Contact imaging apparatus

Abstract

Provided in the present disclosure is a contact imaging apparatus. The contact imaging apparatus comprises a controller, an imaging main unit, a cover body and an adjustable light source module, wherein the adjustable light source module is arranged on the inner side of the cover body, and the adjustable light source module and an imaging module of the imaging main unit are both in communication connection with the controller; when the cover body covers the imaging main unit to form a dark chamber state, the controller is used for sending different driving instructions to the adjustable light source module at different collection moments, so as to drive the adjustable light source module to emit light signals of matching colors, respectively; and the imaging module is used for separately collecting an intermediate image of a biological sample membrane under a light signal at each of the collection moments, so as to output color images corresponding to the biological sample membrane. The apparatus of the present disclosure can automatically and efficiently implement the color imaging of a biological sample membrane, so as to facilitate more comprehensive and accurate analysis of the biological sample membrane, thereby satisfying imaging scenarios having higher requirements.

Description

Contact imaging device

[0001] The present disclosure claims priority to Chinese patent application 2024224012601 with a filing date of September 29, 2024, and priority to Chinese patent application 202422665900X with a filing date of November 1, 2024. The present disclosure incorporates the entirety of the aforementioned Chinese patent applications. TECHNICAL FIELD

[0002] The present disclosure relates to the technical field of bio-imaging, in particular to a contact imaging device. BACKGROUND

[0003] At present, for the imaging of biological sample films, the technology of black and white imaging is generally used to obtain corresponding images; however, the imaging results of black and white images often cannot meet the imaging analysis scenes with higher demands.

[0004] Western blot (WB) technology, also known as protein blotting technology, is one of the most commonly used technologies in biomedical research. Protein bands are distributed on the Western blot sample film, and these bands are usually visualized by chemiluminescence. Existing devices for image acquisition of biological samples can only preset parameters for imaging components before leaving the factory, and cannot easily change parameters, and also cannot select appropriate operation modes according to the operation habits or operation environment of operators, which is relatively inconvenient to use. SUMMARY

[0005] The technical problem to be solved by the present disclosure is to overcome the above-mentioned defects in the prior art, and the purpose is to provide a contact imaging device.

[0006] The present disclosure solves the above technical problems by the following technical solutions:

[0007] The present disclosure provides a contact imaging device, which comprises a controller, an imaging main body, a cover body and an adjustable light source module;

[0008] The imaging main body comprises a main body structure and an imaging module arranged on the main body structure, and the imaging module is used for placing a biological sample film; the adjustable light source module is arranged on the inner side of the cover body, and the adjustable light source module and the imaging module are in communication connection with the controller;

[0009] When the cover body is arranged on the imaging main body to form a darkroom state, the controller is used to send different driving instructions to the adjustable light source module at different acquisition moments to drive the adjustable light source module to emit light signals of matching colors, respectively;

[0010] The imaging module is configured to acquire intermediate images of the biological sample film under the light signal at each of the acquisition time points, and output a corresponding color image of the biological sample film.

[0011] Preferably, the adjustable light source module is in communication with the controller through a plurality of communication cables.

[0012] The different communication cables are driven by different driving instructions to drive the adjustable light source module to emit light signals of different colors.

[0013] Preferably, the adjustable light source module includes a light-emitting auxiliary component and a light-emitting component.

[0014] The light-emitting component is a backlight source capable of emitting light of different colors.

[0015] The light-emitting component is arranged in a recess structure on the inner side of the cover body, and the light-emitting auxiliary component is arranged on the cover body and covers the light-emitting component in the recess structure.

[0016] Preferably and / or, the light-emitting component includes a plurality of lamp beads and / or a light-emitting screen.

[0017] Preferably, the arrangement position of the light-emitting component is matched and set based on a preset placement position of the biological sample film.

[0018] Preferably, when the light-emitting component includes a plurality of lamp beads, the plurality of lamp beads are uniformly distributed in a structure region of the recess structure, and the structure region is arranged corresponding to the imaging of the imaging module.

[0019] Preferably, the light collection sequences corresponding to different biological sample films are different, and different light collection sequences correspond to different light color combinations.

[0020] And / or,

[0021] The imaging module is configured to detect a signal projected by the light signal emitted by the adjustable light source module after being irradiated to the biological sample film, to obtain the intermediate image corresponding to the acquisition time point.

[0022] Preferably, the controller is arranged in the main body structure, and the imaging main body further includes a touch display screen arranged on the main body structure and in communication with the controller.

[0023] And / or,

[0024] The imaging main body further includes an external port, and the external port includes an interface connected with a mouse and / or a keyboard.

[0025] Preferably, the imaging body further comprises a memory arranged in the body structure, the memory being configured to store the intermediate image and / or the color image.

[0026] The body structure is further provided with a data transmission port, the data transmission port being configured to transmit the intermediate image and / or the color image to an external device.

[0027] And / or,

[0028] The imaging body further comprises a power module arranged in the body structure, the power module being configured to supply power to the contact imaging device.

[0029] Preferably, the imaging body further comprises a cooling mechanism arranged in the body structure and in signal connection with the controller, the cooling mechanism being configured to reduce the internal temperature of the imaging device.

[0030] And / or,

[0031] The imaging body further comprises a wireless communication module arranged in the body structure and in signal connection with the controller, the wireless communication module being configured to wirelessly communicate with an external communication device.

