Combination therapy for treatment of metabolic disorders and inflamation related disorders using incretin compounds and CD38 inhibitors

Abstract

The present application relates to the use of cyclic adenosine diphosphate (ADP) ribose hydrolase (CD38) inhibitors and enteroendocrine-pancreatic hormone pathway modulators for preventing or treating diseases and disorders of metabolism.

Description

COMBINATION THERAPY FOR TREATMENT OF METABOLIC DISORDERS AND INFLAMATION RELATED DISORDERS USING INCRETIN COMPOUNDS AND CD38 INHIBITORSCROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application is related to and claims the benefit of priority of U.S. Provisional Patent Application serial number 63 / 701,941, filed October 1, 2024, which is incorporated by reference herein in its entirety.FIELD OF INVENTION

[0002] The present application relates to the use of cyclic adenosine diphosphate (ADP) ribose hydrolase (CD38) inhibitors and enteroendocrine-pancreatic hormone pathway modulators for preventing or treating diseases and disorders of metabolism.BACKGROUND

[0003] Diseases and disorders of metabolism continue to be more frequently observed and diagnosed in the population. In particular, obesity is a metabolic disease that affects more than one in three adults in the United States alone. Obesity also increases the risk of additional diseases and disorders of metabolism, such as type 2 diabetes, kidney disease, cardiovascular disease, or metabolic liver disease.

[0004] Recently, semaglutide (available as WEGOVY®, 2.4 mg once-weekly subcutaneous injection) was approved by the U.S. Food and Drug Administration (FDA) for chronic weight management in adults with obesity or who are overweight with at least one weight-related condition (such as high blood pressure, type 2 diabetes, and high cholesterol), to be used in addition to a reduced calorie diet and increased physical activity.

[0005] Diseases and disorders of metabolism, particularly obesity, can be caused by or be characterized by abnormal glucose metabolism. Nicotinamide adenine dinucleotide (NAD), a biochemical that is found in all cells, is a key participant in monitoring the metabolic status of the cell. Increasing NAD levels, either by upregulating the production of NAD, or downregulating the consumption of NAD, can likely have medical benefits in diseases or disorders associated with metabolic dysfunction such as those that may be caused by or characterized by abnormal nutrient (e.g., carbohydrates such as glucose, fats, fatty acids, proteins, and / or micronutrients) metabolism. CD38 (i.e. , cluster of differentiation 38) is a glycoprotein that catalyzes the conversion of nicotinamide adenine dinucleotide (NAD) into adenosine diphosphate ribose (ADPR) or cyclic adenosine diphosphate ribose (cADPR). Inhibition of CD38, which woulddownregulate the consumption of NAD, thus represents a way to increase cellular NAD levels and provide medical benefits in diseases or disorders caused by or characterized by abnormal glucose metabolism through a pathway that is orthogonal to existing treatment options such as semaglutide.

[0006] Accordingly, there exists a need for combination therapies for subjects suffering from metabolic diseases and / or disorders.SUMMARY

[0007] Provided herein are methods for preventing or treating disesases and disorders of metabolism. Accordingly, in one aspect, the present disclosure provides a method of treating or preventing a metabolic disorder or disease in a subject in need thereof. In other aspects and embodiments, the present disclosure provides a method of treating or preventing a metabolic disorder associated with, caused by or characterized by abnormal nutrient metabolism. In further aspects and embodiments, the present disclosure provides a method of treating or preventing a disorder or disease that is associated with metabolic dysfunction and / or metabolic syndrome. In yet further aspects and embodiments, the present disclosure provides a method of treating or preventing a disorder or disease associated, with, caused by, or characterized by abnormal glucose metabolism. In any of the above aspects and embodiments of the methods described herein, the methods comprise: administering to the subject a therapeutically effective amount of a cyclic ADP ribose hydrolase (CD38) inhibitor and a therapeutically effective amount of a enteroendocrine-pancreatic hormone pathway modulator.

[0008] Yet further aspects and embodiments in accordance with the disclosure will be apparent to those of skill in the art in light of the detailed description that follows.DETAILED DESCRIPTION

[0009] Before the disclosed processes and materials are described, it is to be understood that the aspects described herein are not limited to specific embodiments, and as such can, of course, vary. It is also to be understood that the terminology used herein is for the purpose of describing particular aspects only and, unless specifically defined herein, is not intended to be limiting.

[0010] Definitions

[0011] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as is commonly understood by one of skill in the art to which this invention belongs. All patents, patent applications, and publications referred to herein are incorporated by reference to the extent they are consistent with the present disclosure. Terms and ranges have their generally defined meanings unless expressly defined otherwise.

[0012] For simplicity, chemical moieties are defined and referred to throughout primarily as univalent chemical moieties (e.g., alkyl, aryl, etc.). Nevertheless, such terms may also be used to convey corresponding multivalent moieties under the appropriate structural circumstances clear to those skilled in the art. For example, while an “alkyl” moiety generally refers to a monovalent radical (e.g. CH3-CH2-), in certain circumstances a bivalent linking moiety can be “alkyl,” in which case those skilled in the art will understand the alkyl to be a divalent radical (e.g., -CH2-CH2-), which is equivalent to the term “alkylene.” Similarly, in circumstances in which a divalent moiety is required and is stated as being “aryl,” those skilled in the art will understand that the term “aryl” refers to the corresponding divalent moiety, arylene. All atoms are understood to have their normal number of valences for bond formation (i.e. , 4 for carbon, 3 for N, 2 for O, and 2, 4, or 6 for S, depending on the oxidation state of the S).

[0013] The term “acetyl” refers to -C(O)CH3.

[0014] As herein employed, the term “acyl” refers to an alkylcarbonyl or arylcarbonyl substituent wherein the alkyl and aryl portions are as defined herein.

[0015] The term “alkyl” as employed herein refers to saturated straight and branched chain aliphatic groups having from 1 to 12 carbon atoms. As such, “alkyl” encompasses Ci, C2, C3, C4, C5, Ce, C7, Cs, C9, C10, C11, and C12 groups. Alkyl groups may be branched or unbranched. Examples of alkyl groups include, without limitation, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, and hexyl.

[0016] The term “amino” refers to -NH2. The term “aminoalkyl” refers to -alkylene-NH2.

[0017] The terms “cyano” and “nitrile” refer to -C=N. The term “cyanoalkyl” refers to -alkylene-CN.

[0018] The term “sulfonyl” refers to -S(O)2- that is positioned between and serves to connect two other chemical groups. The term “alkylsulfonyl” refers to -S(O)2_(alkyl).

[0019] The term “alkenyl" as used herein means an unsaturated straight or branched chain aliphatic group with one or more carbon-carbon double bonds, having from 2 to 12 carbonatoms. As such, “alkenyl” encompasses C2, C3, C4, C5, Ce, C7, Ce, C9, C10, C11, and C12 groups. Examples of alkenyl groups include, without limitation, ethenyl, propenyl, butenyl, pentenyl, and hexenyl.

[0020] The term “alkynyl" as used herein means an unsaturated straight or branched chain aliphatic group with one or more carbon-carbon triple bonds, having from 2 to 12 carbon atoms. As such, “alkynyl” encompasses C2, C3, C4, C5, Ce, C7, Cs, C9, C10, C11, and C12 groups.Examples of alkynyl groups include, without limitation, ethynyl, propynyl, butynyl, pentynyl, and hexynyl.

[0021] An “alkylene,” “alkenylene,” or “alkynylene” group is an alkyl, alkenyl, or alkynyl group, as defined hereinabove, that is positioned between and serves to connect two other chemical groups. Examples of alkylene groups include, without limitation, methylene, ethylene, propylene, and butylene. Examples of alkenylene groups include, without limitation, ethenylene, propenylene, and butenylene. Examples of alkynylene groups include, without limitation, ethynylene, propynylene, and butynylene.

[0022] The terms “alkoxy” and “ether” refer to -O-alkyl.

[0023] The terms “alkylthio” and “thioether” refer to -S-alkyl. The term “alkoxy(alkylthio)” refers to an alkylthio group in which at least one hydrogen atom is replaced with an alkoxy group. The term “haloalkylthio” refers to an alkylthio group in which at least one hydrogen atom is replaced with a halogen.

[0024] The terms “cycloalkyl” and “carbocycle” as employed herein each refer to a saturated and partially unsaturated cyclic hydrocarbon group having 3 to 14 carbons. As such, “cycloalkyl” and “carbocycle” include C3, C4, C5, Ce, C7, Cs, C9, C10, C11, C12, C13, and C14 cyclic hydrocarbon groups. Examples of cycloalkyl groups include, without limitation, cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, and cyclooctyl. A “cycloalkyl” group also includes fused multicyclic (e.g., bicyclic) ring systems such as decahydronaphthyl and octahydro-1 H-indenyl, provided that at least one of the fused rings is non-aromatic.

[0025] The term “C3-C6 cycloalkyloxy” refers to groups of the formula -O(C3-Ce cycloalkyl).

[0026] The term Ci-Ce alkoxyalkyl refers to groups of the formula -(Ci-Ce alkyl)-O(Ci-Ce alkyl).

[0027] An “aryl” group is a C6-C14 aromatic moiety comprising one to three aromatic rings. As such, “aryl” includes Ce, C10, C13, and C14 cyclic hydrocarbon groups. A representative arylgroup is a Ce-Cio aryl group. Particular aryl groups include, without limitation, phenyl, naphthyl, anthracenyl, and fluorenyl. An “aryl” group also includes fused multicyclic (e.g., bicyclic) ring systems in which one or more of the fused rings is non-aromatic, provided that at least one ring is aromatic, such as indenyl.

[0028] An “aralkyl” or “arylalkyl” group comprises an aryl group covalently linked to an alkyl group wherein the moiety is linked to another group via the alkyl moiety. An representative aralkyl group is -(Ci-C6)alkyl(C6-Cio)aryl, including, without limitation, benzyl, phenethyl, and naphthyl methyl. For example, an arCi-Csalkyl is an aryl group covalently linked to a C1-C3 alkyl.

[0029] As used herein, the term “fused” when used to define rings, e.g., bicyclic fused ring systems, refers to bicyclic, tricyclic, etc. ring systems sharing 2 or more atoms, including bridged systems. Examples of such fused ring systems are (1S,4R)-2-azabicyclo[2.2.1]heptane; 2- azabicyclo[2.2.2]octane; 2,5-diazabicyclo[2.2.2]octane; 2-oxa-5-azabicyclo[2.2.2]octane; isoindoline; 1 ,2,3,4-tetrahydro-2,6-naphthyridine; 1,2,3,4-tetrahydroisoquinoline; 1 , 2,3,4- tetrahydro-1 ,4-(epiminomethano)naphthalene; and 3-azabicyclo[3.1 .Ojhexane.

[0030] A “heterocyclyl” or “heterocyclic” or “heterocycloalkyl” group is a mono- or bicyclic (e.g., fused) ring structure having from 3 to 12 atoms, (3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 atoms), for example 4 to 8 atoms, wherein one or more ring atoms are independently N, O, or S, and the remainder of the ring atoms are quaternary or carbonyl carbons. Examples of heterocyclic groups include, without limitation, epoxy, oxiranyl, oxetanyl, azetidinyl, aziridinyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothiophenyl, pyrrolidinyl, piperidinyl, piperazinyl, imidazolidinyl, thiazolidinyl, thiatanyl, dithianyl, trithianyl, azathianyl, oxathianyl, dioxolanyl, oxazolidinyl, oxazolidinonyl, decahydroquinolinyl, piperidonyl, 4-piperidonyl, thiomorpholinyl, dimethyl-morpholinyl, and morpholinyl. Specifically excluded from the scope of this term are compounds having adjacent ring O and / or S atoms. The heterocyclic groups can be attached to a parent group (i.e., the point of attachment) via any ring atom, including one of the heteroatoms or one of the carbon atoms, in the heterocyclic ring group. As chemically required, the heterocyclic ring may be attached to one or more other groups, for instance if operating as a bridging group. The term “heterocyclyl” also includes fused multicyclic (e.g., bicyclic) ring systems in which one or more of the fused rings is aromatic or non-aromatic, provided that at least one ring is non-aromatic contains an N, O, or S ring atom. Examples of such fused multicyclic ring systems are indolinyl, indolin-2-yl, 2,3-dihydrobenzofuran-2-yl, and 2, 3,4,5- tetrahydrobenzo[d]oxazol-2-yl. Each of these examples is a 9-membered heterocyclyl.

[0031] As used herein, the term “heteroaryl” refers to a group having 5 to 14 ring atoms, preferably 5, 6, 10, 13, or 14 ring atoms; having 6, 10, or 14 IT electrons shared in a cyclic array; and having, in addition to carbon atoms, from one to three heteroatoms that are each independently N, O, or S. “Heteroaryl” also includes fused multicyclic (e.g., bicyclic) ring systems in which one or more of the fused rings is non-aromatic, provided that at least one ring is aromatic and at least one ring contains an N, O, or S ring atom. The heteroaryl groups can be attached to a parent group (i.e. , the point of attachment) via any ring atom, including one of the heteroatoms or one of the carbon atoms, in the heteroaryl ring group. As chemically required, the heteroaryl may be attached to one or more other groups, for instance if operating as a bridging group.

[0032] Examples of heteroaryl groups include acridinyl, azocinyl, benzimidazolyl, benzofuranyl, benzo[d]oxazol-2(3H)-one, 2H-benzo[b][1,4]oxazin-3(4H)-one, benzothiofuranyl, benzothiophenyl, benzoxazolyl, benzthiazolyl, benztriazolyl, benztetrazolyl, benzisoxazolyl, benzisothiazolyl, benzimidazolinyl, carbazolyl, 4aH-carbazolyl, carbolinyl, chromanyl, chromenyl, cinnolinyl, furanyl, furazanyl, imidazolinyl, imidazolyl, 1H-indazolyl, indolenyl, indolinyl, indolizinyl, indolyl, 3H-indolyl, isobenzofuranyl, isochromanyl, isoindazolyl, isoindolinyl, isoindolyl, isoquinolinyl, isothiazolyl, isoxazolyl, naphthyridinyl, octahydroisoquinolinyl, oxadiazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, oxazolidinyl, oxazolyl, oxazolidinyl, pyrimidinyl, phenanthridinyl, phenanthrolinyl, phenazinyl, phenothiazinyl, phenoxathiinyl, phenoxazinyl, phthalazinyl, piperonyl, pteridinyl, purinyl, pyranyl, pyrazinyl, pyrazolidinyl, pyrazolinyl, pyrazolyl, pyridazinyl, pyridooxazole, pyridoimidazole, pyridothiazole, pyridinyl, pyridyl, pyrimidinyl, pyrrolinyl, 2H-pyrrolyl, pyrrolyl, quinazolinyl, quinolinyl, 4H-quinolizinyl, quinoxalinyl, quinuclidinyl, tetrahydroisoquinolinyl, tetrahydroquinolinyl, tetrazolyl, 6H-1,2,5-thiadiazinyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5- thiadiazolyl, 1,3,4-thiadiazolyl, thianthrenyl, thiazolyl, thienyl, thienothiazolyl, thienooxazolyl, thienoimidazolyl, thiophenyl, triazinyl, 1 ,2,3-triazolyl, 1,2,4-triazolyl, 1 ,2,5-triazolyl, 1 ,3,4-triazolyl, and xanthenyl.

[0033] An “arylene,” “heteroarylene,” or “heterocyclylene” group is a bivalent aryl, heteroaryl, or heterocyclyl group, respectively, as defined hereinabove, that is positioned between and serves to connect two other chemical groups.

[0034] As employed herein, when a moiety (e.g., cycloalkyl, aryl, heteroaryl, heterocyclyl, urea, etc.) is described as “optionally substituted” without expressly stating the substituents, it ismeant that the group optionally has multiple non-hydrogen substituents, for example, from one to five, or from one to four, or from one to three, or one, or two non-hydrogen substituents.

[0035] The term “halogen” or “halo” as employed herein refers to chlorine, bromine, fluorine, or iodine.

[0036] The term “haloalkyl” refers to an alkyl chain in which one or more hydrogens have been replaced by a halogen. Representative haloalkyls are trifluoromethyl, difluoromethyl, fluorochloromethyl, chloromethyl, and fluoromethyl. The term “fluoroalkyl” refers to an alkyl chain in which one or more hydrogens have been replaced by a fluorine. Representative haloalkyls are trifluoromethyl, difluoromethyl, and trifluoroethyl,

[0037] The term “haloalkoxy” refers to -O-alkyl, wherein the alkyl chain in which one or more hydrogens have been replaced by a halogen. Representative haloalkoxy are trifluoromethoxy, difluoromethoxy, and trifluoroethoxy.

[0038] The term “hydroxyl” refers to -OH. The term “hydroxyalkyl” refers to -alkylene-OH.

[0039] The term “oxo” refers to =0. As used herein, a compound bearing an oxo substituent is understood to refer to a tautomer or resonance structure that results in a stable or chemically feasible compound. As used herein, can be represented by (O). Representative examples include acyl (i.e., -C(O)R) and sulfonyl (i.e., -S(O)2R) substituents.

[0040] The term "substituted", as used herein, means that a hydrogen radical of the designated moiety is replaced with the radical of a specified substituent, provided that the substitution results in a stable or chemically feasible compound. The term "substitutable", when used in reference to a designated atom, means that attached to the atom is a hydrogen radical, which can be replaced with the radical of a suitable substituent.

[0041] The phrase "one or more” substituents, as used herein, refers to a number of substituents that equals from one to the maximum number of substituents possible based on the number of available bonding sites, provided that the above conditions of stability and chemical feasibility are met. Unless otherwise indicated, an optionally substituted group may have a substituent at each substitutable position of the group, and the substituents may be either the same or different. As used herein, the term "independently selected" means that the same or different values may be selected for multiple instances of a given variable in a single compound.

[0042] It is to be understood that each individual atom present in Formulae (I) to (XXIo) and the compounds within Formulae (I) to (XXIo), may be present in the form of any of its naturallyoccurring isotopes, with the most abundant isotope(s) being preferred. Thus, by way of example, each individual hydrogen atom present in Formula (I), or in the formulae depicted hereinafter, may be present as a1H,2H (deuterium; D), or3H (tritium; T) atom, preferably1H. Similarly, by way of example, each individual carbon atom present in formula (I), or in the formulae depicted hereinafter, may be present as a12C,13C, or14C atom, preferably12C.

[0043] The terms “enteroendocrine-pancreatic hormone pathway modulator” and “modulator of an enteroendocrine-pancreatic hormone signalling pathway” can be used interchangeably herein, and encompass any agent (e.g., small molecules, peptides, peptide mimetics, antibodies, and hormones, and / or derivatives thereof) that, through binding to an enteroendocrine hormone receptor, can modulate (i.e., activate or inhibit) one or more of the biochemical pathways that involve endogenous gastrointestinal hormones that are secreted by enteroendocrine cells located in the gastrointestinal tract (e.g., stomach, large and small intestines) and pancreas, and that have endocrine function. Non-limiting examples of enteroendocrine cells include gastric enteroendocrine cells, intestinal enteroendocrine cells, and pancreatic enteroendocrine cells such as K cells, L cells, I cells, G cells, enterochromaffin cells, enterochromaffin-like cells, N cells, S cells, D cells, and / or M or Mo cells. Non-limiting examples of endogenous gastrointestinal hormones include glucagon-like peptide-1 (GLP-1), glucagon (GCG), gastric inhibitory peptide (GIP), oxyntomodulin (OXYN), peptide YY (PYY), amylin, and insulin. Thus, the term “enteroendocrine hormone pathway modulator” includes any agent (e.g., small molecules, peptides, and hormones, and / or derivatives thereof) that can act as an agonist or antagonist of a receptor for one or more endogenous gastrointestinal peptides and / or hormones such as, for example, GLP-1, GCG, GIP, OXYN, PYY, amylin, and insulin. Thus, enteroendocrine hormone pathway modulators falling within the scope of the disclosure include exogenously-administered gastrointestinal hormones such as GLP-1, GCG, GIP, OXYN, PYY, amylin, and insulin, as well as analogs, derivatives, and mimetics thereof.

[0044] Other additional agents that can act through a different mechanism of action (i.e., that do not bind a receptor for endogenous gastrointestinal peptides and / or hormones) to exert an antagonist or agonist effect on an enteroendocrine hormone pathway can be used in accordance with the methods disclosed herein. Such agents may act in the signalling pathway either upstream or downstream of the enteroendocrine hormone receptor, or adjacent to the enteroendocrine hormone receptor signalling pathway (e.g., additive and / or synergistic activity). The activity of such agents may arise from, for example, increasing or decreasing the degree of activity, the duration of activity, or the availability of one or more components of the signalingpathway, etc. In some embodiments, the agents can modulate upstream regulators of one or more enteroendocrine hormone (e.g., dipeptididyl peptidase (DPP IV) inhibitors). In some embodiments, the agents can regulate the amount or activity of one or more enteroendocrine hormones (e.g., agents that increase or decrease production of or secretion of a hormone; hormone stabilizers / proteolytic enzymes). In some embodiments, the agents can increase or decrease activation of the enteroendocrine hormone receptor. In some embodiments, the agents can activate or inhibit signaling downstream of the receptor (e.g., activators / inhibitors of PI3K, PKC, cAMP, etc.). In some embodiments, the agents can modulate receptor expression and / or trafficking. Some non-limiting examples of such additional agents include a dipeptidyl peptidase-4 (DPP-4) inhibitor, a cyclic adenosine monophosphate (cAMP) activator, a protein kinase A (PKA), an exchange protein activated by cAMP (EPAC) activator, a Beta-adrenergic receptor (P-AR) agonist, a growth / differentiation factor 15 (GDF15) agonist, a cAMP responsive element binding (CREB) activator, a leptin sensitizer, or an epidermal growth factor receptor (EGFR) agonist.

[0045] As used herein, a “nutrient” includes any macronutrient such as, for example, carbohydrates, fats, and proteins, and any micronutrients and / or trace nutrients such as, for example, vitamins and minerals, and any and all metabolites and derivatives thereof. Nutrients may be essential or non-essential.

[0046] As used herein, “an effective amount” of a compound, with reference to a CD38 inhibitor, is an amount that is sufficient to negatively modulate or inhibit the activity of CD38. The term “an effective amount” with reference to an enteroendocrine-pancreatic hormone pathway modulator, is an amount that is sufficient either to inhibit (when the modulator is an antagonist) or promote (when the modulator is an agonist) the activity of a receptor for one or more endogenous gastrointestinal hormones that are secreted by enteroendocrine cells.

[0047] As used herein, a “therapeutically effective amount” of a compound, with reference to a CD38 inhibitor, is an amount that is sufficient to ameliorate or in some manner reduce a symptom or stop or reverse progression of a condition, or negatively modulate or inhibit the activity of CD38. The term, a “therapeutically effective amount” of a compound, with reference to an enteroendocrine-pancreatic hormone pathway modulator, is an amount that is sufficient either to inhibit (when the modulator is an antagonist) or to promote (when the modulator is an agonist) the activity of a receptor for one or more endogenous gastrointestinal hormones that are secreted by enteroendocrine cells. Such amount may be administered as a single dosage or may be administered according to a regimen, whereby it is effective.

[0048] As used herein, “treatment” means any manner in which the symptoms or pathology of a condition, disorder or disease in a patient are ameliorated or otherwise beneficially altered.

[0049] As used herein, “methods of treatment” are equally applicable to use of one or more compositions for treating the diseases or disorders described herein and / or compositions for use and / or uses in the manufacture of a medicaments for treating the diseases or disorders described herein.

[0050] In view of the present disclosure, the methods described herein can be configured by the person of ordinary skill in the art to meet the desired need. In general, the disclosed methods provide improvements in the treatment of metabolic disorders and diseases, particuarlly obesity, capitalizing on the synergistic effect arising from CD38 inhibitors and enteroendocrine-pancreatic hormone pathway modulators targeting orthogonal biological pathways.

[0051] In a broad aspect, the disclosure provides a method of treating or preventing a metabolic disorder or disease in a subject associated with, caused by, or characterized by abnormal nutrient metabolism, the method comprising: administering to the subject a therapeutically effective amount of a cyclic ADP ribose hydrolase (CD38) inhibitor and a therapeutically effective amount of a enteroendocrine-pancreatic hormone pathway modulator.

[0052] CD38 Inhibitors

[0053] As described above, disclosed are methods of treating or preventing a metabolic disorder or disease in a subject comprising administering to the subject a therapeutically effective amount of a cyclic ADP ribose hydrolase (CD38) inhibitor. As used herein, a CD38 inhibitor refers to a compound that can bind to the active site of CD38 and modulate cellular nicotinamide adenine dinucleotide (NAD+) levels. In accordance with the methods disclosed herein, NAD can help regulate nutrient utilization and metabolic homeostasis by exerting an effect on enzymes that are involved in nutrient metabolism. For example, NAD+ can i) transfer energy from food (nutrients) to cellular energy, ii) participate in redox reactions that lead to formation of ATP, iii) regulate enzymes that modify proteins in a way that modifies protein activity, and iv) act as a signaling molecule involved in a number of significant biochemical processes (e.g., cell survival and energy metabolism).

[8054] In certain embodiments, the CD38 inhibitor is a compound as disclosed in International Patent Publication No. WO 2023 / 235880, which is herein incorporated by reference in itsentirety. For example, in various embodiments, the CD38 inhibitor is is a compound of formula (I):or a pharmaceutically acceptable salt thereof, wherein:R1is selected from N and CR11;R2is selected from N and CR12;R3is selected from hydrogen, halogen, -CN, -OR16, -SO2R16, Ci-Ce alkyl, C3-C12 cycloalkyl, and 3- to 12-membered heterocyclyl, wherein the Ci-Ce alkyl, C3-C12 cycloalkyl, and 3- to 12- membered heterocyclyl are each optionally substituted with one or more substituents independently selected from halogen, -OH, -CN, -NO2, -NH2, -NH(Ci-Cio alkyl), -N(Ci-Cio alkyl)2, -C1-C10 haloalkyl, -0(Ci-Cio alkyl), Ci-Ce alkyl, C2-C10 alkenyl, C2- C10 alkynyl, C3-C12 cycloalkyl, and 3- to 12-membered heterocyclyl;R4is selected from a 5- to 6- membered heteroaryl, wherein the 5- to 6- membered heteroaryl is selected from imidazolyl, thiazolyl, oxazolyl, pyrimidinyl, pyrazinyl, pyridazinyl, oxadiazolyl, and thiadiazolyl, each of which is optionally substituted with one or more R9;R5is selected from hydrogen and Ci-Ce alkyl; R7is selected from an optionally substituted saturated 4- to 8-membered heterocyclyl, optionally substituted C3-C5 cycloalkyl, optionally substituted C7-C10 cycloalkyl, and substituted Ce cycloalkyl, wherein the 4- to 8-membered heterocyclyl, C3-C5 cycloalkyl, and C7-C10 cycloalkyl are each optionally substituted with one or more R8, and the Ce cycloalkyl is substituted with one or more R8A, and the Ce cycloalkyl is further optionally substituted with one or more R8B;R8is independently selected at each occurrence from halogen, -OR20, -SR20, -N(R21)2, -NO2, =0, =S, =N(R20), -CN, Ci-Ce aminoalkyl, Ci-Ce hydroxyalkyl, Ci-Ce cyanoalkyl, Ci-Ce haloalkyl, Ci-Ce alkoxyalkyl, Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, -C(O)R20, -C(O)OR20, -C(O)N(R21)2, -N(R21)C(O)R20, -N(R21)C(O)N(R21)2J-S(O)2(R20), -S(O)(R20), -S(O)2(NR202), -S(O)(NR21)R20, -S(O)(NR21)N(R21)2, and 4- to 8-membered heterocyclyl; wherein when R4is imidazolyl, R3is hydrogen, R7is pyrrolidinyl substituted with oxo and haloalkyl, the haloalkyl is selected from Ci haloalkyl and C3-6 haloalkyl; andwherein when R1is N, R3is imidazole, R7is C4 cycloalkyl, and R8is -OR20, the Ci-Ce alkyl of R20is selected from Ci alkyl and C3-C6 alkyl;R8Ais independently selected at each occurrence from halogen, Ci-Ce haloalkyl, -C(O)R20, -C(O)OR20, -C(O)N(R21)2, -N(R21)C(O)R20, -N(R21)C(O)N(R21)2J-S(O)2(R20), -S(O)(R20), -S(O)2(NR202), -S(O)(NR21)R20, and -S(O)(NR21)N(R21)2;R8Bis independently selected each occurrence from -OR20, -SR20, -N(R21)2, -NO2, =0, =S, =N(R20), -CN, Ci-Ce aminoalkyl, Ci-Ce hydroxyalkyl, Ci-Ce cyanoalkyl, Ci-Ce haloalkyl, Ci-Ce alkyl, C2-Ce alkenyl, and C2-Ce alkynyl; each R9is independently selected from halogen, -OH, -CN, -N02, -NH2, -NH(Ci-Cio alkyl), -N(Ci-Cio alkyl)2, C1-C10 alkyl, C1-C10 haloalkyl, -0(Ci-Cio alkyl), C2-Cio alkenyl, C2-Cio alkynyl, C3-Ci2cycloalkyl, and 3- to 12-membered heterocyclyl;R11is selected from hydrogen, halogen, -OH, -CN, -N02, -NH2, -NH(Ci-Cio alkyl), -N(Ci-Cio alkyl)2, -0(Ci-Cio alkyl), Ci-Ce alkyl, and Ci-Ce haloalkyl;R12is selected from hydrogen, halogen, -OH, -CN, -N02, -NH2, -NH(Ci-Cio alkyl), -N(Ci-Cio alkyl)2, -0(Ci-Cio alkyl), Ci-Ce alkyl, and Ci-Ce haloalkyl;R16is selected from hydrogen; Ci-Ce alkyl, and Cs-Ci2cycloalkyl, wherein the Ci-Ce alkyl, and C3-Ci2cycloalkyl are each optionally substituted with one or more substituents independently selected from halogen, -OH, -CN, -N02, -NH2, -NH(Ci-Cio alkyl), -N(Ci-Cio alkyl)2, -0(Ci-Cio alkyl), C2-Cio alkenyl, Ci-Ce alkyl, Ci-Ce haloalkyl, C2-Cio alkynyl, Cs-Ci2cycloalkyl, and 3- to 12- membered heterocyclyl;R20is independently selected at each occurrence from hydrogen; C1-6 alkyl, C2-6 alkenyl, C2. 6 alkynyl, C3-12 carbocycle, and 3- to 12-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -CN, -N02, -NH2, C1-C10 alkyl, C1-C10 haloalkyl, -0(Ci-Cio alkyl), C2-Cio alkenyl, C2-Cio alkynyl, Cs-Ci2cycloalkyl, and 3- to 12-membered heterocyclyl; andR21is independently selected at each occurrence from hydrogen; Ci-Ce alkyl, C2-Ce alkenyl, C2-Ce alkynyl, Cs-Ci2cycloalkyl, and 3- to 12-membered heterocyclyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -CN, -N02, -NH2, C1-C10 alkyl, C1-C10 haloalkyl, -0(Ci-Cio alkyl), C2-Cio alkenyl, C2-Cio alkynyl, Cs-Ci2cycloalkyl, and 3- to 12-membered heterocyclyl.

[0055] In certain embodiments, the CD38 inhibitor is a compound as disclosed in Scully et al., “Synthesis and Evaluation of Thiazoloquinolinones with Linkers to Eanble Targeting of CD38,”ACS Med. Chem. Let. (2017) 196-200, which is herein incorporated by reference in its entirety.For example, in certain embodiments, the CD38 inhibitor is a compound of formula (II):wherein R is cyclohexyl(Co-Ci alkyl), phenyl, or 4-piperdinyl, wherein each cyclohexyl and phenyl is substituted with one -(C0-C1 alkylene)-NH2.

[0056] In certain embodiments, the CD38 inhibitor is a compound as disclosed in Doyl et al., “A Covalent Binding Mode of a Pyrazole-based CD38 Inhibitor,” Helv. Chim. Acta (2023), 106(9), e202300080, which is herein incorporated by reference in its entirety. For example, in certain embodiments, the CD38 inhibitor is:4-(((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-1 -methyl-6-(1 H-pyrazol-4-yl)quinolin- 2(1 H)-one;8-(((1 r,4r)-4-hydroxy-4-methylcyclohexyl)amino)-2-(1 H-imidazol-1 -yl)-5-methylpyrido[3,2- d]pyrimidin-6(5H)-one; or2-(1 H-imidazol-1 -yl)-5-methyl-8-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrido[3, 2- d] pyri m id i n-6(5H )-o ne .

[0057] In certain embodiments, the CD38 inhibitor is a compound as disclosed in International Patent Publication No. WO 2023 / 084206, which is herein incorporated by reference in its entirety. For example, in certain embodiments, the CD38 inhibitor is a compound of formula (IH):or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein:Het is a 5-membered heteroaryl group comprising two heteroatoms independently selected from N and S, wherein the 5-membered heteroaryl group may optionally besubstituted with one or two substituents independently selected from C1-C3 alkyl, C1- C3 fluoroalkyl and C1-C3 hydroxyalkyl;X1is CH or N, and X2is CH or N, wherein at least one of X1and X2is N;L is a bond, CH2, CHMe, CMez or CO;R1is C1-C4 alkyl, C3-C6 cycloalkyl, hydroxyl, -O (C1-C4 alkyl), or -O(C3-Ce cycloalkyl), each of which may optionally be fluoro-substituted;R2is hydrogen, C1-C4 alkyl, C1-C4 fluoroalkyl, -CHO, -C(0)(Ci-C3 alkyl) or -C(0)(Ci-C3 fluoroalkyl);R3is hydrogen or methyl; orR2and R3, together with the nitrogen to which they are attached, form an azetidin-1-yl, pyrrolidin-1-yl or piperidin-1-yl group, each of which may optionally be fluorosubstituted.

[0058] In certain embodiments, the CD38 inhibitor is CCF642, CCF1118, or CCF1172 as disclosed in Vatolin et al., “Novel Protein Disulfide Isomerase Inhibitor

[0059] In certain embodiments, the CD38 inhibitor is a compound as disclosed in United States Patent Publication No. US 2017 / 0057910, which is herein incorporated by reference in its entirety. For example, in various embodiments embodiments, the CD38 inhibitor is(Z)-3-(4-methoxyphenyl)-5-((5-nitrothiophen-2-yl)methylene)thiazolidine-2, 4-dione (CCF642);N5,N6-bis(3-chlorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (CCF1118); or5-chloro-2-hydroxy-N-(naphthalen-1-yl)benzamide (CCF1172); the activities of which are disclosed in Vatolin et al., “Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma,” Cancer Res. (2016) 76(11), 3340-3350, which is also incorporated herein by reference in its entirety. For example, in various embodiments, the CD38 inhibitor is a compound of formula (IV):wherein Ar is an aryl or heteroaryl group, andR1-R4are independently selected from H, halogen, CF3, hydroxyl, C1-C4 alkyl, and C1-C4 oxyalkyl, or a pharmaceutically acceptable salt thereof.

[0060] In certain embodiments, the CD38 inhibitor is a compound as disclosed in United States Patent Publication No. US 2023 / 0331663, which is herein incorporated by reference in its entirety. For example, in certain embodiments, the CD38 inhibitor is a compound of formula (V):or a pharmaceutically acceptable salt thereof, whereinY is selected fromA is selected from C1-C5 alkylene wherein one or more of the methylene groups is optionally independently replaced with O, NH, CF3, or S, C1-C5 alkenylene, C1-C5 alkynylene, andB is selected from H, C1-C5 alkylene wherein one or more of the methylene groups is optionally independently replaced with O, NH, or S, C1-C5 alkenylene, C1-C5 alkynylene, andR1is selected from H, CF3, COOH, OH, NH2, halogen, O(Ci-C3 alkyl), NHSO2CH3, CH2OH, CH2COOH, NH(CI-C3alkyl), andR2is absent or is selected from OH, NH2, COOH, CN, O(Ci-C3 alkyl), halogen, NH(CI-C3 alkyl), andR3is absent or is selected from OH, NH2, COOH, CN, O(Ci-C3 alkyl), halogen, CF3, NH(CI-C3alkyl), andR4is selected from H, OH, NH2, COOH, halogen, OCH3, CH2OH, CH2COOH,CF3, (C1-C5 alkyl)NH2, NHSO2CH3, andR5is selected from H, CF3, COOH, OH, NH2, halogen, O(Ci-C3 alkyl), NHSO2CH3, CH2OH, CH2COOH, NH(CI-C3alkyl), andZ is selected from NH-C(O), N(CI-C5alkyl)-C(O), NH-CH2, N(CI-C5alkyl)-CH2, O-CH2, S-CH2, CH2-CH2, and CH=CH.

[0061] In certain embodiments, the CD38 inhibitor is a compound as disclosed in International Patent Publication No. WO 2023 / 288195, which is herein incorporated by reference in its entirety. For example, in certain embodiments, the CD38 inhibitor is a compound of formula (VI):or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein:X1is N or CH;X2is N or C(RX), wherein Rxis H, halogen, or Ci-Ce alkyl;X3is N or C(Ry), wherein Ryis H, -OH, Ci-Ce alkoxy, C3-C10 cycloalkyl, 3-10 membered heterocyclyl, or Ci-Ce alkyl, wherein the Ci-Ce alkoxy of Ryis optionally substituted with one or more Ci-Ce alkoxy, the C3-C10 cycloalkyl of Ryis optionally substituted with one or more halogen, Ci-Ce alkoxy, or -OH, the 3-10 membered heterocyclyl of Ryis optionally substituted with one or more Ci-Ce alkyl, and the Ci-Ce alkyl of Ryis optionally substituted with one or more halogen or -OH;X4is N or C(RZ), wherein Rzis H, halogen, -NH2, Ci-Ce alkoxy, or Ci-Ce alkyl; provided that at most two of X1, X2, X3, and X4are N; is optionally substituted with one or more -C(O)-NH2, or is optionally substituted with one or more Ci-Ce alkyl, orC4-C9 cycloalkyl, wherein the C4-C9 cycloalkyl is optionally substituted with one or more Ra, wherein each Rais independently -OH, halogen, Ci-Ce alkyl, Ci-Ce haloalkyl, Ci-Ce alkoxy, -C(O)Ci-C6 alkoxy, -NH(Ci-Ce haloalkyl), phenyl, phenoxy, or pyridinyl, wherein the Ci-Ce alkoxy of Rais optionally substituted with one or more halogen, phenyl, or Ci-Ce alkoxy, the Ci-Ce alkyl of Rais optionally substituted with one or more -OH or Ci-Ce alkoxy, the phenyl of Rais optionally substituted with one or more halogen or Ci-Ce alkoxy, andthe pyridinyl of Rais optionally substituted with one or more Ci-Ce haloalkyl, or4-9 membered heterocyclyl, wherein the 4-9 membered heterocyclyl is optionally substituted with one or more Rb, wherein each Rbis independently halogen, Ci-Ce alkyl, oxo, -C(O)(Ci-Ce alkyl), -C(O)(Ci-Ce alkoxy), or phenyl, wherein the phenyl of Rbis optionally substituted with one or more Ci-Ce haloalkyl, or phenyl, wherein the phenyl is optionally substituted with one or more halogen, or with Ci-Ce alkyl optionally substituted with -OH, or pyridinyl, wherein the pyridinyl is optionally substituted with one or more halogen, Ci-Ce haloalkyl, Ci-Ce alkoxy optionally substituted with one or more halogen, Ci-Ce alkyl optionally substituted with -OH, or -O-C3-C10 cycloalkyl optionally substituted with one or more halogen.

[0062] In certain embodiments, the CD38 inhibitor is a compound as disclosed in International Patent Publication No. WO 2024 / 102922, which is herein incorporated by reference in its entirety. For example, in certain embodiments, the CD38 inhibitor is a compound of formula (VII):or a pharmaceutically acceptable salt and / or a stereoisomer thereof, wherein:X is -C(O)NR4- or -S(O)2-NR4-;R1is 5-6 membered monocyclic heteroaryl or 8-10 membered bicyclic heteroaryl; wherein R1may optionally be substituted by one or more substituents each independently selected from R11;R2is selected from the group consisting of Ci-Ce alkoxy, Ci-Ce alkyl, halogen, hydroxyl, and hydrogen; wherein Ci-Ce alkoxy and Ci-Ce alkyl may optionally be substituted by one or more substituents each independently selected from R22;R3is selected from the group consisting of Ci-Ce alkyl, Ci-Ce alkoxy, 5-6 membered heteroaryl, 4-7 membered heterocyclyl, and halogen; wherein Ci-Ce alkyl, Ci-Cealkoxy, 5-6 membered heteroaryl, and 4-7 membered heterocyclyl may optionally be substituted by one or more substituents each independently selected from R33;R4is selected from the group consisting of hydrogen and Ci-Ce alkyl optionally substituted by one or more halogens;R5and R8are independently selected for each occurrence from the group consisting of hydrogen, deuterium, halogen, hydroxyl, Ci-Ce alkyl, Ci-Ce alkoxy, -CN, -NRaRb, -C(O)NRaRb, and -NR3-C(O)Rb;R6and R7are each independently selected from the group consisting of hydrogen and Ci-Ce alkyl optionally substituted by one or more halogens;R11, R22, and R33are independently selected for each occurrence from the group consisting of halogen, hydroxyl, Ci-Ce alkyl, Ci-Ce alkoxy, C3-C6 cycloalkyl, phenyl, -CN, -CF3, -NRaRb, -C(O)NRaRb, -NRa-C(O)Rb, and deuterium; wherein Ci-C6alkyl and Ci-Ce alkoxy may optionally be substituted by one or more substituents each independently selected from hydroxyl, halogen, and Ci-Ce alkoxy;Raand Rbare independently selected for each occurrence from the group consisting of hydrogen and C1-C3 alkyl, optionally substituted by one or more halogens; and m is 0, 1 , or 2.

[0063] In certain embodiments, the CD38 inhibitor is a compound as disclosed in International Patent Publication No. WO 2024 / 102924, which is herein incorporated by reference in its entirety. For example, in certain embodiments, the CD38 inhibitor is a compound of formula (VIII):or a pharmaceutically acceptable salt and / or a stereoisomer thereof, wherein:R1is 5-6 membered monocyclic heteroaryl or 8-10 membered bicyclic heteroaryl; wherein R1may optionally be substituted by one or more substituents each independently selected from R11;R2is selected from the group consisting of Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, and C3-C6 cycloalkyl; wherein R2may optionally be substituted by one or more substituents each independently selected from R22;R3is selected from the group consisting of 5-6 membered monocyclic heteroaryl, 8-10 membered bicyclic heteroaryl, 4-10 membered heterocyclyl, and phenyl; wherein R3may optionally be substituted by one or more substituents each independently selected from R33;R4is selected from the group consisting of hydrogen and Ci-Ce alkyl optionally substituted by one or more halogens;R5is selected from the group consisting of hydrogen, deuterium, halogen, hydroxyl, Ci- C6alkyl, Ci-C6alkoxy, -CN, -NRaRb, -C(O)NRaRb, and -NRa-C(O)Rb;R11, R22, and R33are independently selected for each occurrence from the group consisting of halogen, hydroxyl, Ci-Ce allyl, Ci-Ce alkoxy, C3-C6 cycloalkyl, phenyl, -CN, -CF3, -NRaRb, -C(O)NRaRb, -NRa-C(O)Rb, and deuterium; wherein Ci-C6alkyl and Ci-Ce alkoxy may optionally be substituted by one or more substituents each independently selected from hydroxyl and halogen: andRaand Rbare independently selected for each occurrence from the group consisting of hydrogen and C1-C3 alkyl optionally substituted by one or more halogens.

[0064] In certain embodiments, the CD38 inhibitor is a compound as disclosed in International Patent Publication No. WO 2024 / 102927, which is herein incorporated by reference in its entirety. For example, in certain embodiments, the CD38 inhibitor is a compound of formula (IX):or a pharmaceutically acceptable salt and / or a stereoisomer thereof, wherein:R1is 5-6 membered monocyclic heteroaryl or 8-10 membered bicyclic heteroaryl; wherein R1may optionally be substituted by one or more substituents each independently selected from R11;R2is selected from the group consisting of 5-6 membered heteroaryl, 4-7 membered heterocyclyl, and phenyl; wherein R2may optionally be substituted by one or more substituents each independently selected from R22;R3is selected from the group consisting of Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, and halogen; wherein Ci-Ce alkyl, C2-C6 alkenyl, and C2-C6 alkynyl may optionally be substituted by one or more halogens;R4is selected from the group consisting of hydrogen and Ci-Ce alkyl optionally substituted by one or more halogens;R5and R6are independently selected for each occurrence from the group consisting of hydrogen, halogen, deuterium, hydroxyl, Ci-Ce alkyl, Ci-Ce alkoxy, -CN, -NRaRb, -C(O)-NRaRb, and -NRa-C(O)-Rb; R11, R22, and R33are independently selected for each occurrence from the group consisting of halogen, hydroxyl, Ci-Ce allyl, Ci-Ce alkoxy, C3-C6cycloalkyl, phenyl, -CN, -CF3, -NRaRb, -C(O)-NRaRb, -NRa-C(O)-Rband deuterium; wherein Ci-Ce alkyl and Ci-Ce alkoxy may optionally be substituted by one or more substituents each independently selected from hydroxyl, halogen, and Ci-C3alkoxy; andRaand Rbare independently selected for each occurrence from the group consisting of hydrogen and Ci-C3alkyl optionally substituted by one or more halogens.

[0065] In certain embodiments, the CD38 inhibitor is a compound as disclosed in International Patent Publication No. WO 2016 / 087975, which is herein incorporated by reference in its entirety. For example, in certain embodiments, the CD38 inhibitor is a compound of formula (X):wherein Q is O, NH, N(H)C(O), or C(O)N(H);R1is -(C1-C5 alkyl)-SO2CH3, or Ci-Ce alkyl; wherein the C1-C5 alkyl or Ci-Ce alkyl can comprise straight-chain portions, branched chain portions, cycloalkyl portions, and wherein the Ci-Ce alkyl is optionally substituted by one OH or OCH3, and wherein said alkylene is optionally further substituted by 1 to 3 fluorine atoms; andR2is H, Ci-C3alkyl, or halogen.

[0066] In certain embodiments, the CD38 inhibitor is a quinoline or a quinazolin(on)e compound as disclosed in Haffner et al., “Discovery, Synthesis and Biological Evaluation of Thiazoloquin(azo)olin(on)es as Potent CD38 Inhibitors,” J. Med. Chem. (2015) 2548-3571 ; Becherer et al., “Discovery of 4-Aminoi-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38,” J. Med. Chem. (2015) 7021-7056; and Deaton et al., “2,4-Diamino-8-quiazoline carboxamides as novel, potent inhibitors of the NAD hydrolyzing enzyme CD38: Exploration of the 2-position structure-activity relationships,” Bioorg. Med. Chem. (2018) 2107-2150, each of which are herein incorporated by reference in their entirety.

[0067] In certain embodiments, the CD38 inhibitor is a compound as disclosed in International Patent Publication No. WO 2021 / 207186 and Blass, “Cyclic ADP Ribose Hydrolase (CD38) Inhibitors,” ACS Med. Chem. Lett. (2022) 13-14, both of which are herein incorporated by reference in their entirety. For example, in certain embodiments, the CD38 inhibitor is a compound of formula (XI):or a pharmaceutically acceptable salt thereof, wherein:X1and X2are independently CH or N, provided that X1and X2are not both CH;Cy is C3-C7 cycloalkyl optionally substituted with an oxo group or with one or two Rxgroups, wherein Rxis halo, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 hydroxyalkyl,-NHS(O)2CI-C4alkyl, or -S(O)2(Ci-C4alkyl);R1is -H, -NRaRb, halogen, -CN, -C(O)NH2, -COOH, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 hydroxyalkyl, C2-C4 alkenyl, C1-C4 alkoxy, C1-C4 alkoxyalkyl, C1-C4 alkylthio, C1-C4 alkylsulfonyl, C1-C4 alkoxy(alkylthio), C1-C4 haloalkylthio, C1-C4 haloalkoxy, C3-C4 cycloalkyl, or a 5-membered heteroaryl, wherein the 5-membered heteroaryl is optionally substituted with one, two or three C1-C4 alkyl groups;R2is a 5-membered heteroaryl optionally substituted with one, two or three deuterium or C1-C4 alkyl groups;Rdis H, C1-C4 haloalkyl, C1-C4 hydroxyalkyl, or C1-C4 alkyl optionally substituted with Ci- 04 alkoxy;Raand Rbindependently are H or C1-C4 alkyl; and n is 0 or 1 .

[0068] In certain embodiments, the CD38 inhibitor is a compound as disclosed in International Patent Publication No. WO 2021 / 087087 and Lagu et al., “Orally Bioavailable Enzymatic Inhibitor of CD38, MK-0159, Protects against Ischemia / Reperfusion Injury in the Murine Heart” J. Med. Chem. (2022) 9418-9446, both of which are herein incorporated by reference in their entirety. For example, in certain embodiments, the CD38 inhibitor is a compound of formula (XII):or a or a pharmaceutically acceptable salt thereof, wherein:A1and A2are independently CH or N, provided that A1and A2are not both N;X1is CR1Aand X2is NR5A, when bond a is a double bond and bond b is a single bond; orX1is NR1Band X2is CR5B, when bond a is a single bond and bond b is a double bond; andR1Ais H, C1-C4 alkyl, -NO2, -ON, -C(O)NRaRb, -CH2NRaRb, -(CHRc)mOH, C1-C4 haloalkyl, -CHO, -COORaor halogen;Ra, Rband Rcare each independently H or C1-C4 alkyl;R1Bis H or C1-C4 alkyl optionally substituted with 3-5 membered monocyclic heterocyclyl or hydroxy;R5Ais H or C1-C4 alkyl;R5Bis H, halogen, -CN, C1-C4 alkyl, C1-C4 haloalkyl, -NHRbor -C(O)NHRc;R2is 5-membered heteroaryl;R3is C1-C4 alkyl, C3-C6 cycloalkyl, bridged C7-C12 cycloalkyl, 5-6 membered monocyclic heterocyclyl optionally substituted with one or two oxo groups, or phenyl, wherein said alkyl, cycloalkyl, bridged cycloalkyl, heterocyclyl or phenyl is optionally substituted with one or two Rxgroups, wherein Rxis halogen, 3 to 6-membered heterocyclyl, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 hydroxyalkyl, S(0)2Me or ORd;Rdis H or C1-C4 alkyl optionally substituted with C1-C4 alkoxy;R4is H, halogen, -CN, C1-C4 alkyl, C1-C4 haloalkyl, -NHReor -C(O)NHRf;Reand Rfare each independently H or C1-C4 alkyl;R6is H or C1-C4 alkyl; n is 0 or 1 ; and m is 1 , 2 or 3, provided that, when R1Ais H or C1-C4 alkyl; and R2isN, then n is 1 ; and provided that when A1is N, X1is N and R1Bis C1-C4 alkyl, then n is 1.

[0069] In certain embodiments, the CD38 inhibitor is a compound as disclosed in International Patent Publication No. WO 2022 / 228496, which is herein incorporated by reference in its entirety. For example, in certain embodiments, the CD38 inhibitor is a compound of formula (XIII):wherein A1 is halogen; or 5 or 6 membered unsaturated monocyclic heterocycle containing 1 to 3 heteroatoms selected from the group consisting of N, O, and S, and optionally substituted with one or two Ci-Ce alkyl optionally substituted with 1, 2 or 3 halogen;optionally having one or two carbon atoms replaced with nitrogen; wherein A2 is optionally substituted with 0 or 1 -OH; -CN; halogen; Ci-Ce alkyl optionally substituted with 1, 2 or 3 halogen; C2-C6 alkynyl; Ci-Ce alkoxy; C3-C6 cycloalkoxy, in which the cycloalkyl optionally has one carbon atom replaced with O or S; -NR1R2, in which each of R1 and R2 independently is H, Ci-Ce alkyl, -C(O)(Ci-Ce alkyl);in whichis a 5- or 6-membered saturated or unsaturated heterocycle containing1 to 3 heteroatoms selected from the group consisting of N, O, and S, and optionally substituted 1-2 Ci-Ce alkyl, r-N£ >A3 selected from the group consisting of v^s ; Ci-Ce alkyl; -(CHR3)n-(C3-C8 cycloalkyl), in which the C3-C8 cycloalkyl optionally has one or two carbon atoms replaced with N, O, or S, n is 0, 1 , or 2, and R3is H or Ci-Ce alkyl; or,, in which the phenyl optionally has one or two carbon atoms replaced with N, k is 0, 1 or 2; wherein A3 is optionally substituted with 0, 1 , or 2 substituents independently selected from the group consisting of -OH; -CN; -OCH2CH2OCH3; -C(O)(Ci-C6 alkyl); halogen; Ci-Ce alkyl optionally substituted with 1-3 halogen, methoxy or hydroxy; Ci- Ce alkoxy optionally substituted with -NH2, dimethylamino, hydroxy or carboxy; C3-C6 cycloalkoxy; or C3-C8 cycloalkyl, in which the C3-C8 cycloalkyl optionally has one or two carbon atoms replaced with N, O, or S and is optionally substituted with 1-3 halogen, Ci-Ce alkyl, Ci-Ce alkyl or hydroxy;R is H or Ci-Ce alkyl; or a pharmaceutically acceptable salt, ester, stereoisomer, tautomer, solvate, prodrug, or combination thereof.

[0070] In certain embodiments, the CD38 inhibitor is a compound as disclosed in International Patent Publication No. WO 2023 / 098699, which is herein incorporated by reference in its entirety. For example, in certain embodiments, the CD38 inhibitor is a compound of formula (XIV):or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, whereinAi is Ci-Ce alkyl, phenyl, or 5- to 9-membered heteroaryl;of which is independently unsubstituted or substituted with one or two substituents selected from halogen, Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocyclyl, phenyl, heteroaryl, cyano, oxo, -NRaRt>, -C(O)R., -C(O)OR., -NO2, -OR., -S(O)2R., -CONRaRb, -NRaC(O)Rb, -NRaCO2Rb, or -NRaSO2Rb, wherein Raand Rb are each independently hydrogen or C1-C4 alkyl; preferably each of which is independently unsubstituted or substituted with oxo, -NH2, -C(O)CH3, or -CH3, wherein the left attaching position is attached to A1 and the right attaching position is attached to Li;Li and L2 are each independently a direct bond, -C(O) -, or -(CRcRd)n-, wherein Rcand Rd are each independently hydrogen, C1-C4 alkyl, hydroxy C1-C4 alkyl, or -C(O)OR„ wherein R, is hydroxy or C1-C4 alkyl, and n is a number of 1, 2, 3 or 4;R is H or Ci-Ce alkyl; andA3 is a phenyl ring, a 5- to 9-membered heteroaryl ring, a 5- to 9-membered heterocyclyl ring, a C3-C8 cycloalkyl ring, a C3-C8 cycloalkyl ring further fused with a phenyl ring orwith a 5- to 9-membered heteroaryl ring, or a bridged bicyclic cycloalkyl ring, each of said rings is independently unsubstituted or substituted with one or two or three substituents selected from halogen, Ci-Ce alkyl, or -ORf, wherein Rf is hydrogen, Ci- Ce alkyl, or heterocyclyl.

