a derivative, or a salt, or mixtures thereof,

[0017] (ii) 0.1 to 25 wt% of an oil-soluble sunscreen,

[0018] (iii) 0.1 to 5 wt% of a water-soluble sunscreen,

[0019] (iv) 0.1 to 5 wt% of a non-ionic surfactant having an HLB value in the range of 9 to 20, wherein the composition further comprises 0.25 to 5 wt% of a polymer selected from one or more of (a) dimethicone / vinyldimethicone crosspolymer and b) hydrophobically modified silica, wherein solubility of the oil-soluble sunscreen is less than 10 g / l, in water, at 25°C; and wherein solubility of the water-soluble sunscreen is higher than 10 g / l, in water, at 25°C.

[0020] Further, in a second aspect, the present invention relates to a method of protecting the skin from sun-induced damages comprising: a. applying the composition of the first aspect on to the skin; and b. optionally, rinsing the skin with water.

[0021] Further, in a third aspect, the present invention relates to use of the composition of the first aspect for providing protection from sun induced damages.

[0022] Further, in a fourth aspect, the present invention relates to use of a skin care benefit agent selected from acetyl glutamic acid, acetyl glutamine, acetyl methionine, acetyl tyrosine, or a derivative, or a salt, or mixtures thereof, in a personal care composition comprising an oil soluble sunscreen, a water soluble sunscreen and a nonionic surfactant having HLB value in the range from 9 to 20, for protecting skin from sun-induced damages.

[0023] Detailed description of the invention

[0024] These and other aspects, features and advantages will become apparent to those of ordinary skill in the art from reading of the following detailed description and the appended claims. For the avoidance of doubt, any feature of one aspect of the present invention may be utilized in any other aspect of the invention. The word "comprising" is intended to mean "including" but not necessarily "consisting of" or "composed of." In other words, the listed steps or options need not be exhaustive. It is noted that the examples given in the description below are intended to clarify the invention and are not intended to limit the invention to those examples per se. Unless specified otherwise, amounts as used herein are expressed in percentage by weight based on total weight of the composition and may be abbreviated as “wt%”. Except in the operating and comparative examples, or where otherwise explicitly indicated, all numbers in this description and claims indicating amounts of material or conditions of reaction, physical properties of materials and / or use are to be understood as modified by the word "about". Numerical ranges expressed in the format "x to y" are understood to include x and y. When for a specific feature multiple preferred ranges are described in the format "from x to y", it is understood that all ranges combining the different endpoints are also contemplated.

[0025] The composition of the invention is meant to be used for personal care or for cosmetic use and could also be referred to as a cosmetic composition. By “personal care composition” as used herein, is meant to include a composition for topical application to sun-exposed areas of the skin and / or hair of humans. Such a composition may be classified as leave-on or rinse off (also known as wash-off), and includes any product applied to a human body for improving appearance, cleansing, odor control or general aesthetics. The composition of the present invention can be in the form of a liquid, a lotion, a cream, foam, a stick or a gel. Non-limiting examples of such leave-on personal care compositions include skin lotions, creams, antiperspirants, deodorants, foundations, mascara, sunscreen lotions; and that of wash-off personal care compositions include face wash, hand I body wash compositions, shampoos, conditioners and shower gels. The composition of the present invention is preferably a leave- on composition. "Skin" as used herein is meant to include skin on the face and body (e.g., neck, chest, back, arms, underarms, hands, legs and scalp) and especially to the sun exposed parts thereof. Compositions of the invention are also of relevance to applications on any other keratinous substrates of the human body other than skin e.g. hair, where products may be formulated with the aim of improving photoprotection.

[0026] “Sun-induced damages” as used herein preferably means damages / potentially harmful effect e.g. ROS generation and thereby oxidative stress, occurring due to exposure to UV and / or blue light, contained in the sunlight.

[0027] In the first aspect, the present invention relates to a personal care composition comprising:

[0028] (i) 0.0001 to 10 wt% of a skin care benefit agent selected from acetyl glutamic acid, acetyl glutamine, acetyl methionine, acetyl tyrosine, or a derivative, or a salt, or mixtures thereof,

[0029] (ii) 0.1 to 25 wt% of an oil-soluble sunscreen,

[0030] (iii) 0.1 to 5 wt% of a water-soluble sunscreen,

[0031] (iv) 0.1 to 5 wt% of a non-ionic surfactant having an HLB value in the range of 9 to 20, wherein the composition further comprises 0.25 to 5 wt% of a polymer selected from one or more of (a) dimethicone / vinyldimethicone crosspolymer and b) hydrophobically modified silica, wherein solubility of the oil-soluble sunscreen is less than 10 g / l, in water, at 25°C; and wherein solubility of the water-soluble sunscreen is higher than 10 g / l, in water, at 25°C.

[0032] Skin care benefit agent

[0033] A composition as per the present invention (the composition) comprises a skin care benefit agent selected from acetyl glutamic acid (e.g., N-acetyl glutamic acid), acetyl glutamine (e.g., N-acetyl glutamine), acetyl methionine (e.g., N-acetyl methionine), acetyl tyrosine (e.g., N- acetyl tyrosine), and combinations thereof, including as a free acid, amide, ester, lactone, isomer, and any derivatives or salts thereof. Preferably, the skin care benefit agent is selected from acetyl methionine, or a derivative or a salt or mixture thereof. More preferably, acetyl methionine is selected as the skin care benefit agent. The term “derivative(s)” as used with reference to the skin care benefit agent as used herein refers to an amide, ester, ether, carboxyl, amino, acetyl, and / or alcohol forms of the particular ingredient. “Salts,” as used herein, includes but is not limited to ammonium, calcium, magnesium, manganese, potassium, sodium, tetraalkylammonium, trialkylammonium, and a combination thereof.