[0032] And / or,

[0033] The body structure is further provided with a power supply interface, the power supply interface being configured to be electrically connected with an external power supply to supply power to the power module.

[0034] And / or,

[0035] The power module comprises a wireless power supply module, the wireless power supply module being configured to be wirelessly connected with an external power supply to wirelessly supply power to the power module.

[0036] Preferably, the contact imaging device comprises a housing, the housing comprising a first cavity, the first cavity being a dark space and being configured to be opened or closed, a CMOS detector assembly being arranged in the first cavity, the CMOS detector assembly being configured to convert light signals generated by a detected sample into an image, the housing further comprising a second cavity arranged below the first cavity, a control mainboard being arranged in the second cavity, the control mainboard being in signal connection with the CMOS detector assembly, the housing being further provided with an external port, the external port being in electrical connection with the control mainboard, the external port being configured to enable the contact imaging device to be operatively connected with an external device.

[0037] In the scheme, the biological sample film is collected by the CMOS detector in contact mode, the light signal loss is small, and the obtained image is relatively clear; the control mainboard is arranged to make the contact imaging device operably connected with external equipment, the contact imaging device can be debugged in real time according to the displayed image, and each parameter can be adjusted.

[0038] Preferably, the external port includes an interface connected with a mouse and a keyboard.

[0039] In the scheme, the mouse and keyboard connection port is arranged, so that the staff can debug the contact imaging device, conduct data transmission or adjust the imaging parameters of the contact imaging device through the mouse and keyboard.

[0040] Preferably, the contact imaging device further comprises a touch display screen, and the touch display screen is connected with the control mainboard.

[0041] In the scheme, the control mainboard is controlled through the touch display screen, and the imaging result can be displayed according to the requirement, so that the imaging parameters are adjusted to obtain the best imaging effect.

[0042] Preferably, the touch display screen and the external port are arranged on the opposite sides of the shell.

[0043] By adopting the above structure design, when the external equipment is connected, the external wire does not interfere with the touch display screen.

[0044] Preferably, a cover is hingedly connected to the shell, and the first chamber opens or closes the darkroom space through the cover.

[0045] An inner top surface of the cover is provided with a backlight assembly, and the backlight assembly is used to provide an imaging light source for the CMOS detector assembly.

[0046] By adopting the above structure design, the opening and closing of the darkroom space can be realized, the biological sample film to be imaged can be conveniently placed in the darkroom space, and the CMOS detector can conveniently collect the signal of the biological sample film through the light source on the backlight assembly to obtain an imaging image.

[0047] Preferably, the control mainboard is connected with a power supply on the backlight assembly and is used to control the brightness of the light source.

[0048] In the scheme, the brightness of the light source can be controlled to obtain the best imaging image, so as to facilitate subsequent analysis.

[0049] Preferably, a cooling mechanism is further arranged in the second chamber, and the cooling mechanism is used to reduce the internal temperature of the contact imaging device.

[0050] In the scheme, the cooling mechanism is arranged to cool the inside of the contact type imaging device, so as to avoid the inside of the contact type imaging device from overheating and affecting the stability of imaging, thereby obtaining a better imaging image.

[0051] Preferably, the bottom plate of the second chamber is located above the plane where the support part of the contact type imaging device is located, and the bottom plate of the second chamber is provided with a ventilation hole.

[0052] In the scheme, the bottom of the contact type imaging device is in communication with the outside air, so as to facilitate heat dissipation, thereby avoiding the inside of the contact type imaging device from overheating and affecting the stability of imaging.

[0053] Preferably, the CMOS detector assembly comprises a CMOS detector body, and a fiber panel and / or a protective film are arranged above the photosensitive area of the CMOS detector body.

[0054] In the scheme, the fiber panel or the protective film is arranged to protect the CMOS detector body without affecting the imaging effect.

[0055] On the basis of common sense in the art, the preferred conditions can be combined arbitrarily, thereby obtaining the preferred embodiments of the present disclosure.

[0056] The positive progress effect of the present disclosure is that:

[0057] In the present disclosure, a new contact type imaging device is proposed, which can adjust the light source module to emit different color light signals in turn through multiple driving, so as to obtain the images of the biological sample film under each monochromatic light signal respectively, and through the calibration and fusion processing of these images, the final corresponding color imaging of the biological sample film is obtained, so as to realize the automatic and efficient completion of the color imaging of the biological sample film, so as to more accurately, clearly and comprehensively reflect the characteristics and state of the biological sample film through color imaging, so as to facilitate more accurate analysis of the biological sample film, and solve the problem that the existing Mark imaging can only be black and white, which cannot meet the requirements of actual imaging scenes, and meet the imaging scenes with higher requirements.

[0058] In addition, the contact type imaging device in the present disclosure adopts the CMOS detector to contact type collect the biological sample film, so that the light signal loss is small, and the obtained image is relatively clear; the control mainboard is arranged to make the contact type imaging device operably connected with the external equipment, so that the contact type imaging device can be debugged in real time according to the displayed image, and each parameter can be adjusted. BRIEF DESCRIPTION OF DRAWINGS

[0059] Fig. 1 is a module schematic diagram of the contact type imaging device of the embodiment 1 of the present disclosure.

[0060] Fig. 2 is a schematic diagram of the contact imaging device of the present disclosure in an open state.