[0071] In certain embodiments, the CD38 inhibitor is a compound as disclosed in Li et al., “Discovery of a First-in-Class CD38 Inhibitor for the Treatment of Mitochondrial Myopathy,” J. Med. Chem. (2023) 12762-12775, which is herein incorporated by reference in its entirety. For example, in certain embodiments, the CD38 inhibitor is a compound of formulae (XVa), (XVb), or (XVc):

[0072] In certain embodiments, the CD38 inhibitor is a compound as disclosed in International Patent Publication No. WO 2022 / 077034, which is herein incorporated by reference in its entirety. For example, in certain embodiments, the CD38 inhibitor is a compound of formulae (XVIa) or (XVIb):(XVIa) (XVIb) or a pharmaceutically acceptable salt, ester, prodrug thereof wherein:-X-Y-Z- is =CR1-CR2=CR3-, =N-CR2=CR3-, =CR3-N=CR3- or =CR3-CR2=N if the compound is of formula (XVIa);-X-Y-Z- is CR1-CR2=C, N-CR2=C, or CR1-N=C if the compound is of formula (XVIb);R1is selected from the group consisting of H, halogen, -CN, Ci-Ce alkyl, Ci-Ce alkoxy, and Ci-Ce haloalkoxy; wherein Ci-Ce alkyl is optionally substituted with 1-3substituents independently selected from the group consisting of H, halogen, -CN, C1-C3 alkyl, -NH2, -(NH)-(CI-C3alkyl), -N(CI-C3alkyl)2, -CF3, -OCH3and -OCF3;R2is H, halogen, -CN, Ci-Ce alkyl, Ci-Ce alkoxy, Ci-Ce haloalkyl, Ci-Ce haloalkoxy, cycloalkyl, -O-cycloalkyl, heterocycloalkyl, -O-heterocycloalkyl, aryl, -O-aryl, -O-(C(R4)2)-R5, or -N(R6)2; wherein Ci-Ce alkyl, cycloalkyl, heterocycloalkyl, and aryl are each optionally substituted with 1-3 substituents independently selected from the group consisting of H, halogen, -CN, Ci-C3alkyl, -NH2, -(NH)-(CI-C3alkyl), -N(CI-C3alkyl)2, -CF3, -OCH3and -OCF3;R3is H, halogen, Ci-C3alkyl, -CF3, Ci-C3alkoxy, -OCF3or -N(R7)2; wherein R7is H or Ci-C3alkyl; n is an integer from 1 to 3; each R4is independently H or Ci-C3alkyl; wherein Ci-C3alkyl is optionally substituted with 1-3 substituents independently selected from the group consisting of H, halogen, -CN, Ci-C3alkyl, -NH2, -(NH)-(CI-C3alkyl), -N(CI-C3alkyl)2, -CF3, -OCH3and - OCF3;R5is selected from the group consisting of Ci-C3alkyl, Ci-C3haloalkyl, -(C2-C4alkyl)-OH, cycloalkyl, heterocycloalkyl, and aryl; wherein Ci-C3alkyl, cycloalkyl, heterocycloalkyl, and aryl are each optionally substituted with 1-3 substituents independently selected from the group consisting of H, halogen, -CN, Ci-C3alkyl, -NH2, -(NH)-(CI-C3alkyl), -N(CI-C3alkyl)2, -CF3, -OCH3and -OCF3;R6is independently H or Ci-C3alkyl; wherein Ci-C3alkyl is optionally substituted with 1- 3 substituents independently selected from the group consisting of H, halogen, -CN, Ci-C3alkyl, -NH2, -(NH)-(CI-C3alkyl), -N(CI-C3alkyl)2, -CF3, -OCH3and -OCF3;R8is H, -CH3or -CF3;each R9is independently selected from H, halogen, Ci-Ce alkyl, -CF3, Ci-Ce alkoxy, -0CF3, -CN, -N(R11)2, -C(O)OR12, -(NR11)-(CI-C3alkyl)-OR12, -(NR11)-C(O)R13, and -C(O)N(R11)2; each R10is independently selected from H, C1-C3 alkyl, -CF3, -OCH3, -OCF3, -CN, -N(R11)2, -C(O)OR12, -(NR11)-(CI-C3alkyl)-OR12, -(NR11)-C(O)R13, and - C(O)N(R11)2;R11is independently H or C1-C3 alkyl;R12is H or C1-C3 alkyl; andR13is C1-C3 alkyl.

[0073] In certain embodiments, the CD38 inhibitor is a compound as disclosed in International Patent Publication No. WO 2022 / 170265, which is herein incorporated by reference in its entirety. For example, in certain embodiments, the CD38 inhibitor is a compound of formula (XVIIa):(XVIIa) wherein X is O, or NR1, R1 is absent, H, ether, thioether, amine, ester, amide, halogen, or substituted or unsubstituted alkyl, heteroalkyl, alkenyl, alkynyl;R2is a substituted or unsubstituted alkyl, cycloalkyl, heteroalkyl, heterocycloalkyl, heteroaryl, aryl, alkylaryl, ether, thioether, amine, ester, amide, halogen, or oxo;Rs is H, substituted or unsubstituted alkyl, alkoxy, cycloalkyl, heterocycloalkyl; or a glycoside;R4 is a H, oxo, -NR10R11; wherein R10 and Rn are each independently H, substituted or unsubstituted alkyl, aryl, cycloalkyl, or alkylaryl; andRs-Rs are each independently H, -OH, halogen, amide, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkylaryl, or substituted or unsubstituted heteroaryl.

[0074] For example, in certain embodiments, the CD38 inhibitor is a compound of formula (XVIIb):(XVIIb) wherein Y and Z are independently O or S;A and E are independently O or S;R12 and R19 are independently substituted or unsubstituted H, alkyl, alkenyl, aryl or alkylaryl;R13-R18 are independently hydrogen, -OH, -SH, ether, thioether, amine, ester, carboxylic acid, amide, sulfonyl, phosphate, nitro, halogen, nitrile, trifluoromethyl, or substituted or unsubstituted alkyl, heteroalkyl, alkenyl, alkynyl; wherein substituents for the substituted groups are independently halogen, hydroxyl, thiol, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, alkoxy, cyano, carbonyl, amino, amido, sulfonyl, sulfonic acid, phosphoryl, or phosphonyl; and pharmaceutically acceptable salts thereof.

[0075] For example, in certain embodiments, the CD38 inhibitor is a compound of formula (XVIIc):wherein M is O or C;R22 and R23 are independently H, -OH, or halogen;R28 is -OH, nucleotide derivative,; whereinR20 is O, NH, or NH2;R21 is H, halogen, substituted or unsubstituted alkyl, aryl, cycloalkyl, alkylaryl, or heteroaryl; andR30 is absent, H, substituted or unsubstituted aklyl, aryl, cycloalkyl, alkylaryl, or heteroaryl; andR29 is -OH, substituted or unsubstituted alkyl, aryl, cycloalkyl, alkylaryl, or heteroaryl; or an enzyme,whereinR24-R27 are independently hydrogen, -OH, -SH, ether, thioether, amine, ester, carboxylic acid, amide, sulfonyl, phosphate, nitro, halogen, nitrile, trifluoromethyl, or substituted or unsubstitued alkyl, heteroalkyl, alkenyl, or alkynyl.

[0076] For example, in certain embodiments, the CD38 inhibitor is a compound of formulae (XVIId):(XVI Id) wherein M is O or C;R20 is O, NH, or NH2;R21 is H, halogen, substituted or unsubstituted alkyl, aryl, cycloalkyl, alkylaryl, or heteroaryl; andR22 and R23 are independently H, -OH, or halogen.

[0077] In certain embodiments of formulae (XVIIc) and (XVIId) as described herein, the CD38 inhibitor is:

[0078] In certain embodiments, the CD38 inhibitor is a compound as disclosed in International Patent Publication No. WO 2021 / 021986, which is herein incorporated by reference in its entirety. For example, in certain embodiments, the CD38 inhibitor is a compound of formula (XVIII):(XVIII) or a pharmaceutically acceptable salt thereof, wherein:V is N or CRV, wherein Rvis H, halogen, or C1-C4 alkyl;W is N or CRW, wherein Rwis H, halogen, or C1-C4 alkyl; the moiety represented by:Ring A is a 5-membered heteroaryl group having 1, 2, or 3 ring-forming heteroatoms selected from N, O, and S, wherein the 5-membered heteroaryl group of Ring A is optionally substituted by 1 , 2, or 3 substituents independently selected from halo and C1-C4 alkyl; each RNis independently selected from H, C1-C4 alkyl, Ce-Cio aryl, C3-C7 cycloalkyl, 5-10 membered heteroaryl, or 4-10 membered heterocycloalkyl, wherein said C1-C4 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, Ci-Ce haloalkyl, Ce-Cio aryl, C3-C7 cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl of RNare each optionally substituted with 1 , 2, 3, 4, or 5 substituents independently selected from Cy, Cy(Ci-C4 alkyl), halogen, Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, Ci-Ce haloalkyl, CN, NO2, ORa, SRa, C(O)Rb, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb,OC(O)NRcRd, C(=NRe)NRcRd, NRcC(=NRe)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)ORa, NRcC(O)NRcRd, NRcS(O)Rb, NRcS(0)2Rb, NRcS(0)2NRcRd, S(O)Rb, S(O)NRcRd, S(0)2Rb, and S(O)2NRcRd; each RA, RB, and Rcis independently selected from H, halogen, C1-C4 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, Ci-Ce haloalkyl, Ce-Cio aryl, C3-C7 cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl, wherein said C1-C4 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, Ci-Ce haloalkyl, Ce-Cio aryl, C3-C7 cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl of RA, RB, and Rcare each optionally substituted with 1 , 2, 3, 4, or 5 substituents independently selected from Cy, Cy(Ci-C4 alkyl), halogen, Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, Ci-Ce haloalkyl, CN, NO2, ORa, SRa, C(O)Rb, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, C(=NRe)NRcRd, NRcC(=NRe)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)ORa, NRcC(O)NRcRd, NRcS(O)Rb, NRcS(O)2Rb, NRcS(O)2NRcRd, S(O)Rb, S(O)NRcRd, S(O)2Rb, and S(O)2NRcRd;L is a C1-C4 alkylene linker; n is 0 or 1 ;Q is H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C10 haloalkyl, Ce-Cio aryl, C3-C14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein said C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C10 haloalkyl, Ce-Cio aryl, C3-C14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of Q are each optionally substituted with 1 , 2, 3, 4, or 5 substituents independently selected from Cy1, Cy1(Ci-C4 alkyl), halogen, Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, Ci-Ce haloalkyl, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, C(=NRe1)NRc1Rd1, NRc1C(=NRe1)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)ORa1, NRc1C(O)NRc1Rd1, NRc1S(O)Rb1, NRc1S(O)2Rb1, NRc1S(O)2NRc1Rd1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, and S(O)2NRc1Rd1; wherein Q is other than H when n is 0; each Cy is independently selected from Ce-Cio aryl, C3-C7 cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl, each optionally substituted by 1, 2, 3, or 4 substituents independently selected from halogen, Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, Ci-Ce haloalkyl, Ce-Cio aryl(Ci-C4alkyl), C3-C7 cycloalkyl(Ci-C4alkyl), 5-10 membered heteroaryl (C1-C4 alkyl), 4-10 membered heterocycloal kyl(Ci-C4alkyl), CN, N02, OR3, SR3, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, C(=NRe)NRcRd, NRcC(=NRe)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)ORa, NRcC(O)NRcRd, NRcS(O)Rb, NRcS(0)2Rb, NRcS(0)2NRcRd, S(O)Rb, S(O)NRcRd, S(0)2Rb, and S(O)2NRcRd; each Cy1is independently selected from Ce-Cio aryl, C3-C7 cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl, each optionally substituted by 1 , 2, 3, or 4 substituents independently selected from halogen, Ci-Ce alkyl, C2-Ce alkenyl, C2-Ce alkynyl, Ci-Ce haloalkyl, Ce-Cio aryl, C3-C7 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, Ce-Cio aryl(Ci-C4 alkyl), C3-C7 cycloalkyl(Ci-C4 alkyl), 5-10 membered heteroaryl(Ci-C4 alkyl), 4-10 memberedS(O)2NRc2Rd2; each Ra, Rb, Rc, Rd, Ra1, Rb2, Rc1, Rd1, R32, Rb2, Rc2, and Rd2is independently selected from H, Ci-Ce alkyl, Ci-Ce haloalkyl, C2-Ce alkenyl, C2-Ce alkynyl, Ce-Cio aryl, C3-C7 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, Ce-Cio aryl(Ci-C4 alkyl), C3-C7 cycloal kyl(Ci-C4 alkyl), 5-10 membered heteroaryl (C1-C4 alkyl), and 4-10 membered heterocycloal kyl(Ci-C4 alkyl), wherein said Ci-Ce alkyl, C2-Ce alkenyl, C2-Ce alkynyl, Ce-Cio aryl, C3-C7 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, Ce-Cio aryl(Ci-C4 alkyl), C3-C7 cycloalkyl(Ci-C4 alkyl), 5-10 membered heteroaryl(Ci-C4 alkyl), and 4-10 membered heterocycloal kyl(Ci-C4alkyl) of Ra, Rb, Rc, Rd, Ra1, Rb1, Rc1, Rd1, R32, Rb2, Rc2, and Rd2is optionally substituted with 1 , 2, 3, 4, or 5 substituents independently selected from Cy2, Cy2(Ci-C4 alkyl), halogen, C1-C4 alkyl, C1-C4 haloalkyl, Ci-Ce haloalkyl, C2- C6alkenyl, C2-C6alkynyl, CN, OR33, SR33, C(O)Rb3, C(O)NRc3Rd3, C(O)ORa3,or Rcand Rdtogether with the N atom to which they are attached form a 4-7 membered heterocycloalkyl group optionally substituted with 1 , 2, or 3 substituents independently selected from halogen, C1-C4 alkyl, C1-C4 haloalkyl, CN, ORa3, SRa3,or Rc1and Rd1together with the N atom to which they are attached form a 4-7 membered heterocycloalkyl group optionally substituted with 1 , 2, or 3 substituents independently selected from halogen, C1-C4 alkyl, C1-C4 haloalkyl, CN, ORa3, SRa3, C(O)Rb3,or Rc2and Rd2together with the N atom to which they are attached form a 4-7 membered heterocycloalkyl group optionally substituted with 1 , 2, or 3 substituents independently selected from halogen, C1-C4 alkyl, C1-C4 haloalkyl, CN, ORa3, SRa3, C(O)Rb3,each Cy2is Ce-Cio aryl, C3-C7 cycloalkyl, 5-10 membered heteroaryl, or 4-10 membered heterocycloalkyl, each optionally substituted by 1 , 2, 3, or 4 substituents independently selected from halogen, C1-C4 alkyl, C1-C4 haloalkyl, Ci-Ce haloalkyl, C2-Ce alkenyl, C2- C6alkynyl, CN, ORa3, SRa3, C(O)Rb3, C(O)NRc3Rd3, C(O)ORa3, OC(O)Rb3, OC(O)NRc3Rd3, NR^R^, NRc3C(O)Rb3, NRc3C(O)NRc3Rd3, NRc3C(O)ORa3, C(=NRe3)NRc3Rd3, NRc3C(=NRe3)NRc3Rd3, S(O)Rb3, S(O)NRc3Rd3, S(O)2Rb3, NR^SCO^Rh3, NR^SCO^NR^R113, and S(O)2NRc3Rd3; each Ra3, Rb3, Rc3, and Rd3is independently selected from H, Ci-Ce alkyl, Ci-Ce haloalkyl, C2-Ce alkenyl, C2-Ce alkynyl, Ce-Cio aryl, C3-C7 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, Ce-Cio aryl(Ci-C4 alkyl), C3-C7 cycloal kyl(Ci-C4 alkyl), 5-10 membered heteroaryl(Ci-C4 alkyl), and 4-10 membered heterocycloal kyl(Ci-C4 alkyl), wherein said Ci-Ce alkyl, Ci-Ce haloalkyl, C2-Ce alkenyl, C2-Ce alkynyl, Ce-Cio aryl, C3-C7 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, Ce-Cio aryl(Ci-C4 alkyl), C3-C7 cycloal kyl(Ci-C4 alkyl), 5- 10 membered heteroaryl(Ci-C4 alkyl), and 4-10 membered heterocycloal kyl(Ci-C4 alkyl) are each optionally substituted with 1 , 2, or 3 substituents independentlyselected from OH, CN, amino, halogen, Ci-Ce alkyl, Ci-Ce alkylamino, di(Ci-C6)amino, Ci-Ce alkoxy, Ci-Ce haloalkyl, and Ci-Ce haloalkoxy; each Re, Re1, Re2, and Re3is independently selected from H, C1-C4 alkyl, and CN; wherein one or more ring-forming C or N atoms of any aforementioned heterocycloalkyl group is optionally substituted by an oxo (=0) group; wherein one or more ring-forming S atoms of any aforementioned heterocycloalkyl group is optionally substituted by one or two oxo (=0) groups; and with the proviso that when:V is CH;W is CH; the moiety represented by:n is 0; andQ is cyclohexyl optionally substituted with 1 , 2, 3, 4, or 5 substituents independently selected from Cy1, Cy1(Ci-C4 alkyl), halogen, Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, Ci-C6haloalkyl, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, C(=NRe1)NRc1Rd1, NRc1C(=NRe1)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)ORa1, NRc1C(O)NRc1Rd1, NRc1S(O)Rb1, NRc1S(O)2Rb1, NRc1S(O)2NRc1Rd1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, and S(O)2NRc1Rd1; then Ring A is other than

[0079] In certain embodiments, the CD38 inhibitor is a compound as disclosed in UnitedStates Patent Publication No. US 2022 / 0242862, which is herein incorporated by reference in itsentirety. For example, in certain embodiments, the CD38 inhibitor is a compound of formula (XIX):or a pharmaceutically acceptable salt thereof, wherein:X3is CR3or N;X4is CR4or N;A is a 5-membered heteroaryl group having 1 , 2 or 3 ring-forming heteroatoms selected from N, O, and S, wherein the 5-membered heteroaryl group of A is optionally substituted by 1, 2, or 3 substituents independently selected from halo and Ci- 04 alkyl;L is a C1-C4 alkylene linker; n is 0 or 1 ;Q is H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C10 haloalkyl, Ce-Cio aryl, C3- C14 cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl, wherein said C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C10 haloalkyl, Ce- C10 aryl, C3-C14 cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl of Q are each optionally substituted with 1 , 2, 3, 4, or 5 substituents independently selected from Cy1, Cy1(Ci-C4 alkyl), halogen, Ci-Ce alkyl, C2- C6alkenyl, C2-C6alkynyl, Ci-C6haloalkyl, CN, NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, C(=NRe)NRcRd, NRcC(=NRe)NRcRd, NRcRd, NRc(O)Rb, NRc(O)ORa, NRc(O)NRcRd, NRcS(O)Rb, NRcS(O)2Rb, NRcS(O)2NRcRd, S(O)Rb, S(O)NRcRd, S(O)2Rb, and S(O)2NRcRd, wherein said Ci-C6alkyl, C2-C6alkenyl, and C2-C6 alkynyl are optionally substituted by 1, 2, or 3 substituents independently selected from Cy1, CN, NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, C(=NRe)NRcRd, NRcC(=NRe)NRcRd, NRcRd, NRc(O)Rb, NRc(O)ORa, NRcC(O)NRcRd, NRc(O)Rb, NRcS(O)2Rb, NRcS(O)2NRcRd, S(O)Rb, S(O)NRcRd, S(O)2Rb, and S(O)2NRcRd;each Cy1is independently selected from Ce-Cio aryl, C3-C7 cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl, each optionally substituted by 1 , 2, 3, or 4 substituents independently selected from halogen, Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, Ci-Ce haloalkyl, Ce-io aryl(Ci-C4 alkyl), C3-C7 cycloalkyl(Ci-C4 alkyl), 5- 10 membered heteroaryl (C1-C4 alkyl), 4-10 membered heterocycloal kyl(Ci-C4 alkyl), CN, NO2, OR31, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, C(=NRe1)NRc1Rd1, NRc1C(=NRe1)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)Ra1, NRc1C(O)NRc1Rd1, NRc1S(O)2Rb1, NRc1S(O)2Rb1, NRc1S(O)2NRc1Rd1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, and S(O)2NRc1Rd1;R1is Ci-Ce alkyl;R2, R3, and R4are each independently selected from H, halogen, Ci-Ce alkyl, C2- Ce alkenyl, C2-C6 alkynyl, Ci-Ce haloalkyl, Ce-io aryl, C3-C7 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-io aryl(Ci-C4alkyl), C3-C7 cycloalkyl(Ci-C4 alkyl), 5-10 membered heteroaryl(Ci-C4 alkyl), 4-10 membered heterocycloalkyl(Ci-C4alkyl), CN, NO2, ORa2, SR32, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, NRc2Rd2, NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)ORa2, NRc2C(O)NRc2Rd2, C(=NRe2)Rb2, C(=NRe2)NRc2Rd2, NRc2C(=NRe2)NRc2Rd2, NRc2S(O)Rb2, NRc2S(O)2Rb2, NRc2S(O)2NRc2Rd2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2, and S(O)2NRc2Rd2, wherein said Ci-C6alkyl, C2-C6alkenyl, C2-C6 alkynyl, Ci-Ce haloalkyl, Ce-io aryl(Ci-C4 alkyl), C3-C7 cycloalkyl(Ci-C4 alkyl), 5- 10 membered heteroaryl (C1-C4 alkyl), 4-10 membered heterocycloalkyl(Ci-C4 alkyl) of R2, R3, and R4are each optionally substituted with 1 , 2, 3, 4, or 5 substituents independently selected from halogen, Ci-Ce alkyl, C2-C6 alkenyl, C2-C6 alkynyl, Ci-each Ra, Rb, Rc, Rd, Ra1, Rb1, Rc1, Rd1, R32, Rb2, Rc2, and Rd2is independently selected from H, Ci-Ce alkyl, Ci-Ce haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, Ce-io aryl, C3-C7 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, Ce- io aryl(Ci-C4alkyl), C3-C7 cycloalkyl(Ci-C4alkyl), 5-10 membered heteroaryl(Ci- C4 alkyl), 4-10 membered heterocycloalkyl(Ci-C4 alkyl), wherein said Ci-Ce alkyl, C2- Ce alkenyl, C2-C6 alkynyl, Ce-io aryl, C3-C7 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, Ce-io aryl(Ci-C4 alkyl), C3-C7 cycloalkyl(Ci-C4 alkyl), 5-10 membered heteroaryl(Ci-C4 alkyl), 4-10 membered heterocycloalkyl(Ci- C4alkyl) of Ra, Rb, Rc, Rd, Ra1, Rb1, Rc1, Rd1, Ra2, Rb2, Rc2, and Rd2is optionally substituted with 1 , 2, 3, 4, or 5 substituents independently selected from halogen, Ci- 04 alkyl, C1-C4 haloalkyl, Ci-Ce haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, CN, ORa3,or Rcand Rdtogether with the N atom to which they are attached form a 4-7 membered heterocycloalkyl group optionally substituted with 1 , 2, or 3 substituents independently selected from halogen, C1-C4 alkyl, C1-C4 haloalkyl, CN, ORa3, SRa3,or Rc1and Rd1together with the N atom to which they are attached form a 4-7 membered heterocycloalkyl group optionally substituted with 1 , 2, or 3 substituents independently selected from halogen, C1-C4 alkyl, C1-C4 haloalkyl, CN, ORa3, SRa3,or Rc2and Rd2together with the N atom to which they are attached form a 4-7 membered heterocycloalkyl group optionally substituted with 1 , 2, or 3 substituents independently selected from halogen, C1-C4 alkyl, C1-C4 haloalkyl, CN, ORa3, SRa3,each Ra3, Rb3, Rc3, and Rd3is independently selected from H, Ci-Ce alkyl, Ci-Ce haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, Ce-Cio aryl, C3-C7 cycloalkyl, 5-6 membered heteroaryl, and 4-7 membered heterocycloalkyl, wherein said Ci-Ce alkyl, Ci-Ce haloalkyl, C2-C6alkenyl, C2-C6 alkynyl, Ce-Cio aryl, C3-C7 cycloalkyl, 5-6 membered heteroaryl, and 4- 7 membered heterocycloalkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halogen, Ci-Ce alkyl, Ci- Ce alkoxy, Ci-Ce haloalkyl, and Ci-Ce haloalkoxy; and each Re, Re1, Re2, and Re3is independently selected from H, C1-C4 alkyl, and CN; wherein when X3is CR3and X4is CR4, then Ring A is not

[0080] In certain embodiments, the CD38 inhibitor is a compound as disclosed in International Patent Publication No. WO 2014 / 180544, which is herein incorporated by reference in its entirety. For example, in certain embodiments, the CD38 inhibitor is a compound of formula (XX):R2 and R3 represent independently from each other H, halogen, cyano, C1-C4 alkyl, acetyl, C1-C4 haloalkyl, C1-C4 alkyloxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsufonyl, -COOH, -(C1-C4 alkyl)-COOH, -NR4R5, wherein R4 and R5 are independently from each other H or C1-C4 alkyl; or -CO-NRxRy, whereinRx represents C3-C6 cycloalkyl or C1-C2 alkyl substituted with morpholinyl, and Ry represents H, orRx and Ry form together with the nitrogen attached a 5 or 6 membered heterocyclic ring optionally containing one further heteroatom selected from O and N and optionally substituted with one or more substituents selected from the group consisting of C1-C2 alkyl and -COO-(Ci-C4 alkyl); orR represents Ci-Ce alkyl optionally substituted with one or more substituents selected from the group consisting of -OH, -COOH, -COO-(Ci-C4 alkyl), -NH-CO-CF3, -CF3, Ci-Ce cycloalkyl optionally substituted by -OH or -CH2-OH, and a 5- or 6-membered heterocyclic ring containing one or two heteroatom selected from O, N, and S, with the proviso that R is different from methyl; or R represents C1-C4 cycloalkyl optionally substituted with one or more substituents selected from the group consisting of OH and halogen; orR represents phenyl C1-C2 alkyl), optionally substituted by one or more C1-C4 alkoxy; adamantyl, or pyridyl, with the proviso that R is different from phenyl-ethyl-; or a pharmaceutically acceptable salt or stereoisomer thereof or a pharmaceutically acceptable salt of the stereoisomer.

[0081] In certain embodiments, the CD38 inhibitor is a compound as disclosed in UnitedStates Patent Publication No. US 2014 / 0221319, which is herein incorporated by reference in its entirety. For example, in certain embodiments, the CD38 inhibitor is a compound of formulae (XXIa) to (XXIo):(XXId) (XXIe) (XXIf)wherein ring A is an aryl heterocycle diradical; ring B is heteroaryl; ring C is a 5-membered, unsaturated heterocycle diradical; ring D is aryl or heteroaryl; ring E is a 5-membered heterocycle radical;X is halogen;R is H, halogen, aryl, nitro, alkyl, hydroxy, alkoxy, or amino;R1is hydroxy, alkoxy, or amino;R2is hydroxy, alkoxy, or amino;R3is H, cyano, -CO2R4, or -C(O)N(R4)2;R4is H or alkyl;Y is -O- or -NH-;Y1is -O-, -S-, -NH-; andY2is =N- or =CR-

[0082] In certain embodiments, the CD38 inhibitor is a compound as disclosed in Kellenberger et al., “Flavonoids as inhibitors of human CD38,” Bioorg. Med. Chem. Lett. (2011) 3939-3942, which is herein incorporated by reference in its entirety. For example, in certain embodiments, the CD38 inhibitor is luteolinidin, kuromanin, delphinidin, pelargonidin, malvidin, quercetagetinidin, peonidin, cyanidin, diosmetinidin, petunidin, fisetinidin, luteolin, myricetin, quercetin, robinetin, or quercetagetin.

