Formulation for oral administration of non-naturally occurring melanocortin analogs

Abstract

The present technology comprises pharmaceutical compositions of non-naturally occurring melanocortin analogs formulated for oral administration. The non-naturally occurring melanocortin analogs may be agonists or antagonists of the melanocortin 4 receptor (MC4R) and / or the melanocortin 3 receptor (MC3R) with sub-micromolar or low-nanomolar binding activity, or may be agonists of the melanocortin 1 receptor (MC1R) with sub-micromolar or low-nanomolar binding activity.

Description

Docket No.: 183B-412994-WOFORMULATION FOR ORAL ADMINISTRATION OF NON-NATURALLY OCCURRING MELANOCORTIN ANALOGSCROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of U.S. Provisional Patent Application No. 63 / 759,024, filed February 14, 2025; U.S. Provisional Patent Application No. 63 / 759,023, filed February 14, 2025; U.S. Provisional Patent Application No. 63 / 759,025, filed February 14, 2025; and U.S. Provisional Patent Application No. 63 / 704,519, filed October 7, 2024, all of which are incorporated herein by reference in their entirety.INCORPORATION BY REFERENCE OF SEQUENCE LISTING

[0002] This application contains an ST.26 compliant Sequence Listing, which is submitted concurrently in xml format and is hereby incorporated by reference in its entirety. The .xml copy, created on October 3, 2025 is titled “183B-412994-WO_SL.xml” and is 1 ,294,500 bytes in size.BACKGROUND

[0003] Various routes of administration, including subcutaneous (SC), intravenous (IV), and oral, have been employed to deliver medications. Among these, oral administration may be preferred by both users and healthcare providers due to its non-invasive nature, ease of use, and patient compliance. Despite the availability of SC and IV administration routes, which may be effective in delivering certain medications, these require healthcare professional intervention or self-administration techniques that can cause discomfort, administration site irritation, and potential complications. In comparison, oral drug formulations may be advantageous over SC and IV by alleviating these issues.

[0004] As such, there is a need for oral drug formulations that leverage the benefits of oral administration over other routes, while simultaneously increasing bioavailability of such oral dug formulations.-1 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOSUMMARY

[0005] Provided herein are pharmaceutical compositions comprising non-naturally occurring melanocortin analogs for oral administration.

[0006] In one aspect, the present technology relates to an orally deliverable pharmaceutical composition comprising a non-naturally occurring melanocortin analog, the non-naturally occurring melanocortin analog comprising a sequence of Formula (I):X1-X2-X3- R1- R2- R3- R4- R5- R6-R7-Y1-Y2-Y3-Y4( I ) , wherein:X1is absent, D-valine (dVal), or norleucine (Nle);X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of aspartic acid (Asp), Nle, D- norleucine (dNIe), hisitdine (His), D-histidine (dHis), D-phenylalanine (dPhe), arginine (Arg), D-arginine (dArg) and D-proline (dPro);R2is selected from the group consisting of Asp, proline (Pro), lysine (Lys), cysteine (Cys), D-cysteine (dCys), D-penicillamine (dPen), penicillamine (Pen), glutamic acid (Glu), and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, dPro, tryptyl-proline (Trp-Pro), tryptyl-D-leucine (Trp-dLeu), trytpyl-D-valine (Trp-dVal), D-isoleucine (dlle), D- alanine (dAla), D-methionine (dMet), glycine (Gly), glycyl-glycine (Gly-Gly), beta-alanine (p-Ala), 3-aminomethyl-benzoic acid (Mamb), 1 -amino-1 -cyclopentane carboxylic (Cpe), 1 - amino-1 -cyclohexanecarboxylic acid (Che), 1 -aminocyclo-propane-1 -carboxylic acid (Acpc), prolyl-proline (Pro-Pro), prolyl-hisitdine (Pro-His), phenylalanyl-proline (Phe-Pro), D-histidyl-proline (dHis-Pro), hydroxyproline (Hyp), prolyl-glutamic acid (Pro-Glu), glutamic acid-histidine (Glu-His), Arg, dPhe, biphenylalanine (Bip), D-biphenylalanine (dBip), D- tyrosine (dTyr), D-tryptophan (dTrp), leucine (Leu), dLeu, dVal, D-glutamine (dGIn), tryptyl- arginine (Trp-Arg), histidyl-arginine (His-Arg), prolyl-arginine (Pro-Arg), arginyl-proline (Arg-Pro), and alanine (Ala);R4is selected from the group consisting of 2’-D-naphthylalanine (dNal(2’)), Bip, dBip, dPhe, para-fluoro-D-phenylalanine (p(F)dPhe), para-chloro-D-phenylalanine-2-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO(p(CI)dPhe), para-iodo-D-phenylalanine (p(l)dPhe), and para-bromo-D-phenylalanine (p(Br)dPhe);R5is absent or selected from the group consisting of Arg, dArg, D-lysine (dLys), D- ornithine (dOrn), Glu, D-aspartic acid (dAsp), D-glutamic acid (dGlu), Pro, and His;R6is absent or is selected from the group consisting of Trp, tryptyl-glycine (Trp-Gly), tryptyl-proline (Trp-Pro), 2’-naphthylalanine (Nal(2’)), 1 ’-naphthylalanine (Nal(1 ’)), 1 ’-D- naphthylalanine (dNal(1 ’)), Phe, dPhe, and 1 ,2,3,4-tetrahydroisoquinoline carboxylic acid (Tic);R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, dOrn, and ornthine (Orn);Y1is selected from the group consisting of dVal, D-tert-leucine (dTle), dLys, Asp, D- threonine (dThr), p2-valine (p2Val), p3-valine (p3Val), Nle, Trp, dArg, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, p-proline (pPro), Nle, and valine (Vai);Y3is absent or selected from the group consisting of dVal, dThr, dPro, and Pro;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R1or R2and R7when R1or R2is Asp or CO-cis- CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that: when R4is dNal(2’), then R3is not Pro-His, Hyp, or Pro-Pro, R5is not His, R6is not Phe, dPhe, Nal(1 ’), or dNal(1 ’), and either (i) Y1is dVal, Y2is dPro, and Y3-Y4are absent (ii) Y1is dLys or dArg, and R2is dPen, or (iii) Y1is Nle,-3-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO when R4is p(F)dPhe, then R3is dPhe, dBip, dTyr, dTrp, or Pro, wherein when R3is Pro then either (i) R6is not Trp or (ii) Y1and Y2are each independently dVal or dTle, when R4is p(CI)dPhe, then R3is dPhe, dBip, dTyr, or His, wherein when R3is His then R1is dArg and Y1is dVal, when R4is p(Br)dPhe, then R3is dPhe, Bip, dTyr, dTrp, dGIn, or His, wherein when R3is His then either (i) R1is His or dHis and Y1is dTle or (ii) R2is dCys, when R4is p(l)dPhe, then R3is Arg-Pro, when R4is dBip, then R2is Asp and R3is not Pro, when R4is dNal(2’) and R3is Pro, then R1is absent, dPhe, or Nle and R6is Trp, wherein when R1is absent, then R2is CO-cis-CH=CH-CO, when R1is dPhe, then R2is dPen, and when R1is Nle, then (i) R2is Asp and either (a) R5is not Arg, Pro, or absent, (b) R7is not Lys, or (c) X1-X3are all Nle, (ii) R2and R7are each is dPen or (iii) R2is Pen or Cys, and R7is dCys, when R4is dNal(2’) and R3is Ala, Leu, Gly, or His, then either R2is dPen or R6is Trp-Pro, when R4is dNal(2’) and R3is Glu-His, then R6is Trp, when R4is dNal(2’) and R3is absent, then (i) R2is not Asp, (ii) R2and R7are not both Cys, and (iii) when R2is dCys, then R7is not Pen, when R4is dPhe and R3is Pro, then the N-terminus is acetylated, X1-X2are each independently absent or Nle, X3is absent, R1is dNIe, dPhe or Nle, R2is Cys or Asp, R5is Arg or Pro, R6is Trp or dNal(T), the C-terminus is amidated, wherein when R1is Nle, then either (i) Y1is dVal, Y2is dPro and at least one of X1-X2is Nle, (ii) Y1is dVal or Lys and Y2is dArg or Vai, or (iii) Y1is dLys, Asp, dThr, p2Val, or p3Val, and Y2is not dVal, and when R4is dPhe, and R3is not Pro, then the N-terminus is acetylated, X1-X3are absent, R1is absent, Nle, Arg, or dArg, Y1is dVal, Y2is dPro and Y3-Y4are absent, ad (i) R3is absent and R2or R7is Cys, (ii) R3is Trp-Pro and either (a) R5is His, (b) R6is Nal(1 ’), dNal(1 ’), Phe, or dPhe, or (c) R7is dCys, (iii) R3is Pro-His, R1is Nle and R5is His, (iv) R3is Hyp or dAla and either R1is not Nle or R6is not Trp, (v) R3is His and R5is Pro, or (vi) R3is selected from dBip, Pro-Pro, Arg, dVal, Cpe, Che, Phe-Pro, dHis-Pro, dlle, Trp-Leu, and Trp-dVal.-4-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0007] In another aspect, the present technology relates to a pharmaceutical composition comprising a non-naturally occurring melanocortin receptor analog and a permeation enhancer, the non-naturally occurring melanocortin receptor analog comprising a sequence of Formula (I).

[0008] In another aspect, the present technology relates to a pharmaceutical composition for oral administration of a non-naturally occurring melanocortin receptor analog, the composition comprising a permeation enhancer and a non-naturally occurring melanocortin receptor analog comprising a sequence of Formula (I).

[0009] In yet another aspect, the present technology relates to a pharmaceutical composition formulated to deliver about 0.1 mg / kg to about 5 mg / kg, per body weight of a subject, of a non-naturally occurring melanocortin receptor analog to the subject, the pharmaceutical composition comprising: a permeation enhancer; and a non-naturally occurring melanocortin receptor analog comprising a sequence of Formula (I).

[0010] Also provided herein are oral dosage units of the pharmaceutical compositions described herein and methods of administering the same.BRIEF DESCRIPTION OF THE DRAWINGS

[0011] FIG. 1 shows TCMCB07 (Ac-Nle-c[Asp-Pro-dNal(2’)-Arg-Trp-Lys]-dVal-dPro- NH2; SEQ ID NO: 2) levels in human plasma, simulated gastric fluid (SGF), and simulated intestinal fluid (SIF) over a 120-minute incubation period.

[0012] FIG. 2 shows TCMCB07 (Ac-Nle-c[Asp-Pro-dNal(2’)-Arg-Trp-Lys]-dVal-dPro- NH2; SEQ ID NO: 2) plasma concentration after oral administration in cynomolgus monkeys at 30.0 mg / kg.

[0013] FIG. 3 shows Compound A (Ac-Nle-c(Asp-Pro-dNal(2')-Arg-Trp-Lys)-dArg- dPro-NH2; SEQ ID NO: 3) plasma concentration after oral administration in cynomolgus monkeys at 30.0 mg / kg.

[0014] FIG. 4 shows side-by-side plasma concentration of TCMCB07 (Ac-Nle-c[Asp- Pro-dNal(2’)-Arg-Trp-Lys]-dVal-dPro-NH2; SEQ ID NO: 2) and Compound A (Ac-Nle-c(Asp--5-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOPro-dNal(2')-Arg-Trp-Lys)-dArg-dPro-NH2; SEQ ID NO: 3) after oral administration in cynomolgus monkeys at 30.0 mg / kg.

[0015] FIGS. 5A and 5B show plasma concentrations of melanocortin analogs in cynomolgus monkeys orally administered A07D (Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]- dVal-dPro-NH2; SEQ ID NO: 4) and 03 (Ac-dLys-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dLys-dVal- dPro-NH2; SEQ ID NO: 5) at 10 mg / kg and 30 mg / kg.DETAILED DESCRIPTION

[0016] Described herein are pharmaceutical compositions comprising non-naturally occurring melanocortin analogs (also referred to herein as “melanocortin analogs” and “melanocortin analogs”) formulated for oral administration to a subject. In order to achieve desired therapeutic outcomes, the pharmaceutical compositions are specifically formulated with one or more components useful for oral delivery of the non-naturally occurring melanocortin analog. The pharmaceutical compositions of the present technology and the one or more components thereof may be Generally Recognized as Safe (GRAS) under one or more conditions of the present technology. In some embodiments, the one or more components of the pharmaceutical composition are selected based on desirable pharmacokinetic properties.

[0017] The following description is merely exemplary in nature and is not intended to limit the present technology, its applications, or its uses. It should be understood that throughout the drawings, corresponding reference numerals indicate like or corresponding parts and features. The description of specific examples indicated in various embodiments of the present technology are intended for purposes of illustration only and are not intended to limit the scope of the present technology disclosed herein. Moreover, recitation of multiple embodiments having stated features is not intended to exclude other embodiments having additional features or other embodiments incorporating different combinations of the stated features.

[0018] Furthermore, the detailed description of various embodiments herein makes reference to the accompanying drawing / FIGS, which show various embodiments by way of illustration. While the embodiments are described in sufficient detail to enable those skilled-6-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO in the art to practice the present technology, it should be understood that other embodiments may be realized, and that logical changes may be made without departing from the spirit and scope of the present technology. Thus, the detailed description herein is presented for purposes of illustration only and not of limitation. For example, steps recited in any method or process, may be executed in any order and are not limited to the order presented. Moreover, any of the steps thereof may be outsourced to or performed by one or more third parties.Definitions

[0019] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the art to which the present technology belongs. For the purposes of the present technology, the following terms are defined below.

[0020] The articles “a” and “an” are used herein to refer to one or to more than one (i.e., to at least one) of the grammatical object of the article. By way of example, “an element” means one element or more than one element.

[0021] The term “about” means a quantity, level, value, number, frequency, percentage, dimension, size, amount, weight or length that varies by acceptable levels in the art. Typically, such variation may be as much 10% above and below a reference quantity, level, value, number, frequency, percentage, dimension, size, amount, weight or length and such variation may be influenced by standard applicable measurement practices. When the term “about” is used in conjunction with a numerical range, it modifies that range by extending the boundaries above and below the numerical values set forth.

[0022] As used herein, “oral administration” and “orally deliverable” include any form of delivery of a non-naturally occurring melanocortin receptor analog or a composition thereof to a subject wherein the non-naturally occurring melanocortin receptor analog or the composition is placed in the mouth of the subject, whether or not the non-naturally occurring melanocortin receptor analog or composition is swallowed. Thus, “oral administration” includes buccal and sublingual, as well as esophageal administration.-7-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0023] The terms “active ingredient” and “active compound” refer to a biologically active substance, whether naturally or non-naturally occurring, that is the main component of the pharmaceutical composition which elicits the intended effect of an administered therapeutic. This can be any component that drives the pharmacological activity or direct effect in the diagnosis, cure, mitigation, treatment, or prevention of the conditions associated with the present technology.

[0024] The terms “composition,” “pharmaceutical composition,” “formulation,” and “pharmaceutical formulation” are used interchangeably herein to refer to a mixture of the active ingredient with one or more components, such as pharmaceutically acceptable carriers and / or excipients.

[0025] As used herein, a “pharmaceutically acceptable carrier” refers to a carrier or diluent that does not cause significant irritation to an organism, does not abrogate the biological activity and properties of the administered active ingredient, and / or does not interact in a deleterious manner with the other components of the composition in which it is contained. The term “carrier” encompasses any excipient, binder, diluent, filler, salt, buffer, solubilizer, lipid, stabilizer, or other material well known in the art for use in pharmaceutical formulations. The choice of a carrier for use in a composition will depend upon the intended route of administration for the composition. The preparation of pharmaceutically acceptable carriers and formulations containing these materials is described in, e.g., Remington's Pharmaceutical Sciences, 21 st Edition, ed. University of the Sciences in Philadelphia, Lippincott, Williams & Wilkins, Philadelphia Pa., 2005, which is incorporated herein by reference in its entirety).

[0026] As used herein, the terms “effective amount” or “therapeutically effective amount”, refer to that amount of the active ingredient being administered which will relieve to some extent one or more of the symptoms of the disease being treated. The result can be a reduction and / or alleviation of the signs, symptoms, or causes of a disease, or any other desired alteration of a biological system. An appropriate “effective amount” can differ from one individual to another. An appropriate “effective amount” in any individual case can be determined using techniques, such as a dose escalation study.-8-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0027] The terms “subject” and “patient” refer to anyone being evaluated for disease or condition or being administered a therapeutic or pharmaceutical composition. This includes people without diagnosed or confirmed disease or condition. This also includes people with diagnosed or confirmed disease or condition.

[0028] The term “control subject,” as used herein, refers to any subject used as a basis for comparison to the subject (e.g., test subject). A control subject includes, but is not limited to, any subject who has not been administered the therapeutic or pharmaceutical composition (e.g., the non-naturally occurring melanocortin receptor analog, a therapeutically effective amount of the non-naturally occurring melanocortin receptor analog or a pharmaceutical composition thereof) or administered a placebo.

[0029] “Melanocortin analogs,” “melanocortin peptides,” and “melanocortins,” are used interchangeably and refer to melanocortin-receptor ligands, which are macromolecules containing at least one melanocortin pharmacophore. Melanocortin analogs are typically peptides that bind melanocortin receptors under physiological conditions. Melanocortin analogs include non-naturally occurring melanocortin peptides and truncated and / or modified versions of melanocortin full-length protein or peptides. For example, the full-length pro-opiomelanocortin protein (POMC), prior to proteolytic cleavage of “sub-peptides,” consists of 241 amino acids. Tissue-specific proteolytic cleavage of POMC yields peptides ranging in size from 13 amino acids to 76 amino acids. See Bicknell and Lawry, Encyclopedia of Stress, vol. 3, 257-265, Academic Press (2000). Synthesized, non- naturally occurring melanocortin analogs having increased melanocortin receptor activity as discussed herein are approximately 7-12 amino acids in size. Melanocortin analogs exhibit binding functionality with melanocortin receptors. In addition to peptides, the non-naturally occurring melanocortin receptor analog s include small molecule analogs of melanocortin or portions thereof comprised of organic compounds, inorganic compounds, or combinations of peptide and small molecule — i.e., peptide mimetics, or various combinations thereof. “Melanocortin peptides” can be structurally similar and / or functionally similar to biological melanocortin proteins in their ability to bind melanocortin receptors. Further, the non- naturally occurring melanocortin receptor analog s generally contain the pharmacophore:-9-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOHis-Phe-Arg-Trp (SEQ ID NO: 1 ) or a modified version thereof, or a structural or functional peptide mimetic thereof.

[0030] A “pharmacophore” is the minimum set of amino acid residues necessary to achieve a physiological effect; or a small molecule that is (with respect to a receptor) a structural mimic of the amino acid residues required for binding to and activation of a receptor. His-Phe-Arg-Trp (SEQ ID NO: 1 ) and their analogs are the pharmacophore of melanocortin for the regulated physiological effect. Therefore, non-naturally occurring melanocortin pharmacophore analogs can be small peptides or organic molecules designed to mimic the appearance or function (including activation or deactivation of receptor activity) of the melanocortin pharmacophore core sequence peptide.

[0031] The terms “bind,” “binding,” “complex,” and “complexing,” refer to all types of physical and chemical binding, reactions, complexing, attraction, chelating and the like.

[0032] The “peptides” described herein can be (a) naturally occurring, (b) produced by chemical synthesis, (c) produced by recombinant DNA technology, (d) produced by biochemical or enzymatic fragmentation of larger molecules, (e) produced by methods resulting from a combination of methods (a) through (d) listed above, or (f) produced by any other means for producing peptides.

[0033] The term “peptide” as used herein includes any structure comprised of two or more amino acids, including chemical modifications and derivatives of amino acids. The amino acids forming all or a part of a peptide may be naturally occurring amino acids, stereoisomers and modifications of such amino acids, non-protein amino acids, post- translationally modified amino acids, enzymatically modified amino acids, constructs or structures designed to mimic amino acids, and the like, so that the term “peptide” includes pseudopeptides and peptidomimetics, including structures which have a non-peptidic backbone. The term “peptide” also includes dimers or multimers of peptides. A “manufactured” peptide includes a peptide produced by chemical synthesis, recombinant DNA technology, biochemical, or enzymatic fragmentation of larger molecules, combinations of the foregoing or, in general, made by any other method. The term “peptide” includes peptides containing a variable number of amino acid residues, optionally with non--10-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO amino acid residue groups at the N- and C-termini, such groups including acyl, acetyl, alkenyl, alkyl, N-alkyl, amine, or amide groups, among others.

