Delayed release oral pharmaceutical composition

WO2026076057A1PCT designated stage Publication Date: 2026-04-09AIHOL CORP
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Filing Date
2025-10-01
Publication Date
2026-04-09

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Abstract

Disclosed herein are compositions and methods for the treatment of inflammatory bowel disease. According to some embodiments, the compositions and methods involve the use of a delayed-release capsule formulation containing a mesalamine layer, a hyaluronan layer, and at least one coating layer.
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Description

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[0029] IVS RSbOWZSR RSaQ`W^bW]\ ^`]dWRSR PSZ]e W\ Q]\\SQbW]\ eWbV bVS O^^S\RSR R`OeW\Ua WaW\bS\RSR Oa O RSaQ`W^bW]\ ]T bVS ^`SaS\b SfO[^ZSa O\R Wa \]b W\bS\RSR b] `S^`SaS\b bVS ]\ZgT]`[a W\ eVWQV bVS ^`SaS\b SfO[^ZS [Og PS Q]\ab`cQbSR ]` cbWZWhSR' IVS RSaQ`W^bW]\ aSba T]`bVbVS Tc\QbW]\a ]T bVS SfO[^ZS O\R bVS aS_cS\QS ]T abS^a T]` Q]\ab`cQbW\U O\R ]^S`ObW\U bVSSfO[^ZS' ?]eSdS`& bVS aO[S ]` S_cWdOZS\b Tc\QbW]\a O\R aS_cS\QSa [Og PS OQQ][^ZWaVSR PgRWTTS`S\b SfO[^ZSa'

[0030] =]` Q]\dS\WS\QS& QS`bOW\ bS`[a S[^Z]gSR W\ bVS a^SQWTWQObW]\& SfO[^ZSa O\R O^^S\RSRQZOW[a O`S Q]ZZSQbSR VS`S' J\ZSaa ]bVS`eWaS RSTW\SR VS`SW\& aQWS\bWTWQ O\R bSQV\WQOZbS`[W\]Z]UWSa S[^Z]gSR W\ bVS ^`SaS\b RWaQZ]ac`S aVOZZ VOdS bVS [SO\W\Ua bVOb O`S Q][[]\Zgc\RS`ab]]R O\R caSR Pg ]\S ]T ]`RW\O`g aYWZZ W\ bVS O`b' J\ZSaa ]bVS`eWaS `S_cW`SR Pg Q]\bSfb&Wb eWZZ PS c\RS`ab]]R bVOb aW\UcZO` bS`[a aVOZZ W\QZcRS ^Zc`OZ T]`[a ]T bVS aO[S O\R ^Zc`OZ bS`[aaVOZZ W\QZcRS bVS aW\UcZO`' H^SQWTWQOZZg& Oa caSR VS`SW\ O\R W\ bVS QZOW[a& bVS aW\UcZO` T]`[a jOkO\R jO\k W\QZcRS bVS ^Zc`OZ `STS`S\QS c\ZSaa bVS Q]\bSfb QZSO`Zg W\RWQObSa ]bVS`eWaS' 7Za]& OacaSR VS`SW\ O\R W\ bVS QZOW[a& bVS bS`[a jOb ZSOab ]\Sk O\R j]\S ]` []`Sk VOdS bVS aO[S[SO\W\U O\R W\QZcRS ]\S& be]& bV`SS& ]` []`S'

[0031] D]beWbVabO\RW\U bVOb bVS \c[S`WQOZ `O\USa O\R ^O`O[SbS`a aSbbW\U T]`bV bVS P`]ORaQ]^S ]T bVS W\dS\bW]\ O`S O^^`]fW[ObW]\a& bVS \c[S`WQOZ dOZcSa aSb T]`bV W\ bVS a^SQWTWQSfO[^ZSa O`S `S^]`bSR Oa ^`SQWaSZg Oa ^]aaWPZS' 7\g \c[S`WQOZ dOZcS& V]eSdS`& W\VS`S\bZgQ]\bOW\a QS`bOW\ S``]`a \SQSaaO`WZg `SacZbW\U T`][ bVS abO\RO`R RSdWObW]\ T]c\R W\ bVS `Sa^SQbWdSbSabW\U [SOac`S[S\ba' 7Za]& Oa caSR VS`SW\& bVS bS`[ jOP]cbk US\S`OZZg [SO\a eWbVW\ *)!&.!& *!& ]` )'.! ]T O UWdS\ dOZcS ]` `O\US' 7ZbS`\ObWdSZg& bVS bS`[ jOP]cbk [SO\a eWbVW\ O\OQQS^bOPZS abO\RO`R S``]` ]T bVS [SO\ eVS\ Q]\aWRS`SR Pg ]\S ]T ]`RW\O`g aYWZZ W\ bVS O`b'EbVS` bVO\ W\ bVS ]^S`ObW\U(e]`YW\U SfO[^ZSa& ]` c\ZSaa ]bVS`eWaS Sf^`SaaZg a^SQWTWSR& OZZ ]TbVS \c[S`WQOZ `O\USa& O[]c\ba& dOZcSa O\R ^S`QS\bOUSa acQV Oa bV]aS T]` _cO\bWbWSa ]T[ObS`WOZa& Rc`ObW]\a ]T bW[Sa& bS[^S`Obc`Sa& ]^S`ObW\U Q]\RWbW]\a& `ObW]a ]T O[]c\ba& O\R bVSZWYSa bVS`S]T RWaQZ]aSR VS`SW\ aV]cZR PS c\RS`ab]]R Oa []RWTWSR W\ OZZ W\abO\QSa Pg bVS bS`[jOP]cb'k 7QQ]`RW\UZg& c\ZSaa W\RWQObSR b] bVS Q]\b`O`g& bVS \c[S`WQOZ ^O`O[SbS`a aSb T]`bV W\bVS ^`SaS\b RWaQZ]ac`S O\R ObbOQVSR QZOW[a O`S O^^`]fW[ObW]\a bVOb QO\ dO`g Oa RSaW`SR' 7bbVS dS`g ZSOab& SOQV \c[S`WQOZ ^O`O[SbS` aV]cZR Ob ZSOab PS Q]\ab`cSR W\ ZWUVb ]T bVS \c[PS` ]T`S^]`bSR aWU\WTWQO\b RWUWba O\R Pg O^^ZgW\U ]`RW\O`g `]c\RW\U bSQV\W_cSa' GO\USa QO\ PSSf^`SaaSR VS`SW\ Oa T`][ ]\S S\R^]W\b b] O\]bVS` S\R^]W\b ]` PSbeSS\ be] S\R^]W\ba' 7ZZ`O\USa RWaQZ]aSR VS`SW\ O`S W\QZcaWdS ]T bVS S\R^]W\ba& c\ZSaa a^SQWTWSR ]bVS`eWaS'