[0083] In certain embodiments, the CD38 inhibitor is:6-(1H-lmidazol-1-yl)-4-methyl-N-(1-(methylsulfonyl)piperidin-4-yl)picolinamide;N-(1 -(Ethylsulfonyl)piperidin-4-yl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;N-(1-(cyclopropylsulfonyl)piperidin-4-yl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;6-(1H-lmidazol-1-yl)-N-(1-( (2-methoxyethyl)sulfonyl)piperidin-4-yl)-4- methylpicolinamide;N-(1-(Cyclohexylsulfonyl)piperidin-4-yl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(1-(propylsulfonyl)piperidin-4-yl)picolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(1-(methylsulfonyl)azetidin-3-yl)picolinamide;N-(4,4-Difluorocyclohexyl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(tetrahydro-2H-pyran-3-yl)picolinamide;N-(1-Acetylpiperidin-4-yl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(piperidin-4-yl)picolinamide;N-Cyclobutyl-6-(1H-imidazol-1-yl)-4-methylpicolinamide;N-(1-Butyrylpiperidin-4-yl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(1-(N-methylsulfamoyl)piperidin-4-yl)picolinamide;6-(1H-lmidazol-1-yl)-4-methoxy-N-(1-(methylsulfonyl)piperidin-4-yl)picolinamide;6-(1H-lmidazol-1-yl)-N-(1-(methylsulfonyl)piperidin-4-yl)picolinamide;N-(1-(N,N-Dimethylsulfam oyl)piperidin-4-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(1-(2-morpholinoacetyl)piperidin-4-yl)picolinamide;6-(1H-lmidazol-1-yl)-N-(1-(3-methoxypropanoyl)piperidin-4-yl)-4-methylpicolinamide;N-(1-(Dimethylcarbamoyl)piperidin-4-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(1-(methylcarbamoyl)piperidin-4-yl)picolinamide;N-(1,1-Dioxidotetrahydrothiophen-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;N-(2,2-Dimethyltetrahydro-2H-pyran-4-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;N-(4,4-Difluorotetrahydro-2H-pyran-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;N-(5,5-Difluorotetrahydro-2H-pyran-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;N-(3,3-Dimethyltetrahydro-2H-pyran-4-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;N-(8-Oxabicyclo[3.2.1]octan-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;N-(6,6-Dimethyltetrahydro-2H-pyran-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(2-methyltetrahydro-2H-pyran-4-yl)picolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(tetrahydro-2H-pyran-4-yl)picolinamide;N-Cycloheptyl-6-(1H-imidazol-1-yl)-4-methylpicolinamide;N-(3,3-Difluorocyclopentyl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;N-(1,1-Dioxidotetrahydro-2H-thiopyran-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;(S)-6-(1H-lmidazol-1-yl)-4-methyl-N-( tetrahydrofuran-3-yl)picolinamide;(S)-6-(1H-lmidazol-1-yl)-4-methyl-N-(pyrrolidin-3-yl)picolinamide hydrochloride;(R)-6-(1H-lmidazol-1-yl)-4-methyl-N-(tetrahydrofuran-3-yl)picolinamide; tert-Butyl (R)-3-( 6-(1 H-imidazol-1-yl)-4-methylpicolinamido)pyrrolidine-1 -carboxylate;(R)-6-(1H-lmidazol-1-yl)-4-m ethyl-N-(tetrahydro-2H-pyran-3-yl)picolinamide;(S)-6-(1H-lmidazol-1-yl)-4-m ethyl-N-(tetrahydro-2H-pyran-3-yl)picolinamide; tert-Butyl (S)-3-( 6-(1 H-imidazol-1 -yl)-4-methylpicolinamido)piperidine-1 -carboxylate;(S)-6-(1H-lmidazol-1-yl)-4-methyl-N-(piperidin-3-yl)picolinamide dihydrochloride; tert-Butyl (R)-3-(6-(1H-imidazol-1-yl)-4-methylpicolinamido)piperidine-1 -carboxylate;(S)-6-(1H-lmidazol-1-yl)-4-methyl-N-(1-(methylsulfonyl)piperidin-3-yl)picolinamide;(R)-6-(1H-lmidazol-1-yl)-4-methyl-N-(piperidin-3-yl)picolinamide dihydrochloride;(R)-6-(1H-lmidazol-1-yl)-4-methyl-N-(pyrrolidin-3-yl)picolinamide dihydrochloride;(R)-6-(1H-lmidazol-1-yl)-4-methyl-N-(1-( methylsulfonyl)pyrrolidin-3-yl)picolinamide;(R)-6-(1H-lmidazol-1-yl)-4-methyl-N-(1-( methylsulfonyl)piperidin-3-yl)picolinamide;(S)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;(R)-6-(1H-lmidazol-1-yl)-4-m ethyl-N-( 1-m ethyl-2-oxopiperidin-3-yl)picolinamide;(R)-N-(1 , 1 -Dioxidotetrahydro-2H-thiopyran-3-yl)-6-(1 H-imidazol-1 -yl)-4- methylpicolinamide;(R)-6-(1H-lmidazol-1-yl)-4-methyl-N-(2-oxopiperidin-3-yl)picolinamide;(R)-6-(1H-lmidazol-1-yl)-4-methyl-N-(1-methylpiperidin-3-yl)picolinamide;(S)-6-(1H-lmidazol-1-yl)-4-methyl-N-(2-oxopiperidin-3-yl)picolinamide;2-(1H-lmidazol-1-yl)-6-methyl-N-(1-(methylsulfonyl)piperidin-4-yl)pyrimidine-4- arboxamide;(R)-6-(1 H-imidazol-1 -yl)-N-( tetrahydro-2H-pyran-3-yl)-4-(trifluoromethyl)picolinamide;(R)-N-(2,6-Dioxopiperidin-3-yl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;(R)-N-(6,6-Dimethyltetrahydro-2H-pyran-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;(R)-N-(5,5-Difluorotetrahydro-2H-pyran-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;(R)-N-(5,5-Difluorotetrahydro-2H-pyran-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;(R)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(1 H-imidazol-1 -yl)-6- methyl pyri midi ne-4- carboxamide;(R)-2-(1 H-lmidazol-1-yl)-6-m ethyl-N-( tetrahydro-2H-pyran-3-yl)pyrimidine-4- carboxamide;(S)-N-(4,4-Difluorotetrahydro-2H-pyran-3-yl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;(R)-N-(4,4-Difluorotetrahydro-2H-pyran-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(1-( ( tetrahydrofuran-3-yl)sulfonyl)piperidin-4- yl)picolinamide;2-(1H-lmidazol-1-yl)-N-(1-(methylsulfonyl)piperidin-4-yl)pyrimidine-4-carboxamide;(R)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(1 H-imidazol-1 -yl)pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(1-(methylsulfonyl)piperidin-4-yl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;(R)-2-(1H-lmidazol-1-yl)-N-(tetrahydro-2H-pyran-3-yl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;(R)-N-(1 , 1 -Dioxidotetrahydrothiophen-3-yl)-2-(1 H-imidazol-1 -y I )-6-(trifl uoro methyl )pyri m id i ne-4-carboxa m ide ;(R)-N-(1 , 1 -Dioxidotetrahydrothiophen-3-yl)-6-(1 H-imidazol-1 -y I )-4- (trifluoromethyl)picolinamide;6-(1H-lmidazol-1-yl)-3-methyl-N-(1-(methylsulfonyl)piperidin-4-yl)picolinamide;(R)-2-(1H-lmidazol-1-yl)-N-(tetrahydro-2H-pyran-3-yl)pyrimidine-4-carboxamide;(R)-6-(1 H-lmidazol-1-yl)-3-m ethyl-N-( tetrahydro-2H-pyran-3-yl)picolinamide;6-(1H-lmidazol-1-yl)-N-(1-(methylsulfonyl)piperidin-4-yl)-4-(trifluoromethyl)picolinamide;(R)-6-(1H-lmidazol-1-yl)-4-methyl-N-(1-(oxetan-3-yl)piperidin-3-yl)picolinamide;(S)-N-(1,1-Dioxidotetrahydro-2H-thiopyran-3-yl)-6-(1H-imidazol-1-yl)-4- methylpicolinamide;(S)-6-(1H-lmidazol-1-yl)-4-methyl-N-(1-methyl-2-oxopiperidin-3-yl)picolinamide;(R)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(1-(oxetan-3-ylsulfonyl)piperidin-4-yl)picolinamide;4-(((1 r,4r)-4-hydroxycyclohexyl)amino)-1 -methyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;4-(((1 r,4r)-4-aminocyclohexyl)amino)-1 -methyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;4-(((1s,4s)-4-aminocyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one;4-(((1 S,2S)-2-aminocyclohexyl)amino)-1 -methyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;4-(((1 R,2R)-2-aminocyclohexyl)amino)-1 -methyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;4-((3-aminocyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one;1-methyl-4-(piperidin-4-ylamino)-6-(thiazol-5-yl)quinolin-2(1 H)-one;4-(((1r,4r)-4-(aminomethyl)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)- one;4-(((1s,4s)-4-(aminomethyl)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1 H)- one;4-((((1r,4r)-4-(aminomethyl)cyclohexyl)methyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin- 2(1 H)-one;4-((4-aminophenyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one;4-((4-(aminomethyl)phenyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;4-(((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-1 -methyl-6-(1 H-pyrazol-4-yl)quinolin- 2(1 H)-one;8-(((1 r,4r)-4-hydroxy-4-methylcyclohexyl)amino)-2-(1 H-imidazol-1 -yl)-5-methylpyrido[3,2- d] pyri m id i n-6(5H )-o ne ;2-(1 H-imidazol-1 -yl)-5-methyl-8-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrido[3, 2- d] pyri m id i n-6(5H )-o ne ;2-(1 H-imidazol-1 -yl)-6-methyl-N-((1 r,4r)-4-((2,2,2- trifluoroethyl)amino)cyclohexyl)pyrimidine-4-carboxamide;N-((1r,4r)-4-((2,2-difluoroethyl)amino)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methyl- pyrimidine-4-carboxamide;6-cyclopropyl-N-((1r,4r)-4-((2,2-difluoroethyl)amino)cyclohexyl)-2-(1 H-imidazol-1 - yl )pyri m id i ne-4-carboxa m ide ;6-methyl-2-(1-methyl-1H-imidazol-5-yl)-N-((1r,4r)-4-((2,2,2- trifluoroethyl)amino)cyclohexyl)pyrimidine-4-carboxamide;6-methyl-2-(thiazol-5-yl)-N-((1r,4r)-4-((2,2,2-trifluoroethyl)amino)cyclohexyl)pyrimidine-4- carboxamide;6-methyl-2-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-( (2,2,2- trifluoroethyl)amino)cyclohexyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-6-methyl-N-((1 r,4r)-4-(methyl(2,2,2- trifluoroethyl)amino)cyclohexyl)pyrimidine-4-carboxamide;N-((1r,4r)-4-((2,2-difluoroethyl)amino)cyclohexyl)-6-methyl-2-(thiazol-5-yl)pyrimidine-4- carboxamide;N-((1 r,4r)-4-((2-fluoroethyl)amino)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methylpyrimidine-4- carboxamide;N-((1 r,4r)-4-(3,3-difluoropyrrolidin-1 -yl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methyl- pyrimidine-4-carboxamide;N-((1s,4s)-4-(3,3-difluoropyrrolidin-1-yl)cyclohexyl)-2-(1 H-imidazol-1 -yl )-6- methyl - pyrimidine-4-carboxamide;N-((1 s,4r)-4-((S)-3-fluoropyrrolidin-1 -yl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methyl- pyrimidine-4-carboxamide;N-( (1r,4r )-4-( (R)-3-fluoropyrrolidin-1-yl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methyl- pyrimidine-4-carboxamide;6-methyl-2-(1 H-pyrazol-4-yl)-N-((1 r,4r)-4-((2,2,2- trifluoroethyl)amino)cyclohexyl)pyrimidine-4-carboxamide;N-((1r,4r)-4-((2,2-difluoroethyl)amino)cyclohexyl)-6-methyl-2-(1H-pyrazol-4-yl)pyrimidine- 4-carboxamide;4-cyclopropyl-N-((1r,4r)-4-((2,2-difluoroethyl)amino)cyclohexyl)-6-(1 H-imidazol-1 - yl)picolinamide;N-((1 r,4r)-4-(ethylamino)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methyl30 pyrimidine-4- carboxamide;4-cyclopropyl-6-(1 H-imidazol-1 -yl )-N-((1 r,4r)-4-((2,2,2- trifluoroethyl)amino)cyclohexyl)picolinamide;2-(1 H-imidazol-1 -yl)-6-methyl-N-((1 r,4r)-4-((1 , 1 ,1 -trifluoro-2-methylpropan-2- yl)amino)cyclohexyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-6-methyl-N-((1 S,4r)-4-(((S)-1 , 1 ,1 -trifluoropropan-2- yl)amino)cyclohexyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-6-methyl-N-((1 R,4r)-4-(((R)-1 , 1 ,1 -trifluoropropan-2- yl)amino)cyclohexyl)pyrimidine-4-carboxamide;6-methyl-2-(5-methyl-1 H-imidazol-1 -yl)-N-((1r, 4r)-4-((2, 2,2- trifluoroethyl)amino)cyclohexyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-6-methyl-N-((1 r,4r)-4-(((2,2,2- trifluoroethyl)amino)methyl)cyclohexyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-6-methyl-N-((1 r,4r)-4-((2,2,2- trifluoroethyl)carbamoyl)cyclohexyl)pyrimidine-4-carboxamide;N-((1 r,4r)-4-aminocyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methyl-pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-6-methyl-N-( (1r,4r )-4-( (2,2,2-trifluoroethyl-1,1- d2)amino)cyclohexyl)pyrimidine-4-carboxamide;(Z)-3-(4-methoxyphenyl)-5-((5-nitrothiophen-2-yl)methylene)thiazolidine-2, 4-dione;N5,N6-bis(3-chlorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine;5-chloro-2-hydroxy-N-(naphthalen-1-yl)benzamide;5-(2-aminoethyl)-2-hydroxy-N-(naphthalen-1-yl)benzamide;(E)-5-(2-hydrazineylidenepropyl)-2-hydroxy-N-(6-(2-hydroxycyclopropyl)naphthalen-1- yl)benzamide;5-(2-hydroxy-5-(3-hydroxypropyl)benzamido)-2-naphthoic acid;5-(3-aminopropyl)-2-hydroxy-N-(6-hydroxynaphthalen-1-yl)benzamide;N-(6-aminonaphthalen-1-yl)-2-hydroxy-5-((2-hydroxyethyl)thio)benzamide;N-(6-fluoronaphthalen-1-yl)-2-hydroxy-5-((2-hydroxyethyl)amino)benzamide;5-(2-aminoethoxy)-2-hydroxy-N-(6-methoxynaphthalen-1-yl)benzamide;(E)-2-hydroxy-5-(3-hydroxyprop-1-en-1-yl)-N-(6-(methylsulfonamido)naphthalen-1- yl)benzamide;2-hydroxy-N-(6-(hydroxymethyl)naphthalen-1 -yl)-5-(3-hydroxyprop-1 -yn-1 -yl)benzamide;(E)-2-(5-(5-(3-aminoprop-1-en-1-yl)-2-hydroxybenzamido)naphthalen-2-yl)acetic acid;5-(3-fluoropropyl)-2-hydroxy-N-(6-(trifluoromethyl)naphthalen-1-yl)benzamide;5-(2-hydroxy-5-(2-(hydroxymethyl)cyclopropyl)benzamido)-2-naphthoic acid;5-(2-aminoethyl)-2-hydroxy-4-(2-hydroxyethyl)-N-(naphthalen-1-yl)benzamide;5-(3-aminopropyl)-2-hydroxy-4-(2-hydroxyethoxy)-N-(naphthalen-1-yl)benzamide;5-(3-aminopropyl)-2-hydroxy-4-(2-hydroxyethoxy)-N-(naphthalen-1-yl)benzamide;(E)-2-hydroxy-5-(3-hydroxyprop-1-en-1-yl)-N-(naphthalen-1-yl)-4-(2,2,2- trifluoroethoxy)benzamide;5-(2-aminoethyl)-2-hydroxy-N-(naphthalen-1-yl)benzamide;2-hydroxy-N-(naphthalen-1-yl)-5-(trifluoromethyl)benzamide;(E)-3-(4-hydroxy-3-(naphthalen-1-ylcarbamoyl)phenyl)acrylic acid;5-(2-aminoethyl)-2-hydroxy-N-(1,2,3,4-tetrahydronaphthalen-1-yl)benzamide;5-(3-aminopropyl)-N-(2,3-dihydro-1H-inden-1-yl)-2-hydroxybenzamide;5-(3-aminopropyl)-N-(2,3-dihydro-1H-inden-1-yl)-2-hydroxy-4-(2- hydroxyethoxy)benzamide;(E)-2-hydroxy-5-(3-hydroxyprop-1-en-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1- yl)benzamide;5-chloro-2-hydroxy-N-(1,2,3,4-tetrahydronaphthalen-1-yl)benzamide;2-hydroxy-N-(naphthalen-1-yl)-5-(trifluoromethyl)benzamide;3-(4-hydroxy-3-(naphthalen-1-ylcarbamoyl)phenyl)propanoic acid;2-hydroxy-N-(naphthalen-1-yl)-5-(2-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4- d]imidazol-4-yl)pentanamido)ethyl)benzamide;5-chloro-2-hydroxy-N-(naphthalen-1-yl)benzamide;S-chloro-S-CS-chlorophenylJ-S.IO-dihydro-II^.SJoxadiazoloP'^'^.ejpyrazinop.S- b]quinoxaline;(Z)-3-(4-methoxyphenyl)-5-((5-nitrothiophen-2-yl)methylene)-2-thioxothiazolidin-4-one;3-(1H-imidazol-1-yl)-N-(1,4,4-trimethylpyrrolidin-3-yl)benzamide;N-(1-ethylpiperidin-3-yl)-3-(1H-imidazol-1-yl)benzamide;(S)-N-(1 -ethyl piperid in-3-yl )-3-(1 H-imidazol-1 -yl)benzamide;N-(1 -ethyl-4,4-di methyl pyrrol idin-3-yl)-3-(1H-imidazol-1-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(1-isopropylpiperidin-4-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)benzamide;N-(3-(hydroxymethyl)bicyclo[2.2.1]heptan-2-yl)-3-(1 H-imidazol-1 -yl)benzamide;N-(4-(hydroxymethyl)pyridin-3-yl)-3-(1 H-imidazol-1-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-octahydroindolizin-1 -yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(pyrrolidin-3-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(4-methylpiperidin-3-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(4-methylpiperidin-3-yl)benzamide dihydrochloride;3-(1 H-imidazol-1 -yl)-N-(2-methylpiperidin-3-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(3-methylpiperidin-4-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(3-methylpiperidin-4-yl)benzamide dihydrochloride;N-(3,4-difluorophenyl)-3-(1 H-imidazol-1 -yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(piperidin-3-yl)benzamide;2-fluoro-N-(4-fluorophenyl)-5-(1 H-imidazol-1 -yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(1-propionylpyrrolidin-3-yl)benzamide;N-(1 -azabicyclo[3.2.1 ]octan-5-yl)-3-(1 H-imidazol-1 -yl)benzamide;N-(4-fluorotetrahydrofuran-3-yl)-3-(1 H-imidazol-1 -yl)benzamide;N-((3S,4S)-4-fluorotetrahydrofuran-3-yl)-3-(1 H-imidazol-1-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(2-methyltetrahydrofuran-3-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-((2S,3S)-2-methyltetrahydrofuran-3-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(6-oxaspiro[3.4]octan-2-yl)benzamide;N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-(1 H-imidazol-1 -yl)benzamide;N-(4-(hydroxymethyl)cyclohexyl)-3-(1 H-imidazol-1 -yl)benzamide;N-((1r,4r)-4-(hydroxymethyl)cyclohexyl)-3-(1 H-imidazol-1 -yl)benzamide;N-(1-ethylpiperidin-4-yl)-3-(1 H-imidazol-1-yl)benzamide;N-(2-hydroxycyclohexyl)-3-(1 H-imidazol-1 -yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(4-methylpiperidin-4-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(4-methylpiperidin-4-yl)benzamide dihydrochloride;(S)-3-(1 H-imidazol-1 -yl)-N-(piperidin-3-yl)benzamide;3-(1H-imidazol-1-yl)-N-(piperidin1-3-yl)benzamide dihydrochloride;N-(azetidin-3-yl)-3-(1 H-imidazol-1 -yl)benzamide;N-(azetidin-3-yl)-3-(1 H-imidazol-1 -yl)benzamide dihydrochloride;2-fluoro-N-(3-fluorophenyl)-5-(1 H-imidazol-1 -yl)benzamide;N-cyclopentyl-3-(1 H-imidazol-1 -yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(7-methoxybicyclo[3.2.0]heptan-6- yl)benzamide;N-(3,4-dihydroxycyclopentyl)-3-(1 H-imidazol-1 -yl)benzamide;N-((3R,4S)-3,4-dihydroxycyclopentyl)-3-(1 H-imidazol-1 -yl)benzamide;N-(1-(tert-butyl)piperidin-4-yl)-3-(1 H-imidazol-1 -yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(1-oxidotetrahydro-2H-thiopyran-4-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(2, 2, 5, 5-tetramethyltetrahydrofuran-3-yl)benzamide;N-((1 s,4s)-4- (hydroxymethyl)cyclohexyl)-3-(1 H-imidazol-1 -yl)benzamide;N-(1-(hydroxymethyl)cyclopentyl)-3-(1 H-imidazol-1 -yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(pyrrolidin-3-yl)benzamide dihydrochloride;3-(1 H-imidazol-1 -yl)-N-(2-methylpiperidin-4-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(2-methylpiperidin-3-yl)benzamide dihydrochloride;3-(1 H-imidazol-1 -yl)-N-(piperidin4-yl)benzamide;(S)-3-(1 H-imidazol-1 -yl)-N-(piperidin-3-yl)benzamide dihydrochloride;N-(8-azabicyclo[3.2.1]octan-3-yl)- 3-(1 H-imidazol-1 -yl)benzamide;N-(8-azabicyclo[3.2.1]octan-3-yl)-3-(1 H-imidazol-1 -yl)benzamide dihydrochloride;N-cyclopentyl-2-fluoro-5-(1 H-imidazol-1 -yl)benzamide; methyl 1-(3-(1 H-imidazol-1 -yl)benzamido)cyclopentane-1 -carboxylate;N-(4-hydroxy-1 -methylcyclohexyl )-3-(1 H-imidazol-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(5-oxa-2-azaspiro[3.4]octan-7-yl)benzamide;N-(2-(hydroxymethyl)bicyclo[2.2.2]octan-2-yl)-3-(1 H-imidazol-1-yl)benzamide; methyl 1-(3-(1 H-imidazol-1 -yl)benzamido)-3-hydroxycyclobutane-1 -carboxylate;methyl (1s,3s)-1-(3-(1H-imidazol-1-yl)benzamido)-3-hydroxycyclobutane-1 -carboxylate;3-(1H-imidazol-1-yl)-N-(spiro[3.3]heptan-1-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(2-methoxycyclohexyl)benzamide;3-(1 H-imidazol-1 -yl)-N-((1 R,2R)-2-methoxycyclohexyl)benzamide;N-(2-(hydroxymethyl)-2-methylcyclopentyl)-3-(1 H-imidazol-1 -yl)benzamide;3-(1 H-imidazol-1 -yl)-N-phenyl benzamide;N-(1,1-dioxidotetrahydro-2H-thiopyran-3-yl)-3-(1 H-imidazol-1 -yl)benzamide;N-(4,6-dimethylpyridin-2-yl)-3-(1 H-imidazol-1 -yl)benzamide;2-fluoro-5-(1 H-imidazol-1 -yl)-N-phenylbenzamide;N-(3,3-dichlorocyclobutyl)-3-(1 H-imidazol-1 -yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(1-isobutyrylpiperidin-4-yl)benzamide;N-(1-acetylpiperidin-4-yl)-3-(1H-imidazol-1-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(2-isopropyltetrahydro-2H-pyran-4-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(1-isopropyl-4-methyl pyrrol idin-3-yl)benzamide;N-(4-ethyltetrahydro-2H-pyran-4-yl)-3-(1 H-imidazol-1 -yl)benzamide;N-(2-(hydroxymethyl)cyclohexyl)- 3-(1 H-imidazol-1 -yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(2-methylpiperidin-4-yl)benzamide dihydrochloride;3-(1 H-imidazol-1 -yl)-N-(piperidin4-yl)benzamide dihydrochloride;2-fluoro-N-(2-fluorophenyl)-5-(1 H-imidazol-1 -yl)benzamide;N-cyclohexyl-2-fluoro-5-(1 H-imidazol-1 -yl)benzamide;3-(1H-imidazol-5-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide;N-(1-(4-methoxyphenyl)cyclopentyl)-3-(4H-1,2,4-triazol-4-yl)benzamide;2-bromo-N-(pyridin-3-yl)-5-(4H-1,2,4-triazol-4-yl)benzamide;2-bromo-N-(4-bromophenyl)-5-(4H-1,2,4-triazol-4-yl)benzamide;N-( 4-chlorophenyl)-3-(4H-1 ,2,4-triazol-4-yl)benzamide;2-chloro-N-cyclopentyl-5-(4H-1,2,4-triazol-4-yl)benzamide;N-(4-bromophenyl)-2-chloro-5-(4H-1,2,4-triazol-4-yl)benzamide;N-(tetra hyd ro-2H- pyra n-4-yl )-3-(4H - 1 , 2 ,4-triazol -4-yl )be nza m ide ;N-(1-(2-methoxyphenyl)cyclopentyl)-3-(4H-1 ,2,4-triazol-4-yl)benzamide;2-bromo-N-(pyridin-4-yl)-5-(4H-1,2,4-triazol-4-yl)benzamide;2-bromo-N-cyclohexyl-5-(4H-1 ,2,4-triazol-4-yl)benzamide;N-(1-(2-fluorophenyl)cyclopentyl)-3-(4H-1,2,4-triazol-4-yl)benzamide;2-chloro-N-cyclooctyl-5-(4H-1 ,2,4-triazol-4-yl)benzamide;N-cycloheptyl-3-(4H-1,2,4-triazol-4-yl)benzamide;N-(2-(benzyloxy)cyclopentyl)-3-(4H-1 ,2,4-triazol-4-yl)benzamide;N-((1 R,2R)-2-(benzyloxy)cyclopentyl)-3-(4H-1 ,2,4-triazol-4-yl)benzamide;N-(1-(3-methoxyphenyl)cyclopentyl)-3-(4H-1 ,2,4-triazol-4-yl)benzamide;2-bromo-N-cycloheptyl-5-(4H-1,2,4-triazol-4-yl)benzamide;N-(1 -( 4-methox yphenyl)cyclohexyl)-3-(4H-1 ,2,4-triazol-4-yl)benzamide;N-(4-methylpyridin-2-yl)-3-(4H-1 ,2,4-triazol-4-yl)benzamide;N-(4-fluorophenyl)-3-(4H-1 ,2,4-triazol-4-yl)benzamide;2-chloro-N-cycloheptyl-5-(4H-1 ,2,4-triazol-4-yl)benzamide;2-bromo-N-(5-bromo-6-methylpyridin-2-yl)-5-(4H-1 ,2,4-triazol-4-yl)benzamide;2-bromo-N-(4-fluorophenyl)-5-(4H-1,2,4-triazol-4-yl)benzamide;2-bromo-N-phenyl-5-(4H-1,2,4-triazol-4-yl)benzamide;2-chloro-N-(4-iodophenyl)-5-(4H-1 ,2,4-triazol-4-yl)benzamide;N-(pyrid i n-3-yl )-3-(4H - 1 , 2 ,4-triazol -4-yl )be nza m ide ;N-(pyrid i n-4-yl )-3-(4H - 1 , 2 ,4-triazol -4-yl )be nza m ide ;N-( 4-bromophenyl)-3-(4H-1 ,2,4-triazol-4-yl)benzamide;2-chloro-N-(4-methylpyridin-2-yl)-5-(4H-1 ,2,4-triazol-4-yl)benzamide;2-chloro-N-(2,2,6,6-tetramethylpiperidin-4-yl)-5-(4H-1,2,4-triazol-4-yl)benzamide;2-chloro-N-phenyl-5-(4H-1 ,2,4-triazol-4-yl)benzamide;2-chloro-N-cyclohexyl-5-(4H-1 ,2,4-triazol-4-yl)benzamide;N-(1-(3-fluorophenyl)cyclopentyl)-3-(4H-1,2,4-triazol-4-yl)benzamide;2-chloro-N-(1 -( 4-chlorophenyl)cyclobutyl)-5-(4H-1 ,2,4-triazol-4-yl)benzamide;2-bromo-N-cyclopentyl-5-(4H-1,2,4-triazol-4-yl)benzamide;2-bromo-N-(2-chloro-4-iodophenyl)-5-(4H-1 ,2,4-triazol-4-yl)benzamide;2-bromo-N-(4-methylpyridin-2-yl)-5-(4H-1 ,2,4-triazol-4-yl)benzamide;N-(1-(4-chlorophenyl)cyclobutyl)-3-(4H-1,2,4-triazol-4-yl)benzamide;2-chloro-N-(pyridin-2-yl)-5-(4H-1,2,4-triazol-4-yl)benzamide;N-(5-bromo-6-methylpyridin-2-yl)-2-chloro-5-(4H-1 ,2,4-triazol-4-yl)benzamide;2-chloro-N-(2-iodophenyl)-5-(4H-1,2,4-triazol-4-yl)benzamide;N-(5-bromopyridin-2-yl)-2-chlorol-5-(4H-1,2,4-triazol-4-yl)benzamide;N-(4-(2-hydroxyethyl)phenyl)-3-(1 H-imidazol-1 -yl)benzamide;N-(2-(1 -hydroxyethyl)phenyl)-3-(1 H-imidazol-1 -yl)benzamide;6-(1 H-imidazol-1 -yl)-3-methoxy-N-(pyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(4-iodophenyl)picolinamide;N-(4-bromo-2,5-difluorophenyl)-6-(1 H-imidazol-1 -yl)picolinamide;N-cyclohexyl-6-(1 H-imidazol-1 -yl)picolinamide;4-(difluoromethyl)-6-(1 H-imidazol-1 -yl)-N-(4-(2- methoxyethoxy)cyclohexyl)picolinamide;4-(difluoromethyl)-6-(1 H-imidazol-1 -yl)-N-((1r, 4r)-4-(2- methoxyethoxy)cyclohexyl)picolinamideN-(4-chlorophenyl)-6-(1 H-imidazol-1 -yl)picolinamide;3-fluoro-6-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)picolinamide;4-(1 -hydroxyethyl )-6-(1 H-imidazol-1 -yl)-N-(4-(2-methoxyethoxy)cyclohexyl)picolinamide;4-(1 -hydroxyethyl )-6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2- methoxyethoxy)cyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-4-(2-methoxyethoxy)-N-(2-(trifluoromethyl)pyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(2-(trifluoromethyl)pyridin-4-yl)picolinamide;N-(6-fluoropyridin-3-yl)-6-(1 H-imidazol-1-yl)picolinamide;N-(4-bromophenyl)-6-(1 H-imidazol-1 -yl)picolinamide;N-(4-hydroxycyclohexyl)-6-(1H-imidazol-1-yl)picolinamide;N-((1r,4r)-4-hydroxycyclohexyl)-6-(1 H-imidazol-1 -yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(4-(2-methoxyethoxy)cyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxyethoxy)cyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(3-iodophenyl)picolinamide;5-fluoro-6-(1 H-imidazol-1 -yl)-(pyridin-3-yl)picolinamide;N-(2-fluoropyridin-4-yl)-6-(1 H-imidazol-1 -yl)picolinamide;N-(6-bromopyridin-3-yl)-6-(1 H-imidazol-1 -yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(6-methylpyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-phenylpicolinamide;N-(2,6-dimethylpyridin-4-yl)-6-(1 H-imidazol-1-yl)picolinamide;N-(4-(hydroxymethyl)cyclohexyl)-6-(1 H-imidazol-1 -yl)picolinamide;N-((1s,4s)-4-(hydroxymethyl)cyclohexyl)-6-(1 H-imidazol-1 -yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-methyl-N-(pyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-( 4-(2-methoxyethoxy)cyclohexyl)-4-methylpicolinamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-4-methylpicolinamide;3-amino-6-(1 H-imidazol-1-yl)-(2-(trifluoromethyl)pyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(pyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-3-methyl-N-(pyridin-3-yl)picolinamide;N-(1-(hydroxymethyl)cyclopentyl)-6-(1 H-imidazol-1 -yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-methoxy-N-(pyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-methyl-N-(pyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)picolinamide;N-(3-chloro-2-methylpyridin-4-yl)-6-(1 H-imidazol-1-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(6-(trifluoromethyl)pyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(2-methoxypyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(5-iodo-6-methylpyridin-2-yl)picolinamide;6-(1 H-imidazol-1 -yl)-5-methyl-N-(pyridin-3-yl)picolinamide;N-(2,6-difluoropyridin-4-yl)-6-(1 H-imidazol-1 -yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(6-methoxypyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-methoxy-N-(4-(2-methoxyethoxy)cyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-4-methoxy-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-4-methoxy-N-(2-(trifluoromethyl)pyridin-4-yl)picolinamide;3-amino-6-(1 H-imidazol-1-yl)-N-(pyridin-4-yl)picolinamide;4-(2-hydroxypropan-2-yl)-6-(1 H-imidazol-1 -yl)-N-(4-(2- methoxyethoxy)cyclohexyl)picolinamide;4-(2-hydroxypropan-2-yl)-6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2- methoxyethoxy)cyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(2-methylpyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(pyridin-2-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(4-methoxycyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)picolinamide;3-amino-N-(2-fluoropyridin-4-yl)-6-(1 H-imidazol-1 -yl)picolinamide;6-(1-methyl-1H-imidazol-5-yl)-N-(6-(trifluoromethyl)pyridin-3-yl)picolinamide;6-(1-methyl-1H-imidazol-5-yl)-N-(pyridin-3-yl)picolinamide;4-methyl-6-(1-methyl-1H-imidazol-5-yl)-N-(pyridin-4-yl)picolinamide;N-(2-oxabicyclo[3.2.0]heptan-6-yl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-((1 R,5S,6R)-2-oxabicyclo[3.2.0]heptan-6-yl)-6-(4H-1 ,2,4-triazol-4-yl)picolinamide;3-chloro-N-phenyl-6-(4H-1 ,2,4-triazol-4-yl)picolinamide;3-chloro-N-(3-chlorophenyl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-cyclopentyl-6-(4H-1,2,4-triazol-4-yl)picolinamide;3-bromo-N-cyclohexyl-6-(4H-1 ,2,4-triazol-4-yl)picolinamide;3-bromo-N-(4-methylpyridin-2-yl)-6-(4H-1 ,2,4-triazol-4-yl)picolinamide;N-(4-bromophenyl)-6-(4H-1 ,2,4-triazol-4-yl)picolinamide;N-(2-iodophenyl)-6-(4H-1 ,2,4-triazol-4-yl)picolinamide;N-(octahydroindolizin-8-yl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-((8R,8aR)-octahydroindolizin-8-yl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-cycloheptyl-6-(4H-1,2,4-triazol-4yl)picolinamide;N-cyclohexyl-6-(4H-1 ,2,4-triazol-4-yl)picolinamide;N-(4-iodophenyl)-6-(4H-1 ,2,4-triazol-4-yl)picolinamide;N-(5-bromopyridin-2-yl)-6-(4H-1 ,2,4-triazol-4-yl)picolinamide;3-bromo-N-phenyl-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-(3-chlorophenyl)-6-(4H-1 ,2,4-triazol-4-yl)picolinamide;3-bromo-N-(4-iodophenyl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-(4-fluorophenyl)-6-(4H-1 ,2,4-triazol-4-yl)picolinamide;3-bromo-N-cycloheptyl-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-(4-methylpyridin-2-yl)-6-(4H-1 ,2,4-triazol-4-yl)picolinamide;3-bromo-N-cyclopentyl-6-(4H-1,2,4-triazol-4-yl)picolinamide; methyl 4-(6-(4H-1 ,2,4-triazol-4-yl)picolinamido)-1 -methyl pyrrol idine-2-carboxylate; methyl (2S,4R)-4-(6-(4H-1 ,2,4-triazol-4-yl)picolinamido)-1-methylpyrrolidine-2- carboxylate;3-bromo-N-(pyridin-4-yl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;3-chloro-N-(4-chlorophenyl)-6-(4H-1 ,2,4-triazol-4-yl)picolinamide; ethyl 4-(6-(4H-1 ,2,4-triazol-4-yl)picolinamido)piperidine-1 -carboxylate;N-(pyridin-3-yl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;3-bromo-N-(pyridin-3-yl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-phenyl-6-(4H-1 ,2,4-triazol-4-yl)picolinamide;3-bromo-N-(4-fluorophenyl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-( 4-chlorophenyl)-6-(4H-1 ,2,4-triazol-4-yl)picolinamide;N-(pyridin-4-yl)-6-(4H-l,2,4-triazol-4-yl)picolinamide;6-(thiazol-5-yl)-N-(6-(trifluoromethyl)pyridin-3-yl)picolinamide;N-(2-chlorophenyl)-6-(thiazol-5-yl)picolinamide;N-(4-(2-methoxyethoxy)cyclohexyl)-6-(thiazol-5-yl)picolinamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(thiazol-5-yl)picolinamide;N-(4-(2-hydroxyethyl)phenyl)-6-(1H-imidazol-1-yl)picol inamide;2-(1 H-imidazol-1 -yl)-(spiro[2.5]octan-yl)isonicotinamide;2-(1H-imidazol-1-yl)-N-(2-methylpiperidin-4-yl)isonicotinamide;N-(4-chlorophenyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(piperidin-3-yl)isonicotinamide;N-(bicyclo[4.2.0]octan-7-yl)-2-(1 H-imidazol-1-yl)isonicotinamide;N-((1 R,6R,7S)-bicyclo[ 4.2.0]octan-7-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(1 -(hydroxymethyl)cyclooctyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)isonicotinamide;N-(3,3-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(4-methylcyclohexyl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methylcyclohexyl)isonicotinamide;N-(1 -ethyl -6-oxo- 1 ,6-dihydropyridin-3-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(4-(2-methoxyethoxy)cyclohexyl)-6-methyl isonicotinamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-methyl isonicotinamide;N-(2,4-dimethylcyclohexyl)-2-(1H-imidazol-1-yl)isonicotinamide;2-(1H-imidazol-1-yl)-N-(6-methoxypyridin-3-yl)isonicotinamide;2-(1H-imidazol-1-yl)-N-(4-(trifluoromethyl)cyclohexyl)isonicotinamide;N-(hexahydro-3aH-cyclopenta[b]furan-3a-yl)-2-(1H-imidazol-1-yl)isonicotinamide;N-((3aR,6aS)-hexahydro-3aH-cyclopenta[b]furan-3a-yl)-2-(1H-imidazol-1- yl)isonicotinamide;N-((3aS,6aR)-hexahydro-3aH-cyclopenta[b]furan-3a-yl)-2-(1H-imidazol-1- yl)isonicotinamide;2-(1H-imidazol-1-yl)-N-(2,4,4-trimethylcyclohexyl)isonicotinamide2-(1 H-imidazol-1 -yl)-N-(piperidin-3-yl)isonicotinamide dihydrochloride;(S)-2-(1 H-imidazol-1 -yl)-N-(piperidin-3-yl)isonicotinamide;(S)-2-(1 H-imidazol-1 -yl)-N-(piperidin-3-yl)isonicotinamide dihydrochloride;2-(1 H-imidazol-1 -yl)-N-(tetrahydro-2H-thiopyran-4-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(3-methylpiperidin-4-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(3-methylpiperidin-4-yl)isonicotinamide dihydrochloride; methyl 1-(2-(1 H-imidazol-1 -yl)isonicotinamido)-4-methylcyclohexane-1 -carboxylate;2-(1 H-imidazol-1 -yl)-N-(octahydrobenzofuran-4-yl)isonicotinamide;N-(2,6-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(2-(hydroxymethyl)cycloheptyl)-2-(1 H-imidazol-1-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(1, 4, 4-trimethylpyrrolidin-3-yl)isonicotinamide;N-(azetidin-3-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(azetidin-3-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide dihydrochloride;2-(1 H-imidazol-1 -yl)-N-(4-methylpiperidin-4-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(4-methylpiperidin-4-yl)isonicotinamide dihydrochloride;N-(4-(tert-butoxy)pyridin-3-yl)-2-(1 H-imidazol-1-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(piperidin-4-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(piperidin-4-yl)isonicotinamide dihydrochloride;N-(2,2-dimethylcyclohexyl)-2-(1H-imidazol-1-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(4-methylpiperidin-3-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(4-methylpiperidin-3-yl)isonicotinamide dihydrochloride;2-(1 H-imidazol-1 -yl)-N-(2, 2, 6, 6-tetramethylpiperidin-4-yl)isonicotinamide;2-(1 H-imidazol-1 -yl )- N-( 1 methylcyclopentyl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(1, 7, 7-trimethylbicyclo[2.2.1]heptan-2-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(3-methoxy-2, 2, 3-trimethylcyclobutyl)isonicotinamide;N-(3-chlorophenyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(1 -isopropyl pyrrol idin-3-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(1-(trifluoromethyl)cyclobutyl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(2-methylpiperidin-3-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(2-methylpiperidin-3-yl)isonicotinamide dihydrochloride;2-(1 H-imidazol-1 -yl)-N-(7-methoxybicyclo[3.2.0]heptan-6-yl)isonicotinamide;N-(1-(tert-butyl)pyrrolidin-3-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(2-(tert-butyl)cyclopentyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(1-ethylpiperidin-3-yl)-2-(1 H-imidazol-1-yl)isonicotinamide;N-cyclooctyl-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(2-methylpiperidin-1 -yl)isonicotinamide;N-(2,3-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-( 4,4-difluorocyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(1-(hydroxymethyl)cyclopentyl)-2-(1 H-imidazol-yl)isonicotinamide;N-(1 -azabicyclo[3.2.1 ]octan-5-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(8-azabicyclo[3.2.1]octan-3-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(8-azabicyclo[3.2.1]octan-3-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide dihydrochloride;N-(4-hydroxy-1 -methylcyclohexyl )-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(pyrrolidin-3-yl)isonicotinamide;2-(1H-imidazol-1-yl)-N-(pyrrolidin-3-yl)isonicotinamide dihydrochloride;N-(6-(2,2-difluoroethoxy)pyridin-2-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(octahydroindolizin-1-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(4-methoxycyclohexyl)isonicotinamide;N-(4,4-difluoro-1-methylcyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(1,4-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(spiro[2.5]octan-5-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(3-(trifluoromethyl)cyclohexyl)isonicotinamide;N-(1-ethylcyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(2-isopropyltetrahydro-2H-pyran-4-yl)isonicotinamide;N-(3,3-dimethoxycyclobutyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(1 ,2-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(3-iodophenyl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(1-methylpiperidin-4-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(4-(2-methoxyethoxy)cyclohexyl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(spiro[3.5]nonan-5-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(octahydro-1 H-inden-5-yl)isonicotinamide;N-(2-(hydroxymethyl)cyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(3,4-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(7,7-dimethyl-2-oxabicyclo[3.2.0]heptan-6-yl)-2-(1H-imidazol-1-yl)isonicotinamide;N-(2-(hydroxymethyl)-2-methylcyclopentyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(2-methylpiperidin-4-yl)isonicotinamide dihydrochloride;N-(4-bromophenyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl )- N-( 1 phenylpiperidin-4-yl)isonicotinamide;N-(bicyclo[4.1.0]heptan-2-yl)-2-(1H-imidazol-1-yl)isonicotinamide;2-(1 H-imidazol-1-yl)-N-(5-oxo-1 -phenyl pyrrol idin-3-yl)isonicotinamide;N-(bicyclo[2.2.1]heptan-1-yl)-2-(1H-imidazol-1-yl)isonicotinamide;N-(2,5-dimethyltetrahydrofuran-3-yl)-2-(1H-imidazol-1-yl)isonicotinamide;N-(2-fluorophenyl)-2-(1H-imidazol-1-yl)isonicotinamide;2-(1H-imidazol-1-yl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)isonicotinamide;N-(3,5-dimethylcyclohexyl)-2-(1H-imidazol-1-yl)isonicotinamide;N-(2-hydroxycyclohexyl)-2-(1H-imidazol-1-yl)isonicotinamide;2-(1H-imidazol-1-yl)-N-(6-oxaspiro[3.4]octan-2-yl)isonicotinamide;N-(3-fluorocyclohexyl)-2-(1H-imidazol-1-yl)isonicotinamide;N-(1 -ethyl-4,4-di methyl pyrrol idin-3-yl)-2-(1H-imidazol-1-yl)isonicotinamide;2-(1H-imidazol-1-yl)-N-(2-methyltetrahydrofuran-3-yl)isonicotinamide;2-(1H-imidazol-1-yl)-N-((2S,3S)-2-methyltetrahydrofuran-3-yl)isonicotinamide; ethyl 1 -(2-(1 H-imidazol-1 -yl)isonicotinamido)cyclopentane-1 -carboxylate;N-(3-bromophenyl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-(4-fluorophenyl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-(3-chlorophenyl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-(2-iodophenyl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-(pyridin-3-yl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-(pyridin-4-yl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-(4-chlorophenyl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-(2-chlorophenyl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-(5-bromopyridin-2-yl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-(4-bromophenyl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-phenyl-2-(4H-l,2,4-triazol-4-yl)isonicotinamide;N-(4-methylpyridin-2-yl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-(pyridin-2-yl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-(4-iodophenyl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-(4-(2-methoxyethoxy)cyclohexyl)-2-(thiazol-5-yl)-6-(trifluoromethyl)isonicotinamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2-(thiazol-5-yl)-6-(trifluoromethyl)isonicotinamideN-(2-(1 -hydroxyethyl)phenyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(3-(hydroxymethyl)phenyl)-2-(1H-imidazol-1-yl)isonicotinamide;N-(2,4-dimethylcyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(3-isopropylcyclohexyl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(1-isopropylpiperidin-4-yl)picolinamide;N-(4-(hydroxymethyl)cyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;N-((1 r,4r)-4-(hydroxymethyl)cyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(3-ethoxyspiro[3.5]nonan-1-yl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(4-methyltetrahydro-2H-pyran-4-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(3-methyltetrahydro-2H-pyran-3-yl)picolinamide;N-(2-ethylcyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(1-acetylpiperidin-4-yl)-4-(1H-imidazol-1-yl)picolinamide;N-(1-(hydroxymethyl)cyclopentyl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(2-oxabicyclo[4.2.0]octan-7-yl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(1-(tert-butyl)piperidin-4-yl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(6-oxaspiro[3.4]octan-2-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(2-isopropyltetrahydro-2H-pyran-4-yl)picolinamide;N-(2,2-dimethylcyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(4-fluorotetrahydrofuran-3-yl)-4-(1 H-imidazol-1 -yl)picolinamide;N-((3S,4S)-4-fluorotetrahydrofuran-3-yl)-4-(1H-imidazol-1-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(2-methyltetrahydrofuran-3-yl)picolinamide;4-(1H-imidazol-1-yl)-N-((2S,3S)-2-methyltetrahydrofuran-3-yl)picolinamide;N-(2,3-dimethyltetrahydrofuran-3-yl)-4-(1 H-imidazol-yl)picolinamide;N-(4,4-dimethylcyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(2-(hydroxymethyl)cyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(1 -(hydroxymethyl)-3,3,5-trimethylcyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(1 ,2-dimethylpiperidin-4-yl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(2-methylcyclohexyl)picolinamide;N-(1,1-dioxidotetrahydro-2H-thiopyran-3-yl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(4,4-difluorocyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(1-isobutyrylpiperidin-4-yl)picolinamide;N-(1-(tert-butyl)-5-oxopyrrolidin-3-yl)-4-(1 H-imidazol-1 -yl)picolinamide;N-cyclobutyl-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(4-isopropylcyclohexyl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(2, 2, 5, 5-tetramethyltetrahydrofuran-3-yl)picolinamide;N-(1,4-dimethylcyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(2-methoxycyclohexyl)picolinamide;4-(1 H-imidazol-1 -yl)-N-((1S,2S)-2-methoxycyclohexyl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(2-isopropylcyclohexyl)picolinamide;N-(1 -acetyl pyrrolidin-3-yl)-4-(1H-imidazol-1-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)picolinamide;N-(1-ethylpiperidin-3-yl)-4-(1 H-imidazol-1-yl)picolinamide;(S)-N-(1-ethylpiperidin-3-yl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(4-methylcycloheptyl)picolinamideN-(1-ethylpiperidin-4-yl)-4-(1 H-imidazol-1-yl)picolinamide;N-(8,8-dimethyl-2-oxabicyclo[4.2.0]octan-7-yl)-4-(1H-imidazol-1-yl)picolinamide;4-(1H-imidazol-1-yl)-N-(2-methyltetrahydro-2H-pyran-4-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(3-methylcyclohexyl)picolinamide;4-(1H-imidazol-1-yl)-N-(3-methyltetrahydrofuran-3-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(3-(trifluoromethyl)cyclohexyl)picolinamide;N-(2-(hydroxymethyl)-2-methylcyclopentyl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(2-hydroxycyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(4-(trifluoromethyl)cyclohexyl)picolinamide;N-(2,3-dimethylcyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(tetrahydro-2H-pyran-3-yl)picolinamide;N-(1 -ethyl-4,4-di methyl pyrrol idin-3-yl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(1-isopropyl-4-methyl pyrrol idin-3-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(3-methoxycyclopentyl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(octahydro-1 H-inden-5-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(1-methylpiperidin-4-yl)picolinamide;N-(2,2-dimethylcyclopentyl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(tetrahydro-2H-pyran-4-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(4-methylcyclohexyl)picolinamide;4-(1 H-imidazol-1 -yl)-N-((1 ,4r)-4-methylcyclohexyl)picolinamide;N-(1,1-dioxidotetrahydrothiophen-3-yl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(3-ethylcyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(1-methylcyclohexyl)picolinamide;N-(4-ethylcyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(1-methyl-6-oxopiperidin-3-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(1-methyl-2-oxopiperidin-3-yl)picolinamide;N-(3,5-dimethylcyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;2-(1 H-imidazol-1 -yl)-N-(4-(2-methoxy-2-methyl propoxy )cyclohexyl)-6-methylpyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxy-2-methyl propoxy )cyclohexyl)-6- methylpyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-6-methyl-N-(pyridin-4-yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-6-methyl-N-(pyridin-3-yl)pyrimidine-4-carboxamide;6-(difluoromethyl)-2-(1H-imidazol-1-yl)-N-(4-(2-methoxyethoxy)cyclohexyl)pyrimidine-4- carboxamide;6-(difluoromethyl)-2-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)pyrimid i ne-4-carboxa m ide ;5-chloro-N-(2-chlorophenyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide;N-(4-ethoxycyclohexyl)-2-(1H-imidazol-1-yl)pyrimidine-4-carboxamide;N-((1 r,4r)-4-ethoxycyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;6-(fluoromethyl)-2-(1 H-imidazol-1 -yl)-N-(4-(2-methoxyethoxy)cyclohexyl)pyrimidine-4- carboxamide;6-(fluoromethyl)-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2- methoxyethoxy)cyclohexyl ) pyri m id i ne-4-carboxa m ide ;2-(1 H-imidazol-1 -yl)-N-(3-(2-methoxyethoxy)cyclobutyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,3r)-3-methoxyethoxy)cyclobutyl)pyrimidine-4-carboxamide;5-bromo-N-(3,4-dichlorophenyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;6-ethoxy-2-(1H-imidazol-1-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-(4-(2-methoxyethoxy)cyclohexyl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6- (trifluoromethyl)pyrimidine-4-carboxamide;5-bromo-N-(2-chlorophenyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide;N-(4-hydroxy-4-methylcyclohexyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide;N-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-2-(1H-imidazol-1-yl)pyrimidine-4-carboxamide;N-((1 s,4s)-4-hydroxy-4-methylcyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-6-methoxy-N-(2-(trifluoromethyl)pyridin-4-yl)pyrimidine-4- carboxamide;N-(4-(difluoromethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methylpyrimidine-4- carboxamide;N-((1 r,4r)-4-(difluoromethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methylpyrimidine-4- carboxamide;6-cyclopropyl-2-(1 H-imidazol-1 -yl)-N-(4-(2-methoxyethoxy)cyclohexyl)pyrimidine-4- carboxamide;6-cyclopropyl-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)pyrimidine- 4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(4-(2-methoxyethoxy)cyclohexyl)-6-methylpyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-methylpyrimidine-4- carboxamide;6-(hydroxymethyl)-2-(1 H-imidazol-1 -yl)-N-(4-(2-methoxyethoxy)cyclohexyl)pyrimidine-4- carboxamide;6-(hydroxymethyl)-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2- methoxyethoxy)cyclohexyl)pyrimidine-4-carboxamide;5-chloro-2-(1 H-imidazol-1-yl)-N-phenylpyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(4-methoxycyclohexyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrimidine-4-carboxamide;5-bromo-N-(4-chlorophenyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(4-(2-methoxyethoxy)cyclohexyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxyethoxy)cyclohexyl)pyrimidine-4-carboxamide;N-(4-(difluoromethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;N-((1 r,4r)-4-(difluoromethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;5-bromo-N-(2-fluorophenyl)-2-(1H-imidazol-1-yl)pyrimidine-4-carboxamide;N-(4-hydroxycyclohexyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide;N-((1r,4r)-4-hydroxycyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;6-cyclopropyl-2-(1 H-imidazol-1 -yl)-N-(2-(trifluoromethyl)pyridine-4-yl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-(4-methoxy-4-methylcyclohexyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxy-4-methylcyclohexyl)pyrimidine-4-carboxamide; 5-chloro-N-(2-fluorophenyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;5-chloro-N-(4-fluorophenyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-6-(2-methoxyethoxy)-N-(2-(trifluoromethyl)pyridin-4-yl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl-d3)-N-(4-(2-methoxyethoxy)cyclohexyl)-6-methylpyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl-d3)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-methylpyrimidine-4- carboxamide;6-(2-methoxyethoxy)-2-(1 -methyl-1 H-imidazol-5-yl)-N-(2-(trifluoromethyl)pyridin-4- 0-0 / yl )pyri m id i ne-4-carboxa m ide ;6-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)pyrazine-2-carboxamide;3-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-methoxycyclohexyl)-5-methylbenzamide;3-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-methoxycyclohexyl)-5-(1 -methyl-1 H-pyrazol-4- yl)benzamide;3-((R)-2-(hydroxymethyl)pyrrolidin-1-yl)-5-(1 H-imidazol-1 -yl)-N-((1r,4R)-4- methoxycyclohexyl)benzamide;3-((S)-2-hydroxypyrrolidin-1 -yl )-5-(1 H-imidazol-1 -yl )- N-((1 r,4S)-4- methoxycyclohexyl)benzamide;3-((R)-2-(hydroxymethyl)pyrrolidin-1-yl)-N-((1r,4R)-4-methoxycyclohexyl)-5-(thiazol-5- yl)benzamide;N-((1r,4r)-4-methoxycyclohexyl)-3-(1-methyl-1H-pyrazol-4-yl)-5-(thiazol-5-yl)benzamide;N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-3-(1 -methyl-1 H-pyrazol-4-yl)-5-(thiazol-5- yl)benzamide;3-(4-(hydroxymethyl)-1H-imidazol-1-yl)-5-(2-methoxyethoxy)-N-(2- (trifluoromethyl)pyridin-4-yl)benzamide;3-(1H-imidazol-1-yl)-N-(isoquinolin-7-yl)-5-(2-methoxyethoxy)benzamide;3-(1H-imidazol-1-yl)-N-(isochroman-6-yl)-5-(2-methoxyethoxy)benzamide;N-(2-(tert-butyl)pyrimidin-5-yl)-3-(1H-imidazol-1-yl)-5-(2-methoxyethoxy)benzamide;N-(6-cyanopyridin-3-yl)-3-(1H-imidazol-1-yl)-5-(2-methoxyethoxy)benzamide;N-(5-chloropyridin-3-yl)-3-(1H-imidazol-1-yl)-5-(2-methoxyethoxy)benzamide;3-(2-(dimethylamino)ethoxy)-5-(1H-imidazol-1-yl)-N-(2-(trifluoromethyl)pyridin-4- yl)benzamide;N-(5-chloropyridin-3-yl)-3-cyclopropoxy-5-(1H-imidazol-1-yl)benzamide;3-(1H-imidazol-1-yl)-5-(2-methoxyethoxy)-N-(quinolin-7-yl)benzamide;N-(3-chloro-4-fluorophenyl)-3-(1H-imidazol-1-yl)-5-(2-methoxyethoxy)benzamide;3-(1H-imidazol-1-yl)-5-(2-methoxyethoxy)-N-(6-(trifluoromethyl)pyridin-3-yl)benzamide;2-chloro-5-(1H-imidazol-1-yl)-3-(2-methoxyethoxy)-N-(2-(trifluoromethyl)pyridin-4- yl)benzamide;3-(1H-imidazol-1-yl)-5-(2-methoxyethoxy)-N-(2-(trifluoromethyl)pyridin-4-yl)benzamide;3-(1H-imidazol-1-yl)-5-methoxy-N-(2-(trifluoromethyl)pyridin-4-yl)benzamide;3-(2-methoxyethoxy)-5-(thiazol-5-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)benzamide;2-fluoro-5-(1H-imidazol-1-yl)-3-(2-methoxyethoxy)-N-(2-(trifluoromethyl)pyridin-4- yl)benzamide;3-(5-(hydroxymethyl)-1H-imidazol-1-yl)-5-(2-methoxyethoxy)-N-(2-(trifluoromethyl)pyridin-4-yl)benzamide;3-(5-(hydroxymethyl)-1H-imidazol-1-yl)-5-methoxy-N-(2-(trifluoromethyl)pyridin-4- yl)benzamide;3-(2-methoxyethoxy)-5-(pyridin-3-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)benzamide;3-(4-hydroxy-1 H-pyrazol-1-yl)-5-(2-methoxyethoxy)-N-(2-(trifluoromethyl)pyridin-4- yl)benzamide;3-(4-amino-1 H-pyrazol-1-yl)-5-(2-methoxyethoxy)-N-(2-(trifluoromethyl)pyridin-4- yl)benzamide;N-(1 H-imidazo[4,5-c]pyridin-2-yl)-3-(1 H-imidazol-1 -yl)-5-(2-methoxyethoxy)benzamide;3-(1 H-imidazol-1 -yl)-5-(2-methoxyethoxy)-N-(4-phenyl-1 H-imidazol-2-yl)benzamide;N-(4-cyclopropyl-1 H-imidazol-2-yl)-3-(1 H-imidazol-1 -yl)-5-(2-methoxyethoxy)benzamide;3-(1 H-imidazol-1 -yl )- N-( 1 H-indazol-5-yl)-5-(2-methoxyethoxy)benzamide;N-(1H-benzo[d]imidazol-5-yl)-3-(1 H-imidazol-1 -yl)-5-(2-methoxyethoxy)benzamide;3-(1 H-imidazol-1 -yl)-5-(2-methoxyethoxy)-N-(quinoxalin-6-yl)benzamide;3-(1 H-imidazol-1 -yl)-5-morpholino-N-(2-(trifluoromethyl)pyridin-4-yl)benzamide;(S)-3-(1 H-imidazol-1 -yl)-5-(3-(methoxymethyl)pyrrolidin-1-yl)-N-(2- (trifluoromethyl)pyridin-4-yl)benzamide;(S)-3-(3-(hydroxymethyl)pyrrolidin-1-yl)-5-(1 H-imidazol-1 -yl)-N-(2-(trifluoromethyl)pyridin- 4-yl )benzam ide;(R)-3-(2-(hydroxymethyl)pyrrolidin-1-yl)-5-(1 H-imidazol-1 -yl)-N-(2-(trifluoromethyl)pyridin- 4-yl )benzam ide;3-(1-methyl-1H-pyrazol-4-yl)-5-(thiazol-5-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)benzamide;3-(1 H-imidazol-1 -yl )-5-( 1 -methyl-1 H-pyrazol-4-yl)-N-(2-(trifluoromethyl)pyridin-4- yl)benzamide;3-(5-(hydroxymethyl)-1 H-imidazol-1 -yl)-5-(1 -methyl-1 H-pyrazol-4-yl)-N-(2- (trifluoromethyl)pyridin-4-yl)benzamide;3-(1 H-imidazol-1 -yl)-5-(piperazin-1-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)benzamide;N-((1 r,4r)-4-((2-Hydroxy-2-(trifluoromethyl)butyl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl)- 1 H-indole-7-carboxamide;N-((1 s,4s)-4-((2-Hydroxy-2-(trifluoromethyl)butyl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-indole-7-carboxamide;5-(1 H-lmidazol-1 -yl)-N-((1 R,4r)-4-(((R)-1 , 1 ,1 -trifluoro-3-hydroxy-2-methylpropan-2- yl)amino)cyclohexyl)-1 H-indole-7-carboxamide;N-((1 r, 4r)-4-(2-Hydroxy-2-methyl propoxy )cyclohexyl)-5-(1 H-imidazol-1 -yl)-3-isopropyl- 1 H-indole-7-carboxamide;5-(1 H-lmidazol-1 -yl)-N-((1s, 4s)-4-(methylcarbamoyl)cyclohexyl)-1 H-indole-7- carboxamide;5-(1 H-imidazol-1 -yl)-N-((1s, 4s)-4-(2-methoxyethoxy)cyclohexyl)-1H-indole-7- carboxamide;N-((1 r,4r)-4-(2-Hydroxy-2-methyl propoxy )cyclohexyl)-5-(1 H-imidazol-1-yl)-1 H-indole-7- carboxamide;N-((1 r,4r)-4-(2-Hydroxypropoxy)cyclohexyl)-5-(1 H-imidazol-1-yl)-1 H-indole-7-Carboxamide;3-Chloro-N-((1 r,4r)-4-(2-hydroxypropoxy)cyclohexyl)-5-(1 H-imidazol-1 -1 -yl )- 1 H-indole-7- carboxamide;5-(1 H-lmidazol-1 -yl )- N-((1 r,4r)-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropoxy)cyclohexyl)- 1 H-indole-7-carboxamide;5-1 H-lmidazol-1 -yl)-N-((1r, 4r)-4-((3, 3, 3-trifluoro-2-hydroxy-2- methylpropyl)amino)cyclohexyl)-1 H-indole-7-carboxamide;5-1 H-lmidazol-1 -yl)-N-((1r, 4r)-4-(3, 3, 3-trifluoro-2-hydroxy-2- methylpropanamido)cyclohexyl)-1H-indole-7-carboxamide;N-((1 r,4r)-4-((2,2-Difluoroethyl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl )-1 H-indole-7- carboxamide;3-Chloro-N-((1 r,4r)-4-((2,2-difluoroethyl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H- indole-7-carboxamide;N-((1 r,4r)-4-(2-Hydroxy-3-methylbutoxy)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-indole-7- carboxamide;N-((1 r,4r)-4-(2-Cylopropyl-2-hydroxypropoxy)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H- indole-7-carboxamide;5-(1 H-lmidazol-1 -yl)-N-((1R, 4r)-4-(((R)-1-(methylsulfonylpropan-2-yl)amino)cyclohexyl)- 1 H-indole-7-carboxamide;4-((4-chloro-3-fluorophenyl)amino)-6-(thiazol-5-yl)quinoline-3-carboxamide;N-(4-chloro-3-fluorophenyl)-6-(thiazol-5-yl)quinolin-4-amine;N-phenyl-6-(thiazol-5-yl)quinazolin-4-amine;N-(4-chloro-3-fluorophenyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(4-chlorophenyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(3-chlorophenyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(2-chlorophenyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(4-fluorophenyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(3-fluorophenyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(2-fluorophenyl)-6-(thiazol-5-yl)quinazolin-4-amine;6-(thiazol-5-yl)-N-(p-tolyl)quinazolin-4-amine;6-(thiazol-5-yl)-N-(m-tolyl)quinazolin-4-amine;6-(thiazol-5-yl)-N-(o-tolyl)quinazolin-4-amine;6-(thiazol-5-yl)-N-(3-(trifluoromethyl)phenyl)quinazolin-4-amine;4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)benzenesulfonamide;N-(4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)phenyl)methanesulfonamide;N-(3-(methylsulfonyl)phenyl)-6-(thiazol-5-yl)quinazolin-4-amine;4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)benzamide;N-(4-(isoxazol-5-yl)phenyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(4-(1H-imidazol-1-yl)phenyl)-6-(thiazol-5-yl)quinazolin-4-amine;1-(4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)phenyl)piperidin-2-one;N-(pyridin-2-yl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(pyridin-3-yl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(pyrid i n-4-yl )-6-(th iazol-5-yl )qu i nazol i n-4-a m i ne ;N-cyclopropyl-6-(thiazol-5-yl)quinazolin-4-amine;N-cyclobutyl-6-(thiazol-5-yl)quinazolin-4-amine;N-cyclopentyl-6-(thiazol-5-yl)quinazolin-4-amine;N-cyclohexyl-6-(thiazol-5-yl)quinazolin-4-amine;N-(tetrahydrofuran-2-yl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(tetra hyd ro-2H- pyra n-4-yl )-6-(th iazol -5-yl )qu i nazol i n-4-a mine;N-(tetra hyd ro-2H- pyra n-3-yl )-6-(th iazol -5-yl )qu i nazol i n-4-a mine;N-(piperidin-4-yl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(piperidin-3-yl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(piperidin-2-yl)-6-(thiazol-5-yl)quinazolin-4-amine;4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)piperidine-1-carbaldehyde;4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)tetrahydro-2H-thiopyran1,1 -dioxide;N-(4-methylcyclohexyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(trans-2-methylcyclohexyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(cis-2-methylcyclohexyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(3-methylcyclohexyl)-6-(thiazol-5-yl)quinazolin-4-amine;4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)cyclohexan-1-ol;(1r,4r)-4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)cyclohexane-1-carboxamide;(1s,3s)-3-((6-(thiazol-5-yl)quinazolin-4-yl)amino)cyclohexane-1-carboxamide;(1r,4r)-N-ethyl-4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)cyclohexane-1-carboxamide;(1s,4s)-4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)cyclohexane-1-carboxylicacid;(1r,4r)-4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)cyclohexane-1-carboxylicacid;1-((1s,4s)-4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)cyclohexyl)piperidin-2-one;1-((1r,4r)-4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)cyclohexyl)piperidin-2-one;N-ethyl -6-(th iazol -5-yl )qu i nazol i n-4-am i ne ;N-isopropyl-6-(thiazol-5-yl)quinazolin-4-amine;N-(tert-butyl)-6-(thiazol-5-yl)quinazolin-4-amine;2-((6-(thiazol-5-yl)quinazolin-4-yl)amino)ethan-1-ol;N-(2-methoxyethyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(3-Chloro-4-fluorophenyl)-8-methoxy-6-(thiazol-5-yl)-quinazolin-4-amine;4-{[8-(Methyloxy)-6-(1,3-thiazol-5-yl)-4-quinazolinyl]amino}-benzamide;N-(3-Chloro-4-fluorophenyl)-6-(1,3-thiazol-5-yl)-8-(trifluoromethyl)-4-quinazolinamine;4-{[6-(1,3-Thiazol-5-yl)-8-(trifluoromethyl)-4-quinazolinyl]-amino}benzamide;N-(3-Chloro-4-fluorophenyl)-8-methyl-6-(1,3-thiazol-5-yl)-4-quinazolinamine;4-((3-Chloro-4-fluorophenyl)amino)-8-methyl-6-(thiazol-5-yl)quinazolin-2(1H)-one;4-(((1s,4s)-4-Methoxycyclohexyl)amino)-8-methyl-6-(thiazol-5-yl)quinazolin-2(1H)-one;4-(((1s,4s)-4-(2-Methoxyethoxy)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinazolin- 2(1H)-one;4-(((1s,4s)-4-Methoxycyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinazolin-2(1H)-one;(1s,4s)-N-Methyl-4-((2-methyl-6-(thiazol-5-yl)-8-(trifluoromethyl)quinazolin-4-yl)amino)- cyclohexanecarboxamide;(1s,4s)-N-Methyl-4-((8-methyl-6-(thiazol-5-yl)-2-(trifluoromethyl)quinazolin-4-yl)amino)- cyclohexanecarboxamide;(1s,4s)-4-((2,8-Dimethyl-6-(thiazol-5-yl)quinazolin-4-yl)-amino)-N- methylcyclohexanecarboxamide;(1s,4s)-N-Methyl-4-((2-oxo-6-(thiazol-5-yl)-1,2-dihydroquinolin-4- yl)amino)cyclohexanecarboxamide;4-((Tetrahydro-2H-pyran-4-yl)amino)-6-(thiazol-5-yl)-quinolin-2(1H)-one;4-(((1s,4s)-4-(2-Methoxyethoxy)cyclohexyl)amino)-6-(thiazol-5-yl)quinolin-2(1H)-one;(1r,4r)-N-Methyl-4-((8-methyl-2-oxo-6-(thiazol-5-yl)-1,2-dihydroquinolin-4- yl)amino)cyclohexanecarboxamide;8-Methyl-4-((tetrahydro-2H-pyran-4-yl)amino)-6-(thiazol-5-yl)quinolin-2(1H)-one;4-(((1s,4s)-4-(2-Methoxyethoxy)cyclohexyl)amino)-8-methyl-6-(thiazol-5-yl)quinolin- 2(1H)-one;4-(((1s,4s)-4-Methoxycyclohexyl)amino)-8-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one;(1r,4r)-N-Methyl-4-((1-methyl-2-oxo-6-(thiazol-5-yl)-1,2-dihydroquinolin-4- yl)amino)cyclohexanecarboxamide;1-Methyl-4-((tetrahydro-2H-pyran-4-yl)amino)-6-(thiazol-5-yl)quinolin-2(1H)-one;4-(((1 r,4r)-4-(2-Methoxyethoxy)cyclohexyl)amino)-1 -methyl6-(thiazol-5-yl)quinolin-2(1 H)- one;4-(((1r,4r)-4-Methoxycyclohexyl)amino)-1-methyl-6-(thiazol5-yl)quinolin-2(1H)-one;4-(((1s,4s)-4-Hydroxycyclohexyl)amino)-1-methyl-6-(thiazol5-yl)quinolin-2(1 H)-one trifluoroacetic Acid salt;4-Amino-1-methyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;(1 r,4r)-4-((1 ,8-Dimethyl-2-oxo-6-(thiazol-5-yl)-1 ,2-dihydroquinolin-4-yl)amino)-N- methylcyclohexanecarboxamide;1,8-Dimethyl-4-((tetrahydro-2H-pyran-4-yl)amino)-6-(thiazol-5-yl)quinolin-2(1H)-one;4-(((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)amino)-1 ,8-dimethyl-6-(thiazol-5-yl)quinolin- 2(1 H)-one;4-(((1 r,4r)-4-Methoxycyclohexyl)amino)-1 ,8-dimethyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;(1r,4r)-4-((1-Ethyl-2-oxo-6-(thiazol-5-yl)-1,2-dihydroquinolin-4-yl)amino)-N- methylcyclohexanecarboxamide;1-Ethyl-4-(((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-6-(thiazol-5-yl)quinolin-2(1H)- one;4-{[(2,6-Dimethylphenyl)methyl]amino}-2-methyl-8-quinolinecarboxamide;4-Amino-2-methyl-8-quinolinecarboxamide;4-(Benzylamino)-2-methylquinoline-8-carboxamide;2-Methyl-4-(2-methylbenzylamino)quinoline-8-carboxamide;2-Methyl-4-(2-methylbenzylamino)quinoline-8-carboxamide;4-((2-Methoxybenzyl)amino)-2-methylquinoline-8-carboxamide;2-Methyl-4-((3-methylbenzyl)amino)quinoline-8-carboxamide;4-{[(3-Chlorophenyl)methyl]amino}-2-methyl-8-quinolinecarboxamide;4-((3-Methoxybenzyl)amino)-2-methylquinoline-8-carboxamide;2-Methyl-4-((4-methylbenzyl)amino)quinoline-8-carboxamide;4-(4-Chlorobenzylamino)-2-methylquinoline-8-carboxamide;4-((4-Methoxybenzyl)amino)-2-methylquinoline-8-carboxamide;2-Methyl-4-(2-(trifluoromethyl)benzylamino)quinoline-8-carboxamide;4-(2-Bromobenzylamino)-2-methylquinoline-8-carboxamide;4-(2-Carbamoylbenzylamino)-2-methylquinoline-8-carboxamide;(2,3-Dimethylbenzylamino)-2-methylquinoline-8-carboxamidetrifluoroacetate;4-{[(2,3-Dichlorophenyl)methyl]amino}-2-methyl-8-quinolinecarboxamide;4-(2,4-Dimethylbenzylamino)-2-methylquinoline-8-carboxamidetrifluoroacetate;4-(2,4-Dichlorobenzylamino)-2-methylquinoline-8-carboxamide(1s);4-(2,5-Dimethylbenzylamino)-2-methylquinoline-8-carboxamide;2-Methyl-4-(2-methylbenzylamino)quinoline-8-carboxamide;4-(2,6-Dichlorobenzylamino)-2-methylquinoline-8-carboxamide;4-(3,4-Dimethylbenzylamino)-2-methylquinoline-8-carboxamide;4-(3,4-Dichlorobenzylamino)-2-methylquinoline-8-carboxamideHydrochloride;4-(3,5-Dimethylbenzylamino)-2-methylquinoline-8-carboxamide;4-(3,5-Dichlorobenzylamino)-2-methylquinoline-8-carboxamide;4-(3-Chloro-2-fluorobenzylamino)-2-methylquinoline-8-carboxamide;4-(3-Chloro-2-methylbenzylamino)-2-methylquinoline-8-carboxamide;4-(2-Fluoro-3-(trifluoromethyl)benzylamino)-2-methylquinoline-8-carboxamide;2-Methyl-4-(naphthalen-1-ylmethylamino)quinoline-8-carboxamide;4-(2-Chloro-3,6-difluorobenzylamino)-2-methylquinoline-8-carboxamide;4-(2-Chloro-6-fluorobenzylamino)-2-methylquinoline-8-carboxamide;4-(2-Chloro-6-methylbenzylamino)-2-methylquinoline-8-carboxamide;4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-methylquinoline-8-carboxamide;2-Methyl-4-{[(2,3,6-trichlorophenyl)methyl]amino}-8-quinolinecarboxamide;4-{[(3-Chloro-2,6-difluorophenyl)methyl]amino}-2-methyl-8-quinolinecarboxamide;4-(2-Chloro-3,6-difluorobenzylamino)-2-methylquinoline-8-carboxamide;4-{[(3,6-Dichloro-2-fluorophenyl)methyl]amino}-2-methyl-8-quinolinecarboxamide;4-{[(2,3-Dichloro-6-fluorophenyl)methyl]amino}-2-methyl-8-quinolinecarboxamide;4-{[(2-Chloro-6-fluoro-3-methylphenyl)methyl]amino}-2-methyl-8-quinolinecarboxamide;2-Methyl-4-({[3-(trifluoromethyl)-2-pyridinyl]methyl}-amino)-8-quinolinecarboxamide;2-Methyl-4-({[4-(trifluoromethyl)-3-pyridinyl]methyl}-amino)-8-quinolinecarboxamide;4-{[(3-Chloro-4-pyridinyl)methyl]amino}-2-methyl-8-quinolinecarboxamide;2-Methyl-4-({[2-(trifluoromethyl)-3-pyridinyl]methyl}-amino)-8-quinolinecarboxamide;4-{[(3-Chloro-2-thienyl)methyl]amino}-2-methyl-8-quinolinecarboxamide;4-{[(3,5-Dimethyl-4-isoxazolyl)methyl]amino}-2-methyl-8-quinolinecarboxamide;4-[(Cyclohexyl methyl )amino]-2-methyl-8-quinolinecarboxamide;4-{[(1-Acetyl-4-piperidinyl)methyl]amino}-2-methyl-8-quinolinecarboxamide;2-Methyl-4-{[(1-methyl-4-piperidinyl)methyl]amino}-8-quinolinecarboxamide;2-Methyl-4-{[(1R)-1-(2-methylphenyl)ethyl]amino}-8-quinolinecarboxamide;4-{[(1S)-1-(2,6-Dimethylphenyl)ethyl]amino}-2-methyl-8-quinolinecarboxamide;2-Methyl-4-[(1R)-1,2,3,4-tetrahydro-1-naphthalenylamino]-8-quinolinecarboxamide;4-((2,6-Dichlorobenzyl)(methyl)amino)-2-methylquinoline8-carboxamide;4-(2,6-Dichlorobenzamido)-2-methylquinoline-8-carboxamide;4-((2,6-Dichlorobenzyl)oxy)-2-methylquinoline-8-carboxamide;4-((2,6-Dichlorobenzyl)thio)-2-methylquinoline-8-carboxamide;6-Fluoro-2-methyl-4-((2,3,6-trichlorobenzyl)amino)quinoline8-carboxamide;4-{[(2,6-Dimethylphenyl)methyl]amino}-2,6-dimethyl-8-quinolinecarboxamide;6-Bromo-4-((2,6-dimethylbenzyl)amino)-2-methylquinoline8-carboxamide;4-{[(2,6-Dimethylphenyl)methyl]amino}-2-methyl-6-phenyl8-quinolinecarboxamide;N-[(2,3-Dichlorophenyl)methyl]-2-methyl-4-quinolinamine;8-Bromo-N-[(2,3-dichlorophenyl)methyl]-2-methyl-4-quinolinamine;4-{[(2,3-Dichlorophenyl)methyl]amino}-N,2-dimethyl-8-quinolinecarboxamide;4-{[(2,3-Dichlorophenyl)methyl]amino}-N,N,2-trimethyl-8-quinolinecarboxamide;Methyl 4-{[(2,3-Dichlorophenyl)methyl]amino}-2-methyl-8-quinolinecarboxylate;4-{[(2,3-Dichlorophenyl)methyl]amino}-2-methyl-8-quinolinecarboxylicacid;(4-{[(2,3-Dichlorophenyl)methyl]amino}-2-methyl-8-quinolinyl)methanol;8-(Aminomethyl)-N-[(2,3-dichlorophenyl)methyl]-2-methyl4-quinolinamine;4-{[(2,3-Dichlorophenyl)methyl]amino}-2-methyl-8-quinolinecarbonitrile;4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)-2-methylquinoline-8-carboxamide;2-(((1H-pyrazol-4-yl)methyl)amino)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)quinoline-8-carboxamide;2-(((1H-pyrazol-4-yl)methyl)amino)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(((1H-pyrazol-3-yl)methyl)amino)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(((1 H-1 ,2,4-triazol-3-yl)methyl)amino)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(((1H-imidazol-4-yl)methyl)amino)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(((1H-imidazol-2-yl)methyl)amino)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(((1H-Tetrazol-5-yl)methyl)amino)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide trifluoroacetate;4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-((oxazol-2-ylmethyl)amino)quinazoline-8- carboxamide;4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-((oxazol-5-ylmethyl)amino)quinazoline-8- carboxamide;4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-((isoxazol-3-ylmethyl)amino)quinazoline- 8-carboxamide;2-(((1H-Pyrazol-5-yl)methyl)(methyl)amino)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-(((3-methyl1H-pyrazol-4- yl)methyl)amino)quinazoline-8-carboxamide;2-(4,6-Dihydropyrrolo[3,4-c]pyrazol-5(1H)-yl)-4-({[2-fluoro-6-(trifluoromethyl)phenyl]methyl}amino)-8-quinazolinecarboxamide;2-(6,7-Dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(4,5-Dihydro-1H-pyrazolo[3,4-c]pyridin-6(7H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(5,6-Dihydropyrazolo[3,4-c]azepin-7(1H,4H,8H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;(R)-4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-(6-methylpyrrolo[3,4-c]pyrazol- 5(1H,4H,6H)-yl)quinazoline-8-carboxamide;(S)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)-2-(6-methylpyrrolo[3,4-c]pyrazol- 5(1H,4H,6H)-yl)quinazoline-8-carboxamide;4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-(1 -methyl pyrrolo[3,4-c]pyrazol- 5(1H,4H,6H)-yl)quinazoline-8-carboxamide;4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-(2-methylpyrrolo[3,4-c]pyrazol- 5(2H,4H,6H)-yl)quinazoline-8-carboxamide;4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-(3-methylpyrrolo[3,4-c]pyrazol- 5(1H,4H,6H)-yl)quinazoline-8-carboxamide;(S)-4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-(4-methylpyrrolo[3,4-c]pyrazol- 5(1H,4H,6H)-yl)quinazoline-8-carboxamide;(R)-4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-(4-methylpyrrolo[3,4-c]pyrazol- 5(1H,4H,6H)-yl)quinazoline-8-carboxamide;(R)-2-(6-Ethylpyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;(S)-2-(6-ethylpyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(3-Ethylpyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-4-((2-fluoro6-(trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-(3-(trifluoromethyl)pyrrolo[3,4-c]pyrazol- 5(1H,4H,6H)-yl)quinazoline8-carboxamide;4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-(3-oxo-2,3-dihydropyrrolo[3,4-c]pyrazol- 5(1H,4H,6H)-yl)quinazoline-8-carboxamide, trifluoroacetic acid salt;2-(3-Aminopyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(3-Carbamoylpyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;(S)-4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-(3-(1-hydroxyethyl)pyrrolo[3,4- c]pyrazol-5(1H,4H,6H)-yl)quinazoline-8-carboxamide trifluoroacetate;(R)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)-2-(3-(1-hydroxyethyl)pyrrolo[3,4- c]pyrazol-5(1H,4H,6H)-yl)quinazoline-8-carboxamide trifluoroacetate;(R)-2-(3,6-Dimethylpyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;(S)-2-(3,6-Dimethylpyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;(R)-2-(3-Amino-6-methylpyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;(S)-2-(3-Amino-6-methylpyrrolo[3,4-c]pyrazol5(1H,4H,6H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(3-Amino-6,6-dimethylpyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(3’-Amino- H-spiro[cyclopropane-1,6’-pyrrolo[3,4-c]pyrazol]-5’(4’H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(3’-Amino- H-spiro[cyclobutane-1,6’-pyrrolo[3,4-c]pyrazol]-5’(4’H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(3’-Amino- H-spiro[cyclopentane-1 ,6’-pyrrolo[3,4-c]pyrazol]-5’(4’H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;N-((1 r,4r)-4-(2-Hydroxy-2-methyl propoxy )cyclohexyl)-5-(1 H-imidazol-1-yl)-1 H-indole-7- carboxamide;N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2-(thiazol-5-yl)-6-(1 H-imidazol-1 - yl)isonicotinamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2,6-di(thiazol-5-yl)isonicotinamide;N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2-(1 -methyl-1 H-pyrazol-4-yl)-6-(thiazol-5- yl)isonicotinamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2-(thiazol-5-yl)-6- (trifluoromethyl)isonicotinamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2,6-di(thiazol-5-yl)pyrimidine-4-carboxamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(methylthio)-2-(thiazol-5-yl)pyrimidine-4- carboxamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(methylthio)-2-(thiazol-5-yl)pyrimidine-4- carboxamide;4-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(thiazol-5- yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)picol inamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-4-(1 -methyl-1 H-pyrazol- 4-yl)picolinamide;6-(1 H-imidazol-1 -yl )-4-( 1 -isopropyl-1 H-pyrazol-4-yl)-N-((1 r,4r)-4-(2- methoxyethoxy )cyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl )-4-( 1 -isopropyl-1 H-pyrazol-4-yl)-N-((1 r,4r)-4-(2- methoxyethoxy)cyclohexyl)picolinamide;4-amino-6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)picolinamide;4,6-di(1 H-imidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-4-(thiazol-5- yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-4-(thiazol-5- yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-4- (trifluoromethyl)picolinamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-4- (trifluoromethyl)picolinamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)isonicotinamide;2, 6-di(1 H-imidazol-1 -yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)isonicotinamide;2, 6-di(1 H-imidazol-1 -yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)isonicotinamide;2-(1-ethyl-1H-pyrazol-4-yl)-6-(1 H-imidazol-1 -yl)-N-((1r, 4r)-4-(2- methoxyethoxy )cyclohexyl)isonicotinamide;2-(1 H-imidazol-1 -yl )-6-( 1 -isopropyl-;H-pyrazol-4-yl)-N-((1 r,4r)-4-(2- methoxyethoxy)cyclohexyl ) ison icoti na m ide ;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(1 -methyl-1 H-pyrazol-3-yl)isonicotinamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(1 -methyl-1 H-pyrazol-4-yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy )cyclohexyl)pyrimidine-4- carboxamide;6-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-4-methylpicolinamide;4-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(1 -methyl 1 H-pyrazol-4- yl)picolinamide;N-((1r,4r)-4-hydroxycyclohexyl)-6-(1 H-imidazol-1 -yl)picolinamide;N-cyclohexyl-6-(1 H-imidazol-1 -yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)picol inamide;N-((1r,4r)-4-hydroxycyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-methylpyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(trifl uoro methyl ) pyri m id i ne-4-carboxa m ide ;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-4- (methylthio)picolinamide;4-(1-Hydroxyethyl)-6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-(2- methoxyethoxy)cyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-4- (methylsulfonyl)picolinamide;4-(2-Hydroxypropan-2-yl)-6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2- methoxyethoxy)cyclohexyl)picolinamide;N-((1 r,4r)-4-(difluoromethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;N-((1 r,4r)-4-(difluoromethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6- methyl pyri midi ne-4- carboxamide;4-Cyano-6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2- methoxyethoxy )cyclohexyl)picolinamide;N-((1 r,4r)-4-(2-hydroxyethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methylpyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-methylpyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-methyl