[0061] Fig. 3 is a schematic diagram of the contact imaging device of the present disclosure in a closed state.

[0062] Fig. 4 is a schematic diagram of a conventional black-and-white imaging.

[0063] Fig. 5 is a schematic diagram of color imaging output by the contact imaging device of the present disclosure.

[0064] Fig. 6 is a schematic diagram of the contact imaging device of the present disclosure.

[0065] Fig. 7 is a schematic diagram of the adjustable light source module of the contact imaging device of the present disclosure.

[0066] Fig. 8 is a schematic diagram of the overall structure of the contact imaging device of the present disclosure.

[0067] Fig. 9 is a schematic diagram of the first structure of the contact imaging device of the present disclosure with a display screen.

[0068] Fig. 10 is a schematic diagram of the second structure of the contact imaging device of the present disclosure with a display screen.

[0069] Fig. 11 is a schematic diagram of the external structure of the contact imaging device of the present disclosure.

[0070] Fig. 12 is a schematic diagram of the external structure of the contact imaging device of the present disclosure from another angle.

[0071] Fig. 13 is a front view of the contact imaging device of the present disclosure.

[0072] Fig. 14 is a sectional view of the contact imaging device of the present disclosure in the A-A direction.

[0073] Fig. 15 is an enlarged schematic diagram of the partial structure at B in Fig. 14.

[0074] Fig. 16 is a schematic diagram of the bottom structure of the contact imaging device of the present disclosure.

[0075] Legend of reference numerals: housing 100, housing body 101, device middle frame 102, control mainboard mounting rack 103, shielding cover 104, bottom plate 105, support part 106, air outlet 107, first chamber 110, second chamber 120, upper cover 200, back plate assembly 210, touch display screen 300, external port 400, CMOS detector assembly 500, CMOS detector body 501, optical fiber panel 502, control mainboard 600, interface board 700, sealing member 800, elastic sealing ring 900. DETAILED DESCRIPTION

[0076] The present disclosure will be further illustrated by the following examples, but the present disclosure is not limited to the examples. For the purpose of making the technical solutions, purposes, and advantages of the embodiments of the present disclosure clearer, the technical solutions in the embodiments of the present disclosure will be described clearly and completely below with reference to the drawings in the embodiments of the present disclosure. Obviously, the described embodiments are part of the embodiments of the present disclosure, rather than all the embodiments.

[0077] Embodiment 1

[0078] As shown in FIG. 1, the contact imaging device of the present embodiment comprises a controller 1, an imaging body 2, a cover 3, and an adjustable light source module 4. The adjustable light source module 4 can emit light of different colors, including red, green, blue, yellow, white, etc.

[0079] The imaging body 2 comprises a body structure 5 and an imaging module 6 arranged on the body structure 5, and the imaging module 6 is used for placing a biological sample film. The adjustable light source module 4 is arranged inside the cover 3, and the adjustable light source module 4 and the imaging module 6 are both in communication connection with the controller 1.

[0080] The cover 3 is connected with the imaging body 2 by means of hinging or the like, or can be integrally formed with the imaging body 2. As shown in FIG. 2, when placing the biological sample film, the cover 3 is opened to place the biological sample film. As shown in FIG. 3, when the biological sample film is placed and imaging is ready to be performed, the cover 3 is arranged on the imaging body 2 to form a darkroom environment, so as to avoid interference and ensure the imaging quality. Specifically, the cover 3 can be manually opened or closed, or a power mechanism can be integrated in the cover 3 and / or the imaging body 2, and the power mechanism is in communication connection with the controller 1 to automatically drive the cover 3 to perform the opening or closing operation, thereby improving the intelligent degree of the whole imaging process, and improving the convenience and flexibility of the operation.

[0081] When the cover 3 is arranged on the imaging body 2 to form a darkroom state, the controller 1 is used for sending different driving instructions to the adjustable light source module 4 at different collection moments, so as to drive the adjustable light source module 4 to respectively emit light signals of matching colors.

[0082] The imaging module 6 is used for respectively collecting intermediate images of the biological sample film under the light signals at each collection moment, so as to output the corresponding color images of the biological sample film.

[0083] For example, at the first acquisition time, a drive command to emit blue light is sent to the adjustable light source module 4, and the adjustable light source module 4 responds to the corresponding drive command and emits the corresponding blue light; at the second acquisition time, a drive command to emit red light is sent to the adjustable light source module 4, and the adjustable light source module 4 responds to the corresponding drive command and emits the corresponding red light; similarly, at the third acquisition time, a drive command to emit yellow light is sent to the adjustable light source module 4, and the adjustable light source module 4 responds to the corresponding drive command and emits the corresponding yellow light; at the fourth acquisition time, a drive command to emit green light is sent to the adjustable light source module 4, and the adjustable light source module 4 responds to the corresponding drive command and emits the corresponding green light... and so on, so it will not be described in detail here.

[0084] Imaging module 6 is used to acquire images of the biological sample membrane under different light signals at these acquisition times, calibrate several of these images, and then fuse the calibrated images to obtain the final color image of the biological sample membrane.

[0085] In particular, the images of biological sample membranes at different acquisition times will be stored in a timely manner for subsequent summarization and processing.