[0032] IVS bS`[a jb`SOb[S\bk O\R jb`SObW\Uk Oa caSR VS`SW\ [Og `STS` b] O ^`SdS\bObWdS "S'U'&^`]^VgZOQbWQ#& Qc`ObWdS ]` ^OZZWObWdS [SOac`S' @\ ^O`bWQcZO`& bVS bS`[ jb`SObW\Uk Oa caSR VS`SW\`STS`a b] bVS O^^ZWQObW]\ ]` OR[W\Wab`ObW]\ ]T bVS ^`SaS\b RSZOgSR#`SZSOaS QO^acZS T]`[cZObW]\ab] O acPXSQb& eV] VOa O [SRWQOZ Q]\RWbW]\& O ag[^b][ Oaa]QWObSR eWbV bVS [SRWQOZ Q]\RWbW]\& ORWaSOaS ]` RWa]`RS` aSQ]\RO`g b] bVS [SRWQOZ Q]\RWbW]\& ]` O ^`SRWa^]aWbW]\ b]eO`R bVS [SRWQOZQ]\RWbW]\& eWbV bVS ^c`^]aS b] ^O`bWOZZg ]` Q][^ZSbSZg OZZSdWObS& O[SZW]`ObS& `SZWSdS& RSZOg ]\aSb]T& W\VWPWb ^`]U`SaaW]\ ]T& `SRcQS aSdS`Wbg ]T& O\R(]` `SRcQS W\QWRS\QS ]T ]\S ]` []`S ag[^b][a]` TSObc`Sa ]T aOWR ^O`bWQcZO` RWaSOaS& RWa]`RS`& O\R(]` Q]\RWbW]\ Oaa]QWObSR eWbV W\TZO[[Ob]`gP]eSZ RWaSOaS' I`SOb[S\b [Og PS OR[W\WabS`SR b] O acPXSQb eV] R]Sa \]b SfVWPWb aWU\a ]T ORWaSOaS& RWa]`RS`& O\R(]` Q]\RWbW]\& O\R(]` b] O acPXSQb eV] SfVWPWba ]\Zg SO`Zg aWU\a ]T ORWaSOaS& RWa]`RS` O\R(]` Q]\RWbW]\& T]` bVS ^c`^]aS ]T RSQ`SOaW\U bVS `WaY ]T RSdSZ]^W\U^ObV]Z]Ug Oaa]QWObSR eWbV bVS RWaSOaS& RWa]`RS` O\R(]` Q]\RWbW]\'

[0033] IVS bS`[a jacPXSQbk O\R j^ObWS\bk O`S caSR W\bS`QVO\USOPZg VS`SW\ O\R O`S W\bS\RSR b][SO\ O\ O\W[OZ W\QZcRW\U bVS Vc[O\ a^SQWSa bVOb Wa b`SObOPZS Pg bVS RSZOgSR#`SZSOaS QO^acZST]`[cZObW]\a O\R(]` [SbV]R ]T bVS ^`SaS\b W\dS\bW]\' IVS bS`[ jacPXSQbk ]` j^ObWS\bkW\bS\RSR b] `STS` b] P]bV bVS [OZS O\R TS[OZS US\RS` c\ZSaa ]\S US\RS` Wa a^SQWTWQOZZgW\RWQObSR'

[0034] IVS bS`[a jO^^ZWQObW]\k O\R jOR[W\Wab`ObW]\k O`S caSR W\bS`QVO\USOPZg VS`SW\ b] [SO\bVS O^^ZWQObW]\ ]T bVS RSZOgSR#`SZSOaS QO^acZS T]`[cZObW]\a ]T bVS ^`SaS\b W\dS\bW]\ b] OacPXSQb W\ \SSR ]T O b`SOb[S\b bVS`S]T'

[0035] IVS bS`[ jSTTSQbWdS O[]c\bk Oa caSR VS`SW\ `STS`a b] bVS _cO\bWbg ]T bVS ^`SaS\bRSZOgSR#`SZSOaS QO^acZS T]`[cZObW]\ bVOb Wa acTTWQWS\b b] gWSZR O RSaW`SR bVS`O^ScbWQ `Sa^]\aS'7\ STTSQbWdS O[]c\b ]T O\ OUS\b Wa \]b `S_cW`SR b] Qc`S O RWaSOaS ]` Q]\RWbW]\ Pcb eWZZ ^`]dWRS Ob`SOb[S\b T]` O RWaSOaS ]` Q]\RWbW]\ acQV bVOb bVS ]\aSb ]T bVS RWaSOaS ]` Q]\RWbW]\ Wa RSZOgSR&VW\RS`SR ]` ^`SdS\bSR& ]` bVS RWaSOaS ]` Q]\RWbW]\ ag[^b][a O`S O[SZW]`ObSR' IVS STTSQbWdSO[]c\b [Og PS RWdWRSR W\b] ]\S& be]& ]` []`S R]aSa W\ O acWbOPZS T]`[ b] PS OR[W\WabS`SR Ob]\S& be] ]` []`S bW[Sa bV`]cUV]cb O RSaWU\ObSR bW[S ^S`W]R' IVS a^SQWTWQ STTSQbWdS ]`acTTWQWS\b O[]c\b eWZZ dO`g eWbV acQV TOQb]`a Oa ^O`bWQcZO` Q]\RWbW]\ PSW\U b`SObSR& bVS ^VgaWQOZQ]\RWbW]\ ]T bVS ^ObWS\b "S'U'& bVS ^ObWS\bia P]Rg [Oaa& OUS& ]` US\RS`#& bVS bg^S ]T [O[[OZ ]`O\W[OZ PSW\U b`SObSR& bVS Rc`ObW]\ ]T bVS b`SOb[S\b& bVS \Obc`S ]T Q]\Qc``S\b bVS`O^g "WT O\g#&O\R bVS a^SQWTWQ T]`[cZObW]\a S[^Z]gSR O\R bVS ab`cQbc`S ]T bVS bVS`O^ScbWQ OUS\b ]` WbaRS`WdObWdSa' <TTSQbWdS O[]c\b [Og PS Sf^`SaaSR& T]` SfO[^ZS& Oa bVS b]bOZ [Oaa ]T bVSVgOZc`]\O\#R`cU Q]\XcUObS "]` bVS S_cWdOZS\b O[c\b ]T bVS R`cU#& S'U'& W\ U`O[a& [WZZWU`O[a ]`[WQ`]U`O[a& ]` O\ STTSQbWdS Q]\QS\b`ObW]\ ]T bVS VgOZc`]\O\#R`cU Q]\XcUObS W\ bVS TW\OZT]`[cZObW]\& S'U'& Oa [WZZWU`O[a ^S` [WZZWZWbS` "[U([B#'