isonicotinamide;6-cyano-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)pyrimidine-4,6- dicarboxamide;6-(hydroxymethyl)-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2- methoxyethoxy)cyclohexyl ) pyri m id i ne-4-carboxa m ide ;2-(1 H-imidazol-1 -yl-d3)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-methylpyrimidine-4- carboxamide;6-(fluoromethyl)-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2- methoxyethoxy)cyclohexyl ) pyri m id i ne-4-carboxa m ide ;6-(Difluoromethyl)-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2- methoxyethoxy)cyclohexyl ) pyri m id i ne-4-carboxa m ide ;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxy-4-methylcyclohexyl)pyrimidine-4-carboxamide;N-((1 s,4s)-4-hydroxy-4-methylcyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;N-((1 s,4s)-4-hydroxy-4-methylcyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;6-cyclopropyl-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)pyrimidine- 4-carboxamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-4-vinylpicolinamide;N-((1 r,4r)-4-ethoxycyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;4-(difluoromethyl)-6-(1 H-imidazol-1 -yl)-N-((1r, 4r)-4-(2- methoxyethoxy)cyclohexyl)picolinamide;2-(1 H-imidazol-1 -yl)-N-((1s, 4s)-4-(2-methoxyethoxy)cyclohexyl)-6-methylpyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxy-2-methyl propoxy )cyclohexyl)-6- methylpyrimidine-4-carboxamide;6-(1 H-imidazol-1 -yl)-4-methoxy-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)picolinamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrimidine-4-carboxamide;N-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,3r)-3-(2-methoxyethoxy)cyclobutyl)pyrimidine-4-carboxamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-5-(thiazol-5-yl)-1 H-indole-7-carboxamide;N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-5-(1 H-pyrazol-1-yl)-1 H-indole-7-carboxamide;N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-5-(1 H-1 ,2,4-triazol-1 -yl)-1 Hindole-7- carboxamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-5-(5H-tetrazol-5-yl)-1 H-indole7-carboxamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-5-(thiazol-4-yl)-1 H-indole-7-carboxamide;5-(1 H-imidazol-2-yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 H-indole-7- carboxamide;N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-5-(1 H-pyrazol-4-yl)-1 H-indole-7-carboxamide;-(1 -hydroxyethyl )-5-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1H- indole-7-carboxamide; -((S)-1-hydroxyethyl)-5-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)- 1 H-indole-7-carboxamide; -((R)-l-hydroxyethyl)-5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)- 1 H-indole-7-carboxamide; -(1 H-imidazol-1 -yl )-7-(((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)carbamoyl)-1 H-indole-3- carboxylic acid; -(1 H-imidazol-1 -yl)-N7-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-N3-methyl-1 H-indole- 3,7-dicarboxamide; -(1 H-imidazol-1 -yl)-N7-((1r, 4r)-4-(2-methoxyethoxy)cyclohexyl)-N3,N3-dimethyl-1H- indole-3,7-dicarboxamide; -(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-3-nitro-1 H-indole-7- carboxamide; -formyl-5-(1 H-imidazol-1 -yl)-N-((1r, 4r)-4-(2-methoxyethoxy)cyclohexyl)-1H-indole-7- carboxamide; -((dimethylamino)methyl)-5-(1 H-imidazol-1 -yl)-N-((1r, 4r)-4-(2- methoxyethoxy)cyclohexyl)-1 H-indole-7-carboxamide; -(aminomethyl)-5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 H- indole-7-carboxamide; -(hydroxymethyl)-5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 H- indole-7-carboxamide; -(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-3-(trifluoromethyl)-1 H- indole-7-carboxamide; -cyano-N-((1 r,4r)-4-(2-methoxyethoxy )cyclohexyl)-5-(thiazol-5-yl)-1 H-indole-7- carboxamide; -cyano-5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 H-indole-7- carboxamide; -(1 H-imidazol-1 -yl)-3-iodo-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 H-indole-7- carboxamide;5-(1 H-imidazol-1 -yl)-N7-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 Hindole-3,7- dicarboxamide;N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-(2-fluoro-6-(trifluoromethyl)benzyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-(2-(methylsulfonyl)ethyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((tetrahydro-2H-pyran-4-yl)methyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1r,3r)-3-(2-methoxyethoxy)cyclobutyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1R,3R)-3-hydroxycyclopentyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1 s,3s)-3-(2-methoxyethoxy )cyclobutyl)-6-(thiazol-5-yl)-1 H-indole-4-carboxamide;N-(4-morpholinobenzyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-(T rans-3-(2-methoxyethoxy )cyclopentyl)-6-(thiazol-5-yl)-1 H-indole-4-carboxamide;N-(piperidin-4-yl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide hydrochloride;N-(3-hydroxy-3-methylcyclobutyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1r,4r)-4-(3-methoxypropoxy)cyclohexyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-(1-(2-fluorophenyl)ethyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1R,2S)-2-methylcyclohexyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1r,4r)-4-hydroxycyclohexyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-(1 -methoxy-2-methyl propan-2-yl)-6-(thiazol-5-yl)-1 H-indole-4-carboxamide;N-(2-hydroxy-2-methylpropyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-(adamantan-1 -yl )-6-(th iazol -5-yl )- 1 H-indole-4-carboxamide;N-(tetrahydro-2H-pyran-4-yl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1r,3r)-3-hydroxycyclobutyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1 s,4s)-4-(2-methoxyethoxy )cyclohexyl)-6-(thiazol-5-yl)-1 H-indole-4-carboxamide;Methyl-5-(1 H-imidazol-1 -yl )-7-(((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)carbamoyl)-1 H- indole-3-carboxylate;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1-(oxetan-3-ylmethyl)-6-(thiazol-5-yl)-1 H- indole-4-carboxamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1-methyl-6-(thiazol-5-yl)-1H-indole-4- carboxamide;1-isopropyl-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(thiazol-5-yl)-1H-indole-4- carboxamide;1-(2-hydroxy-2-methyl propyl )-N-((1r, 4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(thiazol-5-yl)- 1 H-indole-4-carboxamide;5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 -methyl-1 H-indole-7- carboxamide;7-fluoro-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(thiazol-5-yl)-1 H-indole-4- carboxamide;3-cyano-6-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 H-indole-4- carboxamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-3-methyl-6-(thiazol-5-yl)-1H-indole-4- carboxamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(thiazol-5-yl)-1 H-pyrrolo[2,3-b]pyridine-4- carboxamide;5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 Hpyrrolo[2,3-c]pyridine-7-carboxamide;N-((1 r,4r)-4-(2-methoxyethoxy )cyclohexyl)-5-(thiazol-5-yl)-1 H-pyrrolo[3,2-b]pyridine-7- carboxamide;4,6-di(1 H-imidazol-1-yl)-N-((1r,4r)-4-methoxycyclohexyl)picolinamide;6-chloro-4-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)picolinamide;4-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-methoxycyclohexyl)-6-oxo-1 ,6-dihydropyridine-2- carboxamide;6-(1 H-imidazol-1 -yl)-4-methoxy-N-((1 r,4r)-4-methoxycyclohexyl)picolinamide;4-hydroxy-6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)picolinamide;2-acetamido-N-((1r,4r)-4-methoxycyclohexyl)-5-(thiazol-5-yl)benzamide;2-amino-N-((1r,4r)-4-methoxycyclohexyl)-5-(thiazol-5-yl)benzamide;2-fluoro-N-((1r,4r)-4-methoxycyclohexyl)-3-(thiazol-5-yl)benzamide;N-((1r,4r)-4-methoxycyclohexyl)-6-(thiazol-5-yl)pyrazine-2-carboxamide;3-amino-6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)pyridazine-4-carboxamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrazine-2-carboxamide;N-((1r,4r)-4-methoxycyclohexyl)-6-(thiazol-5-yl)picolinamide;N-((1r,4r)-4-methoxycyclohexyl)-6-(1 H-pyrazol-5-yl)pyrazine-2-carboxamide;N-((1r,4r)-4-methoxycyclohexyl)-6-(1 H-pyrazol-4-yl)pyrazine-2-carboxamide;6-(isoxazol-4-yl)-N-((1r,4r)-4-methoxycyclohexyl)pyrazine-2-carboxamide;N-((1r,4r)-4-methoxycyclohexyl)-6-(pyridin-4-yl)pyrazine-2-carboxamide;6-(isoxazol-5-yl)-N-((1r,4r)-4-methoxycyclohexyl)picolinamide;N-((1r,4r)-4-methoxycyclohexyl)-6-(4H-1 ,2,4-triazol-4-yl)pyrazine-2-carboxamide;N-((1r,4r)-4-methoxycyclohexyl)-6-(1 ,3,4-oxadiazol-2-yl)pyrazine-2-carboxamide;5-amino-6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)picolinamide;2-amino-6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)pyrimidine-4-carboxamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-2-(methylamino)pyrimidine-4- carboxamide;6-(dimethylamino)-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-6-(methylamino)pyrimidine-4- carboxamide;6-amino-2-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1r, 4r)-4-methoxycyclohexyl)-6-(piperidin-1-yl)pyrimidine-4- carboxamide;3-amino-N-((1r,4r)-4-methoxycyclohexyl)-6-(thiazol-5-yl)pyrazine-2-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyridazine-3-carboxamide;N-cyclohexyl-6-(1H-imidazol-1-yl)pyrazine-2-carboxamide;6-(1 H-imidazol-1 -yl)-N-isopropylpyrazine-2-carboxamide;6-(1 H-imidazol-1 -yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazine-2-carboxamide;6-(1 H-imidazol-1 -yl)-N-(piperidin-4-yl)pyrazine-2-carboxamide;N-(tert-butyl)-6-(1 H-imidazol-1 -yl)pyrazine-2-carboxamide;6-(1 H-imidazol-1 -yl)-N-phenylpyrazine-2-carboxamide;6-(1 H-imidazol-1 -yl)-N-(1-methylpiperidin-4-yl)pyrazine-2-carboxamide;N-(cyclohexylmethyl)-6-(1 H-imidazol-1 -yl)pyrazine-2-carboxamide;N-benzyl-6-(1 H-imidazol-1 -yl)pyrazine-2-carboxamide;N-(1-cyclohexylethyl)-6-(1 H-imidazol-1 -yl)pyrazine-2-carboxamide;N-(1-acetylpiperidin-4-yl)-6-(1H-imidazol-1-yl)pyrazine-2-carboxamide;3-amino-6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)pyrazine-2-carboxamide;3-amino-N-cyclohexyl-6-(1 H-imidazol-1-yl)pyrazine-2-carboxamide;3-(dimethylamino)-6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrazine-2- carboxamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-3-(methylamino)pyrazine-2- carboxamide;4-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-6-methylpicolinamide;4-chloro-6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-4-methylpicolinamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-4-(trifluoromethyl)picolinamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)nicotinamide;2-amino-5-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)nicotinamide;3-amino-6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)picolinamide;3-amino-N-cyclohexyl-6-(1 H-imidazol-1 -yl)picolinamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)isonicotinamide;4-(1H-imidazol-1-yl)-N-((1r,4r)-4-methoxycyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrimidine-4-carboxamide;N-cyclooctyl-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)pyrimidine-4-carboxamide;3-hydroxy-6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrazine-2-carboxamide;2-hydroxy-5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)nicotinamide;5-amino-2-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)isonicotinamide;N-((1 r,4r)-4-methoxycyclohexyl)-6-(1 H-1 ,2,4-triazol-1 -yl)pyrazine-2-carboxamide;3-hydroxy-6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)picolinamide;N-cyclohexyl-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;4-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrimidine-2-carboxamide;6-(1 H-imidazol-1 -yl)-5-methoxy-N-((1 r,4r)-4-methoxycyclohexyl)picolinamide;3-chloro-6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-5-methylpicolinamide;5-chloro-6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)picolinamide;N-cyclohexyl-6-(4-methyl-1H-imidazol-1-yl)pyrazine-2-carboxamide;N-cyclohexyl-6-(5-methyl-1H-imidazol-1-yl)pyrazine-2-carboxamide;N-cyclohexyl-6-(2-methyl-1H-imidazol-1-yl)pyrazine-2-carboxamide;2-(1 H-imidazol-1 -yl)-N-phenylpyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(o-tolyl)pyrimidine-4-carboxamide;N-(2-fluorophenyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide;N-(2-chlorophenyl)-2-(1H-imidazol-1-yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(2-methoxyphenyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(p-tolyl)pyrimidine-4-carboxamide;N-(4-fluorophenyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide;N-(4-chlorophenyl)-2-(1H-imidazol-1-yl)pyrimidine-4-carboxamide;2-(1H-imidazol-1-yl)-N-(4-(trifluoromethyl)phenyl)pyrimidine-4-carboxamide;N-(4-cyanophenyl)-2-(1H-imidazol-1-yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(m-tolyl)pyrimidine-4-carboxamide;N-(3-fluorophenyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide;N-(3-chlorophenyl)-2-(1H-imidazol-1-yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(thiazol-5-yl)pyrimidine-4-carboxamide;N-cyclopentyl-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;N-cycloheptyl-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-6-methylpyrimidine-4-carboxamide;N-((1 r,4r)-4-methoxycyclohexyl)-2-(1 H-pyrazol-1 -yl)pyrimidine-4-carboxamide;N-(3-fluorophenyl)-2-(1 H-imidazol-1 -yl)-6-(piperidin-1-yl)pyrimidine-4-carboxamide;N-(3-fluorophenyl)-2-(1 H-pyrazol-1 -yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;6-cyclobutoxy-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-6-methoxy-N-((1 r,4r)-4-methoxycyclohexyl)pyrimidine-4- carboxamide;6-cyano-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)pyrimidine-4- carboxamide;N-(4,4-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methylcyclohexyl)pyrimidine-4-carboxamide;N-(4,4-difluorocyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(pyridin-4-yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(pyridin-2-yl)pyrimidine-4-carboxamide;2-(1H-imidazol-1-yl)-N-((1s,4s)-4-methylcyclohexyl)pyrimidine-4-carboxamide;N-(3-fluorophenyl)-2-(1 H-imidazol-1-yl)-6-morpholinopyrimidine-4-carboxamide;N-(3-fluorophenyl)-2-(1 H-imidazol-1-yl)-5-(piperidin-1-yl)pyrimidine-4-carboxamide;N-(3-fluorophenyl)-2-(1 H-pyrazol-5-yl)pyrimidine-4-carboxamide;N-(3-fluorophenyl)-2-(1 H-imidazol-1 -yl)-N-methyl-6-(piperidin-1 -yl)pyrimidine-4- carboxamide;N-(2,6-difluorophenyl)-2-(1 H-imidazol-1 -yl )-6-(pi peridin-1 -yl)pyrimidine-4-carboxamide;N-benzyl-2-(1H-imidazol-1-yl)-6-(piperidin-1-yl)pyrimidine-4-carboxamide;N-(3-fluorophenyl)-2-(1 H-imidazol-1-yl)-6-(pyrrolidin-1-yl)pyrimidine-4-carboxamide;6-cyclobutoxy-N-(3-fluorophenyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide;N-(3-fluorophenyl)-2-(1 H-imidazol-1-yl)-6-(oxetan-3-yloxy)pyrimidine-4-carboxamide;N-(3-fluorophenyl)-2-(1 H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(3-chlorophenyl)-2-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(3,4-difluorophenyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;N-(3,5-difluorophenyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;N-(4-chloro-3-fluorophenyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;4-(4,4-dimethylpiperidin-1-yl)-N-(3-fluorophenyl)-6-(1 H-imidazol-1 -yl)picolinamide;N-(3-fluorophenyl)-6-(1 H-imidazol-1 -yl)-4-(piperidin-1-yl)picolinamide;N-cyclohexyl-6-(1 H-imidazol-1 -yl)-4-(piperidin-1-yl)picolinamide;N-(3-fluorophenyl)-6-(1 H-imidazol-1-yl)-4-isopropylpicolinamide;N-(3-fluorophenyl)-2-(1 H-imidazol-1-yl)-6-isopropylpyrimidine-4-carboxamide;N-(3-fluorophenyl)-6-(1 H-imidazol-1-yl)-4-(trifluoromethyl)picolinamide;N-(3,4-difluorophenyl)-2-(1 H-imidazol-1 -yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(2,5-difluorophenyl)-2-(1 H-imidazol-1 -yl )-6-(pi peridin-1 -yl)pyrimidine-4-carboxamide;N-(2-chloro-5-fluorophenyl)-2-(1 H-imidazol-1 -yl )-6-( piperidin-1 -yl)pyrimidine-4- carboxamide;N-(5-fluoro-2-methylphenyl)-2-(1 H-imidazol-1 -yl )-6-(pi peridin-1 -yl)pyrimidine-4- carboxamide;N-(4,4-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-(1-methylcyclohexyl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-cyclohexyl-2-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(tert-butyl)-2-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(4,4-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl )-6-( piperidin-1 -yl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-(1-methylcyclohexyl)-6-(piperidin-1-yl)pyrimidine-4-carboxamide;N-cyclohexyl-2-(1 H-imidazol-1 -yl)-6-(piperidin-1-yl)pyrimidine-4-carboxamide;N-(tert-butyl)-2-(1 H-imidazol-1 -yl)-6-(piperidin-1-yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-methylcyclohexyl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-methylcyclohexyl)-6-(piperidin-1 -yl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-methylcyclohexyl)-6-morpholinopyrimidine-4- carboxamide;6-cyclobutoxy-2-(1 H-imidazol-1 -yl )-N-((1 r,4r)-4-methylcyclohexyl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-methylcyclohexyl)-6-(oxetan-3-yloxy)pyrimidine-4- carboxamide;6-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-methoxycyclohexyl)-3-(trifluoromethyl)picolinamide;6-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-methoxycyclohexyl)-5-(trifluoromethyl)picolinamide;N-((1 r,4r)-4-methoxycyclohexyl)-2-(4-(trifluoromethyl)-1 H-imidazol-1 -yl)pyrimidine-4- carboxamide;N-((1 r,4r)-4-methoxycyclohexyl)-2-(2-(trifluoromethyl)-1 H-imidazol-1 -yl)pyrimidine-4- carboxamide;N-((1 r,4r)-4-methoxycyclohexyl)-6-(4-(trifluoromethyl)-1 H-imidazol-1 -yl)picolinamide;N-((1 r,4r)-4-methoxycyclohexyl)-6-(2-(trifluoromethyl)-1 H-imidazol-1 -yl)picolinamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6- (trifl uoro methyl ) pyri m id i ne-4-carboxa m ide ;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methylcyclohexyl)-4-(trifluoromethyl)picolinamide;N-(3-fluorophenyl)-6-(1 H-imidazol-1-yl)-3-(trifluoromethyl)picolinamide;N-(3-fluorophenyl)-6-(1 H-imidazol-1-yl)-5-(trifluoromethyl)picolinamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-5-(trifluoromethyl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-(piperidin-4-yl)-6-(trifluoromethyl)pyrimidine-4- carboxamidehydrochloride;2-(1 H-imidazol-1 -yl)-N-(tetrahydro-2H-pyran-4-yl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;N-(6-cyanopyridin-3-yl)-2-(1 H-imidazol-1 -yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(4-cyanophenyl)-2-(1 H-imidazol-1 -yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(5-fluoropyridin-3-yl)-2-(1 H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(pyridin-4-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(5-cyanopyridin-3-yl)-2-(1 H-imidazol-1 -yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(pyrimidin-5-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(pyridazin-4-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(4-fluorophenyl)-2-(1 H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(3,4-difluorophenyl)-2-(1 H-imidazol-1 -yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(3,5-difluorophenyl)-2-(1 H-imidazol-1 -yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(3-fluoro-5-(piperazin-1 -yl)phenyl)-2-(1 H-imidazol-1 -yl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;N-(3-fluoro-5-morpholinophenyl)-2-(1 H-imidazol-1 -yl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-(3-morpholinophenyl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;(S)-N-(3-fluoro-5-(3-hydroxypyrrolidin-1-yl)phenyl)-2-(1 H-imidazol-1 -yl)-6-(trifl uoro methyl ) pyri m id i ne-4-carboxa m ide ;N-(3-fluoro-5-(2-methoxypropan-2-yl)phenyl)-2-(1 H-imidazol-1-yl)-6-(trifl uoro methyl ) pyri m id i ne-4-carboxa m ide ;N-(3-fluoro-4-(2-hydroxypropan-2-yl)phenyl)-2-(1H-imidazol-1-yl)-6-(trifl uoro methyl ) pyri m id i ne-4-carboxa m ide ;N-(3-(2-(dimethylamino)ethoxy)-5-fluorophenyl)-2-(1 H-imidazol-1 -yl)-6-(trifl uoro methyl ) pyri m id i ne-4-carboxa m ide ;N-(3-fluoro-5-(2-methoxyethoxy)phenyl)-2-(1 H-imidazol-1 -yl)-6-(trifl uoro methyl ) pyri m id i ne-4-carboxa m ide ;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-6-(pyridin-4-yl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-6-(2-(trifluoromethyl)pyridin-4- yl )pyri m id i ne-4-carboxa m ide ;6-cyano-N-(3-fluorophenyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide6-cyano-2-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)pyrimidine-4-carboxamide;6-cyano-N-(4-fluorophenyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide2-(1 H-imidazol-1 -yl)-N-(2-(2-methoxyethoxy)pyrimidin-5-yl)-6-(trifluoromethyl)pyrimidine- 4-carboxamide;6-cyano-2-(1 H-imidazol-1 -yl)-N-(pyrimidin-5-yl)pyrimidine-4-carboxamide;6-(1 H-imidazol-1 -yl)-N-(pyridin-4-yl)-4-(trifluoromethyl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)-4-(trifluoromethyl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(pyrimidin-5-yl)-4-(trifluoromethyl)picolinamide;N-(2-(2-hydroxyethoxy)pyrimidin-5-yl)-2-(1 H-imidazol-1 -yl)-6-(trifluoromethyl)pyrimidine- 4-carboxamide;2-((5-(2-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamido)pyrimidin-2- yl)oxy)aceticacid;N-(2-hydroxypyrimidin-5-yl)-2-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;N-cyclohexyl-4-oxo-2-(pyridin-4-yl)-3,4-dihydrothieno[3,2-d]pyrimidine-7-carboxamide;4-amino-N-cyclohexyl-2-(pyridin-4-yl)thieno[3,2-d]pyrimidine-7-carboxamide;N-((1S,2S)-1 -hydroxy-2, 3-dihydro-1H-inden-2-yl)-4-oxo-2-(pyridin-4-yl)-3, 4- dihydrothieno[3,4-d]pyrimidine-7-carboxamide;N-(2,3-dihydro-1H-inden-2-yl)-4-oxo-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4-d] pyrimidine- 7-carboxamide;4-oxo-2-(pyridin-4-yl)-N-((2R)-5-((tetrahydrofuran-3-yl)oxy)-2,3-dihydro-1H-inden-2-yl)- 3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxamide;N-cyclohexyl-4-oxo-2-(thiazol-5-yl)-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxamide;N-cyclohexyl-2-methyl-4-oxo-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxamide;N-cyclohexyl-4-oxo-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxamide;4-oxo-2-(pyridin-4-yl)-N-(tetrahydro-2H-pyran-4-yl)-3,4-dihydrothieno[3,4-d]pyrimidine-7- carboxamide;N-((1r,4r)-4-hydroxycyclohexyl)-4-oxo-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4-d]pyrimidine- 7-carboxamide;N-benzyl-4-oxo-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxamide;4-oxo-N-phenethyl-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxamide;4-oxo-N-(pyridin-3-ylmethyl)-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4-d]pyrimidine-7- carboxamide;N-(5-ethoxy-2,3-dihydro-1H-inden-2-yl)-4-oxo-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4- d]pyrimidine-7-carboxamide;N-cyclohexyl-4-oxo-2-phenyl-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxamide;N-cyclohexyl-4-oxo-2-(pyridin-3-yl)-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxamide;N-(1-cyclohexylethyl)-4-oxo-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4-d]pyrimidine-7- carboxamide;N-(bicyclo[2.2.2]octan-1-yl)-4-oxo-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4-d]pyrimidine-7- carboxamide;N-(1-cyclohexyl-2-hydroxyethyl)-4-oxo-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4- d]pyrimidine-7-carboxamide; methyl2-cyclohexyl-2-(4-oxo-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4-d]pyrimidine-7- carboxamido)acetate;N-cyclohexyl-5-(pyridin-4-yl)benzo[d]isoxazole-3-carboxamide;N-cyclohexyl-2-(pyridin-4-yl)-1H-indole-4-carboxamide;N-cyclohexyl-3-(pyridin-4-yl)-1H-indole-5-carboxamide;N-cyclohexyl-3-(pyridin-4-yl)-1H-indazole-5-carboxamide;N-((1r,4r)-4-methoxycyclohexyl)-3-(thiazol-5-yl)-1H-indazole-5-carboxamide;N-cyclohexyl-2-(pyridin-4-yl)-1H-benzo[d]imidazole-4-carboxamide;N-cyclohexyl-8-(pyridin-4-yl)-9H-purin-6-amine;N-cyclohexyl-7-(pyridin-4-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amine;N-cyclohexyl-7-(thiazol-5-yl)thieno[3,2-d]pyrimidin-2-amine;N-cyclohexyl-6-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;N-cyclohexyl-6-(thiazol-5-yl)thieno[2,3-d]pyrimidin-4-amine;2-(cyclohexylamino)-7-(1H-imidazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one;N-cyclohexyl-5-(thiazol-5-yl)-1H-indazol-3-amine;1-(3-(cyclohexylamino)-5-(thiazol-5-yl)-1H-indazol-1-yl)ethanone;N-cyclohexyl-1-methyl-5-(thiazol-5-yl)-1H-indazol-3-amine;N-cyclohexyl-5-(pyridin-4-yl)-1H-indazol-3-amine;N-cyclohexyl-5-(pyrazin-2-yl)-1H-indazol-3-amine;N-(cyclohexylmethyl)-5-(thiazol-5-yl)-1H-indazol-3-amine;N-cyclohexyl-7-(thiazol-5-yl)benzo[d]oxazol-2-amine;4-(((1r,4r)-4-methoxycyclohexyl)amino)-1-methyl-6-(1H-pyrazol-4-yl)quinolin-2(1H)-one;N-(5-(thiazol-5-yl)-1 H-indazol-3-yl)cyclohexanecarboxamide;N-cyclohexyl-2-oxo-3-(pyridin-4-yl)-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide;N-(1-(pyridin-4-yl)-1 H-benzo[d]imidazol-6-yl)cyclohexanecarboxamide; methyl 5-(6-(1 H-imidazol-1-yl)picolinamido)picolinate;5-(6-(1H-imidazol-1-yl)picolinamido)-N-methylpicolinamide;N-(6-carbamoylpyridin-3-yl)-6-(1H-imidazol-1-yl)picolinamide;N-(2-cyano-6-methylpyridin-4-yl)-6-(1H-imidazol-1-yl)picolinamide;N-(2,6-difluoropyridin-4-yl)-6-(1 H-imidazol-1-yl)picolinamide; ethyl 4-(6-(1 H-imidazol-1-yl)picolinamido)picolinate;N-(2,6-dimethylpyridin-4-yl)-6-(1 H-imidazol-1-yl)picolinamide;N-(2-fluoropyridin-4-yl)-6-(1 H-imidazol-1-yl)picolinamide;6-(1H-imidazol-1-yl)-N-(6-(trifluoromethyl)pyridin-3-yl)picolinamide;6-(1H-imidazol-1-yl)-N-(2-((2-methoxyethyl)amino)pyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(2-methylpyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(2-methoxypyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(pyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(6-methylpyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(6-(N-methylacetamido)pyridin-3-yl)picolinamide;N-(6-acetamidopyridin-3-yl)-6-(1 H-imidazol-1 -yl)picolinamide;N-(2-carbamoylpyridin-4-yl)-6-(1 H-imidazol-1 -yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(6-methoxypyridin-3-yl)picolinamide;N-(6-(N-ethylacetamido)pyridin-3-yl)-6-(1 H-imidazol-1 -yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)picolinamide;5-(6-(1 H-imidazol-1 -yl)picolinamido)picolinic acid;N-(6-fluoropyridin-3-yl)-6-(1 H-imidazol-1 -yl)picolinamide;4-(6-(1H-imidazol-1-yl)picolinamido)-N-methylpicolinamide;6-(1 H-imidazol-1 -yl)-N-(pyrimidin-4-yl)picolinamide;6-(1H-imidazol-1-yl)-N-(pyridin-2-yl)picolinamide;6-(5-methyl-1 H-imidazol-1 -yl)-N-(pyridin-3-yl)picolinamide; methyl 5-(6-(1 H-imidazol-1 -yl)picolinamido)picolinate;6-(1 H-imidazol-1 -yl)-N-(2-(trifluoromethyl)pyridin-4-yl)picolinamide;4-(benzyloxy)-6-(1 H-imidazol-1 -yl)-N-(2-(trifluoromethyl)pyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-((tetrahydro-2H-pyran-4-yl)methoxy)-N-(2-(trifluoromethyl)pyridin- 4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-(2-methoxyethoxy)-N-(2-(trifluoromethyl)pyridin-4-yl)picolinamide;4-cyclopropoxy-6-(1 H-imidazol-1-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)picolinamide;4-(2-(dimethylamino)ethoxy)-6-(1 H-imidazol-1 -yl)-N-(2-(trifluoromethyl)pyridin-4- yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-((3-methyloxetan-3-yl)oxy)-N-(2-(trifluoromethyl)pyridin-4- yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-methoxy-N-(2-(trifluoromethyl)pyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-methoxy-N-(pyridin-3-yl)picolinamide;2-(1 H-imidazol-1 -yl)-6-methoxy-N-(2-(trifluoromethyl)pyridin-4-yl)pyrimidine-4- carboxamide;6-ethoxy-2-(1H-imidazol-1-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-6-(2-methoxyethoxy)-N-(2-(trifluoromethyl)pyridin-4-yl)pyrimidine-4- carboxamide;6-cyclopropoxy-2-(1 H-imidazol-1-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-6-((3-methyloxetan-3-yl)oxy)-N-(2-(trifluoromethyl)pyridin-4- yl )pyri m id i ne-4-carboxa m ide ;6-(1-methyl-1H-imidazol-5-yl)-N-(pyridin-3-yl)picolinamide;6-(1-methyl-1H-imidazol-5-yl)-N-(6-(trifluoromethyl)pyridin-3-yl)picolinamide;4-methyl-6-(1-methyl-1H-imidazol-5-yl)-N-(pyridin-4-yl)picolinamide;4-methyl-6-(1-methyl-1H-imidazol-2-yl)-N-(pyridin-4-yl)picolinamide;6-(thiazol-5-yl)-N-(6-(trifluoromethyl)pyridin-3-yl)picolinamide;6-(1-methyl-1H-imidazol-2-yl)-N-(6-(trifluoromethyl)pyridin-3-yl)picolinamide;6-(1-methyl-1H-imidazol-2-yl)-N-(pyridin-3-yl)picolinamide;2-(1H-imidazol-1-yl)-6-methyl-N-(pyridin-3-yl)pyrimidine-4-carboxamide;2-(1H-imidazol-1-yl)-6-methyl-N-(pyridin-4-yl)pyrimidine-4-carboxamide;6-cyclopropyl-2-(1 H-imidazol-1 -yl)-N-(2-(trifluoromethyl)pyridin-4-yl)pyrimidine-4- carboxamide;6-(1 H-imidazol-1 -yl)-4-methyl-N-(pyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-methyl-N-(pyridin-3-yl)picolinamide;N-(6-carbamoylpyridin-3-yl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;N-(2-carbamoylpyridin-4-yl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;6-(1 H-imidazol-1 -yl)-4-methyl-N-(2-(methylcarbamoyl)pyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-methyl-N-(6-(methylcarbamoyl)pyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-5-methyl-N-(pyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-3-methyl-N-(pyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-5-methoxy-N-(pyridin-3-yl)picolinamide;5-fluoro-6-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)picolinamide;3-fluoro-6-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-3-methoxy-N-(pyridin-3-yl)picolinamide;3-amino-6-(1 H-imidazol-1 -yl)-N-(pyridin-4-yl)picolinamide;3-amino-N-(2-fluoropyridin-4-yl)-6-(1 H-imidazol-1 -yl)picolinamide;3-amino-6-(1 H-imidazol-1-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)picolinamide;4-amino-6-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)picolinamide;-(1 H-imidazol-1 -yl)-4-(methylamino)-N-(pyridin-3-yl)picolinamide; -(1H-imidazol-1-yl)-N-(pyridin-3-yl)pyrimidine-4-carboxamide; -(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)pyrazine-2-carboxamide; -(1 H-imidazol-1 -yl)-2-((3-methyloxetan-3-yl)oxy)-N-(2-(trifluoromethyl)pyridin-4- yl )pyri m id i ne-4-carboxa m ide ; -(1 H-imidazol-1 -yl)-6-((tetrahydro-2H-pyran-4-yl)methoxy)-N-(2-(trifluoromethyl)pyridin- 4-yl)pyrimidine-4-carboxamide; -(1-methyl-1H-imidazol-5-yl)-6-((tetrahydro-2H-pyran-4-yl)methoxy)-N-(2- (trifluoromethyl)pyridin-4-yl)pyrimidine-4-carboxamide; -(1-methyl-1H-imidazol-2-yl)-6-((tetrahydro-2H-pyran-4-yl)methoxy)-N-(2- (trifluoromethyl)pyridin-4-yl)pyrimidine-4-carboxamide; -(2-methoxyethoxy)-2-(1-methyl-1H-imidazol-5-yl)-N-(2-(trifluoromethyl)pyridin-4- yl )pyri m id i ne-4-carboxa m ide ; -(2-methoxyethoxy)-2-(1-methyl-1H-imidazol-2-yl)-N-(2-(trifluoromethyl)pyridin-4- yl )pyri m id i ne-4-carboxa m ide ; -(2-methoxyethoxy)-2-(1-methyl-1H-pyrazol-5-yl)-N-(2-(trifluoromethyl)pyridin-4- yl )pyri m id i ne-4-carboxa m ide ; -(2-hydroxy-2-methyl propoxy )-2-(1H-imidazol-1-yl)-N-(2-(trifluoromethyl)pyridin-4- yl )pyri m id i ne-4-carboxa m ide ; -(1 H-imidazol-1 -yl)-N-(pyridin-4-yl)pyrimido[5,4-d]pyrimidin-4-amine; -(1-methyl-1H-imidazol-5-yl)-6-((3-methyloxetan-3-yl)oxy)-N-(2-(trifluoromethyl)pyridin- 4-yl)pyrimidine-4-carboxamide; -(1-methyl-1H-imidazol-2-yl)-6-((3-methyloxetan-3-yl)oxy)-N-(2-(trifluoromethyl)pyridin- 4-yl)pyrimidine-4-carboxamide; -(1-methyl-1H-pyrazol-5-yl)-6-((3-methyloxetan-3-yl)oxy)-N-(2-(trifluoromethyl)pyridin-4- yl )pyri m id i ne-4-carboxa m ide ; -(((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-1-methyl-7-(thiazol-5-yl)quinolin- 2(1H)-one;4-(((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin- 2(1 H)-one;1-ethyl-4-(((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-6-(thiazol-5-yl)quinolin-2(1H)- one;4-(((1r,4r)-4-methoxycyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one;4-(((1 r,4r)-4-hydroxycyclohexyl)amino)-1 -methyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;4-(((1 r,4r)-4-methoxycyclohexyl)amino)-1 ,8-dimethyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;4-(((1r,4r)-4-(aminomethyl)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)- one;4-(((1 r,4r)-4-aminocyclohexyl)amino)-1 -methyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;1-methyl-4-(piperidin-4-ylamino)-6-(thiazol-5-yl)quinolin-2(1 H)-one;1-methyl-4-((tetrahydro-2H-pyran-4-yl)amino)-6-(thiazol-5-yl)quinolin-2(1H)-one;6-methoxy-1-methyl-4-(piperidin-4-ylamino)quinolin-2(1 H)-one;4-amino-1 -methyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;4-((1-(benzo[d][1 ,3]dioxol-5-ylmethyl)piperidin-4-yl)amino)-6-chloro-1-(thiazol-5- yl methyl )quinolin-2(1 H)-one;4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)-2-methylquinoline-8-carboxamide;2-methyl-4-((2,3,6-trichlorobenzyl)amino)quinoline-8-carboxamide;4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid; potassium 4,5-dihydroxy-9, 10-dioxo-9, 10-dihydroanthracene-2-carboxylate;5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one;2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6- (hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)chromenylium;1-((2R,3S,4S,5R)-5-((((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4- dihydroxytetrahydrofuran-2- yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-3,4- dihydroxytetrahydrofuran-2-yl)-3-carbamoylpyridin-1-ium;1-((2R,3S,4R,5R)-5-((((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4- dihydroxytetrahydrofuran-2- yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-3-fluoro-4- hyd roxytetrahyd rof u ra n-2-y I )-3-ca rba moy I py rid i n- 1 -i u m ;3-carbamoyl-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-((phosphonooxy)methyl)tetrahydrofuran-2-yl)pyridin-1-ium;1-((1 R,2S,3R,4R)-4-((((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4- dihydroxytetrahydrofuran-2- yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-2,3- dihydroxycyclopentyl)-3-carbamoylpyridin-1-ium;3-carbamoyl-1-((2R,3R,4S,5R)-5-((((((((2R,3S,4R,5R)-5-(2-fluoro-6-imino-1,6- dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2- yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-3,4- dihydroxytetrahydrofuran-2-yl)pyridin-1-ium;3-carbamoyl-1-((2R,3S,4S,5R)-5-((((((((2R,3S,4R,5R)-5-(2-fluoro-6-imino-1,6- dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2- yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-3,4- dihydroxytetrahydrofuran-2-yl)pyridin-1-ium;3-carbamoyl-1-((2R,3S,4R,5R)-5-((((((((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-imino-1,6- dihydro-9H-purin-9-yl)tetrahydrofuran-2- yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-3-fluoro-4- hyd roxytetrahyd rof u ra n-2-y I )py rid i n- 1 -i u m ;3-carbamoyl-1-((2R,3R,4R,5R)-5-((((((((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-imino-1 ,6- dihydro-9H-purin-9-yl)tetrahydrofuran-2- yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-3-fluoro-4- hyd roxytetrahyd rof u ra n-2-y I )py rid i n- 1 -i u m ;(1R,3S)-1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2, 3,4,9- tetrahydro-1 H-pyrido[3,4-b]indole-3-carboxylic acid;5-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1H-benzo[d]imidazole-7- carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-5-(1H-imidazol-1-yl)-1H-benzo[d]imidazole-7- carboxamide;N-[[2-Fluoro-6-(trifluoromethyl)phenyl]methyl]-6-thiazol-5yl-3H-benzimidazole-4- carboxamide;N-((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-5-(thiazol-5-yl)-1 H-benzo[d]imidazole-7- carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-5-(1H-imidazol-1-yl)-1H-indole-7-carboxamide;N-((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-5-(thiazol-5-yl)-1 H-indole-7-carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;5-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1H-indazole-7- carboxamide;5-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2-methyl-1H-indole-7- carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 H-pyrrolo[3,2- b]pyridine-7-carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-2-methyl-5-(thiazol-5-yl)-1 H-indole-7-carboxamide;5-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1H-pyrrolo[2,3- c] pyrid i ne-7 -carboxa m ide;N-((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-2-methyl-5-(thiazol-5-yl)-1H- benzo[d]imidazole-7-carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-7H-purine-6- carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[4,3-b]pyridine-7- carboxamide;5-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-5-(thiazol-5-yl)-1 H-pyrazolo[4,3-b]pyridine-7- carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)thieno[3,2-d]pyrimidine-4- carboxamide;2-(Aminomethyl)-5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 H- indole-7-carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-2-(thiazol-5-yl)thieno[3,2-d]pyrimidine-4- carboxamide;N-((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-5-(thiazol-5-yl)-1H-pyrazolo[3,4-c]pyridine-7- carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-5-methyl-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;5-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;5-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)thieno[3,2-b]pyridine-7- carboxamide;5-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)thiazolo[4,5-d]pyrimidine-7-carboxamide;6-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-3H-imidazo[4,5- c] pyrid i ne-4-carboxa m ide;2-(1H-lmidazol-1-yl)-N-(tetrahydro-2H-pyran-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;(S)-2-(1H-lmidazol-1-yl)-N-(tetrahydro-2H-pyran-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;(R)-2-(1H-imidazol-1-yl)-N-(tetrahydro-2H-pyran-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;4-Fluoro-5-(1 H-imidazol-1 -yl)-N-((1r, 4r)-4-(2-methoxyethoxy)cyclohexyl)-1H-indole-7- carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2-methyl-1 H- benzo[d]imidazole-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2-methyl-1 H- benzo[d]imidazole-7-carboxamide;N-((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-2-(thiazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-(thiazol-5-yl)-3l-imidazo[4,5-c]pyridine-4- carboxamide;N-((1 r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-2-(2-methyl-1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-2-(5-methyl-1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2-(4-methyl-1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1H-lmidazol-4-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-((1s,4s)-4-(trifluoromethyl)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(trifluoromethyl)cyclohexyl)-5H-pyrrolo[3,2-d]pyrimidine- 4-carboxamide;5-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)benzo[d]isothiazole-7- carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-5-(1 H-imidazol-1 -yl)-2-methyl-1H- benzo[d]imidazole-7-carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-2-(thiazol-5-yl)- 5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrrolo[3,2-b]pyridine-7- carboxamide;N-((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-2-methyl-5-(thiazol-5-yl)-1H-indole-7- carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-2-(1H-imidazol-1-yl)-7H-purine-6-carboxamide;N-((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-6-(thiazol-5-yl)-3H-imidazo[4,5-c]pyridine-4- carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-5-(1H-imidazol-1-yl)-1H-pyrazolo[3,4-c]pyridine-7- carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-2-(1H-imidazol-1-yl)thieno[3,2-d]pyrimidine-4- carboxamide;N-((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-2-(thiazol-5-yl)thieno[3,2-d]pyrimidine-4- carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine- 4-carboxamide;2-(1H-lmidazol-1-yl)-N-(1-(2-methoxyethyl)piperidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(piperidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(1-(3,3,3-trifluoropropyl)piperidin-4-yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,4r)-4-((2-methoxyethyl)amino)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,4r)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,4r)-4-methoxycyclohexyl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-cyclohexyl-2-(1H-lmidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(1-methylpiperidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(tetrahydro-2H-pyran-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(4-(2-methoxyethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-(1-Acetylpiperidin-4-yl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,3r)-3-(2-methoxyethoxy)cyclobutyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,3r)-3-methoxycyclobutyl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(1-(3,3,3-trifluoropropyl)pyrrolidin-3-yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(1 -(2, 2, 2-trifluoroethyl)pyrrolidin-3-yl)-5H-pyrrolo[3,2-d] pyrimidine- 4-carboxamide;2-(1H-lmidazol-1-yl)-N-((1s,4s)-4-(2-methoxyethoxy)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-methyl-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-(methylamino)ethoxy)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(2-(Dimethylamino)ethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(pyrrolidin-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(1 -methyl pyrrol idin-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(1-(methylsulfonyl)piperidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(1-(oxetan-3-yl)piperidin-4-yl)- 5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-Cyclobutyl-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-(Cyclohexylmethyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-Benzyl-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-(methylamino)-2-oxoethoxy)cyclohexyl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(pyridin-2-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-phenyl-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(pyridin-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(5-methoxypyridin-2-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(6-methoxypyridin-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(1H-pyrazol-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-(4-Chlorophenyl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-(3-Chlorophenyl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-(2-Chlorophenyl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-Cyclopentyl-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(tetrahydrofuran-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-Cycloheptyl-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-isopropyl-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(1-methyl-1H-pyrazol-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(1-methyl-1H-imidazol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-(3-Chloro-4-fluorophenyl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-morpholinoethoxy)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(1H-pyrazol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(1-methyl-1H-pyrazol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(3-(2-methoxyethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-((2,2,2-trifluoroethyl)amino)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1s,4s)-4-((2, 2, 2-trifluoroethyl)amino)cyclohexyl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-((3,3,3-trifluoropropyl)amino)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(cyanomethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine- 4-carboxamide;N-((1r,4r)-4-((2,2-difluoroethyl)amino)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-((1s,4s)-4-((2,2-difluoroethyl)amino)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-(4,4-difluorocyclohexyl)-5-(1 H-imidazol-1 -yl )- 1 H-pyrazolo[3,4-c]pyridine-7- carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-methyl-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(methyl(3,3,3-trifluoropropyl)amino)cyclohexyl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1s, 4s)-4-(methyl(3, 3, 3-trifluoropropyl)amino)cyclohexyl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(methyl(2,2,2-trifluoroethyl)amino)cyclohexyl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1s, 4s)-4-(methyl(2, 2, 2-trifluoroethyl)amino)cyclohexyl )-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(acetamidomethyl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-((2,2,2-trifluoroethyl)amino)cyclohexyl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;5-(1 H-imidazol-1 -yl)-N-((1s,4s)-4-((2, 2, 2-trifl uoroethyl)amino)cyclohexyl)-1H- pyrazolo[3,4-c]pyridine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1s,4s)-4-((2, 2, 2-trifl uoroethyl)amino)cyclohexyl)-1H- pyrazolo[3,4-c]pyridine-7-carboxamide;N-(4,4-difluorocyclohexyl)-2-(1 H-imidazol-1 -yl)-8-methyl-7H-purine-6-carboxamide;N-((1 R,4r)-4-((R)-2-hydroxy-3-methylbutoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-((1S,4r)-4-((S)-2-hydroxy-3-methylbutoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-((1 s,4s)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(trifluoromethyl)cyclohexyl)thieno[3,2-d]pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1s, 4s)-4-(trifluoromethyl)cyclohexyl)thieno[3,2-d]pyrimidine-4- carboxamide;N-((3S,4R)-3-fluoropiperidin-4-yl)-2-(1 H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-((3R,4R)-3-fluoropiperidin-4-yl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 S,3S)-3-(2-methoxyethoxy)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 S,3R)-3-(2-methoxyethoxy)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 R,4r)-4-((R)-2-hydroxypropoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 R,4r)-4-((S)-2-hydroxypropoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-((1 R,4r)-4-((R)-2-hydroxy-2,3-dimethylbutoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-((1 R,4r)-4-((S)-2-hydroxy-2,3-dimethyl butoxy )cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 R,4r)-4-((R)-3,3,3-trifluoro-2-hydroxy-2- methylpropanamido)cyclohexyl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 R,4r)-4-((S)-3,3,3-trifluoro-2-hydroxy-2- methylpropanamido)cyclohexyl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxy-4-methylcyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide ;2-(1 H-imidazol-1 -yl)-N-((1s, 4s)-4-methoxy-4-methylcyclohexyl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-(5-(2-(dimethylamino)ethoxy)pyridin-2-yl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-(4-cyanophenyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-(3-fluoro-4-(2-methoxyethoxy)phenyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(1-(methoxymethyl)-1H-pyrazol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine- 4-carboxamide;N-((1 r,4r)-4-(2-(2-(dimethylamino)ethoxy)ethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-(5-chloropyridin-2-yl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(4-methyltetrahydro-2H-pyran-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)thieno[3,2-d]pyrimidine-4- carboxamide;N-(6-chloropyridin-3-yl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-imidazol-1-yl)-N-(pyridin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-((1r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-(2-chloropyridin-4-yl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-(5-chloropyridin-3-yl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-(4-chloropyridin-2-yl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(1-(2-morpholinoacetyl)piperidin-4-yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-(6-chloropyridin-2-yl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-imidazol-1-yl)-N-(6-(2-morpholinoethoxy)pyridin-3-yl)-5H-pyrrolo[3,2-d]pyrimidine- 4-carboxamide;N-((1r,4r)-4-(2-(dimethylamino)-2-oxoethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(trifluoromethyl)cyclohexyl)-7H-purine-6-carboxamide;N-((1r,4r)-4-cyanocyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-(4,4-difluorocyclohexyl)-2-(1 H-imidazol-1 -yl)thieno[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(pyrimidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-(6-(2-(dimethylamino)ethoxy)pyridin-3-yl)-2-(1 H-imidazol-1 -yl)thieno[3, 2-d]pyrimidine- 4-carboxamide;N-(4,4-difluorocyclohexyl)-2-(1 H-imidazol-1 -yl)-7H-purine-6-carboxamide;2-(1 H-imidazol-1 -yl)-N-(pyrimidin-5-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(6-(4-methylpiperazin-1 -yl)pyridin-3-yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-morpholinocyclohexyl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-(5-chloro-6-(2-morpholinoethoxy)pyridin-3-yl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-(2-(4,4-difluorocyclohexyl)ethyl)-2-(1 H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-(6-(4-morpholinopiperidin-1-yl)pyridin-3-yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-(4,4-difluorocyclohexyl)-5-(1 H-imidazol-1 -yl )- 1 H-pyrazolo[4,3-d]pyrimidine-7- carboxamide;5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(trifluoromethyl)cyclohexyl)-1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1s,4s)-4-(trifluoromethyl)cyclohexyl)-1 H-pyrazolo[4, 3- d]pyrimidine-7-carboxamide;2-(1 H-imidazol-1 -yl)-N-(isoxazol-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(2-(2-methoxyethyl)-1 ,2, 3, 4-tetrahydroisoquinolin-7-yl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(1-phenylcyclopropyl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-(2-(2-methoxyethoxy)pyrimidin-5-yl)-5H-pyrrolo[3,2-d] pyrimidine- 4-carboxamide;N-(((1 r,4r)-4-cyanocyclohexyl)methyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine- 4-carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(trifluoromethoxy)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1r,4r)-4-fluorocyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1s, 4s)-4-morpholinocyclohexyl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(methylcarbamoyl)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(trifluoromethyl)cyclohexyl)-1 H-pyrazolo[3,4-c]pyridine- 7-carboxamide;N-(2-acetyl-2-azabicyclo[2.2.1]heptan-5-yl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-(4,4-difluorocyclohexyl)-2-(1H-imidazol-1-yl)-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-((1r,4r)-4-(hydroxymethyl)cyclohexyl)-2-(1 H-imidazol-1-yl)-5H-pyrrolo[3,2-d] pyrimidine- 4-carboxamide;N-((1 s,4s)-4-hydroxy-4-methylcyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-((1r,4r)-4-hydroxycyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-((1r,4r)-4-(1 ,1-dioxidoisothiazolidin-2-yl)cyclohexyl)-2-(1H-imidazol-1-yl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(2-(2-methoxyethyl)-1 ,2, 3, 4-tetrahydroisoquinolin-6-yl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-((3,3-difluoropropyl)amino)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-1 H-pyrazolo[4,3-d]pyrimidine-7- carboxamide;N-((1r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methyl-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(cyanomethyl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine- 4-carboxamide;N-((1 s,4s)-4-hydroxycyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxypropan-2-yl)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1s, 4s)-4-((3, 3, 3-trifluoropropyl)amino)cyclohexyl )-1H- pyrazolo [3 c] pyrid i ne-7-carboxa m ide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-((3,3,3-trifluoropropyl)amino)cyclohexyl)-1 H- pyrazolo[3,4-c]pyridine-7-carboxamide;N-(6-(3-(dimethylamino)prop-1-yn-1-yl)pyridin-3-yl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-((2,2,2-trifluoroethyl)amino)cyclohexyl)-1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;N-((1 S,4r)-4-((S)-1-hydroxyethyl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1 R,4r)-4-((R)-1-hydroxyethyl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1 r,4r)-4-((2,2-difluoropropyl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1s,4s)-4-((2,2-difluoropropyl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1H-pyrazolo[3, 4- c] pyrid i ne-7 -carboxa m ide;N-((1 r,4r)-4-((2,2-difluoroethyl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2-methyl-2H- pyrazolo[3,4-c]pyridine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 -methyl-1 H- pyrazolo[3,4-c]pyridine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)thieno[2,3-c]pyridine-7- carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-(methylamino)-2-oxoethyl)cyclohexyl)-1 H- pyrazolo[3,4-c]pyridine-7-carboxamide;N-((1 r,4r)-4-(2-hydroxyethyl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(2-(dimethylamino)-2-oxoethoxy)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H- pyrazolo[4,3-d]pyrimidine-7-carboxamide;N-((1 r,4r)-4-(2-(dimethylamino)-2-oxoethoxy)cyclohexyl)-5-(1 H-imidazol-1-yl)-1 H- pyrazolo[3,4-c]pyridine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-(6-(2-(pyrrolidin-1 -yl)ethoxy)pyridin-3-yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1 r,4r)-4-(3,3-difluoroazetidin-1 -yl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-(4-cyanophenyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4-c]pyridine-7-carboxamide;N-((1 r,4r)-4-(2,2-difluoroethylamino)cyclohexyl)-5-(1 H-imidazol-1 -yl )- 1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;N-((1 S,4r)-4-((S)-2-hydroxypropoxy)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1 R,4r)-4-((R)-2-hydroxypropoxy)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1 r,4r)-4-(acetamidomethyl)cyclohexyl)-5-(1 H-imidazol-1 -yl )-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)-2-(1 H-imidazol-1 -yl)thieno[3, 2- d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(isoindolin-5-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(4-cyanophenoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(methylsulfonyl)cyclohexyl)-5H-pyrrolo[3,2-d]pyrimidine- 4-carboxamide;N-((1 r,4r)-4-(cyanomethoxy)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;N-((1 r,4r)-4-(cyanomethoxy)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4-c]pyridine- 7-carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(oxetan-3-ylamino)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(methylcarbamoyl)cyclohexyl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(methyl(2,2,2-trifluoroethyl)amino)cyclohexyl)-1 H- pyrazolo[3,4-c]pyridine-7-carboxamide;N-((1 r,4r)-4-(cyanomethyl)cyclohexyl)-5-(1 H-imidazol-1 -yl )- 1 H-pyrazolo[3,4-c]pyridine-7- carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2,2,2-trifluoroethylamino)cyclohexyl)thieno[3,2- d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(2,2-difluoroethylamino)cyclohexyl)-2-(1 H-imidazol-1 -yl)thieno[3,2- d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-((3,3,3-trifluoropropyl)amino)cyclohexyl)thieno[3,2- d]pyrimidine-4-carboxamide;N-(6-(2-(dimethylamino)ethoxy)pyridin-3-yl)-5-(1 H-imidazol-1 -yl )-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;5-(1 H-imidazol-1 -yl)-N-(6-(piperazin-1 -yl )pyrid i n-3-yl )- 1 H-pyrazolo[3,4-c]pyridine-7- carboxamide;N-((1 r,4r)-4-(hydroxymethyl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4-c]pyridine- 7-carboxamide;N-((1 s,4s)-4-hydroxy-4-methylcyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1 r,4r)-4-(3,3-difluoroazetidin-1 -yl)cyclohexyl)-5-(1 H-imidazol-1 -yl )-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1 r,4r)-4-(1 -hydroxycyclopropyl)cyclohexyl)-5-(1 H-imidazol-1 -yl )-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;5-(1 H-imidazol-1 -yl)-N-(6-(trifluoromethyl)pyridin-3-yl)-1 H-pyrazolo[3,4-c]pyridine-7- carboxamide;N-(6-(2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethoxy)pyridin-3-yl)-5-(1 H-imidazol-1 -yl)-1 H- pyrazolo[3,4-c]pyridine-7-carboxamide;5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(oxetan-3-ylamino)cyclohexyl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1 r,4r)-4-((2,2-difluoropropyl)amino)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;5-(1 H-imidazol-1 -yl )- N-(isoi ndol i n-5-yl )- 1 H-pyrazolo[3,4-c]pyridine-7-carboxamide ;N-(2-acetylisoindolin-5-yl)-5-(1 H-imidazol-1-yl)-1 H-pyrazolo[3,4-c]pyridine-7- carboxamide;N-((1 r,4r)-4-(1 -hydroxycyclopropyl)cyclohexyl)-5-(1 H-imidazol-1 -yl )-1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1s,4s)-4-methyl-4-((2, 2, 2-trifl uoroethyl)amino)cyclohexyl)-1H- pyrazolo[3,4-c]pyridine-7-carboxamide;5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-methyl-4-((2,2,2-trifluoroethyl)amino)cyclohexyl)-1 H- pyrazolo[3,4-c]pyridine-7-carboxamide;5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(3-(trifluoromethyl)azetidin-1 -yl)cyclohexyl)-1 H- pyrazolo[4,3-d]pyrimidine-7-carboxamide;5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(methylcarbamoyl)cyclohexyl)-1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;N-((1 r,4r)-4-(acetamidomethyl)cyclohexyl)-5-(1 H-imidazol-1 -yl )-1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;N-((1 r,4r)-4-((2,2-difluoropropyl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl )-1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;N-(3,3-difluoropropyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4-c]pyridine-7-carboxamide;N-((1 r,4r)-4-((2,2-difluoropropyl)amino)cyclohexyl)-2-(1 H-imidazol-1 -yl)thieno[3,2- d]pyrimidine-4-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1s,4s)-4-methyl-4-((2, 2, 2-trifl uoroethyl)amino)cyclohexyl)-1H- pyrazolo[3,4-c]pyridine-7-carboxamide;5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(methyl(2,2,2-trifluoroethyl)amino)cyclohexyl)-1 H- pyrazolo[4,3-d]pyrimidine-7-carboxamide;5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(3,3,3-trifluoropropoxy)cyclohexyl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(((2,2,2-trifluoroethyl)amino)methyl)cyclohexyl)-1 H- pyrazolo [3 c] pyrid i ne-7-carboxa m ide;5-(1 H-imidazol-1 -yl)-N-((1s,4s)-4-(2, 2, 2-trifluoroethoxy)cyclohexyl)-1H-pyrazolo[3, 4- c] pyrid i ne-7 -carboxa m ide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2,2,2-trifluoroethoxy)cyclohexyl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1r,4r)-4-((1,1-difluoro-2-methylpropan-2-yl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl)- 1H-pyrazolo[3,4-c]pyridine-7-carboxamide;N-((1s,4s)-4-((1,1-difluoro-2-methylpropan-2-yl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl)- 1H-pyrazolo[3,4-c]pyridine-7-carboxamide;N-((1 r,4r)-4-(3,3-difluoroazetidin-1 -yl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;N-((1s,4s)-4-(3-fluoro-3-methylazetidin-1-yl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H- pyrazolo[4,3-d]pyrimidine-7-carboxamide;N-((1 r,4r)-4-(3-fluoro-3-methylazetidin-1 -yl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H- pyrazolo[4,3-d]pyrimidine-7-carboxamide;N-((1 r,4r)-4-(3-cyano-3-methylazetidin-1-yl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H- pyrazolo[3,4-c]pyridine-7-carboxamide;N-((1s,4s)-4-(3-cyano-3-methylazetidin-1-yl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1H- pyrazolo[3,4-c]pyridine-7-carboxamide;N-((1s,4s)-4-(3-cyano-3-methylazetidin-1-yl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1H- pyrazolo[3,4-c]pyridine-7-carboxamide;N-((1r,4r)-4-((2,2-difluoroethyl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl)thieno[2, 3- c] pyrid i ne-7 -carboxa m ide;N-((1 r,4r)-4-((2,2-difluoropropyl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl)thieno[2,3- c] pyrid i ne-7 -carboxa m ide;N-((1 r,4r)-4-(1 -hydroxycyclopropyl)cyclohexyl)-5-(1 H-imidazol-1 -yl)thieno[2,3-c]pyridine- 7-carboxamide;N-((1 R,4r)-4-((R)-1-hydroxyethyl)cyclohexyl)-5-(1 H-imidazol-1 -yl)thieno[2, 3-c]pyridine-7- carboxamide;N-((1S,4r)-4-((S)-1-hydroxyethyl)cyclohexyl)-5-(1H-imidazol-1-yl)thieno[2,3-c]pyridine-7- carboxamide;N-((1 r,3r)-3-(2-hydroxypropan-2-yl)cyclobutyl)-5-(1 H-imidazol-1-yl)-1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;N-((1 r,3r)-3-(2-hydroxypropan-2-yl)cyclobutyl)-5-(1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1 R,4r)-4-((R)-1-hydroxyethyl)cyclohexyl)-2-(1 H-imidazol-1 -yl)thieno[3,2-d]pyrimidine- 4-carboxamide;N-((1S,4r)-4-((S)-1-hydroxyethyl)cyclohexyl)-2-(1 H-imidazol-1 -yl)thieno[3,2-d]pyrimidine- 4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-7-methyl-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(3-cyanoazetidin-1-yl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-((2,2,2-trifluoroethyl)amino)cyclohexyl)thieno[2,3- c] pyrid i ne-7 -carboxa m ide;5-(1 H)-imidazol-1 -yl)-N-((1 r,4r)-4-(((2,2,2-trifluoroethyl)amino)methyl)cyclohexyl)-1 H- pyrazolo[4,3-d]pyrimidine-7-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-((1 , 1 ,1 -trifluoro-2-methylpropan-2-yl)amino)cyclohexyl)- 5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-((1r,4r)-4-((1,1-difluoro-2-methylpropan-2-yl)amino)cyclohexyl)-2-(1 H-imidazol-1 -yl)- 5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1s,4s)-4-methyl-4-((2, 2, 2-trifl uoroethyl)amino)cyclohexyl )-1H- pyrazolo[4,3-d]pyrimidine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methyl-4-((2,2,2-trifluoroethyl)amino)cyclohexyl)-1 H- pyrazolo[4,3-d]pyrimidine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-((1 , 1 ,1 -trifluoro-2-methylpropan-2-yl)amino)cyclohexyl)- 1H-pyrazolo[4,3-d]pyrimidine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1s,4s)-4-((1 , 1,1 -trifl uoro-2-methylpropan-2-yl)amino)cyclohexyl )- 1H-pyrazolo[4,3-d]pyrimidine-7-carboxamide;-(1H-imidazol-1-yl)-4-(((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-1-methylquinolin- 2(1 H)-one; -1 H-imidazol-1-yl)-1-methyl-4-(((1r,4r)-4(oxetan-3-ylaminocyclohexyl)amino)quinolin- 2(1 H)-one; -(1 H-imidazol-1 -yl)-4-(((1r,4r)-4-2-methoxyethoxy)cyclohexyl)amino)-1-methyl-1, 5- naphthyridin-2(1 H)-one; -(((1r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)amino)-6-(1 H-imidazol-1 -yl)-1-methyl-1 ,5- naphthyridin-2(1 H)-one; -(((1r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)amino)-6-(1 H-imidazol-1 -yl)-1-methyl-1, 7- naphthyridin-2(1 H)-one; -(1 H-imidazol-1 -yl)-4-(((1r,4r)-4-(2-methoxyethoxylcyclohexyl)amino)-1-methyl-1, 7- naphthyridin-2(1 H)-one; -(1 H-imidazol-1 -yl )-8-(((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-5- methylpyrido[3,2-d]pyrimidin-6(5H)-one; -(((1r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)amino)-2-(1 H-imidazol-1 -yl)-5- methylpyrido[3,2-d]pyrimidin-6(5H)-one; -(1 H-imidazol-1 -yl)-5-methyl-8-(4-trifluoromethyl)phenyl)aminopyrido[3,2-d]pyrimidin- 6(5H)-one; -(1 H-imidazol-1 -yl)-5-methyl-8-6-(2-morpholinoethoxy)pyridin-3-yl)amino)pyrido[3, 2- d] pyri m id i n-6(5H )-o ne ; -(1 H-imidazol-1 -yl)-1-methyl-4-((1r,4r)-4-(2, 2,2- trifluoroethyl)amino)cyclohexyl)amino)quinolin-2(1 H)one; -(((1r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)amino)-6-(1 H-imidazol-1 -yl)-1 - methylquinolin-2(1 H)-one; -(1 H-imidazol-1 -yl)-1-methyl-4-(1-(methylsulfonyl)piperidin-4-yl)amino)quinolin-2(1H)- one; -(((1r,4r)-4-(6-(1 H-imidazol-1 -yl)-1-methyl-2-oxo-1,2-dihydroquinolin-4- yl )am i nocyclo hexyl )oxy)-N , Nd i methylaceta m ide ; -(1 H-imidazol-1 -yl)-1-methyl-4-((6-(2, 2, 2-trifluoroethoxy)pyridin-3-yl)amino)quinolin- 2(1 H)-one;-(((1r,4r)-4-(2,2-difluoropropyl)amino)cyclohexyl)amino)-6-(1 H-imidazol-1 -yl)-1- methylquinolin-2(1 H)-one; -((-(2-(dimethylamino)ethoxy)pyridin-3-yl)amino)-6-(1H-imidazol-1-yl)-1 -methylquinolin- 2(1 H)-one; -(1H-imidazol-1-yl)-1-methyl-4-(((1r,4r)-4-(2(pyrrolidin-1- yl)ethoxy)cyclohexyl)amino)quinolin-2(1H)-one; -(((1 r,4r)-4-(2,2-difluoropropyl)aminocyclohexyl)amino)-2-(1 H-imidazol-1 -yl )-5- methylpyrido[3,2-d]pyrimidin-6(5H)-one; -(1S,4r)-4-((S)-1-hydroxyethyl)cyclohexyl)amino)-2-(1 H-imidazol-1 -yl)-5- methylpyrido[3,2-d]pyrimidin-6(5H)-one; -(((1r,4r)-4-((2-(1 H-imidazol-1 -yl )-5-methyl-6-oxo-5, 6-dihydropyrido[3, 2-d]pyrimidin-8- yl)amino)cyclohexyl)oxy)-N,N-dimethylacetamide; -((2-(1 H-imidazol-1 -yl)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8- yl)amino)benzonitrile; -(1 H-imidazol-1 -yl)-5-methyl-8-(((1 r,4r)-4-(2,2,2- trifluoroethyl)amino)cyclohexyl)amino)pyrido[3,2-d]pyrimidin-6(5H)-one; -(1 H-imidazol-1 -yl )-8-(((1 r,4r)-4-methoxycyclohexyl)amino)-5-methylpyrido[3,2- d] pyri m id i n-6(5H )-o ne ; -1 H-imidazol-1 -yl)-5-methyl-8-6-(2-(pyrrolidin-1-yl)ethoxy)pyridin-3-yl)amino)pyrido[3, 2- d]pyrimidin-(5H)-one; -(4,4-difluorocyclohexyl)amino)-2-(1 H-imidazol-1 -yl)-5-methylpyrido[3,2-d]pyrimidin- 6(5H)-one; -(((1r,4r)-4-(1-hydroxycyclopropyl)cyclohexyl)amino)-2-(1 H-imidazol-1 -yl)-5- methylpyrido[3,2-d]pyrimidin-6(5H)-one; -(((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-5-methyl-2-(thiazol-5-yl)pyrido[3,2- d] pyri m id i n-6-(5 H )-o ne ; -Phenyl-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -(4-Chloro-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -[1-Pyridin-4-yl-meth-(Z)-ylidene]-3-m-tolyl-imidazolidine-2, 4-dione;-(4-Ethyl-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -(3-Chloro-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -(3,4-Dichloro-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -Benzyl-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -(4-Methylsulfanyl-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;-Cyclohexyl-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -(3,4-Difluoro-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -{2,5-Dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-l-yl}-benzonitrile; -(4-Fluoro-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -(3-Acetyl-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -(4-Dimethylamino-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;-{2,5-Dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-l-yl}-benzoic acid; -[1-Pyridin-4-yl-meth-(Z)-ylidene]-3-(3-trifluoromethyl-phenyl)-imidazolidine-2, 4-dione;-(4-Methoxy-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -[1-Pyridin-4-yl-meth-(Z)-ylidene]-3-p-tolyl-imidazolidine-2, 4-dione; -(4-Bromo-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -lsopropyl-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -Hexyl-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -(4-Acetyl-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -(4-Butyl-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -(4-Methanesulfinyl-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;-(4-Methanesulfonyl-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;-{2,5-Dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-1-yl}-benzoic acid; -[3-(Morpholine-4-carbonyl)-phenyl]-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine- 2, 4-dione;3-[4-(Morpholine-4-carbonyl)-phenyl]-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine- 2, 4-dione;5-[1-Pyridin-4-yl-meth-(Z)-ylidene]-3-(4-trifluoromethoxy-phenyl)-imidazolidine-2, 4-dione;5-[1-Pyridin-4-yl-meth-(2)-ylidene]-3-(4-trifluoromethyl-phenyl)-imidazolidine-2, 4-dione;(4-{2,5-Dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-1-yl}-phenyl)-acetic acid;3-(4-lodo-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;3-{2,5-Dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-1yl}-N-(2-morpholin-4-yl- ethyl)-benzamide;3-(4-tert-Butyl-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;3-[2-(3,4-Diethoxy-phenyl)-ethyl]-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2,4- dione;5-[1-Pyridin-4-yl-meth-(Z)-ylidene]-3-(2-pyrrolidin-1-yl-ethyl)-imidazolidine-2, 4-dione;3-Adamantan-l-yl-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;3-Pyridin-3-yl-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;3-(4-Hydroxy-cyclohexyl)-5-[1-pyridin-4-yl-meth-(2)-ylidene]-imidazolidine-2, 4-dione;3-Propyl-5-[1-pyridin-4-yl-meth-(2)-ylidene]-imidazolidine-2, 4-dione;3-Sec-Butyl-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;{2,5-Dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-1-yl}-acetic acid ethyl ester;3-(3-Morpholin-4-yl-propyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;3-[4-((2R,6S)-2,6-Dimethyl-morpholine-4-carbonyl)-phenyl]-5-[1-pyridin-4-yl-meth-(Z)- ylidene]-imidazolidine-2, 4-dione;{2,5-Dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-1-yl}-acetic acid;3-[4-(4-Methyl-piperidine-1-carbonyl)-phenyl]-5-[1-pyridin-4-yl-meth-(Z)-ylidene]- imidazolidine-2, 4-dione;5-[1-Pyridin-4-yl-meth-(Z)-ylidene]-3-[4-(pyrrolidine-1-carbonyl)-phenyl]-imidazolidine- 2, 4-dione;N-Cyclopentyl-4-{2,5-dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-1-yl}- benzamide;N-Cyclopropyl-4-{2,5-dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-1-yl}- benzamide;N-Cyclohexyl-4-{2,5-dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-l-yl}- benzamide;3-(3-Hydroxy-2,2-dimethyl-propyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2,4- dione;3-(3,3-Difluoro-cyclobutyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;1-(4-{2,5-Dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-1-yl}-benzoyl)-piperidine-4-carboxylic acid ethyl ester;3-(1-Hydroxy-cyclohexylmethyl)-5-[1-pyridin-4-yl-meth-(2)-ylidene]-imidazolidine-2,4- dione;5-[1-Pyridin-4-yl-meth-(Z)-ylidene]-3-(tetrahydro-pyran-4-ylmethyl)-irnidazolidine-2,4- dione;3-(3-Hydroxy-3-methyl-butyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;3-(1-Hydroxy-cyclopentylmethyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2,4- dione;3-(1-Hydroxy-cyclobutylmethyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2,4- dione;5-[1-Pyridin-4-yl-meth-(Z)-ylidene]-3-(tetrahydro-furan-2-ylmethyl)-imidazolidine-2,4- dione;3-(2-Hydroxy-2-methyl-propyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2,4- dione;3-(trans-4-Hydroxy-cyclohexylmethyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;5-[1-Pyridin-4-yl-meth-(Z)-ylidene]-3-(2, 2, 2-trifluoro-ethyl)-imidazolidine-2, 4-dione;3-(1-Hydroxymethyl-cyclobutyl methyl )-5-[1-pyridin-4-yl-meth-(Z)-yl idene]-imidazolidine-2, 4-dione;3-(1-Hydroxymethyl-cyclopentylmethyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;N-(2-{2,5-Dioxo-4-[1 -pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-1 -yl}-ethyl)-2,2,2- trifl uoro-aceta m ide ;Quercetin;Luteol in;Tyrphostin 8;Juglone;Apigenin;Shikonin;4-chloro-1H-pyrazolo[3,4-d]pyrimidine;(E)-5-amino-4-(2,3-dihydrobenzo[d]thiazol-2-yl)-1-((2,3,4-trihydroxybenzylidene)amino)- 1 ,2-dihydro-3H-pyrrol-3-one;2-(1,4-dioxo-3,4-dihydrophthalazin-2(1H)-yl)-N-(pyridin-3-yl)acetamide;4-((E)-(((Z)-2-(isopropylimino)-4-(thiophen-2-yl)thiazol-3(2H)- yl)imino)methyl)benzene-1,2,3-triol;2,2'-bi(1 ,3-d ithiolyl idene);(E)-2-(3-bromo-4-hydroxy-5-methoxystyryl)-5-isobutylthieno[2,3-d]pyrimidin-4(3H)-one;(E)-3-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-(4-methylthiazol-2-yl)acrylonitrile;(Z)-5-(3-bromo-4-hydroxy-5-methoxybenzylidene)-2-thioxothiazolidin-4-one;(E)-1-(benzo[d]thiazol-2-yl)-3-(3-bromo-4-hydroxy-5-methoxyphenyl)prop-2-en-1-one;(E)-2-(benzo[d]thiazol-2-yl)-3-(3-bromo-4-hydroxy-5-methoxyphenyl)acrylonitrile;(E)-3-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-cyano-N-(2-fluorophenyl)acrylamide;(E)-N-benzyl-3-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-cyanoacrylamide;(E)-3-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-cyano-N-(2-ethoxyphenyl)acrylamide;(E)-2-(1H-benzo[d]imidazol-2-yl)-3-(3-bromo-4-hydroxy-5-methoxyphenyl)acrylonitrile;(E)-3-(3-bromo-4-hydroxy-5-methoxyphenyl)-1-(pyridin-3-yl)prop-2-en-1-one;4-((E)-(2-((E)-2-(1H-imidazol-2-yl)vinyl)-1H-imidazol-4-yl)diazenyl)-2-bromo-6- methoxyphenol;4-((E)-2-(2-((E)-(1H-imidazol-2-yl)diazenyl)-1H-imidazol-4-yl)vinyl)-2-bromo-6- methoxyphenol; a-Linolenic acid;Linolenic acid;Stearic acid;Elaidic acid;Arachidonic acid;Oleic acid;Palmitoleic acid;Tryptophan;Nicotinic acid;Quinolinic acid;Nicotinamide mononucleotide;Nicotinamide riboside; or a pharmaceutically acceptable salt thereof.

