Composition having whitening efficacy and application thereof in cosmetics

Abstract

Disclosed is a composition having whitening efficacy. The composition comprises artemisinic acid and further comprises nicotinamide and / or glutathione. The compounding of artemisinic acid and nicotinamide and / or glutathione inhibits, by means of different pathways or mechanisms, the generation or transfer of melanin comprehensively and from multiple angles. The composition can significantly inhibit tyrosinase activity and inhibit the production of melanin, and the active ingredients complement each other and achieve synergistic efficacy. In addition, the composition can also enhance the water solubility of artemisinic acid and reduce the local irritation toxicity caused by the insolubility of artemisinic acid, thereby making the artemisinic acid have good water solubility and low local irritation toxicity while achieving the whitening effect, and promoting deep absorption by the skin.

Description

A composition with whitening effect and its application in cosmetics TECHNICAL FIELD

[0001] The present application relates to the cosmetic technology field, in particular to a composition with whitening effect and its application in cosmetics. BACKGROUND

[0002] With the improvement of people's quality of life, more and more attention is paid to the care and maintenance of the skin, and the bright and white skin is a form of beauty. The color of normal human skin is mainly determined by the distribution and condition of various pigments in the skin, the thickness of the skin, and the scattering of light on the surface of the skin. The color spots and color deposition we usually say are related to melanin. The formation process of melanin in the skin includes a series of complex processes such as migration of melanocytes, division and maturation of melanocytes, formation of melanin bodies, transport of melanin granules, and excretion of melanin.

[0003] Pigmentation is a complex and subtle physiological process involving multiple factors and interactions to achieve a more ideal effect. This process is not only affected by internal physiological mechanisms, but also regulated by external environmental factors. From the internal mechanism, pigmentation is closely related to genetics, hormone levels, and metabolic status. Genetic factors play a fundamental role in pigmentation, and the skin color difference among different populations is largely determined by genetics. At the same time, changes in hormone levels can affect the generation and distribution of pigments, such as the skin changes of pregnant women, which is a typical example. In addition, metabolic status also affects the metabolism and excretion of pigments, and thus affects the color of the skin. In terms of external environment, factors such as ultraviolet radiation, chemical stimulation, and inflammation can affect pigmentation. Ultraviolet radiation is one of the main factors leading to skin pigmentation, and long-term exposure to sunlight can cause skin darkening. Chemical substances such as certain drugs and cosmetic ingredients may also cause skin pigmentation. Inflammation can promote the generation and deposition of pigments to some extent.

[0004] Artemisinic acid is a small molecule compound in the sesquiterpenes of Artemisia, which can penetrate the skin. As an intermediate product for the preparation of artemisinin, its biological activity research is currently limited to anti-tumor, and no more extensive research has been carried out.

[0005] SUMMARY

[0006] In view of the deficiencies of the prior art, the purpose of the present application is to provide a composition with whitening effect and its application in cosmetics.

[0007] To achieve this purpose of the present application, the following technical solutions are adopted:

[0008] In a first aspect, the present application provides a composition with whitening effect, which comprises artemisinic acid, and further comprises nicotinamide and / or glutathione.

[0009] Artemisinic acid has strong anti-inflammatory properties, which helps to slow down the aging process of the skin and improve uneven skin tone and dullness. Artemisinic acid reduces the production of melanin by inhibiting key enzymes in the melanin synthesis process, thereby reducing skin pigmentation and achieving whitening effect.

[0010] Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor, which can inhibit the formation of melanocytes and reduce the deposition of melanin. Nicotinamide also inhibits the transfer of melanin to keratinocytes, reduces the deposition of melanin in the stratum corneum, and further prevents skin darkening. Nicotinamide has the effect of promoting skin metabolism, which can accelerate the transfer of melanin in keratinocytes to the stratum corneum and promote the shedding of the stratum corneum. This mechanism helps to improve skin dullness and pigmentation, making the skin look brighter. Nicotinamide also has the effect of anti-glycation, which helps to lighten the yellow color after protein glycation, thereby brightening the skin.

[0011] Glutathione is a natural antioxidant widely found in plants and animals, which can effectively reduce the stimulation of ultraviolet light on melanocytes, prevent the formation of melanin in the body, and fundamentally inhibit or reduce the formation of melanin. It prevents the deposition of melanin and inhibits the appearance of spots and freckles. In addition, glutathione can also regulate peroxide free radicals and enhance blood oxygen sulfhydryl, making the skin more delicate, white and smooth.