[0034] In a further aspect, the skin care benefit agent may be present in any of its isomeric forms and in combinations thereof. “Isomers,” as used herein, is meant to include D-isomers, L-isomers, and / or DL-isomers for a particular compound. Thus, the skin care benefit agent comprises its D-isomer form, L-isomer form, DL-isomer form, or a combination thereof.

[0035] For example, N-acetyl methionine may be present in any of its isomeric forms and in combinations thereof. For example, N-acetyl-DL-methionine (i.e., is in its DL-isomer form), N- acetyl-D-methionine (i.e., is in its D-isomer form) and N-acetyl-L-methionine (i.e., is in its L- isomer form).

[0036] The composition comprises the skin care benefit agent in an amount 0.0001 to 10 wt%, preferably 0.0005 to 8 wt%, preferably 0.001 to 6 wt%, preferably 0.005 to 5 wt%, preferably 0.01 to 4 wt%, preferably 0.02 to 3.5 wt%, preferably 0.025 to 3 wt%, preferably 0.05 to 2.5 wt%, preferably 0.1 to 2.5 wt%, preferably 0.1 to 2 wt%, preferably 0.2 to 1.5 wt%.

[0037] Acetyl methionine (or N-acetyl methionine), abbreviated as Acemet, is available from numerous suppliers, e.g. Sigma-Aldrich), has the following structure:

[0038] Oil-soluble sunscreen

[0039] The compositions comprise 0.1 to 25 wt% of an oil-soluble sunscreen. By ‘oil-soluble’, it is meant those organic sunscreens which have solubility in water less than 10 g / l, preferably less than 5 g / l, more preferably less than 2 g / l, at 25°C. Oil-soluble sunscreens could be of IIV-B type or of IIV-A type.

[0040] It is preferred that the composition comprises 0.1 to 20 wt%, preferably 1 to 15 wt%, preferably 3 to 12 wt%, preferably 5 to 10 wt% of a UVB oil soluble sunscreen. It is further preferred that the composition of the invention comprises 0.1 to 5 wt%, preferably 1 to 4 wt% of a UVA oil soluble sunscreen.

[0041] When an oil soluble UVB sunscreen is included, it is preferably one or more of octyl salicylate, 3,3,5-trimethylclohexyl 2-hydroxybenzoate, ethylhexyl salicylate, 2-ethylhexyl 2-cyano-3,3- diphenyl-2-propenoate which is also known as octocrylene, 2-ethylhexyl-4-methoxycinnamate or octylmethoxycinnamate, ethylhexyl triazone, 3-benzylidene camphor, cinoxate, diethylhexyl butamido triazone, para amino benzoic acid (PABA), ethyl dihydroxypropyl PABA, ethylhexyl dimethoxy benzylidene dioxoimidazoline propionate, isoamyl p-methoxycinnamate, isopentyl trimethoxycinnamate trisiloxane, isopropyl benzyl salicylate, isopropyl methoxycinnamate, 4- methylbenzylidene camphor, PEG-25 PABA, and pentyl dimethyl PABA. More preferred oilsoluble UVB sunscreens are selected from one or more of octyl salicylate, 3,3,5- trimethylclohexyl 2-hydroxybenzoate, ethylhexyl salicylate, 2-ethylhexyl 2-cyano-3,3- diphenyl-2-propenoate, and 2-ethylhexyl-4-methoxycinnamate and further more preferred are selected from one or more of 2-ethylhexyl-4-methoxycinnamate, ethylhexyl salicylate and 2- ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate. Some of the well known brands under which the above sunscreens are sold are Octisalate®, Homosalate®, Neo Heliopan®, Neo Heliopan® AV, Neo Heliopan® OS, Octocrylene® and Parsol® MCX. The oil-soluble UV-B sunscreen has Amax from 280 to 320 nm.

[0042] Composition of the invention may comprise an organic oil-soluble UVA sunscreen. When included, it is selected from one or more of a dibenzoylmethane compound, diethylamino hydroxybenzoyl hexyl benzoate and menthyl anthranilate. A dibenzoyl methane compound is most preferred for an oil-soluble UVA-sunscreen. Suitable dibenzoyl methane compounds are selected from one of more of t-butylmethoxy dibenzoylmethane, 2- methyldibenzoylmethane, 4-methyl-dibenzoyl-ethane, 4-isopropyldibenzoyl-methane, 4-tert- butyldibenzoylmethane, 2,4-dimethyldibenzoylmethane, 2,5-dimethyldibenzoylmethane, 4,4'- diisopropyl-dibenzoylmethane, 2-methyl-5-isopropyl-4'-methoxydibenzoylmethane, 2-methyl- 5-tert-butyl-4'-methoxy-dibenzoyl methane, 2,4-dimethyl-4'-methoxy dibenzoylmethane and 2,6-dimethyl-4-tert-butyl-4'-methoxy-dibenzoylmethane. The most preferred dibenzoyl methane compound is t-butylmethoxy dibenzoylmethane. Commercially available as Parsol 1789.

[0043] Composition of the invention may comprise both, an organic oil-soluble UVB and an organic oil-soluble UVA sunscreen selected from those described above. Alternately, there are certain oil soluble sunscreens which have both a UVA and UVB screening efficacy. It is selected from one or more bis-ethylhexyloxyphenol methoxyphenyl triazine, drometrizole trisiloxane, benzophenone and its derivatives. The most preferred one is bis-ethylhexyloxyphenol methoxyphenyl triazine, commercially available as Tinosorb S.

[0044] Water-soluble sunscreen

[0045] The composition of the invention comprises 0.1 to 5 wt% of a water-soluble sunscreen. Preferably, a water-soluble sunscreen is selected from a UV-A water-soluble sunscreen and / or a UV-B water-soluble sunscreen described below. By ‘water soluble’, it is meant those organic sunscreens which have solubility in water higher than 10 g / l, preferably higher than 50 g / l, at 25°C.