[0084] In certain embodiments, the CD38 inhibitor is 4-(((1r,4r)-4-(2- methoxyethoxy)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one.

[0085] Enteroendocrine-pancreatic Hormone Pathway Modulators

[0086] The gastrointestinal system releases a variety of satiety hormones such as glucagon- like peptide 1 (GLP-1), oxyntomodulin (OXYN), and islet amyloid polypeptide (amylin) which relay signals to hypothalamic nuclei and other areas of the subcortical areas of the brain, resulting in feelings of increased fullness and satisfaction.

[0087] In accordance with the various aspects and embodiments of the disclosure, the methods described herein comprise administration of one or more enteroendocrine-pancreatic hormone pathway modulators in combination with one or more CD38 inhibitors. Non-limiting examples of such modulators can include agonists and antagonists of receptors for glucagon- like peptide-1 (GLP-1), glucagon (GCG), gastric inhibitory peptide (GIP), oxyntomodulin (OXYN), peptide YY (PYY), amylin, and insulin. The modulators include exogenously- administered gastrointestinal hormones such as GLP-1, GCG, GIP, OXYN, PYY, amylin, andinsulin, as well as analogs, derivatives, mimetics, and small molecule agonists and antagonists thereof.

[0088] In some aspects and embodiments, the enteroendocrine-pancreatic hormone pathway modulator comprises at least one of the non-limiting examples of: semaglutide, exenatide, liraglutide, lixisenatide, tirzepatide, Noiiglutide, dulaglutide, albiglutide, oxyntomodulin (OXYN), glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), glucagon (GCG), Peptide YY (PYY), amylin, insulin, dapiglutide, efinopegdutide, exendin-4, beinaglutide, efpeglenatide, langlenatide, polyethylene glycol loxenatide, taspoglutide, ecnoglutide, utreglutide, gelpaglutide, apraglutide, maridebart, cafraglutide, pegapamodutide, mazdutide, survodutide, bamadutide, pemvidutide, cotadutide, NN9709, NN9423, Bl 456906, PF-07081532, retatrutide, glutazumab, cagrilintide, premlintide, CagriSema, OXM, NN9748 (NN9794), PYY 1875, NCC0165-1875, NCC0165-1562, YOU, Y242, Y3394, KBP-089, KBP-042, davalintide, AZD6234, AZD9550, , ECC5004, ZP8396, orforglipron, danuglipron, lotiglipron, aleniglipron, AZD5004, DA-15864, ID110521156, MLX-7005, RGT075, GS-4571, OWL833, HD-7671, CT- 996, XW003, MEDI0382, AMG 133, ZP6590, HM15136, HM15211, DA1726, GX-G6, GZR18, HRS9531, BGMO504, PB718, RAY1225, VCT220, VK2735, SCO-094, CT-388, amycretin, Dacra QW II, DA-1726 , NNC0519-0130, CIN-209, CIN-210, CIN-110, or any combination of two or more thereof. In accordance with yet some further embodiments, the methods can further comprise administration of at least one additional active agent such as, for example, agents that can provide for the treatment of a disease, disorder, or condition relating to metabolic dysfunction such as abnormal nutrient metabolism.

[0089] GLP-1, GCG, and GIP and activators / inhibitors thereof.

[0090] In some embodiments, the enteroendocrine hormone pathway modulator comprises a receptor agonist compound (activator) for any one or combination of receptors for human glucose-dependent insulinotropic polypeptide (GIP), glucagon (GCG), and glucagon-like peptide-1 (GLP-1).

[0091] GIP is a 42-amino acid gastrointestinal regulatory peptide that plays a physiological role in glucose homeostasis by stimulating insulin secretion from pancreatic beta cells in the presence of glucose and protecting pancreatic beta cells. GCG is a 29-amino acid peptide hormone, produced from proglucagon in alpha cells of the pancreas. Along with insulin, glucagon plays a role in maintaining blood glucose levels. In response to low blood glucose levels, GCG binds to the glucagon receptor and stimulates glucose production through gluconeogenesis and glycogenolysis in the liver, releasing glucose and fatty acids into thebloodstream. GLP-1 is a 37-amino acid peptide that stimulates insulin secretion, protects pancreatic beta cells, and inhibits glucagon secretion, gastric emptying and food intake which leads to weight loss.

[0092] GLP-1 pathway activators encompass activators of the GLP-1 Receptor. In some embodiments, the GLP-1 pathway activator is a GLP-1 receptor agonist. GCG pathway activators encompass activators of the GCG Receptor. In some embodiments, the GCG pathway activator is a GCG receptor agonist. GIP pathway activators encompass activators of the GIP Receptor. In some embodiments, the GIP pathway activator is a GIP receptor agonist. GIP pathway inhibitors encompass inhibitors of the GIP Receptor. In some embodiments, the GIP pathway inhibitor is a GIP receptor antagonist. In any of the above embodiments, the GLP- 1, GCG, and GIP pathway activators, or inhibitors, include, but are not limited to, antibodies and antigen binding fragments thereof, engineered protein constructs (such as Fc conjugates and multi-functional molecules comprising a GLP-1, GCG, and / or GIP analog), peptides, and small molecules.

[0093] As used herein, the term “analog” with reference to any of the hormone peptides comprising the enteroendocrine-pancreatic hormone pathway modulators, refers to a peptide or modified peptide bearing structural and functional similarities to the naturally-occurring hormone peptide (e.g., GLP-1, GCG, GIP, OXYN, PYY, amylin, or insulin) and is capable of binding to and activating to the receptor(s). Analogs can include peptides or modified peptides comprising a smaller portion of the full peptide hormone amino acid sequence, including smaller peptides or modified peptides comprising one or more an amino acid sequence substitutions. A number of peptide hormone analogs are known in the art such as, for example, the GLP-1 analogs semaglutide, exenatide ER, liraglutide, lixisenatide, tirzepatide, dulaglutide, XW003, Noiiglutide, MEDI0382, and albiglutide and the like.

[0094] The term "receptor agonist" with reference to any of the hormone peptides comprising the enteroendocrine-pancreatic hormone pathway modulators, refers to an agent capable of binding to and activating the receptor(s). For example, GLP-1 is a naturally-occurring agonist of the GLP-1 receptor. Typically, receptor agonists encompass receptor analogs. A receptor agonist may be a small molecule receptor agonist. In some embodiments, the receptor agonist is a long-acting small molecule receptor agonist.

[0095] Peptide YY and activators thereof.

[0096] Peptide YY (PYY) is a 36-amino acid peptide encoded by the PYY gene that is released from cells in the ileum and colon in response to feeding. PYY is related to the pancreatic peptide and is present in two primary forms, PYY1-36 and PYY3-36, which have PP fold structural motifs. In the blood and gut, PYY3-36 is the most common form of the peptide (the product following DPP IV proteolytic cleavage) is known to reduce appetite. PYY3-36 preferentially binds to the Y2 receptor (Y2R) of the Y family of receptors. In some aspects and embodiments described herein, the methods comprise administration of exogenous PYY or a PYY analog as known in the art such as, for example, NN9748, NN9747, NNC0165-1875, Y242, and Y3394, among others.

[0097] Oxyntomodulin and activators thereof.

[0098] Oxyntomodulin (OXM) is an endogenous is a 37-amino acid peptide peptide hormone secreted from the intestines following nutrient ingestion that activates both GLP-1 and glucagon receptors. OXM is known to improve glucose tolerance, promote energy expenditure, accelerate liver lipolysis, inhibit food intake, and delay gastric emptying. Endogenous OXM is rapidly degraded in vivo by several peptidases including DPP IV. A number of biologically active and enzymatically stable OXM-based analogs have been developed as potential therapeutics for metabolic diseases. In some aspects and embodiments described herein, the methods comprise administration of exogenous oxyntomodulin or an oxyntomodulin analog as known in the art such as, for example, Mazdutide (IBI362 or LY3305677), OX-SR (Scott, R., et al., (June 2018), Peptides 104:70-77) and those described in, e.g., US Patents 8367607, 9731031 , 10479819, 11236142, 117133344, 11419918 and US PGPUBs US 20240059770 and 20220177537 (all of which are incorporated by reference), among others.

[0099] Amylin and activators thereof.

[0100] Islet amyloid polypeptide (amylin) relays signals to hypothalamic nuclei and other areas of the subcortical areas of the brain, resulting in feelings of increased fullness and satisfaction. Amylin is a 37-amino-acid polypeptide co-secreted with insulin, playing a primary role in glucose homeostasis by slowing gastric emptying, suppressing glucagon secretion, and initiating an anorectic signal postprandially. Amylin receptors (AMYRs) are located on specific nuclei of the dorsal-vagal-complex located within the hindbrain-the nucleus tractus solitarius (NTS), area postrema (AP), and dorsal motor nucleus of the vagus nerve. Amylin analolgues, amylin receptors (AMYRs), and agonists thereof are targets for treatment of obesity. In some aspects and embodiments described herein, the methods comprise administration ofexogeneous amylin or an amylin analog as known in the art such as, for example, pramlintide or cagrilintide (AM833), among others.

[0101] Insulin modulators.

[0102] In some embodiments, the methods described herein can comprise administration of insulin receptor agonists and / or insulin receptor antagonists as known in the art such as, for example, insulin sensitizers (e.g., metformin and glitazones), insulin secretagogues (e.g., sulfonylureas, incretins), insulin mimetics (short or long acting) and the like.

[0103] As described above, the methods can be used in combination with other methods and active agents that may be useful in treating or preventing a condition, disease, or disorder associated with, caused by, and / or characterized by abnormal nutrient metabolism such as, for example, obesity, Parkinson’s disease, type 2 diabetes, kidney disease, cardiovascular disease, or metabolic liver disease. Additional methods and agents can act through different mechanisms of action than the enteroendocrine-pancreatic hormone pathway modulators, as defined herein, to exert an antagonist or agonist effect on an enteroendocrine hormone pathway.

[0104] In some embodiments, the method of the disclosure can further comprise administration of a dipeptidyl peptidase IV (DPP IV) inhibitor. DPP IV is in the exopeptidase class of proteolytic enzymes. The introduction of modifications, such as non-natural amino acids in enteroendocrine peptide hormones (e.g., GLP-1, GIP, GCG, amylin, oxyntomodulin, etc.) has been shown to increase the proteolytic stability of peptide hormones, and has been demonstrated as particularly effective against proteolysis by DPP IV. Inhibitors of DPP IV are also well known in the art. Thus, in some aspects and embodiments described herein, the methods further comprise administration of a DPP IV inhibitor as known in the art such as, for example, Sitagliptin, Vildagliptin, Saxagliptin, Linagliptin, Gemigliptin, Anagliptin, Teneligliptin, Alogliptin, Trelagliptin, Omarigliptin (MK-3102), Evogliptin, Gosogliptin, Dutogliptin (PHX- 1149 free base), Neogliptin Retagliptin (SP-2086), Denagliptin Cofrogliptin (HSK- 7653, compound 2) Fotagliptin, Prusogliptin, and Berberine, among others.

[0105] In some embodiments, the method of the disclosure can further comprise administration of a beta adrenergic receptor agonist. Beta adrenergic receptors (P-ARs) are classified into three subtypes, Pi, 02, and 3, all of which are coupled to Gs proteins, and two of which also couple to Gi proteins (02, and 03). Gs proteins are linked to adenylyl cyclase, and as such, agonists of 0-ARs generate an increase in intracellular cAMP concentration and activity,resulting in effects such as heart muscle contraction, smooth muscle relaxation and glycogenolysis. Further downstream effectors of cAMP include cAMP-dependent protein kinase (PKA), which mediates some of the intracellular events following hormone binding. In particular, several Pa-ARs have been described as involved in fat mass reduction and inflammatory processes. Further, a common genetic variant in P3-AR (Trp64Arg), has been found to positively correlate with metabolic parameters such as HDL-C (High Density Lipoprotein-Cholesterol) and LDL-C (Low Density Lipoprotein-Cholesterol) accumulation rates and glucose tolerance (see, e.g., Prischich, D. et aL, (2020). "Adrenergic modulation with photochromic ligands". Angew. Chem. Inti. Ed. 60 (7): 3625-31; Tesmer, J. J. et al. (2012-09- 21). "Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility". ACS Chem. Biol. 7 (11): 1830-1839); and Schena, G., and Caplan M.J., (2019-04-16). Cells. 8, 357. Thus, in some aspects and embodiments described herein, the methods further comprise administration of a 0-AR agonist or partial agonist as known in the art such as, for example, mirabegron (YM178), amibegron (SR58611A), vibegron, solabergron (GW427353), ritobegron (KUC-7483), CGP12177A, BRL37344, CL316243, L- 796568, bucindolol, pindolol, propranolol, isoproterenol, isoprenaline, norepinephrine, epinephrine, and nadolol, among others.

[0106] In some embodiments, the method of the disclosure can further comprise administration of a growth / differentiation factor 15 (GDF15) agonist. GDF15 is a protein that in humans is encoded by the GDF15 gene, and is a member of the transforming growth factor beta superfamily. Under normal conditions, GDF15 is expressed in low concentrations in most organs and upreguiated because of injury of organs such as liver, kidney, heart and lung. While the function of GDF15 has not been completely elucidated, it is suggested to have an effect in the regulation of inflammatory pathways, apoptosis, angiogenesis, cell repair, and cell growth. Treatment with recombinant GDF15 in animal models given a high-fat diet was shown to reduce obesity and improve glycemic control through glial-cell-derived neurotrophic factor family receptor a-like (GFRAL)-dependent suppression of food intake, in some aspects and embodiments described herein, the methods further comprise administration of a GDF15 agonist, as known in the art such as, for example, LA-GFD15, LY-3463251, NNC0247-0829, and JNJ-9090 / CIN-109, among others.

[0107] In yet some further aspects and embodiments described herein, the methods can further comprise administration of a leptin sensitizer as known in the art such as, for example, withaferin A, celastrol, and leptin / amylin, among others.

[0108] In yet some further embodiments, the methods can further comprise administration of agents that modulate other targets that are being evaluated as potential therapeutics for a disease or disorder associated with one or more metabolic disorders (e.g., abnormal nutrient metabolism, abnormal glucose metabolism, etc.) such as, for example, activin II receptor modulators (e.g., an agonist such as bimagramab), monoacylglycerol acyltransferase 2 (MGAT2) modulators (e.g., an agonist such as S-309309), G-protein coupled receptor 40 (GPR40) modulators (e.g., an agonist such as SCO-267), and the like.

[0109] Treatment

[0110] As described above, the disclosure provides a method of treating or preventing a metabolic disorder or disease in a subject caused by or characterized by abnormal nutrient metabolism. In certain embodiments, the metabolic disorder or disease associated with, caused by, or characterized by abnormal nutrient metabolism is obesity, Parkinson’s disease, type 2 diabetes, kidney disease, cardiovascular disease, or metabolic liver disease.

[0111] In certain embodiments, the disclosure provides a method for treating or preventing Parkinson’s disease in a subject. In certain embodiments, the disclosure provides a method for treating or preventing kidney disease in a subject. In certain embodiments, the disclosure provides a method for treating or preventing metabolic liver disease in a subject.

[0112] In certain embodiments, the disclosure provides a method of treating or preventing obesity in a subject. As used herein, “obesity” refers to a metabolic disease defined by an excess amount of body fat. The normal amount of body fat is between 25-30% in women and 18-23%, relative to total body weight. Obesity can be defined using any clinically relevant definitions. For example, in adults, body mass index (BMI, kg / m2) is frequently used as a measure of overweight and obesity, wherein overweight is defined as a BMI in the range of 25- 29.9 kg / m2, obesity is defined as a BMI of at least 30 kg / m2, and morbid obesity is defined as a BMI of at least 40 kg / m2. Obesity can als obe defined in adults by central adiposity as measured by waist circumference, with raised weight circumference defined as at least 102 cm in men and at least 88 cm in women. Subjects with obesity may exhibit other symptoms such as increasing fasting plasma glucose, increased fasting plasma triglycerides, decreased fasting high density lipoprotein (HDL) level, and increased blood pressure. Severe complications of obesity include a much higher risk of coronary artery disorder, type 2 diabetes, hyperlipidemia, and hypertension. In certain embodiments, the obesity is sarcopenic obesity.

[0113] In certain embodiments, the disclosure provides a method for treating or preventing cardiovascular disease in a subject. As used herein, “cardiovascular disease” refers to any disease of the heart or blood vessel. In certain embodiments, the disclosure provides a method for treating or preventing cardiovascular disease in a subject, wherein the cardiovascular disease is a disease of the heart, e.g., angina, arrhythmia, coronary artery disease, coronary heart disease, cardiomyopathy, heart attack, heart failure, hypertophic cardiomyopathy, mitral regurgitation, mitral valve prolapse, or pulmonary stenosis. In certain embodiments, the disclosure provides a method for treating or preventing cardiovascular disease in a subject, wherein the cardiovascular disease is a disease of the blood vessel, e.g., peripheral vascular disease, artery disease, carotid artery disease, deep vein thrombosis, venous diseases, or atherosclerosis.

[0114] In certain embodiments, the disclosure provides a method for treating or preventing type 2 diabetes in a subject. As used herein, “type 2 diabetes” refers to a metabolic disease in which the pancreas continues to manufacture insulin, but the body of the subject develops resistance to its effect, resulting in a relative insulin deficiency. In certain embodiments, type 2 diabetes includes prediabetes, wherein one or more early diabetic conditions, such as impaired glucose utilization, abnormal or impaired fasting glucose levels, impaired glucose tolerance, impaired insulin sensitivity, and insulin resistance. In certain embodiments, type 2 diabetes includes double diabetes, which is as combination of type 1 diabetes with features of insulin resistance and type 2 diabetes.

[0115] In certain embodiments as described herein, the subject can be a mammal, such as a human, with a metabolic disorder or disease caused by or characterized by abnormal glucose metabolism, including, for example, those listed hereinabove. In certain embodiments, the subject is an adult subject (i.e. , a subject with an age of at least 20 years). In certain embodiments, the subject is a child or adolescent aged in the range of 2-19 years.

[0116] As described above, in certain embodiments as described herein, the disclosure provides a method for treating or preventing obesity in a subject. Accordingly, in certain embodiments of the disclosure, the subject is obese. For example, in certain embodiments, the subject is an adult subject with a body mass index (BMI) of at least 25, e.g., a BMI in the range of 28-40. In certain embodiments, the subject is a child or adolescent aged in the range of 2-19 years with a BMI of at least the 85thpercentile on the CDC growth charts. In certain embodiments, subject has received at least one therapy for obesity, overweight, or a weight- related condition, but failed to achieve an intended clinical outcome, wherein the intendedclinical outcome is a reduction of body weight by at least 5% of the baseline body weight prior to the start of the at least one therapy. As discussed above, obesity can lead to higher risk for other diseases and disorders. For example, in certain embodiments, the subject has one or more of central adiposity, cardiovascular disease, kidney disease, fatty liver disease, sleep apnea, high blood pressure, high blood triglyceride levels, high blood cholesterol levels, low high-density lipoprotein (HDL) levels, and a hemoglobin A1c (HbA1c) level of 6% or greater.

[0117] The administration of the CD38 inhibitor and the enteroendocrine-pancreatic hormone pathway modulator is not particularly limited and can be determined as appropriate for a particular subject by one of ordinary skill in the art. In certain embodiments, the CD38 inhibitor and the enteroendocrine-pancreatic hormone pathway modulator are administered concurrently (i.e., wherein there is an overlapping period of time between the administration of the CD38 inhibitor and enteroendocrine-pancreatic hormone pathway modulator). In certain embodiments, the CD38 inhibitor and the enteroendocrine-pancreatic hormone pathway modulator are administered simultaneously (i.e., wherein the administration of the CD38 inhibitor and enteroendocrine-pancreatic hormone pathway modulator occur over the same period of time). In certain embodiments, the CD38 inhibitor and the enteroendocrine-pancreatic hormone pathway modulator are administered sequentially. For example, in certain embodiments, the CD38 inhibitor is administered before the enteroendocrine-pancreatic hormone pathway modulator and, in other embodiments, the CD38 inhibitor is administered after the enteroendocrine-pancreatic hormone pathway modulator.

[0118] In certain embodiments, the CD38 inhibitor and the enteroendocrine-pancreatic hormone pathway modulator are administered to the subject as separate formulations. In certain embodiments, the CD38 inhibitor and the enteroendocrine-pancreatic hormone pathway modulator are administered to the subject as a single formulation.

[0119] In embodiments, the formulation(s) comprising the CD38 inihibitor and the enteroendocrine-pancreatic hormone pathway modulator are pharmaceutical composition(s). Pharmaceutically acceptable excipient, carrier, adjuvant, stabilizer, diluent, etc. to be included are determined by the composition being administered and by the method of administering the composition. There are a wide variety of suitable formulations of pharmaceutical composition including optional pharmaceutically acceptable carriers, excipients, stabilizers, etc. Acceptable carriers or diluents for therapeutic use are well known in the pharmaceutical art, and are described, for example, in Remington's Pharmaceutical Sciences, 18th Ed., Mack Publishing Co., Easton, Pa. (1990).

[0120] Pharmaceutical compositions suitable for parenteral administration, such as, for example, by intraarticular (in the joints), intravenous, intramuscular, intradermal, intraperitoneal, and subcutaneous routes, include aqueous and non-aqueous, isotonic sterile injection solutions, which can contain antioxidants, buffers, bacteriostats, and solutes that render the formulation isotonic with the blood of the intended recipient, and aqueous and non-aqueous sterile suspensions that can include suspending agents, solubilizers, thickening agents, stabilizers, and preservatives. Compositions can be administered, for example, by intravenous infusion, orally, topically, intraperitoneally, intravesically or intrathecally.

[0121] As used herein, the term “pharmaceutically acceptable salts” refers to salts that retain the desired biological activity of the above-identified compounds and exhibit minimal or no undesired toxicological effects. Examples of such salts include, but are not limited to acid addition salts formed with inorganic acids (for example, hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, nitric acid, and the like), and salts formed with organic acids such as acetic acid, oxalic acid, tartaric acid, succinic acid, malic acid, ascorbic acid, benzoic acid, tannic acid, pamoic acid, alginic acid, polyglutamic acid, naphthalenesulfonic acid, naphthalenedisulfonic acid, and polygalacturonic acid. Non-toxic pharmaceutical base addition salts include salts of bases such as sodium, potassium, calcium, ammonium, and the like. In certain embodiments, the pharmaceutically acceptable salt is a sodium salt. In certain embodiments, the pharmaceutically acceptable salt is a potassium salt. Those skilled in the art will recognize a wide variety of non-toxic pharmaceutically acceptable addition salts.

[0122] In certain embodiments, the CD38 inhibitor and / or the enteroendocrine-pancreatic hormone pathway modulator is administered subcutaneously. In certain embodiments, the CD38 inhibitor and / or the enteroendocrine-pancreatic hormone pathway modulator is administered intravenously. In certain embodiments, the CD38 inhibitor and / or the enteroendocrine-pancreatic hormone pathway modulator is administered orally.

[0023] The CD38 inhibitor and the enteroendocrine-pancreatic hormone pathway modulator can be administered in therapeutically effective amounts as determined as appropriate for a particular subject by one of ordinary skill in the art. In certain embodiments, the therapeutically effectie amount of the CD38 inhibitor is in the range of 0.01 to 300 mg / kg per day, e.g., 0.01 to 100 mg / kg per day. In certain embodiments, the therapeutically effective amount of the CD38inhibitor is less than 1% of the clinically-established therapeutic amount. In certain embodiments, the therapeutically effective amount of the enteroendocrine-pancreatic hormone pathway modulator is in the range of 0.01 to 300 mg / kg per day, e.g., in the range of 0.01 to 100 mg / kg per day. In certain embodiments, the therapeutically effective amount of the enteroendocrine-pancreatic hormone pathway modulator is less than 1% of the clinically- established therapeutic amount.

[0124] The treating or preventing a metabolic disorder or disease in a subject caused by or characterized by abnormal glucose metabolism can result in a variety of changes in the subject, such as reduced triglyceride, total cholesterol, low density lipoprotein (LDL) cholesterol, and / or non-fasted glucose levels relative to a baseline level. Baseline levels of triglyceride, total cholesterol, LDL cholesterol, and / or glucose can be measured prior to the adminstration of the CD38 inhibitor and the enteroendocrine-pancreatic hormone pathway modulator to the subject. Accordingly, in certain embodiments, the administration of the CD38 inhibitor and the enteroendocrine-pancreatic hormone pathway modulator to the subject reduces triglyceride, total cholesterol, low density lipoprotein (LDL) cholesterol, and / or non-fasted glucose levels relative to a baseline level as measured prior to the administration of the CD38 inhibitor and the enteroendocrine-pancreatic hormone pathway modulator to the subject; and wherein the administration to the subject improves the reduction of triglyceride, total cholesterol, LDL cholesterol, and / or non-fasted glucose levels relative to administration of the enteroendocrine- pancreatic hormone pathway modulator alone to the subject.

[0125] The treating or preventing a metabolic disorder or disease in a subject caused by or characterized by abnormal nutrient (e.g., glucose) metabolism can also result in reduced reduced fat mass, preserved lean body mass and / or muscle function, improved insulin sensitivity, and / or improved insulin secretion. Accordingly, in certain embodiments, the administration of the CD38 inhibitor and the enteroendocrine-pancreatic hormone pathway modulator to the subject reduces fat mass, preserves lean body mass and / or muscle function, or improves insulin sensitivity and / or insulin secretion relative to a baseline level as measured prior to the administration of the CD38 inhibitor and the enteroendocrine-pancreatic hormone pathway modulator to the subject; and wherein the administration to the subject improves insulin sensitivity and / or insulin secretion relative to administration of the enteroendocrine-pancreatic hormone pathway modulator alone to the subject.

[0126] Therapeutic regimen that fall within the scope of the disclosure may further include lifestyle modifications such as dieting (e.g., reduced calorie diet or calorie restriction), exercising(e.g., increased physical activity), and / or mental health counseling as part of the treatment. In some embodiments, patients are provided with diet, mental health, and / or exercise counseling.

[0127] All of the references cited herein are incorporated by reference. Aspects of the disclosure can be modified, if necessary, to employ the systems, functions, and concepts of the above references and application to provide yet further embodiments of the disclosure. These and other changes can be made to the disclosure in light of the detailed description.

[0128] Specific elements of any foregoing embodiments can be combined or substituted for elements in other embodiments. Moreover, the inclusion of specific elements in at least some of these embodiments may be optional, wherein further embodiments may include one or more embodiments that specifically exclude one or more of these specific elements.

[0129] Furthermore, while advantages associated with certain embodiments of the disclosure have been described in the context of these embodiments, other embodiments may also exhibit such advantages, and not all embodiments need necessarily exhibit such advantages to fall within the scope of the disclosure.It is understood that the examples and embodiments described herein are for illustrative purposes only and that various modifications or changes in light thereof will be suggested to persons skilled in the art and are to be incorporated within the spirit and purview of this application and scope of the appended claims.Examples

[0130] While combination obesity therapies that target multiple pathways (e.g., GLP-1 and amylin) may be able to achieve greater (i.e., additive) weight loss efficacy relative to either monotherapy, certain unexpected effects can also be associated with such combinations (e.g., allow for lower dosing of each drug, potential reduction of side effects, etc.). In accordance with the disclosure, however, a combination comprising a CD38 inhibitor with one or more of a GLP-1 R agonist, such as semaglutide or liraglutide, or multi-targeted agonists (e.g., dual or triple GLP-1 R / GIP / GCG agonists such as tirzepatide, retatrutide, etc.), can lead to unexpected synergistic effects and improved overall metabolic health with reduced side effects.

[0131] EXAMPLE - Animal Model Assessment of Combination Therapy

[0132] A preclinical animal model is used to assess the efficacy of therapies comprising the combination of test articles (i.e., incretin mimetic(s) and CD38 inhibitor(s)). Briefly, mouse and / or rat diet-induced obesity models are used to evaluate and determine the beneficialeffects of a combination dosing regimen of active agents, relative to each active agent when given as single dose therapy (i.e., monotherapy). Male C57BL / 6 mice or rats (e.g., Sprague- Dawley or Wistar), are used and fed a high-fat diet for >14 weeks to induce obesity (e.g., a mean starting weight ~46g for diet-induced obese mice), mild hyperglycemia, and impaired glucose tolerance. Animals are habituated to dosing procedures with placebo for 1-2 weeks before study onset. For monotherapy controls, an incretin mimetic (e.g., semaglutide (daily), tirzepatide (once every 3 days), or liraglutide (twice daily)) is administered by subcutaneous injection at a dose of 1 - 30 nmol / kg. A small molecule CD38 inhibitor, e.g., an agent in accordance with the disclosure, is administered by oral gavage once ortwice / day in a typical range of 5 - 50 mg / kg. For assessment of combination studies, both agents are administered concurrently, and / or can also be sequentially administered in series (e.g., administer CD38 inhibitor after 1 week of GLP-1R agonist administration). Furthermore, the combination regimen can include sub-maximal dose administration of either the incretin mimetic or the CD38 inhibitor to avoid excessive weight loss, to limit muscle loss or adverse effects, and / or to ensure animal welfare.

[0133] Efficacy of combination therapy is evaluated by measuring various criteria related to body mass and / or metabolism. Regular (e.g., daily) measurements of body weight and food intake are made. Body composition is evaluated by known methods including, for example, using EchoMRL Accurate measurement of the effects of the therapy on skeletal muscle mass are evaluated, e.g., using the D3-creatine dilution method. CLAMS (Comprehensive Lab Animal Monitoring System) can be used for metabolic phenotyping of the study animals and enables the measurement of indirect calorimetry, food and water intake, and locomoter activity. Metabolic biomarkers are measured relative to controls (e.g., fasting blood glucose, oral glucose tolerance test, and plasma insulin and leptin, and the like). Biomarkers of inflammation (e.g., CRP, 11-1 , TNF, IL-6, MCP-1 and IL-10) are measured relative to controls. Triglycerides, cholesterol, and / or free fatty acid quantitation are evaluated to provide read-outs of efficacy. Histopathological methods of fresh or frozen tissue sections and / or cultured cells are used to evaluate fat content using dyes that specifically stain neutral lipids and triglycerides (e.g., lysochrome diazo dyes, such as Oil Red O staining).

[0134] Endpoint measurements are made. Percent body weight loss is compared to baseline and vehicle controls. Measurement is made of food intake and fat mass, with a relative reduction of either or both is associated with effective treatment. Measuring a relativereduction of skeletal muscle mass loss, and / or preservation of skeletal muscle mass is associated with effective treatment. Biomarkers are measured, with either or both of an improvement in one or more metabolic biomarker(s), and / or a reduction in one or more biomarker(s) associated with effective treatment. ANOVA with appropriate post hoc tests are used to determine statistical significance of comparisons across study groups.

[0135] References:

[0136] John, L.M., et aL, “Preclinical Weight Loss Efficacy of AM833 in Combination With Semaglutide in Rodent Models of Obesity” (2021 ) J Endocrine Society 5:supplement_1 .

[0137] Morningstar, M., et aL, “Novel cannabinoid receptor 1 inverse agonist CRB-913 enhances efficacy of tirzepatide, semaglutide, and liraglutide in the diet-induced obesity mouse model” (2023) Obesity 31 :2676.

[0138] Falk, S., et aL, “GLP-1 and nicotine combination therapy engages hypothalamic and mesolimbic pathways to reverse obesity” (2023) Cell Reports 42,(5): 112466.

[0139] Wimer, L., et aL, “The D3-creatine dilution method non-invasively measures muscle mass in mice” (05 June 2023) Aging Cell 22:e13897.

Claims

CLAIMSWe Claim:

1. A method of treating or preventing a metabolic disorder or disease in a subject caused by or characterized by abnormal nutrient metabolism, the method comprising: administering to the subject a therapeutically effective amount of a cyclic ADP ribose hydrolase (CD38) inhibitor and a therapeutically effective amount of an enteroendocrine-pancreatic hormone pathway modulator.

2. The method of claim 1 , wherein the metabolic disorder or disease is obesity, Parkinson’s disease, type 2 diabetes, kidney disease, cardiovascular disease, or metabolic liver disease.

3. The method of claim 1 or claim 2, wherein the CD38 inhibitor is 4-(((1r,4r)-4-(2- methoxyethoxy)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one.

4. The method of claim 1 or claim 2, wherein the CD38 inhibitor is a flavonoid (e.g., luteolinidin, kuromanin, delphinidin, pelargonidin, malvidin, quercetagetinidin, peonidin, cyanidin, diosmetinidin, petunidin, fisetinidin, luteolin, myricetin, quercetin, robinetin, or quercetagetin).