[0034] By employing chemical synthesis, a useful means of production, it is possible to introduce various amino acids which do not naturally occur along the chain, modify the N- or C-terminus, and the like, thereby providing for improved stability and formulation, resistance to protease degradation, and the like.

[0035] “Amino acids” are molecules containing an amine group, a carboxylic acid group, and a side-chain that is specific to each amino acid. The key elements of an amino acid are carbon, hydrogen, oxygen, and nitrogen and have the generic formula H2N — CHR — COOH, wherein R represents a side chain group. The various a-amino acids differ in the side-chain moiety that is attached to the a-carbon. The “amino acids” of the present technology include the known naturally occurring protein amino acids, which are referred to by both their common three letter abbreviation and single letter abbreviation. See generally Synthetic Peptides: A User’s Guide, G. A. Grant, editor, W.H. Freeman & Co., New York (1992), the teachings of which are incorporated herein by reference, including the text and table set forth at pages 11 through 24. As set forth above, the term “amino acid” also includes stereoisomers and modifications of naturally occurring protein amino acids, nonprotein amino acids, post-translationally modified amino acids, enzymatically synthesized amino acids, derivatized amino acids, constructs or structures designed to mimic amino acids, and the like. Modified and unusual amino acids are described generally in Synthetic Peptides: A User’s Guide, supra; Hruby et al., Biochem. J. 268:249-262 (1990); and Toniolo, Int. J. Peptide Protein Res. 35:287-300 (1990); the teachings of all of which are incorporated herein by reference.

[0036] The phrase “amino acid side chain moiety” used herein, including as used in the specification and claims, includes any side chain of any amino acid, as the term “amino acid” is defined herein. This thus includes the side chain moiety present in naturally occurring amino acids. It further includes side chain moieties in modified naturally occurring amino acids, such as glycosylated amino acids. It further includes side chain moieties in stereoisomers and modifications of naturally occurring protein amino acids, non-protein amino acids, post-translationally modified amino acids, enzymatically synthesized amino-11 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO acids, derivatized amino acids, constructs, or structures designed to mimic amino acids, and the like. For example, the side chain moiety of any amino acid disclosed herein is included within the definition. A “derivative” of an amino acid side chain moiety is included within the definition of an amino acid side chain moiety.

[0037] The “derivative” of an amino acid side chain moiety includes any modification to or variation in any amino acid side chain moieties, including a modification of naturally occurring amino acid side chain moieties. By way of example, derivatives of amino acid side chain moieties include straight chain or branched, cyclic or noncyclic, substituted or unsubstituted, saturated or unsaturated, alkyl, aryl or aralkyl moieties.

[0038] In the peptides described herein, conventional amino acid residues have their conventional meaning as given in Chapter 2400, of the Manual of Patent Examining Procedure, 8th Ed. Thus, “Ala” is alanine; “Arg” is arginine; “Asn” is asparagine; “Asp” is aspartic acid; “Cys” is cysteine; “Gin” is glutamine; “Glu” is glutamic acid; “His” is histidine; “lie” is isoleucine; “Leu” is leucine; “Lys” is lysine; “Met” is methionine; “Phe” is phenylalanine; “Pro” is proline; “Ser” is serine; Thr is threonine; “Trp” is tryptophan; “Tyr” is tryosine; and “Vai” is valine. Unless otherwise indicated, all amino acids abbreviations represent either isomer, i.e., the L-isomer, the D-isomer, or combinations thereof can be used. Thus, for example, “L-Phe” or “IPhe” is L-phenylalanine; “D-Phe” or “dPhe” is D- phenylalanine; “D- / L-Phe” or “d / IPhe” is D-phenylalanine, L-phenylalanine, or combinations thereof; and “Phe” is D-phenylalanine, L-phenylalanine, or combinations thereof, and so on.

[0039] An alpha (oc)-amino acid has the generic formula H2N — CocHR — COOH, where R is a side chain moiety and the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (i.e., the oc-carbon). Other types of amino acids exist when the amino group is attached to a different carbon atom. For example, beta (p)-amino acids, the carbon atom to which the amino group is attached is separated from the carboxylate group by one carbon atom, Cp.

[0040] When p-amino acids are incorporated into peptides, two main types of p- peptides exist: those with the side chain residue, R, on the carbon next to the amine are called p3peptides and those with the side chain residue on the carbon next to the carbonyl-12-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO group are called p2amino acids. Further, p-amino acids may adopt L- or D- stereochemistry. Unless otherwise indicated, all p-amino acid abbreviations represent either isomer, i.e., the L-isomer, the D-isomer, or combinations thereof.

[0041] Gamma (y)-amino acids are amino acids with the carbon atom to which the amino group attaches is separated from the carboxylate moiety by two carbon atoms.

[0042] For additional modified and unusual amino acids, see §2422 of the MPEP, particularly Table 4 at 2400-24. Additionally, “Ac” indicates N-acetyl and “cyclo” refers to a cyclic structure, which is also shown in the literature as “c” or referred to as a “lactam.” “NH2” indicates an amine group, typically added on the C-terminus of a polypeptide. Accordingly, as used herein, an — NH2 moiety on the C-terminus of a peptide indicates an amidated C- terminus.

[0043] The term “acyl” includes a group RCO — , where R is an organic group. An example is the acetyl group CH3CO — , referred to herein as “Ac.”

[0044] A peptide is “acylated” when an alkyl or substituted alkyl group as defined above is bonded through one or more carbonyl { — (C=O) — } groups. A peptide is most usually acylated at the N-terminus.

[0045] An “amine” includes compounds that contain an amine group ( — NH2).

[0046] An “amide” includes compounds that have a trivalent nitrogen attached to a carbonyl group (i.e., — CO — NH2), such as for example methylamide, ethylamide, propylamide, and the like. A peptide is most usually amidated at the C-terminus by the addition of an amine ( — NH2) moiety to the C-terminal carboxyl group.

[0047] Amino acids, including stereoisomers and modifications of naturally occurring amino acids, protein amino acids, non-protein amino acids, post-translationally modified amino acids, enzymatically synthesized amino acids, derivatized amino acids, constructs, or structures designed to mimic amino acids (peptide mimetics), and the like, including all of the foregoing, are sometimes referred to herein as “residues.”-13-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0048] The disclosure of all publications, patents, and published patent applications listed herein are hereby incorporated by reference in their entireties, including but not limited to U.S. Patent Nos. 8,541 ,545 and 9,534,018 and PCT Publications No. WO 2025 / 123056.Pharmaceutical Compositions

[0049] The present technology provides pharmaceutical compositions comprising a non-naturally occurring melanocortin analog, wherein the composition is formulated for oral administration to a subject. In some embodiments, the pharmaceutical composition comprises one or more pharmaceutically acceptable carriers and / or excipients. In some embodiments, the pharmaceutical composition comprises a permeation enhancer. Pharmaceutical compositions comprising a melanocortin receptor analog and a permeation enhancer may have increased oral bioavailability compared to pharmaceutical compositions not comprising a permeation enhancer.

[0050] Pharmaceutical compositions of the present technology include a non-naturally occurring melanocortin analog as the active ingredient. Non-naturally occurring melanocortin analogs described herein may be selective for the melanocortin 1 receptor over other melanocortin receptors, i.e., the melanocortin 2, melanocortin 3, melanocortin 4, and melanocortin 5 receptors. Some of the melanocortin analogs bind only the melanocortin 1 receptor. Alternatively, some of the melanocortin analogs bind the melanocortin 1 receptor with substantially greater affinity than the melanocortin 5 receptor and exhibit no binding on the other melanocortin receptors.

[0051] Alternatively, non-naturally occurring melanocortin analogs described herein may be selective for the melanocortin 4 receptor and / or melanocortin 3 receptor over other melanocortin receptors, i.e., the melanocortin 1 , melanocortin 2, and melanocortin 5 receptors. Some of the melanocortin analogs bind only the melanocortin 3 receptor or the melanocortin 4 receptor. Alternatively, some of the melanocortin analogs bind the melanocortin 3 receptor with greater affinity than the melanocortin 4 receptor, whereas other melanocortin analogs can bind the melanocortin 4 receptor with greater affinity than the melanocortin 3 receptor. Certain melanocortin analogs bind the melanocortin 3 receptor with the same or generally similar affinity as the melanocortin 4 receptor.-14-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0052] The non-naturally occurring melanocortin analogs of the present technology may be full antagonists or full agonists for one or more melanocortin receptors. A full antagonist may comprise a non-naturally occurring melanocortin analog having a maximum effect (Emax) antagonist value of greater than or equal to 80%. Likewise, a full agonist may comprise a non-naturally occurring melanocortin analog having a maximum effect (Emax) agonist value of greater than or equal to 80%.

[0053] The non-naturally occurring melanocortin analogs of the present technology may be partial agonists of one or more melanocortin receptor. A partial agonist may comprise a non-naturally occurring melanocortin analog having a maximum effect Emax agonist value of less than 80%.

[0054] If a non-naturally occurring melanocortin analog’s Emax antagonist value is greater than it’s Emax agonist value, then the non-naturally occurring melanocortin analog may be classified as an agonist (e.g., a full agonist or a partial agonist). Similarly, if a non- naturally occurring melanocortin analog’s Emax agonist value is greater than it’s Emax antagonist value, then the non-naturally occurring melanocortin analog may be classified as an antagonist (e.g., a full antagonist or a partial antagonist).

[0055] The non-naturally occurring melanocortin analogs of the present technology may be one or more of (i) a full MC1 R agonist and a partial MC5R agonist; (ii) a full MC1 R antagonist having no activity on MC5R; (iii) a partial MC1 R antagonist having no activity on MC5R; (iv) a full MC1 R agonist and a full MC5R agonist demonstrating substantially greater binding affinity for MC1 R; (v) a partial MC1 R agonist and a partial MC5R agonist demonstrating substantially greater binding affinity for MC1 R, (vi) a full MC4R antagonist and a full MC3R agonist; (vii) a full MC4R antagonist and a partial MC3R agonist; (viii) a full MC4R antagonist having no MC3R agonist or antagonist activity; (ix) a partial MC4R antagonist having no MC3R agonist or antagonist activity; or (x) a full MC4R agonist and a full MC3R antagonist. In some embodiments, the non-naturally occurring melanocortin analogs of the present technology may be one or more of (i) a full MC1 R agonist and a partial MC5R agonist; (ii) a full MC1 R antagonist having no activity on MC5R; (iii) a partial MC1 R antagonist having no activity on MC5R; (iv) a full MC1 R agonist and a full MC5R agonist demonstrating substantially greater binding affinity for MC1 R; or (v) a partial MC1 R-15-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO agonist and a partial MC5R agonist demonstrating substantially greater binding affinity for MC1 R. In some embodiments, the non-naturally occurring melanocortin analogs of the present technology may be one or more of (i) a full MC4R antagonist and a full MC3R agonist; (ii) a full MC4R antagonist and a partial MC3R agonist; (iii) a full MC4R antagonist having no MC3R agonist or antagonist activity; (iv) a partial MC4R antagonist having no MC3R agonist or antagonist activity; or (v) a full MC4R agonist and a full MC3R antagonist.

[0056] The non-naturally occurring melanocortin analogs in accordance with the present technology may have structural features that impart specific properties on the analogs, such as, for example, degradation resistance, enhanced epithelial, gastrointestinal, and / or blood brain barrier transport, and binding affinity for the MC4R and / or MC3R or for the MC1 R. For example, in some embodiments, the non-naturally occurring melanocortin analogs comprise one or more of (i) blood brain barrier passage capabilities, (ii) enhanced epithelial and / or gastrointestinal transport; or (iii) degradation resistance. In some embodiments, the non-naturally occurring melanocortin analogs comprise two or more of (i)- (iii). In some embodiments, the non-naturally occurring melanocortin analogs comprise each of (i)-(iii). Accordingly, in some embodiments, the melanocortin analogs include a stabilizing N-terminus, and / or a C-terminus that provides enhanced transport of the analog. In some embodiments, melanocortin analogs include a D-valine-D-proline (dVal-dPro) chain as their C-terminus, which may provide enhanced transport and resistance to degradation Additionally, in some embodiments, the melanocortin analogs have one or more beta hairpin (p-hairpin) and / or beta turn (p-turn) structures. In general, cyclization and D-amino acids may induce and / or stabilize beta-turns.

[0057] In some embodiments, the non-naturally occurring melanocortin analog comprises a sequence of Formula (I):X1-X2-X3- R1- R2- R3- R4- R5- R6- R7- Y1- Y2-Y3- Y4( I ) , wherein:X1is absent, D-valine (dVal), or norleucine (Nle);X2is absent or Nle;X3is absent or Nle;-16-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOR1is absent or is selected from the group consisting of aspartic acid (Asp), Nle, D- norleucine (dNIe), hisitdine (His), D-histidine (dHis), D-phenylalanine (dPhe), arginine (Arg), D-arginine (dArg) and D-proline (dPro);R2is selected from the group consisting of Asp, proline (Pro), lysine (Lys), cysteine (Cys), D-cysteine (dCys), D-penicillamine (dPen), penicillamine (Pen), glutamic acid (Glu), and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, dPro, tryptyl-proline (Trp-Pro), tryptyl-D-leucine (Trp-dLeu), trytpyl-D-valine (Trp-dVal), D-isoleucine (dlle), D- alanine (dAla), D-methionine (dMet), glycine (Gly), glycyl-glycine (Gly-Gly), beta-alanine (p-Ala), 3-aminomethyl-benzoic acid (Mamb), 1 -amino-1 -cyclopentane carboxylic (Cpe), 1 - amino-1 -cyclohexanecarboxylic acid (Che), 1 -aminocyclo-propane-1 -carboxylic acid (Acpc), prolyl-proline (Pro-Pro), prolyl-hisitdine (Pro-His), phenylalanyl-proline (Phe-Pro), D-histidyl-proline (dHis-Pro), hydroxyproline (Hyp), prolyl-glutamic acid (Pro-Glu), glutamic acid-histidine (Glu-His), Arg, dPhe, biphenylalanine (Bip), D-biphenylalanine (dBip), D- tyrosine (dTyr), D-tryptophan (dTrp), leucine (Leu), dLeu, dVal, D-glutamine (dGIn), tryptyl- arginine (Trp-Arg), histidyl-arginine (His-Arg), prolyl-arginine (Pro-Arg), arginyl-proline (Arg-Pro), and alanine (Ala);R4is selected from the group consisting of 2’-D-naphthylalanine (dNal(2’)), Bip, dBip, dPhe, para-fluoro-D-phenylalanine (p(F)dPhe), para-chloro-D-phenylalanine (p(CI)dPhe), para-iodo-D-phenylalanine (p(l)dPhe), and para-bromo-D-phenylalanine (p(Br)dPhe);R5is absent or selected from the group consisting of Arg, dArg, D-lysine (dLys), D- ornithine (dOrn), Glu, D-aspartic acid (dAsp), D-glutamic acid (dGlu), Pro, and His;R6is absent or is selected from the group consisting of Trp, tryptyl-glycine (Trp-Gly), tryptyl-proline (Trp-Pro), 2’-naphthylalanine (Nal(2’)), 1 ’-naphthylalanine (Nal(1 ’)), 1 ’-D- naphthylalanine (dNal(1 ’)), Phe, dPhe, and 1 ,2,3,4-tetrahydroisoquinoline carboxylic acid (Tic);R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, dOrn, and ornthine (Orn);Y1is selected from the group consisting of dVal, D-tert-leucine (dTle), dLys, Asp, D- threonine (dThr), p2-valine (p2Val), p3-valine (p3Val), Nle, Trp, dArg, and Lys;-17-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOY2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, p-proline (pPro), Nle, and valine (Vai);Y3is absent or selected from the group consisting of dVal, dThr, dPro, and Pro;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R1or R2and R7when R1or R2is Asp or CO-cis- CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that: when R4is dNal(2’), then R3is not Pro-His, Hyp, or Pro-Pro, R5is not His, R6is not Phe, dPhe, Nal(1 ’), or dNal(1 ’), and either (i) Y1is dVal, Y2is dPro, and Y3-Y4are absent (ii) Y1is dLys or dArg, and R2is dPen, or (iii) Y1is Nle, when R4is p(F)dPhe, then R3is dPhe, dBip, dTyr, dTrp, or Pro, wherein when R3is Pro then either (i) R6is not Trp or (ii) Y1and Y2are each independently dVal or dTle, when R4is p(CI)dPhe, then R3is dPhe, dBip, dTyr, or His, wherein when R3is His then R1is dArg and Y1is dVal, when R4is p(Br)dPhe, then R3is dPhe, Bip, dTyr, dTrp, dGIn, or His, wherein when R3is His then either (i) R1is His or dHis and Y1is dTle or (ii) R2is dCys, when R4is p(l)dPhe, then R3is Arg-Pro, when R4is dBip, then R2is Asp and R3is not Pro, when R4is dNal(2’) and R3is Pro, then R1is absent, dPhe, or Nle and R6is Trp, wherein when R1is absent, then R2is CO-cis-CH=CH-CO, when R1is dPhe, then R2is dPen, and when R1is Nle, then (i) R2is Asp and either (a) R5is not Arg, Pro, or absent, (b) R7is not Lys, or (c) X1-X3are all Nle, (ii) R2and R7are each is dPen or (iii) R2is Pen or Cys, and R7is dCys,-18-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO when R4is dNal(2’) and R3is Ala, Leu, Gly, or His, then either R2is dPen or R6is Trp-Pro, when R4is dNal(2’) and R3is Glu-His, then R6is Trp, when R4is dNal(2’) and R3is absent, then (i) R2is not Asp, (ii) R2and R7are not both Cys, and (iii) when R2is dCys, then R7is not Pen, when R4is dPhe and R3is Pro, then the N-terminus is acetylated, X1-X2are each independently absent or Nle, X3is absent, R1is dNIe, dPhe or Nle, R2is Cys or Asp, R5is Arg or Pro, R6is Trp or dNal(T), the C-terminus is amidated, wherein when R1is Nle, then either (i) Y1is dVal, Y2is dPro and at least one of X1-X2is Nle, (ii) Y1is dVal or Lys and Y2is dArg or Vai, or (iii) Y1is dLys, Asp, dThr, p2Val, or p3Val, and Y2is not dVal, and when R4is dPhe, and R3is not Pro, then the N-terminus is acetylated, X1-X3are absent, R1is absent, Nle, Arg, or dArg, Y1is dVal, Y2is dPro and Y3-Y4are absent, ad (i) R3is absent and R2or R7is Cys, (ii) R3is Trp-Pro and either (a) R5is His, (b) R6is Nal(1 ’), dNal(1 ’), Phe, or dPhe, or (c) R7is dCys, (iii) R3is Pro-His, R1is Nle and R5is His, (iv) R3is Hyp or dAla and either R1is not Nle or R6is not Trp, (v) R3is His and R5is Pro, or (vi) R3is selected from dBip, Pro-Pro, Arg, dVal, Cpe, Che, Phe-Pro, dHis-Pro, dlle, Trp-Leu, and Trp-dVal.