[0046] The preferred water-soluble UVB sunscreen for use in the present invention is phenyl benzimidazole sulphonic acid (PBSA), benzophenone-4 or benzylidene camphor sulfonic acid, preferably PBSA. PBSA also known as Ensulizole is commercially available as Eusolex 232 (from Merck KGaA). PBSA is also available under the brand names Neo Heliopan Hydro (from Symrise), Parsol HS (from DSM) and Sunsafe ES (from Uniproma). There are certain water-soluble sunscreens which have both a UVA screening efficacy as well as a UVB screening efficacy. Such sunscreens provide both UVA and UVB protection e.g. benzophenone-4 (sold as Sulisobenzone). However, for the purposes of the present invention benzophenone- 4 may be included as a water-soluble UV-B sunscreen.

[0047] The preferred UVA sunscreen for use in the present invention is one or more of disodium phenyl dibenzimidazole tetrasulfonate (Neoheliopan AP) or terephthalylidene dicamphor sulfonic acid (TDSA). Di sodium phenyl dibenzimidazole tetra sulfonate is also known as bisdisulizole disodium. This is commercially available as Neo heliopan AP (from Symrise Shanghai Ltd) or as Sunsafe DPDT (from Uniproma). Terephthalylidene dicamphor sulfonic acid (TDSA) is also known as Ecamsule. This is commercially available as Mexoryl SX (US4585597) by L’ Oreal or Sunsafe TDSA (from Uniproma). It can be used as parent acid or its salts to deliver the desired benefit.

[0048] The composition comprises 0.1 to 5 wt%, preferably 1 to 4 wt%, preferably 1.5 to 3 wt%, preferably 2 to 3 wt% of a water-soluble sunscreen described above.

[0049] The water-soluble sunscreens for inclusion in the composition of the present invention are generally commercially available in the acid form. When included in the composition in the acid form (pre-neutralized forms), i.e. having sulphonic acid group (-SO3H), the composition additionally comprises a neutralizing agent to convert the acid form into the salt form, in which form it is known to be active as a sunscreen with an exception to Mexoryl SX which can act as sunscreen with and without neutralization. When included, the neutralizing agent is preferably in amounts 0.05 to 4 wt%, more preferably 0.2 to 2 wt%. The neutralizing agent is preferably an inorganic or an organic alkali. Organic alkali is preferably an amine such as triethanolamine or diethanolamine. The present inventors have observed that the inorganic alkali is especially preferred. Preferred are alkali metal hydroxides. Most preferred metal hydroxide for inclusion as neutralizing agent in the composition of the invention are sodium hydroxide or potassium hydroxide.

[0050] Non-ionic surfactant

[0051] The composition of the invention comprises a non-ionic surfactant having an HLB value in the range of 9 to 20. More preferably the nonionic surfactant is selected from those having HLB value in the range 12 to 20, further more preferably 12 to 18.

[0052] HLB is calculated using the Griffin method wherein HLB = 20 x Mh / M wherein Mh is the molecular mass of the hydrophilic portion of the molecule and M is the molecular mass of the whole molecule, giving a result on an arbitrary scale of 0 to 20.

[0053] Preferably, the nonionic surfactant having HLB value in the range 9 to 20 is selected from one or more of fatty alcohol ethoxylates, fatty acid ethoxylate, alkyl phenol ethoxylates, and polyoxyethylene sorbitan alkyl esters. Examples of fatty alcohol ethoxylates that may be used as nonionic surfactants in the composition include polyoxyethylene lauryl ether (HLB= 16.9; commercially available as Brij® 35), polyoxyethylene (20) cetyl ether (HLB=16; commercially available as Brij® 58), polyethylene glycol octadecyl ether (HLB= 18.8; commercially available as Brij® 700) and Laureth - 9 (C12EO9; HLB=14.3; commercially available as Brij® L9).

[0054] Examples of alkyl phenol ethoxylates that may be used as nonionic surfactant in the composition include octylphenol ethoxylate (HLB=15.5; commercially available as Triton™ X165), octylphenol ethoxylate (HLB=17.6; commercially available as Triton™ X405) and octylphenol ethoxylate (HLB=18.4; commercially available as Triton™ X705).

[0055] Examples of polyoxyethylene sorbitan alkyl esters that may be used as the nonionic surfactant in the composition include polyoxyethylenesorbitan monolaurate (HLB=13.3; commercially available as Tween® 21), polyoxyethylenesorbitan monolaurate (HLB=16.7; commercially available as Tween® 20), Polyoxyethylenesorbitan monopalmitate (HLB=15.6; commercially available as Tween® 40) and polyoxyethylene sorbitan monostearate (HLB= 14.9; commercially available as Tween® 60).

[0056] Fatty acid ethoxylates are available under the Myrj class. Suitable examples of commercially available non-ionic surfactants for use in the composition of this class are Myrj S40 (PEG-40 stearate), Myrj S50 (PEG-50 stearate), or Myrj 59 (PEG-100 stearate).

[0057] Preferably, the composition comprises 0.2 to 5 wt%, more preferably 0.5 to 4 wt%, even more preferably from 1 to 3 wt% nonionic surfactant having HLB in the range 9 to 20.

[0058] A polymer

[0059] The composition further comprises 0.25 to 5 wt% of a polymer selected from one or more of (a) dimethicone / vinyldimethicone crosspolymer and b) hydrophobically modified silica. The dimethicone / vinyldimethicone crosspolymer could be with or without silica. Such polymers provided the desired sensory properties to the composition.