[0086] Specifically, as shown in Figure 4, the images acquired by the existing bonding imaging technology are all black and white. However, such imaging results cannot meet the higher requirements of imaging analysis. This disclosure solves the problem that existing Mark imaging can only produce black and white images, failing to meet the requirements of actual imaging scenarios. As shown in Figure 5, it achieves color imaging of biological sample membranes. For example, in Figure 5, the dashed area A corresponds to the blue imaging result, and the dashed area B corresponds to the red imaging result. This more accurately, clearly, and comprehensively reflects the characteristics and state of the biological sample membrane, facilitating better analysis and meeting higher requirements of imaging analysis. It should be noted that Figure 5 is an exemplary illustration of a color imaging result. Figure 5 only includes different color blocks similar to those in Figure 4. The difference between Figure 5 and Figure 4 is that the color blocks in Figure 5 are colored. Also, there are no dashed boxes in Figure 5; the dashed lines are only used to distinguish the different colors in the color imaging results for ease of understanding.

[0087] The contact imaging device of this embodiment can be applied in many fields, including but not limited to protein detection, nucleic acid detection, isotope detection, cell detection, tissue detection and other detection scenarios.

[0088] In the scheme, a new contact imaging device is proposed, which can automatically and efficiently complete the color imaging of the biological sample film by adjusting the adjustable light source module 4 to emit light signals of different colors in turn to obtain the images of the biological sample film under each monochromatic light signal, and then calibrating and fusing the images to obtain the final corresponding color imaging of the biological sample film, so as to more accurately, clearly and comprehensively reflect the characteristics and state of the biological sample film through color imaging, so as to more accurately analyze the biological sample film, solve the problem that the existing Mark imaging can only be black and white, and cannot meet the requirements of actual imaging scenes, and meet the imaging scenes with higher requirements.

[0089] Embodiment 2

[0090] The contact imaging device of the embodiment is a further improvement of the embodiment 1, in particular:

[0091] In an implementable scheme, as shown in FIGS. 6 and 8, the adjustable light source module 4 is in communication connection with the controller 1 through a plurality of communication cables 7;

[0092] Among them, different communication cables 7 pass through different driving instructions to drive the adjustable light source module 4 to emit light signals of different colors. The controller 1 is integrally arranged in the imaging main body 2 or the cover 3, preferably, in the imaging main body 2. When the controller 1 is arranged in the imaging main body 2, the two ends of the different communication cables 7 are respectively connected to the adjustable light source module 4 and the controller 1, and are hidden between the imaging main body 2 and the cover 3.

[0093] In the scheme, based on different communication cables 7, multiple channels are formed to complete the transmission of different instructions to complete the independent control of light signals of different colors, support the multi-channel imaging technology, and ensure the feasibility, flexibility and accuracy of the color imaging of the contact imaging device.

[0094] In an implementable scheme, as shown in FIGS. 6 and 7, the adjustable light source module 4 includes a light-emitting auxiliary component 8 and a light-emitting component 9;

[0095] Among them, the light-emitting component 9 is a backlight source that can emit light of different colors;

[0096] The light-emitting component 9 is arranged in the recess structure on the inner side of the cover 3 according to a preset distribution mode, and the light-emitting auxiliary component 8 is arranged on the cover 3 and covers the light-emitting component 9 in the recess structure.

[0097] Specifically, the preset distribution mode can be any mode according to actual layout requirements, as long as it can meet the imaging requirements.

[0098] In the scheme, the light-emitting auxiliary component 8 is a light guide plate, a light uniformizing plate, etc., and is used to uniformly process the light signal after the backlight emits the light signal, so as to ensure the imaging quality under each monochromatic light signal, and further improve the quality of the final color imaging.

[0099] In addition, the light-emitting component 9 is arranged in the recess structure on the inner side of the cover body 3. Such a structure design rationally utilizes the space and avoids unnecessary waste of space structure, thereby ensuring the rationality of the space size of the entire device.

[0100] In an implementable scheme, the light-emitting component 9 includes a plurality of lamp beads, a light-emitting screen, etc. The lamp beads can be LED lamp beads, and the light-emitting screen can be an OLED (a current type organic light-emitting device) light-emitting screen.

[0101] In the scheme, the light-emitting component 9 can be any type of light-emitting device as long as it can meet the corresponding light-emitting requirement.

[0102] In an implementable scheme, the arrangement position of the light-emitting component 9 is matched and set based on the preset placement position of the biological sample film.

[0103] In the scheme, the arrangement of the lamp beads and the arrangement of the OLED light-emitting screen can be matched and set according to the preset placement position of the biological sample film. For example, if the preset placement position is at a central position, the lamp beads can be arranged around the central position, and a small number of lamp beads or even no lamp bead can be arranged at other positions, so that the imaging quality is ensured and unnecessary cost investment is reduced.

[0104] In an implementable scheme, when the light-emitting component 9 includes a plurality of lamp beads, the plurality of lamp beads are uniformly distributed in a structure region of the recess structure, and the structure region is arranged corresponding to the imaging of the imaging module 6.

[0105] In the scheme, all the lamp beads are uniformly distributed in the recess structure on the inner side of the cover body 3, so that the imaging effect can meet the requirement regardless of the placement position of the biological sample film in the imaging region.

[0106] In an implementable scheme, different biological sample films correspond to different light collection sequences, and different light collection sequences correspond to different light color combinations.

[0107] In the scheme, when different biological sample films are imaged, the light collection sequence (i.e., the driving sequence of different color lights) matched with the type of the biological sample film can be used to sequentially irradiate the biological sample film, so as to further ensure the imaging quality of each type of biological sample film.