[0058] In some embodiments, the non-naturally occurring melanocortin analog comprises a sequence of Formula (I), wherein:X1is absent, D-valine (dVal), or norleucine (Nle);X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of aspartic acid (Asp), Nle, D- norleucine (dNIe), hisitdine (His), D-histidine (dHis), D-phenylalanine (dPhe), arginine (Arg), D-arginine (dArg) and D-proline (dPro);R2is selected from the group consisting of Asp, proline (Pro), lysine (Lys), cysteine (Cys), D-cysteine (dCys), D-penicillamine (dPen), penicillamine (Pen), glutamic acid (Glu), and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, dPro, tryptyl-proline (Trp-Pro), tryptyl-D-leucine (Trp-dLeu), trytpyl-D-valine (Trp-dVal), D-isoleucine (dlle), D--19-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO alanine (dAla), D-methionine (dMet), glycine (Gly), glycyl-glycine (Gly-Gly), beta-alanine (p-Ala), 3-aminomethyl-benzoic acid (Mamb), 1 -amino-1 -cyclopentane carboxylic (Cpe), 1 - amino-1 -cyclohexanecarboxylic acid (Che), 1 -aminocyclo-propane-1 -carboxylic acid (Acpc), prolyl-proline (Pro-Pro), prolyl-hisitdine (Pro-His), phenylalanyl-proline (Phe-Pro), D-histidyl-proline (dHis-Pro), hydroxyproline (Hyp), prolyl-glutamic acid (Pro-Glu), glutamic acid-histidine (Glu-His), Arg, dPhe, biphenylalanine (Bip), D-biphenylalanine (dBip), D- tyrosine (dTyr), D-tryptophan (dTrp), leucine (Leu), dLeu, dVal, D-glutamine (dGIn), tryptyl- arginine (Trp-Arg), histidyl-arginine (His-Arg), prolyl-arginine (Pro-Arg), arginyl-proline (Arg-Pro), and alanine (Ala);R4is selected from the group consisting of 2’-D-naphthylalanine (dNal(2’)), Bip, dBip, dPhe, para-fluoro-D-phenylalanine (p(F)dPhe), para-chloro-D-phenylalanine (p(CI)dPhe), para-iodo-D-phenylalanine (p(l)dPhe), and para-bromo-D-phenylalanine (p(Br)dPhe);R5is absent or selected from the group consisting of Arg, dArg, D-lysine (dLys), D- ornithine (dOrn), Glu, D-aspartic acid (dAsp), D-glutamic acid (dGlu), Pro, and His;R6is absent or is selected from the group consisting of Trp, tryptyl-glycine (Trp-Gly), tryptyl-proline (Trp-Pro), 2’-naphthylalanine (Nal(2’)), 1 ’-naphthylalanine (Nal(1 ’)), 1 ’-D- naphthylalanine (dNal(1 ’)), Phe, dPhe, and 1 ,2,3,4-tetrahydroisoquinoline carboxylic acid (Tic);R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, dOrn, and ornthine (Orn);Y1is selected from the group consisting of dVal, D-tert-leucine (dTle), dLys, Asp, D- threonine (dThr), p2-valine (p2Val), p3-valine (p3Val), Nle, Trp, dArg, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, p-proline (pPro), Nle, and valine (Vai);Y3is absent or selected from the group consisting of dVal, dThr, dPro, and Pro;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R1or R2and R7when R1or R2is Asp or CO-cis- CH=CH-CO and R7is Lys or dOrn,-20-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that the non-naturally occurring melanocortin analog does not comprise a sequence selected from the group consisting of:Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-Arg-NH2(SEQ ID NO: 6);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Asp-dPro-NH2(SEQ ID NO: 7);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dPro-NH2(SEQ ID NO: 3);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Asp-NH2(SEQ ID NO: 8);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 9);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Lys-dPro-dVal-NH2(SEQ ID NO: 10);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dLys-dPro-dVal-NH2(SEQ ID NO: 11 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Lys-dPro-NH2(SEQ ID NO: 12);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Lys-Val-Pro-NH2(SEQ ID NO: 13);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Lys-dVal-dPro-NH2(SEQ ID NO: 14);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dPro-dVal-NH2(SEQ ID NO: 15);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dVal-dPro-NH2(SEQ ID NO: 16);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 17);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dVal-NH2(SEQ ID NO: 18);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dTle-NH2(SEQ ID NO: 19);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dTle-dPro-NH2(SEQ ID NO: 20);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 21 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dPro-dTle-NH2(SEQ ID NO: 22);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dTle-NH2(SEQ ID NO: 23);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 24);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-dVal-dPro-NH2(SEQ ID NO: 25);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Trp-NH2(SEQ ID NO: 26);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dTle-dPro-NH2(SEQ ID NO: 27);-21 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dVal-NH2(SEQ ID NO: 28);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-NH2(SEQ ID NO: 29);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dLys-dPro-NH2(SEQ ID NO: 30);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dLys-dVal-dPro-NH2(SEQ ID NO: 31 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dVal-dPro-NH2(SEQ ID NO: 32);Ac-Nle-c[Asp-His-dNal(2')-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 33);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Asp-dVal-dPro-NH2(SEQ ID NO: 34);Ac-Nle-c[Asp-Pro-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 35);Ac-Nle-c[Asp-Pro-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 36);Ac-Nle-c[Asp-Pro-dNal(2')-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 37);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Nal(1 ’)-Lys]-dVal-dPro-NH2(SEQ ID NO: 38);Ac-Nle-c[Asp-Hyp-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 39);Ac-Nle-c[Asp-Hyp-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 40);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Phe-Lys]-dVal-dPro-NH2(SEQ ID NO: 41 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-dPhe-Lys]-dVal-dPro-NH2(SEQ ID NO: 42);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-dNal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 43);Ac-Nle-c[Asp-His-dNal(2')-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 44);Ac-dVal-dPro-c[Lys-Trp-Arg-dNal(2')-His-Asp]-Nle-Nle-NH2(SEQ ID NO: 45);Ac-dVal-dPro-c[Asp-Trp-Arg-dNal(2')-His-Lys]-Nle-Nle-NH2(SEQ ID NO: 46);Ac-Nle-c[Asp-His-dNal(2')-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 47);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Nal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 48);Ac-Arg-c[Glu-Pro-His-dNal(2')-His-Trp-Orn]-dVal-dPro-NH2(SEQ ID NO: 49);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dPro-NH2(SEQ ID NO: 3);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-dCys]-dArg-dPro-NH2(SEQ ID NO: 50);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 51 );Ac-His-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 52);Ac-dHis-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 53);Ac-Nle-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 54);Ac-Nle-c[Asp-Pro-p(F)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 55);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 56);Ac-Nle-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 57);-22-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-dArg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 58);Ac-Arg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 59);Ac-His-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 60);Ac-dHis-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 61 );Ac-Nle-c[Cys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 62);Ac-Nle-c[dCys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 63);Ac-Nle-c[dCys-His-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 64);Ac-dArg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 65);Ac-Arg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 66);Ac-His-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 67);Ac-dHis-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 68);Ac-Nle-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 69);Ac-Nle-c[Asp-His-p(F)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 70);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 71 );Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 72);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 73);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 74);Ac-Nle-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 75);Ac-dArg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 76);Ac-Arg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 77);Ac-His-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 78);Ac-dHis-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 79);Ac-Nle-c[Cys-Pro-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 80);Ac-Nle-c[dCys-Pro-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 81 );Ac-Nle-c[dCys-Pro-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 82);Ac-dArg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 83);Ac-Arg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 84);Ac-Nle-c[Asp-Bip-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 85);Ac-Nle-c[Asp-dGln-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 86);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 87);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Orn]-dVal-dPro-NH2 (SEQ ID NO: 88);-23-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Trp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 89); c[CO-cis-CH=CH-CO-Pro-p(F)dPhe-Arg-Trp-l_ys]-dVal-dPro-NH2(SEQ ID NO: 90); c[CO-cis-CH=CH-CO-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 91 );Ac-Nle-c[Asp-[3-Ala-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 92);Ac-Nle-c[Pen-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 93);Ac-Nle-c[Asp-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 94);Ac-Nle-c[Asp-Mamb-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 95);Ac-Nle-c[Asp-His-p(F)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 96);Ac-Nle-c[Asp-Pro-p(F)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 97);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 98);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 99);Ac-dVal-dPro-c[Lys-Trp-Arg-p(F)dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 100);Ac-dVal-dPro-c[Asp-Trp-Arg-p(F)dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 101 );Ac-dVal-dPro-c[Lys-Trp-Arg-p(F)dPhe-His-Asp]-Nle-Nle-NH2(SEQ ID NO: 102);Ac-dVal-dPro-c[Asp-Trp-Arg-p(F)dPhe-His-Lys]-Nle-Nle-NH2(SEQ ID NO: 103);Ac-Nle-c[Asp-Pro-d(F);Phe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 104);Ac-Nle-c[Asp-Pro-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 105);Ac-dPhe-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 106);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 107);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 108);Ac-Nle-c[Pen-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 93);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 109);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 110);Ac-Nle-c[Cys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 111 );Ac-Nle-c[dCys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 112);Ac-Nle-c[dCys-His-p(CI)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 113);Ac-Arg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 114);Ac-His-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 115);Ac-dHis-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 1 16);Ac-Nle-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 117);Ac-Nle-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 118);-24-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-His-p(CI)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 1 19);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 120);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 121 );Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 122);Ac-Nle-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 123);Ac-dArg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 124);Ac-Arg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 125);Ac-His-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 126);Ac-dHis-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 127);Ac-Nle-c[Asp-dGln-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 128);Ac-Nle-c[Asp-dTrp-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 129);Ac-Nle-c[Asp-Bip-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 130);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Orn]-dVal-dPro-NH2(SEQ ID NO: 131 );Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-NH2(SEQ ID NO: 132); c[CO-cis-CH=CH-CO-Pro-p(CI)dPhe-Arg-Trp-l_ys]-dVal-dPro-NH2(SEQ ID NO: 133);Ac-Nle-c[Asp-Pro-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 134);Ac-Nle-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 118);Ac-Arg-c[Asp-Pro-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 135);Ac-Arg-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 136);Ac-Nle-c[Asp-Trp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 137); c[CO-cis-CH=CH-CO-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 138);Ac-Nle-c[Asp-[3-Ala-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 139);Ac-Nle-c[Pen-p(CI)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 140);Ac-Nle-c[Asp-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 141 );Ac-Nle-c[Asp-Mamb-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 142);Ac-Nle-c[Asp-His-p(CI)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 143);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 144);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 145);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 146);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 147);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 148);-25-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-dVal-dPro-c[Lys-Trp-Arg-p(CI)dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 149);Ac-dVal-dPro-c[Asp-Trp-Arg-p(CI)dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 150);Ac-dVal-dPro-c[Lys-Trp-Arg-p(CI)dPhe-His-Asp]-Nle-Nle-NH2(SEQ ID NO: 151 );Ac-dVal-dPro-c[Asp-Trp-Arg-p(CI)dPhe-His-Lys]-Nle-Nle-NH2(SEQ ID NO: 152);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 153);Ac-Nle-c[Asp-Pro-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 154);Ac-Nle-c[Cys-His-p(Br)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 155);Ac-dArg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 156);Ac-Arg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 157);Ac-His-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 158);Ac-dHis-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 159);Ac-Nle-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 160);Ac-Nle-c[Asp-His-p(Br)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 161 );Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 162);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 163);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 164);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 165);Ac-Nle-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 166);Ac-dArg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 167);Ac-Arg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 168);Ac-Nle-c[Asp-dBip-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 169);Ac-Nle-c[Asp-Pro-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 170);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 171 );Ac-Nle-c[Asp-His-Arg-p(l)dPhe-Arg-Tic-Lys]-dVal-dPro-NH2(SEQ ID NO: 172);Ac-Nle-c[Asp-Pro-Arg-p(l)dPhe-Arg-Tic-Lys]-dVal-dPro-NH2(SEQ ID NO: 173);Ac-Nle-c[Asp-Pro-p(l)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 174);Ac-Nle-c[Asp-His-p(l)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 175);Ac-Nle-c[Asp-Pro-dBip-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 176);Ac-Nle-c[Lys-His-Arg-dBip-Arg-Tic-Asp]-dVal-dPro-NH2(SEQ ID NO: 177);Ac-Nle-c[Lys-Pro-Arg-dBip-Arg-Tic-Asp]-dVal-dPro-NH2(SEQ ID NO: 178);Ac-dArg-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 179);-26-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-dNle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 180);Ac-dPro-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 181 );Ac-Nle-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 182);Ac-Nle-Nle-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 183);Ac-dVal-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 184);Ac-dNle-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 185);Ac-dArg-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 186);Ac-Arg-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 187);Ac-dHis-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 188);Ac-His-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 189);Ac-Asp-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 190);Ac-Arg-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 191 );Ac-His-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 192);Ac-dHis-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 193);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 194);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 195);Ac-dPhe-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 196);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dVal-dPro-NH2(SEQ ID NO: 197);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 198);Ac-Nle-c[Asp-Pro-dNal(2')-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 199);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Gly-Lys]-dVal-dPro-NH2(SEQ ID NO: 200);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 201 );Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 202);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 203);Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 204);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 205);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 206);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 207);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 208);Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 209);Ac-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 210);-27-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Pro-dNal(2')-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 211 );Ac-Nle-c[Asp-Ala-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 212);Ac-Nle-c[Asp-Gly-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 213);Ac-Nle-c[Asp-Leu-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 214);Ac-dPhe-c[Asp-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 215); c[CO-cis-CH=CH-CO-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 216);Ac-Nle-c[dCys-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 217);Ac-Nle-c[Cys-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 218);Ac-Nle-c[Asp-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 219);Ac-Nle-c[Asp-Glu-His-dNal(2')-Arg-Trp-Gly-Lys]-dVal-dPro-NH2(SEQ ID NO: 220);Ac-Nle-c[Asp-Pro-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 221 );Ac-Nle-c[dPen-Pro-dPhe-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 222);Ac-Nle-c[dCys-Pro-dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 223);Ac-Nle-c[Asp-Pro-dPhe-Arg-Nal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 224);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dThr-dPro-dThr-OH (SEQ ID NO: 225);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 226);His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 227); dPhe-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 228); dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 229);Ac-Nle-c[Asp-Pro-dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 230);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 231 );Ac-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 232);Ac-dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 233);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dArg-dVal-dPro-NH2(SEQ ID NO: 234);Ac-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dLys-dPro-NH2(SEQ ID NO: 235);Ac-Nle-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 236);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dArg-dPro-NH2(SEQ ID NO: 237);Ac-dArg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 238);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 239);Ac-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 240);Ac-dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 241 );-28-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dArg-NH2 (SEQ ID NO: 242);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dVal-dPro-NH2 (SEQ ID NO: 243);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dLys-dVal-dPro-NH2 (SEQ ID NO: 244);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dArg-dVal-dPro-NH2 (SEQ ID NO: 245);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 246);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dTle-dPro-NH2 (SEQ ID NO: 247);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 248);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dTle-NH2(SEQ ID NO: 249);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dPro-NH2(SEQ ID NO: 250);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 251 );Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-dVal-dPro-NH2(SEQ ID NO: 252);Ac-dArg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 253);Ac-Nle-Nle-Nle-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 254);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Trp-NH2 (SEQ ID NO: 255);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Gly-Lys]-dVal-dPro-NH2(SEQ ID NO: 256);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dPro-dVal-NH2 (SEQ ID NO: 257);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dPro-NH2 (SEQ ID NO: 258);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 4);Ac-Nle-c[dCys-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 259);Ac-Nle-c[Asp-Pro-dPhe-Arg-Phe-Lys]-dVal-dPro-NH2(SEQ ID NO: 261 );Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 262); c[CO-cis-CH=CH-CO-Pro-dPhe-Arg-Trp-l_ys]-dVal-dPro-NH2(SEQ ID NO: 263);Ac-Asp-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 264);Ac-dVal-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 265);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 266);Ac-Nle-c[Asp-Pro-dPhe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 267);Ac-Nle-c[Asp-dPhe-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 268);Ac-Nle-c[Asp-dTyr-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 269);Ac-Nle-c[Asp-dGln-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 270);Ac-Nle-c[Asp-dTrp-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 271 );Ac-Nle-c[Asp-Bip-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 272);-29-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Leu-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 273);Ac-dHis-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 274);Ac-His-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 275);Ac-Nle-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 276);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dArg-dVal-dPro-NH2 (SEQ ID NO: 277);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dLys-dVal-dPro-NH2 (SEQ ID NO: 278);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dArg-dPro-NH2 (SEQ ID NO: 279);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dLys-dPro-NH2 (SEQ ID NO: 280);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 281 );Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 282);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 283);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 284);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Pro-Lys]-dVal-dPro-NH2 (SEQ ID NO: 285);Ac-Nle-c[dPen-dPhe-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 286);Ac-Nle-c[Asp-Hyp-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 287);Ac-Nle-c[Asp-Pro-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 288);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 289);Ac-Nle-c[Cys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2 (SEQ ID NO: 290);Ac-Nle-c[dCys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2 (SEQ ID NO: 291 );Ac-Arg-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 292);Ac-dArg-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 293);Ac-Asp-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 294);Ac-His-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 295);Ac-Nle-c[Asp-Gly-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 296);Ac-Nle-c[Asp-dLeu-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 297);Ac-Nle-c[Asp-dMet-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 298); c[CO-cis-CH=CH-CO-His-dPhe-Arg-Trp-l_ys]-dVal-dPro-NH2(SEQ ID NO: 299);Ac-Nle-c[Asp-p-Ala-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 300);Ac-Nle-c[Asp-Mamb-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 301 );Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dArg-NH2 (SEQ ID NO: 302);Ac-dVal-dPro-c[Lys-Trp-Arg-dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 303);-30-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-dVal-dPro-c[Asp-Trp-Arg-dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 304); Ac-dVal-dPro-c[Lys-Trp-Arg-dPhe-His-Asp]-Nle-Nle-NH2(SEQ ID NO: 305); Ac-dVal-dPro-c[Asp-Trp-Arg-dPhe-His-Lys]-Nle-Nle-NH2(SEQ ID NO: 306); Ac-Arg-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 307); Ac-Nle-c[Asp-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 308); Ac-Arg-c[Asp-Pro-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 309); Ac-Arg-c[Asp-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 310); Ac-Nle-c[Asp-dAla-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 311 ); Ac-Nle-c[Pen-dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 312);Ac-Nle-c[Asp-His-dPhe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 313);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 314); and Ac-Arg-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 315), wherein c represents cyclization via a lactam or disulfide bond.

[0059] In some embodiments, the non-naturally occurring melanocortin analog is selective for the melanocortin 4 receptor and / or melanocortin 3 receptor over other melanocortin receptors. For example, the melanocortin analog may only bind the melanocortin 4 receptor, may selectively bind the melanocortin 4 receptor, may bind the melanocortin 4 receptor with substantially higher affinity that other melanocortin receptors. Alternatively, or additionally, the melanocortin analog may only bind the melanocortin 3 receptor, may selectively bind the melanocortin 3 receptor, may bind the melanocortin 3 receptor with substantially higher affinity that other melanocortin receptors Accordingly, in some embodiments, the sequence of Formula (I) is a sequence of Formula (IA):X1-X2-X3- R1- R2- R3- R4- R5- R6-R7-Y1-Y2-Y3-Y4( I A) , wherein:X1is absent, dVal, or Nle;X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of Asp, Nle, dNIe, His, dHis, dPhe, Arg, dPro, and dArg;-31 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOR2is selected from the group consisting of Asp, Pro, Lys, Cys, dCys, dPen, Pen, Glu and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, Trp-Pro, dAla, dMet, Gly, Gly-Gly, p-Ala, Mamb, Cpe, Che, Pro-Pro, Pro-His, Pro-Glu, Arg, dPhe, dBip, dTyr, Leu, dLeu, dVal, Trp-Arg, and Ala;R4is selected from the group consisting of dNal(2’), dPhe, p(F)dPhe, p(CI)dPhe, and p(Br)dPhe;R5is absent or selected from the group consisting of Arg, dLys, dArg, dOrn, Glu, dAsp, dGlu, Pro, and His;R6is absent or is selected from the group consisting of Trp, Trp-Gly, Trp-Pro, Nal(2’), and Nal(T);R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, dOrn, and Orn;Y1is selected from the group consisting of dVal, dTle, dLys, Asp, dThr, p2Val, p3Val, Nle, Trp, dArg, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, pPro, Nle, and Vai;Y3is absent or selected from the group consisting of dVal, dThr, dPro, and Pro;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R1or R2and R7when R1or R2is Asp or CO-cis- CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that:-32-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO when R4is dNal(2’), then R3is not Pro-His or Pro-Pro, R1is not dArg, R5is not His, R6is not Phe, dPhe, Nal (1 ’), or dNal(1 ’), and either (i) Y1is dVal, Y2is dPro, and Y3-Y4are absent (ii) Y1is dLys or dArg, and R2is dPen, (iii) Y1is Nle, Y2is absent, and R2is Lys, or (iv) Y1is Nle, Y2is Nle, and R2is Asp, when R4is p(F)dPhe, then R3is Pro, and either (i) R6is not Trp or (ii) Y1and Y2are each independently dVal or dTle, when R4is p(CI)dPhe, then R3is His, R1is dArg, and Y1is dVal, when R4is p(Br)dPhe, then R3is dTyr or His, wherein when R3is His then either (i) R1is His or dHis and Y1is dTle or (ii) R2is dCys and R7is Cys, when R4is dNal(2’) and R3is Pro, then R1is absent, dPhe, or Nle and R6is Trp, wherein when R1is absent, then R2is CO-cis-CH=CH-CO, when R1is dPhe, then R2is dPen, and when R1is Nle, then (i) R2is Asp and either (a) R5is not Arg, Pro, or absent, (b) R7is not Lys, or (c) X1-X3are all Nle, (ii) R2and R7are each is dPen or (iii) R2is Pen or Cys, and R7is dCys, when R4is dNal(2’) and R3is Ala, Leu, dLeu, dVal, Gly, or His, then either R2is dPen or R6is Trp-Pro, when R4is dNal(2’) and R3is absent, then (i) R2is not Asp, (ii) R2and R7are not both Cys, and (iii) when R2is dCys, then R7is dCys, when R4is dPhe and R3is Pro, then the N-terminus is acetylated, X1-X2are each independently absent or Nle, X3is absent, R1is dNIe, dPhe or Nle, R2is Cys or Asp, R5is Arg or Pro, R6is Trp or dNal(T), the C-terminus is amidated, wherein when R1is Nle, then either (i) Y1is dVal, Y2is dPro and at least one of X1-X2is Nle, (ii) Y1is dVal or Lys and Y2is dArg or Vai, or (iii) Y1is dLys, Asp, dThr, p2Val, or p3Val, and Y2is not dVal, and when R4is dPhe, and R3is not Pro, then the N-terminus is acetylated, X1-X3are absent, R1is absent, Nle, Arg, or dArg, Y1is dVal, Y2is dPro and Y3-Y4are absent, and either (i) R3is absent and R7is Cys, (ii) R3is Trp-Pro and either R5is His, or R6is Nal(1 ’), (iii) R3is Pro-His, R1is Nle and R5is His, (iv) R3is dAla and R1is Arg, or (vi) R3is selected from dBip, Pro-Pro, and Arg.