[0060] Various polymers of the above types could be used in the present invention. Dimethicone / vinyl dimethicone crosspolymer which is a preferred polymer as per the invention is available as KM-9729, DOWSIL™ EP-9215, SeraSnowSP 13, DOWSIL™9506 Powder, SpecsilSPD. An even more preferred polymer as per the invention is Dimethicone / Vinyl Dimethicone Crosspolymer (and) Silica which is available as DOWSIL™9701 Cosmetic Powder. Other suitable polymers which may be used are listed below:

[0061] Dimethicone / Vinyl Dimethicone Crosspolymer(and) Silica (and) Butylene Glycol available as DOWSIL™ EP-9801 Hydro Cosmetic Powder

[0062] Dimethicone (and) Dimethicone / Vinyl Dimethicone Crosspolymer(and) Dimethicone Crosspolymer(and) Beeswax (and) Silica (and) Silica Silylate available as DOWSIL™9576 Smooth Away Elastomer

[0063] Dimethicone / Vinyl Dimethicone Crosspolymer(and) Polymethylsilsesquioxane(and) Silica Dimethyl Silylate Available as SSP100

[0064] Dimethicone / Vinyl Dimethicone Crosspolymer(and) LauroylLysine available as DOWSIL™ EP-9289 LL

[0065] Hydrophobically modified silica is preferably selected from Silica Silylate available as DOWSIL™ VM-2270 AerogelFine Particles, HDK® H2000 and Silica dimethyl silylate available as HDK® H15, HDK® H20, HDK® H30, HDK® H18

[0066] Preferably, the composition comprises 0.5 to 4 wt%, more preferably 1 to 3 wt% e.g. 2 wt%, of the polymer described above.

[0067] Fatty acids

[0068] Preferably, the composition further comprises 3 to 25 wt% fatty acid. The fatty acid is preferably a C10 to C22 fatty acid, more preferably a C16 to C18 fatty acid. In other words, the composition preferably comprises a fatty acid selected from fatty acids having preferably 10 to 22, preferably 16 to 18, carbon atoms in the carbon chain. Examples of such fatty acid include capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid and behenic acid. Most preferably the fatty acids are stearic acid or palmitic acid or a mixture thereof. The fatty acid is often hystric acid which is substantially (generally about 90 to 95 %) a mixture of stearic acid and palmitic acid. Preferred hystric acid are ones having 40 to 65 wt% C16 and 34 to 58 wt% C18; or ones having 52 to 58 wt% C16 and 40 to 47 wt% C18 fatty acids.

[0069] It is particularly preferred that the composition comprises 4 to 23 wt%, more preferably 5 to 20 wt%, even more preferably 6 to 17 wt% fatty acid described above.

[0070] Preferably, the composition further comprises soap, a salt of fatty acids described above. Preferably, the soap is formed in-situ by addition of an alkaline agent e.g. sodium hydroxide, potassium hydroxide in amounts so that the amount of soap so formed is in the range from 0.1 to 10 wt%, preferably from 0.3 to 7 wt%, preferably from 1 to 5 wt%, preferably from 2 to 3 wt% in the composition. Examples of such soaps include sodium palmitate, sodium stearate, potassium palmitate, potassium stearate.

[0071] When the soap is present in combination with fatty acids described above, it provides a so- called vanishing effect, i.e. when a composition is applied on the skin, it vanishes into the skin without leaving the residue of composition so applied on the skin.

[0072] Humectants

[0073] Humectants of the polyhydric alcohol-type can be employed as cosmetically acceptable carriers. Preferably the humectant is at least one of propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol, sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1 ,3-butylene glycol, isoprene glycol, 1 ,2,6-hexanetriol, glycerol, ethoxylated glycerol, and propoxylated glycerol. Preferred humectants are selected from one or more of glycerol, sorbitol, propylene glycol and 1 ,3-butylene glycol. Glycerol is the most preferred humectant. It is preferred that the amount of humectant is 0.1 to 10 wt%, preferably 1 to 10 wt% more preferably 2 to 8 wt%, further more preferably 2 to 5 wt%.

[0074] Other polymers

[0075] The composition may optionally include other sensory modifying polymers other than those mentioned above in the form of spherical microporous particles. Preferred particles of this type are of the acrylate crosspolymer type. One especially preferred particle is available as Ganzpearl 820 GMP. It is preferably included in the composition to get a smooth creamy feel and to achieve high oil absorbency. Other polymeric particles which may be included are styrene / acrylates copolymer which are available under the brand name of SunSpheres™ Powder, SunSpheres™ PGL and SunSpheres™ LCG from Dow. Preferably, the composition comprises 0.1 to 2 wt%, preferably 0.5 to 2 wt% of these other polymers.

[0076] Preferably, the composition further comprises a thickener polymer other than those described above. The polymer acts as thickener in the composition and improves sensorial properties of the composition. The polymer is preferably selected from the following classes:

[0077] • acrylate I R-methacrylate copolymer e.g. acrylates / steareth-20 methacrylate copolymer (commercially available as AculynTM 22) and acrylates / beheneth-25 methacrylate copolymer (commercially available as AculynTM 28),

[0078] • acrylate I R-methacrylate crosspolymer e.g. acrylates / steareth-20 methacrylate crosspolymer (commercially available as AculynTM 88),

[0079] • acrylates copolymer (commercially available as AculynTM 33),

[0080] • acrylate / R-alkyl acrylate crosspolymer e.g. aery I ates / C 10-030 alkyl acrylate crosspolymer (commercially available as PemulenTM TR-2),

[0081] • copolymer of ammonium acryloyldimethyltaurate with vinyl pyrrolidone (commercially available as Aristoflex® AVC),

[0082] • copolymer of sodium acryloyldimethyltaurate with vinyl pyrrolidone (commercially available as Aristoflex® A VS); and

[0083] • crosspolymer of acryloyldimethyltaurate with R-alkyl acrylate and methyacrylate e.g. Ammonium acryloyldimethyltaurate / beheneth-25 methacrylate crosspolymer (commercially available as Aristoflex® HMB and Aristoflex® BLV); and mixtures thereof.

[0084] Alternatively, the composition may comprise cellulose-based thickeners such as hydroxyethyl cellulose, hydroxypropyl methyl cellulose and mixtures thereof. More preferably, the polymer is selected from acrylate I R-methacrylate copolymer, acrylates copolymer and mixtures thereof. Preferably, the composition comprises 0.1 to 5 wt%, more preferably 0.5 to 4.5 wt%, even more preferably 1 to 4 wt%, further more preferably from 1.5 to 3.5 wt%, still more preferably from 2 to 3 wt% of these thickener polymers.