5. The method according to claim 1 or claim 2, wherein the CD38 inhibitor is6-(1H-lmidazol-1-yl)-4-methyl-N-(1-(methylsulfonyl)piperidin-4-yl)picolinamide;N-(1 -(Ethylsulfonyl)piperidin-4-yl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;N-(1-(cyclopropylsulfonyl)piperidin-4-yl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;6-(1H-lmidazol-1-yl)-N-(1-( (2-methoxyethyl)sulfonyl)piperidin-4-yl)-4- methylpicolinamide;N-(1-(Cyclohexylsulfonyl)piperidin-4-yl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(1-(propylsulfonyl)piperidin-4-yl)picolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(1-(methylsulfonyl)azetidin-3-yl)picolinamide;N-(4,4-Difluorocyclohexyl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(tetrahydro-2H-pyran-3-yl)picolinamide;N-(1-Acetylpiperidin-4-yl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(piperidin-4-yl)picolinamide;N-Cyclobutyl-6-(1H-imidazol-1-yl)-4-methylpicolinamide;N-(1-Butyrylpiperidin-4-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(1-(N-methylsulfamoyl)piperidin-4-yl)picolinamide;6-(1H-lmidazol-1-yl)-4-methoxy-N-(1-(methylsulfonyl)piperidin-4-yl)picolinamide;6-(1H-lmidazol-1-yl)-N-(1-(methylsulfonyl)piperidin-4-yl)picolinamide;N-(1-(N,N-Dimethylsulfam oyl)piperidin-4-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(1-(2-morpholinoacetyl)piperidin-4-yl)picolinamide;6-(1H-lmidazol-1-yl)-N-(1-(3-methoxypropanoyl)piperidin-4-yl)-4-methylpicolinamide;N-(1-(Dimethylcarbamoyl)piperidin-4-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(1-(methylcarbamoyl)piperidin-4-yl)picolinamide;N-(1,1-Dioxidotetrahydrothiophen-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;N-(2,2-Dimethyltetrahydro-2H-pyran-4-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;N-(4,4-Difluorotetrahydro-2H-pyran-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;N-(5,5-Difluorotetrahydro-2H-pyran-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;N-(3,3-Dimethyltetrahydro-2H-pyran-4-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;N-(8-Oxabicyclo[3.2.1]octan-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;N-(6,6-Dimethyltetrahydro-2H-pyran-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(2-methyltetrahydro-2H-pyran-4-yl)picolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(tetrahydro-2H-pyran-4-yl)picolinamide;N-Cycloheptyl-6-(1H-imidazol-1-yl)-4-methylpicolinamide;N-(3,3-Difluorocyclopentyl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;N-(1,1-Dioxidotetrahydro-2H-thiopyran-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;(S)-6-(1H-lmidazol-1-yl)-4-methyl-N-( tetrahydrofuran-3-yl)picolinamide;(S)-6-(1H-lmidazol-1-yl)-4-methyl-N-(pyrrolidin-3-yl)picolinamide hydrochloride;(R)-6-(1H-lmidazol-1-yl)-4-methyl-N-(tetrahydrofuran-3-yl)picolinamide;tert-Butyl (R)-3-( 6-(1 H-imidazol-1-yl)-4-methylpicolinamido)pyrrolidine-1 -carboxylate;(R)-6-(1H-lmidazol-1-yl)-4-m ethyl-N-(tetrahydro-2H-pyran-3-yl)picolinamide;(S)-6-(1H-lmidazol-1-yl)-4-m ethyl-N-(tetrahydro-2H-pyran-3-yl)picolinamide; tert-Butyl (S)-3-( 6-(1 H-imidazol-1 -yl)-4-methylpicolinamido)piperidine-1 -carboxylate;(S)-6-(1H-lmidazol-1-yl)-4-methyl-N-(piperidin-3-yl)picolinamide dihydrochloride; tert-Butyl (R)-3-(6-(1H-imidazol-1-yl)-4-methylpicolinamido)piperidine-1 -carboxylate;(S)-6-(1H-lmidazol-1-yl)-4-methyl-N-(1-(methylsulfonyl)piperidin-3-yl)picolinamide;(R)-6-(1H-lmidazol-1-yl)-4-methyl-N-(piperidin-3-yl)picolinamide dihydrochloride;(R)-6-(1H-lmidazol-1-yl)-4-methyl-N-(pyrrolidin-3-yl)picolinamide dihydrochloride;(R)-6-(1H-lmidazol-1-yl)-4-methyl-N-(1-( methylsulfonyl)pyrrolidin-3-yl)picolinamide;(R)-6-(1H-lmidazol-1-yl)-4-methyl-N-(1-( methylsulfonyl)piperidin-3-yl)picolinamide;(S)-N-(1 -Dioxidotetrahydrothiophen-3-yl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;(R)-6-(1H-lmidazol-1-yl)-4-m ethyl-N-( 1-m ethyl-2-oxopiperidin-3-yl)picolinamide;(R)-N-(1 , 1 -Dioxidotetrahydro-2H-thiopyran-3-yl)-6-(1 H-imidazol-1 -yl)-4- methylpicolinamide;(R)-6-(1H-lmidazol-1-yl)-4-methyl-N-(2-oxopiperidin-3-yl)picolinamide;(R)-6-(1H-lmidazol-1-yl)-4-methyl-N-(1-methylpiperidin-3-yl)picolinamide;(S)-6-(1H-lmidazol-1-yl)-4-methyl-N-(2-oxopiperidin-3-yl)picolinamide;2-(1H-lmidazol-1-yl)-6-methyl-N-(1-(methylsulfonyl)piperidin-4-yl)pyrimidine-4- arboxamide;(R)-6-(1 H-imidazol-1 -yl)-N-( tetrahydro-2H-pyran-3-yl)-4-(trifluoromethyl)picolinamide;(R)-N-(2,6-Dioxopiperidin-3-yl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;(R)-N-(6,6-Dimethyltetrahydro-2H-pyran-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;(R)-N-(5,5-Difluorotetrahydro-2H-pyran-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;(R)-N-(5,5-Difluorotetrahydro-2H-pyran-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;(R)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(1 H-imidazol-1 -yl)-6- methyl pyri midi ne-4- carboxamide;(R)-2-(1 H-lmidazol-1-yl)-6-m ethyl-N-( tetrahydro-2H-pyran-3-yl)pyrimidine-4- carboxamide;(S)-N-(4,4-Difluorotetrahydro-2H-pyran-3-yl)-6-(1 H-imidazol-1-yl)-4-methylpicolinamide;(R)-N-(4,4-Difluorotetrahydro-2H-pyran-3-yl)-6-(1H-imidazol-1-yl)-4-methylpicolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(1-( ( tetrahydrofuran-3-yl)sulfonyl)piperidin-4- yl)picolinamide;2-(1H-lmidazol-1-yl)-N-(1-(methylsulfonyl)piperidin-4-yl)pyrimidine-4-carboxamide;(R)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(1 H-imidazol-1 -yl)pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(1-(methylsulfonyl)piperidin-4-yl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;(R)-2-(1 H-lmidazol-1-yl)-N-(tetrahydro-2H-pyran-3-yl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;(R)-N-(1 , 1 -Dioxidotetrahydrothiophen-3-yl)-2-(1 H-imidazol-1 -y I )-6- (trifl uoro methyl )pyri m id i ne-4-carboxa m ide ;(R)-N-(1 , 1 -Dioxidotetrahydrothiophen-3-yl)-6-(1 H-imidazol-1 -y I )-4- (trifluoromethyl)picolinamide;6-(1H-lmidazol-1-yl)-3-methyl-N-(1-(methylsulfonyl)piperidin-4-yl)picolinamide;(R)-2-(1 H-lmidazol-1-yl)-N-(tetrahydro-2H-pyran-3-yl)pyrimidine-4-carboxamide;(R)-6-(1 H-lmidazol-1-yl)-3-m ethyl-N-( tetrahydro-2H-pyran-3-yl)picolinamide;6-(1H-lmidazol-1-yl)-N-(1-(methylsulfonyl)piperidin-4-yl)-4-(trifluoromethyl)picolinamide;(R)-6-(1 H-lmidazol-1-yl)-4-methyl-N-(1-(oxetan-3-yl)piperidin-3-yl)picolinamide;(S)-N-(1 ,1-Dioxidotetrahydro-2H-thiopyran-3-yl)-6-(1 H-imidazol-1-yl)-4- methylpicolinamide;(S)-6-(1H-lmidazol-1-yl)-4-methyl-N-(1-methyl-2-oxopiperidin-3-yl)picolinamide;(R)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;6-(1H-lmidazol-1-yl)-4-methyl-N-(1-(oxetan-3-ylsulfonyl)piperidin-4-yl)picolinamide;4-(((1 r,4r)-4-hydroxycyclohexyl)amino)-1 -methyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;4-(((1 r,4r)-4-aminocyclohexyl)amino)-1 -methyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;4-(((1s,4s)-4-aminocyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;4-(((1 S,2S)-2-aminocyclohexyl)amino)-1 -methyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;4-(((1 R,2R)-2-aminocyclohexyl)amino)-1 -methyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;4-((3-aminocyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;1-methyl-4-(piperidin-4-ylamino)-6-(thiazol-5-yl)quinolin-2(1 H)-one;4-(((1r,4r)-4-(aminomethyl)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)- one;4-(((1s,4s)-4-(aminomethyl)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1 H)- one;4-((((1r,4r)-4-(aminomethyl)cyclohexyl)methyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin- 2(1 H)-one;4-((4-aminophenyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one;4-((4-(aminomethyl)phenyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;4-(((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-1 -methyl-6-(1 H-pyrazol-4-yl)quinolin- 2(1 H)-one;8-(((1 r,4r)-4-hydroxy-4-methylcyclohexyl)amino)-2-(1 H-imidazol-1 -yl)-5-methylpyrido[3,2- d] pyri m id i n-6(5H )-o ne ;2-(1 H-imidazol-1 -yl)-5-methyl-8-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrido[3, 2- d] pyri m id i n-6(5H )-o ne ;2-(1 H-imidazol-1 -yl)-6-methyl-N-((1 r,4r)-4-((2,2,2- trifluoroethyl)amino)cyclohexyl)pyrimidine-4-carboxamide;N-((1r,4r)-4-((2,2-difluoroethyl)amino)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methyl- pyrimidine-4-carboxamide;6-cyclopropyl-N-((1r,4r)-4-((2,2-difluoroethyl)amino)cyclohexyl)-2-(1 H-imidazol-1 - yl )pyri m id i ne-4-carboxa m ide ;6-methyl-2-(1-methyl-1H-imidazol-5-yl)-N-((1r,4r)-4-((2,2,2- trifluoroethyl)amino)cyclohexyl)pyrimidine-4-carboxamide;6-methyl-2-(thiazol-5-yl)-N-((1r,4r)-4-((2,2,2-trifluoroethyl)amino)cyclohexyl)pyrimidine-4- carboxamide;6-methyl-2-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-( (2,2,2- trifluoroethyl)amino)cyclohexyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-6-methyl-N-((1 r,4r)-4-(methyl(2,2,2- trifluoroethyl)amino)cyclohexyl)pyrimidine-4-carboxamide;N-((1r,4r)-4-((2,2-difluoroethyl)amino)cyclohexyl)-6-methyl-2-(thiazol-5-yl)pyrimidine-4- carboxamide;N-((1 r,4r)-4-((2-fluoroethyl)amino)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methylpyrimidine-4- carboxamide;N-((1 r,4r)-4-(3,3-difluoropyrrolidin-1 -yl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methyl- pyrimidine-4-carboxamide;N-((1s,4s)-4-(3,3-difluoropyrrolidin-1-yl)cyclohexyl)-2-(1 H-imidazol-1 -yl )-6- methyl - pyrimidine-4-carboxamide;N-((1 s,4r)-4-((S)-3-fluoropyrrolidin-1 -yl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methyl- pyrimidine-4-carboxamide;N-( (1r,4r )-4-( (R)-3-fluoropyrrolidin-1-yl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methyl- pyrimidine-4-carboxamide;6-methyl-2-(1 H-pyrazol-4-yl)-N-((1 r,4r)-4-((2,2,2- trifluoroethyl)amino)cyclohexyl)pyrimidine-4-carboxamide;N-((1r,4r)-4-((2,2-difluoroethyl)amino)cyclohexyl)-6-methyl-2-(1H-pyrazol-4-yl)pyrimidine- 4-carboxamide;4-cyclopropyl-N-((1r,4r)-4-((2,2-difluoroethyl)amino)cyclohexyl)-6-(1 H-imidazol-1 - yl)picolinamide;N-((1 r,4r)-4-(ethylamino)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methyl30 pyrimidine-4- carboxamide;4-cyclopropyl-6-(1 H-imidazol-1 -yl )-N-((1 r,4r)-4-((2,2,2- trifluoroethyl)amino)cyclohexyl)picolinamide;2-(1 H-imidazol-1 -yl)-6-methyl-N-((1 r,4r)-4-((1 , 1 ,1 -trifluoro-2-methylpropan-2- yl)amino)cyclohexyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-6-methyl-N-((1 S,4r)-4-(((S)-1 , 1 ,1 -trifluoropropan-2- yl)amino)cyclohexyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-6-methyl-N-((1 R,4r)-4-(((R)-1 , 1 ,1 -trifluoropropan-2- yl)amino)cyclohexyl)pyrimidine-4-carboxamide;6-methyl-2-(5-methyl-1 H-imidazol-1 -yl)-N-((1r, 4r)-4-((2, 2,2- trifluoroethyl)amino)cyclohexyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-6-methyl-N-((1 r,4r)-4-(((2,2,2- trifluoroethyl)amino)methyl)cyclohexyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-6-methyl-N-((1 r,4r)-4-((2,2,2- trifluoroethyl)carbamoyl)cyclohexyl)pyrimidine-4-carboxamide;N-((1 r,4r)-4-aminocyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methyl-pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-6-methyl-N-( (1r,4r )-4-( (2,2,2-trifluoroethyl-1,1- d2)amino)cyclohexyl)pyrimidine-4-carboxamide;(Z)-3-(4-methoxyphenyl)-5-((5-nitrothiophen-2-yl)methylene)thiazolidine-2, 4-dione;N5,N6-bis(3-chlorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine;5-chloro-2-hydroxy-N-(naphthalen-1-yl)benzamide;5-(2-aminoethyl)-2-hydroxy-N-(naphthalen-1-yl)benzamide;(E)-5-(2-hydrazineylidenepropyl)-2-hydroxy-N-(6-(2-hydroxycyclopropyl)naphthalen-1- yl)benzamide;5-(2-hydroxy-5-(3-hydroxypropyl)benzamido)-2-naphthoic acid;5-(3-aminopropyl)-2-hydroxy-N-(6-hydroxynaphthalen-1-yl)benzamide;N-(6-aminonaphthalen-1-yl)-2-hydroxy-5-((2-hydroxyethyl)thio)benzamide;N-(6-fluoronaphthalen-1-yl)-2-hydroxy-5-((2-hydroxyethyl)amino)benzamide;5-(2-aminoethoxy)-2-hydroxy-N-(6-methoxynaphthalen-1-yl)benzamide;(E)-2-hydroxy-5-(3-hydroxyprop-1-en-1-yl)-N-(6-(methylsulfonamido)naphthalen-1- yl)benzamide;2-hydroxy-N-(6-(hydroxymethyl)naphthalen-1 -yl)-5-(3-hydroxyprop-1 -yn-1 -yl)benzamide;(E)-2-(5-(5-(3-aminoprop-1-en-1-yl)-2-hydroxybenzamido)naphthalen-2-yl)acetic acid;5-(3-fluoropropyl)-2-hydroxy-N-(6-(trifluoromethyl)naphthalen-1-yl)benzamide;5-(2-hydroxy-5-(2-(hydroxymethyl)cyclopropyl)benzamido)-2-naphthoic acid;5-(2-aminoethyl)-2-hydroxy-4-(2-hydroxyethyl)-N-(naphthalen-1-yl)benzamide;5-(3-aminopropyl)-2-hydroxy-4-(2-hydroxyethoxy)-N-(naphthalen-1-yl)benzamide;5-(3-aminopropyl)-2-hydroxy-4-(2-hydroxyethoxy)-N-(naphthalen-1-yl)benzamide;(E)-2-hydroxy-5-(3-hydroxyprop-1-en-1-yl)-N-(naphthalen-1-yl)-4-(2,2,2- trifluoroethoxy)benzamide;5-(2-aminoethyl)-2-hydroxy-N-(naphthalen-1-yl)benzamide;2-hydroxy-N-(naphthalen-1-yl)-5-(trifluoromethyl)benzamide;(E)-3-(4-hydroxy-3-(naphthalen-1-ylcarbamoyl)phenyl)acrylic acid;5-(2-aminoethyl)-2-hydroxy-N-(1,2,3,4-tetrahydronaphthalen-1-yl)benzamide;5-(3-aminopropyl)-N-(2,3-dihydro-1H-inden-1-yl)-2-hydroxybenzamide;5-(3-aminopropyl)-N-(2,3-dihydro-1H-inden-1-yl)-2-hydroxy-4-(2- hydroxyethoxy)benzamide;(E)-2-hydroxy-5-(3-hydroxyprop-1-en-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1- yl)benzamide;5-chloro-2-hydroxy-N-(1,2,3,4-tetrahydronaphthalen-1-yl)benzamide;2-hydroxy-N-(naphthalen-1-yl)-5-(trifluoromethyl)benzamide;3-(4-hydroxy-3-(naphthalen-1-ylcarbamoyl)phenyl)propanoic acid;2-hydroxy-N-(naphthalen-1-yl)-5-(2-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4- d]imidazol-4-yl)pentanamido)ethyl)benzamide;5-chloro-2-hydroxy-N-(naphthalen-1-yl)benzamide;S-chloro-S-CS-chlorophenylJ-S.IO-dihydro-II^.SJoxadiazoloP'^'^.ejpyrazinop.S- b]quinoxaline;(Z)-3-(4-methoxyphenyl)-5-((5-nitrothiophen-2-yl)methylene)-2-thioxothiazolidin-4-one;3-(1H-imidazol-1-yl)-N-(1,4,4-trimethylpyrrolidin-3-yl)benzamide;N-(1-ethylpiperidin-3-yl)-3-(1H-imidazol-1-yl)benzamide;(S)-N-(1 -ethyl piperid in-3-yl )-3-(1 H-imidazol-1 -yl)benzamide;N-(1 -ethyl-4,4-di methyl pyrrol idin-3-yl)-3-(1 H-imidazol-1-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(1-isopropylpiperidin-4-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)benzamide;N-(3-(hydroxymethyl)bicyclo[2.2.1]heptan-2-yl)-3-(1 H-imidazol-1 -yl)benzamide;N-(4-(hydroxymethyl)pyridin-3-yl)-3-(1 H-imidazol-1-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-octahydroindolizin-1 -yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(pyrrolidin-3-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(4-methylpiperidin-3-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(4-methylpiperidin-3-yl)benzamide dihydrochloride;3-(1 H-imidazol-1 -yl)-N-(2-methylpiperidin-3-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(3-methylpiperidin-4-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(3-methylpiperidin-4-yl)benzamide dihydrochloride;N-(3,4-difluorophenyl)-3-(1 H-imidazol-1 -yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(piperidin-3-yl)benzamide;2-fluoro-N-(4-fluorophenyl)-5-(1 H-imidazol-1 -yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(1-propionylpyrrolidin-3-yl)benzamide;N-(1 -azabicyclo[3.2.1 ]octan-5-yl)-3-(1 H-imidazol-1 -yl)benzamide;N-(4-fluorotetrahydrofuran-3-yl)-3-(1 H-imidazol-1 -yl)benzamide;N-((3S,4S)-4-fluorotetrahydrofuran-3-yl)-3-(1 H-imidazol-1-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(2-methyltetrahydrofuran-3-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-((2S,3S)-2-methyltetrahydrofuran-3-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(6-oxaspiro[3.4]octan-2-yl)benzamide;N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-(1 H-imidazol-1 -yl)benzamide;N-(4-(hydroxymethyl)cyclohexyl)-3-(1 H-imidazol-1 -yl)benzamide;N-((1r,4r)-4-(hydroxymethyl)cyclohexyl)-3-(1 H-imidazol-1 -yl)benzamide;N-(1 -ethyl piperidin-4-yl)-3-(1 H-imidazol-1-yl)benzamide;N-(2-hydroxycyclohexyl)-3-(1 H-imidazol-1-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(4-methylpiperidin-4-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(4-methylpiperidin-4-yl)benzamide dihydrochloride;(S)-3-(1 H-imidazol-1 -yl)-N-(piperidin-3-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(piperidin1-3-yl)benzamide dihydrochloride;N-(azetidin-3-yl)-3-(1 H-imidazol-1 -yl)benzamide;N-(azetidin-3-yl)-3-(1 H-imidazol-1 -yl)benzamide dihydrochloride;2-fluoro-N-(3-fluorophenyl)-5-(1 H-imidazol-1 -yl)benzamide;N-cyclopentyl-3-(1 H-imidazol-1 -yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(7-methoxybicyclo[3.2.0]heptan-6- yl)benzamide;N-(3,4-dihydroxycyclopentyl)-3-(1 H-imidazol-1 -yl)benzamide;N-((3R,4S)-3,4-dihydroxycyclopentyl)-3-(1 H-imidazol-1 -yl)benzamide;N-(1-(tert-butyl)piperidin-4-yl)-3-(1 H-imidazol-1 -yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(1-oxidotetrahydro-2H-thiopyran-4-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(2, 2, 5, 5-tetramethyltetrahydrofuran-3-yl)benzamide;N-((1 s,4s)-4- (hydroxymethyl)cyclohexyl)-3-(1 H-imidazol-1 -yl)benzamide;N-(1-(hydroxymethyl)cyclopentyl)-3-(1 H-imidazol-1 -yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(pyrrolidin-3-yl)benzamide dihydrochloride;3-(1 H-imidazol-1 -yl)-N-(2-methylpiperidin-4-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(2-methylpiperidin-3-yl)benzamide dihydrochloride;3-(1 H-imidazol-1 -yl)-N-(piperidin4-yl)benzamide;(S)-3-(1 H-imidazol-1 -yl)-N-(piperidin-3-yl)benzamide dihydrochloride;N-(8-azabicyclo[3.2.1]octan-3-yl)- 3-(1 H-imidazol-1 -yl)benzamide;N-(8-azabicyclo[3.2.1]octan-3-yl)-3-(1 H-imidazol-1 -yl)benzamide dihydrochloride;N-cyclopentyl-2-fluoro-5-(1 H-imidazol-1 -yl)benzamide;methyl 1-(3-(1 H-imidazol-1-yl)benzamido)cyclopentane-1 -carboxylate;N-(4-hydroxy-1 -methylcyclohexyl )-3-(1 H-imidazol-yl)benzamide;3-(1H-imidazol-1-yl)-N-(5-oxa-2-azaspiro[3.4]octan-7-yl)benzamide;N-(2-(hydroxymethyl)bicyclo[2.2.2]octan-2-yl)-3-(1 H-imidazol-1-yl)benzamide; methyl 1-(3-(1 H-imidazol-1-yl)benzamido)-3-hydroxycyclobutane-1 -carboxylate; methyl (1s,3s)-1-(3-(1H-imidazol-1-yl)benzamido)-3-hydroxycyclobutane-1 -carboxylate;3-(1H-imidazol-1-yl)-N-(spiro[3.3]heptan-1-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(2-methoxycyclohexyl)benzamide;3-(1 H-imidazol-1 -yl)-N-((1 R,2R)-2-methoxycyclohexyl)benzamide;N-(2-(hydroxymethyl)-2-methylcyclopentyl)-3-(1 H-imidazol-1 -yl)benzamide;3-(1 H-imidazol-1 -yl)-N-phenyl benzamide;N-(1,1-dioxidotetrahydro-2H-thiopyran-3-yl)-3-(1 H-imidazol-1 -yl)benzamide;N-(4,6-dimethylpyridin-2-yl)-3-(1 H-imidazol-1 -yl)benzamide;2-fluoro-5-(1 H-imidazol-1 -yl)-N-phenylbenzamide;N-(3,3-dichlorocyclobutyl)-3-(1 H-imidazol-1 -yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(1-isobutyrylpiperidin-4-yl)benzamide;N-(1-acetylpiperidin-4-yl)-3-(1H-imidazol-1-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(2-isopropyltetrahydro-2H-pyran-4-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(1-isopropyl-4-methyl pyrrol idin-3-yl)benzamide;N-(4-ethyltetrahydro-2H-pyran-4-yl)-3-(1 H-imidazol-1 -yl)benzamide;N-(2-(hydroxymethyl)cyclohexyl)- 3-(1 H-imidazol-1 -yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(2-methylpiperidin-4-yl)benzamide dihydrochloride;3-(1 H-imidazol-1 -yl)-N-(piperidin4-yl)benzamide dihydrochloride;2-fluoro-N-(2-fluorophenyl)-5-(1 H-imidazol-1 -yl)benzamide;N-cyclohexyl-2-fluoro-5-(1 H-imidazol-1 -yl)benzamide;3-(1H-imidazol-5-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide;N-(1-(4-methoxyphenyl)cyclopentyl)-3-(4H-1 ,2,4-triazol-4-yl)benzamide;2-bromo-N-(pyridin-3-yl)-5-(4H-1,2,4-triazol-4-yl)benzamide;2-bromo-N-(4-bromophenyl)-5-(4H-1 ,2,4-triazol-4-yl)benzamide;N-( 4-chlorophenyl)-3-(4H-1 ,2,4-triazol-4-yl)benzamide;2-chloro-N-cyclopentyl-5-(4H-1 ,2,4-triazol-4-yl)benzamide;N-(4-bromophenyl)-2-chloro-5-(4H-1,2,4-triazol-4-yl)benzamide;N-(tetra hyd ro-2H- pyra n-4-yl )-3-(4H - 1 , 2 ,4-triazol -4-yl )be nza m ide ;N-(1-(2-methoxyphenyl)cyclopentyl)-3-(4H-1 ,2,4-triazol-4-yl)benzamide;2-bromo-N-(pyridin-4-yl)-5-(4H-1,2,4-triazol-4-yl)benzamide;2-bromo-N-cyclohexyl-5-(4H-1 ,2,4-triazol-4-yl)benzamide;N-(1-(2-fluorophenyl)cyclopentyl)-3-(4H-1,2,4-triazol-4-yl)benzamide;2-chloro-N-cyclooctyl-5-(4H-1 ,2,4-triazol-4-yl)benzamide;N-cycloheptyl-3-(4H-1,2,4-triazol-4-yl)benzamide;N-(2-(benzyloxy)cyclopentyl)-3-(4H-1 ,2,4-triazol-4-yl)benzamide;N-((1 R,2R)-2-(benzyloxy)cyclopentyl)-3-(4H-1 ,2,4-triazol-4-yl)benzamide;N-(1-(3-methoxyphenyl)cyclopentyl)-3-(4H-1 ,2,4-triazol-4-yl)benzamide;2-bromo-N-cycloheptyl-5-(4H-1,2,4-triazol-4-yl)benzamide;N-(1 -( 4-methox yphenyl)cyclohexyl)-3-(4H-1 ,2,4-triazol-4-yl)benzamide;N-(4-methylpyridin-2-yl)-3-(4H-1 ,2,4-triazol-4-yl)benzamide;N-(4-fluorophenyl)-3-(4H-1 ,2,4-triazol-4-yl)benzamide;2-chloro-N-cycloheptyl-5-(4H-1 ,2,4-triazol-4-yl)benzamide;2-bromo-N-(5-bromo-6-methylpyridin-2-yl)-5-(4H-1 ,2,4-triazol-4-yl)benzamide;2-bromo-N-(4-fluorophenyl)-5-(4H-1,2,4-triazol-4-yl)benzamide;2-bromo-N-phenyl-5-(4H-1,2,4-triazol-4-yl)benzamide;2-chloro-N-(4-iodophenyl)-5-(4H-1 ,2,4-triazol-4-yl)benzamide;N-(pyrid i n-3-yl )-3-(4H - 1 , 2 ,4-triazol -4-yl )be nza m ide ;N - ( py r i d i n-4-yl )-3-(4H - 1 , 2 ,4-triazol -4-yl )be nza m ide ;N-( 4-bromophenyl)-3-(4H-1 ,2,4-triazol-4-yl)benzamide;2-chloro-N-(4-methylpyridin-2-yl)-5-(4H-1 ,2,4-triazol-4-yl)benzamide;2-chloro-N-(2,2,6,6-tetramethylpiperidin-4-yl)-5-(4H-1,2,4-triazol-4-yl)benzamide;2-chloro-N-phenyl-5-(4H-1 ,2,4-triazol-4-yl)benzamide;2-chloro-N-cyclohexyl-5-(4H-1 ,2,4-triazol-4-yl)benzamide;N-(1-(3-fluorophenyl)cyclopentyl)-3-(4H-1,2,4-triazol-4-yl)benzamide;2-chloro-N-(1 -( 4-chlorophenyl)cyclobutyl)-5-(4H-1 ,2,4-triazol-4-yl)benzamide;2-bromo-N-cyclopentyl-5-(4H-1,2,4-triazol-4-yl)benzamide;2-bromo-N-(2-chloro-4-iodophenyl)-5-(4H-1 ,2,4-triazol-4-yl)benzamide;2-bromo-N-(4-methylpyridin-2-yl)-5-(4H-1 ,2,4-triazol-4-yl)benzamide;N-(1-(4-chlorophenyl)cyclobutyl)-3-(4H-1,2,4-triazol-4-yl)benzamide;2-chloro-N-(pyridin-2-yl)-5-(4H-1,2,4-triazol-4-yl)benzamide;N-(5-bromo-6-methylpyridin-2-yl)-2-chloro-5-(4H-1 ,2,4-triazol-4-yl)benzamide;2-chloro-N-(2-iodophenyl)-5-(4H-1,2,4-triazol-4-yl)benzamide;N-(5-bromopyridin-2-yl)-2-chlorol-5-(4H-1,2,4-triazol-4-yl)benzamide;N-(4-(2-hydroxyethyl)phenyl)-3-(1 H-imidazol-1 -yl)benzamide;N-(2-(1 -hydroxyethyl)phenyl)-3-(1 H-imidazol-1 -yl)benzamide;6-(1 H-imidazol-1 -yl)-3-methoxy-N-(pyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(4-iodophenyl)picolinamide;N-(4-bromo-2,5-difluorophenyl)-6-(1 H-imidazol-1 -yl)picolinamide;N-cyclohexyl-6-(1 H-imidazol-1 -yl)picolinamide;4-(difluoromethyl)-6-(1 H-imidazol-1 -yl)-N-(4-(2- methoxyethoxy)cyclohexyl)picolinamide;4-(difluoromethyl)-6-(1 H-imidazol-1 -yl)-N-((1r, 4r)-4-(2- methoxyethoxy)cyclohexyl)picolinamideN-(4-chlorophenyl)-6-(1 H-imidazol-1 -yl)picolinamide;3-fluoro-6-(1 H-imidazol-1-yl)-N-(pyridin-3-yl)picolinamide;4-(1 -hydroxyethyl )-6-(1 H-imidazol-1-yl)-N-(4-(2-methoxyethoxy)cyclohexyl)picolinamide;4-(1 -hydroxyethyl )-6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2- methoxyethoxy)cyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-4-(2-methoxyethoxy)-N-(2-(trifluoromethyl)pyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(2-(trifluoromethyl)pyridin-4-yl)picolinamide;N-(6-fluoropyridin-3-yl)-6-(1 H-imidazol-1 -yl)picolinamide;N-(4-bromophenyl)-6-(1 H-imidazol-1 -yl)picolinamide;N-(4-hydroxycyclohexyl)-6-(1H-imidazol-1-yl)picolinamide;N-((1r,4r)-4-hydroxycyclohexyl)-6-(1 H-imidazol-1 -yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(4-(2-methoxyethoxy)cyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxyethoxy)cyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(3-iodophenyl)picolinamide;5-fluoro-6-(1 H-imidazol-1 -yl)-(pyridin-3-yl)picolinamide;N-(2-fluoropyridin-4-yl)-6-(1 H-imidazol-1 -yl)picolinamide;N-(6-bromopyridin-3-yl)-6-(1 H-imidazol-1 -yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(6-methylpyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-phenylpicolinamide;N-(2,6-dimethylpyridin-4-yl)-6-(1 H-imidazol-1-yl)picolinamide;N-(4-(hydroxymethyl)cyclohexyl)-6-(1 H-imidazol-1 -yl)picolinamide;N-((1s,4s)-4-(hydroxymethyl)cyclohexyl)-6-(1 H-imidazol-1 -yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-methyl-N-(pyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-( 4-(2-methoxyethoxy)cyclohexyl)-4-methylpicolinamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-4-methylpicolinamide;3-amino-6-(1 H-imidazol-1-yl)-(2-(trifluoromethyl)pyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(pyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-3-methyl-N-(pyridin-3-yl)picolinamide;N-(1-(hydroxymethyl)cyclopentyl)-6-(1 H-imidazol-1 -yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-methoxy-N-(pyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-methyl-N-(pyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(6-(2, 2, 2-trifluoroethoxy)pyridin-3-yl)picolinamide;N-(3-chloro-2-methylpyridin-4-yl)-6-(1 H-imidazol-1-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(6-(trifluoromethyl)pyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(2-methoxypyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(5-iodo-6-methylpyridin-2-yl)picolinamide;6-(1 H-imidazol-1 -yl)-5-methyl-N-(pyridin-3-yl)picolinamide;N-(2,6-difluoropyridin-4-yl)-6-(1 H-imidazol-1 -yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(6-methoxypyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-methoxy-N-(4-(2-methoxyethoxy)cyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-4-methoxy-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-4-methoxy-N-(2-(trifluoromethyl)pyridin-4-yl)picolinamide;3-amino-6-(1 H-imidazol-1-yl)-N-(pyridin-4-yl)picolinamide;4-(2-hydroxypropan-2-yl)-6-(1 H-imidazol-1 -yl)-N-(4-(2- methoxyethoxy)cyclohexyl)picolinamide;4-(2-hydroxypropan-2-yl)-6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2- methoxyethoxy)cyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(2-methylpyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(pyridin-2-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(4-methoxycyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)picolinamide;3-amino-N-(2-fluoropyridin-4-yl)-6-(1 H-imidazol-1 -yl)picolinamide;6-(1-methyl-1H-imidazol-5-yl)-N-(6-(trifluoromethyl)pyridin-3-yl)picolinamide;6-(1-methyl-1H-imidazol-5-yl)-N-(pyridin-3-yl)picolinamide;4-methyl-6-(1-methyl-1H-imidazol-5-yl)-N-(pyridin-4-yl)picolinamide;N-(2-oxabicyclo[3.2.0]heptan-6-yl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-((1R,5S,6R)-2-oxabicyclo[3.2.0]heptan-6-yl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;3-chloro-N-phenyl-6-(4H-1,2,4-triazol-4-yl)picolinamide;3-chloro-N-(3-chlorophenyl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-cyclopentyl-6-(4H-1,2,4-triazol-4-yl)picolinamide;3-bromo-N-cyclohexyl-6-(4H-1,2,4-triazol-4-yl)picolinamide;3-bromo-N-(4-methylpyridin-2-yl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-(4-bromophenyl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-(2-iodophenyl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-(octahydroindolizin-8-yl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-((8R,8aR)-octahydroindolizin-8-yl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-cycloheptyl-6-(4H-1,2,4-triazol-4yl)picolinamide;N-cyclohexyl-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-(4-iodophenyl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-(5-bromopyridin-2-yl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;3-bromo-N-phenyl-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-(3-chlorophenyl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;3-bromo-N-(4-iodophenyl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-(4-fluorophenyl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;3-bromo-N-cycloheptyl-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-(4-methylpyridin-2-yl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;3-bromo-N-cyclopentyl-6-(4H-1,2,4-triazol-4-yl)picolinamide; methyl 4-(6-(4H-1 ,2,4-triazol-4-yl)picolinamido)-1 -methyl pyrrol idine-2-carboxylate;methyl (2S,4R)-4-(6-(4H-1,2,4-triazol-4-yl)picolinamido)-1-methylpyrrolidine-2- carboxylate;3-bromo-N-(pyridin-4-yl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;3-chloro-N-(4-chlorophenyl)-6-(4H-1,2,4-triazol-4-yl)picolinamide; ethyl 4-(6-(4H-1 ,2,4-triazol-4-yl)picolinamido)piperidine-1 -carboxylate;N-(pyridin-3-yl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;3-bromo-N-(pyridin-3-yl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-phenyl-6-(4H-1,2,4-triazol-4-yl)picolinamide;3-bromo-N-(4-fluorophenyl)-6-(4H-1,2,4-triazol-4-yl)picolinamide;N-( 4-chlorophenyl)-6-(4H-1 ,2,4-triazol-4-yl)picolinamide;N-(pyridin-4-yl)-6-(4H-l,2,4-triazol-4-yl)picolinamide;6-(thiazol-5-yl)-N-(6-(trifluoromethyl)pyridin-3-yl)picolinamide;N-(2-chlorophenyl)-6-(thiazol-5-yl)picolinamide;N-(4-(2-methoxyethoxy)cyclohexyl)-6-(thiazol-5-yl)picolinamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(thiazol-5-yl)picolinamide;N-(4-(2-hydroxyethyl)phenyl)-6-(1H-imidazol-1-yl)picol inamide;2-(1 H-imidazol-1 -yl)-(spiro[2.5]octan-yl)isonicotinamide;2-(1H-imidazol-1-yl)-N-(2-methylpiperidin-4-yl)isonicotinamide;N-(4-chlorophenyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(piperidin-3-yl)isonicotinamide;N-(bicyclo[4.2.0]octan-7-yl)-2-(1H-imidazol-1-yl)isonicotinamide;N-((1 R,6R,7S)-bicyclo[ 4.2.0]octan-7-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(1 -(hydroxymethyl)cyclooctyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)isonicotinamide;N-(3,3-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(4-methylcyclohexyl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methylcyclohexyl)isonicotinamide;N-(1 -ethyl -6-oxo- 1 ,6-dihydropyridin-3-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(4-(2-methoxyethoxy)cyclohexyl)-6-methyl isonicotinamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-methyl isonicotinamide;N-(2,4-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(6-methoxypyridin-3-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(4-(trifluoromethyl)cyclohexyl)isonicotinamide;N-(hexahydro-3aH-cyclopenta[b]furan-3a-yl)-2-(1H-imidazol-1-yl)isonicotinamide;N-((3aR,6aS)-hexahydro-3aH-cyclopenta[b]furan-3a-yl)-2-(1H-imidazol-1- yl)isonicotinamide;N-((3aS,6aR)-hexahydro-3aH-cyclopenta[b]furan-3a-yl)-2-(1H-imidazol-1- yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(2, 4, 4-trimethylcyclohexyl)isonicotinamide2-(1 H-imidazol-1 -yl)-N-(piperidin-3-yl)isonicotinamide dihydrochloride;(S)-2-(1 H-imidazol-1 -yl)-N-(piperidin-3-yl)isonicotinamide;(S)-2-(1 H-imidazol-1 -yl)-N-(piperidin-3-yl)isonicotinamide dihydrochloride;2-(1 H-imidazol-1 -yl)-N-(tetrahydro-2H-thiopyran-4-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(3-methylpiperidin-4-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(3-methylpiperidin-4-yl)isonicotinamide dihydrochloride; methyl 1-(2-(1 H-imidazol-1 -yl)isonicotinamido)-4-methylcyclohexane-1 -carboxylate;2-(1 H-imidazol-1 -yl)-N-(octahydrobenzofuran-4-yl)isonicotinamide;N-(2,6-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(2-(hydroxymethyl)cycloheptyl)-2-(1 H-imidazol-1-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(1, 4, 4-trimethylpyrrolidin-3-yl)isonicotinamide;N-(azetidin-3-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(azetid i n-3-yl )-2-(1 H-imidazol-1 -yl)isonicotinamide dihydrochloride;2-(1H-imidazol-1-yl)-N-(4-methylpiperidin-4-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(4-methylpiperidin-4-yl)isonicotinamide dihydrochloride;N-(4-(tert-butoxy)pyridin-3-yl)-2-(1 H-imidazol-1-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(piperidin-4-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(piperidin-4-yl)isonicotinamide dihydrochloride;N-(2,2-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(4-methylpiperidin-3-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(4-methylpiperidin-3-yl)isonicotinamide dihydrochloride;2-(1 H-imidazol-1 -yl)-N-(2, 2, 6, 6-tetramethylpiperidin-4-yl)isonicotinamide;2-(1 H-imidazol-1 -yl )- N-( 1 methylcyclopentyl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(1, 7, 7-trimethylbicyclo[2.2.1]heptan-2-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(3-methoxy-2, 2, 3-trimethylcyclobutyl)isonicotinamide;N-(3-chlorophenyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(1 -isopropyl pyrrol idin-3-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(1-(trifluoromethyl)cyclobutyl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(2-methylpiperidin-3-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(2-methylpiperidin-3-yl)isonicotinamide dihydrochloride;2-(1 H-imidazol-1 -yl)-N-(7-methoxybicyclo[3.2.0]heptan-6-yl)isonicotinamide;N-(1-(tert-butyl)pyrrolidin-3-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(2-(tert-butyl)cyclopentyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(1-ethylpiperidin-3-yl)-2-(1 H-imidazol-1-yl)isonicotinamide;N-cyclooctyl-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(2-methylpiperidin-1 -yl)isonicotinamide;N-(2,3-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-( 4,4-difluorocyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(1-(hydroxymethyl)cyclopentyl)-2-(1 H-imidazol-yl)isonicotinamide;N-(1 -azabicyclo[3.2.1 ]octan-5-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(8-azabicyclo[3.2.1]octan-3-yl)-2-(1H-imidazol-1-yl)isonicotinamide;N-(8-azabicyclo[3.2.1]octan-3-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide dihydrochloride;N-(4-hydroxy-1 -methylcyclohexyl )-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(pyrrolidin-3-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(pyrrolidin-3-yl)isonicotinamide dihydrochloride;N-(6-(2,2-difluoroethoxy)pyridin-2-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(octahydroindolizin-1-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(4-methoxycyclohexyl)isonicotinamide;N-(4,4-difluoro-1-methylcyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(1,4-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(spiro[2.5]octan-5-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(3-(trifluoromethyl)cyclohexyl)isonicotinamide;N-(1-ethylcyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(2-isopropyltetrahydro-2H-pyran-4-yl)isonicotinamide;N-(3,3-dimethoxycyclobutyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(1 ,2-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(3-iodophenyl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(1-methylpiperidin-4-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(4-(2-methoxyethoxy)cyclohexyl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(spiro[3.5]nonan-5-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(octahydro-1 H-inden-5-yl)isonicotinamide;N-(2-(hydroxymethyl)cyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(3,4-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(7,7-dimethyl-2-oxabicyclo[3.2.0]heptan-6-yl)-2-(1H-imidazol-1-yl)isonicotinamide;N-(2-(hydroxymethyl)-2-methylcyclopentyl)-2-(1 H-imidazol-1-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(2-methylpiperidin-4-yl)isonicotinamide dihydrochloride;N-(4-bromophenyl)-2-(1H-imidazol-1-yl)isonicotinamide;2-(1 H-imidazol-1 -yl )- N-( 1 phenylpiperidin-4-yl)isonicotinamide;N-(bicyclo[4.1.0]heptan-2-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(5-oxo-1 -phenyl pyrrol idin-3-yl)isonicotinamide;N-(bicyclo[2.2.1]heptan-1-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(2,5-dimethyltetrahydrofuran-3-yl)-2-(1 H-imidazol-1-yl)isonicotinamide;N-(2-fluorophenyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)isonicotinamide;N-(3,5-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(2-hydroxycyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(6-oxaspiro[3.4]octan-2-yl)isonicotinamide;N-(3-fluorocyclohexyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(1 -ethyl-4,4-di methyl pyrrol idin-3-yl)-2-(1 H-imidazol-1 -yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-(2-methyltetrahydrofuran-3-yl)isonicotinamide;2-(1 H-imidazol-1 -yl)-N-((2S,3S)-2-methyltetrahydrofuran-3-yl)isonicotinamide; ethyl 1 -(2-(1 H-imidazol-1 -yl)isonicotinamido)cyclopentane-1 -carboxylate;N-(3-bromophenyl)-2-(4H-1 ,2,4-triazol-4-yl)isonicotinamide;N-(4-fluorophenyl)-2-(4H-1 ,2,4-triazol-4-yl)isonicotinamide;N-(3-chlorophenyl)-2-(4H-1 ,2,4-triazol-4-yl)isonicotinamide;N-(2-iodophenyl)-2-(4H-1 ,2,4-triazol-4-yl)isonicotinamide;N-(pyridin-3-yl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-(pyridin-4-yl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-(4-chlorophenyl)-2-(4H-1 ,2,4-triazol-4-yl)isonicotinamide;N-(2-chlorophenyl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-(5-bromopyridin-2-yl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-(4-bromophenyl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-phenyl-2-(4H-l,2,4-triazol-4-yl)isonicotinamide;N-(4-methylpyridin-2-yl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-(pyridin-2-yl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-(4-iodophenyl)-2-(4H-1,2,4-triazol-4-yl)isonicotinamide;N-(4-(2-methoxyethoxy)cyclohexyl)-2-(thiazol-5-yl)-6-(trifluoromethyl)isonicotinamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2-(thiazol-5-yl)-6-(trifluoromethyl)isonicotinamideN-(2-(1 -hydroxyethyl)phenyl)-2-(1 H-imidazol-1 -yl)isonicotinamide;N-(3-(hydroxymethyl)phenyl)-2-(1H-imidazol-1-yl)isonicotinamide;N-(2,4-dimethylcyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(3-isopropylcyclohexyl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(1-isopropylpiperidin-4-yl)picolinamide;N-(4-(hydroxymethyl)cyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;N-((1 r,4r)-4-(hydroxymethyl)cyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(3-ethoxyspiro[3.5]nonan-1-yl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(4-methyltetrahydro-2H-pyran-4-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(3-methyltetrahydro-2H-pyran-3-yl)picolinamide;N-(2-ethylcyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(1-acetylpiperidin-4-yl)-4-(1H-imidazol-1-yl)picolinamide;N-(1-(hydroxymethyl)cyclopentyl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(2-oxabicyclo[4.2.0]octan-7-yl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(1-(tert-butyl)piperidin-4-yl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(6-oxaspiro[3.4]octan-2-yl)picolinamide;4-(1H-imidazol-1-yl)-N-(2-isopropyltetrahydro-2H-pyran-4-yl)picolinamide;N-(2,2-dimethylcyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(4-fluorotetrahydrofuran-3-yl)-4-(1H-imidazol-1-yl)picolinamide;N-((3S,4S)-4-fluorotetrahydrofuran-3-yl)-4-(1 H-imidazol-1-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(2-methyltetrahydrofuran-3-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-((2S,3S)-2-methyltetrahydrofuran-3-yl)picolinamide;N-(2,3-dimethyltetrahydrofuran-3-yl)-4-(1 H-imidazol-yl)picolinamide;N-(4,4-dimethylcyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(2-(hydroxymethyl)cyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(1 -(hydroxymethyl)-3,3,5-trimethylcyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(1 ,2-dimethylpiperidin-4-yl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(2-methylcyclohexyl)picolinamide;N-(1,1-dioxidotetrahydro-2H-thiopyran-3-yl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(4,4-difluorocyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(1-isobutyrylpiperidin-4-yl)picolinamide;N-(1-(tert-butyl)-5-oxopyrrolidin-3-yl)-4-(1 H-imidazol-1 -yl)picolinamide;N-cyclobutyl-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(4-isopropylcyclohexyl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(2, 2, 5, 5-tetramethyltetrahydrofuran-3-yl)picolinamide;N-(1,4-dimethylcyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(2-methoxycyclohexyl)picolinamide;4-(1 H-imidazol-1 -yl)-N-((1S,2S)-2-methoxycyclohexyl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(2-isopropylcyclohexyl)picolinamide;N-(1 -acetyl pyrrolidin-3-yl)-4-(1H-imidazol-1-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)picolinamide;N-(1-ethylpiperidin-3-yl)-4-(1 H-imidazol-1-yl)picolinamide;(S)-N-(1-ethylpiperidin-3-yl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(4-methylcycloheptyl)picolinamideN-(1-ethylpiperidin-4-yl)-4-(1 H-imidazol-1-yl)picolinamide;N-(8, 8-dimethyl-2-oxabicyclo[4.2.0]octan-7-yl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(2-methyltetrahydro-2H-pyran-4-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(3-methylcyclohexyl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(3-methyltetrahydrofuran-3-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(3-(trifluoromethyl)cyclohexyl)picolinamide;N-(2-(hydroxymethyl)-2-methylcyclopentyl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(2-hydroxycyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(4-(trifluoromethyl)cyclohexyl)picolinamide;N-(2,3-dimethylcyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(tetrahydro-2H-pyran-3-yl)picolinamide;N-(1 -ethyl-4,4-di methyl pyrrol idin-3-yl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(1-isopropyl-4-methyl pyrrol idin-3-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(3-methoxycyclopentyl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(octahydro-1 H-inden-5-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(1-methylpiperidin-4-yl)picolinamide;N-(2,2-dimethylcyclopentyl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(tetrahydro-2H-pyran-4-yl)picolinamide;4-(1 H-imidazol-1 -yl)-N-(4-methylcyclohexyl)picolinamide;4-(1 H-imidazol-1 -yl)-N-((1 ,4r)-4-methylcyclohexyl)picolinamide;N-(1,1-dioxidotetrahydrothiophen-3-yl)-4-(1 H-imidazol-1 -yl)picolinamide;N-(3-ethylcyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;4-(1H-imidazol-1-yl)-N-(1-methylcyclohexyl)picolinamide;N-(4-ethylcyclohexyl)-4-(1H-imidazol-1-yl)picolinamide;4-(1H-imidazol-1-yl)-N-(1-methyl-6-oxopiperidin-3-yl)picolinamide;4-(1H-imidazol-1-yl)-N-(1-methyl-2-oxopiperidin-3-yl)picolinamide;N-(3,5-dimethylcyclohexyl)-4-(1 H-imidazol-1 -yl)picolinamide;2-(1 H-imidazol-1 -yl)-N-(4-(2-methoxy-2-methyl propoxy )cyclohexyl)-6-methylpyrimidine- 4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxy-2-methyl propoxy )cyclohexyl)-6- methylpyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-6-methyl-N-(pyridin-4-yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-6-methyl-N-(pyridin-3-yl)pyrimidine-4-carboxamide;6-(difluoromethyl)-2-(1H-imidazol-1-yl)-N-(4-(2-methoxyethoxy)cyclohexyl)pyrimidine-4- carboxamide;6-(difluoromethyl)-2-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)pyrimid i ne-4-carboxa m ide ;5-chloro-N-(2-chlorophenyl)-2-(1H-imidazol-1-yl)pyrimidine-4-carboxamide;N-(4-ethoxycyclohexyl)-2-(1H-imidazol-1-yl)pyrimidine-4-carboxamide;N-((1 r,4r)-4-ethoxycyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;6-(fluoromethyl)-2-(1 H-imidazol-1 -yl)-N-(4-(2-methoxyethoxy)cyclohexyl)pyrimidine-4- carboxamide;6-(fluoromethyl)-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2- methoxyethoxy)cyclohexyl ) pyri m id i ne-4-carboxa m ide ;2-(1 H-imidazol-1 -yl)-N-(3-(2-methoxyethoxy)cyclobutyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,3r)-3-methoxyethoxy)cyclobutyl)pyrimidine-4-carboxamide;5-bromo-N-(3,4-dichlorophenyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;6-ethoxy-2-(1H-imidazol-1-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)pyrimidine-4- carboxamide;2-(1H-imidazol-1-yl)-N-(4-(2-methoxyethoxy)cyclohexyl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6- (trifluoromethyl)pyrimidine-4-carboxamide;5-bromo-N-(2-chlorophenyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide;N-(4-hydroxy-4-methylcyclohexyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide;N-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;N-((1 s,4s)-4-hydroxy-4-methylcyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-6-methoxy-N-(2-(trifluoromethyl)pyridin-4-yl)pyrimidine-4- carboxamide;N-(4-(difluoromethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methylpyrimidine-4- carboxamide;N-((1 r,4r)-4-(difluoromethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methylpyrimidine-4- carboxamide;6-cyclopropyl-2-(1 H-imidazol-1 -yl)-N-(4-(2-methoxyethoxy)cyclohexyl)pyrimidine-4- carboxamide;6-cyclopropyl-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)pyrimidine- 4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(4-(2-methoxyethoxy)cyclohexyl)-6-methylpyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-methylpyrimidine-4- carboxamide;6-(hydroxymethyl)-2-(1 H-imidazol-1 -yl)-N-(4-(2-methoxyethoxy)cyclohexyl)pyrimidine-4- carboxamide;6-(hydroxymethyl)-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2- methoxyethoxy)cyclohexyl)pyrimidine-4-carboxamide;5-chloro-2-(1 H-imidazol-1-yl)-N-phenylpyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(4-methoxycyclohexyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrimidine-4-carboxamide;5-bromo-N-(4-chlorophenyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide;2-(1H-imidazol-1-yl)-N-(4-(2-methoxyethoxy)cyclohexyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxyethoxy)cyclohexyl)pyrimidine-4-carboxamide;N-(4-(difluoromethoxy)cyclohexyl)-2-(1H-imidazol-1-yl)pyrimidine-4-carboxamide;N-((1 r,4r)-4-(difluoromethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;5-bromo-N-(2-fluorophenyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;N-(4-hydroxycyclohexyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide;N-((1r,4r)-4-hydroxycyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;6-cyclopropyl-2-(1 H-imidazol-1 -yl)-N-(2-(trifluoromethyl)pyridine-4-yl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-(4-methoxy-4-methylcyclohexyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxy-4-methylcyclohexyl)pyrimidine-4-carboxamide; 5-chloro-N-(2-fluorophenyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;5-chloro-N-(4-fluorophenyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-6-(2-methoxyethoxy)-N-(2-(trifluoromethyl)pyridin-4-yl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl-d3)-N-(4-(2-methoxyethoxy)cyclohexyl)-6-methylpyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl-d3)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-methylpyrimidine-4- carboxamide;6-(2-methoxyethoxy)-2-(1 -methyl-1 H-imidazol-5-yl)-N-(2-(trifluoromethyl)pyridin-4- 0-0 / yl )pyri m id i ne-4-carboxa m ide ;6-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)pyrazine-2-carboxamide;3-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-methoxycyclohexyl)-5-methylbenzamide;3-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-methoxycyclohexyl)-5-(1 -methyl-1 H-pyrazol-4- yl)benzamide;3-((R)-2-(hydroxymethyl)pyrrolidin-1-yl)-5-(1 H-imidazol-1 -yl)-N-((1r,4R)-4- methoxycyclohexyl)benzamide;3-((S)-2-hydroxypyrrolidin-1 -yl)-5-(1 H-imidazol-1 -yl)-N-((1 r,4S)-4- methoxycyclohexyl)benzamide;3-((R)-2-(hydroxymethyl)pyrrolidin-1-yl)-N-((1r,4R)-4-methoxycyclohexyl)-5-(thiazol-5- yl)benzamide;N-((1r,4r)-4-methoxycyclohexyl)-3-(1-methyl-1H-pyrazol-4-yl)-5-(thiazol-5-yl)benzamide;N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-3-(1 -methyl-1 H-pyrazol-4-yl)-5-(thiazol-5- yl)benzamide;3-(4-(hydroxymethyl)-1H-imidazol-1-yl)-5-(2-methoxyethoxy)-N-(2- (trifluoromethyl)pyridin-4-yl)benzamide;3-(1 H-imidazol-1 -yl)-N-(isoquinolin-7-yl)-5-(2-methoxyethoxy)benzamide;3-(1 H-imidazol-1 -yl)-N-(isochroman-6-yl)-5-(2-methoxyethoxy)benzamide;N-(2-(tert-butyl)pyrimidin-5-yl)-3-(1 H-imidazol-1 -yl)-5-(2-methoxyethoxy)benzamide;N-(6-cyanopyridin-3-yl)-3-(1 H-imidazol-1 -yl)-5-(2-methoxyethoxy)benzamide;N-(5-chloropyridin-3-yl)-3-(1H-imidazol-1-yl)-5-(2-methoxyethoxy)benzamide;3-(2-(dimethylamino)ethoxy)-5-(1 H-imidazol-1 -yl)-N-(2-(trifluoromethyl)pyridin-4- yl)benzamide;N-(5-chloropyridin-3-yl)-3-cyclopropoxy-5-(1H-imidazol-1-yl)benzamide;3-(1 H-imidazol-1 -yl)-5-(2-methoxyethoxy)-N-(quinolin-7-yl)benzamide;N-(3-chloro-4-fluorophenyl)-3-(1 H-imidazol-1 -yl)-5-(2-methoxyethoxy)benzamide;3-(1 H-imidazol-1 -yl)-5-(2-methoxyethoxy)-N-(6-(trifluoromethyl)pyridin-3-yl)benzamide;2-chloro-5-(1H-imidazol-1-yl)-3-(2-methoxyethoxy)-N-(2-(trifluoromethyl)pyridin-4- yl)benzamide;3-(1 H-imidazol-1 -yl)-5-(2-methoxyethoxy)-N-(2-(trifluoromethyl)pyridin-4-yl)benzamide;3-(1 H-imidazol-1 -yl)-5-methoxy-N-(2-(trifluoromethyl)pyridin-4-yl)benzamide;3-(2-methoxyethoxy)-5-(thiazol-5-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)benzamide;2-fluoro-5-(1H-imidazol-1-yl)-3-(2-methoxyethoxy)-N-(2-(trifluoromethyl)pyridin-4- yl)benzamide;3-(5-(hydroxymethyl)-1H-imidazol-1-yl)-5-(2-methoxyethoxy)-N-(2- (trifluoromethyl)pyridin-4-yl)benzamide;3-(5-(hydroxymethyl)-1H-imidazol-1-yl)-5-methoxy-N-(2-(trifluoromethyl)pyridin-4- yl)benzamide;3-(2-methoxyethoxy)-5-(pyridin-3-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)benzamide;3-(4-hydroxy-1 H-pyrazol-1-yl)-5-(2-methoxyethoxy)-N-(2-(trifluoromethyl)pyridin-4- yl)benzamide;3-(4-amino-1 H-pyrazol-1-yl)-5-(2-methoxyethoxy)-N-(2-(trifluoromethyl)pyridin-4- yl)benzamide;N-(1 H-imidazo[4,5-c]pyridin-2-yl)-3-(1 H-imidazol-1 -yl)-5-(2-methoxyethoxy)benzamide;3-(1 H-imidazol-1 -yl)-5-(2-methoxyethoxy)-N-(4-phenyl-1 H-imidazol-2-yl)benzamide;N-(4-cyclopropyl-1 H-imidazol-2-yl)-3-(1 H-imidazol-1 -yl)-5-(2-methoxyethoxy)benzamide;3-(1 H-imidazol-1 -yl )- N-( 1 H-indazol-5-yl)-5-(2-methoxyethoxy)benzamide;N-(1H-benzo[d]imidazol-5-yl)-3-(1 H-imidazol-1 -yl)-5-(2-methoxyethoxy)benzamide;3-(1 H-imidazol-1 -yl)-5-(2-methoxyethoxy)-N-(quinoxalin-6-yl)benzamide;3-(1 H-imidazol-1 -yl)-5-morpholino-N-(2-(trifluoromethyl)pyridin-4-yl)benzamide;(S)-3-(1 H-imidazol-1 -yl)-5-(3-(methoxymethyl)pyrrolidin-1-yl)-N-(2- (trifluoromethyl)pyridin-4-yl)benzamide;(S)-3-(3-(hydroxymethyl)pyrrolidin-1-yl)-5-(1 H-imidazol-1 -yl)-N-(2-(trifluoromethyl)pyridin- 4-yl )benzam ide;(R)-3-(2-(hydroxymethyl)pyrrolidin-1-yl)-5-(1 H-imidazol-1 -yl)-N-(2-(trifluoromethyl)pyridin- 4-yl )benzam ide;3-(1-methyl-1H-pyrazol-4-yl)-5-(thiazol-5-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)benzamide;3-(1 H-imidazol-1 -yl )-5-( 1 -methyl-1 H-pyrazol-4-yl)-N-(2-(trifluoromethyl)pyridin-4- yl)benzamide;3-(5-(hydroxymethyl)-1 H-imidazol-1 -yl)-5-(1 -methyl-1 H-pyrazol-4-yl)-N-(2- (trifluoromethyl)pyridin-4-yl)benzamide;3-(1 H-imidazol-1 -yl)-5-(piperazin-1-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)benzamide;N-((1 r,4r)-4-((2-Hydroxy-2-(trifluoromethyl)butyl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl)- 1 H-indole-7-carboxamide;N-((1 s,4s)-4-((2-Hydroxy-2-(trifluoromethyl)butyl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl)- 1 H-indole-7-carboxamide;5-(1 H-lmidazol-1 -yl)-N-((1 R,4r)-4-(((R)-1 , 1 ,1 -trifluoro-3-hydroxy-2-methylpropan-2- yl)amino)cyclohexyl)-1 H-indole-7-carboxamide;N-((1 r, 4r)-4-(2-Hydroxy-2-methyl propoxy )cyclohexyl)-5-(1 H-imidazol-1 -yl)-3-isopropyl- 1 H-indole-7-carboxamide;5-(1 H-lmidazol-1 -yl)-N-((1s, 4s)-4-(methylcarbamoyl)cyclohexyl)-1 H-indole-7- carboxamide;5-(1 H-imidazol-1 -yl)-N-((1s, 4s)-4-(2-methoxyethoxy)cyclohexyl)-1H-indole-7- carboxamide;N-((1 r,4r)-4-(2-Hydroxy-2-methyl propoxy )cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-indole-7- carboxamide;N-((1 r,4r)-4-(2-Hydroxypropoxy)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-indole-7-Carboxamide;3-Chloro-N-((1 r,4r)-4-(2-hydroxypropoxy)cyclohexyl)-5-(1 H-imidazol-1 -1 -yl )- 1 H-indole-7- carboxamide;5-(1 H-lmidazol-1 -yl )- N-((1 r,4r)-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropoxy)cyclohexyl)- 1 H-indole-7-carboxamide;5-1 H-lmidazol-1 -yl)-N-((1r, 4r)-4-((3, 3, 3-trifluoro-2-hydroxy-2- methylpropyl)amino)cyclohexyl)-1 H-indole-7-carboxamide;5-1 H-lmidazol-1 -yl)-N-((1r, 4r)-4-(3, 3, 3-trifluoro-2-hydroxy-2- methylpropanamido)cyclohexyl)-1H-indole-7-carboxamide;N-((1 r,4r)-4-((2,2-Difluoroethyl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl )-1 H-indole-7- carboxamide;3-Chloro-N-((1 r,4r)-4-((2,2-difluoroethyl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H- indole-7-carboxamide;N-((1 r,4r)-4-(2-Hydroxy-3-methylbutoxy)cyclohexyl)-5-(1 H-imidazol-1-yl)-1 H-indole-7- carboxamide;N-((1 r,4r)-4-(2-Cylopropyl-2-hydroxypropoxy)cyclohexyl)-5-(1 H-imidazol-1-yl)-1 H- indole-7-carboxamide;5-(1H-lmidazol-1-yl)-N-((1R,4r)-4-(((R)-1-(methylsulfonylpropan-2-yl)amino)cyclohexyl)-1 H-indole-7-carboxamide;4-((4-chloro-3-fluorophenyl)amino)-6-(thiazol-5-yl)quinoline-3-carboxamide;N-(4-chloro-3-fluorophenyl)-6-(thiazol-5-yl)quinolin-4-amine;N-phenyl-6-(thiazol-5-yl)quinazolin-4-amine;N-(4-chloro-3-fluorophenyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(4-chlorophenyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(3-chlorophenyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(2-chlorophenyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(4-fluorophenyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(3-fluorophenyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(2-fluorophenyl)-6-(thiazol-5-yl)quinazolin-4-amine;6-(thiazol-5-yl)-N-(p-tolyl)quinazolin-4-amine;6-(thiazol-5-yl)-N-(m-tolyl)quinazolin-4-amine;6-(thiazol-5-yl)-N-(o-tolyl)quinazolin-4-amine;6-(thiazol-5-yl)-N-(3-(trifluoromethyl)phenyl)quinazolin-4-amine;4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)benzenesulfonamide;N-(4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)phenyl)methanesulfonamide;N-(3-(methylsulfonyl)phenyl)-6-(thiazol-5-yl)quinazolin-4-amine;4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)benzamide;N-(4-(isoxazol-5-yl)phenyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(4-(1H-imidazol-1-yl)phenyl)-6-(thiazol-5-yl)quinazolin-4-amine;1-(4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)phenyl)piperidin-2-one;N-(pyridin-2-yl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(pyridin-3-yl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(pyrid i n-4-yl )-6-(th iazol-5-yl )qu i nazol i n-4-a m i ne ;N-cyclopropyl-6-(thiazol-5-yl)quinazolin-4-amine;N-cyclobutyl-6-(thiazol-5-yl)quinazolin-4-amine;N-cyclopentyl-6-(thiazol-5-yl)quinazolin-4-amine;N-cyclohexyl-6-(thiazol-5-yl)quinazolin-4-amine;N-(tetrahydrofuran-2-yl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(tetra hyd ro-2H- pyra n-4-yl )-6-(th iazol -5-yl )qu i nazol i n-4-a mine;N-(tetra hyd ro-2H- pyra n-3-yl )-6-(th iazol -5-yl )qu i nazol i n-4-a mine;N-(piperidin-4-yl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(piperidin-3-yl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(piperidin-2-yl)-6-(thiazol-5-yl)quinazolin-4-amine;4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)piperidine-1-carbaldehyde;4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)tetrahydro-2H-thiopyran1,1 -dioxide;N-(4-methylcyclohexyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(trans-2-methylcyclohexyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(cis-2-methylcyclohexyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(3-methylcyclohexyl)-6-(thiazol-5-yl)quinazolin-4-amine;4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)cyclohexan-1-ol;(1r,4r)-4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)cyclohexane-1-carboxamide;(1s,3s)-3-((6-(thiazol-5-yl)quinazolin-4-yl)amino)cyclohexane-1-carboxamide;(1r,4r)-N-ethyl-4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)cyclohexane-1-carboxamide;(1s,4s)-4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)cyclohexane-1-carboxylicacid;(1r,4r)-4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)cyclohexane-1-carboxylicacid;1-((1s,4s)-4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)cyclohexyl)piperidin-2-one;1-((1r,4r)-4-((6-(thiazol-5-yl)quinazolin-4-yl)amino)cyclohexyl)piperidin-2-one;N-ethyl -6-(th iazol -5-yl )qu i nazol i n-4-am i ne ;N-isopropyl-6-(thiazol-5-yl)quinazolin-4-amine;N-(tert-butyl)-6-(thiazol-5-yl)quinazolin-4-amine;2-((6-(thiazol-5-yl)quinazolin-4-yl)amino)ethan-1-ol;N-(2-methoxyethyl)-6-(thiazol-5-yl)quinazolin-4-amine;N-(3-Chloro-4-fluorophenyl)-8-methoxy-6-(thiazol-5-yl)-quinazolin-4-amine;4-{[8-(Methyloxy)-6-(1,3-thiazol-5-yl)-4-quinazolinyl]amino}-benzamide;N-(3-Chloro-4-fluorophenyl)-6-(1,3-thiazol-5-yl)-8-(trifluoromethyl)-4-quinazolinamine;4-{[6-(1,3-Thiazol-5-yl)-8-(trifluoromethyl)-4-quinazolinyl]-amino}benzamide;N-(3-Chloro-4-fluorophenyl)-8-methyl-6-(1,3-thiazol-5-yl)-4-quinazolinamine;4-((3-Chloro-4-fluorophenyl)amino)-8-methyl-6-(thiazol-5-yl)quinazolin-2(1H)-one;4-(((1s,4s)-4-Methoxycyclohexyl)amino)-8-methyl-6-(thiazol-5-yl)quinazolin-2(1H)-one;4-(((1s,4s)-4-(2-Methoxyethoxy)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinazolin- 2(1H)-one;4-(((1s,4s)-4-Methoxycyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinazolin-2(1H)-one;(1s,4s)-N-Methyl-4-((2-methyl-6-(thiazol-5-yl)-8-(trifluoromethyl)quinazolin-4-yl)amino)- cyclohexanecarboxamide;(1s,4s)-N-Methyl-4-((8-methyl-6-(thiazol-5-yl)-2-(trifluoromethyl)quinazolin-4-yl)amino)- cyclohexanecarboxamide;(1s,4s)-4-((2,8-Dimethyl-6-(thiazol-5-yl)quinazolin-4-yl)-amino)-N- methylcyclohexanecarboxamide;(1s,4s)-N-Methyl-4-((2-oxo-6-(thiazol-5-yl)-1,2-dihydroquinolin-4- yl)amino)cyclohexanecarboxamide;4-((Tetrahydro-2H-pyran-4-yl)amino)-6-(thiazol-5-yl)-quinolin-2(1H)-one;4-(((1s,4s)-4-(2-Methoxyethoxy)cyclohexyl)amino)-6-(thiazol-5-yl)quinolin-2(1H)-one;(1r,4r)-N-Methyl-4-((8-methyl-2-oxo-6-(thiazol-5-yl)-1,2-dihydroquinolin-4- yl)amino)cyclohexanecarboxamide;8-Methyl-4-((tetrahydro-2H-pyran-4-yl)amino)-6-(thiazol-5-yl)quinolin-2(1H)-one;4-(((1s,4s)-4-(2-Methoxyethoxy)cyclohexyl)amino)-8-methyl-6-(thiazol-5-yl)quinolin- 2(1 H)-one;4-(((1s,4s)-4-Methoxycyclohexyl)amino)-8-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one;(1r,4r)-N-Methyl-4-((1-methyl-2-oxo-6-(thiazol-5-yl)-1,2-dihydroquinolin-4- yl)amino)cyclohexanecarboxamide;1-Methyl-4-((tetrahydro-2H-pyran-4-yl)amino)-6-(thiazol-5-yl)quinolin-2(1H)-one;4-(((1 r,4r)-4-(2-Methoxyethoxy)cyclohexyl)amino)-1 -methyl6-(thiazol-5-yl)quinolin-2(1 H)- one;4-(((1r,4r)-4-Methoxycyclohexyl)amino)-1-methyl-6-(thiazol5-yl)quinolin-2(1H)-one;4-(((1s,4s)-4-Hydroxycyclohexyl)amino)-1-methyl-6-(thiazol5-yl)quinolin-2(1 H)-one trifluoroacetic Acid salt;4-Amino-1-methyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;(1 r,4r)-4-((1 ,8-Dimethyl-2-oxo-6-(thiazol-5-yl)-1 ,2-dihydroquinolin-4-yl)amino)-N- methylcyclohexanecarboxamide;1,8-Dimethyl-4-((tetrahydro-2H-pyran-4-yl)amino)-6-(thiazol-5-yl)quinolin-2(1H)-one;4-(((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)amino)-1 ,8-dimethyl-6-(thiazol-5-yl)quinolin- 2(1 H)-one;4-(((1 r,4r)-4-Methoxycyclohexyl)amino)-1 ,8-dimethyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;(1r,4r)-4-((1-Ethyl-2-oxo-6-(thiazol-5-yl)-1,2-dihydroquinolin-4-yl)amino)-N- methylcyclohexanecarboxamide;1-Ethyl-4-(((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-6-(thiazol-5-yl)quinolin-2(1H)- one;4-{[(2,6-Dimethylphenyl)methyl]amino}-2-methyl-8-quinolinecarboxamide;4-Amino-2-methyl-8-quinolinecarboxamide;4-(Benzylamino)-2-methylquinoline-8-carboxamide;2-Methyl-4-(2-methylbenzylamino)quinoline-8-carboxamide;2-Methyl-4-(2-methylbenzylamino)quinoline-8-carboxamide;4-((2-Methoxybenzyl)amino)-2-methylquinoline-8-carboxamide;2-Methyl-4-((3-methylbenzyl)amino)quinoline-8-carboxamide;4-{[(3-Chlorophenyl)methyl]amino}-2-methyl-8-quinolinecarboxamide;4-((3-Methoxybenzyl)amino)-2-methylquinoline-8-carboxamide;2-Methyl-4-((4-methylbenzyl)amino)quinoline-8-carboxamide;4-(4-Chlorobenzylamino)-2-methylquinoline-8-carboxamide;4-((4-Methoxybenzyl)amino)-2-methylquinoline-8-carboxamide;2-Methyl-4-(2-(trifluoromethyl)benzylamino)quinoline-8-carboxamide;4-(2-Bromobenzylamino)-2-methylquinoline-8-carboxamide;4-(2-Carbamoylbenzylamino)-2-methylquinoline-8-carboxamide;(2,3-Dimethylbenzylamino)-2-methylquinoline-8-carboxamidetrifluoroacetate;4-{[(2,3-Dichlorophenyl)methyl]amino}-2-methyl-8-quinolinecarboxamide;4-(2,4-Dimethylbenzylamino)-2-methylquinoline-8-carboxamidetrifluoroacetate;4-(2,4-Dichlorobenzylamino)-2-methylquinoline-8-carboxamide(1s);4-(2,5-Dimethylbenzylamino)-2-methylquinoline-8-carboxamide;2-Methyl-4-(2-methylbenzylamino)quinoline-8-carboxamide;4-(2,6-Dichlorobenzylamino)-2-methylquinoline-8-carboxamide;4-(3,4-Dimethylbenzylamino)-2-methylquinoline-8-carboxamide;4-(3,4-Dichlorobenzylamino)-2-methylquinoline-8-carboxamideHydrochloride;4-(3,5-Dimethylbenzylamino)-2-methylquinoline-8-carboxamide;4-(3,5-Dichlorobenzylamino)-2-methylquinoline-8-carboxamide;4-(3-Chloro-2-fluorobenzylamino)-2-methylquinoline-8-carboxamide;4-(3-Chloro-2-methylbenzylamino)-2-methylquinoline-8-carboxamide;4-(2-Fluoro-3-(trifluoromethyl)benzylamino)-2-methylquinoline-8-carboxamide;-Methyl-4-(naphthalen-1-ylmethylamino)quinoline-8-carboxamide; -(2-Chloro-3,6-difluorobenzylamino)-2-methylquinoline-8-carboxamide; -(2-Chloro-6-fluorobenzylamino)-2-methylquinoline-8-carboxamide; -(2-Chloro-6-methylbenzylamino)-2-methylquinoline-8-carboxamide; -((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-methylquinoline-8-carboxamide; -Methyl-4-{[(2,3,6-trichlorophenyl)methyl]amino}-8-quinolinecarboxamide; -{[(3-Chloro-2,6-difluorophenyl)methyl]amino}-2-methyl-8-quinolinecarboxamide;-(2-Chloro-3,6-difluorobenzylamino)-2-methylquinoline-8-carboxamide; -{[(3,6-Dichloro-2-fluorophenyl)methyl]amino}-2-methyl-8-quinolinecarboxamide;-{[(2,3-Dichloro-6-fluorophenyl)methyl]amino}-2-methyl-8-quinolinecarboxamide;-{[(2-Chloro-6-fluoro-3-methylphenyl)methyl]amino}-2-methyl-8-quinolinecarboxamide;-Methyl-4-({[3-(trifluoromethyl)-2-pyridinyl]methyl}-amino)-8-quinolinecarboxamide;-Methyl-4-({[4-(trifluoromethyl)-3-pyridinyl]methyl}-amino)-8-quinolinecarboxamide;-{[(3-Chloro-4-pyridinyl)methyl]amino}-2-methyl-8-quinolinecarboxamide; -Methyl-4-({[2-(trifluoromethyl)-3-pyridinyl]methyl}-amino)-8-quinolinecarboxamide;-{[(3-Chloro-2-thienyl)methyl]amino}-2-methyl-8-quinolinecarboxamide; -{[(3,5-Dimethyl-4-isoxazolyl)methyl]amino}-2-methyl-8-quinolinecarboxamide; -[(Cyclohexyl methyl )amino]-2-methyl-8-quinolinecarboxamide; -{[(1-Acetyl-4-piperidinyl)methyl]amino}-2-methyl-8-quinolinecarboxamide; -Methyl-4-{[(1-methyl-4-piperidinyl)methyl]amino}-8-quinolinecarboxamide; -Methyl-4-{[(1R)-1-(2-methylphenyl)ethyl]amino}-8-quinolinecarboxamide; -{[(1S)-1-(2,6-Dimethylphenyl)ethyl]amino}-2-methyl-8-quinolinecarboxamide; -Methyl-4-[(1R)-1,2,3,4-tetrahydro-1-naphthalenylamino]-8-quinolinecarboxamide;-((2,6-Dichlorobenzyl)(methyl)amino)-2-methylquinoline8-carboxamide; -(2,6-Dichlorobenzamido)-2-methylquinoline-8-carboxamide; -((2,6-Dichlorobenzyl)oxy)-2-methylquinoline-8-carboxamide;4-((2,6-Dichlorobenzyl)thio)-2-methylquinoline-8-carboxamide;6-Fluoro-2-methyl-4-((2,3,6-trichlorobenzyl)amino)quinoline8-carboxamide;4-{[(2,6-Dimethylphenyl)methyl]amino}-2,6-dimethyl-8-quinolinecarboxamide;6-Bromo-4-((2,6-dimethylbenzyl)amino)-2-methylquinoline8-carboxamide;4-{[(2,6-Dimethylphenyl)methyl]amino}-2-methyl-6-phenyl8-quinolinecarboxamide;N-[(2,3-Dichlorophenyl)methyl]-2-methyl-4-quinolinamine;8-Bromo-N-[(2,3-dichlorophenyl)methyl]-2-methyl-4-quinolinamine;4-{[(2,3-Dichlorophenyl)methyl]amino}-N,2-dimethyl-8-quinolinecarboxamide;4-{[(2,3-Dichlorophenyl)methyl]amino}-N,N,2-trimethyl-8-quinolinecarboxamide;Methyl 4-{[(2,3-Dichlorophenyl)methyl]amino}-2-methyl-8-quinolinecarboxylate;4-{[(2,3-Dichlorophenyl)methyl]amino}-2-methyl-8-quinolinecarboxylicacid;(4-{[(2,3-Dichlorophenyl)methyl]amino}-2-methyl-8-quinolinyl)methanol;8-(Aminomethyl)-N-[(2,3-dichlorophenyl)methyl]-2-methyl4-quinolinamine;4-{[(2,3-Dichlorophenyl)methyl]amino}-2-methyl-8-quinolinecarbonitrile;4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)-2-methylquinoline-8-carboxamide;2-(((1H-pyrazol-4-yl)methyl)amino)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)quinoline-8-carboxamide;2-(((1H-pyrazol-4-yl)methyl)amino)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(((1H-pyrazol-3-yl)methyl)amino)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(((1 H-1 ,2,4-triazol-3-yl)methyl)amino)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(((1H-imidazol-4-yl)methyl)amino)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(((1H-imidazol-2-yl)methyl)amino)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(((1H-Tetrazol-5-yl)methyl)amino)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide trifluoroacetate;4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-((oxazol-2-ylmethyl)amino)quinazoline-8- carboxamide;4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-((oxazol-5-ylmethyl)amino)quinazoline-8- carboxamide;4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-((isoxazol-3-ylmethyl)amino)quinazoline- 8-carboxamide;2-(((1H-Pyrazol-5-yl)methyl)(methyl)amino)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-(((3-methyl1H-pyrazol-4- yl)methyl)amino)quinazoline-8-carboxamide;2-(4,6-Dihydropyrrolo[3,4-c]pyrazol-5(1H)-yl)-4-({[2-fluoro-6-(trifluoromethyl)phenyl]methyl}amino)-8-quinazolinecarboxamide;2-(6,7-Dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(4,5-Dihydro-1H-pyrazolo[3,4-c]pyridin-6(7H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(5,6-Dihydropyrazolo[3,4-c]azepin-7(1H,4H,8H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;(R)-4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-(6-methylpyrrolo[3,4-c]pyrazol- 5(1H,4H,6H)-yl)quinazoline-8-carboxamide;(S)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)-2-(6-methylpyrrolo[3,4-c]pyrazol- 5(1H,4H,6H)-yl)quinazoline-8-carboxamide;4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-(1 -methyl pyrrolo[3,4-c]pyrazol- 5(1H,4H,6H)-yl)quinazoline-8-carboxamide;4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-(2-methylpyrrolo[3,4-c]pyrazol- 5(2H,4H,6H)-yl)quinazoline-8-carboxamide;4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-(3-methylpyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)quinazoline-8-carboxamide;(S)-4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-(4-methylpyrrolo[3,4-c]pyrazol- 5(1H,4H,6H)-yl)quinazoline-8-carboxamide;(R)-4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-(4-methylpyrrolo[3,4-c]pyrazol- 5(1H,4H,6H)-yl)quinazoline-8-carboxamide;(R)-2-(6-Ethylpyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;(S)-2-(6-ethylpyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(3-Ethylpyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-4-((2-fluoro6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-(3-(trifluoromethyl)pyrrolo[3,4-c]pyrazol- 5(1H,4H,6H)-yl)quinazoline8-carboxamide;4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-(3-oxo-2,3-dihydropyrrolo[3,4-c]pyrazol- 5(1H,4H,6H)-yl)quinazoline-8-carboxamide, trifluoroacetic acid salt;2-(3-Aminopyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(3-Carbamoylpyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;(S)-4-((2-Fluoro-6-(trifluoromethyl)benzyl)amino)-2-(3-(1-hydroxyethyl)pyrrolo[3,4- c]pyrazol-5(1H,4H,6H)-yl)quinazoline-8-carboxamide trifluoroacetate;(R)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)-2-(3-(1-hydroxyethyl)pyrrolo[3,4- c]pyrazol-5(1H,4H,6H)-yl)quinazoline-8-carboxamide trifluoroacetate;(R)-2-(3,6-Dimethylpyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;(S)-2-(3,6-Dimethylpyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;(R)-2-(3-Amino-6-methylpyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;(S)-2-(3-Amino-6-methylpyrrolo[3,4-c]pyrazol5(1H,4H,6H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(3-Amino-6,6-dimethylpyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(3’-Amino- H-spiro[cyclopropane-1,6’-pyrrolo[3,4-c]pyrazol]-5’(4’H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(3’-Amino- H-spiro[cyclobutane-1,6’-pyrrolo[3,4-c]pyrazol]-5’(4’H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;2-(3’-Amino- H-spiro[cyclopentane-1 ,6’-pyrrolo[3,4-c]pyrazol]-5’(4’H)-yl)-4-((2-fluoro-6- (trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide;N-((1 r,4r)-4-(2-Hydroxy-2-methyl propoxy )cyclohexyl)-5-(1 H-imidazol-1-yl)-1 H-indole-7- carboxamide;N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2-(thiazol-5-yl)-6-(1 H-imidazol-1 - yl)isonicotinamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2,6-di(thiazol-5-yl)isonicotinamide;N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2-(1 -methyl-1 H-pyrazol-4-yl)-6-(thiazol-5- yl)isonicotinamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2-(thiazol-5-yl)-6- (trifluoromethyl)isonicotinamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2,6-di(thiazol-5-yl)pyrimidine-4-carboxamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(methylthio)-2-(thiazol-5-yl)pyrimidine-4- carboxamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(methylthio)-2-(thiazol-5-yl)pyrimidine-4- carboxamide;4-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(thiazol-5- yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)picol inamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-4-(1 -methyl-1 H-pyrazol- 4-yl)picolinamide;6-(1 H-imidazol-1 -yl )-4-( 1 -isopropyl-1 H-pyrazol-4-yl)-N-((1 r,4r)-4-(2- methoxyethoxy )cyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl )-4-( 1 -isopropyl-1 H-pyrazol-4-yl)-N-((1 r,4r)-4-(2- methoxyethoxy)cyclohexyl)picolinamide;4-amino-6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)picolinamide;4.6-di(1 H-imidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-4-(thiazol-5- yl)picolinamide;6-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-4-(thiazol-5- yl)picolinamide;6-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-4- (trifluoromethyl)picolinamide;6-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-4- (trifluoromethyl)picolinamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)isonicotinamide;2.6-di(1 H-imidazol-1 -yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)isonicotinamide;2, 6-di(1 H-imidazol-1 -yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)isonicotinamide;2-(1-ethyl-1H-pyrazol-4-yl)-6-(1 H-imidazol-1 -yl)-N-((1r, 4r)-4-(2- methoxyethoxy )cyclohexyl)isonicotinamide;2-(1 H-imidazol-1 -yl )-6-( 1 -isopropyl-;H-pyrazol-4-yl)-N-((1 r,4r)-4-(2- methoxyethoxy)cyclohexyl ) ison icoti na m ide ;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(1 -methyl-1 H-pyrazol-3-yl)isonicotinamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(1 -methyl-1 H-pyrazol-4-yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy )cyclohexyl)pyrimidine-4- carboxamide;6-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-4-methylpicolinamide;4-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(1 -methyl 1 H-pyrazol-4- yl)picolinamide;N-((1r,4r)-4-hydroxycyclohexyl)-6-(1 H-imidazol-1 -yl)picolinamide;N-cyclohexyl-6-(1H-imidazol-1-yl)picolinamide;6-(1H-imidazol-1-yl)-N-((1r,4r)-4-methoxycyclohexyl)picolinamide;N-((1r,4r)-4-hydroxycyclohexyl)-2-(1H-imidazol-1-yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-methylpyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6- (trifl uoro methyl ) pyri m id i ne-4-carboxa m ide ;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-4- (methylthio)picolinamide;4-(1-Hydroxyethyl)-6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-(2- methoxyethoxy)cyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-4- (methylsulfonyl)picolinamide;4-(2-Hydroxypropan-2-yl)-6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2- methoxyethoxy)cyclohexyl)picolinamide;N-((1 r,4r)-4-(difluoromethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;N-((1 r,4r)-4-(difluoromethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6- methyl pyri midi ne-4- carboxamide;4-Cyano-6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2- methoxyethoxy )cyclohexyl)picolinamide;N-((1 r,4r)-4-(2-hydroxyethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methylpyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-methylpyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-methyl