[0060] In some embodiments, the non-naturally occurring melanocortin analog comprises a sequence of Formula (IA):-33-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOX1-X2-X3- R1- R2- R3- R4- R5- R6-R7-Y1-Y2-Y3-Y4( I A) , wherein:X1is absent, dVal, or Nle;X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of Asp, Nle, dNIe, His, dHis, dPhe, Arg, dPro, and dArg;R2is selected from the group consisting of Asp, Pro, Lys, Cys, dCys, dPen, Pen, Glu and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, Trp-Pro, dAla, dMet, Gly, Gly-Gly, p-Ala, Mamb, Cpe, Che, Pro-Pro, Pro-His, Pro-Glu, Arg, dPhe, dBip, dTyr, Leu, dLeu, dVal, Trp-Arg, and Ala;R4is selected from the group consisting of dNal(2’), dPhe, p(F)dPhe, p(CI)dPhe, and p(Br)dPhe;R5is absent or selected from the group consisting of Arg, dLys, dArg, dOrn, Glu, dAsp, dGlu, Pro, and His;R6is absent or is selected from the group consisting of Trp, Trp-Gly, Trp-Pro, Nal(2’), and Nal(T);R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, dOrn, and Orn;Y1is selected from the group consisting of dVal, dTle, dLys, Asp, dThr, p2Val, p3Val, Nle, Trp, dArg, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, pPro, Nle, and Vai;Y3is absent or selected from the group consisting of dVal, dThr, dPro, and Pro;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R1or R2and R7when R1or R2is Asp or CO-cis- CH=CH-CO and R7is Lys or dOrn,-34-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that: when R4is dNal(2’), then R3is not Pro-His or Pro-Pro, R1is not dArg, R5is not His, R6is not Phe, dPhe, Nal (1 ’), or dNal(1 ’), and either (i) Y1is dVal, Y2is dPro, and Y3-Y4are absent (ii) Y1is dLys or dArg, and R2is dPen, (iii) Y1is Nle, Y2is absent, and R2is Lys, or (iv) Y1is Nle, Y2is Nle, and R2is Asp, when R4is p(F)dPhe, then R3is Pro, and either (i) R6is not Trp or (ii) Y1and Y2are each independently dVal or dTle, when R4is p(CI)dPhe, then R3is His, R1is dArg, and Y1is dVal, when R4is p(Br)dPhe, then R3is dTyr or His, wherein when R3is His then either (i) R1is His or dHis and Y1is dTle or (ii) R2is dCys and R7is Cys, when R4is dNal(2’) and R3is Pro, then R1is absent, dPhe, or Nle and R6is Trp, wherein when R1is absent, then R2is CO-cis-CH=CH-CO, when R1is dPhe, then R2is dPen, and when R1is Nle, then (i) R2is Asp and either (a) R5is not Arg, Pro, or absent, (b) R7is not Lys, or (c) X1-X3are all Nle, (ii) R2and R7are each is dPen or (iii) R2is Pen or Cys, and R7is dCys, when R4is dNal(2’) and R3is Ala, Leu, dLeu, dVal, Gly, or His, then either R2is dPen or R6is Trp-Pro, when R4is dNal(2’) and R3is absent, then (i) R2is not Asp, (ii) R2and R7are not both Cys, and (iii) when R2is dCys, then R7is dCys, when R4is dPhe and R3is Pro, then the N-terminus is acetylated, X1-X2are each independently absent or Nle, X3is absent, R1is dNIe, dPhe or Nle, R2is Cys or Asp, R5is Arg or Pro, R6is Trp or dNal(T), the C-terminus is amidated, wherein when R1is Nle, then either (i) Y1is dVal, Y2is dPro and at least one of X1-X2is Nle, (ii) Y1is dVal or Lys and Y2is dArg or Vai, or (iii) Y1is dLys, Asp, dThr, p2Val, or p3Val, and Y2is not dVal, and-35-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO when R4is dPhe, and R3is not Pro, then the N-terminus is acetylated, X1-X3are absent, R1is absent, Nle, Arg, or dArg, Y1is dVal, Y2is dPro and Y3-Y4are absent, and either (i) R3is absent and R7is Cys, (ii) R3is Trp-Pro and either R5is His, or R6is Nal(1 ’), (iii) R3is Pro-His, R1is Nle and R5is His, (iv) R3is dAla and R1is Arg, or (vi) R3is selected from dBip, Pro-Pro, and Arg.

[0061] In some embodiments, the non-naturally occurring melanocortin analog comprises a sequence of Formula (IA), wherein:X1is absent, dVal, or Nle;X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of Asp, Nle, dNIe, His, dHis, dPhe, Arg, dPro, and dArg;R2is selected from the group consisting of Asp, Pro, Lys, Cys, dCys, dPen, Pen, Glu and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, Trp-Pro, dAla, dMet, Gly, Gly-Gly, p-Ala, Mamb, Cpe, Che, Pro-Pro, Pro-His, Pro-Glu, Arg, dPhe, dBip, dTyr, Leu, dLeu, dVal, Trp-Arg, and Ala;R4is selected from the group consisting of dNal(2’), dPhe, p(F)dPhe, p(CI)dPhe, and p(Br)dPhe;R5is absent or selected from the group consisting of Arg, dLys, dArg, dOrn, Glu, dAsp, dGlu, Pro, and His;R6is absent or is selected from the group consisting of Trp, Trp-Gly, Trp-Pro, Nal(2’), and Nal(T);R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, dOrn, and Orn;Y1is selected from the group consisting of dVal, dTle, dLys, Asp, dThr, p2Val, p3Val, Nle, Trp, dArg, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, pPro, Nle, and Vai;Y3is absent or selected from the group consisting of dVal, dThr, dPro, and Pro;Y4is absent or dPro; and-36-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R1or R2and R7when R1or R2is Asp or CO-cis-CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that the non-naturally occurring melanocortin analog does not comprise a sequence selected from the group consisting of:Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-Arg-NH2(SEQ ID NO: 6);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Asp-dPro-NH2(SEQ ID NO: 7);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dPro-NH2(SEQ ID NO: 3);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Asp-NH2(SEQ ID NO: 8);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 9);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Lys-dPro-dVal-NH2(SEQ ID NO: 10);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dLys-dPro-dVal-NH2(SEQ ID NO: 11 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Lys-dPro-NH2(SEQ ID NO: 12);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Lys-Val-Pro-NH2(SEQ ID NO: 13);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Lys-dVal-dPro-NH2(SEQ ID NO: 14);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dPro-dVal-NH2(SEQ ID NO: 15);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dVal-dPro-NH2(SEQ ID NO: 16);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 17);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dVal-NH2(SEQ ID NO: 18);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dTle-NH2(SEQ ID NO: 19);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dTle-dPro-NH2(SEQ ID NO: 20);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 21 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dPro-dTle-NH2(SEQ ID NO: 22);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dTle-NH2(SEQ ID NO: 23);-37-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 24);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-dVal-dPro-NH2(SEQ ID NO: 25);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Trp-NH2(SEQ ID NO: 26);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dTle-dPro-NH2(SEQ ID NO: 27);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dVal-NH2(SEQ ID NO: 28);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-NH2(SEQ ID NO: 29);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dLys-dPro-NH2(SEQ ID NO: 30);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dLys-dVal-dPro-NH2(SEQ ID NO: 31 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dVal-dPro-NH2(SEQ ID NO: 32);Ac-Nle-c[Asp-His-dNal(2')-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 33);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Asp-dVal-dPro-NH2(SEQ ID NO: 34);Ac-Nle-c[Asp-Pro-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 35);Ac-Nle-c[Asp-Pro-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 36);Ac-Nle-c[Asp-Pro-dNal(2')-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 211 );Ac-Nle-c[Asp-Pro-dNal(2')-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 37);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Nal(1 ’)-Lys]-dVal-dPro-NH2(SEQ ID NO: 38);Ac-dVal-dPro-c[Lys-Trp-Arg-dNal(2')-His-Asp]-Nle-Nle-NH2(SEQ ID NO: 45);Ac-dVal-dPro-c[Asp-Trp-Arg-dNal(2')-His-Lys]-Nle-Nle-NH2(SEQ ID NO: 46);Ac-Nle-c[Asp-His-dNal(2')-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 44);Ac-Nle-c[Asp-His-dNal(2')-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 47);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Nal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 48);Ac-Arg-c[Glu-Pro-His-dNal(2')-His-Trp-Orn]-dVal-dPro-NH2(SEQ ID NO: 49);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dPro-NH2(SEQ ID NO: 3);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-dCys]-dArg-dPro-NH2(SEQ ID NO: 50);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 51 );Ac-His-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 52);Ac-dHis-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 53);Ac-Nle-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 54);Ac-Nle-c[Asp-Pro-p(F)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 55);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 56);Ac-Nle-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 57);-38-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-dArg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 58);Ac-Arg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 59);Ac-His-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 60);Ac-dHis-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 61 );Ac-Nle-c[Cys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 62);Ac-Nle-c[dCys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 63);Ac-Nle-c[dCys-His-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 64);Ac-dArg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 65);Ac-Arg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 66);Ac-His-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 67);Ac-dHis-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 68);Ac-Nle-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 69);Ac-Nle-c[Asp-His-p(F)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 70);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 71 );Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 72);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 73);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 74);Ac-Nle-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 75);Ac-dArg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 76);Ac-Arg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 77);Ac-His-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 78);Ac-dHis-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 79);Ac-Nle-c[Cys-Pro-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 80);Ac-Nle-c[dCys-Pro-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 81 );Ac-Nle-c[dCys-Pro-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 82);Ac-dArg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 83);Ac-Arg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 84);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 87);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Orn]-dVal-dPro-NH2 (SEQ ID NO: 88);Ac-Nle-c[Asp-Trp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 89); c[CO-cis-CH=CH-CO-Pro-p(F)dPhe-Arg-Trp-l_ys]-dVal-dPro-NH2(SEQ ID NO: 90);-39-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO c[CO-cis-CH=CH-CO-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 91 );Ac-Nle-c[Asp-p-Ala-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 92);Ac-Nle-c[Pen-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 93);Ac-Nle-c[Asp-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 94);Ac-Nle-c[Asp-Mamb-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 95);Ac-Nle-c[Asp-His-p(F)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 96);Ac-Nle-c[Asp-Pro-p(F)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 97);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 98);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 99);Ac-dVal-dPro-c[Lys-Trp-Arg-p(F)dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 100);Ac-dVal-dPro-c[Asp-Trp-Arg-p(F)dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 101 );Ac-dVal-dPro-c[Lys-Trp-Arg-p(F)dPhe-His-Asp]-Nle-Nle-NH2(SEQ ID NO: 102);Ac-dVal-dPro-c[Asp-Trp-Arg-p(F)dPhe-His-Lys]-Nle-Nle-NH2(SEQ ID NO: 103);Ac-Nle-c[Asp-Pro-d(F);Phe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 104);Ac-Nle-c[Asp-Pro-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 105);Ac-dPhe-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 106);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 107);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 108);Ac-Nle-c[Pen-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 93);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 109);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 110);Ac-Nle-c[Cys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 111 );Ac-Nle-c[dCys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 112);Ac-Nle-c[dCys-His-p(CI)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 113);Ac-Arg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 114);Ac-His-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 115);Ac-dHis-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 1 16);Ac-Nle-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 117);Ac-Nle-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 118);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 1 19);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 120);-40-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 121 );Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 122);Ac-Nle-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 123);Ac-dArg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 124);Ac-Arg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 125);Ac-His-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 126);Ac-dHis-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 127);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Orn]-dVal-dPro-NH2(SEQ ID NO: 131 );Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-NH2(SEQ ID NO: 132); c[CO-cis-CH=CH-CO-Pro-p(CI)dPhe-Arg-Trp-l_ys]-dVal-dPro-NH2(SEQ ID NO: 133);Ac-Nle-c[Asp-Pro-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 134);Ac-Nle-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 118);Ac-Arg-c[Asp-Pro-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 135);Ac-Arg-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 136);Ac-Nle-c[Asp-Trp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 137); c[CO-cis-CH=CH-CO-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 138);Ac-Nle-c[Asp-[3-Ala-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 139);Ac-Nle-c[Pen-p(CI)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 140);Ac-Nle-c[Asp-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 141 );Ac-Nle-c[Asp-Mamb-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 142);Ac-Nle-c[Asp-His-p(CI)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 143);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 144);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 145);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 146);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 147);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 148);Ac-dVal-dPro-c[Lys-Trp-Arg-p(CI)dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 149);Ac-dVal-dPro-c[Asp-Trp-Arg-p(CI)dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 150);Ac-dVal-dPro-c[Lys-Trp-Arg-p(CI)dPhe-His-Asp]-Nle-Nle-NH2(SEQ ID NO: 151 );Ac-dVal-dPro-c[Asp-Trp-Arg-p(CI)dPhe-His-Lys]-Nle-Nle-NH2(SEQ ID NO: 152);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 153);-41 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Pro-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 154);Ac-Nle-c[Cys-His-p(Br)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 155);Ac-dArg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 156);Ac-Arg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 157);Ac-His-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 158);Ac-dHis-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 159);Ac-Nle-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 160);Ac-Nle-c[Asp-His-p(Br)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 161 );Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 162);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 163);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 164);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 165);Ac-Nle-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 166);Ac-dArg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 167);Ac-Arg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 168);Ac-Nle-c[Asp-dBip-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 169);Ac-Nle-c[Asp-Pro-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 170);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 171 );Ac-dArg-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 179);Ac-dNle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 180);Ac-dPro-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 181 );Ac-Nle-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 182);Ac-Nle-Nle-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 183);Ac-dVal-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 184);Ac-dNle-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 185);Ac-dArg-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2 (SEQ ID NO: 186);Ac-Arg-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 187);Ac-dHis-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 188);Ac-His-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 189);Ac-Asp-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 190);Ac-Arg-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 191 );-42-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-His-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 192);Ac-dHis-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 193);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 194);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 195);Ac-dPhe-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 196);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dVal-dPro-NH2(SEQ ID NO: 197);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 198);Ac-Nle-c[Asp-Pro-dNal(2')-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 199);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Gly-Lys]-dVal-dPro-NH2(SEQ ID NO: 200);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 201 );Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 202);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 203);Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 204);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 205);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 206);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 207);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 208);Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 209);Ac-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 210);Ac-Nle-c[Asp-Ala-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 212);Ac-Nle-c[Asp-Gly-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 213);Ac-Nle-c[Asp-Leu-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 214);Ac-dPhe-c[Asp-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 215); c[CO-cis-CH=CH-CO-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 216);Ac-Nle-c[dCys-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 217);Ac-Nle-c[Cys-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 218);Ac-Nle-c[Asp-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 219);Ac-Nle-c[Asp-Pro-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 221 );Ac-Nle-c[dPen-Pro-dPhe-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 222);Ac-Nle-c[dCys-Pro-dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 223);Ac-Nle-c[Asp-Pro-dPhe-Arg-Nal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 224);-43-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dThr-dPro-dThr-OH (SEQ ID NO: 225);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 226);His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 227); dPhe-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 228); dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 229);Ac-Nle-c[Asp-Pro-dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 230);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 231 );Ac-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 232);Ac-dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 233);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dArg-dVal-dPro-NH2(SEQ ID NO: 234);Ac-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dLys-dPro-NH2(SEQ ID NO: 235);Ac-Nle-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 236);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dArg-dPro-NH2(SEQ ID NO: 237);Ac-dArg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 238);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 239);Ac-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 240);Ac-dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 241 );Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 242);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dVal-dPro-NH2(SEQ ID NO: 243);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dLys-dVal-dPro-NH2(SEQ ID NO: 244);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dArg-dVal-dPro-NH2(SEQ ID NO: 245);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 246);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dTle-dPro-NH2(SEQ ID NO: 247);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 248);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dTle-NH2(SEQ ID NO: 249);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dPro-NH2(SEQ ID NO: 250);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 251 );Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-dVal-dPro-NH2(SEQ ID NO: 252);Ac-dArg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 253);Ac-Nle-Nle-Nle-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 254);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Trp-NH2(SEQ ID NO: 255);-44-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Pro-dPhe-Arg-Trp-Gly-Lys]-dVal-dPro-NH2(SEQ ID NO: 256);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dPro-dVal-NH2 (SEQ ID NO: 257);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dPro-NH2 (SEQ ID NO: 258);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 4);Ac-Nle-c[dCys-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 259);Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 262); c[CO-cis-CH=CH-CO-Pro-dPhe-Arg-Trp-l_ys]-dVal-dPro-NH2(SEQ ID NO: 263);Ac-Asp-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 264);Ac-dVal-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 265);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 266);Ac-Nle-c[Asp-Pro-dPhe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 267);Ac-Nle-c[Asp-dPhe-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 268);Ac-Nle-c[Asp-dTyr-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 269);Ac-Nle-c[Asp-Leu-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 273);Ac-dHis-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 274);Ac-His-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 275);Ac-Nle-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 276);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dArg-dVal-dPro-NH2 (SEQ ID NO: 277);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dLys-dVal-dPro-NH2 (SEQ ID NO: 278);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dArg-dPro-NH2 (SEQ ID NO: 279);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dLys-dPro-NH2 (SEQ ID NO: 280);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 281 );Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 282);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 283);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 284);Ac-Nle-c[dPen-dPhe-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 286);Ac-Nle-c[Asp-Pro-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 288);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Pro-Lys]-dVal-dPro-NH2 (SEQ ID NO: 285);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 289);Ac-Nle-c[Cys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2 (SEQ ID NO: 290);Ac-Nle-c[dCys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2 (SEQ ID NO: 291 );-45-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Arg-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 292);Ac-dArg-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 293);Ac-Asp-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 294);Ac-His-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 295);Ac-Nle-c[Asp-Gly-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 296);Ac-Nle-c[Asp-dLeu-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 297);Ac-Nle-c[Asp-dMet-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 298); c[CO-cis-CH=CH-CO-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 299);Ac-Nle-c[Asp-p-Ala-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 300);Ac-Nle-c[Asp-Mamb-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 301 );Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dArg-NH2 (SEQ ID NO: 302);Ac-dVal-dPro-c[Lys-Trp-Arg-dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 303);Ac-dVal-dPro-c[Asp-Trp-Arg-dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 304);Ac-dVal-dPro-c[Lys-Trp-Arg-dPhe-His-Asp]-Nle-Nle-NH2(SEQ ID NO: 305);Ac-dVal-dPro-c[Asp-Trp-Arg-dPhe-His-Lys]-Nle-Nle-NH2(SEQ ID NO: 306);Ac-Arg-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 307);Ac-Nle-c[Asp-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 308);Ac-Arg-c[Asp-Pro-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 309);Ac-Arg-c[Asp-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 310);Ac-Nle-c[Asp-dAla-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 311 );Ac-Nle-c[Pen-dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 312);Ac-Nle-c[Asp-His-dPhe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 313);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 314);Ac-Arg-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 315);Ac-Nle-c[Asp-His-dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 316);Ac-Nle-c[Asp-His-dNal(2')-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 317);Ac-dArg-c[Asp-dAla-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 318);Ac-dVal-dPro-c[Asp-Trp-Arg-dNal(2')-Pro-Lys]-Nle-NH2(SEQ ID NO: 319);Ac-dVal-dPro-c[Lys-Trp-Arg-dNal(2')-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 320);Ac-Nle-c[dCys-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 321 );Ac-Nle-c[Asp-dLeu-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 322);-46-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-dVal-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 323);Ac-Nle-c[Asp-dPhe-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 324);Ac-Nle-c[Asp-dBip-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 325);Ac-Nle-c[Asp-dTyr-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 326);Ac-Nle-c[dCys-His-p(Br)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 327);Ac-Nle-c[Asp-dVal-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 328);Ac-Nle-c[Asp-dPhe-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 329);Ac-Nle-c[Asp-dPhe-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 330);Ac-Nle-c[Asp-dBip-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 331 );Ac-Nle-c[Asp-dTyr-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 332);Ac-Nle-c[dCys-Trp-Pro-dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 333);Ac-Nle-c[Asp-Cpe-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 334);Ac-Nle-c[Asp-Che-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 335);Ac-dArg-c[Asp-dAla-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 336); and Ac-Nle-c[Cys-dPhe-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 337), wherein c represents cyclization via a lactam or disulfide bond.