[0085] Water

[0086] Water is preferably included in amounts 35 to 90 wt%, more preferably 50 to 85 wt%, further more preferably 50 to 80 wt% in the composition. Preferably, the composition further comprises an emollient. These may be in the form of silicone oils, ester emollients, and hydrocarbons. Amounts of the emollients may range anywhere from 0.1 to 25 wt%, preferably between 1 and 10 wt%.

[0087] Silicone oils may be divided into the volatile and nonvolatile variety. The term "volatile" as used herein refers to those materials which have a measurable vapor pressure at ambient temperature. Volatile silicone oils are preferably chosen from cyclic (cyclomethicone) or linear polydimethylsiloxanes containing from 3 to 9, preferably from 5 to 6, silicon atoms.

[0088] Nonvolatile silicone oils useful as an emollient material include polyalkyl siloxanes, polyalkylaryl siloxanes and polyether siloxane copolymers. The essentially nonvolatile polyalkyl siloxanes useful herein include, for example, polydimethyl siloxanes with viscosities of from 5 x 10"6to 0.1 m2 / s at 25 °C. Among the preferred nonvolatile emollients useful in the present compositions are the polydimethyl siloxanes having viscosities from 1 x 105to 4 x 104m2 / s at 25 °C.

[0089] Another class is of ester emollients, which are alkyl esters of saturated fatty acids having 10 to 24 carbon atoms. Examples thereof include behenyl neopentanoate, isononyl isonanonoate, isopropyl myristate and octyl stearate. Alternatively, they are ether-esters such as fatty acid esters of ethoxylated saturated fatty alcohols. Further alternatively they are polyhydric alcohol esters such as ethylene glycol mono and di-fatty acid esters, diethylene glycol mono- and di-fatty acid esters, polyethylene glycol (200-6000) mono- and di- fatty acid esters, propylene glycol mono- and di-fatty acid esters, polypropylene glycol 2000 monostearate, ethoxylated propylene glycol monostearate, glyceryl mono- and di-fatty acid esters, polyglycerol poly-fatty esters, ethoxylated glyceryl mono-stearate, 1 ,3-butylene glycol monostearate, 1 ,3-butylene glycol distearate, polyoxyethylene polyol fatty acid ester, sorbitan fatty acid esters, and polyoxyethylene sorbitan fatty acid esters are satisfactory polyhydric alcohol esters. Particularly useful are pentaerythritol, trimethylolpropane and neopentyl glycol esters of C1-C30 alcohols. Alternatively there are wax esters such as beeswax, spermaceti wax and tribehenin wax. Further alternatively, they are sugar esters of fatty acids such as sucrose polybehenate and sucrose polycottonseedate. Further alternatively they are ester emollients principally based upon mono-, di- and tri- glycerides. Representative glycerides include sunflower seed oil, cottonseed oil, borage oil, borage seed oil, primrose oil, castor and hydrogenated castor oils, rice bran oil, soybean oil, olive oil, safflower oil, shea butter, jojoba oil and combinations thereof. Amounts of such esters may range from 0.1 to 20 wt%. Another example of emollients include lanolin oil and lanolin derivatives.

[0090] Hydrocarbons, which are suitable cosmetically acceptable carriers include petrolatum, mineral oil, C8-Ci8 isoparaffins, polybutenes and especially isohexadecane, available commercially as Permethyl® 101 A from Presperse Inc.

[0091] Fatty alcohols having from 10 to 30 carbon atoms are another useful category of cosmetically acceptable carrier. Illustrative of this category are stearyl alcohol, lauryl alcohol, myristyl alcohol, oleyl alcohol and cetyl alcohol and mixtures thereof. Thickeners can be utilized as part of the cosmetically acceptable carrier of compositions according to the present invention. Typical thickeners include crosslinked acrylates (e.g. Carbopol® 982 and Carbopol® llltrez 10), hydrophobically-modified acrylates (e.g. Carbopol 1382(R)). Inorganics may also be utilized as thickeners, particularly clays such as bentonites and hectorites, fumed silicas, talc, calcium carbonate and silicates such as magnesium aluminum silicate (Veegum®). Amounts of the thickener may range from 0.0001 to 10 wt%, usually from 0.001 to 2.5 wt%, optimally from 0.01 to 1 wt%. Preferred are emollients that can be used, especially for products intended to be applied to the face, to improve sensory properties and are chosen from the group of oils that do not form stiff gels with 12HSA; these include polypropylene glycol-14 butyl ether otherwise known as Tegosoft® PBE, or PPG15 stearyl ether such as Tegosoft® E, other oils such as esters, specifically, isopropyl myristate, isopropyl palmitate, other oils could include castor oils and derivatives thereof.

[0092] The inventive compositions preferably include a skin brightening compound. Illustrative substances are lactic acid, niacinamide, vitamin C or derivatives thereof, arbutin, kojic acid, ferulic acid, hydroquinone, resorcinol and derivatives including 4-substituted resorcinols and combinations thereof. More preferably, selected from the group consisting of kojic acid, hydroquinone and 4-substituted resorcinol. Also, dicarboxylic acids represented by the formula HOOC-(CxHy)-COOH where x=4 to 20 and y=6 to 40 such as azelaic acid, sebacic acid, oxalic acid, succinic acid, fumaric acid, octadecenedioic acid or their salts or a mixture thereof, most preferably fumaric acid or salt thereof, especially di-sodium salt. Combination of 12HSA with fumaric acid or salts thereof are particularly preferred, especially for skin brightening formulations. Amounts of these skin brightening compounds may range from 0.1 to 10 wt%, preferably from 0.5 to 2 wt%. It is preferred that the skin brightening active may also be selected from nicotinic acid esters, non-vasodilating esters of nicotinic acid, nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N-oxide, niacinamide N-oxide and mixtures thereof.