[0012] The present application creatively combines artemisinic acid with nicotinamide and / or glutathione, which inhibits the generation or transfer of melanin through different pathways or mechanisms. The composition can significantly inhibit tyrosinase activity and inhibit the production of melanin. The active ingredients complement each other and have synergistic effect. At the same time, the composition can also enhance the water solubility of artemisinic acid, reduce the local irritation toxicity caused by the insolubility of artemisinic acid, achieve the effect of whitening while having good water solubility and low local irritation toxicity, and promote the absorption of the skin.

[0013] Preferably, the composition comprises artemisinic acid and nicotinamide, and the mass ratio of artemisinic acid to nicotinamide is 1:(1-5), wherein (1-5) can be selected from 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, and other specific point values within the range can also be selected, which will not be repeated here.

[0014] Preferably, the composition comprises artemisinic acid and glutathione in a mass ratio of 1 : (5-10), wherein (5-10) can be selected from 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, and other specific point values within the numerical range can be selected, which will not be repeated here one by one.

[0015] Preferably, the composition comprises artemisinic acid, nicotinamide and glutathione in a mass ratio of 1 : (1-5) : (3-7), wherein (1-5) can be selected from 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, and wherein (3-7) can be selected from 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, and other specific point values within the numerical range can be selected, which will not be repeated here one by one.

[0016] The present application also creatively finds that when artemisinic acid, nicotinamide and glutathione are combined in a specific ratio, they can more effectively inhibit the activity of tyrosinase and the generation of melanin, achieving a better whitening effect.

[0017] In a second aspect, the present application provides a skin care product comprising the composition with whitening effect of the first aspect.

[0018] Preferably, the mass percentage content of the composition with whitening effect in the skin care product is 1-20%, for example 1%, 3%, 5%, 7%, 9%, 11%, 13%, 15%, 17%, 20%, and other specific point values within the numerical range can be selected, which will not be repeated here one by one.

[0019] Preferably, the skin care product further comprises any one or a combination of at least two of an antioxidant, a preservative, a humectant, a solubilizer, a chelating agent, an emulsifier, an emollient, a thickening agent, a surfactant, and a pH adjusting agent.

[0020] Preferably, the humectant is selected from any one or a combination of at least two of glycerin, propylene glycol, 1,2-hexanediol, hyaluronic acid, sodium hyaluronate, panthenol, sodium pyrrolidone carboxylate, polyglycerol, butylene glycol, dipropylene glycol, sorbitol, polyethylene glycol, jojoba oil, biosaccharide gum, pentylene glycol, betaine, or trehalose.

[0021] Preferably, the emollient is selected from any one of or a combination of at least two of squalane, borage seed oil, dimethicone, dimethicone crosspolymer, shea butter, jojoba seed oil, macadamia seed oil, grape seed oil, olea europaea fruit oil, cetyl palmitate, ethylhexyl palmitate, tocopheryl acetate, hydrogenated polyisobutene, C10-18 triglycerides, caprylic / capric triglyceride, cyclohexasiloxane, cyclopentasiloxane, dimethiconol, octyl trimethylsiloxysilicate, dicaprylyl carbonate, isododecane, or pentaerythrityl tetraisostearate.

[0022] Preferably, the skin care product comprises a cosmetic water, essence, emulsion, cream, gel, mask, or facial cleanser.

[0023] Compared with the prior art, the present application has the following beneficial effects:

[0024] The present application creatively compounds artemisinic acid with nicotinamide and / or glutathione, and inhibits the generation or transfer of melanin in a comprehensive and multi-angle manner through different pathways or mechanisms. The composition can significantly inhibit tyrosinase activity and inhibit the production of melanin. The active ingredients complement each other and synergize. At the same time, the composition also solves the problem of poor water solubility of artemisinic acid, reduces the toxicity of artemisinic acid, achieves the effect of whitening while having good water solubility and low toxicity, and promotes deep skin absorption. BRIEF DESCRIPTION OF DRAWINGS

[0025] Figure 1 is a water solubility test result graph, wherein 1 is an artemisinic acid aqueous solution, 2 is an artemisinic acid DMSO solution, 3 is a nicotinamide aqueous solution, 4 is a glutathione aqueous solution, 5 is an Example 5 composition aqueous solution, 6 is an Example 7 composition aqueous solution, and 7 is an Example 1 composition aqueous solution. DETAILED DESCRIPTION

[0026] The technical solutions of the present application are further illustrated by specific embodiments. Those skilled in the art should understand that the embodiments are only to help understand the present application and should not be regarded as specific limitations of the present application.