[0062] In some embodiments of the sequence of Formula (I) or (IA), R4is dNal(2’). Accordingly, in some embodiments, the sequence of Formula (I) or (IA) is a sequence of Formula (IA(i)):X1-X2-X3- R1- R2- R3- R4- R5- R6- R7-Y1-Y2-Y3( I A(i)) , wherein:X1is absent, dVal, or Nle;X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of Nle, Arg, dPhe, and dPro;R2is selected from the group consisting of Asp, Lys, Cys, dCys, dPen, Pen, and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, Trp-Pro, dAla, dMet, Gly, Gly-Gly, p-Ala, Mamb, Cpe, Che, Pro-Glu, Leu, dLeu, dVal, Trp-Arg, and Ala;R4is dNal(2’);-47-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOR5is selected from the group consisting of Arg, dLys, dArg, dOrn, Glu, dAsp, dGlu, and Pro;R6is absent or is selected from the group consisting of Trp, Trp-Gly, and Trp-Pro;R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, and dOrn;Y1is selected from the group consisting of dVal, dLys, dArg, and Nle;Y2is absent or selected from dPro, dVal, and Nle;Y3is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R2and R7when R2is Asp or CO-cis-CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that: when R3is Pro, then R1is absent, dPhe, or Nle and R6is Trp, wherein when R1is absent, then R2is CO-cis-CH=CH-CO, when R1is dPhe, then R2is dPen, and when R1is Nle, then (i) R2is Asp and either (a) R5is not Arg, Pro, or absent, (b) R7is not Lys, or (c) X1-X3are all Nle, (ii) R2and R7are each is dPen or (iii) R2is Pen or Cys, and R7is dCys, when R3is Ala, Leu, dLeu, dVal, Gly, or His, then either R2is dPen or R6is Trp-Pro, when R3is absent, then (i) R2is not Asp, (ii) R2and R7are not both Cys, and (iii) when R2is dCys, then R7is dCys, and when R3is Trp-Arg, then Y1is Nle, and either (i) Y2is absent and R2is Lys or (ii) Y2is Nle and R2is Asp.

[0063] In some embodiments, the non-naturally occurring melanocortin analog comprises a sequence of Formula (IA(i)):X1-X2-X3- R1- R2- R3- R4- R5- R6- R7-Y1-Y2-Y3( I A(i)) , wherein:X1is absent, dVal, or Nle;-48-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOX2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of Nle, Arg, dPhe, and dPro;R2is selected from the group consisting of Asp, Lys, Cys, dCys, dPen, Pen, and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, Trp-Pro, dAla, dMet, Gly, Gly-Gly, p-Ala, Mamb, Cpe, Che, Pro-Glu, Leu, dLeu, dVal, Trp-Arg, and Ala;R4is dNal(2’);R5is selected from the group consisting of Arg, dLys, dArg, dOrn, Glu, dAsp, dGlu, and Pro;R6is absent or is selected from the group consisting of Trp, Trp-Gly, and Trp-Pro;R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, and dOrn;Y1is selected from the group consisting of dVal, dLys, dArg, and Nle;Y2is absent or selected from dPro, dVal, and Nle;Y3is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R2and R7when R2is Asp or CO-cis-CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that: when R3is Pro, then R1is absent, dPhe, or Nle and R6is Trp, wherein when R1is absent, then R2is CO-cis-CH=CH-CO, when R1is dPhe, then R2is dPen, and when R1is Nle, then (i) R2is Asp and either (a) R5is not Arg, Pro, or absent, (b) R7is not Lys, or (c) X1-X3are all Nle, (ii) R2and R7are each is dPen or (iii) R2is Pen or Cys, and R7is dCys, when R3is Ala, Leu, dLeu, dVal, Gly, or His, then either R2is dPen or R6is Trp-Pro,-49-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO when R3is absent, then (i) R2is not Asp, (ii) R2and R7are not both Cys, and (iii) when R2is dCys, then R7is dCys, and when R3is Trp-Arg, then Y1is Nle, and either (i) Y2is absent and R2is Lys or (ii) Y2is Nle and R2is Asp.

[0064] In some embodiments, the non-naturally occurring melanocortin analog comprises a sequence of Formula (IA(i)), wherein:X1is absent, dVal, or Nle;X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of Nle, Arg, dPhe, and dPro;R2is selected from the group consisting of Asp, Lys, Cys, dCys, dPen, Pen, and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, Trp-Pro, dAla, dMet, Gly, Gly-Gly, p-Ala, Mamb, Cpe, Che, Pro-Glu, Leu, dLeu, dVal, Trp-Arg, and Ala;R4is dNal(2’);R5is selected from the group consisting of Arg, dLys, dArg, dOrn, Glu, dAsp, dGlu, and Pro;R6is absent or is selected from the group consisting of Trp, Trp-Gly, and Trp-Pro;R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, and dOrn;Y1is selected from the group consisting of dVal, dLys, dArg, and Nle;Y2is absent or selected from dPro, dVal, and Nle;Y3is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R2and R7when R2is Asp or CO-cis-CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, and-50-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that the non-naturally occurring melanocortin analog does not comprise a sequence selected from the group consisting of:Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dVal-NH2(SEQ ID NO: 28);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-NH2(SEQ ID NO: 29);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dLys-dPro-NH2(SEQ ID NO: 30);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dLys-dVal-dPro-NH2(SEQ ID NO: 31 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dVal-dPro-NH2(SEQ ID NO: 32);Ac-dPro-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 181 );Ac-Nle-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 182);Ac-Nle-Nle-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 183);Ac-dVal-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 184);Ac-Arg-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 187);Ac-Arg-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 191 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 194);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 195);Ac-dPhe-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 196);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dVal-dPro-NH2(SEQ ID NO: 197);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 198);Ac-Nle-c[Asp-Pro-dNal(2')-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 199);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Gly-Lys]-dVal-dPro-NH2(SEQ ID NO: 200);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 201 );Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 202);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 203);Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 204);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 205);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 206);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 207);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 208);Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 209);-51 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 210); Ac-Nle-c[Asp-Ala-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 212); Ac-Nle-c[Asp-Gly-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 213); Ac-Nle-c[Asp-Leu-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 214); Ac-dPhe-c[Asp-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 215); c[CO-cis-CH=CH-CO-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 216);Ac-Nle-c[Asp-His-dNal(2')-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 317); Ac-Nle-c[Asp-dLeu-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 322); Ac-Nle-c[Asp-dVal-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 323); Ac-Nle-c[dCys-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 217);Ac-Nle-c[Cys-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 218); Ac-Nle-c[Asp-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 219); Ac-Nle-c[dCys-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 321 ); Ac-dVal-dPro-c[Asp-Trp-Arg-dNal(2')-Pro-Lys]-Nle-NH2(SEQ ID NO: 319); and Ac-dVal-dPro-c[Lys-Trp-Arg-dNal(2')-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 320), wherein c represents cyclization via a lactam or disulfide bond.

[0065] In some embodiments of the sequence of Formula (I) or (IA), R4is not dNal(2’). In such embodiments, R4may be selected from dPhe, p(F)dPhe, p(CI)dPhe, and p(Br)dPhe. Accordingly, in some embodiments, the sequence of Formula (I) or (IA) is a sequence of Formula (IA(ii)) :X1-X2- R1- R2- R3- R4- R5- R6- R7-Y1-Y2-Y3-Y4( I A(i i)) , wherein:X1is absent or Nle;X2is absent or Nle;R1is absent or is selected from the group consisting of Nle, dNIe, His, dHis, dPhe, Arg, and dArg;R2is selected from the group consisting of Asp, Cys, dCys, Pen, and Glu;R3is absent or selected from the group consisting of His, Pro, Trp-Pro, Pro-His, dAla, Pro-Pro, Pro-His, Arg, dBip, and dTyr;R4is selected from the group consisting of dPhe, p(F)dPhe, p(CI)dPhe, and p(Br)dPhe;-52-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOR5is selected from the group consisting of Arg, Pro, and His;R6is selected from the group consisting of Trp, Nal(2’), and Nal( 1 ’);R7is selected from the group consisting of Lys, Cys, and Orn;Y1is selected from the group consisting of dVal, dTle, dLys, Asp, dThr, p2Val, p3Val, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, pPro, and Vai;Y3is absent, dVal, or dThr;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R2and R7when R2is Asp and R7is Lys, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2is Cys, dCys, or Pen and R7is Cys, provided that: when R4is p(F)dPhe, then R3is Pro, and either (i) R6is not Trp or (ii) Y1and Y2are each independently dVal or dTle, when R4is p(CI)dPhe, then R3is His, R1is dArg, and Y1is dVal, when R4is p(Br)dPhe, then R3is dTyr or His, wherein when R3is His then either (i) R1is His or dHis and Y1is dTle or (ii) R2is dCys and R7is Cys, when R4is dPhe and R3is Pro, then the N-terminus is acetylated, R1is dNIe, dPhe or Nle, R2is Cys or Asp, R5is Arg or Pro, R6is Trp, and the C-terminus is amidated, wherein when R1is Nle, then either (i) Y1is dVal, Y2is dPro and at least one of X1-X2is Nle, (ii) Y1is dVal or Lys and Y2is dArg or Vai, or (iii) Y1is dLys, Asp, dThr, p2Val, or p3Val, and Y2is not dVal, when R4is dPhe, and R3is not Pro, then X1-X2are absent, R1is Nle, or Arg, Y1is dVal, Y2is dPro and Y3-Y4are absent, and either (i) R3is absent and R7is Cys, (ii) R3is Trp-Pro and either R5is His, or R6is Nal(1 ’), (iii) R3is Pro-His, R1is Nle and R5is His, (iv) R3is dAla and R1is Arg, or (vi) R3is selected from dBip, Pro-Pro, and Arg.-53-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0066] In some embodiments, the non-naturally occurring melanocortin analog comprises a sequence of Formula (IA(ii)) :X1-X2- R1- R2- R3- R4- R5- R6- R7-Y1-Y2-Y3-Y4( I A(i i)) , wherein:X1is absent or Nle;X2is absent or Nle;R1is absent or is selected from the group consisting of Nle, dNIe, His, dHis, dPhe, Arg, and dArg;R2is selected from the group consisting of Asp, Cys, dCys, Pen, and Glu;R3is absent or selected from the group consisting of His, Pro, Trp-Pro, Pro-His, dAla, Pro-Pro, Pro-His, Arg, dBip, and dTyr;R4is selected from the group consisting of dPhe, p(F)dPhe, p(CI)dPhe, and p(Br)dPhe;R5is selected from the group consisting of Arg, Pro, and His;R6is selected from the group consisting of Trp, Nal(2’), and Nal( 1 ’);R7is selected from the group consisting of Lys, Cys, and Orn;Y1is selected from the group consisting of dVal, dTle, dLys, Asp, dThr, p2Val, p3Val, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, pPro, and Vai;Y3is absent, dVal, or dThr;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R2and R7when R2is Asp and R7is Lys, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7isOrn, and a disulfide bond between R2and R7, when R2is Cys, dCys, or Pen and R7isCys, provided that:-54-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO when R4is p(F)dPhe, then R3is Pro, and either (i) R6is not Trp or (ii) Y1and Y2are each independently dVal or dTle, when R4is p(CI)dPhe, then R3is His, R1is dArg, and Y1is dVal, when R4is p(Br)dPhe, then R3is dTyr or His, wherein when R3is His then either (i) R1is His or dHis and Y1is dTle or (ii) R2is dCys and R7is Cys, when R4is dPhe and R3is Pro, then the N-terminus is acetylated, R1is dNIe, dPhe or Nle, R2is Cys or Asp, R5is Arg or Pro, R6is Trp, and the C-terminus is amidated, wherein when R1is Nle, then either (i) Y1is dVal, Y2is dPro and at least one of X1-X2is Nle, (ii) Y1is dVal or Lys and Y2is dArg or Vai, or (iii) Y1is dLys, Asp, dThr, p2Val, or p3Val, and Y2is not dVal, when R4is dPhe, and R3is not Pro, then X1-X2are absent, R1is Nle, or Arg, Y1is dVal, Y2is dPro and Y3-Y4are absent, and either (i) R3is absent and R7is Cys, (ii) R3is Trp-Pro and either R5is His, or R6is Nal(1 ’), (iii) R3is Pro-His, R1is Nle and R5is His, (iv) R3is dAla and R1is Arg, or (vi) R3is selected from dBip, Pro-Pro, and Arg.

[0067] In some embodiments, the non-naturally occurring melanocortin analog comprises a sequence of Formula (IA(ii)), wherein:X1is absent or Nle;X2is absent or Nle;R1is absent or is selected from the group consisting of Nle, dNIe, His, dHis, dPhe, Arg, and dArg;R2is selected from the group consisting of Asp, Cys, dCys, Pen, and Glu;R3is absent or selected from the group consisting of His, Pro, Trp-Pro, Pro-His, dAla, Pro-Pro, Pro-His, Arg, dBip, and dTyr;R4is selected from the group consisting of dPhe, p(F)dPhe, p(CI)dPhe, and p(Br)dPhe;R5is selected from the group consisting of Arg, Pro, and His;R6is selected from the group consisting of Trp, Nal(2’), and Nal( 1 ’);R7is selected from the group consisting of Lys, Cys, and Orn;Y1is selected from the group consisting of dVal, dTle, dLys, Asp, dThr, p2Val, p3Val, and Lys;-55-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOY2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, pPro, and Vai;Y3is absent, dVal, or dThr;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R2and R7when R2is Asp and R7is Lys, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2is Cys, dCys, or Pen and R7is Cys, provided that the non-naturally occurring melanocortin analog does not comprise a sequence selected from the group consisting of:Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 51 );Ac-His-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 52);Ac-dHis-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 53);Ac-Nle-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 54);Ac-Nle-c[Asp-Pro-p(F)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 55);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 56);Ac-Nle-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 57);Ac-dArg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 58);Ac-Arg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 59);Ac-His-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 60);Ac-dHis-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 61 );Ac-Nle-c[Cys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 62);Ac-Nle-c[dCys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 63);Ac-dArg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 65);Ac-Arg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 66);Ac-His-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 67);Ac-dHis-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 68);-56-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 69);Ac-Nle-c[Asp-His-p(F)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 70);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 71 );Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 72);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 73);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 74);Ac-Nle-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 75);Ac-dArg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 76);Ac-Arg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 77);Ac-His-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 78);Ac-dHis-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 79);Ac-Nle-c[Cys-Pro-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 80);Ac-Nle-c[dCys-Pro-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 81 );Ac-dArg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 83);Ac-Arg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 84);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 87);Ac-Nle-c[Asp-Trp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 89);Ac-Nle-c[Asp-His-p(F)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 96);Ac-Nle-c[Asp-Pro-p(F)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 97);Ac-Nle-c[Asp-Pro-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 105);Ac-dPhe-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 106);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 107);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 108);Ac-Nle-c[Pen-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 93);Ac-Nle-c[Asp-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 94);Ac-Nle-c[Pen-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 93);Ac-Nle-c[Asp-dBip-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 331 );Ac-Nle-c[Asp-dTyr-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 332);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 109);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 110);Ac-Nle-c[Cys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 111 );-57-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[dCys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 112);Ac-Arg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 114);Ac-His-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 115);Ac-dHis-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 1 16);Ac-Nle-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 117);Ac-Nle-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 118);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 1 19);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 120);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 121 );Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 122);Ac-Nle-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 123);Ac-dArg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 124);Ac-Arg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 125);Ac-His-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 126);Ac-dHis-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 127);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-NH2(SEQ ID NO: 132);Ac-Nle-c[Asp-Pro-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 134);Ac-Nle-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 118);Ac-Arg-c[Asp-Pro-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 135);Ac-Arg-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 136);Ac-Nle-c[Asp-Trp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 137);Ac-Nle-c[Asp-His-p(CI)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 143);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 144);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 148);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 153);Ac-Nle-c[Asp-Pro-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 154);Ac-Nle-c[Pen-p(CI)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 140);Ac-Nle-c[Asp-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 141 );Ac-Nle-c[Asp-dBip-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 325);Ac-Nle-c[Asp-dTyr-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 326);Ac-Nle-c[Cys-His-p(Br)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 155);-58-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-dArg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 156);Ac-Arg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 157);Ac-His-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 158);Ac-dHis-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 159);Ac-Nle-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 160);Ac-Nle-c[Asp-His-p(Br)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 161 );Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 162);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 163);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 164);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 165);Ac-Nle-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 166);Ac-dArg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 167);Ac-Arg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 168);Ac-Nle-c[Asp-dBip-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 169);Ac-Nle-c[Asp-Pro-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 170);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 171 );Ac-Nle-c[Asp-Pro-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 221 );Ac-Nle-c[Asp-Pro-dPhe-Arg-Nal(1')-Lys]-dVal-dPro-NH2(SEQ ID NO: 224);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dThr-dPro-dThr-OH (SEQ ID NO: 225);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 226);His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 227); dPhe-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 228); dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 229);Ac-Nle-c[Asp-Pro-dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 230);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 231 );Ac-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 232);Ac-dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 233);Ac-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dLys-dPro-NH2 (SEQ ID NO: 235);Ac-Nle-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 236);Ac-dArg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 238);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 239);-59-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 240);Ac-dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 241 );Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dVal-dPro-NH2 (SEQ ID NO: 243);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dLys-dVal-dPro-NH2 (SEQ ID NO: 244);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 246);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dTle-dPro-NH2 (SEQ ID NO: 247);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 248);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dTle-NH2(SEQ ID NO: 249);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dPro-NH2(SEQ ID NO: 250);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 251 );Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-dVal-dPro-NH2(SEQ ID NO: 252);Ac-dArg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 253);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dPro-dVal-NH2 (SEQ ID NO: 257);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dPro-NH2 (SEQ ID NO: 258);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 4);Ac-Nle-c[dCys-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 259);Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 262);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 266);Ac-Nle-c[Asp-dTyr-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 269);Ac-dHis-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 274);Ac-His-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 275);Ac-Nle-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 276);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dLys-dVal-dPro-NH2 (SEQ ID NO: 278);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dLys-dPro-NH2 (SEQ ID NO: 280);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 281 );Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 282);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 283);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 284);Ac-Nle-c[Asp-Pro-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 288);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 289);Ac-Nle-c[Cys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 290);-60-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[dCys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2 (SEQ ID NO: 291 ); Ac-Arg-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 292); Ac-dArg-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 293); Ac-His-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 295); Ac-Arg-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 307); Ac-Nle-c[Asp-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 308);Ac-Arg-c[Asp-Pro-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 309); Ac-Arg-c[Asp-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 310); Ac-Nle-c[Asp-His-dPhe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 313); Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 314); Ac-Arg-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 315); Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 147);Ac-Nle-c[Asp-His-dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 316); Ac-Nle-c[dCys-Trp-Pro-dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 333); Ac-dArg-c[Asp-dAla-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 336); Ac-Nle-c[dPen-dPhe-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 286);Ac-Nle-c[Pen-dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 312); and Ac-Nle-c[Cys-dPhe-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 337), wherein c represents cyclization via a lactam or disulfide bond.