[0036] IVS ^V`OaS j^VO`[OQScbWQOZZg OQQS^bOPZS SfQW^WS\bk Oa caSR VS`SW\ [SO\a O^VO`[OQScbWQOZZg OQQS^bOPZS [ObS`WOZ& Q][^]aWbW]\ ]` dSVWQZS& acQV Oa O ZW_cWR& RWZcS\b& QO``WS`&a]ZdS\b& W\d]ZdSR W\ QO``gW\U ]` b`O\a^]`bW\U bVS acPXSQb OUS\ba T`][ ]\S ]`UO\ ]` ^]`bW]\ ]T bVSP]Rg& b] O\]bVS` ]`UO\ ]` ^]`bW]\ ]T bVS P]Rg' <OQV SfQW^WS\b [cab PS jOQQS^bOPZSk W\ bVSaS\aS ]T PSW\U Q][^ObWPZS eWbV bVS ]bVS` W\U`SRWS\ba ]T bVS T]`[cZObW]\' IVS ^VO`[OQScbWQOZT]`[cZObW]\ Q]\bOW\a bVS VgOZc`]\O\#R`cU Q]\XcUObS ]T bVS W\dS\bW]\ W\ Q][PW\ObW]\ eWbV ]\S]` []`S ^VO`[OQScbWQOZZg OQQS^bOPZS W\U`SRWS\ba' F`STS`OPZg& bVS SfQW^WS\b QO\ PS W\ bVS T]`[]T O ZW_cWR RWZcS\b' IVSaS ^VO`[OQScbWQOZ ^`S^O`ObW]\a O`S O Tc`bVS` ]PXSQb ]T bVS W\dS\bW]\'JacOZZg& bVS O[]c\b ]T OQbWdS acPabO\QS Wa PSbeSS\ )'*#2.! Pg eSWUVb ]T bVS ^`S^O`ObW]\&^`STS`OPZg PSbeSS\ )'+#+)! Pg eSWUVb W\ ^`S^O`ObW]\a T]` ^O`S\bS`OZ caS ]` T]` b]^WQOZOR[W\Wab`ObW]\' =]` bVS QZW\WQOZ caS ]T bVS [SbV]Ra ]T bVS ^`SaS\b W\dS\bW]\& bVS^VO`[OQScbWQOZ Q][^]aWbW]\ ]T bVS W\dS\bW]\ Wa T]`[cZObSR W\b] T]`[cZObW]\a acWbOPZS T]` bVSW\bS\RSR `]cbS ]T OR[W\Wab`ObW]\'

[0037] 7a caSR VS`SW\& bVS bS`[ jVgOZc`]\WQ OQWRk "?7# "OZa] QOZZSR VgOZc`]\ObS ]` VgOZc`]\O\#Wa O\ O\W]\WQ& \]\acZTObSR UZgQ]aO[W\]UZgQO\ Q][^]aSR ]T Ob ZSOab ]\S RWaOQQVO`WRS c\Wb&a^SQWTWQOZZg O ;#UZcQc`]\WQ OQWR O\R O\ D#OQSbgZ#;#UZcQ]aO[W\S "#->ZQJ7"*#,>ZQD7Q"*##' IVS[]ZSQcZO` ]T ?7 QO\ `O\US T`][ ,02 ;OZb]\a ";O# "O aW\UZS ?7 []\][S`# b] [WZZW]\a ]T ;OZb]\a'HOZba ]T VgOZc`]\WQ OQWR W\QZcRS a]RWc[ VgOZc`]\ObS& ^]bOaaWc[ VgOZc`]\ObS& O\R bVS ZWYS' IVSbS`[ j?7 RS`WdObWdSk `STS`a b] O\ ?7 VOdW\U O\g []RWTWQObW]\ ]\ bVS VgR`]fgZ& QO`P]fgZ& O[WRS&]` OQSbgZO[W\] U`]c^a ]T ]\S ]` []`S RWaOQQVO`WRS c\Wba ]T bVS ?7'

[0038] 7QQ]`RW\U b] bVS ^`SaS\b RWaQZ]ac`S& I[Of [SO\a jbW[S b] ^SOY Q]\QS\b`ObW]\&k eVWQV WabVS bW[S `S_cW`SR b] `SOQV bVS ^SOY ^ZOa[O Q]\QS\b`ObW]\ ]T O R`cU OTbS` ]`OZ OR[W\Wab`ObW]\"9[Of#4 b*(+ [SO\a jPW]Z]UWQOZ VOZT#bW[S&k eVWQV Wa bVS bW[S `S_cW`SR T]` bVS Q]\QS\b`ObW]\ ]T bVSR`cU b] `SOQV VOZT ]T Wba ]`WUW\OZ dOZcS4 eVS`SOa IZOU [SO\a jZOU bW[S&k eVWQV Wa bVS bW[S T`][OR[W\Wab`ObW]\ ]T O R`cU b] TW`ab _cO\bWTWOPZS Q]\QS\b`ObW]\' =c`bVS`[]`S& 7J9 [SO\a jO`SOc\RS` bVS Qc`dS&k eVWQV Wa bVS W\bSU`OZ ]T bVS Q]\QS\b`ObW]\#bW[S Qc`dS "OTbS` O aW\UZS R]aS ]` W\abSORg abObS#' @\ ^O`bWQcZO`& 7J9)#b Wa bVS O`SO c\RS` bVS Qc`dS T`][ bW[S hS`] b] bVS ZOab\]\#hS`] Q]\QS\b`ObW]\& QOZQcZObSR caW\U bVS ZW\SO` b`O^Sh]WROZ [SbV]R4 7J9`STI[Of Wa bVS O`SOc\RS` bVS Q]\QS\b`ObW]\#bW[S Qc`dS T`][ bW[S hS`] b] bVS bW[S ]T bVS [OfW[c[ Q]\QS\b`ObW]\]T bVS `STS`S\QS ^`]RcQb "Q]``Sa^]\RW\U b] bVS [SRWO\ I[Of ]T bVS GSTS`S\QS ^`]RcQb#&QOZQcZObSR caW\U bVS ZW\SO` b`O^Sh]WROZ [SbV]R4 O\R 7J9)#W\T Wa bVS O`SO c\RS` bVS Qc`dS T`][bW[S hS`] b] W\TW\Wbg "Sfb`O^]ZObSR#& QOZQcZObSR Oa 7J9)#b%9b(ASZ& eVS`S 9b Wa bVS ZOab ]PaS`dSR\]\#hS`] Q]\QS\b`ObW]\'