isonicotinamide;6-cyano-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)pyrimidine-4,6- dicarboxamide;6-(hydroxymethyl)-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2- methoxyethoxy)cyclohexyl ) pyri m id i ne-4-carboxa m ide ;2-(1 H-imidazol-1 -yl-d3)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-methylpyrimidine-4- carboxamide;6-(fluoromethyl)-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2- methoxyethoxy)cyclohexyl ) pyri m id i ne-4-carboxa m ide ;6-(Difluoromethyl)-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2- methoxyethoxy)cyclohexyl ) pyri m id i ne-4-carboxa m ide ;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxy-4-methylcyclohexyl)pyrimidine-4-carboxamide;N-((1 s,4s)-4-hydroxy-4-methylcyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;N-((1 s,4s)-4-hydroxy-4-methylcyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;6-cyclopropyl-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)pyrimidine- 4-carboxamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-4-vinylpicolinamide;N-((1 r,4r)-4-ethoxycyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;4-(difluoromethyl)-6-(1 H-imidazol-1 -yl)-N-((1r, 4r)-4-(2- methoxyethoxy)cyclohexyl)picolinamide;2-(1 H-imidazol-1 -yl)-N-((1s, 4s)-4-(2-methoxyethoxy)cyclohexyl)-6-methylpyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxy-2-methyl propoxy )cyclohexyl)-6- methylpyrimidine-4-carboxamide;6-(1 H-imidazol-1 -yl)-4-methoxy-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)picolinamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrimidine-4-carboxamide;N-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,3r)-3-(2-methoxyethoxy)cyclobutyl)pyrimidine-4-carboxamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-5-(thiazol-5-yl)-1 H-indole-7-carboxamide;N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-5-(1 H-pyrazol-1-yl)-1 H-indole-7-carboxamide;N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-5-(1 H-1 ,2,4-triazol-1 -yl)-1 Hindole-7- carboxamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-5-(5H-tetrazol-5-yl)-1 H-indole7-carboxamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-5-(thiazol-4-yl)-1 H-indole-7-carboxamide;5-(1 H-imidazol-2-yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 H-indole-7- carboxamide;N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-5-(1 H-pyrazol-4-yl)-1 H-indole-7-carboxamide;3-(1 -hydroxyethyl )-5-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1H- indole-7-carboxamide;3-((S)-1-hydroxyethyl)-5-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)- 1 H-indole-7-carboxamide;3-((R)-l-hydroxyethyl)-5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)- 1 H-indole-7-carboxamide;5-(1 H-imidazol-1 -yl )-7-(((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)carbamoyl)-1 H-indole-3- carboxylic acid;5-(1 H-imidazol-1 -yl)-N7-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-N3-methyl-1 H-indole- 3,7-dicarboxamide;5-(1 H-imidazol-1 -yl)-N7-((1r, 4r)-4-(2-methoxyethoxy)cyclohexyl)-N3,N3-dimethyl-1H- indole-3,7-dicarboxamide;5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-3-nitro-1 H-indole-7- carboxamide;3-formyl-5-(1 H-imidazol-1 -yl)-N-((1r, 4r)-4-(2-methoxyethoxy)cyclohexyl)-1H-indole-7- carboxamide;3-((dimethylamino)methyl)-5-(1 H-imidazol-1 -yl)-N-((1r, 4r)-4-(2- methoxyethoxy)cyclohexyl)-1 H-indole-7-carboxamide;3-(aminomethyl)-5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 H- indole-7-carboxamide;3-(hydroxymethyl)-5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 H- indole-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-3-(trifluoromethyl)-1 H- indole-7-carboxamide;3-cyano-N-((1 r,4r)-4-(2-methoxyethoxy )cyclohexyl)-5-(thiazol-5-yl)-1 H-indole-7- carboxamide;3-cyano-5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 H-indole-7- carboxamide;5-(1 H-imidazol-1 -yl)-3-iodo-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 H-indole-7- carboxamide;5-(1 H-imidazol-1 -yl)-N7-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 Hindole-3,7- dicarboxamide;N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-(2-fluoro-6-(trifluoromethyl)benzyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-(2-(methylsulfonyl)ethyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((tetrahydro-2H-pyran-4-yl)methyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1r,3r)-3-(2-methoxyethoxy)cyclobutyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1R,3R)-3-hydroxycyclopentyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1 s,3s)-3-(2-methoxyethoxy )cyclobutyl)-6-(thiazol-5-yl)-1 H-indole-4-carboxamide;N-(4-morpholinobenzyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-(T rans-3-(2-methoxyethoxy )cyclopentyl)-6-(thiazol-5-yl)-1 H-indole-4-carboxamide;N-(piperidin-4-yl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide hydrochloride;N-(3-hydroxy-3-methylcyclobutyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1r,4r)-4-(3-methoxypropoxy)cyclohexyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-(1-(2-fluorophenyl)ethyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1R,2S)-2-methylcyclohexyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1r,4r)-4-hydroxycyclohexyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-(1 -methoxy-2-methyl propan-2-yl)-6-(thiazol-5-yl)-1 H-indole-4-carboxamide;N-(2-hydroxy-2-methylpropyl)-6-(thiazol-5-yl)-1 H-indole-4-carboxamide;N-(adamantan-1 -yl )-6-(th iazol -5-yl )- 1 H-indole-4-carboxamide;N-(tetrahydro-2H-pyran-4-yl)-6-(thiazol-5-yl)-1 H-indole-4-carboxamide;N-((1r,3r)-3-hydroxycyclobutyl)-6-(thiazol-5-yl)-1H-indole-4-carboxamide;N-((1 s,4s)-4-(2-methoxyethoxy )cyclohexyl)-6-(thiazol-5-yl)-1 H-indole-4-carboxamide;Methyl-5-(1 H-imidazol-1 -yl )-7-(((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)carbamoyl)-1 H- indole-3-carboxylate;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1-(oxetan-3-ylmethyl)-6-(thiazol-5-yl)-1 H- indole-4-carboxamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1-methyl-6-(thiazol-5-yl)-1H-indole-4- carboxamide;1-isopropyl-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(thiazol-5-yl)-1H-indole-4- carboxamide;1-(2-hydroxy-2-methyl propyl )-N-((1r, 4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(thiazol-5-yl)- 1 H-indole-4-carboxamide;5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 -methyl-1 H-indole-7- carboxamide;7-fluoro-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(thiazol-5-yl)-1 H-indole-4- carboxamide;3-cyano-6-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 H-indole-4- carboxamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-3-methyl-6-(thiazol-5-yl)-1H-indole-4- carboxamide;N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-(thiazol-5-yl)-1 H-pyrrolo[2,3-b]pyridine-4- carboxamide;5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 Hpyrrolo[2,3-c]pyridine- 7-carboxamide;N-((1 r,4r)-4-(2-methoxyethoxy )cyclohexyl)-5-(thiazol-5-yl)-1 H-pyrrolo[3,2-b]pyridine-7- carboxamide;4,6-di(1 H-imidazol-1-yl)-N-((1r,4r)-4-methoxycyclohexyl)picolinamide;6-chloro-4-(1 H-imidazol-1-yl)-N-((1r,4r)-4-methoxycyclohexyl)picolinamide;4-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-6-oxo-1 ,6-dihydropyridine-2- carboxamide;6-(1 H-imidazol-1 -yl)-4-methoxy-N-((1 r,4r)-4-methoxycyclohexyl)picolinamide;4-hydroxy-6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)picolinamide;2-acetamido-N-((1r,4r)-4-methoxycyclohexyl)-5-(thiazol-5-yl)benzamide;2-amino-N-((1r,4r)-4-methoxycyclohexyl)-5-(thiazol-5-yl)benzamide;2-fluoro-N-((1r,4r)-4-methoxycyclohexyl)-3-(thiazol-5-yl)benzamide;N-((1r,4r)-4-methoxycyclohexyl)-6-(thiazol-5-yl)pyrazine-2-carboxamide;3-amino-6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)pyridazine-4-carboxamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrazine-2-carboxamide;N-((1r,4r)-4-methoxycyclohexyl)-6-(thiazol-5-yl)picolinamide;N-((1r,4r)-4-methoxycyclohexyl)-6-(1 H-pyrazol-5-yl)pyrazine-2-carboxamide;N-((1r,4r)-4-methoxycyclohexyl)-6-(1 H-pyrazol-4-yl)pyrazine-2-carboxamide;6-(isoxazol-4-yl)-N-((1r,4r)-4-methoxycyclohexyl)pyrazine-2-carboxamide;N-((1r,4r)-4-methoxycyclohexyl)-6-(pyridin-4-yl)pyrazine-2-carboxamide;6-(isoxazol-5-yl)-N-((1r,4r)-4-methoxycyclohexyl)picolinamide;N-((1r,4r)-4-methoxycyclohexyl)-6-(4H-1 ,2,4-triazol-4-yl)pyrazine-2-carboxamide;N-((1r,4r)-4-methoxycyclohexyl)-6-(1 ,3,4-oxadiazol-2-yl)pyrazine-2-carboxamide;5-amino-6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)picolinamide;2-amino-6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)pyrimidine-4-carboxamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-2-(methylamino)pyrimidine-4- carboxamide;6-(dimethylamino)-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-6-(methylamino)pyrimidine-4- carboxamide;6-amino-2-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1r, 4r)-4-methoxycyclohexyl)-6-(piperidin-1-yl)pyrimidine-4- carboxamide;3-amino-N-((1r,4r)-4-methoxycyclohexyl)-6-(thiazol-5-yl)pyrazine-2-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyridazine-3-carboxamide;N-cyclohexyl-6-(1 H-imidazol-1 -yl)pyrazine-2-carboxamide;6-(1 H-imidazol-1 -yl)-N-isopropylpyrazine-2-carboxamide;6-(1 H-imidazol-1 -yl)-N-(tetrahydro-2H-pyran-4-yl)pyrazine-2-carboxamide;6-(1 H-imidazol-1 -yl)-N-(piperidin-4-yl)pyrazine-2-carboxamide;N-(tert-butyl)-6-(1 H-imidazol-1 -yl)pyrazine-2-carboxamide;6-(1 H-imidazol-1 -yl)-N-phenylpyrazine-2-carboxamide;6-(1 H-imidazol-1 -yl)-N-(1-methylpiperidin-4-yl)pyrazine-2-carboxamide;N-(cyclohexylmethyl)-6-(1 H-imidazol-1 -yl)pyrazine-2-carboxamide;N-benzyl-6-(1 H-imidazol-1 -yl)pyrazine-2-carboxamide;N-(1-cyclohexylethyl)-6-(1 H-imidazol-1 -yl)pyrazine-2-carboxamide;N-(1-acetylpiperidin-4-yl)-6-(1H-imidazol-1-yl)pyrazine-2-carboxamide;3-amino-6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)pyrazine-2-carboxamide;3-amino-N-cyclohexyl-6-(1 H-imidazol-1-yl)pyrazine-2-carboxamide;3-(dimethylamino)-6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrazine-2- carboxamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-3-(methylamino)pyrazine-2- carboxamide;4-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-6-methylpicolinamide;4-chloro-6-(1 H-imidazol-1-yl)-N-((1r,4r)-4-methoxycyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-4-methylpicolinamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-4-(trifluoromethyl)picolinamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)nicotinamide;2-amino-5-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)nicotinamide;3-amino-6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)picolinamide;3-amino-N-cyclohexyl-6-(1 H-imidazol-1 -yl)picolinamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)isonicotinamide;4-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)picol inamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrimidine-4-carboxamide;N-cyclooctyl-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)pyrimidine-4-carboxamide;3-hydroxy-6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrazine-2-carboxamide;2-hydroxy-5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)nicotinamide;5-amino-2-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)isonicotinamide;N-((1 r,4r)-4-methoxycyclohexyl)-6-(1 H-1 ,2,4-triazol-1 -yl)pyrazine-2-carboxamide;3-hydroxy-6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)picolinamide;N-cyclohexyl-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;4-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrimidine-2-carboxamide;6-(1 H-imidazol-1 -yl)-5-methoxy-N-((1 r,4r)-4-methoxycyclohexyl)picolinamide;3-chloro-6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)picolinamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-5-methylpicolinamide;5-chloro-6-(1 H-imidazol-1 -yl)-N-((1r,4r)-4-methoxycyclohexyl)picolinamide;N-cyclohexyl-6-(4-methyl-1H-imidazol-1-yl)pyrazine-2-carboxamide;N-cyclohexyl-6-(5-methyl-1H-imidazol-1-yl)pyrazine-2-carboxamide;N-cyclohexyl-6-(2-methyl-1H-imidazol-1-yl)pyrazine-2-carboxamide;2-(1H-imidazol-1-yl)-N-phenylpyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(o-tolyl)pyrimidine-4-carboxamide;N-(2-fluorophenyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide;N-(2-chlorophenyl)-2-(1H-imidazol-1-yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(2-methoxyphenyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(p-tolyl)pyrimidine-4-carboxamide;N-(4-fluorophenyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide;N-(4-chlorophenyl)-2-(1H-imidazol-1-yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(4-(trifluoromethyl)phenyl)pyrimidine-4-carboxamide;N-(4-cyanophenyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(m-tolyl)pyrimidine-4-carboxamide;N-(3-fluorophenyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide;N-(3-chlorophenyl)-2-(1H-imidazol-1-yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(thiazol-5-yl)pyrimidine-4-carboxamide;N-cyclopentyl-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;N-cycloheptyl-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-6-methylpyrimidine-4-carboxamide;N-((1 r,4r)-4-methoxycyclohexyl)-2-(1 H-pyrazol-1 -yl)pyrimidine-4-carboxamide;N-(3-fluorophenyl)-2-(1 H-imidazol-1 -yl)-6-(piperidin-1-yl)pyrimidine-4-carboxamide;N-(3-fluorophenyl)-2-(1 H-pyrazol-1 -yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;6-cyclobutoxy-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-6-methoxy-N-((1 r,4r)-4-methoxycyclohexyl)pyrimidine-4- carboxamide;6-cyano-2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)pyrimidine-4- carboxamide;N-(4,4-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methylcyclohexyl)pyrimidine-4-carboxamide;N-(4,4-difluorocyclohexyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(pyridin-4-yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(pyridin-2-yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1s,4s)-4-methylcyclohexyl)pyrimidine-4-carboxamide;N-(3-fluorophenyl)-2-(1 H-imidazol-1-yl)-6-morpholinopyrimidine-4-carboxamide;N-(3-fluorophenyl)-2-(1 H-imidazol-1 -yl)-5-(piperidin-1-yl)pyrimidine-4-carboxamide;N-(3-fluorophenyl)-2-(1 H-pyrazol-5-yl)pyrimidine-4-carboxamide;N-(3-fluorophenyl)-2-(1 H-imidazol-1 -yl)-N-methyl-6-(piperidin-1 -yl)pyrimidine-4- carboxamide;N-(2,6-difluorophenyl)-2-(1 H-imidazol-1 -yl )-6-(pi peridin-1 -yl)pyrimidine-4-carboxamide;N-benzyl-2-(1 H-imidazol-1 -yl)-6-(piperidin-1-yl)pyrimidine-4-carboxamide;N-(3-fluorophenyl)-2-(1 H-imidazol-1-yl)-6-(pyrrolidin-1-yl)pyrimidine-4-carboxamide;6-cyclobutoxy-N-(3-fluorophenyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide;N-(3-fluorophenyl)-2-(1 H-imidazol-1-yl)-6-(oxetan-3-yloxy)pyrimidine-4-carboxamide;N-(3-fluorophenyl)-2-(1 H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(3-chlorophenyl)-2-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(3,4-difluorophenyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;N-(3,5-difluorophenyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;N-(4-chloro-3-fluorophenyl)-2-(1 H-imidazol-1 -yl)pyrimidine-4-carboxamide;4-(4,4-dimethylpiperidin-1-yl)-N-(3-fluorophenyl)-6-(1 H-imidazol-1 -yl)picolinamide;N-(3-fluorophenyl)-6-(1 H-imidazol-1 -yl)-4-(piperidin-1-yl)picolinamide;N-cyclohexyl-6-(1 H-imidazol-1 -yl)-4-(piperidin-1-yl)picolinamide;N-(3-fluorophenyl)-6-(1 H-imidazol-1-yl)-4-isopropylpicolinamide;N-(3-fluorophenyl)-2-(1 H-imidazol-1-yl)-6-isopropylpyrimidine-4-carboxamide;N-(3-fluorophenyl)-6-(1 H-imidazol-1-yl)-4-(trifluoromethyl)picolinamide;N-(3,4-difluorophenyl)-2-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(2,5-difluorophenyl)-2-(1 H-imidazol-1 -yl )-6-(pi peridin-1 -yl)pyrimidine-4-carboxamide;N-(2-chloro-5-fluorophenyl)-2-(1 H-imidazol-1 -yl )-6-( piperidin-1 -yl)pyrimidine-4- carboxamide;N-(5-fluoro-2-methylphenyl)-2-(1 H-imidazol-1 -yl )-6-(pi peridin-1 -yl)pyrimidine-4- carboxamide;N-(4,4-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-(1-methylcyclohexyl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-cyclohexyl-2-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(tert-butyl)-2-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(4,4-dimethylcyclohexyl)-2-(1 H-imidazol-1 -yl )-6-( piperidin-1 -yl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-(1-methylcyclohexyl)-6-(piperidin-1-yl)pyrimidine-4-carboxamide;N-cyclohexyl-2-(1 H-imidazol-1 -yl)-6-(piperidin-1-yl)pyrimidine-4-carboxamide;N-(tert-butyl)-2-(1 H-imidazol-1 -yl)-6-(piperidin-1-yl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-methylcyclohexyl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-methylcyclohexyl)-6-(piperidin-1 -yl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-methylcyclohexyl)-6-morpholinopyrimidine-4- carboxamide;6-cyclobutoxy-2-(1 H-imidazol-1 -yl )-N-((1 r,4r)-4-methylcyclohexyl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methylcyclohexyl)-6-(oxetan-3-yloxy)pyrimidine-4- carboxamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-3-(trifluoromethyl)picolinamide;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-5-(trifluoromethyl)picolinamide;N-((1 r,4r)-4-methoxycyclohexyl)-2-(4-(trifluoromethyl)-1 H-imidazol-1 -yl)pyrimidine-4- carboxamide;N-((1 r,4r)-4-methoxycyclohexyl)-2-(2-(trifluoromethyl)-1 H-imidazol-1 -yl)pyrimidine-4- carboxamide;N-((1 r,4r)-4-methoxycyclohexyl)-6-(4-(trifluoromethyl)-1 H-imidazol-1 -yl)picolinamide;N-((1 r,4r)-4-methoxycyclohexyl)-6-(2-(trifluoromethyl)-1 H-imidazol-1 -yl)picolinamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6- (trifl uoro methyl ) pyri m id i ne-4-carboxa m ide ;6-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methylcyclohexyl)-4-(trifluoromethyl)picolinamide;N-(3-fluorophenyl)-6-(1 H-imidazol-1-yl)-3-(trifluoromethyl)picolinamide;N-(3-fluorophenyl)-6-(1 H-imidazol-1-yl)-5-(trifluoromethyl)picolinamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-5-(trifluoromethyl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-(piperidin-4-yl)-6-(trifluoromethyl)pyrimidine-4- carboxamidehydrochloride;2-(1 H-imidazol-1 -yl)-N-(tetrahydro-2H-pyran-4-yl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;N-(6-cyanopyridin-3-yl)-2-(1 H-imidazol-1 -yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(4-cyanophenyl)-2-(1 H-imidazol-1 -yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(5-fluoropyridin-3-yl)-2-(1 H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(pyridin-4-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(5-cyanopyridin-3-yl)-2-(1 H-imidazol-1 -yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(pyrimidin-5-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;2-(1H-imidazol-1-yl)-N-(pyridazin-4-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(4-fluorophenyl)-2-(1 H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(3,4-difluorophenyl)-2-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(3,5-difluorophenyl)-2-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide;N-(3-fluoro-5-(piperazin-1 -yl)phenyl)-2-(1 H-imidazol-1 -yl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;N-(3-fluoro-5-morpholinophenyl)-2-(1 H-imidazol-1 -yl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-(3-morpholinophenyl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;(S)-N-(3-fluoro-5-(3-hydroxypyrrolidin-1-yl)phenyl)-2-(1 H-imidazol-1 -yl)-6-(trifl uoro methyl ) pyri m id i ne-4-carboxa m ide ;N-(3-fluoro-5-(2-methoxypropan-2-yl)phenyl)-2-(1 H-imidazol-1-yl)-6-(trifl uoro methyl ) pyri m id i ne-4-carboxa m ide ;N-(3-fluoro-4-(2-hydroxypropan-2-yl)phenyl)-2-(1H-imidazol-1-yl)-6-(trifl uoro methyl ) pyri m id i ne-4-carboxa m ide ;N-(3-(2-(dimethylamino)ethoxy)-5-fluorophenyl)-2-(1 H-imidazol-1 -yl)-6-(trifl uoro methyl ) pyri m id i ne-4-carboxa m ide ;N-(3-fluoro-5-(2-methoxyethoxy)phenyl)-2-(1 H-imidazol-1 -yl)-6-(trifl uoro methyl ) pyri m id i ne-4-carboxa m ide ;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-6-(pyridin-4-yl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-6-(2-(trifluoromethyl)pyridin-4- yl )pyri m id i ne-4-carboxa m ide ;6-cyano-N-(3-fluorophenyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide6-cyano-2-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)pyrimidine-4-carboxamide;6-cyano-N-(4-fluorophenyl)-2-(1 H-imidazol-1-yl)pyrimidine-4-carboxamide2-(1 H-imidazol-1 -yl)-N-(2-(2-methoxyethoxy)pyrimidin-5-yl)-6-(trifluoromethyl)pyrimidine- 4-carboxamide;6-cyano-2-(1H-imidazol-1-yl)-N-(pyrimidin-5-yl)pyrimidine-4-carboxamide;6-(1H-imidazol-1-yl)-N-(pyridin-4-yl)-4-(trifluoromethyl)picolinamide;6-(1H-imidazol-1-yl)-N-(pyridin-3-yl)-4-(trifluoromethyl)picolinamide;6-(1H-imidazol-1-yl)-N-(pyrimidin-5-yl)-4-(trifluoromethyl)picolinamide;N-(2-(2-hydroxyethoxy)pyrimidin-5-yl)-2-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine- 4-carboxamide;2-((5-(2-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamido)pyrimidin-2- yl)oxy)aceticacid;N-(2-hydroxypyrimidin-5-yl)-2-(1H-imidazol-1-yl)-6-(trifluoromethyl)pyrimidine-4- carboxamide;N-cyclohexyl-4-oxo-2-(pyridin-4-yl)-3,4-dihydrothieno[3,2-d]pyrimidine-7-carboxamide;4-amino-N-cyclohexyl-2-(pyridin-4-yl)thieno[3,2-d]pyrimidine-7-carboxamide;N-((1S,2S)-1 -hydroxy-2, 3-dihydro-1H-inden-2-yl)-4-oxo-2-(pyridin-4-yl)-3, 4- dihydrothieno[3,4-d]pyrimidine-7-carboxamide;N-(2,3-dihydro-1H-inden-2-yl)-4-oxo-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4-d] pyrimidine- 7-carboxamide;4-oxo-2-(pyridin-4-yl)-N-((2R)-5-((tetrahydrofuran-3-yl)oxy)-2,3-dihydro-1H-inden-2-yl)- 3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxamide;N-cyclohexyl-4-oxo-2-(thiazol-5-yl)-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxamide;N-cyclohexyl-2-methyl-4-oxo-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxamide;N-cyclohexyl-4-oxo-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxamide;4-oxo-2-(pyridin-4-yl)-N-(tetrahydro-2H-pyran-4-yl)-3,4-dihydrothieno[3,4-d]pyrimidine-7- carboxamide;N-((1r,4r)-4-hydroxycyclohexyl)-4-oxo-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4-d]pyrimidine- 7-carboxamide;N-benzyl-4-oxo-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxamide;4-oxo-N-phenethyl-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxamide;4-oxo-N-(pyridin-3-ylmethyl)-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4-d]pyrimidine-7- carboxamide;N-(5-ethoxy-2,3-dihydro-1H-inden-2-yl)-4-oxo-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4- d]pyrimidine-7-carboxamide;N-cyclohexyl-4-oxo-2-phenyl-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxamide;N-cyclohexyl-4-oxo-2-(pyridin-3-yl)-3,4-dihydrothieno[3,4-d]pyrimidine-7-carboxamide;N-(1-cyclohexylethyl)-4-oxo-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4-d]pyrimidine-7- carboxamide;N-(bicyclo[2.2.2]octan-1-yl)-4-oxo-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4-d]pyrimidine-7- carboxamide;N-(1-cyclohexyl-2-hydroxyethyl)-4-oxo-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4- d]pyrimidine-7-carboxamide; methyl2-cyclohexyl-2-(4-oxo-2-(pyridin-4-yl)-3,4-dihydrothieno[3,4-d]pyrimidine-7- carboxamido)acetate;N-cyclohexyl-5-(pyridin-4-yl)benzo[d]isoxazole-3-carboxamide;N-cyclohexyl-2-(pyridin-4-yl)-1H-indole-4-carboxamide;N-cyclohexyl-3-(pyridin-4-yl)-1H-indole-5-carboxamide;N-cyclohexyl-3-(pyridin-4-yl)-1H-indazole-5-carboxamide;N-((1r,4r)-4-methoxycyclohexyl)-3-(thiazol-5-yl)-1H-indazole-5-carboxamide;N-cyclohexyl-2-(pyridin-4-yl)-1H-benzo[d]imidazole-4-carboxamide;N-cyclohexyl-8-(pyridin-4-yl)-9H-purin-6-amine;N-cyclohexyl-7-(pyridin-4-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amine;N-cyclohexyl-7-(thiazol-5-yl)thieno[3,2-d]pyrimidin-2-amine;N-cyclohexyl-6-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;N-cyclohexyl-6-(thiazol-5-yl)thieno[2,3-d]pyrimidin-4-amine;2-(cyclohexylamino)-7-(1H-imidazol-1-yl)thieno[3,2-d]pyrimidin-4(3H)-one;N-cyclohexyl-5-(thiazol-5-yl)-1H-indazol-3-amine;1-(3-(cyclohexylamino)-5-(thiazol-5-yl)-1 H-indazol-1-yl)ethanone;N-cyclohexyl-1-methyl-5-(thiazol-5-yl)-1H-indazol-3-amine;N-cyclohexyl-5-(pyridin-4-yl)-1 H-indazol-3-amine;N-cyclohexyl-5-(pyrazin-2-yl)-1 H-indazol-3-amine;N-(cyclohexylmethyl)-5-(thiazol-5-yl)-1 H-indazol-3-amine;N-cyclohexyl-7-(thiazol-5-yl)benzo[d]oxazol-2-amine;4-(((1r,4r)-4-methoxycyclohexyl)amino)-1-methyl-6-(1H-pyrazol-4-yl)quinolin-2(1H)-one;N-(5-(thiazol-5-yl)-1 H-indazol-3-yl)cyclohexanecarboxamide;N-cyclohexyl-2-oxo-3-(pyridin-4-yl)-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide;N-(1-(pyridin-4-yl)-1 H-benzo[d]imidazol-6-yl)cyclohexanecarboxamide; methyl 5-(6-(1 H-imidazol-1-yl)picolinamido)picolinate;5-(6-(1H-imidazol-1-yl)picolinamido)-N-methylpicolinamide;N-(6-carbamoylpyridin-3-yl)-6-(1H-imidazol-1-yl)picolinamide;N-(2-cyano-6-methylpyridin-4-yl)-6-(1H-imidazol-1-yl)picolinamide;N-(2,6-difluoropyridin-4-yl)-6-(1 H-imidazol-1-yl)picolinamide; ethyl 4-(6-(1 H-imidazol-1-yl)picolinamido)picolinate;N-(2,6-dimethylpyridin-4-yl)-6-(1 H-imidazol-1-yl)picolinamide;N-(2-fluoropyridin-4-yl)-6-(1 H-imidazol-1-yl)picolinamide;6-(1H-imidazol-1-yl)-N-(6-(trifluoromethyl)pyridin-3-yl)picolinamide;6-(1H-imidazol-1-yl)-N-(2-((2-methoxyethyl)amino)pyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(2-methylpyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(2-methoxypyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(pyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(6-methylpyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(6-(N-methylacetamido)pyridin-3-yl)picolinamide;N-(6-acetamidopyridin-3-yl)-6-(1 H-imidazol-1 -yl)picolinamide;N-(2-carbamoylpyridin-4-yl)-6-(1 H-imidazol-1 -yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(6-methoxypyridin-3-yl)picolinamide;N-(6-(N-ethylacetamido)pyridin-3-yl)-6-(1H-imidazol-1-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)picolinamide;5-(6-(1 H-imidazol-1 -yl)picolinamido)picolinic acid;N-(6-fluoropyridin-3-yl)-6-(1 H-imidazol-1 -yl)picolinamide;4-(6-(1 H-imidazol-1 -yl)picolinamido)-N-methylpicolinamide;6-(1 H-imidazol-1 -yl)-N-(pyrimidin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-N-(pyridin-2-yl)picolinamide;6-(5-methyl-1 H-imidazol-1 -yl)-N-(pyridin-3-yl)picolinamide; methyl 5-(6-(1 H-imidazol-1 -yl)picolinamido)picolinate;6-(1 H-imidazol-1 -yl)-N-(2-(trifluoromethyl)pyridin-4-yl)picolinamide;4-(benzyloxy)-6-(1 H-imidazol-1 -yl)-N-(2-(trifluoromethyl)pyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-((tetrahydro-2H-pyran-4-yl)methoxy)-N-(2-(trifluoromethyl)pyridin- 4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-(2-methoxyethoxy)-N-(2-(trifluoromethyl)pyridin-4-yl)picolinamide;4-cyclopropoxy-6-(1 H-imidazol-1-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)picolinamide;4-(2-(dimethylamino)ethoxy)-6-(1 H-imidazol-1 -yl)-N-(2-(trifluoromethyl)pyridin-4- yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-((3-methyloxetan-3-yl)oxy)-N-(2-(trifluoromethyl)pyridin-4- yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-methoxy-N-(2-(trifluoromethyl)pyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-methoxy-N-(pyridin-3-yl)picolinamide;2-(1 H-imidazol-1 -yl)-6-methoxy-N-(2-(trifluoromethyl)pyridin-4-yl)pyrimidine-4- carboxamide;6-ethoxy-2-(1H-imidazol-1-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)pyrimidine-4- carboxamide;2-(1H-imidazol-1-yl)-6-(2-methoxyethoxy)-N-(2-(trifluoromethyl)pyridin-4-yl)pyrimidine-4- carboxamide;6-cyclopropoxy-2-(1H-imidazol-1-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-6-((3-methyloxetan-3-yl)oxy)-N-(2-(trifluoromethyl)pyridin-4- yl )pyri m id i ne-4-carboxa m ide ;6-(1-methyl-1H-imidazol-5-yl)-N-(pyridin-3-yl)picolinamide;6-(1-methyl-1H-imidazol-5-yl)-N-(6-(trifluoromethyl)pyridin-3-yl)picolinamide;4-methyl-6-(1-methyl-1H-imidazol-5-yl)-N-(pyridin-4-yl)picolinamide;4-methyl-6-(1-methyl-1H-imidazol-2-yl)-N-(pyridin-4-yl)picolinamide;6-(thiazol-5-yl)-N-(6-(trifluoromethyl)pyridin-3-yl)picolinamide;6-(1-methyl-1H-imidazol-2-yl)-N-(6-(trifluoromethyl)pyridin-3-yl)picolinamide;6-(1-methyl-1H-imidazol-2-yl)-N-(pyridin-3-yl)picolinamide;2-(1H-imidazol-1-yl)-6-methyl-N-(pyridin-3-yl)pyrimidine-4-carboxamide;2-(1H-imidazol-1-yl)-6-methyl-N-(pyridin-4-yl)pyrimidine-4-carboxamide;6-cyclopropyl-2-(1 H-imidazol-1 -yl)-N-(2-(trifluoromethyl)pyridin-4-yl)pyrimidine-4- carboxamide;6-(1 H-imidazol-1 -yl)-4-methyl-N-(pyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-methyl-N-(pyridin-3-yl)picolinamide;N-(6-carbamoylpyridin-3-yl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;N-(2-carbamoylpyridin-4-yl)-6-(1 H-imidazol-1 -yl)-4-methylpicolinamide;6-(1 H-imidazol-1 -yl)-4-methyl-N-(2-(methylcarbamoyl)pyridin-4-yl)picolinamide;6-(1 H-imidazol-1 -yl)-4-methyl-N-(6-(methylcarbamoyl)pyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-5-methyl-N-(pyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-3-methyl-N-(pyridin-3-yl)picolinamide;6-(1 H-imidazol-1 -yl)-5-methoxy-N-(pyridin-3-yl)picolinamide;5-fluoro-6-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)picolinamide;-fluoro-6-(1 H-imidazol-1-yl)-N-(pyridin-3-yl)picolinamide; -(1 H-imidazol-1 -yl)-3-methoxy-N-(pyridin-3-yl)picolinamide; -amino-6-(1 H-imidazol-1-yl)-N-(pyridin-4-yl)picolinamide; -amino-N-(2-fluoropyridin-4-yl)-6-(1 H-imidazol-1 -yl)picolinamide; -amino-6-(1 H-imidazol-1-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)picolinamide; -amino-6-(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)picolinamide; -(1 H-imidazol-1 -yl)-4-(methylamino)-N-(pyridin-3-yl)picolinamide; -(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)pyrimidine-4-carboxamide; -(1 H-imidazol-1 -yl)-N-(pyridin-3-yl)pyrazine-2-carboxamide; -(1 H-imidazol-1 -yl)-2-((3-methyloxetan-3-yl)oxy)-N-(2-(trifluoromethyl)pyridin-4- yl )pyri m id i ne-4-carboxa m ide ; -(1 H-imidazol-1 -yl)-6-((tetrahydro-2H-pyran-4-yl)methoxy)-N-(2-(trifluoromethyl)pyridin- 4-yl)pyrimidine-4-carboxamide; -(1-methyl-1H-imidazol-5-yl)-6-((tetrahydro-2H-pyran-4-yl)methoxy)-N-(2- (trifluoromethyl)pyridin-4-yl)pyrimidine-4-carboxamide; -(1-methyl-1H-imidazol-2-yl)-6-((tetrahydro-2H-pyran-4-yl)methoxy)-N-(2- (trifluoromethyl)pyridin-4-yl)pyrimidine-4-carboxamide; -(2-methoxyethoxy)-2-(1-methyl-1H-imidazol-5-yl)-N-(2-(trifluoromethyl)pyridin-4- yl )pyri m id i ne-4-carboxa m ide ; -(2-methoxyethoxy)-2-(1-methyl-1H-imidazol-2-yl)-N-(2-(trifluoromethyl)pyridin-4- yl )pyri m id i ne-4-carboxa m ide ; -(2-methoxyethoxy)-2-(1-methyl-1H-pyrazol-5-yl)-N-(2-(trifluoromethyl)pyridin-4- yl )pyri m id i ne-4-carboxa m ide ; -(2-hydroxy-2-methyl propoxy )-2-(1 H-imidazol-1-yl)-N-(2-(trifluoromethyl)pyridin-4- yl )pyri m id i ne-4-carboxa m ide ; -(1 H-imidazol-1 -yl)-N-(pyridin-4-yl)pyrimido[5,4-d]pyrimidin-4-amine; -(1-methyl-1H-imidazol-5-yl)-6-((3-methyloxetan-3-yl)oxy)-N-(2-(trifluoromethyl)pyridin- 4-yl)pyrimidine-4-carboxamide;2-(1-methyl-1H-imidazol-2-yl)-6-((3-methyloxetan-3-yl)oxy)-N-(2-(trifluoromethyl)pyridin- 4-yl)pyrimidine-4-carboxamide;2-(1-methyl-1H-pyrazol-5-yl)-6-((3-methyloxetan-3-yl)oxy)-N-(2-(trifluoromethyl)pyridin-4- yl )pyri m id i ne-4-carboxa m ide ;4-(((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-1-methyl-7-(thiazol-5-yl)quinolin- 2(1H)-one;4-(((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin- 2(1H)-one;1-ethyl-4-(((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-6-(thiazol-5-yl)quinolin-2(1H)- one;4-(((1r,4r)-4-methoxycyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one;4-(((1 r,4r)-4-hydroxycyclohexyl)amino)-1 -methyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;4-(((1 r,4r)-4-methoxycyclohexyl)amino)-1 ,8-dimethyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;4-(((1r,4r)-4-(aminomethyl)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)- one;4-(((1 r,4r)-4-aminocyclohexyl)amino)-1 -methyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;1-methyl-4-(piperidin-4-ylamino)-6-(thiazol-5-yl)quinolin-2(1H)-one;1-methyl-4-((tetrahydro-2H-pyran-4-yl)amino)-6-(thiazol-5-yl)quinolin-2(1H)-one;6-methoxy-1-methyl-4-(piperidin-4-ylamino)quinolin-2(1H)-one;4-amino-1 -methyl-6-(thiazol-5-yl)quinolin-2(1 H)-one;4-((1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-yl)amino)-6-chloro-1-(thiazol-5- yl methyl )quinolin-2(1 H)-one;4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)-2-methylquinoline-8-carboxamide;2-methyl-4-((2,3,6-trichlorobenzyl)amino)quinoline-8-carboxamide;4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid; potassium 4,5-dihydroxy-9, 10-dioxo-9, 10-dihydroanthracene-2-carboxylate;5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one;-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)chromenylium; -((2R,3S,4S,5R)-5-((((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4- dihydroxytetrahydrofuran-2- yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-3,4- dihydroxytetrahydrofuran-2-yl)-3-carbamoylpyridin-1-ium; -((2R,3S,4R,5R)-5-((((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4- dihydroxytetrahydrofuran-2- yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-3-fluoro-4- hyd roxytetrahyd rof u ra n-2-y I )-3-ca rba moy I py rid i n- 1 -i u m ; -carbamoyl-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-((phosphonooxy)methyl)tetrahydrofuran-2-yl)pyridin-1-ium; -((1 R,2S,3R,4R)-4-((((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4- dihydroxytetrahydrofuran-2- yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-2,3- dihydroxycyclopentyl)-3-carbamoylpyridin-1-ium; -carbamoyl-1-((2R,3R,4S,5R)-5-((((((((2R,3S,4R,5R)-5-(2-fluoro-6-imino-1,6- dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2- yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-3,4- dihydroxytetrahydrofuran-2-yl)pyridin-1-ium; -carbamoyl-1-((2R,3S,4S,5R)-5-((((((((2R,3S,4R,5R)-5-(2-fluoro-6-imino-1 ,6- dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2- yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-3,4- dihydroxytetrahydrofuran-2-yl)pyridin-1-ium; -carbamoyl-1-((2R,3S,4R,5R)-5-((((((((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-imino-1,6- dihydro-9H-purin-9-yl)tetrahydrofuran-2- yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-3-fluoro-4- hyd roxytetrahyd rof u ra n-2-y I )py rid i n- 1 -i u m ; -carbamoyl-1-((2R,3R,4R,5R)-5-((((((((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-imino-1 ,6- dihydro-9H-purin-9-yl)tetrahydrofuran-2- yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-3-fluoro-4- hyd roxytetrahyd rof u ra n-2-y I )py rid i n- 1 -i u m ;(1R,3S)-1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2, 3,4,9- tetrahydro-1 H-pyrido[3,4-b]indole-3-carboxylic acid;5-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1H-benzo[d]imidazole-7- carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-5-(1H-imidazol-1-yl)-1H-benzo[d]imidazole-7- carboxamide;N-[[2-Fluoro-6-(trifluoromethyl)phenyl]methyl]-6-thiazol-5yl-3H-benzimidazole-4- carboxamide;N-((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-5-(thiazol-5-yl)-1H-benzo[d]imidazole-7- carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-5-(1H-imidazol-1-yl)-1H-indole-7-carboxamide;N-((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-5-(thiazol-5-yl)-1H-indole-7-carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;5-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1H-indazole-7- carboxamide;5-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2-methyl-1H-indole-7- carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 H-pyrrolo[3,2- b]pyridine-7-carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-2-methyl-5-(thiazol-5-yl)-1H-indole-7-carboxamide;5-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1H-pyrrolo[2,3- c] pyrid i ne-7 -carboxa m ide;N-((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-2-methyl-5-(thiazol-5-yl)-1H- benzo[d]imidazole-7-carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-7H-purine-6- carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-5-(1H-imidazol-1-yl)-1H-pyrazolo[4,3-b]pyridine-7- carboxamide;5-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-5-(thiazol-5-yl)-1H-pyrazolo[4,3-b]pyridine-7- carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)thieno[3,2-d]pyrimidine-4- carboxamide;2-(Aminomethyl)-5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 H- indole-7-carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-2-(thiazol-5-yl)thieno[3,2-d]pyrimidine-4- carboxamide;N-((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-5-(thiazol-5-yl)-1H-pyrazolo[3,4-c]pyridine-7- carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-5-methyl-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;5-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;5-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)thieno[3,2-b]pyridine-7- carboxamide;5-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)thiazolo[4,5-d]pyrimidine-7-carboxamide;6-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-3H-imidazo[4,5- c] pyrid i ne-4-carboxa m ide;2-(1H-lmidazol-1-yl)-N-(tetrahydro-2H-pyran-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;(S)-2-(1H-lmidazol-1-yl)-N-(tetrahydro-2H-pyran-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;(R)-2-(1H-imidazol-1-yl)-N-(tetrahydro-2H-pyran-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;4-Fluoro-5-(1 H-imidazol-1 -yl)-N-((1r, 4r)-4-(2-methoxyethoxy)cyclohexyl)-1 H-indole-7- carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2-methyl-1 H- benzo[d]imidazole-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2-methyl-1 H- benzo[d]imidazole-7-carboxamide;N-((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-2-(thiazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-(thiazol-5-yl)-3l-imidazo[4,5-c]pyridine-4- carboxamide;N-((1 r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-2-(2-methyl-1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-2-(5-methyl-1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2-(4-methyl-1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1H-lmidazol-4-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-((1s,4s)-4-(trifluoromethyl)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(trifluoromethyl)cyclohexyl)-5H-pyrrolo[3,2-d]pyrimidine- 4-carboxamide;5-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)benzo[d]isothiazole-7- carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-5-(1 H-imidazol-1 -yl)-2-methyl-1H- benzo[d]imidazole-7-carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-2-(thiazol-5-yl)- 5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrrolo[3,2-b]pyridine-7- carboxamide;N-((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-2-methyl-5-(thiazol-5-yl)-1H-indole-7- carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-2-(1H-imidazol-1-yl)-7H-purine-6-carboxamide;N-((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-6-(thiazol-5-yl)-3H-imidazo[4,5-c]pyridine-4- carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-5-(1H-imidazol-1-yl)-1H-pyrazolo[3,4-c]pyridine-7- carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-2-(1H-imidazol-1-yl)thieno[3,2-d]pyrimidine-4- carboxamide;N-((1r,4r)-4-(2-Methoxyethoxy)cyclohexyl)-2-(thiazol-5-yl)thieno[3,2-d]pyrimidine-4- carboxamide;N-(2-Fluoro-6-(trifluoromethyl)benzyl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine- 4-carboxamide;2-(1H-lmidazol-1-yl)-N-(1-(2-methoxyethyl)piperidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(piperidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(1-(3,3,3-trifluoropropyl)piperidin-4-yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,4r)-4-((2-methoxyethyl)amino)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,4r)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,4r)-4-methoxycyclohexyl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-cyclohexyl-2-(1H-lmidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(1-methylpiperidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(tetrahydro-2H-pyran-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(4-(2-methoxyethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-(1-Acetylpiperidin-4-yl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,3r)-3-(2-methoxyethoxy)cyclobutyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,3r)-3-methoxycyclobutyl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(1-(3,3,3-trifluoropropyl)pyrrolidin-3-yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(1 -(2, 2, 2-trifluoroethyl)pyrrolidin-3-yl)-5H-pyrrolo[3,2-d] pyrimidine- 4-carboxamide;2-(1H-lmidazol-1-yl)-N-((1s,4s)-4-(2-methoxyethoxy)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-methyl-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-(methylamino)ethoxy)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(2-(Dimethylamino)ethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(pyrrolidin-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(1 -methyl pyrrol idin-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(1-(methylsulfonyl)piperidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(1-(oxetan-3-yl)piperidin-4-yl)- 5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-Cyclobutyl-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-(Cyclohexylmethyl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-Benzyl-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-(methylamino)-2-oxoethoxy)cyclohexyl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(pyridin-2-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-phenyl-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(pyridin-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(5-methoxypyridin-2-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(6-methoxypyridin-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(1H-pyrazol-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-(4-Chlorophenyl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-(3-Chlorophenyl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-(2-Chlorophenyl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-Cyclopentyl-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(tetrahydrofuran-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-Cycloheptyl-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-isopropyl-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(1-methyl-1H-pyrazol-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(1-methyl-1H-imidazol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-(3-Chloro-4-fluorophenyl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-((1r,4r)-4-(2-morpholinoethoxy)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(1 H-pyrazol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-lmidazol-1-yl)-N-(1-methyl-1 H-pyrazol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-lmidazol-1-yl)-N-(3-(2-methoxyethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-((2,2,2-trifluoroethyl)amino)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1s,4s)-4-((2, 2, 2-trifluoroethyl)amino)cyclohexyl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-((3,3,3-trifluoropropyl)amino)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(cyanomethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine- 4-carboxamide;N-((1r,4r)-4-((2,2-difluoroethyl)amino)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-((1s,4s)-4-((2,2-difluoroethyl)amino)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-(4,4-difluorocyclohexyl)-5-(1 H-imidazol-1 -yl )- 1 H-pyrazolo[3,4-c]pyridine-7- carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-6-methyl-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(methyl(3,3,3-trifluoropropyl)amino)cyclohexyl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1s, 4s)-4-(methyl(3, 3, 3-trifluoropropyl)amino)cyclohexyl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(methyl(2,2,2-trifluoroethyl)amino)cyclohexyl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1s,4s)-4-(methyl(2, 2, 2-trifluoroethyl)amino)cyclohexyl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(acetamidomethyl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-((2,2,2-trifluoroethyl)amino)cyclohexyl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;5-(1 H-imidazol-1 -yl)-N-((1s,4s)-4-((2, 2, 2-trifl uoroethyl)amino)cyclohexyl)-1H- pyrazolo[3,4-c]pyridine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1s,4s)-4-((2, 2, 2-trifl uoroethyl)amino)cyclohexyl)-1H- pyrazolo[3,4-c]pyridine-7-carboxamide;N-(4,4-difluorocyclohexyl)-2-(1 H-imidazol-1 -yl)-8-methyl-7H-purine-6-carboxamide;N-((1 R,4r)-4-((R)-2-hydroxy-3-methylbutoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-((1S,4r)-4-((S)-2-hydroxy-3-methylbutoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-((1 s,4s)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-hydroxy-4-(trifluoromethyl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(trifluoromethyl)cyclohexyl)thieno[3,2-d]pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1s, 4s)-4-(trifluoromethyl)cyclohexyl)thieno[3,2-d]pyrimidine-4- carboxamide;N-((3S,4R)-3-fluoropiperidin-4-yl)-2-(1 H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-((3R,4R)-3-fluoropiperidin-4-yl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 S,3S)-3-(2-methoxyethoxy)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 S,3R)-3-(2-methoxyethoxy)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 R,4r)-4-((R)-2-hydroxypropoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 R,4r)-4-((S)-2-hydroxypropoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-((1 R,4r)-4-((R)-2-hydroxy-2,3-dimethylbutoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-((1 R,4r)-4-((S)-2-hydroxy-2,3-dimethyl butoxy )cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 R,4r)-4-((R)-3,3,3-trifluoro-2-hydroxy-2- methylpropanamido)cyclohexyl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 R,4r)-4-((S)-3,3,3-trifluoro-2-hydroxy-2- methylpropanamido)cyclohexyl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxy-4-methylcyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide ;2-(1 H-imidazol-1 -yl)-N-((1s, 4s)-4-methoxy-4-methylcyclohexyl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-(5-(2-(dimethylamino)ethoxy)pyridin-2-yl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-(4-cyanophenyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-(3-fluoro-4-(2-methoxyethoxy)phenyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(1-(methoxymethyl)-1H-pyrazol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine- 4-carboxamide;N-((1 r,4r)-4-(2-(2-(dimethylamino)ethoxy)ethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-(5-chloropyridin-2-yl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1H-imidazol-1-yl)-N-(4-methyltetrahydro-2H-pyran-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)thieno[3,2-d]pyrimidine-4- carboxamide;N-(6-chloropyridin-3-yl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(pyridin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-((1r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-(2-chloropyridin-4-yl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-(5-chloropyridin-3-yl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-(4-chloropyridin-2-yl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(1-(2-morpholinoacetyl)piperidin-4-yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-(6-chloropyridin-2-yl)-2-(1H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(6-(2-morpholinoethoxy)pyridin-3-yl)-5H-pyrrolo[3,2-d]pyrimidine- 4-carboxamide;N-((1r,4r)-4-(2-(dimethylamino)-2-oxoethoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(trifluoromethyl)cyclohexyl)-7H-purine-6-carboxamide;N-((1r,4r)-4-cyanocyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-(4,4-difluorocyclohexyl)-2-(1 H-imidazol-1 -yl)thieno[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(pyrimidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-(6-(2-(dimethylamino)ethoxy)pyridin-3-yl)-2-(1 H-imidazol-1 -yl)thieno[3, 2-d]pyrimidine- 4-carboxamide;N-(4,4-difluorocyclohexyl)-2-(1 H-imidazol-1 -yl)-7H-purine-6-carboxamide;2-(1 H-imidazol-1 -yl)-N-(pyrimidin-5-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(6-(4-methylpiperazin-1 -yl)pyridin-3-yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-morpholinocyclohexyl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-(5-chloro-6-(2-morpholinoethoxy)pyridin-3-yl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-(2-(4,4-difluorocyclohexyl)ethyl)-2-(1 H-imidazol-1-yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-(6-(4-morpholinopiperidin-1-yl)pyridin-3-yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-(4,4-difluorocyclohexyl)-5-(1 H-imidazol-1 -yl )- 1 H-pyrazolo[4,3-d]pyrimidine-7- carboxamide;5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(trifluoromethyl)cyclohexyl)-1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1s,4s)-4-(trifluoromethyl)cyclohexyl)-1 H-pyrazolo[4, 3- d]pyrimidine-7-carboxamide;2-(1 H-imidazol-1 -yl)-N-(isoxazol-3-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(2-(2-methoxyethyl)-1 ,2, 3, 4-tetrahydroisoquinolin-7-yl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(1-phenylcyclopropyl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-(2-(2-methoxyethoxy)pyrimidin-5-yl)-5H-pyrrolo[3,2-d] pyrimidine- 4-carboxamide;N-(((1 r,4r)-4-cyanocyclohexyl)methyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine- 4-carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(trifluoromethoxy)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1r,4r)-4-fluorocyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1H-imidazol-1-yl)-N-((1s,4s)-4-morpholinocyclohexyl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(methylcarbamoyl)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(trifluoromethyl)cyclohexyl)-1 H-pyrazolo[3,4-c]pyridine- 7-carboxamide;N-(2-acetyl-2-azabicyclo[2.2.1]heptan-5-yl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-(4,4-difluorocyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-((1r,4r)-4-(hydroxymethyl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine- 4-carboxamide;N-((1 s,4s)-4-hydroxy-4-methylcyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;N-((1r,4r)-4-hydroxycyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;N-((1r,4r)-4-(1 ,1-dioxidoisothiazolidin-2-yl)cyclohexyl)-2-(1H-imidazol-1-yl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(2-(2-methoxyethyl)-1 ,2, 3, 4-tetrahydroisoquinolin-6-yl)-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-((3,3-difluoropropyl)amino)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methoxycyclohexyl)-1 H-pyrazolo[4,3-d]pyrimidine-7- carboxamide;N-((1r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-6-methyl-5H- pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(cyanomethyl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine- 4-carboxamide;N-((1 s,4s)-4-hydroxycyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2-d]pyrimidine-4- carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxypropan-2-yl)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1s, 4s)-4-((3, 3, 3-trifluoropropyl)amino)cyclohexyl )-1H- pyrazolo[3,4-c]pyridine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-((3,3,3-trifluoropropyl)amino)cyclohexyl)-1 H- pyrazolo[3,4-c]pyridine-7-carboxamide;N-(6-(3-(dimethylamino)prop-1-yn-1-yl)pyridin-3-yl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3, 2- d]pyrimidine-4-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-((2,2,2-trifluoroethyl)amino)cyclohexyl)-1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;N-((1 S,4r)-4-((S)-1-hydroxyethyl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1 R,4r)-4-((R)-1-hydroxyethyl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1 r,4r)-4-((2,2-difluoropropyl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1s,4s)-4-((2,2-difluoropropyl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1H-pyrazolo[3, 4- c] pyrid i ne-7 -carboxa m ide;N-((1 r,4r)-4-((2,2-difluoroethyl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-2-methyl-2H- pyrazolo[3,4-c]pyridine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-1 -methyl-1 H- pyrazolo[3,4-c]pyridine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)thieno[2,3-c]pyridine-7- carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-(methylamino)-2-oxoethyl)cyclohexyl)-1 H- pyrazolo [3 c] pyrid i ne-7-carboxa m ide;N-((1 r,4r)-4-(2-hydroxyethyl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(2-(dimethylamino)-2-oxoethoxy)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H- pyrazolo[4,3-d]pyrimidine-7-carboxamide;N-((1 r,4r)-4-(2-(dimethylamino)-2-oxoethoxy)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H- pyrazolo[3,4-c]pyridine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-(6-(2-(pyrrolidin-1 -yl)ethoxy)pyridin-3-yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1 r,4r)-4-(3,3-difluoroazetidin-1 -yl)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-(4-cyanophenyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4-c]pyridine-7-carboxamide;N-((1 r,4r)-4-(2,2-difluoroethylamino)cyclohexyl)-5-(1 H-imidazol-1 -yl )- 1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;N-((1 S,4r)-4-((S)-2-hydroxypropoxy)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1 R,4r)-4-((R)-2-hydroxypropoxy)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1 r,4r)-4-(acetamidomethyl)cyclohexyl)-5-(1 H-imidazol-1 -yl )-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)-2-(1 H-imidazol-1 -yl)thieno[3, 2- d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl)-N-(isoindolin-5-yl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(4-cyanophenoxy)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(methylsulfonyl)cyclohexyl)-5H-pyrrolo[3,2-d]pyrimidine- 4-carboxamide;N-((1 r,4r)-4-(cyanomethoxy)cyclohexyl)-5-(1 H-imidazol-1 -yl )- 1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;N-((1 r,4r)-4-(cyanomethoxy)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4-c]pyridine- 7-carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(oxetan-3-ylamino)cyclohexyl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(methylcarbamoyl)cyclohexyl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(methyl(2,2,2-trifluoroethyl)amino)cyclohexyl)-1 H- pyrazolo[3,4-c]pyridine-7-carboxamide;N-((1 r,4r)-4-(cyanomethyl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4-c]pyridine-7- carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(2,2,2-trifluoroethylamino)cyclohexyl)thieno[3,2- d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(2,2-difluoroethylamino)cyclohexyl)-2-(1 H-imidazol-1 -yl)thieno[3,2- d]pyrimidine-4-carboxamide;2-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-((3,3,3-trifluoropropyl)amino)cyclohexyl)thieno[3,2- d]pyrimidine-4-carboxamide;N-(6-(2-(dimethylamino)ethoxy)pyridin-3-yl)-5-(1 H-imidazol-1 -yl )-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;5-(1 H-imidazol-1 -yl)-N-(6-(piperazin-1 -yl )pyrid i n-3-yl )- 1 H-pyrazolo[3,4-c]pyridine-7- carboxamide;N-((1 r,4r)-4-(hydroxymethyl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4-c]pyridine- 7-carboxamide;N-((1 s,4s)-4-hydroxy-4-methylcyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1 r,4r)-4-(3,3-difluoroazetidin-1 -yl)cyclohexyl)-5-(1 H-imidazol-1 -yl )-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1 r,4r)-4-(1 -hydroxycyclopropyl)cyclohexyl)-5-(1 H-imidazol-1 -yl )-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;5-(1 H-imidazol-1 -yl)-N-(6-(trifluoromethyl)pyridin-3-yl)-1 H-pyrazolo[3,4-c]pyridine-7- carboxamide;N-(6-(2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethoxy)pyridin-3-yl)-5-(1 H-imidazol-1 -yl)-1 H- pyrazolo[3,4-c]pyridine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(oxetan-3-ylamino)cyclohexyl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1 r,4r)-4-((2,2-difluoropropyl)amino)cyclohexyl)-2-(1 H-imidazol-1 -yl)-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;5-(1 H-imidazol-1 -yl )- N-(isoi ndol i n-5-yl )- 1 H-pyrazolo[3,4-c]pyridine-7-carboxamide ;N-(2-acetylisoindolin-5-yl)-5-(1 H-imidazol-1-yl)-1 H-pyrazolo[3,4-c]pyridine-7- carboxamide;N-((1 r,4r)-4-(1 -hydroxycyclopropyl)cyclohexyl)-5-(1 H-imidazol-1 -yl )-1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1s,4s)-4-methyl-4-((2, 2, 2-trifl uoroethyl)amino)cyclohexyl )-1H- pyrazolo[3,4-c]pyridine-7-carboxamide;5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-methyl-4-((2,2,2-trifluoroethyl)amino)cyclohexyl)-1 H- pyrazolo[3,4-c]pyridine-7-carboxamide;5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(3-(trifluoromethyl)azetidin-1 -yl)cyclohexyl)-1 H- pyrazolo[4,3-d]pyrimidine-7-carboxamide;5-(1 H-imidazol-1 -yl )- N-((1 r,4r)-4-(methylcarbamoyl)cyclohexyl)-1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;N-((1 r,4r)-4-(acetamidomethyl)cyclohexyl)-5-(1 H-imidazol-1 -yl )-1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;N-((1 r,4r)-4-((2,2-difluoropropyl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl )-1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;N-(3,3-difluoropropyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4-c]pyridine-7-carboxamide;N-((1 r,4r)-4-((2,2-difluoropropyl)amino)cyclohexyl)-2-(1 H-imidazol-1 -yl)thieno[3,2- d]pyrimidine-4-carboxamide;5-(1H-imidazol-1-yl)-N-((1s,4s)-4-methyl-4-((2,2,2-trifluoroethyl)amino)cyclohexyl)-1H- pyrazolo [3 c] pyrid i ne-7-carboxa m ide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(methyl(2,2,2-trifluoroethyl)amino)cyclohexyl)-1 H- pyrazolo[4,3-d]pyrimidine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(3,3,3-trifluoropropoxy)cyclohexyl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(((2,2,2-trifluoroethyl)amino)methyl)cyclohexyl)-1 H- pyrazolo[3,4-c]pyridine-7-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1s,4s)-4-(2, 2, 2-trifluoroethoxy)cyclohexyl)-1H-pyrazolo[3, 4- c] pyrid i ne-7 -carboxa m ide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2,2,2-trifluoroethoxy)cyclohexyl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1r,4r)-4-((1,1-difluoro-2-methylpropan-2-yl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl)- 1H-pyrazolo[3,4-c]pyridine-7-carboxamide;N-((1s,4s)-4-((1,1-difluoro-2-methylpropan-2-yl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl)- 1H-pyrazolo[3,4-c]pyridine-7-carboxamide;N-((1 r,4r)-4-(3,3-difluoroazetidin-1 -yl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;N-((1s,4s)-4-(3-fluoro-3-methylazetidin-1-yl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H- pyrazolo[4,3-d]pyrimidine-7-carboxamide;N-((1 r,4r)-4-(3-fluoro-3-methylazetidin-1 -yl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H- pyrazolo[4,3-d]pyrimidine-7-carboxamide;N-((1 r,4r)-4-(3-cyano-3-methylazetidin-1-yl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H- pyrazolo[3,4-c]pyridine-7-carboxamide;N-((1s,4s)-4-(3-cyano-3-methylazetidin-1-yl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1H- pyrazolo[3,4-c]pyridine-7-carboxamide;N-((1s,4s)-4-(3-cyano-3-methylazetidin-1-yl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1H- pyrazolo[3,4-c]pyridine-7-carboxamide;N-((1r,4r)-4-((2,2-difluoroethyl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl)thieno[2, 3- c] pyrid i ne-7 -carboxa m ide;N-((1 r,4r)-4-((2,2-difluoropropyl)amino)cyclohexyl)-5-(1 H-imidazol-1 -yl)thieno[2,3- c] pyrid i ne-7 -carboxa m ide;N-((1 r,4r)-4-(1 -hydroxycyclopropyl)cyclohexyl)-5-(1 H-imidazol-1 -yl)thieno[2,3-c]pyridine- 7-carboxamide;N-((1 R,4r)-4-((R)-1-hydroxyethyl)cyclohexyl)-5-(1 H-imidazol-1 -yl)thieno[2, 3-c]pyridine-7- carboxamide;N-((1S,4r)-4-((S)-1-hydroxyethyl)cyclohexyl)-5-(1 H-imidazol-1 -yl)thieno[2, 3-c]pyridine-7- carboxamide;N-((1 r,3r)-3-(2-hydroxypropan-2-yl)cyclobutyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[4,3- d]pyrimidine-7-carboxamide;N-((1 r,3r)-3-(2-hydroxypropan-2-yl)cyclobutyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;N-((1 R,4r)-4-((R)-1-hydroxyethyl)cyclohexyl)-2-(1 H-imidazol-1 -yl)thieno[3, 2-d]pyrimidine- 4-carboxamide;N-((1S,4r)-4-((S)-1-hydroxyethyl)cyclohexyl)-2-(1 H-imidazol-1 -yl)thieno[3, 2-d]pyrimidine- 4-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)-7-methyl-5H-pyrrolo[3,2- d]pyrimidine-4-carboxamide;N-((1 r,4r)-4-(3-cyanoazetidin-1-yl)cyclohexyl)-5-(1 H-imidazol-1 -yl)-1 H-pyrazolo[3,4- c] pyrid i ne-7 -carboxa m ide;5-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-((2,2,2-trifluoroethyl)amino)cyclohexyl)thieno[2,3- c] pyrid i ne-7 -carboxa m ide;5-(1 H)-imidazol-1 -yl)-N-((1 r,4r)-4-(((2,2,2-trifluoroethyl)amino)methyl)cyclohexyl)-1 H- pyrazolo[4,3-d]pyrimidine-7-carboxamide;2-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-((1 , 1 ,1 -trifluoro-2-methylpropan-2-yl)amino)cyclohexyl)- 5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;N-((1r,4r)-4-((1,1-difluoro-2-methylpropan-2-yl)amino)cyclohexyl)-2-(1 H-imidazol-1 -yl)- 5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide;5-(1 H-imidazol-1 -yl)-N-((1s,4s)-4-methyl-4-((2, 2, 2-trifl uoroethyl)amino)cyclohexyl )-1H- pyrazolo[4,3-d]pyrimidine-7-carboxamide;-(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-methyl-4-((2,2,2-trifluoroethyl)amino)cyclohexyl)-1 H- pyrazolo[4,3-d]pyrimidine-7-carboxamide; -(1 H-imidazol-1 -yl)-N-((1 r,4r)-4-((1 , 1 ,1 -trifluoro-2-methylpropan-2-yl)amino)cyclohexyl)- 1H-pyrazolo[4,3-d]pyrimidine-7-carboxamide; -(1 H-imidazol-1 -yl)-N-((1s,4s)-4-((1 , 1,1 -trifl uoro-2-methylpropan-2-yl)amino)cyclohexyl)-1H-pyrazolo[4,3-d]pyrimidine-7-carboxamide; -(1 H-imidazol-1 -yl)-4-(((1r, 4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-1-methylquinolin-2(1 H)-one; -1 H-imidazol-1 -yl)-1 -methyl-4-(((1r, 4r)-4(oxetan-3-ylaminocyclohexyl)amino)quinolin- 2(1 H)-one; -(1 H-imidazol-1 -yl)-4-(((1r,4r)-4-2-methoxyethoxy)cyclohexyl)amino)-1-methyl-1, 5- naphthyridin-2(1 H)-one; -(((1r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)amino)-6-(1 H-imidazol-1 -yl)-1-methyl-1 ,5- naphthyridin-2(1 H)-one; -(((1r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)amino)-6-(1 H-imidazol-1 -yl)-1-methyl-1, 7- naphthyridin-2(1 H)-one; -(1 H-imidazol-1 -yl)-4-(((1r,4r)-4-(2-methoxyethoxylcyclohexyl)amino)-1-methyl-1, 7- naphthyridin-2(1 H)-one; -(1 H-imidazol-1 -yl )-8-(((1 r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-5- methylpyrido[3,2-d]pyrimidin-6(5H)-one; -(((1r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)amino)-2-(1 H-imidazol-1 -yl)-5- methylpyrido[3,2-d]pyrimidin-6(5H)-one; -(1 H-imidazol-1 -yl)-5-methyl-8-(4-trifluoromethyl)phenyl)aminopyrido[3,2-d]pyrimidin- 6(5H)-one; -(1 H-imidazol-1 -yl)-5-methyl-8-6-(2-morpholinoethoxy)pyridin-3-yl)amino)pyrido[3, 2- d] pyri m id i n-6(5H )-o ne ; -(1 H-imidazol-1 -yl)-1-methyl-4-((1r,4r)-4-(2, 2,2- trifluoroethyl)amino)cyclohexyl)amino)quinolin-2(1 H)one; -(((1r,4r)-4-(2-hydroxypropan-2-yl)cyclohexyl)amino)-6-(1 H-imidazol-1 -yl)-1 - methylquinolin-2(1 H)-one;-(1 H-imidazol-1 -yl)-1-methyl-4-(1-(methylsulfonyl)piperidin-4-yl)amino)quinolin-2(1H)- one; -(((1r,4r)-4-(6-(1 H-imidazol-1 -yl)-1-methyl-2-oxo-1,2-dihydroquinolin-4- yl )am i nocyclo hexyl )oxy)-N , Nd i methylaceta m ide ; -(1 H-imidazol-1 -yl)-1-methyl-4-((6-(2, 2, 2-trifluoroethoxy)pyridin-3-yl)amino)quinolin- 2(1 H)-one; -(((1r,4r)-4-(2,2-difluoropropyl)amino)cyclohexyl)amino)-6-(1 H-imidazol-1 -yl)-1- methylquinolin-2(1 H)-one; -((-(2-(dimethylamino)ethoxy)pyridin-3-yl)amino)-6-(1H-imidazol-1-yl)-1 -methylquinolin- 2(1 H)-one; -(1H-imidazol-1-yl)-1-methyl-4-(((1r,4r)-4-(2(pyrrolidin-1- yl)ethoxy)cyclohexyl)amino)quinolin-2(1H)-one; -(((1 r,4r)-4-(2,2-difluoropropyl)aminocyclohexyl)amino)-2-(1 H-imidazol-1 -yl )-5- methylpyrido[3,2-d]pyrimidin-6(5H)-one; -(1S,4r)-4-((S)-1-hydroxyethyl)cyclohexyl)amino)-2-(1 H-imidazol-1 -yl)-5- methylpyrido[3,2-d]pyrimidin-6(5H)-one; -(((1r,4r)-4-((2-(1 H-imidazol-1 -yl )-5-methyl-6-oxo-5, 6-dihydropyrido[3, 2-d]pyrimidin-8- yl)amino)cyclohexyl)oxy)-N,N-dimethylacetamide; -((2-(1 H-imidazol-1 -yl)-5-methyl-6-oxo-5,6-dihydropyrido[3,2-d]pyrimidin-8- yl)amino)benzonitrile; -(1 H-imidazol-1 -yl)-5-methyl-8-(((1 r,4r)-4-(2,2,2- trifluoroethyl)amino)cyclohexyl)amino)pyrido[3,2-d]pyrimidin-6(5H)-one; -(1 H-imidazol-1 -yl )-8-(((1 r,4r)-4-methoxycyclohexyl)amino)-5-methylpyrido[3,2- d] pyri m id i n-6(5H )-o ne ; -1 H-imidazol-1 -yl)-5-methyl-8-6-(2-(pyrrolidin-1-yl)ethoxy)pyridin-3-yl)amino)pyrido[3, 2- d]pyrimidin-(5H)-one; -(4,4-difluorocyclohexyl)amino)-2-(1 H-imidazol-1 -yl)-5-methylpyrido[3,2-d]pyrimidin- 6(5H)-one; -(((1r,4r)-4-(1-hydroxycyclopropyl)cyclohexyl)amino)-2-(1 H-imidazol-1 -yl)-5- methylpyrido[3,2-d]pyrimidin-6(5H)-one;-(((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-5-methyl-2-(thiazol-5-yl)pyrido[3,2- d] pyri m id i n-6-(5 H )-o ne ; -Phenyl-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -(4-Chloro-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -[1-Pyridin-4-yl-meth-(Z)-ylidene]-3-m-tolyl-imidazolidine-2, 4-dione; -(4-Ethyl-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -(3-Chloro-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -(3,4-Dichloro-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;-Benzyl-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -(4-Methylsulfanyl-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;-Cyclohexyl-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -(3,4-Difluoro-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -{2,5-Dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-l-yl}-benzonitrile; -(4-Fluoro-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -(3-Acetyl-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -(4-Dimethylamino-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;-{2,5-Dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-l-yl}-benzoic acid; -[1-Pyridin-4-yl-meth-(Z)-ylidene]-3-(3-trifluoromethyl-phenyl)-imidazolidine-2, 4-dione;-(4-Methoxy-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -[1-Pyridin-4-yl-meth-(Z)-ylidene]-3-p-tolyl-imidazolidine-2, 4-dione; -(4-Bromo-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -lsopropyl-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -Hexyl-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -(4-Acetyl-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -(4-Butyl-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione; -(4-Methanesulfinyl-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;3-(4-Methanesulfonyl-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;3-{2,5-Dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-1-yl}-benzoic acid;3-[3-(Morpholine-4-carbonyl)-phenyl]-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine- 2, 4-dione;3-[4-(Morpholine-4-carbonyl)-phenyl]-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine- 2, 4-dione;5-[1-Pyridin-4-yl-meth-(Z)-ylidene]-3-(4-trifluoromethoxy-phenyl)-imidazolidine-2, 4-dione;5-[1-Pyridin-4-yl-meth-(2)-ylidene]-3-(4-trifluoromethyl-phenyl)-imidazolidine-2, 4-dione;(4-{2,5-Dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-1-yl}-phenyl)-acetic acid;3-(4-lodo-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;3-{2,5-Dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-1yl}-N-(2-morpholin-4-yl- ethyl)-benzamide;3-(4-tert-Butyl-phenyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;3-[2-(3,4-Diethoxy-phenyl)-ethyl]-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2,4- dione;5-[1-Pyridin-4-yl-meth-(Z)-ylidene]-3-(2-pyrrolidin-1-yl-ethyl)-imidazolidine-2, 4-dione;3-Adamantan-l-yl-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;3-Pyridin-3-yl-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;3-(4-Hydroxy-cyclohexyl)-5-[1-pyridin-4-yl-meth-(2)-ylidene]-imidazolidine-2, 4-dione;3-Propyl-5-[1-pyridin-4-yl-meth-(2)-ylidene]-imidazolidine-2, 4-dione;3-Sec-Butyl-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;{2,5-Dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-1-yl}-acetic acid ethyl ester;3-(3-Morpholin-4-yl-propyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;3-[4-((2R,6S)-2,6-Dimethyl-morpholine-4-carbonyl)-phenyl]-5-[1-pyridin-4-yl-meth-(Z)- ylidene]-imidazolidine-2, 4-dione;{2,5-Dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-1-yl}-acetic acid;3-[4-(4-Methyl-piperidine-1-carbonyl)-phenyl]-5-[1-pyridin-4-yl-meth-(Z)-ylidene]- imidazolidine-2, 4-dione;5-[1-Pyridin-4-yl-meth-(Z)-ylidene]-3-[4-(pyrrolidine-1-carbonyl)-phenyl]-imidazolidine- 2, 4-dione;N-Cyclopentyl-4-{2,5-dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-1-yl}- benzamide;N-Cyclopropyl-4-{2,5-dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-1-yl}- benzamide;N-Cyclohexyl-4-{2,5-dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-l-yl}- benzamide;3-(3-Hydroxy-2,2-dimethyl-propyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2,4- dione;3-(3,3-Difluoro-cyclobutyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;1-(4-{2,5-Dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-1-yl}-benzoyl)-piperidine-4-carboxylic acid ethyl ester;3-(1-Hydroxy-cyclohexylmethyl)-5-[1-pyridin-4-yl-meth-(2)-ylidene]-imidazolidine-2,4- dione;5-[1-Pyridin-4-yl-meth-(Z)-ylidene]-3-(tetrahydro-pyran-4-ylmethyl)-irnidazolidine-2,4- dione;3-(3-Hydroxy-3-methyl-butyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;3-(1-Hydroxy-cyclopentylmethyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2,4- dione;3-(1-Hydroxy-cyclobutylmethyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2,4- dione;5-[1-Pyridin-4-yl-meth-(Z)-ylidene]-3-(tetrahydro-furan-2-ylmethyl)-imidazolidine-2,4- dione;3-(2-Hydroxy-2-methyl-propyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2,4- dione;3-(trans-4-Hydroxy-cyclohexylmethyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2,4-dione;5-[1-Pyridin-4-yl-meth-(Z)-ylidene]-3-(2, 2, 2-trifluoro-ethyl)-imidazolidine-2, 4-dione;3-(1-Hydroxymethyl-cyclobutyl methyl )-5-[1-pyridin-4-yl-meth-(Z)-yl idene]-imidazolidine-2, 4-dione;3-(1-Hydroxymethyl-cyclopentylmethyl)-5-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidine-2, 4-dione;N-(2-{2,5-Dioxo-4-[1-pyridin-4-yl-meth-(Z)-ylidene]-imidazolidin-1-yl}-ethyl)-2,2,2- trifl uoro-aceta m ide ;Quercetin;Luteol in;Tyrphostin 8;Juglone;Apigenin;Shikonin;4-chloro-1H-pyrazolo[3,4-d]pyrimidine;(E)-5-amino-4-(2,3-dihydrobenzo[d]thiazol-2-yl)-1-((2,3,4-trihydroxybenzylidene)amino)-1 ,2-dihydro-3H-pyrrol-3-one;2-(1,4-dioxo-3,4-dihydrophthalazin-2(1H)-yl)-N-(pyridin-3-yl)acetamide;4-((E)-(((Z)-2-(isopropylimino)-4-(thiophen-2-yl)thiazol-3(2H)- yl)imino)methyl)benzene-1,2,3-triol;2,2'-bi(1 ,3-d ithiolyl idene);(E)-2-(3-bromo-4-hydroxy-5-methoxystyryl)-5-isobutylthieno[2,3-d]pyrimidin-4(3H)-one;(E)-3-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-(4-methylthiazol-2-yl)acrylonitrile;(Z)-5-(3-bromo-4-hydroxy-5-methoxybenzylidene)-2-thioxothiazolidin-4-one;(E)-1-(benzo[d]thiazol-2-yl)-3-(3-bromo-4-hydroxy-5-methoxyphenyl)prop-2-en-1-one;(E)-2-(benzo[d]thiazol-2-yl)-3-(3-bromo-4-hydroxy-5-methoxyphenyl)acrylonitrile;(E)-3-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-cyano-N-(2-fluorophenyl)acrylamide;(E)-N-benzyl-3-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-cyanoacrylamide;(E)-3-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-cyano-N-(2-ethoxyphenyl)acrylamide;(E)-2-(1H-benzo[d]imidazol-2-yl)-3-(3-bromo-4-hydroxy-5-methoxyphenyl)acrylonitrile;(E)-3-(3-bromo-4-hydroxy-5-methoxyphenyl)-1-(pyridin-3-yl)prop-2-en-1-one;4-((E)-(2-((E)-2-(1H-imidazol-2-yl)vinyl)-1H-imidazol-4-yl)diazenyl)-2-bromo-6- methoxyphenol;4-((E)-2-(2-((E)-(1H-imidazol-2-yl)diazenyl)-1H-imidazol-4-yl)vinyl)-2-bromo-6- methoxyphenol; a-Linolenic acid;Linolenic acid;Stearic acid;Elaidic acid;Arachidonic acid;Oleic acid;Palmitoleic acid;Tryptophan;Nicotinic acid;Quinolinic acid;Nicotinamide mononucleotide;Nicotinamide riboside; or a pharmaceutically acceptable salt thereof.