[0068] In some embodiments, the non-naturally occurring melanocortin analog is selective for the melanocortin 1 receptor over the other melanocortin receptors. For example, the melanocortin analog may only bind the melanocortin 1 receptor, may selectively bind the melanocortin 1 receptor, or may bind the melanocortin 1 receptor with substantially higher affinity that other melanocortin receptors. Accordingly, in some embodiments, the sequence of Formula (I) is a sequence of Formula (IB):X1- R1- R2- R3- R4- R5- R6- R7-Y1-Y2(I B) , wherein:X1is absent or dVal;R1is selected from Nle, dArg, and dPro;R2is selected from the group consisting of Asp, Lys, Cys, and dCys;-61 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOR3is absent or selected from the group consisting of His, Pro, dAla, Trp-Arg, dLeu, dVal, dPhe, Bip, dBip, dTyr, Trp-Pro, Cpe, Che, Phe-Pro, dHis-Pro, dPro, Hyp, His-Arg, Pro-Arg, Arg-Pro, Acpc, Glu-His, Trp-dLeu, Trp-dVal, dlle, dTrp, and dGIn;R4is selected from the group consisting of dNal(2’), Bip, dBip, dPhe, p(F)dPhe, p(CI)dPhe, p(l)dPhe, and p(Br)dPhe;R5is Arg or Pro;R6is absent or is selected from the group consisting of Trp, Trp-Pro, dNal(1 ’), Phe, dPhe, and Tic;R7is selected from the group consisting of Lys, Asp, Cys, dCys, and Pen;Y1is dVal or Nle;Y2is absent, dPro, or Nle; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R2and R7when R2is Asp and R7is Lys, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a disulfide bond between R2and R7, when R2is Cys or dCys and R7is Cys, dCys, or Pen, provided that: when R4is dNal(2’), then R3is not Pro, Hyp, dAla, or Trp-Pro, wherein when R3is absent, then R2is dCys and R7is Cys, and when R3is Trp-Arg, then Y1is Nle, and either (i) Y2is absent and R2is Asp or (ii) Y2is Nle and R2is Lys, when R4is p(F)dPhe, then R3is dPhe, dBip, dTyr, or dTrp, when R4is p(CI)dPhe, then R3is dPhe, dBip, or dTyr, when R4is p(Br)dPhe, then R3is dPhe, Bip, dTrp, dGIn, or His, wherein when R3is His then R7is dCys, when R4is p(l)dPhe, then R3is Arg-Pro, when R4is dBip, then R2is Asp and R3is not Pro, when R4is dPhe, then R3is not Pro, Trp-Arg, dPhe, dTyr, dGIn, dTrp, dLeu, Bip, or dBip, wherein when R3is dAla, then R1is dArg, when R3is His, then R5is Pro, when R3is-62-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOHyp, then R6is Trp-Pro, and when R3is Trp-Pro, then either (i) R6is not Trp or (ii) R7is dCys.

[0069] In some embodiments, the non-naturally occurring melanocortin analog comprises a sequence of Formula (IB):X1- R1- R2- R3- R4- R5- R6- R7-Y1-Y2(I B) , wherein:X1is absent or dVal;R1is selected from Nle, dArg, and dPro;R2is selected from the group consisting of Asp, Lys, Cys, and dCys;R3is absent or selected from the group consisting of His, Pro, dAla, Trp-Arg, dLeu, dVal, dPhe, Bip, dBip, dTyr, Trp-Pro, Cpe, Che, Phe-Pro, dHis-Pro, dPro, Hyp, His-Arg, Pro-Arg, Arg-Pro, Acpc, Glu-His, Trp-dLeu, Trp-dVal, dlle, dTrp, and dGIn;R4is selected from the group consisting of dNal(2’), Bip, dBip, dPhe, p(F)dPhe, p(CI)dPhe, p(l)dPhe, and p(Br)dPhe;R5is Arg or Pro;R6is absent or is selected from the group consisting of Trp, Trp-Pro, dNal(1 ’), Phe, dPhe, and Tic;R7is selected from the group consisting of Lys, Asp, Cys, dCys, and Pen;Y1is dVal or Nle;Y2is absent, dPro, or Nle; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R2and R7when R2is Asp and R7is Lys, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a disulfide bond between R2and R7, when R2is Cys or dCys and R7is Cys, dCys, or Pen, provided that: when R4is dNal(2’), then R3is not Pro, Hyp, dAla, or Trp-Pro, wherein when R3is absent, then R2is dCys and R7is Cys, and when R3is Trp-Arg, then Y1is Nle, and either (i) Y2is absent and R2is Asp or (ii) Y2is Nle and R2is Lys,-63-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO when R4is p(F)dPhe, then R3is dPhe, d Bip, dTyr, or dTrp, when R4is p(CI)dPhe, then R3is dPhe, dBip, or dTyr, when R4is p(Br)dPhe, then R3is dPhe, Bip, dTrp, dGIn, or His, wherein when R3is His then R7is dCys, when R4is p(l)dPhe, then R3is Arg-Pro, when R4is dBip, then R2is Asp and R3is not Pro, when R4is dPhe, then R3is not Pro, Trp-Arg, dPhe, dTyr, dGIn, dTrp, dLeu, Bip, or dBip, wherein when R3is dAla, then R1is dArg, when R3is His, then R5is Pro, when R3is Hyp, then R6is Trp-Pro, and when R3is Trp-Pro, then either (i) R6is not Trp or (ii) R7is dCys.

[0070] in some embodiments, the non-naturally occurring melanocortin analog comprises a sequence of Formula (IB), wherein:X1is absent or dVal;R1is selected from Nle, dArg, and dPro;R2is selected from the group consisting of Asp, Lys, Cys, and dCys;R3is absent or selected from the group consisting of His, Pro, dAla, Trp-Arg, dLeu, dVal, dPhe, Bip, dBip, dTyr, Trp-Pro, Cpe, Che, Phe-Pro, dHis-Pro, dPro, Hyp, His-Arg, Pro-Arg, Arg-Pro, Acpc, Glu-His, Trp-dLeu, Trp-dVal, dlle, dTrp, and dGIn;R4is selected from the group consisting of dNal(2’), Bip, dBip, dPhe, p(F)dPhe, p(CI)dPhe, p(l)dPhe, and p(Br)dPhe;R5is Arg or Pro;R6is absent or is selected from the group consisting of Trp, Trp-Pro, dNal(1 ’), Phe, dPhe, and Tic;R7is selected from the group consisting of Lys, Asp, Cys, dCys, and Pen;Y1is dVal or Nle;Y2is absent, dPro, or Nle; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R2and R7when R2is Asp and R7is Lys, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp,-64-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO a disulfide bond between R2and R7, when R2is Cys or dCys and R7is Cys, dCys, or Pen, provided that the non-naturally occurring melanocortin analog does not comprise a sequence selected from the group consisting of:Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-NH2(SEQ ID NO: 29);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Phe-Lys]-dVal-dPro-NH2(SEQ ID NO: 41 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-dPhe-Lys]-dVal-dPro-NH2(SEQ ID NO: 42);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-dNal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 43);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Nal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 48);Ac-Nle-c[Asp-Hyp-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 39);Ac-Nle-c[Asp-Hyp-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 40);Ac-dArg-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 179);Ac-dPro-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 181 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 194);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 195);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dVal-dPro-NH2(SEQ ID NO: 197);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 198);Ac-Nle-c[Asp-Pro-dNal(2')-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 199);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 201 );Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 202);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 203);Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 204);Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 209);Ac-Nle-c[Asp-His-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 338);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 339);Ac-Nle-c[Asp-dAla-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 340);Ac-Nle-c[Asp-Trp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 341 );Ac-Nle-c[Cys-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 342);Ac-Nle-c[dCys-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 343);Ac-Nle-c[Cys-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 344);Ac-Nle-c[dCys-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 217);-65-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Cys-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 218);Ac-Nle-c[Asp-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 219);Ac-Nle-c[Asp-Trp-Arg-dNal(2')-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 345);Ac-Nle-c[Lys-Trp-Arg-dNal(2')-Pro-Asp]-dVal-dPro-NH2(SEQ ID NO: 346);Ac-dVal-dPro-c[Lys-Trp-Arg-dNal(2')-Pro-Asp]-Nle-NH2(SEQ ID NO: 347);Ac-dVal-dPro-c[Asp-Trp-Arg-dNal(2')-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 348);Ac-dVal-dPro-c[Asp-Trp-Arg-dNal(2')-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 349);Ac-dVal-dPro-c[Lys-Trp-Arg-dNal(2')-Pro-Asp]-dVal-dPro-NH2(SEQ ID NO: 350);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 51 );Ac-Nle-c[Cys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 62);Ac-Nle-c[dCys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 63);Ac-Nle-c[dCys-His-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 64);Ac-dArg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 65);Ac-Nle-c[Cys-Pro-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 80);Ac-Nle-c[dCys-Pro-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 81 );Ac-Nle-c[dCys-Pro-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 82);Ac-dArg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 83);Ac-Nle-c[Asp-Bip-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 85);Ac-Nle-c[Asp-dGln-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 86);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 87);Ac-Nle-c[Asp-Trp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 89);Ac-Nle-c[Asp-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 94);Ac-Nle-c[Asp-His-p(F)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 96);Ac-Nle-c[Asp-Pro-p(F)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 97);Ac-dVal-dPro-c[Lys-Trp-Arg-p(F)dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 100);Ac-dVal-dPro-c[Asp-Trp-Arg-p(F)dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 101 );Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 107);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 108);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 109);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 110);Ac-Nle-c[Cys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 111 );-66-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[dCys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 112);Ac-Nle-c[dCys-His-p(CI)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 113);Ac-Nle-c[Asp-dGln-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 128);Ac-Nle-c[Asp-dTrp-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 129);Ac-Nle-c[Asp-Bip-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 130);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-NH2(SEQ ID NO: 132);Ac-Nle-c[Asp-Trp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 137);Ac-Nle-c[Asp-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 141 );Ac-Nle-c[Asp-His-p(CI)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 143);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 144);Ac-dVal-dPro-c[Lys-Trp-Arg-p(CI)dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 149);Ac-dVal-dPro-c[Asp-Trp-Arg-p(CI)dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 150);Ac-dArg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 351 );Ac-Nle-c[Cys-His-p(Br)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 155);Ac-dArg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 156);Ac-Nle-c[Asp-dBip-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 169);Ac-Nle-c[Asp-Pro-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 170);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 171 );Ac-Nle-c[dCys-His-p(Br)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 352);Ac-Nle-c[Asp-dTyr-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 353);Ac-Nle-c[Asp-His-Arg-p(l)dPhe-Arg-Tic-Lys]-dVal-dPro-NH2(SEQ ID NO: 172);Ac-Nle-c[Asp-Pro-Arg-p(l)dPhe-Arg-Tic-Lys]-dVal-dPro-NH2(SEQ ID NO: 173);Ac-Nle-c[Asp-Pro-p(l)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 174);Ac-Nle-c[Asp-His-p(l)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 175);Ac-Nle-c[Asp-Pro-dBip-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 176);Ac-Nle-c[Lys-His-Arg-dBip-Arg-Tic-Asp]-dVal-dPro-NH2(SEQ ID NO: 177);Ac-Nle-c[Lys-Pro-Arg-dBip-Arg-Tic-Asp]-dVal-dPro-NH2(SEQ ID NO: 178);Ac-Nle-c[dCys-Pro-dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 223);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 226);Ac-dArg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 253);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 4);-67-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[dCys-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 259); Ac-Nle-c[Asp-Pro-dPhe-Arg-Phe-Lys]-dVal-dPro-NH2(SEQ ID NO: 261 ); Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 262);Ac-dVal-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 265);Ac-Nle-c[Asp-Pro-dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 354); Ac-Nle-c[Cys-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 355); Ac-Nle-c[Asp-dPhe-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 268); Ac-Nle-c[Asp-Hyp-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 287);Ac-Nle-c[Asp-dTyr-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 269); Ac-Nle-c[Asp-dGln-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 270); Ac-Nle-c[Asp-dTrp-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 271 ); Ac-Nle-c[Asp-Bip-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 272);Ac-Nle-c[Asp-dBip-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 356); Ac-Nle-c[Asp-dLeu-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 297); Ac-dVal-dPro-c[Lys-Trp-Arg-dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 303); Ac-dVal-dPro-c[Asp-Trp-Arg-dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 304);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 284);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 285); Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 289); Ac-Nle-c[Cys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 290); Ac-Nle-c[dCys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 291 );Ac-dArg-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 293); Ac-Arg-c[Asp-dAla-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 357);Ac-Nle-c[Asp-dAla-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 311 ); and Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 314), wherein c represents cyclization via a lactam or disulfide bond.

[0071] In some embodiments of the sequence of Formula (I) or (IB), R4is selected from dNal(2’), dPhe, p(F)dPhe, p(CI)dPhe, and p(Br)dPhe. In further embodiments, R3is not Pro. Accordingly, in some embodiments, the sequence of Formula (I) or (IB) is a sequence of Formula (IB(i)):R1- R2- R3- R4- R5- R6-R7-Y1-Y2(I B (i) ) ,-68-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO wherein:R1is Nle, or dArg;R2is selected from the group consisting of Asp, Lys, Cys, and dCys;R3is absent or selected from the group consisting of His, dAla, dLeu, dVal, dPhe, Bip, dBip, dTyr, Trp-Pro, Cpe, Che, Phe-Pro, dHis-Pro, dPro, Hyp, Acpc, Glu-His, Trp- dLeu, Trp-dVal, dlle, dTrp, and dGIn;R4is selected from the group consisting of dNal(2’), dPhe, p(F)dPhe, p(CI)dPhe, and p(Br)dPhe;R5is Arg or Pro;R6is absent or is selected from the group consisting of Trp, Trp-Pro, dNal(1 ’), Phe, and dPhe;R7is selected from the group consisting of Lys, Asp, Cys, dCys, and Pen;Y1is dVal;Y2is dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R2and R7when R2is Asp and R7is Lys, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a disulfide bond between R2and R7, when R2is Cys or dCys and R7is Cys, dCys, or Pen, provided that: when R4is dNal(2’), then R3is not Hyp, dAla, or Trp-Pro, and when R3is absent, then R2is dCys and R7is Cys, when R4is p(F)dPhe, then R3is dPhe, dBip, dTyr, or dTrp, when R4is p(CI)dPhe, then R3is dPhe, dBip, or dTyr, when R4is p(Br)dPhe, then R3is dPhe, Bip, dTrp, dGIn, or His, wherein when R3is His then R7is dCys, when R4is dPhe, then R3is not dPhe, dTyr, dGIn, dTrp, dLeu, Bip, or dBip, wherein when R3is dAla, then R1is dArg, when R3is His, then R5is Pro, when R3is Hyp, then R6is Trp-Pro, and when R3is Trp-Pro, then either (i) R6is not Trp or (ii) R7is dCys.-69-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0072] In some embodiments, the non-naturally occurring melanocortin analog comprises a sequence of Formula (IB(i)):R1- R2- R3- R4- R5- R6-R7-Y1-Y2(I B (i) ) , wherein:R1is Nle, or dArg;R2is selected from the group consisting of Asp, Lys, Cys, and dCys;R3is absent or selected from the group consisting of His, dAla, dLeu, dVal, dPhe, Bip, dBip, dTyr, Trp-Pro, Cpe, Che, Phe-Pro, dHis-Pro, dPro, Hyp, Acpc, Glu-His, Trp- dLeu, Trp-dVal, dlle, dTrp, and dGIn;R4is selected from the group consisting of dNal(2’), dPhe, p(F)dPhe, p(CI)dPhe, and p(Br)dPhe;R5is Arg or Pro;R6is absent or is selected from the group consisting of Trp, Trp-Pro, dNal(1 ’), Phe, and dPhe;R7is selected from the group consisting of Lys, Asp, Cys, dCys, and Pen;Y1is dVal;Y2is dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R2and R7when R2is Asp and R7is Lys, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a disulfide bond between R2and R7, when R2is Cys or dCys and R7is Cys, dCys, or Pen, provided that: when R4is dNal(2’), then R3is not Hyp, dAla, or Trp-Pro, and when R3is absent, then R2is dCys and R7is Cys, when R4is p(F)dPhe, then R3is dPhe, dBip, dTyr, or dTrp, when R4is p(CI)dPhe, then R3is dPhe, dBip, or dTyr, when R4is p(Br)dPhe, then R3is dPhe, Bip, dTrp, dGIn, or His, wherein when R3is His then R7is dCys,-70-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO when R4is dPhe, then R3is not dPhe, dTyr, dGIn, dTrp, dLeu, Bip, or dBip, wherein when R3is dAla, then R1is dArg, when R3is His, then R5is Pro, when R3is Hyp, then R6is Trp-Pro, and when R3is Trp-Pro, then either (i) R6is not Trp or (ii) R7is dCys.

[0073] In some embodiments, the non-naturally occurring melanocortin analog comprises a sequence of Formula (IB(i)), wherein:R1is Nle, or dArg;R2is selected from the group consisting of Asp, Lys, Cys, and dCys;R3is absent or selected from the group consisting of His, dAla, dLeu, dVal, dPhe, Bip, dBip, dTyr, Trp-Pro, Cpe, Che, Phe-Pro, dHis-Pro, dPro, Hyp, Acpc, Glu-His, Trp- dLeu, Trp-dVal, dlle, dTrp, and dGIn;R4is selected from the group consisting of dNal(2’), dPhe, p(F)dPhe, p(CI)dPhe, and p(Br)dPhe;R5is Arg or Pro;R6is absent or is selected from the group consisting of Trp, Trp-Pro, dNal(1 ’), Phe, and dPhe;R7is selected from the group consisting of Lys, Asp, Cys, dCys, and Pen;Y1is dVal;Y2is dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R2and R7when R2is Asp and R7is Lys, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a disulfide bond between R2and R7, when R2is Cys or dCys and R7is Cys, dCys, or Pen, provided that the non-naturally occurring melanocortin analog does not comprise a sequence selected from the group consisting of: Ac-Nle-c[Asp-Hyp-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 39);Ac-Nle-c[Asp-Hyp-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 40); Ac-Nle-c[Asp-His-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 338);-71 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-dAla-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 340);Ac-Nle-c[Asp-Trp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 341 );Ac-Nle-c[Cys-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 342);Ac-Nle-c[dCys-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 343);Ac-Nle-c[Cys-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 344);Ac-Nle-c[dCys-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 217);Ac-Nle-c[Cys-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 218);Ac-Nle-c[Asp-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 219);Ac-Nle-c[Cys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 62);Ac-Nle-c[dCys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 63);Ac-Nle-c[dCys-His-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 64);Ac-dArg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 65);Ac-Nle-c[Asp-Bip-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 85);Ac-Nle-c[Asp-dGln-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 86);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 87);Ac-Nle-c[Asp-Trp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 89);Ac-Nle-c[Asp-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 94);Ac-Nle-c[Asp-His-p(F)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 96);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 107);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 110);Ac-Nle-c[Cys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 111 );Ac-Nle-c[dCys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 112);Ac-Nle-c[dCys-His-p(CI)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 113);Ac-Nle-c[Asp-dGln-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 128);Ac-Nle-c[Asp-dTrp-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 129);Ac-Nle-c[Asp-Bip-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 130);Ac-Nle-c[Asp-Trp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 137);Ac-Nle-c[Asp-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 141 );Ac-Nle-c[Asp-His-p(CI)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 143);Ac-dArg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 351 );Ac-Nle-c[Cys-His-p(Br)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 155);-72-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-dArg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 156); Ac-Nle-c[Asp-dBip-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 169); Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 171 ); Ac-Nle-c[dCys-His-p(Br)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 352); Ac-Nle-c[Asp-dTyr-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 353); Ac-Nle-c[Asp-dPhe-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 268);Ac-Nle-c[Asp-Hyp-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 287); Ac-Nle-c[Asp-dTyr-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 269); Ac-Nle-c[Asp-dGln-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 270); Ac-Nle-c[Asp-dTrp-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 271 ); Ac-Nle-c[Asp-Bip-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 272); Ac-Nle-c[Asp-dBip-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 356);Ac-Nle-c[Asp-dLeu-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 297); Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 284); Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Pro-Lys]-dVal-dPro-NH2 (SEQ ID NO: 285); Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 289); Ac-Nle-c[Cys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2 (SEQ ID NO: 290); Ac-Nle-c[dCys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2 (SEQ ID NO: 291 );Ac-dArg-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 293); Ac-Arg-c[Asp-dAla-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 357);Ac-Nle-c[Asp-dAla-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 311 ); and Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 314), wherein c represents cyclization via a lactam or disulfide bond.