[0039] IVS ^`SaS\b RWaQZ]ac`S Wa POaSR& Ob ZSOab W\ ^O`b& ]\ bVS RWaQ]dS`g bVOb bVSRSZOgSR#`SZSOaS QO^acZS T]`[cZObW]\a RSaQ`WPSR VS`SW\ W[^`]dS [SaOZO[W\S PW]OdOWZOPWZWbg b] Oac`^`WaW\U O\R c\Sf^SQbSR SfbS\b' @\ ^O`bWQcZO`& bVSaS T]`[cZObW]\a W\QZcRS O VgOZc`]\O\ ZOgS`bVOb ^ZOga O Q`WbWQOZ `]ZS W\ []RcZObW\U bVS `SZSOaS ^`]TWZS O\R ^`]bSQbW\U [SaOZO[W\S Rc`W\Ub`O\aWb bV`]cUV bVS UOab`]W\bSabW\OZ ">@# b`OQb' IVS W\QZcaW]\ ]T VgOZc`]\O\ ]T RWTTS`S\b[]ZSQcZO` eSWUVba S\OPZSa Tc`bVS` TW\S#bc\W\U ]T bVS `SZSOaS ^`]TWZS' 7a O `SacZb& bVST]`[cZObW]\ RSZWdS`a VWUVS` O\R []`S acabOW\SR Q]\QS\b`ObW]\a ]T [SaOZO[W\S W\ bVSPZ]]Rab`SO[& Oa SdWRS\QSR Pg SZSdObSR 9[Of "^SOY ^ZOa[O Q]\QS\b`ObW]\# O\R 7J9 "O`SO c\RS`bVS Qc`dS# dOZcSa& W\RWQObW\U S\VO\QSR OPa]`^bW]\ O\R ^`]Z]\USR bVS`O^ScbWQ STTSQb'

[0040] 7RRWbW]\OZZg& bVS RSZOgSR#`SZSOaS [SQVO\Wa[& ac^^]`bSR Pg bVS [cZbW#ZOgS`SR ab`cQbc`S]T bVS ^O`bWQZSa& S\ac`Sa bVOb bVS [SaOZO[W\S Wa `SZSOaSR ^`W[O`WZg W\ bVS W\bSabW\OZ b`OQb& `ObVS`bVO\ W\ bVS ab][OQV' IVWa \]b ]\Zg [W\W[WhSa ^]bS\bWOZ aWRS STTSQba acQV Oa UOab`WQ W``WbObW]\ PcbOZa] [OfW[WhSa bVS Z]QOZ bVS`O^ScbWQ OQbW]\ ]T [SaOZO[W\S W\ W\TZO[SR O`SOa ]T bVS Q]Z]\&eVS`S Wb Wa []ab \SSRSR'

[0041] @\ ac[[O`g& bVS OPWZWbg ]T bVWa T]`[cZObW]\ b] `SZSOaS [SaOZO[W\S W\ O Q]\b`]ZZSR&acabOW\SR [O\\S` W[^`]dSa bVS b`SOb[S\b `SUW[S\ T]` ^ObWS\ba& ^O`bWQcZO`Zg bV]aS acTTS`W\UT`][ QV`]\WQ P]eSZ Q]\RWbW]\a ZWYS cZQS`ObWdS Q]ZWbWa' @b R]Sa a] Pg [OW\bOW\W\U STTSQbWdS R`cUQ]\QS\b`ObW]\a ]dS` O Z]\US` ^S`W]R& bVca S\VO\QW\U P]bV STTWQOQg O\R ^ObWS\b ]cbQ][Sa'

[0042] @\ dWSe ]T bVS T]`SU]W\U& bVS ^`SaS\b RWaQZ]ac`S OZa] ^`]^]aSa [SbV]Ra T]` ^`SdS\bW\UO\R(]` b`SObW\U W\TZO[[Ob]`g P]eSZ RWaSOaS Pg ]`OZZg OR[W\WabS`W\U bVS ^`SaS\bRSZOgSR#`SZSOaS QO^acZS T]`[cZObW]\a' 7Za] ^`]dWRSR VS`SW\ Wa bVS caS ]T aOWR RSZOgSR#`SZSOaSQO^acZS T]`[cZObW]\a W\ bVS ^`SdS\bW]\ O\R(]` b`SOb[S\b ]T W\TZO[[Ob]`g P]eSZ RWaSOaS& OaeSZZ Oa Wba caS W\ bVS [O\cTOQbc`S ]T O [SRWQO[S\b T]` aOWR b`SOb[S\b ^c`^]aS' IVS[SRWQO[S\b "W'S'& O ^VO`[OQScbWQOZ Q][^]aWbW]\# Wa& ]T Q]c`aS& O acPXSQb [ObbS` Q]dS`SR Pg bVSaQ]^S ]T bVS ^`SaS\b O^^ZWQObW]\'

[0043] @\ ]\S Oa^SQb& bVS ^`SaS\b RWaQZ]ac`S Wa RW`SQbSR b] O RSZOgSR#`SZSOaS QO^acZST]`[cZObW]\' IVS ^`SaS\b RSZOgSR#`SZSOaS QO^acZS T]`[cZObW]\ Wa ORdO\bOUS]ca W\ ^`]dWRW\U ORSaW`OPZS ^VO`[OQ]YW\SbWQ b] W[^`]dS bVS RSZWdS`g O\R PW]OdOWZOPWZWbg ]T OQbWdS W\U`SRWS\b'IVS ^`SaS\b RSZOgSR#`SZSOaS QO^acZS T]`[cZObW]\ Wa OZa] ORdO\bOUS]ca W\ VOdW\U O []`SQ][^OQb aWhS& bVS`SPg S\VO\QW\U ^ObWS\b Q][^ZWO\QS'

[0044] 7QQ]`RW\U b] QS`bOW\ S[P]RW[S\ba& bVS ^`SaS\b RSZOgSR#`SZSOaS QO^acZS T]`[cZObW]\W\QZcRSa O QO^acZS aVSZZ O\R O ^Zc`OZWbg ]T ^O`bWQZSa Q]\bOW\SR eWbVW\ bVS QO^acZS aVSZZ& eVS`SW\SOQV ^O`bWQZS W\QZcRSa3 "O# O\ W\S`b Q]`S& W\ O\ O[]c\b ]T OP]cb *)l+) eb! ]T bVS ^O`bWQZS4 "P# O[SaOZO[W\S ZOgS` O^^ZWSR b] bVS ac`TOQS ]T bVS W\S`b Q]`S& eVS`SW\ bVS [SaOZO[W\S ZOgS` Wa W\ O\O[]c\b ]T OP]cb -)l / . eb! ]T bVS ^O`bWQZS O\R Q][^`WaSa [SaOZO[W\S W\ O\ O[]c\b ]T OP]cb1)#22 eb! ]T bVS [SaOZO[W\S ZOgS`4 "Q# O VgOZc`]\O\ ZOgS` O^^ZWSR b] bVS ac`TOQS ]T bVS[SaOZO[W\S ZOgS`& eVS`SW\ bVS VgOZc`]\O\ ZOgS` Wa W\ O\ O[]c\b ]T OP]cb ,l*. eb! ]T bVS^O`bWQZS O\R W\QZcRSa VgOZc`]\WQ OQWR ]` O ^VO`[OQScbWQOZZg#OQQS^bOPZS aOZb bVS`S]T W\ O\O[]c\b ]T OP]cb .*#0) eb! ]T bVS VgOZc`]\O\ ZOgS`4 O\R "R# Ob ZSOab ]\S Q]ObW\U ZOgS` O^^ZWSRb] bVS ac`TOQS ]T bVS VgOZc`]\O\ ZOgS`& eVS`SW\ bVS Ob ZSOab ]\S Q]ObW\U ZOgS` Wa W\ O\ O[]c\b ]TOP]cb *.l,) eb! ]T bVS ^O`bWQZS'