[0108] Wherein, the light signal sequence corresponding to each type of biological sample film can be determined in advance according to experiments, and of course can be re-adjusted according to actual needs.

[0109] In an implementable scheme, the imaging module 6 is used to detect the signal projected after the light signal emitted by the adjustable light source module 4 irradiates the biological sample film, so as to obtain the intermediate image corresponding to the acquisition time.

[0110] In this scheme, the imaging module 6 includes a CMOS (complementary metal oxide semiconductor) detector, a CCD (charge coupled device) detector, etc., so as to realize imaging processing of the biological sample film attached to the imaging module 6, so as to obtain the image under the corresponding monochromatic light, and ensure the reliability of the imaging processing of the biological sample film.

[0111] In addition, the camera or detector used in the existing conventional imaging method is all of reflection type imaging principle, while the detector in this embodiment is all of projection type, that is, different colors of light are sequentially hit on the sample and directly projected on the detector by projection to obtain the image of the biological sample film under each monochromatic light, and then the images under these monochromatic lights are calibrated and fused to form a color image.

[0112] In an implementable scheme, as shown in FIG. 6, the controller 1 is arranged in the main body structure 5, and the imaging main body 2 further includes a touch display screen 10 arranged on the main body structure 5 and in communication connection with the controller 1.

[0113] In this scheme, as shown in FIG. 2, the contact type imaging device can not be provided with the touch display screen 10; as shown in FIG. 9, the contact type imaging device can also be integrated with the touch display screen 10, so as to facilitate the interaction between the operator and the device, so as to meet the use demand of higher demand, and further improve the intelligent degree of the whole device.

[0114] In an implementable scheme, as shown in FIGS. 6 and 10, the imaging main body 2 is further provided with an external port 11, and the external port 11 includes an interface connected with a mouse and / or a keyboard. Other types of interfaces such as a network cable socket can also be provided.

[0115] In this scheme, by arranging the mouse and keyboard connection port, the staff can conveniently debug the contact type imaging device, conduct data transmission or adjust the imaging parameters of the contact type imaging device through the mouse and keyboard;

[0116] In addition, the contact type imaging device is provided with the touch display screen 10, the external interface of the mouse and the keyboard, etc., so that the user has an additional operable way to choose when operating, and can choose a suitable operation mode according to the operation environment or operation habit, and improves the user's use experience.

[0117] In an implementable solution, the imaging body 2 further comprises a memory 12 arranged in the body structure 5, and the memory 12 is configured to store the intermediate image and / or the color image;

[0118] The body structure 5 is further provided with a data transmission port, and the data transmission port is configured to transmit the intermediate image and / or the color image to the outside;

[0119] In this solution, the data such as the image obtained in real time under the monochromatic light and the color image after the fusion processing are stored in the memory 12 in time, so as to facilitate the subsequent processing of the data and the like; in addition, some data stored in the memory 12 can be called through the data transmission port and transmitted to the external equipment for further viewing, processing and analysis and the like.

[0120] In an implementable solution, the imaging body 2 further comprises a power module 13 arranged in the body structure 5, and the power module 13 is configured to supply power to the contact imaging device.

[0121] In this solution, the power module 13 is arranged in the contact imaging device, so as to ensure the endurance time of the whole device and realize the portability of the contact imaging device.

[0122] In an implementable solution, the imaging body 2 further comprises a cooling mechanism 14 arranged in the body structure 5 and in communication connection with the controller 1, and the cooling mechanism 14 is configured to reduce the internal temperature of the imaging device;

[0123] The cooling mechanism 14 can be a fan, a semiconductor refrigerator and the like.

[0124] In this solution, the cooling mechanism 14 is configured to reduce the internal temperature of the contact imaging device, and the internal temperature of the contact imaging device can be reduced by arranging the cooling mechanism 14, so as to avoid the influence of the internal overheating of the contact imaging device on the stability of the imaging, thereby obtaining a better imaging image.

[0125] In an implementable solution, the imaging body 2 further comprises a wireless communication module 15 arranged in the body structure 5 and in communication connection with the controller 1, and the wireless communication module 15 is configured to perform wireless communication with the external communication equipment;

[0126] The wireless communication module 15 comprises a Bluetooth module and the like.

[0127] In this solution, the wireless communication module 15 is arranged in the contact imaging device, so as to more conveniently realize the data interaction with the external communication equipment, and further improve the intelligence and flexibility of the whole device.

[0128] In an implementable solution, the body structure 5 is further provided with a power supply interface, and the power supply interface is configured to be electrically connected with the external power supply to supply power to the power module 13;

[0129] In this solution, the contact imaging device can realize the power supply of the power module 13 by the wired mode based on the power supply interface.

[0130] In an implementable solution, the power module 13 comprises a wireless power supply module, which is used to wirelessly connect with the external power supply to wirelessly supply power to the power module 13.

[0131] In this solution, the contact imaging device can adopt the wireless power supply module, so as to realize the power supply of the power module 13 by the wireless mode, and achieve the effect of more convenient power supply.