[0074] In some embodiments, the non-naturally occurring melanocortin analog has one or more beta hairpin (p-hairpin) and / or beta turn (p-turn) structures. In some embodiments, the presence of Pro, dPro, or Hyp, provides the p-hairpin and / or p-turn structures of the non- naturally occurring melanocortin analog. In some embodiments, the disulfide bond of the sequence of any one of Formulae (l)-(IB(i)), if present, provides the p-hairpin and / or p-turn structures of the non-naturally occurring melanocortin analog.-73-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0075] As will be appreciated by the skilled artisan, non-naturally occurring melanocortin analogs comprising a sequence of any one of Formulae (l)-(IB(i)), have an N- terminus and a C-terminus. The melanocortin analogs of the present technology are written beginning with the N-terminus at the left-most amino acid residue and ending with the C- terminus at the right most residue. Accordingly, the N-terminus of a non-naturally melanocortin analog comprising a sequence of any one of Formulae (l)-(IB(i)) may be at any of X1, X2, X3, R1, and R2. Analogously, the C-terminus of a non-naturally occurring melanocortin analog comprising a sequence of any one of Formulae (l)-(IB(i)) may be at any of Y1, Y2, Y3, and Y4.

[0076] In some embodiments, the N-terminus of the non-naturally occurring melanocortin analog is modified by an acyl group. In some embodiments, the acyl group is acetyl group

[0077] In some embodiments, the N-terminus of the non-naturally occurring melanocortin analog is not modified.

[0078] As discussed above, Y1Y2Y3Y4represents a C-terminus of the non-naturally occurring melanocortin analog. In some embodiments, Y1is present and Y2-Y4are absent. In some embodiments, Y1and Y2are present and Y3and Y4are absent. In some embodiments, Y1-Y3are present and Y4is absent. In some embodiments, Y1-Y4are present.

[0079] In some embodiments, the C-terminus of the non-naturally occurring melanocortin analog is modified by an amide groupthe sequence of any one of Formulae (l)-(IB(i)), a non-naturally occurring melanocortin analog with a C- terminus modified by an amide may be represented by a terminal -NH2.

[0080] In some embodiments, the C-terminus of the non-naturally occurring melanocortin analog is not modified. In the sequence of any one of Formulae (l)-(IB(i)), a-74-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO non-naturally occurring melanocortin analog with an unmodified C-terminus may be represented by -OH.

[0081] Non-naturally occurring melanocortin analogs comprising a sequence of any one of Formulae (l)-(IB(i)) are cyclized. For example, the non-naturally occurring melanocortin analog may be cyclized through a moiety selected from the group consisting of: a lactam bond between R1or R2and R7when R1or R2is Asp or CO-cis-CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen.

[0082] In some embodiments, the non-naturally occurring melanocortin analog comprises a sequence cyclized through a disulfide bond. In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is cyclized through a disulfide bond between R2and R7. In further embodiments, R4is dNal(2’). In still further embodiments, R3is absent. In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Cys-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 342);Ac-Nle-c[dCys-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 343);Ac-Nle-c[Cys-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 344);Ac-Nle-c[Pen-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 358);Ac-Nle-c[Pen-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 359);Ac-Nle-c[Pen-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 360);Ac-Nle-c[dPen-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 361 );Ac-Nle-c[dPen-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 362);Ac-Nle-c[Pen-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 363); andAc-Nle-c[dCys-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 321 ), wherein c represents cyclization through R2and R7via a disulfide bond.-75-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0083] In some embodiments, the non-naturally occurring melanocortin analog comprises a sequence cyclized through a disulfide bond and R3is present. In some embodiments, R3is Ala, Leu, dLeu, dVal, Gly, or Gly-Gly. In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[dPen-Ala-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 364);Ac-Nle-c[dPen-Leu-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 365);Ac-Nle-c[dPen-dLeu-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 366);Ac-Nle-c[dPen-dVal-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 367);Ac-Nle-c[dPen-Gly-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 368); andAc-Nle-c[dPen-Gly-Gly-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 369), wherein c represents cyclization through R2and R7via a disulfide bond.

[0084] Alternatively, in some embodiments, R3is Pro. In further embodiments, R1is Nle, or dPhe, R5is Arg, R6is Trp or Trp-Gly. In still further embodiments, Y1is dVal, dLys, or dArg, and Y2is dPro or dVal, and Y3is absent or dPro. In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 339);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 370);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 371 );Ac-dPhe-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 372);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dArg-dVal-dPro-NH2(SEQ ID NO: 373);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dArg-dPro-NH2(SEQ ID NO: 374);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dLys-dPro-NH2(SEQ ID NO: 375);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-Gly-dPen]-dVal-dPro-NH2(SEQ ID NO: 376); andAc-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dLys-dVal-dPro-NH2(SEQ ID NO: 377), wherein c represents cyclization through R2and R7via a disulfide bond.-76-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0085] In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is cyclized through a disulfide bond and R4is an amino acid other than dNal(2’). In some embodiments, R4is dPhe. In further embodiments, at least one of R3, R5, and R6is absent. In some embodiments, R3is absent. In other embodiments, R5and R6are absent. In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-c[Cys-Arg-dPhe-Cys]-Trp-dVal-dPro-NH2 (SEQ ID NO: 378);Ac-Nle-c[Pen-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2 (SEQ ID NO: 379); andAc-Nle-c[Cys-dPhe-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 337), wherein c represents cyclization through R2and R7via a disulfide bond.

[0086] In some embodiments, R4is dPhe or p(Br)dPhe. In further embodiments, R1is Nle, R3is His, Pro, or Trp-Pro, Y1is dVal, and Y2is dPro. In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Cys-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 355);Ac-Nle-c[dCys-His-p(Br)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 352);Ac-Nle-c[dCys-His-p(Br)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 327); andAc-Nle-c[dCys-Trp-Pro-dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 333), wherein c represents cyclization through R2and R7via a disulfide bond.

[0087] In some embodiments, the non-naturally occurring melanocortin analog comprises a sequence cyclized through a lactam bond. In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is cyclized through a lactam bond between R1or R2and R7. In some embodiments, R4is dBip or p(l)dPhe. In still further embodiments, one of R3is His-Arg, Pro-Arg, or Arg-Pro and R6is Tic. In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Asp-His-Arg-dBip-Arg-Tic-Lys]-dVal-dPro-NH2 (SEQ ID NO: 380);Ac-Nle-c[Asp-Pro-Arg-dBip-Arg-Tic-Lys]-dVal-dPro-NH2 (SEQ ID NO: 381 );Ac-Nle-c[Asp-Arg-Pro-p(l)dPhe-Arg-Tic-Lys]-dVal-dPro-NH2 (SEQ ID NO: 382); and-77-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Arg-Pro-dBip-Arg-Tic-Lys]-dVal-dPro-NH2 (SEQ ID NO: 383), wherein c represents cyclization through R2and R7via a lactam bond.

[0088] In some embodiments, R4is Bip. In further embodiments, R1is Nle, R3is Pro, Y1is dVal, and Y2is dPro. In some embodiments, the sequence of any one of Formulae (I)- (IB(i)) is Ac-Nle-c[Asp-Pro-Bip-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 384), wherein c represents cyclization through R2and R7via a lactam bond.

[0089] In some embodiments, R4is dPhe. In further embodiments, R3is dipeptide. In still further embodiments, R3is Phe-Pro, dHis-Pro, Pro-Pro, Trp-Pro, Trp-dLeu, or Trp-dVal. In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Asp-Phe-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 385);Ac-Nle-c[Asp-dHis-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 386);Ac-Nle-c[Asp-Pro-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 387);Ac-Nle-c[Asp-Trp-dLeu-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 388);Ac-Nle-c[Asp-Trp-dVal-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 389);Ac-Nle-c[Asp-Trp-Pro-dPhe-His-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 390);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Nal(1')-Lys]-dVal-dPro-NH2(SEQ ID NO: 391 );Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-dNal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 392);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Phe-Lys]-dVal-dPro-NH2 (SEQ ID NO: 393);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-dPhe-Lys]-dVal-dPro-NH2 (SEQ ID NO: 394), wherein c represents cyclization through R2and R7via a lactam bond.

[0090] In some embodiments, when R3is a dipeptide, R3is Pro-His. In further embodiments, R1is Nle, R5is His, Y1is dVal, and Y2is dPro. In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is:Ac-Nle-c[Asp-Pro-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 395); orAc-Nle-c[Glu-Pro-His-dPhe-His-Trp-Orn]-dVal-dPro-NH2(SEQ ID NO: 396),-78-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO wherein c represents cyclization through R2and R7via a lactam bond.

[0091] In some embodiments, R4is dPhe and R3is Pro. In further embodiments, R5is Arg and R6is Trp. In some embodiments, R1is Nle and Y1is an amino acid other than dVal and / or Y2is an amino acid other than dPro. Alternatively, in some embodiments, R1is an amino acid other than Nle or at least one of X1-X2are present, Y1is dVal and Y2is dPro. In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-dNle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 397);Ac-dPhe-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 398);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-Arg-NH2 (SEQ ID NO: 399);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dLys-dPro-NH2 (SEQ ID NO: 400);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-Val-Pro-NH2 (SEQ ID NO: 401 );Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Asp-NH2 (SEQ ID NO: 402);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dThr-dPro-dThr-NH2 (SEQ ID NO: 403);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-p2Val-pPro-NH2 (SEQ ID NO: 404);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-p3Val-pPro-NH2 (SEQ ID NO: 405);Ac-Nle-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 406); andAc-Nle-Nle-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 407), wherein c represents cyclization through R2and R7via a lactam bond.

[0092] In some embodiments, R4is dPhe and R3is an amino acid other than Pro. In further embodiments, R3is selected from dAla, dlle, dVal, Hyp, Cpe, Che, and dBip. In still further embodiments, R1is Nle, Arg, or dArg, Y1is dVal and Y2is dPro. In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Asp-dlle-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 408);Ac-Nle-c[Asp-Hyp-dPhe-Arg-Trp-Pro-Lys]-dVal-dPro-NH2 (SEQ ID NO: 409);-79-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-dVal-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 328);Ac-Nle-c[Asp-dBip-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 356);Ac-Arg-c[Asp-dAla-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 357);Ac-Nle-c[Asp-Cpe-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 334);Ac-Nle-c[Asp-Che-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 335); andAc-dArg-c[Asp-dAla-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 336), wherein c represents cyclization through R2and R7via a lactam bond.

[0093] In some embodiments, R4is dPhe and R5is an amino acid other than Arg or R6is an amino acid other than Trp. In further embodiments, R5is Pro or R6is dNal(1 ’). In still further embodiments, R1is Nle, R3is Pro or His, and R6is Trp. In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is:Ac-Nle-c[Asp-Pro-dPhe-Arg-dNal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 260);Ac-Nle-c[Asp-Pro-dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 354); andAc-Nle-c[Asp-His-dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 316), wherein c represents cyclization through R2and R7via a lactam bond.

[0094] In some embodiments, R4is selected from p(Br)dPhe, p(CI)dPhe, and p(F)dPhe. In some embodiments, R3is His or Pro. In further embodiments, R5is Arg and R6is Trp. In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 410);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 411 );Ac-dArg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 351 );Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 412);Ac-His-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 413); andAc-dHis-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 414),-80-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO wherein c represents cyclization through R2and R7via a lactam bond.

[0095] Alternatively, in some embodiments, R3is an amino acid other than His or Pro. In further embodiments, R3is selected from dGIn, Bip, dBip, dPhe, dTrp, and dTyr. In further embodiments, R1is Nle, R5is Arg, and R6is Trp. In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Asp-dTyr-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 353);Ac-Nle-c[Asp-dPhe-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 324);Ac-Nle-c[Asp-dBip-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 325);Ac-Nle-c[Asp-dTyr-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 326);Ac-Nle-c[Asp-dPhe-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 329);Ac-Nle-c[Asp-dPhe-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 330);Ac-Nle-c[Asp-dBip-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 331 );Ac-Nle-c[Asp-dTyr-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 332);Ac-Nle-c[Asp-dTrp-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 415);Ac-Nle-c[Asp-Bip-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 416);Ac-Nle-c[Asp-dGln-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 417); andAc-Nle-c[Asp-dTrp-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 418), wherein c represents cyclization through R2and R7via a lactam bond.

[0096] In some embodiments, R4is dNal(2’). In further embodiments, R3is Pro. In some embodiments, R5is Arg, R6is Trp, Y1is dVal, and Y2is dPro. In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-Nle-Nle-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 419);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-dOrn]-dVal-dPro-NH2(SEQ ID NO: 420); and c[CO-cis-CH=CH-CO-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 421 ), wherein c represents cyclization through R2and R7via a lactam bond.-81 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0097] Alternatively, in some embodiments, R3is Pro and R5is an amino acid other than Arg. In further embodiments, R5is selected from dLys, dArg, dOrn, Glu, dAsp, and dGlu. In still further embodiments, R1is Nle, Y1is dVal, and Y2is dPro. In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Asp-Pro-dNal(2')-dLys-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 422);Ac-Nle-c[Asp-Pro-dNal(2')-dArg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 423);Ac-Nle-c[Asp-Pro-dNal(2')-dOrn-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 424);Ac-Nle-c[Asp-Pro-dNal(2')-Glu-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 425);Ac-Nle-c[Asp-Pro-dNal(2')-dAsp-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 426); andAc-Nle-c[Asp-Pro-dNal(2')-dGlu-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 427), wherein c represents cyclization through R2and R7via a lactam bond.

[0098] In some embodiments, R4is dNal(2’) and an amino acid other than Pro. In further embodiments, R3is selected from His, dAla, dMet, Gly-Gly, p-Ala, Mamb, Che, Cpe, dLeu, dVal, dPro, dlle, dTrp, and Acpc. In still further embodiments, R5is Arg, R6is Trp or Trp-Pro, Y1is dVal, and Y2is dPro. In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Asp-His-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 338);Ac-Nle-c[Asp-dAla-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 340);Ac-Nle-c[Asp-dMet-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 428);Ac-Nle-c[Asp-Gly-Gly-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 429);Ac-Nle-c[Asp-p-Ala-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 430);Ac-Nle-c[Asp-Mamb-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 431 );Ac-Nle-c[Asp-Cpe-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 432);Ac-Nle-c[Asp-Che-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 433);Ac-Arg-c[Asp-dAla-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 434);-82-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-His-dNal(2')-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 317);Ac-dArg-c[Asp-dAla-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 318);Ac-Nle-c[Asp-dLeu-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 322);Ac-Nle-c[Asp-dVal-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 323);Ac-Nle-c[Asp-dPro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 435);Ac-Nle-c[Asp-dlle-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 436);Ac-Nle-c[Asp-dTrp-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 437); andAc-Nle-c[Asp-Acpc-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 438), wherein c represents cyclization through R2and R7via a lactam bond.

[0099] In some embodiments, R4is dNal(2’) and R3is a dipeptide. In further embodiments, R3is Pro-Glu, Glu-His, or Trp-Pro. In still further embodiments, R1is Nle, R5is Arg, and R6is Trp orTrp-Gly. In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Asp-Glu-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 439);Ac-Nle-c[Asp-Pro-Glu-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 440);Ac-Nle-c[Asp-Pro-Glu-dNal(2')-Arg-Trp-Gly-Lys]-dVal-dPro-NH2(SEQ ID NO: 441 );Ac-Nle-c[Asp-Trp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 341 ), wherein c represents cyclization through R2and R7via a lactam bond.

[0100] Alternatively, in some embodiments, R4is dNal(2’) and R3is Trp-Arg. In further embodiments, X1is dVal, Nle, or absent, R1is Nle, Pro, or dPro, R5is Pro or absent, and R6is absent. In still further embodiments, Y1is dVal or Nle and Y2is dPro, Nle, or absent. In some embodiments, the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Asp-Trp-Arg-dNal(2')-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 345);Ac-Nle-c[Asp-Pro-Trp-Arg-dNal(2')-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 442);Ac-Nle-c[Asp-Pro-Trp-Arg-dNal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 443);-83-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Lys-Trp-Arg-dNal(2')-Pro-Asp]-dVal-dPro-NH2(SEQ ID NO: 346);Ac-dVal-dPro-c[Lys-Trp-Arg-dNal(2')-Pro-Asp]-Nle-NH2(SEQ ID NO: 347);Ac-dVal-dPro-c[Asp-Trp-Arg-dNal(2')-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 348);Ac-dVal-dPro-c[Asp-Trp-Arg-dNal(2')-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 349);Ac-dVal-dPro-c[Lys-Trp-Arg-dNal(2')-Pro-Asp]-dVal-dPro-NH2(SEQ ID NO: 350);Ac-dVal-dPro-c[Asp-Trp-Arg-dNal(2')-Pro-Lys]-Nle-NH2(SEQ ID NO: 319); andAc-dVal-dPro-c[Lys-Trp-Arg-dNal(2')-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 320), wherein c represents cyclization through R1or R2and R7via a lactam bond.

[0101] In some embodiments, the non-naturally occurring melanocortin analog comprises a sequence of any one of SEQ ID NOs: 260 and 316-443.

[0102] In some embodiments, the non-naturally occurring melanocortin analog comprises a sequence of any one of Formulae (l)-(IA(ii)). Melanocortin analogs of any one of Formulae (l)-(IA(ii) may selectively bind the MC3R and / or MC4R over other melanocortin receptors. In some embodiments, the non-naturally occurring melanocortin analog comprises any one of SEQ ID NOs: 338-379, 387, 390, 391 , 395-407, 410-414, 419-434, 440-443.

[0103] In some embodiments, the non-naturally occurring melanocortin analog comprises a sequence of any one of Formulae (I), (IB), and (IB(i)). Melanocortin analogs of any one of Formulae (I), (IB), and (IB(i)) may selectively bind the MC1 R over other melanocortin receptors. In some embodiments, the non-naturally occurring melanocortin analog comprises any one of SEQ ID NOs: 260, 316-337, 380-386, 388, 389, 392-394, 408, 409, 415-418, and 435-439.

[0104] In some embodiments, the non-naturally occurring melanocortin receptor analog is in the form of a salt. In further embodiments, the non-naturally occurring melanocortin receptor analog is in the form of an acetate salt. In still further embodiments, the non-naturally occurring melanocortin receptor analog is in the form of an acetate salt and comprises a sequence of any one of Formulae (l)-(IB(i)). In yet further embodiments,-84-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO the non-naturally occurring melanocortin receptor analog is in the form of an acetate salt and comprises a sequence of any one of the sequences provided above.

[0105] The non-naturally occurring melanocortin receptor analog may be present in the pharmaceutical composition in an amount sufficient to elicit the desired therapeutic activity. In some embodiments, the non-naturally occurring melanocortin receptor analog is present in the pharmaceutical composition in an amount sufficient to treat, prevent, or reduce symptoms associated with the disease or condition. In further embodiments, the non- naturally occurring melanocortin receptor analog is present in the pharmaceutical composition in an amount sufficient to induce a desirable outcome in the subject having the disease or condition.

[0106] The pharmaceutical composition may include a non-naturally occurring melanocortin receptor analog at a concentration of about 0.01 mg / mL to about 200 mg / mL. For example, in some embodiments, the non-naturally occurring melanocortin receptor analog is present in the pharmaceutical composition at a concentration of about 0.01 mg / mL to about 175 mg / mL, about 0.02 mg / mL to about 150 mg / mL, about 0.04 mg / mL to about 100 mg / mL, about 0.05 mg / mL to about 50 mg / mL, about 0.06 mg / mL to about 20 mg / mL, about 0.08 mg / mL to about 15 mg / mL, or about 0.1 mg / mL to about 10 mg / mL. In some embodiments, the non-naturally occurring melanocortin receptor analog is present in the pharmaceutical composition at a concentration of about 0.01 mg / mL to about 9 mg / mL, about 0.01 mg / mL to about 8 mg / mL, about 0.01 mg / mL to about 7 mg / mL, about 0.01 mg / mL to about 6 mg / mL, about 0.01 mg / mL to about 5 mg / mL, about 0.01 mg / mL to about 4 mg / mL, about 0.01 mg / mL to about 3 mg / mL, about 0.01 mg / mL to about 2 mg / mL, about 0.05 mg / mL to about 2 mg / mL, about 0.05 mg / mL to about 5 mg / mL, about 0.1 mg / mL to about 50 mg / mL, about 0.1 mg / mL to about 25 mg / mL, about 0.1 mg / mL to about 10 mg / mL, about 0.1 mg / mL to about 5 mg / mL, about 0.1 mg / mL to about 2.5 mg / mL, about 0.1 mg / mL to about 1.5 mg / mL, about 0.5 mg / mL to about 1.5 mg / mL, or about 1 mg / mL. In some embodiments, the non-naturally occurring melanocortin receptor analog is present in the pharmaceutical composition at a concentration of about 10 mg / mL to about 200 mg / mL, about 20 mg / mL to about 200 mg / mL, about 60 mg / mL to about 200 mg / mL, about 80 mg / mL to about 200 mg / mL, about 100 mg / mL to about 200 mg / mL, about 100 mg / mL to about 180-85-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO mg / mL, about 120 mg / mL to about 180 mg / mL, about 120 mg / mL to about 160 mg / mL, about 10 mg / mL to about 100 mg / mL, about 20 mg / mL to about 80 mg / mL, or about 20 mg / mL to about 60 mg / mL.