[0027] In the following examples, the reagents and consumables used are purchased from conventional reagent manufacturers in the art, and the experimental methods and technical means used are conventional methods and means in the art, unless otherwise specified.

[0028] The artemisinic acid, nicotinamide, and glutathione referred to below are calculated based on the actual active ingredient content contained in commercially available raw materials, and the commercially available raw materials also selectively contain any one of or a combination of at least two of a solvent, a filler, a diluent, a stabilizer, a pH adjuster, an antibacterial agent, an antioxidant, or an impurity within the permissible range.

[0029] Artemisinic acid involved in the following examples, comparative examples, application examples, comparative application examples are purchased from De Sutai Meitian Biotechnology Co., Ltd. product type is DQ0048;

[0030] Sodium hyaluronate is purchased from Merck Sigma-Aldrich product type is S0780000;

[0031] Carbomer 980 is purchased from Solabia Technology Co., Ltd. product type is YS177293;

[0032] Avocado butter is purchased from Baichuan Biotechnology (Shanxi) Co., Ltd. product type is 24-06-2026;

[0033] Polydimethylsiloxane is purchased from Shanghai Macklin Biochemical Technology Co., Ltd. product type is D849784;

[0034] PEG-60 hydrogenated castor oil is purchased from Shanghai Macklin Biochemical Technology Co., Ltd. product type is E875014;

[0035] Artemisinin extract is prepared by the following method: 15 times (m / v) 95% ethanol is added to Artemisia annua, ultrasonic extraction twice, 1.5h each time, filtration, and the extract is concentrated and freeze-dried to obtain artemisinin extract.

[0036] Example 1

[0037] The present embodiment provides a composition with whitening effect, which includes the following effective ingredients in weight parts: artemisinic acid 1 part, nicotinamide 3 parts, glutathione 5 parts.

[0038] Example 2

[0039] The present embodiment provides a composition with whitening effect, which includes the following effective ingredients in weight parts: artemisinic acid 1 part, nicotinamide 2 parts, glutathione 6 parts.

[0040] Example 3

[0041] The present embodiment provides a composition with whitening effect, which includes the following effective ingredients in weight parts: artemisinic acid 1 part, nicotinamide 4 parts and glutathione 4 parts.

[0042] Example 4

[0043] The present embodiment provides a composition with whitening effect, which includes the following effective ingredients in weight parts: artemisinic acid 1 part, nicotinamide 2 parts.

[0044] Example 5

[0045] The present embodiment provides a composition with whitening effect, which includes the following effective ingredients in weight parts: artemisinic acid 1 part, nicotinamide 3 parts.

[0046] Example 6

[0047] The present example provides a composition having whitening efficacy, comprising the following effective ingredients by weight parts: artemisinic acid 1 part, glutathione 8 parts.

[0048] Example 7

[0049] The present example provides a composition having whitening efficacy, comprising the following effective ingredients by weight parts: artemisinic acid 1 part, glutathione 5 parts.

[0050] Example 8

[0051] The present example provides a composition having whitening efficacy, comprising the following effective ingredients by weight parts: artemisinic acid 1 part, nicotinamide 1 part, glutathione 1 part.

[0052] Example 9

[0053] The present example provides a composition having whitening efficacy, comprising the following effective ingredients by weight parts: artemisinic acid 3 parts, nicotinamide 1 part, glutathione 10 parts.

[0054] Example 10

[0055] The present example provides a composition having whitening efficacy, comprising the following effective ingredients by weight parts: artemisinic acid 3 parts, nicotinamide 1 part.

[0056] Example 11

[0057] The present example provides a composition having whitening efficacy, comprising the following effective ingredients by weight parts: artemisinic acid 1 part, glutathione 1 part.

[0058] Comparative Example 1

[0059] The present comparative example provides a composition having whitening efficacy, comprising the following effective ingredients by weight parts: nicotinamide 3 parts, glutathione 5 parts.

[0060] Comparative Example 2

[0061] The present comparative example provides a composition having whitening efficacy, which is only different from Example 1 in that artemisinic acid is replaced by artemisinin in equal mass.

[0062] Comparative Example 3

[0063] The present comparative example provides a composition having whitening efficacy, which is only different from Example 1 in that artemisinic acid is replaced by artemisinin extract in equal mass.

[0064] Comparative Example 4

[0065] The comparative example provides a substance with whitening effect, which comprises a single effective component artemisinic acid.