[0093] Another preferred ingredient of the inventive compositions is a retinoid. As used herein, "retinoid" includes all natural and / or synthetic analogs of Vitamin A or retinol-like compounds which possess the biological activity of Vitamin A in the skin as well as the geometric isomers and stereoisomers of these compounds. The retinoid is preferably retinol, retinol esters (e.g., C2 -C22 alkyl esters of retinol, including retinyl palmitate, retinyl acetate, retinyl propionate), retinal, and / or retinoic acid (including all-trans retinoic acid and / or 13-cis-retinoic acid), more preferably retinoids other than retinoic acid. These compounds are well known in the art and are commercially available from a number of sources, e.g., Sigma Chemical Company (St. Louis, Mo.), and Boerhinger Mannheim (Indianapolis, Ind.). Preferred retinoids are retinol, retinyl palmitate, retinyl acetate, retinyl propionate, retinal and combinations thereof. The retinoid is preferably substantially pure, more preferably essentially pure.

[0094] Colorants, opacifiers and abrasives may also be included in compositions of the present invention. Each of these substances may range from 0.05 to 5 wt%, preferably between 0.1 and 3 wt% in the composition.

[0095] Preservatives could be incorporated into the compositions of this invention to protect against the growth of potentially harmful microorganisms. Suitable traditional preservatives for compositions of this invention are alkyl esters of para-hydroxybenzoic acid. Other preservatives which have come into use include hydantoin derivatives, propionate salts, and a variety of quaternary ammonium compounds. Cosmetic chemists are familiar with appropriate preservatives and routinely choose them to satisfy the preservative challenge test and to provide product stability. Particularly preferred preservatives are iodopropynyl butyl carbamate, phenoxyethanol, caprylyl glycol, C1-6 parabens (especially, methyl paraben and / or propyl paraben), imidazolidinyl urea, sodium dehydroacetate and benzyl alcohol. The preservatives should be selected having regard for the use of the composition and possible incompatibilities between the preservatives and other ingredients in the emulsion. Preservatives are preferably employed in amounts ranging from 0.01 to 2 wt% in the composition. An especially preferred combination is octocrylene and caprylyl glycol, since caprylyl glycol has been disclosed to enhance UVA and UVB protection. The compositions of the present invention can comprise a wide range of other optional components. The CTFA Cosmetic Ingredient Handbook, Second Edition, 1992, which is incorporated by reference herein in its entirety, describes a wide variety of non-limiting cosmetic and pharmaceutical ingredients commonly used in the skin care industry, which are suitable for use in the compositions of the present invention. Examples include antioxidants, binders, biological additives, buffering agents, colorants, astringents, fragrance, opacifying agents, conditioners, exfoliating agents, pH adjusters, essential oils, skin sensates, skin soothing agents and skin healing agents.

[0096] The compositions of the present invention are preferably non-solid. The compositions of the invention are preferably leave-on compositions. Such compositions are applied on the skin and remain thereon for prolonged time. Rather, as leave-on compositions are not intended to be rinsed-off they need to be non-irritating and therefore it would be necessary to minimize the total level of surfactant and the total level of anionic surfactant in leave-on compositions. The total level of anionic surfactant in the inventive compositions is preferably no more than 10 %, more preferably below 8 %, most preferably at most 5 %, optimally at most 3 %.

[0097] Further, in a second aspect, the present invention relates to a method of protecting the skin from sun-induced damages comprising: a. applying the composition of the first aspect to the skin; and b. optionally, rinsing the skin with water.

[0098] Preferably, the use is non-therapeutic or cosmetic in nature.

[0099] It has been found that the composition of the present invention protects the skin from sun- induced damages, e.g. from oxidative stress exerted I created due to generation of ROS. Thus, in a way, the present invention, in this second aspect, preferably relates to a method of protecting the skin from sun-induced oxidative stress, wherein the method comprises: a. applying the composition of the first aspect to the skin; and b. optionally, rinsing the skin with water.

[0100] Preferably, the use is non-therapeutic or cosmetic in nature. In another preferred aspect, the present invention relates to the composition of the first aspect wherein the skin is protected from sun-induced damages e.g. oxidative stress, by: a. applying the composition of the first aspect to the skin; and b. optionally, rinsing the skin with water.

[0101] Preferably, the use is non-therapeutic or cosmetic in nature.

[0102] In aspects described above, the method further comprises an optional step, step b., where the skin is rinsed with water. If carried out, because of step b., the composition so applied in the preceding step a., is removed as the skin is rinsed with water. If carried out, the step b., may be carried out within 30 minutes, preferably within 25 minutes, preferably within 20 minutes, preferably within 15 minutes, preferably within 10 minutes, preferably within 5 minutes, preferably within 1 minute from carrying out the step a. Such step b, is carried out if the composition is formulated as a wash-off composition. Preferably, the method is non- therapeutic or cosmetic in nature.

[0103] In use, a small quantity of the composition, for example from 1 to 5 ml, is applied to exposed area of the skin, from a suitable container or applicator and, if necessary, it is then spread over and / or rubbed into the skin using the hand or fingers or a suitable device.

[0104] Further, in a third aspect, the present invention relates to use of the composition of the first aspect for providing protection from sun-induced damages. Preferably, the use is non- therapeutic or cosmetic in nature.

[0105] In another preferred aspect, the present invention relates to the composition of the first aspect for use in providing protection from sun-induced damages, e.g. from oxidative stress exerted I created due to generation of ROS.

[0106] In a fourth aspect, the present invention relates to use of a skin care benefit agent selected from acetyl glutamic acid, acetyl glutamine, acetyl methionine, acetyl tyrosine, or a derivative, or a salt, or mixtures thereof, in a personal care composition comprising an oil soluble sunscreen, a water soluble sunscreen and a nonionic surfactant having HLB value in the range from 9 to 20, wherein the composition further comprises 0.25 to 5 wt% of a polymer selected from one or more of (a) dimethicone / vinyldimethicone crosspolymer and b) hydrophobically modified silica, for protecting skin from sun-induced damages. Preferably, the use is non- therapeutic or cosmetic in nature.