6. The method according to any of claims 1-5, wherein the method further comprises administration of a dipeptidyl peptidase-4 (DPP-4) inhibitor, a cyclic adenosine monophosphate (cAMP) activator, a protein kinase A (PKA), an exchange protein activated by cAMP (EPAC) activator, a Beta-adrenergic receptor (P-AR) agonist, a growth / differentiation factor 15 (GDF15) agonist, a cAMP responsive element binding (CREB) activator, a leptin sensitizer, an activin IIreceptor agonist, a monoacylglycerol acyltransferase 2 agonist (MGAT2), a G-protein coupled receptor 40 agonist (GPR40), or an epidermal growth factor receptor (EGFR) agonist.

7. The method according to any of claims 1-6, wherein the enteroendocrine-pancreatic hormone pathway modulator comprises a glucagon-like peptide-1 (GLP-1) receptor agonist, a glucose-dependent insulinotropic polypeptide (GIP) receptor agonist, a GIP receptor antagonist, a glucagon (GCG) receptor agonist, an amylin receptor agonist, a peptide YY (PYY) receptor agonist, an oxyntomodulin (OXYN) receptor agonist, an insulin receptor agonist, an insulin receptor antagonist, or a combination thereof.

8. The method according to any of claims 1-7, wherein the enteroendocrine-pancreatic hormone pathway modulator is semaglutide, exenatide, liraglutide, lixisenatide, tirzepatide, Noiiglutide, dulaglutide, albiglutide, oxyntomodulin (OXYN), glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), glucagon (GCG), Peptide YY (PYY), amylin, insulin, dapiglutide, efinopegdutide, exendin-4, beinaglutide, efpeglenatide, langlenatide, polyethylene glycol loxenatide, taspoglutide, ecnoglutide, utreglutide, gelpaglutide, apraglutide, maridebart, cafraglutide, pegapamodutide, mazdutide, survodutide, bamadutide, pemvidutide, cotadutide, NN9709, NN9423, Bl 456906, PF-07081532, retatrutide, glutazumab, cagrilintide, premlintide, CagriSema, OXM, NN9748 (NN9794), PYY 1875, NCC0165-1875, NCC0165-1562, Y014, Y242, Y3394, KBP-089, KBP-042, davalintide, AZD6234, AZD9550, ECC5004, ZP8396, orforglipron, danuglipron, lotiglipron, aleniglipron, AZD5004, DA-15864, ID110521156, MLX- 7005, RGT075, GS-4571, OWL833, HD-7671, CT-996, XW003, MEDI0382, AMG 133, ZP6590, HM15136, HM15211, DA1726, GX-G6, GZR18, HRS9531, BGMO504, PB718, RAY1225, VCT220, VK2735, SCO-094, CT-388, amycretin, Dacra QW II, DA-1726 , NNC0519-0130, CIN- 209, CIN-210, CIN-110, or any combination thereof.

9. The method according to any of claims 1-8, wherein the subject is an adult subject with a body mass index (BMI) of at least 25, e.g., a BMI in the range of 28-40.

10. The method according to any of claims 1-9, wherein the subject is a child or adolescent aged in the range of 2-19 years with a BMI of at least the 85thpercentile on the CDC growth charts.

11. The method according to any of claims 1-10, wherein the subject has received at least one therapy for obesity, overweight, or a weight-related condition, but failed to achieve an intended clinical outcome, wherein the intended clinical outcome is a reduction of body weight by at least 5% of the baseline body weight prior to the start of the at least one therapy.

12. The method according to any of claims 1-11, wherein the CD38 inhibitor and the enteroendocrine-pancreatic hormone pathway modulator are administered concurrently, simultaneously, or sequentially13. The method according to any of claims 1-12, wherein the CD38 inhibitor and enteroendocrine-pancreatic hormone pathway modulator are formulated as a single formulation, as part of a single molecular construct, or as separate formulations.

14. The method according to any of claims 1-13, wherein the subject has one or more of central adiposity, cardiovascular disease, kidney disease, fatty liver disease, sleep apnea, high blood pressure, high blood triglyceride levels, high blood cholesterol levels, low high-density lipoprotein (HDL) levels, and a hemoglobin A1c (HbA1c) level of 6% or greater.

15. The method according to any of claims 1-14, wherein each of the CD38 inhibitor and the enteroendocrine-pancreatic hormone pathway modulator is independently administered subcutaneously or intravenously.

16. The method according to any of claims 1-15, wherein the administration of the CD38 inhibitor and the enteroendocrine-pancreatic hormone pathway modulator to the subject reduces triglyceride, total cholesterol, low density lipoprotein (LDL) cholesterol, and / or non-fasted glucose levels relative to a baseline level as measured prior to the administration of the CD38 inhibitor and the enteroendocrine-pancreatic hormone pathway modulator to the subject; and wherein the administration to the subject improves the reduction of triglyceride, total cholesterol, LDL cholesterol, and / or non-fasted glucose levels relative to administration of the enteroendocrine-pancreatic hormone pathway modulator alone to the subject.

17. The method according to any of claims 1 -16, whereinthe administration of the CD38 inhibitor and the enteroendocrine-pancreatic hormone pathway modulator to the subject reduces fat mass, preserves lean body mass and / or muscle function, or improves insulin sensitivity and / or insulin secretion relative to a baseline level as measured prior to the administration of the CD38 inhibitor and the enteroendocrine-pancreatic hormone pathway modulator to the subject; and wherein the administration to the subject improves insulin sensitivity and / or insulin secretion relative to administration of the enteroendocrine-pancreatic hormone pathway modulator alone to the subject.

18. The method according to any of claims 1 -17, wherein the therapeutically effective amount of the CD38 inhibitor is in the range of 0.01 to 300 mg / kg per day, e.g., 0.01 to 100 mg / kg per day.

19. The method according to any of claims 1-18, wherein the therapeutically effective amount of the CD38 inhibitor is less than 1% of the clinically-established therapeutic amount.

20. The method according to any of claims 1-19, wherein the therapeutically effective amount of the enteroendocrine-pancreatic hormone pathway modulator is in the range of 0.01 to 300 mg / kg per day, e.g., in the range of 0.01 to 100 mg / kg per day.

21. The method according to any of claims 1-20, wherein the therapeutically effective amount of the enteroendocrine-pancreatic hormone pathway modulator is less than 1% of the clinically-established therapeutic amount.

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