[0045] 7a Q]cZR PS O^^`SQWObSR& bVS [OW\ W\U`SRWS\ba acQV Oa [SaOZO[W\S O\R VgOZc`]\WQ OQWR]` O ^VO`[OQScbWQOZZg#OQQS^bOPZS aOZb bVS`S]T QO\ PS T]`[cZObSR& b]USbVS` eWbV acWbOPZS^VO`[OQScbWQOZZg#OQQS^bOPZS SfQW^WS\ba& W\b] O [cZbW#ZOgS`SR QO^acZS T]`[cZObW]\ acWbOPZS T]`]`OZ OR[W\Wab`ObW]\'

[0046] IVS bS`[ jW\S`b Q]`Sk Oa caSR VS`SW\& `STS`a b] O ^VO`[OQScbWQOZZg OQQS^bOPZS W\S`bacPab`ObS eVWQV Wa `]cbW\SZg caSR W\ T]`[cZObW]\ O`b& bVOb W\QZcRSa& Pcb O`S \]b ZW[WbSR b]&^]eRS` ]` O [cZbW^O`bWQcZObS acQV Oa O U`O\cZS& O ^SZZSb& O PSOR& O a^VS`cZS& O PSORZSb& O[WZZWa^VS`S& O \O\]a^VS`S& O [WQ`]a^VS`S ]` O [W\WbOPZSb' 7QQ]`RW\U b] QS`bOW\ S[P]RW[S\ba]T bVS ^`SaS\b RWaQZ]ac`S& bVS W\S`b Q]`S W\QZcRSa O TWZZS`' <fO[^ZSa ]T TWZZS`a W\QZcRS Pcb O`S\]b ZW[WbSR b]& acUO`& [WQ`]Q`gabOZZW\S QSZZcZ]aS& dSUSbOPZS Uc[a& O\R eOfSa' @\ ]\SS[P]RW[S\b& bVS TWZZS` ]T bVS W\S`b Q]`S Wa [WQ`]Q`gabOZZW\S QSZZcZ]aS' IVS W\S`b Q]`Sa [Og PS^`S^O`SR eWbV bVS bSQV\W_cSa Y\]e\ b] O ^S`a]\ aYWZZSR W\ bVS O`b& acQV Oa& eSb U`O\cZObW]\& R`gU`O\cZObW]\& ]` Sfb`caW]\#a^VS`]\WhObW]\ O\R bVS ZWYS'

[0047] IVS W\S`b Q]`S QO\ PS Q][^`WaSR W\ bVS ^O`bWQZS& W\ O\ O[]c\b& T]` SfO[^ZS& `O\UW\U T`][OP]cb *) eb! b] +) eb!& ** eb! b] *2 eb!& *+ eb! b] *1 eb!& *, eb! b] *0 eb!& *- eb! b]* / eb!& *. eb! b] *1 eb!& ]` *0 eb! b] *2 eb!& POaSR ]\ bVS b]bOZ eSWUVb ]T bVS ^O`bWQZS'C]`S a^SQWTWQOZZg& bVS W\S`b Q]`S QO\ PS Q][^`WaSR W\ bVS ^O`bWQZS W\ O\ O[]c\b ]T OP]cb *)& *)'*&*)'+& *)',& *)'-& *)'.& *)' / & *)'0& *)'1& *)'2& **& **'*& **'+& **',& **'-& **'.& **' / & **'0& **'1&**'2& *+& *+'*& *+'+& *+',& *+'-& *+'.& *+' / & *+'0& *+'1& *+'2& *,& *,'*& *,'+& *,',& *,'-& *,'.& *,' / &*,'0& *,'1& *,'2& *-& *-'*& *-'+& *-',& *-'-& *-'.& *-' / & *-'0& *-'1& *-'2& *.& *.'*& *.'+& *.',& *.'-&*.'.& *.' / & *.'0& *.'1& *.'2& * / & * / '*& * / '+& * / ',& * / '-& * / '.& * / ' / & * / '0& * / '1& * / '2& *0& *0'*& *0'+&*0',& *0'-& *0'.& *0' / & *0'0& *0'1& *0'2& *1& *1'*& *1'+& *1',& *1'-& *1'.& *1' / & *1'0& *1'1& *1'2& *2&*2'*& *2'+& *2',& *2'-& *2'.& *2' / & *2'0& *2'1& *2'2& ]` +) eb!& POaSR ]\ bVS b]bOZ eSWUVb ]T bVS^O`bWQZS'

[0048] IVS [SaOZO[W\S ZOgS` QO\ PS Q][^`WaSR W\ bVS ^O`bWQZS& W\ O\ O[]c\b& T]` SfO[^ZS&`O\UW\U T`][ OP]cb -) eb! b] / . eb!& -. eb! b] / ) eb!& ]` .) eb! b] .. eb!& POaSR ]\ bVSb]bOZ eSWUVb ]T bVS ^O`bWQZS' C]`S a^SQWTWQOZZg& bVS [SaOZO[W\S ZOgS` QO\ PS Q][^`WaSR W\ bVS^O`bWQZS W\ O\ O[]c\b ]T OP]cb -)& -*& -+& -,& --& -.& - / & -0& -1& -2& .)& .*& .+& .,& .-& ..& . / & .0&.1& .2& / )& / *& / +& / ,& / -& ]` / . eb!& POaSR ]\ bVS b]bOZ eSWUVb ]T bVS ^O`bWQZS'