[0066] Comparative example 5

[0067] The comparative example provides a substance with whitening effect, which comprises a single effective component nicotinamide.

[0068] Comparative example 6

[0069] The comparative example provides a substance with whitening effect, which comprises a single effective component glutathione.

[0070] Application example 1

[0071] The application example provides a cream with whitening effect, which has the following formula:

[0072] The preparation method is as follows:

[0073] (1) sequentially add A raw materials into an emulsifying pot, heat to 80℃, and homogenously stir and dissolve uniformly;

[0074] (2) heat B raw materials to 80℃ to dissolve, and stir and disperse uniformly;

[0075] (3) add C into a stirring pot, stir uniformly, and homogenously stir and dissolve uniformly;

[0076] (4) after heating D raw materials to 60℃ to dissolve and become transparent, add like flowers to disperse uniformly, and cool to 40℃;

[0077] (5) after dispersing E raw materials uniformly, add into a stirring pot to disperse uniformly, cool to 20℃, and the whitening cream is obtained.

[0078] Application example 2

[0079] The application example provides a lotion with whitening effect, which has the following formula:

[0080] The preparation method is as follows:

[0081] (1) sequentially add A raw materials into a stirring pot, heat to 60℃, and homogenously stir and dissolve uniformly;

[0082] (2) after heating B raw materials to 60℃ to dissolve and become transparent, add into a stirring pot to disperse uniformly, and cool to 40℃;

[0083] (3) add C into a stirring pot, stir uniformly;

[0084] (4) add D raw materials and stir uniformly, and cool to below 37℃, and the whitening lotion is obtained.

[0085] Application example 3

[0086] The application example provides a lotion with whitening effect, and the formula is as follows:

[0087] The preparation method is as follows:

[0088] (1) sequentially add A raw materials into an emulsifying kettle, heat to 80 DEG C, and homogenously stir and dissolve;

[0089] (2) heat B raw materials to 80 DEG C, dissolve and disperse uniformly, and cool to 60 DEG C;

[0090] (3) add C into the emulsifying kettle and stir uniformly;

[0091] (4) add D raw materials and stir uniformly, and cool to below 37 DEG C, so that the whitening lotion is obtained.

[0092] Test Example 1

[0093] The compositions prepared in Examples 1-11 and Comparative Examples 1-6 are subjected to tyrosinase inhibition effect determination in the test example:

[0094] L-tyrosine is used as a substrate, and is divided into an experimental group, a blank group and a positive control group.

[0095] The experimental group: 100 μL (0.5 mg / mL) of L-tyrosine, 50 μL (200 U / mL) of tyrosinase and 50 μL (5 mg / mL) of the aqueous solution of the composition prepared in Examples 1-11 and Comparative Examples 1-6 are sequentially added into a 96-well plate;

[0096] The blank group: 100 μL (0.5 mg / mL) of L-tyrosine, 50 μL (200 U / mL) of tyrosinase and 50 μL of PBS buffer are sequentially added into a 96-well plate;

[0097] The positive control group: 100 μL (0.5 mg / mL) of L-tyrosine, 50 μL (200 U / mL) of tyrosinase and 50 μL (5 mg / mL) of the aqueous solution of alpha-arbutin are sequentially added into a 96-well plate.

[0098] After 30 min of light-free reaction, the absorbance value is determined at 475 nm by placing into an enzyme marker, and the tyrosinase inhibition rate is calculated, and the results are shown in Table 1.

[0099] Table 1

[0100] As shown by the data in Table 1, the tyrosinase inhibition rates of the compositions prepared in Examples 1-11 are all above 80%, which indicates that the compositions involved in the application can well inhibit the activity of tyrosinase.

[0101] Comparing Example 1, Example 5, Example 7 with Comparative Example 1, it can be found that the combination of artemisinic acid, nicotinamide and glutathione has a synergistic effect on inhibiting the activity of tyrosinase.

[0102] Comparing Example 1 with Example 8-9, Example 4-5 with Example 10, Example 6-7 with Example 11, respectively, it can be found that when the artemisinic acid, nicotinamide and glutathione in the composition are selected in a specific ratio, the tyrosinase inhibition rate can be further improved.

[0103] Comparing Example 1 with Comparative Example 2-3, it can be found that compared with artemisinin and artemisinin extract, artemisinic acid can achieve better inhibition of the activity of tyrosinase.

[0104] Test Example 2

[0105] In this test example, the cytotoxicity of the compositions prepared in Example 1-3, 5-6 and Comparative Example 4 was determined.