[0132] In addition, in this embodiment, the hardware PCBA 14 (printed circuit board) is used to supply power to the adjustable light source module 4 and control the backlight to emit light of different colors under different instructions; when the Mark strip corresponding to the biological sample film is collected, the backlight emits light of the corresponding color, the light transmits through the biological sample film, the imaging module 6 collects the light to form the corresponding image; by analogy, after multiple different color light irradiation and collection, all images of the biological sample film corresponding to different monochromatic light are collected, and the images are calibrated and fused to finally obtain the color image corresponding to the biological sample film.

[0133] Embodiment 3

[0134] The contact imaging device of this embodiment is a further improvement of the contact imaging device of Embodiment 1 or 2, or can also exist independently. Specifically:

[0135] As shown in FIGS. 11-16, the contact imaging device of the present embodiment comprises a housing 100, which is the main body structure described above; the housing 100 comprises a first chamber 110, which is a darkroom space and is configured to be openable or closable, and a CMOS detector assembly 500 is arranged in the first chamber 110, which is used to convert the light signal generated by the detected sample into an image, and the CMOS detector assembly 500 is the imaging module described above; the housing 100 further comprises a second chamber 120 arranged below the first chamber 110, and a control mainboard 600 is arranged in the second chamber 120, and the control mainboard 600 is signal connected with the CMOS detector assembly 500; the housing 100 is further provided with an external port 400, which is electrically connected with the control mainboard 600, and the external port 400 is used to enable the contact imaging device to be operatively connected with external equipment. The light signal emitted by the biological sample film is received by the pixel array in the detection area of the CMOS detector assembly 500, and then converted into an electrical signal by the pixel array, and then the image information is output. By using the CMOS detector to contact the biological sample film for collection, the light signal loss is small, and the obtained image is relatively clear; by arranging the control mainboard 600, the contact imaging device can be operatively connected with external equipment, and the contact imaging device can be debugged in real time according to the displayed image, and the parameters can be adjusted. The control mainboard 600 can control the CMOS detector assembly 500 and other hardware devices of the contact imaging device, and a lower computer operating system is provided to facilitate the operable connection with external equipment.

[0136] The side length of the pixel array of the CMOS detector assembly 500 can be selected to be between 60mm-160mm according to requirements. Since the size of the biological sample film is mostly greater than 60mm, setting the side length of the pixel array to be between 60-160mm enables the contact imaging device to be applicable to biological sample films of various sizes, and also does not make the size of the CMOS detector too large and waste costs. The size of the pixel forming the pixel array can be selected to be between 25um-200um according to requirements, which can improve the light collection efficiency and electronic capacity while ensuring the resolution of the image.

[0137] The biological sample film to be imaged for detection is a high-molecular film or gel block carrying biological macromolecules, which can generate fluorescence under excitation of a laser. The high-molecular film or gel block carrying biological macromolecules can be a PVDF film carrying a protein sample, a nitrocellulose membrane carrying a protein detection sample, or a gel block carrying DNA / RNA or a gel block carrying protein.

[0138] In the embodiment, the external port 400 comprises interfaces for connecting with a mouse and a keyboard. By arranging the mouse and keyboard connection ports, it is convenient for the staff to debug the contact imaging device, conduct data transmission or adjust the imaging parameters of the contact imaging device through the mouse and keyboard. The external port 400 further comprises a power supply interface for supplying power to the contact imaging device. Specifically, an interface board 700 is arranged in the second chamber 120, and the interface board 700 is integrated with external interfaces (such as HDMI interface, VGA interface, USB interface, etc.), power supply interface, network interface, etc., and the interface board 700 is connected with the control mainboard 600.

[0139] In the embodiment, the contact imaging device further comprises a touch display screen 300, which is the aforementioned touch display screen; the touch display screen 300 is connected with the control mainboard 600. The control mainboard 600 is controlled through the touch display screen 300, and the imaging result can be displayed according to the requirement, so as to obtain the best imaging effect by adjusting the imaging parameters.

[0140] As shown in the figure, the touch display screen 300 and the external port 400 are arranged on the opposite sides of the shell 100. By adopting the above structure design, when the external equipment is connected, the external wires do not interfere with the touch display screen 300.

[0141] The contact imaging device of the embodiment is provided with the touch display screen 300 and the external interfaces of the mouse and keyboard, so that the user has another operable way to choose when operating, and can choose the appropriate operation mode according to the operation environment or operation habit.

[0142] As shown in the figure, the shell 100 is hinged with an upper cover 200, and the first chamber 110 is opened or closed to the darkroom space through the upper cover 200. The inner top surface of the upper cover 200 is provided with a backlight assembly for providing a light source for the CMOS detector assembly 500. Through the above structure design, the opening and closing of the darkroom space can be realized, the biological sample film to be imaged can be conveniently placed in the darkroom space, and the light source on the backlight assembly can facilitate the CMOS detector to collect the signal of the biological sample film to obtain the imaging image.

[0143] The control mainboard 600 is connected with the power supply of the backlight assembly, and is used for controlling the brightness of the light source. When the contact imaging device is used, the best imaging image can be obtained by controlling the brightness of the light source, so as to facilitate subsequent analysis.

[0144] The backlight assembly is integrally provided with a point-like LED lamp bead array (not shown in the figure), and the LED lamp beads are uniformly arranged to achieve uniform illumination. In order to achieve better illumination effect, other light sources such as lamp tubes, solid-state laser emitters or gaseous laser emitters can also be used. The corresponding illumination time of the LED lamp bead after being turned on is 10ms-1000ms, and the illumination time can also be adjusted according to actual needs.