[0107] The individual Sun Protection Factor (SPF) for each subject is defined as the ratio of the amount of energy (dose, in units of J / m2or in seconds of exposure time) required to produce minimal erythema on protected skin to the amount of energy needed to produce minimal erythema on untreated skin calculated as follows:

[0108] SPF = MED Protected Skin

[0109] MED Unprotected Control Site

[0110] The SPF for the product is calculated by taking the arithmetic mean of the individual SPF values for all the subjects.

[0111] While the above summarizes the present invention, it will become apparent to those skilled in the art that modifications, variations and alterations may be made without deviating from the scope and spirit of the present invention as described and claimed herein. The invention will now be further illustrated in the following non-limiting examples.

[0112] Examples

[0113] Preparation of compositions

[0114] The compositions of examples A to C (control) and a composition of example 1 (as per the present invention), as shown in table 1 below, were prepared as follows:

[0115] The polymers Ultrez 10 and xanthan gum were pre-dispersed in water in a separate beaker. The oil phase ingredients such as fatty acid mix, non-ionic surfactant, emollients, and oilsoluble sunscreens were added to a glass beaker and melted at 75°C. If needed, the sensory agents DC 9701 and Ganzpearl 820 were pre-dispersed in the molten oil phase before adding to emulsification process. The water-soluble sunscreens were pre-neutralized in a separate beaker using alkali (NaOH or KOH) in water. In the main container, glycerine and water were homogenized at 75°C. The pre-neutralized water-soluble sunscreens were added and were homogenized. After homogenization, the molten oil phase was added to the main container and homogenization was continued. After complete mixing, the pre-dispersed polymers were added and neutralized as required. After complete mixing, other ingredients e.g. Acemet, that was pre-neutralized with 0.1 N KOH, was added at 45°C.

[0116] Cell culture and exposure to UV or blue light

[0117] Keratinocytes (HaCaT cells) were seeded in 48-well plates at a density of 3.5 x 104cells / well and were maintained in the DMEM medium reconstituted as described above, for 24 to 48 h. The cells were exposed to UV light using a Solar simulator comprising a Xenon arc lamp and to blue light using LED source, as required. Cells that were not exposed either to UV or to blue light, were used as control. Prior to exposure, compositions (as shown in table 1 below) were applied evenly on a PMMA plate (2 mg / cm2). For the UV / Blue light exposure, the media was carefully removed, and the cells were gently washed with sterile 1X Phosphate buffered saline (PBS). Exposure was carried out with a PMMA plate on top of the culture plate with a lid and minimal levels of 1X PBS coating the cell layer. After exposure, PBS was removed and replaced with the media in all wells. To mimic the penetration of either Acemet or N-acetyl glutamic acid or N-acetyl tyrosine into the skin, cells were treated with media containing either Acemet or N-acetyl glutamic acid or N-acetyl tyrosine, as shown in tables below. Plates were incubated in 5% CC>2 / 37OC incubator for 6 h and post incubation, cells were harvested and measured ROS level by DCFDA assay.

[0118] DCFDA Assay

[0119] Post 6 h, cells were washed with 1X PBS and treated with media containing DCFDA reagent and incubated at 37°C in the CO2 incubator for 30 minutes. Then cells were washed with 1x PBS once followed by the addition of fresh PBS. The plates were then wrapped with aluminum foil and taken reading at an excitation wavelength of 485 nm and emission wavelength of 535 nm. The amount of ROS generated was calculated as percentage control after background subtraction.

[0120] SPF and UVAPF Measurements

[0121] The invitro SPF and UVAPF values for the samples shown in table 4 below were measured using the following procedure:

[0122] Thin film transmittance measurements were done using Labsphere’s Ultraviolet transmittance analyzer. In this study, 70 x 70 mm PMMA plate with ~6 pm roughness from Schonberg GmbH & Co were used. The percent transmittance of the various compositions was measured using a procedure as outlined below. 2 mg / cm2of sample was applied on PMMA plate, distributed uniformly using a syringe, and spread uniformly. The drying time for the PMMA plates was 30 minutes. After the drying time, sample plates were exposed to UV light and transmittance scan was recorded. This scan gives the transmittance as a function of wavelength (290 - 400 nm) for a given sample. For a single plate six to nine different spots were scanned. The same was repeated for 2 or 3 plates. The data reported is thus an average over 12 -18 readings. The reference transmittance scan was obtained using a blank plate, with no sample on the PMMA plates with glycerin spread on it. The transmittance values were used to arrive at the SPF values using the UV -2000s application provided with the instrument.

[0123] Table 1 :

[0124] Further, SPF and LIVAPF measurements of these compositions were carried as described earlier and were found the be as shown in table 2 below. Table 2: SPF and UVAPF

[0125] The data in table 2 above shows that the composition as per the present invention (example 1) shows improved SPF as well as UVAPF when compared to controls.

[0126] Further, using the compositions as shown in table 1 above, ROS were measured using the DCFDA assay described earlier. ROS data was found to be as shown in table 3 below.

[0127] Table 3: ROS percentage upon exposure to UV (100 mJ / cm2)

[0128] For ROS measurements shown in table 3 above, compositions of examples A, B, C and 1 were applied on to the PMMA plate. However, for examples B and 1 , N-acetyl-DL-methionine was added to cells to mimic penetration thereof into the skin as described earlier.

[0129] The data in table 3 above showed that when the composition as per the present invention(the composition of example 1 above) was used, it protected the cells from sun-induced damage, e.g. oxidative stress. The data showed that when the composition of the present invention was used, the ROS levels were reduced and were found to be tended towards that of cells that were not exposed to UV.