[0106] B16F10 cells in good growth state were taken, and after digestion, a cell suspension was prepared by adding 10% FBS DMEM medium. The cells were inoculated into a 96-well plate at a concentration of 5x10 4 6 and Comparative Example 4 was added to the cell culture medium. At the same time, a control group (the composition solution was replaced with complete culture medium) and a blank group (only complete culture medium) were set up, and each group had three replicate wells. After 24h of incubation at 37℃ and 5% CO2, 25μL MTT was added for 2-4h of incubation. After the culture medium was washed away, 150μL DMSO was added per well, and the mixture was shaken for 10min. The absorbance value was determined at a wavelength of 570nm using an enzyme-labeled instrument, and the cell survival rate was calculated. The results are shown in Table 2.

[0107] Table 2

[0108] As can be seen from the data in Table 2, the cell survival rates of the compositions prepared in Example 1-3, 5-6 are all above 100%, indicating that they have very low toxicity and can even promote cell growth. Comparing them with Comparative Example 4, it can be fully illustrated that the composition involved in the present application can effectively reduce the toxicity of artemisinic acid and has a detoxification and proliferation effect on cells.

[0109] Comparing Example 1-3 with Example 5-6, it can be found that the combination of artemisinic acid, nicotinamide and glutathione can more effectively reduce the toxicity of artemisinic acid compared with the combination of artemisinic acid and nicotinamide, and artemisinic acid and glutathione.

[0110] Test Example 3

[0111] The compositions prepared in Examples 1-11 and Comparative Examples 1-6 were subjected to biological activity evaluation (cell experiment) in this test example:

[0112] B16F10 cells in exponential growth phase were trypsinized and inoculated in 96-well plates at a cell density of 7x10 4 After overnight adhesion, the medium was replaced and the compositions prepared in Examples 1-11 and Comparative Examples 6 were treated for 48 h at a concentration of 200 μM in complete medium. Each sample was prepared in triplicate. The cultured cells were discarded and washed once with PBS. The cell culture dish was placed on an ice plate and 330 μL of non-denaturing cell lysis solution (containing 1 mM PMSF) was added to each dish. The cells were lysed at 4°C for 20 min. The cells were collected by centrifugation at 13,000 r / min for 10 min. The melanin precipitate was at the bottom of the centrifuge tube. 330 μL of NaOH (containing 10% DMSO) was added and vortexed to facilitate complete lysis. The mixture was placed in a metal bath at 80°C for 2 h to completely dissolve the melanin precipitate. The mixture was vortexed and 200 μL of melanin lysis solution was added to each well of a 96-well plate.

[0113] A blank group (ultrapure water) and a control group (the composition solution was replaced with complete medium) were also set up. The OD value was measured at 405 nm. The results are shown in Table 3.

[0114] Table 3

[0115] As can be seen from the data in Table 3, the composition according to the present application can effectively inhibit melanin production.

[0116] Comparing Example 1, Example 5, Example 7 and Comparative Example 1, it can be found that the combination of artemisinic acid, nicotinamide and glutathione has a synergistic effect on inhibiting melanin production.

[0117] Comparing Example 1 with Examples 8-9, Examples 4-5 with Example 10, and Examples 6-7 with Example 11, it can be found that when artemisinic acid, nicotinamide and glutathione are selected at a specific ratio, the melanin production can be further inhibited.

[0118] Comparing Example 1 with Comparative Examples 2-3, it can be found that compared with artemisinin and artemisinin extract, artemisinic acid can achieve better inhibitory effect on melanin production.

[0119] Test Example 4

[0120] The test example is carried out on the water-solubility of Example 1, 5, 7 and Comparative Examples 4, 5, 6:

[0121] 10 mg of artemisinic acid, nicotinamide and glutathione are respectively dissolved in 5 mL of solvent to observe whether they can be dissolved or have granular precipitates, and the results are shown in Figure 1 (1 is artemisinic acid aqueous solution, 2 is artemisinic acid DMSO solution, 3 is nicotinamide aqueous solution, 4 is glutathione aqueous solution, 5-7 are respectively aqueous solutions of the compositions of Examples 5, 7, 1). A large amount of artemisinic acid precipitates in water, while when nicotinamide or glutathione is added or all three are added at the same time, there is no granular precipitate in the solution and the solution is clear, indicating that the water-solubility of the composition is good. The present application solves the problem of poor water-solubility of artemisinic acid by compounding artemisinic acid with nicotinamide and / or glutathione.