[0145] In some embodiments, the backlight assembly is also provided with a light diffuser plate (not shown in the figure), which is fixed below the LED lamp bead array, so that the light emitted by the LED lamp bead array is more uniform, improving the imaging effect.

[0146] In the embodiment, the second chamber 120 is also provided with a cooling mechanism for reducing the internal temperature of the contact imaging device. By setting the cooling mechanism, the internal temperature of the contact imaging device can be reduced, avoiding the influence of the internal overheating of the contact imaging device on the stability of imaging, so that better imaging images can be obtained. The cooling mechanism can be a fan, a semiconductor cooler or the like, which can cool the control mainboard 600, the touch display screen 300 and the like, avoiding the overheating of the control mainboard 600, the touch display screen 300 and the like.

[0147] As shown in FIG. 16, the bottom plate 105 of the second chamber 120 of the contact imaging device is located above the plane of the support part 106 of the contact imaging device, and the bottom plate 105 of the second chamber 120 is provided with a ventilation hole 1051. As shown in FIGS. 12 and 16, the shell body 101 is provided with two air outlets 107 on the side opposite to the touch display screen 300, and the second chamber 120 is provided with two fans, and the air outlet side of the fan is opposite to the air outlet 107. When the fan works, the high-temperature air emitted from the inside of the contact imaging device is discharged from the air outlet 107, and the cooler air from the outside enters from the ventilation hole 1051, so that the inside of the contact imaging device is maintained at a lower temperature, thereby avoiding the influence of the internal overheating of the contact imaging device on the stability of imaging.

[0148] The CMOS detector assembly 500 includes a CMOS detector body 501, and a fiber panel and / or a protective film are arranged above the photosensitive area of the CMOS detector body 501. By arranging the fiber panel or the protective film, the CMOS detector body 501 is protected without affecting the imaging effect.

[0149] In the embodiment, the light-sensitive area of the CMOS detector body 501 is provided with a fiber panel 502, and the fiber panel 502 is provided with a protective film (not shown in the figure). Since the fiber panel 502 has the advantages of small light loss and total reflection, no matter how thick the fiber panel is, it will not affect the imaging effect of the sample film on the CMOS detector. Since the fiber panel 502 is quartz optical fiber glass, the quartz optical fiber glass is pressed by countless optical fiber tubes, each of which has a core and a cladding, wherein the core is quartz glass, and the cladding is used to produce total reflection of the light entering the optical fiber tube to achieve transmission of the light. The thickness of the protective film is between 0.01 mm and 2 mm, and the material of the protective film can be tempered glass film or hard plastic film.

[0150] In other embodiments, only the fiber panel 502 or the protective film can be provided to protect the CMOS detector body 501.

[0151] In the embodiment, the specific structure of the contact imaging device is shown in Figures 12-13. The housing 100 of the contact imaging device includes a housing body 101, and the upper side of the housing body 101 is provided with a device middle frame 102 having a hinge shaft mounting portion hingedly connected with an upper cover 200. The upper cover 200 is hingedly connected to the hinge shaft mounting portion. A shielding cover 104 is arranged below the device middle frame 102 and is fixedly connected with the device middle frame 102. The shielding cover 104 is fixedly provided with a CMOS detector assembly 500. The CMOS detector assembly 500 includes a CMOS detector body 501, and the light-sensitive area of the CMOS detector body 501 is provided with a fiber panel 502. The fiber panel 502 is provided with a protective film. The middle part of the device middle frame 102 is hollow. The lower surface of the inner periphery of the device middle frame 102 is pressed on the fiber panel 502. An elastic sealing ring 900 is arranged between the fiber panel 502 and the lower surface of the inner periphery of the device middle frame 102. By arranging the elastic sealing ring 900, on the one hand, the sealing between the fiber panel 502 above the CMOS detector body 501 and the lower surface of the inner periphery of the device middle frame 102 can be ensured, and on the other hand, the influence of the micro-vibration generated by the contact imaging device during operation on the CMOS detector assembly 500 can be reduced, thereby avoiding the influence of the vibration of the contact imaging device on the imaging stability. The upper surface of the device middle frame 102 is also provided with a sealing member 800. The sealing member 800 can ensure that the darkroom space is absolutely closed when the upper cover 200 is closed, thereby ensuring the imaging effect. The housing 100, the upper cover 200, the shielding cover 104, etc. of the contact imaging device are made of light-proof materials or are coated with light-proof coatings.

[0152] Although specific embodiments of the disclosure have been described above, those skilled in the art will understand that these are merely examples and that various changes or modifications can be made thereto without departing from the principles and spirit of the disclosure. Accordingly, the scope of protection of the present disclosure is defined by the appended claims.

Claims

1. A contact image forming device, characterized by, The contact imaging device comprises a controller, an imaging body, a cover and an adjustable light source module; The imaging body comprises a body structure and an imaging module arranged on the body structure, and the imaging module is used for placing a biological sample film; the adjustable light source module is arranged on the inner side of the cover, and the adjustable light source module and the imaging module are in communication connection with the controller; When the cover is arranged on the imaging body to form a darkroom state, the controller is used for sending different driving instructions to the adjustable light source module at different collection time points to drive the adjustable light source module to emit light signals of matching colors respectively; The imaging module is used for collecting intermediate images of the biological sample film under the light signals at each collection time point to output corresponding color images of the biological sample film.