[0049] CSaOZO[W\S Wa bVS [OW\ W\U`SRWS\b ]T bVS [SaOZO[W\S ZOgS`' H^SQWTWQOZZg& [SaOZO[W\SQO\ PS Q][^`WaSR W\ bVS [SaOZO[W\S ZOgS`& W\ O\ O[]c\b& T]` SfO[^ZS& `O\UW\U T`][ OP]cb 1)eb! b] 22 eb!& 1+ eb! b] 20 eb!& 1- eb! b] 2. eb!& 1 / eb! b] 2, eb!& ]` 11 eb! b] 2* eb!&POaSR ]\ bVS b]bOZ eSWUVb ]T bVS [SaOZO[W\S ZOgS`' C]`S a^SQWTWQOZZg& [SaOZO[W\S QO\ PSQ][^`WaSR W\ bVS [SaOZO[W\S ZOgS` W\ O\ O[]c\b ]T 1)& 1*& 1+& 1,& 1-& 1.& 1 / & 10& 11& 12& 2)& 2*&2+& 2,& 2-& 2.& 2 / & 20& 21& ]` 22 eb!& POaSR ]\ bVS b]bOZ eSWUVb ]T bVS [SaOZO[W\S ZOgS`'

[0050] @\ ORRWbW]\ b] [SaOZO[W\S& bVS [SaOZO[W\S ZOgS` [Og Tc`bVS` W\QZcRS SfQW^WS\ba acQV OaOb ZSOab ]\S PW\RS`'

[0051] <fO[^ZSa ]T PW\RS` acWbOPZS T]` caS W\ bVS [SaOZO[W\S ZOgS` W\QZcRS Pcb O`S \]b ZW[WbSRb]& VgR`]fg^`]^gZ [SbVgZQSZZcZ]aS& VgR`]fg^`]^gZ QSZZcZ]aS O\R QO`P]fg[SbVgZ#QSZZcZ]aSa]RWc[& ^]dWR]\S& Q]^]ZgdWR]\S [OU\SaWc[ abSO`ObS& QOZQWc[ abSO`ObS& hW\Q abSO`ObS4 abSO`WQOQWR& VgR`]US\ObSR dSUSbOPZS ]WZ& VgR`]US\ObSR QOab]` ]WZ& UZgQS`gZ ^OZ[Wb]abSO`ObS& UZgQS`gZPSVS\ObS& ^]ZgSbVgZS\S UZgQ]Za& Q]`\ abO`QV& a]RWc[ abSO`gZ Tc[O`ObS& a]RWc[ PS\h]ObS&[W\S`OZ ]WZ& bOZQ& Q]ZZ]WROZ aWZWQ]\ RW]fWRS& [OU\SaWc[ b`WaWZWQObS& ^]eRS`SR QSZZcZ]aS& abO`QV&b`WPOaWQ QOZQWc[ ^V]a^VObS O\R bVS ZWYS ]` [Wfbc`Sa bVS`S]T' @\ ]\S S[P]RW[S\b& bVS PW\RS`caSR W\ bVS [SaOZO[W\S ZOgS` W\QZcRSa VgR`]fg^`]^gZ [SbVgZQSZZcZ]aS O\R bOZQ'

[0052] IVS PW\RS` QO\ PS Q][^`WaSR W\ bVS [SaOZO[W\S ZOgS`& W\ O\ O[]c\b& T]` SfO[^ZS&`O\UW\U T`][ OP]cb )'. eb! b] *. eb!& * eb! b] *-'. eb!& + eb! b] *- eb!& , eb! b] *,'.eb!& - eb! b] *, eb!& . eb! b] *+'. eb!& / eb! b] *+ eb!& ]` / '. eb! b] **'. eb!& POaSR ]\bVS b]bOZ eSWUVb ]T bVS [SaOZO[W\S ZOgS`' C]`S a^SQWTWQOZZg& bVS PW\RS` QO\ PS Q][^`WaSR W\bVS [SaOZO[W\S ZOgS` W\ O\ O[]c\b ]T )'.& )' / & )'0& )'1& )'2& *& *'*& *'+& *',& *'-& *'.& *' / & *'0& *'1&*'2& +& +'*& +'+& +',& +'-& +'.& +' / & +'0& +'1& +'2& ,& ,'*& ,'+& ,',& ,'-& ,'.& ,' / & ,'0& ,'1& ,'2& -& -'*&-'+& -',& -'-& -'.& -' / & -'0& -'1& -'2& .& .'*& .'+& .',& .'-& .'.& .' / & .'0& .'1& .'2& / & / '*& / '+& / ',& / '-& / '.& / ' / & / '0& / '1& / '2& 0& 0'*& 0'+& 0',& 0'-& 0'.& 0' / & 0'0& 0'1& 0'2& 1& 1'*& 1'+& 1',& 1'-& 1'.& 1' / & 1'0&1'1& 1'2& 2& 2'*& 2'+& 2',& 2'-& 2'.& 2' / & 2'0& 2'1& 2'2& *)& *)'*& *)'+& *)',& *)'-& *)'.& *)' / & *)'0&*)'1& *)'2& **& **'*& **'+& **',& **'-& **'.& **' / & **'0& **'1& **'2& *+& *+'*& *+'+& *+',& *+'-& *+'.&*+' / & *+'0& *+'1& *+'2& *,& *,'*& *,'+& *,',& *,'-& *,'.& *,' / & *,'0& *,'1& *,'2& *-& *-'*& *-'+& *-',&*-'-& *-'.& *-' / & *-'0& *-'1& *-'2& ]` *. eb!& POaSR ]\ bVS b]bOZ eSWUVb ]T bVS [SaOZO[W\S ZOgS`'

[0053] IVS VgOZc`]\O\ ZOgS` QO\ PS Q][^`WaSR W\ bVS ^O`bWQZS& W\ O\ O[]c\b& T]` SfO[^ZS&`O\UW\U T`][ OP]cb , eb! b] *. eb!& - eb! b] *- eb!& . eb! b] *, eb!& / eb! b] *+ eb!& 0eb! b] ** eb!& ]` 1 eb! b] *) eb!& POaSR ]\ bVS b]bOZ eSWUVb ]T bVS ^O`bWQZS' C]`Sa^SQWTWQOZZg& bVS VgOZc`]\O\ ZOgS` QO\ PS Q][^`WaSR W\ bVS ^O`bWQZS W\ O\ O[]c\b ]T OP]cb ,& ,'*&,'+& ,',& ,'-& ,'.& ,' / & ,'0& ,'1& ,'2& -& -'*& -'+& -',& -'-& -'.& -' / & -'0& -'1& -'2& .& .'*& .'+& .',& .'-&.'.& .' / & .'0& .'1& .'2& / & / '*& / '+& / ',& / '-& / '.& / ' / & / '0& / '1& / '2& 0& 0'*& 0'+& 0',& 0'-& 0'.& 0' / & 0'0&0'1& 0'2& 1& 1'*& 1'+& 1',& 1'-& 1'.& 1' / & 1'0& 1'1& 1'2& 2& 2'*& 2'+& 2',& 2'-& 2'.& 2' / & 2'0& 2'1& 2'2& *)&*)'*& *)'+& *)',& *)'-& *)'.& *)' / & *)'0& *)'1& *)'2& **& **'*& **'+& **',& **'-& **'.& **' / & **'0&**'1& **'2& *+& *+'*& *+'+& *+',& *+'-& *+'.& *+' / & *+'0& *+'1& *+'2& *,& *,'*& *,'+& *,',& *,'-& *,'.&*,' / & *,'0& *,'1& *,'2& *-& *-'*& *-'+& *-',& *-'-& *-'.& *-' / & *-'0& *-'1& *-'2& ]` *. eb!& POaSR]\ bVS b]bOZ eSWUVb ]T bVS ^O`bWQZS'