[0130] Further, the following compositions were prepared as described earlier: Table 4: The SPF and LIVAPF of compositions of examples 3 and 4 were measured as described earlier; and were found to be as shown in table 5 below:

[0131] Table 5:

[0132] Further, ROS were measured using the DCFDA assay described above; and were found to be as shown in table 6 below.

[0133] Table 6: ROS percentage upon exposure to UV (100 mJ / cm2) [Note: Untreated cells (no exposure to UV) were taken as control with ROS= 100%]

[0134] For ROS measurements shown in table 6 above, compositions of example A1 , B1 , C1 and 2 were applied on to the PMMA plate. However, for examples B1 and 2, N-acetyl-glutamic acid was added to cells to mimic penetration thereof into the skin as described earlier.

[0135] Further, ROS were measured using the DCFDA assay described above; and were found to be as shown in table 7 below.

[0136] Table 7: ROS percentage upon exposure to UV (100 mJ / cm2)

[0137] For ROS measurements shown in table 7 above, compositions of example A1 , B2, C1 and 3 were applied on to the PMMA plate. However, in case of examples B2 and 3, N-acetyl tyrosine was added to cells to mimic penetration thereof into the skin as described earlier.

Claims

Claims1. A personal care composition comprising:(i) 0.0001 to 10 wt% of a skin care benefit agent selected from acetyl glutamic acid, acetyl glutamine, acetyl methionine, acetyl tyrosine, or a derivative, or a salt, or mixtures thereof,(ii) 0.1 to 25 wt% of an oil-soluble sunscreen,(iii) 0.1 to 5 wt% of a water-soluble sunscreen,(iv) 0.1 to 5 wt% of a non-ionic surfactant having an HLB value in the range of 9 to 20, wherein the composition further comprises 0.25 to 5 wt% of a polymer selected from one or more of (a) dimethicone / vinyldimethicone crosspolymer and b) hydrophobically modified silica, wherein solubility of the oil-soluble sunscreen is less than 10 g / l, in water, at 25°C; and wherein solubility of the water-soluble sunscreen is higher than 10 g / l, in water, at 25°C.

2. The composition as claimed in claim 1 wherein the skin care benefit agent is selected from acetyl methionine, or a derivative or a salt or mixtures thereof.

3. The composition as claimed in claims 1 or 2 wherein the skin care benefit agent is acetyl methionine.

4. The composition as claimed in any one of claims 1 to 3 wherein the composition further comprises 3 to 25 wt% of a C10-C22 fatty acid.

5. A composition as claimed in claim 4 wherein the fatty acid is selected from one or more of stearic acid and palmitic acid, preferably a mixture of stearic acid and palmitic acid.

6. The composition as claimed in any one of claims 1 to 5 wherein the composition further comprises 0.1 to 10 wt% humectant.

7. A composition as claimed in any one of claims 1 to 6 wherein the oil-soluble sunscreen is chosen either from a IIV-B sunscreen selected from one or more of octyl salicylate, 3,3,5-trimethylclohexyl 2- hydroxy benzoate, ethylhexyl salicylate, 2-ethylhexyl 2-cyano- 3,3-diphenyl-2-propenoate, 2-ethylhexyl-4-methoxycinnamate andoctylmethoxycinnamate; and / or from a IIV-A sunscreen selected from one or more of a dibenzoylmethane compound, diethylamino hydroxy benzoyl hexyl benzoate and menthyl anthranilate.

8. A composition as claimed in claim 7 wherein the dibenzoylmethane compound is selected from one or more of t-butylmethoxydibenzoylmethane, 2- methyldibenzoylmethane, 4-methyl-dibenzoylmethane, 4-isopropyldibenzoyl-methane, 4-tert-butyldibenzoylmethane, 2,4-dimethyldibenzoylmethane, 2,5- dimethyldibenzoylmethane, 4,4'-diisopropyl-dibenzoylmethane, 2-methyl-5-isopropyl- 4'-methoxydibenzoylmethane, 2-methyl-5-tert-butyl-4'-methoxy-dibenzoyl methane, 2,4-dimethyl-4'-methoxy dibenzoylmethane and 2,6-dimethyl-4-tert-butyl-4'-methoxy- dibenzoylmethane.

9. A composition as claimed in any one of claims 1 to 8 wherein the water-soluble sunscreen is either chosen from a IIV-B sunscreen selected from one or more of 2- phenylbenzimidazole-5-sulfonic acid, benzophenone-4 and benzylidene camphor sulfonic acid; and / or from a water-soluble IIV-A sunscreen selected from one or more of di sodium phenyl dibenzimidazole tetra sulfonate and terephthalylidene dicamphor sulfonic acid.

10. A composition as claimed in any one of claims 1 to 9 wherein the non-ionic surfactant has an HLB value in the range of 12 to 20.

11. A composition as claimed in any one of claims 1 to 10 wherein the non-ionic surfactant is selected from one or more of a fatty alcohol ethoxylate, fatty acid ethoxylate, alkyl phenol ethoxylate, and polyoxyethylene sorbitan alkyl esters; preferably a fatty alcohol ethoxylate or a fatty acid ethoxylate.

12. A method of protecting the skin from sun-induced damages: a. applying the composition as claimed in any one of claims 1 to 11 on to the skin; and b. optionally, rinsing the skin with water.

13. Use of the composition as claimed in any one of claims 1 to 11 for providing protection from sun-induced damages.

14. Use of a skin care benefit agent selected from acetyl glutamic acid, acetyl glutamine, acetyl methionine, acetyl tyrosine, or a derivative, or a salt, or mixtures thereof, in a personal care composition comprising an oil soluble sunscreen, a water-soluble sunscreen and a nonionic surfactant having HLB value in the range from 9 to 20, wherein the composition further comprises 0.25 to 5 wt% of a polymer selected from one or more of (a) dimethicone / vinyldimethicone crosspolymer and b) hydrophobically modified silica, for protecting skin from sun-induced damages.

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