[0122] Test Example 5

[0123] The human body whitening experiment is carried out on the cream prepared in Application Example 1:

[0124] In order to exclude other interference and verify the whitening effect of the composition, the applicant selects 8 volunteers with healthy skin and no history of skin care product allergy, takes the arm area as the test site, selects an appropriate size area, half of which is applied with the cream with whitening effect prepared in Application Example 1, and the other half is applied with the blank control cream (a blank control cream prepared without adding the composition of Example 1, the rest of the ingredients and the preparation method remain the same as Application Example 1). Each is used once a day in the morning and evening, and is continuously used for 4 weeks, and is avoided from being washed away after application. The content of melanin in the skin is checked with a skin melanin tester before use and every week. The results are shown in Table 4.

[0125] Table 4

[0126] As can be seen from the data in Table 4, the cream of Application Example 1 has better ability to reduce pigment deposition, and the melanin content of the skin of the arm of the subjects is generally reduced by about 20 after four weeks of use, while the melanin content of the blank control cream under the same conditions fluctuates around the initial value, and the change is not obvious. It is shown that the composition prepared in Example 1 has obvious effect of reducing pigment deposition.

[0127] The applicant declares that the technical solutions of the present application are illustrated by the above examples, but the present application is not limited to the above examples, i.e. it does not mean that the present application must rely on the above examples to be implemented. It should be understood by those skilled in the art that any improvement of the present application, equivalent replacement of each raw material of the product of the present application and addition of auxiliary ingredients, selection of specific methods, etc. fall within the protection scope and disclosure scope of the present application.

[0128] The preferred embodiments of the present application are described in detail above, but the present application is not limited to the specific details of the above-described embodiments, and various simple modifications can be made to the technical solutions of the present application within the technical concept of the present application, and these simple modifications all belong to the protection scope of the present application.

[0129] In addition, it should be noted that each specific technical feature described in the above specific embodiments can be combined in any appropriate manner without contradiction, and in order to avoid unnecessary repetition, the present application will not describe various possible combinations again.

Claims

1. A composition having whitening efficacy, characterized by, The composition comprises artemisinic acid, and further comprises nicotinamide and / or glutathione.

2. The composition with whitening effect according to claim 1, characterized in that, The composition comprises artemisinic acid and nicotinamide, and the mass ratio of the artemisinic acid and the nicotinamide is 1:(1-5).

3. The composition with whitening effect according to claim 1, characterized in that, The composition comprises artemisinic acid and glutathione, and the mass ratio of the artemisinic acid and the glutathione is 1:(5-10).

4. The composition with whitening effect according to claim 1, characterized in that, The composition comprises artemisinic acid, nicotinamide and glutathione, and the mass ratio of the artemisinic acid, the nicotinamide and the glutathione is 1:(1-5):(3-7).

5. A skin care product, characterized by, The skin care product comprises the composition with whitening efficacy according to any one of claims 1-4.

6. The skin care product according to claim 5, characterized in that The mass percentage content of the composition with whitening efficacy in the skin care product is 1-20%.

7. The skin care product according to claim 5 or 6, characterized in that The skin care product further comprises any one or a combination of at least two of an antioxidant, a preservative, a humectant, a solubilizer, a chelating agent, an emulsifier, an emollient, a thickening agent, a surfactant, a pH adjusting agent.

8. The skin care product according to claim 7, characterized in that The humectant is selected from any one or a combination of at least two of glycerin, propylene glycol, 1,2-hexanediol, hyaluronic acid, sodium hyaluronate, panthenol, sodium pyrrolidone carboxylate, polyglycerin, butylene glycol, dipropylene glycol, sorbitol, polyethylene glycol, jojoba oil, biosaccharide gum, pentylene glycol, betaine or trehalose.

9. The skin care product according to claim 7 or 8, characterized in that The emollient is selected from any one or a combination of at least two of squalane, argan seed oil, dimethicone, dimethicone crosspolymer, shea butter, jojoba seed oil, macadamia seed oil, grape seed oil, oil olive fruit oil, cetyl palmitate, ethylhexyl palmitate, tocopheryl acetate, hydrogenated polyisobutene, C10-18 fatty acid triglycerides, caprylic / capric triglyceride, cyclohexasiloxane, cyclopentasiloxane, dimethiconol, octyl trimethylsiloxysilicate, dicaprylyl carbonate, isododecane or pentaerythrityl tetraisostearate.

10. Skin care product according to any of claims 5 to 9, characterized in that The skin care product comprises a cosmetic water, an essence, a lotion, a cream, a gel, a pack or a cleanser.

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