[0054] IVS [OW\ W\U`SRWS\b ]T bVS VgOZc`]\O\ ZOgS` Wa VgOZc`]\WQ OQWR ]` O^VO`[OQScbWQOZZg#OQQS^bOPZS aOZb bVS`S]T' H^SQWTWQOZZg& bVS VgOZc`]\WQ OQWR ]` bVS^VO`[OQScbWQOZZg#OQQS^bOPZS aOZb bVS`S]T QO\ PS Q][^`WaSR W\ bVS VgOZc`]\O\ ZOgS`& W\ O\O[]c\b& T]` SfO[^ZS& `O\UW\U T`][ OP]cb .* eb! b] 0) eb!& ., eb! b] / 1 eb!& .. eb! b] / / eb!& ]` .0 eb! b] / - eb!& POaSR ]\ bVS b]bOZ eSWUVb ]T bVS VgOZc`]\O\ ZOgS`' C]`Sa^SQWTWQOZZg& bVS VgOZc`]\WQ OQWR ]` bVS ^VO`[OQScbWQOZZg#OQQS^bOPZS aOZb bVS`S]T QO\ PSQ][^`WaSR W\ bVS VgOZc`]\O\ ZOgS` W\ O\ O[]c\b ]T .*& .+& .,& .-& ..& . / & .0& .1& .2& / )& / *& / +& / ,& / -& / .& / / & / 0& / 1& / 2& ]` 0) eb!& POaSR ]\ bVS b]bOZ eSWUVb ]T bVS [SaOZO[W\S ZOgS`'

[0055] 7QQ]`RW\U b] QS`bOW\ S[P]RW[S\ba ]T bVS ^`SaS\b RWaQZ]ac`S& bVS VgOZc`]\O\ ZOgS`W\QZcRSa P]bV VWUV#[]ZSQcZO` eSWUVb VgOZc`]\WQ OQWR "?CL?7# O\R Z]e#[]ZSQcZO` eSWUVbVgOZc`]\WQ OQWR "BCL?7# ]` O ^VO`[OQScbWQOZZg#OQQS^bOPZS aOZb bVS`S]T' @\ QS`bOW\S[P]RW[S\ba ]T bVS ^`SaS\b RWaQZ]ac`S& bVOb ?CL?7 VOa O dWaQ]aWbg OdS`OUS []ZSQcZO` eSWUVb"Cd# ]T +))) Y;O b] +.)) Y;O& O\R bVS BCL?7 VOa O\ Cd ]T ,)) Y;O b] .)) Y;O' C]`Sa^SQWTWQOZZg& bVS Cd ]T bVS ?CL?7 Wa +& +')*& +')+& +'),& +')-& +').& +') / & +')0& +')1& +')2& +'*&+'**& +'*+& +'*,& +'*-& +'*.& +'* / & +'*0& +'*1& +'*2& +'+& +'+*& +'++& +'+,& +'+-& +'+.& +'+ / & +'+0&+'+1& +'+2& +',& +',*& +',+& +',,& +',-& +',.& +', / & +',0& +',1& +',2& +'-& +'-*& +'-+& +'-,& +'--&+'-.& +'- / & +'-0& +'-1& +'-2& ]` +'. [WZZW]\ ROZb]\a& eVS`SOa bVS Cd ]T bVS BCL?7 Wa )',& )',*&)',+& )',,& )',-& )',.& )', / & )',0& )',1& )',2& )'-& )'-*& )'-+& )'-,& )'--& )'-.& )'- / & )'-0& )'-1&)'-2& ]` )'. [WZZW]\ ROZb]\a' @\ ]\S S[P]RW[S\b& bVS VgOZc`]\O\ ZOgS` W\QZcRSa ?CL?7VOdW\U bVS Cd ]T +'*1 [WZZW]\ ROZb]\a O\R BCL?7 VOdW\U bVS Cd ]T )',1 [WZZW]\ ROZb]\a'

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[0057] @\ ORRWbW]\ b] ?CL?7 O\R BCL?7& bVS VgOZc`]\O\ ZOgS` [Og Tc`bVS` W\QZcRSSfQW^WS\ba acQV Oa Ob ZSOab ]\S PW\RS`' @\ ]\S S[P]RW[S\b& bVS VgOZc`]\O\ ZOgS` W\QZcRSa?CL?7 O\R BCL?7 W\ O eSWUVb `ObW] ]T -3*'

[0058] 7QQ]`RW\U b] QS`bOW\ S[P]RW[S\ba ]T bVS ^`SaS\b RWaQZ]ac`S& bVS VgOZc`]\O\ ZOgS`Tc`bVS` W\QZcRSa Ob ZSOab ]\S PW\RS` W\ O\ O[]c\b ]T ,) b] -2 eb! ]T bVS VgOZc`]\O\ ZOgS`'IVS PW\RS` acWbOPZS T]` caS W\ bVS VgOZc`]\O\ ZOgS` [Og PS O\g ]T bVS PW\RS`a RSaQ`WPSR OP]dST]` bVS [SaOZO[W\S ZOgS`' @\ dO`W]ca S[P]RW[S\ba& bVS PW\RS` caSR W\ bVS VgOZc`]\O\ ZOgS`[Og PS bVS aO[S Oa ]` RWTTS`S\b T`][ bVOb caSR W\ bVS [SaOZO[W\S ZOgS`' @\ ]\S S[P]RW[S\b&bVS PW\RS` caSR W\ bVS VgOZc`]\O\ ZOgS` W\QZcRSa Z]e#acPabWbcbSR VgR`]fg^`]^gZ QSZZcZ]aS'