2. The contact printing device of claim 1, wherein, The adjustable light source module and the controller are in communication connection through a plurality of communication cables; Different communication cables pass through different driving instructions to drive the adjustable light source module to emit light signals of different colors.

3. The contact imaging device of claim 1 or 2, wherein The adjustable light source module comprises a light-emitting auxiliary component and a light-emitting component; The light-emitting component is a backlight source capable of emitting light of different colors; The light-emitting component is arranged in a recess structure on the inner side of the cover according to a preset distribution mode, and the light-emitting auxiliary component is arranged on the cover and covers the light-emitting component in the recess structure.

4. The contact printing device of claim 3, wherein, The light-emitting auxiliary component comprises a light guide plate and / or a light uniform plate; And / or, the light-emitting component comprises a plurality of lamp beads and / or a light-emitting screen.

5. The contact imaging device of claim 3 or 4, wherein The arrangement position of the light-emitting component is matched and set based on the preset placement position of the biological sample film.

6. The contact imaging device of any one of claims 3-5, wherein, When the light-emitting component comprises a plurality of lamp beads, the plurality of lamp beads are uniformly distributed in a structure area of the recess structure, and the structure area is arranged corresponding to the imaging of the imaging module.

7. The contact imaging device of any one of claims 1-6, wherein, Different light illumination collection sequences correspond to different light illumination color combinations. And / or, The imaging module is used for detecting signals projected after the light signals emitted by the adjustable light source module irradiate the biological sample film to obtain the intermediate images corresponding to the collection time points.

8. The contact imaging device of any one of claims 1-6, wherein, The controller is arranged in the body structure, and the imaging body further comprises a touch display screen arranged on the body structure and in communication connection with the controller; And / or, The imaging body further comprises an external port, and the external port comprises an interface connected with a mouse and / or a keyboard.

9. The contact imaging device of any one of claims 1-8, wherein, The imaging body further comprises a memory arranged in the body structure, and the memory is used for storing the intermediate images and / or the color images; The body structure further comprises a data transmission port, and the data transmission port is used for transmitting the intermediate images and / or the color images to the outside; And / or, The imaging body further comprises a power module arranged in the body structure, and the power module is used for supplying power to the contact imaging device.

10. The contact image forming device of any one of claims 1-8, wherein, The imaging body further comprises a cooling mechanism arranged in the body structure and connected with the controller in communication, the cooling mechanism being used for reducing the internal temperature of the imaging device; and / or, The imaging body further comprises a wireless communication module arranged in the body structure and connected with the controller in communication, the wireless communication module being used for wireless communication with an external communication device; and / or, The body structure is further provided with a power supply interface, the power supply interface being used for electrical connection with an external power supply to supply power to the power supply module; and / or, The power supply module comprises a wireless power supply module, the wireless power supply module being used for wireless connection with an external power supply to supply power to the power supply module wirelessly.

11. The contact image formation device of any one of claims 1-10, wherein, The shell comprises a first chamber, which is a darkroom space and is arranged to be openable or closable, and an imaging assembly arranged in the first chamber, the imaging assembly being used for converting a light signal generated by a detected sample into an image. The shell further comprises a second chamber arranged below the first chamber, and a control mainboard arranged in the second chamber and connected with the imaging assembly in signal, and an external port arranged on the shell and connected with the control mainboard in electricity, the external port being used for operable connection of the contact-type imaging device with an external device.

12. A contact image forming device, characterized by comprising: The shell comprises a first chamber, which is a darkroom space and is arranged to be openable or closable, and an imaging assembly arranged in the first chamber, the imaging assembly being used for converting a light signal generated by a detected sample into an image. The shell further comprises a second chamber arranged below the first chamber, and a control mainboard arranged in the second chamber and connected with the imaging assembly in signal, and an external port arranged on the shell and connected with the control mainboard in electricity, the external port being used for operable connection of the contact-type imaging device with an external device.

13. The contact imaging device of any one of claims 1-12, wherein, The external port comprises an interface connected with a mouse and a keyboard.

14. The contact imaging device of any one of claims 1-13, wherein, The contact-type imaging device further comprises a touch display screen connected with the control mainboard.

15. The contact image forming device of claim 14, wherein, The touch display screen and the external port are arranged on opposite sides of the shell.

16. The contact imaging device of any one of claims 1-13, wherein, The shell is hingedly provided with an upper cover, and the first chamber opens or closes the darkroom space through the upper cover. An inner top surface of the upper cover is provided with a backlight plate assembly, the backlight plate assembly being used for providing an imaging light source for the imaging assembly.

17. The contact image forming device of claim 16, wherein, The control mainboard is connected with a power supply on the backlight plate assembly and is used for controlling the brightness of the light source.

18. The contact image forming device of claim 16 or 17, wherein, The light source on the backlight plate assembly is arranged to emit light of different colors.

19. The contact imaging device of any one of claims 1-13, wherein, The second chamber is further provided with a cooling mechanism, the cooling mechanism being used for reducing the internal temperature of the contact-type imaging device.

20. The contact image forming device of claim 19, wherein, A bottom plate of the second chamber is located above a plane on which a support portion of the contact-type imaging device is located, and the bottom plate of the second chamber is provided with a ventilation hole.

21. The contact imaging device of any one of claims 1-13, wherein, A light fiber panel and / or a protective film is arranged on an upper light sensing area of the imaging assembly.

Images