[0059] IVS PW\RS` QO\ PS Q][^`WaSR W\ bVS VgOZc`]\O\ ZOgS`& W\ O\ O[]c\b& T]` SfO[^ZS&`O\UW\U T`][ OP]cb ,) eb! b] -2 eb!& ,+ eb! b] -. eb!& ]` ,- eb! b] -, eb!& POaSR ]\ bVSb]bOZ eSWUVb ]T bVS VgOZc`]\O\ ZOgS`' C]`S a^SQWTWQOZZg& bVS PW\RS` QO\ PS Q][^`WaSR W\ bVSVgOZc`]\O\ ZOgS` W\ O\ O[]c\b ]T OP]cb ,)& ,*& ,+& ,,& ,-& ,.& , / & ,0& ,1& ,2& -)& -*& -+& -,& --&-.& - / & -0& -1& -2 eb!& POaSR ]\ bVS b]bOZ eSWUVb ]T bVS VgOZc`]\O\ ZOgS`'

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[0088] =]` [SaOZO[W\S& PZ]]R aO[^ZSa eS`S Q]]ZSR W\ O\ WQS PObV O\R QS\b`WTcUSR Ob ,&))) `^[T]` Ob ZSOab *) [W\cbSa Ob O^^`]fW[ObSZg -n9 "\] []`S bVO\ +-) [W\cbSa ^OaaSa PSbeSS\ bVSbW[S ]T SOQV PZ]]R R`Oe O\R bVS abO`b ]T QS\b`WTcUObW]\#' Ie] OZW_c]ba ]T Ob ZSOab )'. [B"eVS\ ^]aaWPZS# ]T ^ZOa[O eS`S RWa^S\aSR W\b] ^]Zg^`]^gZS\S bcPSa Oa a]]\ Oa ^]aaWPZS' IVSOZW_c]ba eS`S b`O\aTS``SR b] O #1)n9 "# / .n9 b] #1.n9# T`SShS` "\] []`S bVO\ *1) [W\cbSa ^OaaSaPSbeSS\ bVS abO`b ]T QS\b`WTcUObW]\ O\R OZW_c]b ab]`OUS#& ^S\RW\U O\OZgaWa' =]` ?7& PZ]]RaO[^ZSa eS`S OZZ]eSR b] QZ]b Ob `]][ bS[^S`Obc`S T]` Ob ZSOab ,) [W\cbSa T]ZZ]eW\U Q]ZZSQbW]\^`W]` b] PSW\U QS\b`WTcUSR Ob +-)) `^[ T]` Ob ZSOab *) [W\cbSa Ob `]][ bS[^S`Obc`S "\] []`SbVO\ / ) [W\cbSa ^OaaSR PSbeSS\ bVS bW[S ]T SOQV PZ]]R R`Oe O\R bVS abO`b ]T QS\b`WTcUObW]\#'Ie] OZW_c]ba ]T Ob ZSOab )'. [B "eVS\ ^]aaWPZS# ]T aS`c[ eS`S RWa^S\aSR W\b] ^]Zg^`]^gZS\SbcPSa Oa a]]\ Oa ^]aaWPZS' IVS OZW_c]ba eS`S b`O\aTS``SR b] O #1)n9 "# / .n9 b] #1.n9# T`SShS`"\] []`S bVO\ *+) [W\cbSa ^OaaSR PSbeSS\ bVS abO`b ]T QS\b`WTcUObW]\ O\R OZW_c]b ab]`OUS#&^S\RW\U aVW^[S\b b] bVS O\OZgbWQOZ TOQWZWbg'

[0089] IVS ^VO`[OQ]YW\SbWQ "FA# ^O`O[SbS`a OaaSaaSR eS`S US\S`OZZg abO\RO`R O\R bVS PZ]]RaO[^ZW\U aQVSRcZS eOa RSbS`[W\SR POaSR ]\ ^`S#QZW\WQOZ FA RObO' @\ ORRWbW]\ b] bVS cacOZ FA^O`O[SbS`a& ^O`bWOZ 7J9a "7J91#-1& 7J9 / #*+& 7J9*+#+-& O\R 7J9`STI[Of# eS`S OZa] b] PS QOZQcZObSRW\ bVWa abcRg T]` OZZ b`SOb[S\b U`]c^a& W\ O\ ObbS[^b b] Q][^O`S bV]`]cUVZg R`cU OPa]`^bW]\"O\R bVS`ST]`S R`cU OdOWZOPWZWbg# Ob bVS aWbS ]T OQbW]\ W\ bVS Q]Z]\' ;ObO eS`S O\OZghSR caW\UO\OZgaWa ]T dO`WO\QS "7DEK7#' IVS _cO\bWbObWdS RObO O`S ^`SaS\bSR Oa [SO\ o abO\RO`RRSdWObW]\'

[0090] $6ACE=8 '@B>E=6D<@?

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[0093] 08CE=DC

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[0099] =c`bVS`[]`S& I`SOb[S\b 7 OQVWSdSa O aWU\WTWQO\bZg VWUVS` 9[Of Q][^O`SR b] I`SOb[S\b 9&[]`S bVO\ bV`SS bW[Sa VWUVS` ",*,'+0!#' IVWa& W\ Q][PW\ObW]\ eWbV O I[Of ]T / V]c`a ]TI`SOb[S\b 7& acUUSaba bVOb I`SOb[S\b 7 RSZWdS`a O []`S Q]\QS\b`ObSR O[]c\b ]T [SaOZO[W\Sb] bVS PZ]]Rab`SO[ ]\QS Wb `SOQVSa bVS Q]Z]\& eVWQV QO\ PS ^O`bWQcZO`Zg PS\STWQWOZ W\ aWbcObW]\aeVS`S `O^WR ag[^b][ `SZWST Wa \SSRSR' =]` ^ObWS\ba Sf^S`WS\QW\U OQcbS TZO`Sa ]T cZQS`ObWdSQ]ZWbWa& VOdW\U O T]`[cZObW]\ bVOb ^`]dWRSa TOab ]\aSb ]T OQbW]\ Wa O Q`WbWQOZ ORdO\bOUS& Oa Wb QO\VSZ^ `SRcQS W\TZO[[ObW]\ O\R RWaQ][T]`b []`S _cWQYZg bVO\ O T]`[cZObW]\ eWbV aZ]eS` `SZSOaS"ZWYS I`SOb[S\b 9#'

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[0102] IVS ZSOab#a_cO`Sa [SO\a `ObW]a "8(7# ]T I`SOb[S\b 8 "bVS [SaOZO[W\S +)) [U ;GQO^acZS# b] I`SOb[S\b 7 "bVS [SaOZO[W\S#a]RWc[ VgOZc`]\ObS +)) [U#+, [U ;G QO^acZS# ]TZ\#b`O\aT]`[SR 7J9)#b& 7J9)#W\T& 9[Of& 7J9 / #*+& 7J9*+#+-& 7J91#-1& O\R 7J9`STI[Of eS`S `Sa^SQbWdSZg0+' / -!& 1*'2.!& 1*'+*!& 0,'.+!& / ,'20!& 0.'))!& O\R 0)'*.!'

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Claims

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