[0107] The pharmaceutical compositions of the present technology may be formulated to deliver a certain dose of the non-naturally occurring melanocortin receptor analog to a subject in need thereof. The dose may be based on the body weight of the subject. For example, in some embodiments, the pharmaceutical composition is formulated to deliver the non-naturally occurring melanocortin receptor analog to the subject at a dose of about 0.01 mg / kg to about 1000 mg / kg, per body weight of the subject. In some embodiments, the pharmaceutical composition is formulated to deliver a dose of the non-naturally occurring melanocortin receptor analog of about 0.01 mg / kg to about 50 mg / kg, about 0.01 mg / kg to about 40 mg / kg, about 0.05 mg / kg to about 30 mg / kg, about 0.1 mg / kg to about 20 mg / kg, about 0.25 mg / kg to about 10 mg / kg, about 0.5 mg / kg to about 7.5 mg / kg, about 0.75 mg / kg to about 7 mg / kg, about 1 mg / kg to about 6.5 mg / kg, or about 1 mg / kg to about 6 mg / kg, per body weight of the subject. In some embodiments, the pharmaceutical composition is formulated to deliver a dose of the non-naturally occurring melanocortin receptor analog of about 0.01 mg / kg to about 10 mg / kg, about 0.01 mg / kg to about 7.5 mg / kg, about 0.01 mg / kg to about 5 mg / kg, about 0.01 mg / kg to about 2.5 mg / kg, about 0.01 mg / kg to about 1 .5 mg / kg, about 0.1 mg / kg to about 10 mg / kg, about 0.1 mg / kg to about 7.5 mg / kg, about 0.1 mg / kg to about 5 mg / kg, about 0.1 mg / kg to about 2.5 mg / kg, or about 0.1 mg / kg to about1.5 mg / kg, per body weight of the subject. In some embodiments, the pharmaceutical composition is formulated to deliver a dose of melanocortin receptor analog of about 0.1 mg / kg, about 0.25 mg / kg, about 0.5 mg / kg, about 0.75 mg / kg, 1 mg / kg, about 2.5 mg / kg, about 5 mg / kg, about 7.5 mg / kg, about 10 mg / kg, about 12.5 mg / kg, about 15 mg / kg, about17.5 mg / kg, about 20 mg / kg, about 22.5 mg / kg, or about 25 mg / kg, per body weight of the subject. In further embodiments, the pharmaceutical composition is formulated to deliver a dose of the non-naturally occurring melanocortin receptor analog of about 5 mg / kg, per body weight of the subject.

[0108] In some embodiments, the pharmaceutical composition includes the non- naturally occurring melanocortin receptor analog in an amount sufficient to deliver about-86-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO0.01 mg / kg to about 1000 mg / kg of the non-naturally occurring melanocortin receptor analog to the subject in need thereof. For example, in some embodiments, the pharmaceutical composition is formulated to deliver the non-naturally occurring melanocortin analog to the subject at a dose of about 1.0 mg to about 20 g. In some embodiments, the non-naturally occurring melanocortin analog is present in the pharmaceutical composition in an amount of about 5 mg to about 15 g, about 10 mg to about 10 g, about 100 mg to about 5 g, about 250 mg to about 2.5 g, about 250 mg to about 1 g, about 500 mg to about 5 g, about 500 mg to about 2.5 g, about 500 mg to about 1 g, or about 250 mg to about 750 mg.

[0109] In some embodiments, the pharmaceutical composition includes the non- naturally occurring melanocortin receptor analog in an amount sufficient to deliver about 0.01 mg / kg to about 10 mg / kg of the non-naturally occurring melanocortin receptor analog to the subject in need thereof. For example, in some embodiments, the pharmaceutical composition is formulated to deliver the non-naturally occurring melanocortin receptor analog to the subject at a dose of about 1 .0 mg to about 5000 mg. In some embodiments, the non-naturally occurring melanocortin receptor analog is present in the pharmaceutical composition in an amount of about 2.5 mg to about 2500 mg, about 5 mg to about 2000 mg, about 10 mg to about 1500 mg, or about 20 mg to about 1000 mg. In some embodiments, the non-naturally occurring melanocortin receptor analog is present in the pharmaceutical composition in an amount of about 0.5 mg to about 500 mg, about 1 mg to about 250 mg, about 2.5 mg to about 100 mg, about 5 mg to about 75 mg, about 10 mg to about 60 mg, or about 20 mg to about 50 mg. In some embodiments, the non-naturally occurring melanocortin receptor analog is present in the pharmaceutical composition in an amount of about 10 mg, about 20 mg, about 30 mg, about 40 mg, about 50 mg, about 60 mg, about 70 mg, about 80 mg, about 90 mg, about 100 mg, about 150 mg, about 200 mg, about 250 mg, about 300 mg, about 350 mg, about 400 mg, about 450 mg, about 500 mg, about 550 mg, about 600 mg, about 650 mg, about 700 mg, about 750 mg, about 800 mg, about 850 mg, about 900 mg, about 950 mg, about 1000 mg, about 1 100 mg, about 1200 mg, about 1300 mg, about 1400 mg, or about 1500 mg.

[0110] In some embodiments, the pharmaceutical composition comprises one or more pharmaceutically acceptable carriers and / or excipients. In some embodiments, the excipient-87-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO comprises or consists of an enzyme inhibitor, such as a protease inhibitor. The excipient may comprise one or more compounds which inhibit, bind, or otherwise target an enzyme selected from a phosphatase (e.g., an intestinal phosphatase), a protease (e.g., a metalloprotease, an endopeptidase, or an amino peptidase). The protease may be a trypsin, a trypsin-like protease, a chymotrypsin, an elastase, a pepsin, a mesotrypsin, a tryptase, and a chymase. In some embodiments, the excipient may comprise one or more compounds which inhibit, bind, or otherwise target an enzyme of the digestive tract, such as an intestinal enzyme.

[0111] Nonlimiting examples of suitable enzyme inhibitors used in accordance with the embodiments of the present technology include sodium fluoride, ethylenediaminetetraacetic acid (EDTA), aprotinin, pepstatin, bestatin, bacitracin, boric acid, a soybean trypsin inhibitor (SBTI), a Bowman-Birk inhibitor (BBI), and a Kunitz trypsin inhibitor (KTI).

[0112] In other embodiments, the pharmaceutical composition does not comprise any pharmaceutically acceptable carriers or excipients. Pharmaceutically acceptable carriers and / or excipients included in the pharmaceutical compositions of the present technology may be selected based on the carrier or excipient’s ability to confer desirable properties, such as reduced or lack of delivery site reactions, solubility, stability, pH, buffering, pharmacokinetics, bioavailability, and the like, to the pharmaceutical composition. For example, the one or more pharmaceutically acceptable carriers and / or excipients may be included in the pharmaceutical compositions described herein to provide improved pharmacokinetic properties and oral bioavailability.

[0113] The pharmaceutical compositions of the present technology may include at least one permeation enhancer. Inclusion of at least one permeation enhancer in the compositions and formulations of the present technology improves the pharmacokinetic properties and oral bioavailability of the non-naturally occurring melanocortin receptor analog such as, for example, uptake and stability of the non-naturally occurring melanocortin receptor analog in plasma and cerebrospinal fluid (CSF), as compared to a pharmaceutical composition or a formulation thereof of the non-naturally occurring melanocortin receptor analog without the permeation enhancer. In some embodiments, the permeation enhancer is included in the pharmaceutical composition in an amount sufficient-88-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO to achieve at least about a 2-fold increase, at least about a 3-fold increase, at least about a 4-fold increase, or at least about a 5-fold increase in a maximum concentration (Cmax) and / or area under the curve (AUG) values in a subject, relative to a pharmaceutical composition of the non-naturally occurring melanocortin receptor analog without the permeation enhancer. For example, the permeation enhancer may be present in the pharmaceutical composition in an amount sufficient to achieve Cmax and / or AUG levels at least about 5 times, at least about 10 times, at least about 15 times, or at least about 20 times greater that Cmax and AUG levels achieved with a pharmaceutical composition of the non-naturally occurring melanocortin receptor analog without the permeation enhancer.

[0114] The permeation enhancers may be GRAS when the pharmaceutical compositions or formulations thereof are used under one or more conditions of the present technology. In some embodiments, the permeation enhancer is a GRAS permeation enhancer. As will be appreciated, GRAS substances receive a Type of Conclusion score from the Select Committee on GRAS Substances (SCOGS), which further classifies substances based on how hazardous the substance is to the public at current consumption rates and use conditions and how hazardous the substance may be at increased consumption rates and different use conditions according to the available evidence, with a score of 1 representing the least potentially hazardous substances and a score of 5 representing the most potentially hazardous substances based on the current evidence. In some embodiments, the GRAS permeation enhancer has a SCOGS Type of Conclusion of Conclusion score of 1 or 2. In further embodiments, the GRAS permeation enhancer has a SCOGS Type of Conclusion score of 1 .

[0115] In some embodiments, the permeation enhancer is an inactive ingredient when used under one or more conditions of the present technology. For example, the permeation enhancer may be included in the U.S. Food and Drug Administration (FDA) Inactive Ingredient Database (IID) for route of administration (ROA) and quantity, or it may be qualified into the IID as a novel excipient. Likewise, the permeation enhancer may be considered inactive and / or otherwise safe by the European Medicines Agency (EMA), Health Canada, the International Pharmaceutical Excipient Council (IPEC), and / or other national health and drug agencies.-89-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0116] The permeation enhancers of the present technology and their respective amounts may be selected based on a desired modification in a pharmacokinetic (PK) or pharmacodynamic (PD) metric, relative to a control (e.g., a pharmaceutical composition or formulation lacking the permeation enhancers or having a different amount of the permeation enhancers). For example, the permeation enhancers and / or their respective amounts may be selected to increase an area under the curve (AUG) value of a pharmaceutical composition or formulation, relative to a control. The increase in the AUG value may comprise an increase in at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 150%, 200%, 250%, 300%, 350%, 400%, 450%, 500%, 600%, 700%, 800%, 900%, or 1000% relative to the control. In another example, the permeation enhancers and / or their respective amounts may be selected to increase a maximum concentration (Cmax) value of a pharmaceutical composition or formulation, relative to a control. The increase in the Cmax value may comprise an increase in at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 150%, 200%, 250%, 300%, 350%, 400%, 450%, 500%, 600%, 700%, 800%, 900%, or 1000% relative to the control.

[0117] In some embodiments, the pharmaceutical compositions of the present technology comprise one or more permeation enhancers. In some embodiments, the pharmaceutical compositions of the present technology comprise two or more permeation enhancers. In some embodiments, the permeation enhancer is selected from caprylic acid, salcaprozate sodium (SNAG), sodium caprate, sodium chenodeoxycholate, and propyl gallate. In some embodiments, the permeation enhancer is propyl gallate. In some embodiments, the permeation enhancer is a GRAS permeation enhancer. The GRAS permeation enhancer may comprise a substance included on the U.S. Food & Drug Administration’s GRAS Substances SCOGS Database.

[0118] The permeation enhancer may be present in the pharmaceutical composition in at a concentration of about 0.01 mg / mL to about 100 mg / mL. For example, in some embodiments, the permeation enhancer is present in the pharmaceutical composition at a concentration of about 0.01 mg / mL to about 75 mg / mL, about 0.025 mg / mL to about 50 mg / mL, about 0.05 mg / mL to about 40 mg / mL, about 0.075 mg / mL to about 30 mg / mL, or about 0.1 mg / mL to about 25 mg / mL. In some embodiments, the permeation enhancer is-90-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO present in the pharmaceutical composition at a concentration of about 0.01 mg / mL to about 10 mg / mL, about 0.1 mg / mL to about 7.5 mg / mL, about 0.1 mg / mL to about 5 mg / mL, about 0.1 mg / mL to about 2.5 mg / mL, about 0.1 mg / mL to about 2 mg / mL, about 0.1 mg / mL to about 1.5 mg / mL, or about 0.1 mg / mL to about 1 mg / mL. In some embodiments, the permeation enhancer is present in the pharmaceutical composition at a concentration of about 0.01 mg / mL to about 25 mg / mL, about 0.2 mg / mL to about 20 mg / mL, about 0.3 mg / mL to about 15 mg / mL, about 0.4 mg / mL to about 12 mg / mL, about 0.5 mg / mL to about 10 mg / mL, or about 1 mg / mL to about 5 mg / mL. In some embodiments, the permeation enhancer is present in the pharmaceutical composition at a concentration of about 1 mg / mL to about 20 mg / mL, about 2 mg / mL to about 15 mg / mL, about 3 mg / mL to about 10 mg / mL, or about 4 mg / mL to about 8 mg / mL. In some embodiments, the permeation enhancer is present in the pharmaceutical composition at a concentration of about 1 mg / mL, about 2 mg / mL, about 3 mg / mL, about 4 mg / mL, about 5 mg / mL, about 6 mg / mL, about 7 mg / mL, about 8 mg / mL, about 9 mg / mL, or about 10 mg / mL. In further embodiments, the permeation enhancer is present in the pharmaceutical composition at a concentration of about 6 mg / mL.

[0119] The pharmaceutical compositions of the present technology may be formulated to deliver a certain dose of the permeation enhancer to a subject. The dose may be based on the body weight of the subject. For example, in some embodiments, the pharmaceutical composition is formulated to deliver the permeation enhancer to the subject at a dose of about 0.1 mg / kg to about 200 mg / kg per body weight of the subject. In some embodiments, the pharmaceutical composition is formulated to deliver a dose of the permeation enhancer of about 0.1 mg / kg to about 175 mg / kg, about 0.25 mg / kg to about 150 mg / kg, about 0.5 mg / kg to about 125 mg / kg, about 0.5 mg / kg to about 100 mg / kg, about 0.75 mg / kg to about 75 mg / kg, about 1 .0 mg / kg to about 60 mg / kg, about 1 .5 mg / kg to about 50 mg / kg, or about 2.0 mg / kg to about 40 mg / kg. In some embodiments, the pharmaceutical composition is formulated to deliver a dose of the permeation enhancer of about 0.1 mg / kg to about 10 mg / kg, about 0.1 mg / kg to about 7.5 mg / kg, about 0.1 mg / kg to about 5 mg / kg, about 0.1 mg / kg to about 2.5 mg / kg, about 0.1 mg / kg to about 2 mg / kg, about 0.1 mg / kg to about 1 .5 mg / kg, or about 0.1 mg / kg to about 1 mg / kg. In some embodiments, the pharmaceutical composition is formulated to deliver a dose of the permeation enhancer of about 1 mg / kg to about 200 mg / kg, about 1 mg / kg to about 150 mg / kg, about 1 mg / kg to about 100 mg / kg,-91 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO about 1 mg / kg to about 50 mg / kg, about 1 mg / kg to about 25 mg / kg, about 1 mg / kg to about 20 mg / kg, about 1 mg / kg to about 15 mg / kg, about 1 mg / kg to about 12 mg / kg, about 1 mg / kg to about 10 mg / kg, or about 1 mg / kg to about 5 mg / kg. In some embodiments, the pharmaceutical composition is formulated to deliver a dose of the permeation enhancer of about 1 mg / kg, about 5 mg / kg, about 10 mg / kg, about 15 mg / kg, 20 mg / kg, about 25 mg / kg, about 30 mg / kg, about 35 mg / kg, about 40 mg / kg, about 45 mg / kg, about 50 mg / kg, about 55 mg / kg, about 60 mg / kg, about 70 mg / kg, about 80 mg / kg, about 90 mg / kg, about 100 mg / kg about 125 mg / kg, about 150 mg / kg, about 175 mg / kg, or about 200 mg / kg. In further embodiments, the pharmaceutical composition is formulated to deliver a dose of the permeation enhancer of about 30 mg / kg.

[0120] In some embodiments, the pharmaceutical composition includes the permeation enhancer in an amount sufficient to deliver about 1.0 mg / kg to about 40 mg / kg of the permeation enhancer to the subject in need thereof. In some embodiments, the permeation enhancer is present in the pharmaceutical composition in an amount of about 10 mg to about 3000 mg. In some embodiments, the permeation enhancer is present in the pharmaceutical composition in an amount of about 25 mg to about 2500 mg, about 50 mg to about 2000 mg, about 100 mg to about 1500 mg, or about 150 mg to about 1000 mg. In some embodiments, the permeation enhancer is present in the pharmaceutical composition in an amount of about 10 mg to about 900 mg, about 15 mg to about 800 mg, about 20 mg to about 700 mg, about 25 mg to about 600 mg, about 30 mg to about 500 mg, about 35 mg to about 400 mg, about 40 mg to about 300 mg, about 45 to about 200 mg, or about 50 mg to about 100 mg. In some embodiments, the permeation enhancer is present in the pharmaceutical composition in an amount of about 100 mg to about 3000 mg, about 150 mg to about 2500 mg, about 200 mg to about 2250 mg, about 250 mg to about 2000 mg, about 300 mg to about 1750 mg, about 350 mg to about 1500 mg, about 400 mg to about 1250 mg, or about 500 mg to about 1000 mg. In some embodiments, the permeation enhancer is present in the pharmaceutical composition in an amount of about 10 mg, about 20 mg, about 30 mg, about 40 mg, about 50 mg, about 60 mg, about 70 mg, about 80 mg, about 90 mg, about 100 mg, about 150 mg, about 200 mg, about 250 mg, about 300 mg, about 350 mg, about 400 mg, about 450 mg, about 500 mg, about 600 mg, about 700 mg, about 800 mg, or about 900 mg. In some embodiments, the permeation enhancer is present in the pharmaceutical-92-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO composition in an amount of about 1000 mg, about 1200 mg, about 1500 mg, about 1700 mg, about 2000 mg, about 2200 mg, about 2500 mg, about 2700 mg, or about 3000 mg.

[0121] In some embodiments, the permeation enhancer is propyl gallate and the propyl gallate is present in the pharmaceutical composition or at a concentration of about 0.1 mg / mL to about 100 mg / mL. In some embodiments, the propyl gallate is present in the pharmaceutical composition at a concentration of about 0.01 mg / mL to about 75 mg / mL, about 0.025 mg / mL to about 50 mg / mL, about 0.05 mg / mL to about 40 mg / mL, about 0.075 mg / mL to about 30 mg / mL, or about 0.1 mg / mL to about 25 mg / mL. In some embodiments, the propyl gallate is present in the pharmaceutical composition at a concentration of about 0.01 mg / mL to about 10 mg / mL, about 0.1 mg / mL to about 7.5 mg / mL, about 0.1 mg / mL to about 5 mg / mL, about 0.1 mg / mL to about 2.5 mg / mL, about 0.1 mg / mL to about 2 mg / mL, about 0.1 mg / mL to about 1.5 mg / mL, or about 0.1 mg / mL to about 1 mg / mL. In some embodiments, the propyl gallate is present in the pharmaceutical composition at a concentration of about 0.01 mg / mL to about 25 mg / mL, about 0.2 mg / mL to about 20 mg / mL, about 0.3 mg / mL to about 15 mg / mL, about 0.4 mg / mL to about 12 mg / mL, about 0.5 mg / mL to about 10 mg / mL, or about 1 mg / mL to about 5 mg / mL. In some embodiments, the propyl gallate is present in the pharmaceutical composition at a concentration of about 1 mg / mL to about 20 mg / mL, about 2 mg / mL to about 15 mg / mL, about 3 mg / mL to about 10 mg / mL, or about 4 mg / mL to about 8 mg / mL. In some embodiments, the propyl gallate is present in the pharmaceutical composition at a concentration of about 1 mg / mL, about 2 mg / mL, about 3 mg / mL, about 4 mg / mL, about 5 mg / mL, about 6 mg / mL, about 7 mg / mL, about 8 mg / mL, about 9 mg / mL, or about 10 mg / mL. In further embodiments, propyl gallate is present in the pharmaceutical composition at a concentration of about 6 mg / mL.

[0122] In some embodiments, the pharmaceutical composition is formulated to deliver the propyl gallate to the subject at a dose of about 0.1 mg / kg to about 200 mg / kg per body weight of the subject. In some embodiments, the pharmaceutical composition is formulated to deliver a dose of the propyl gallate of about 0.1 mg / kg to about 175 mg / kg, about 0.25 mg / kg to about 150 mg / kg, about 0.5 mg / kg to about 125 mg / kg, about 0.5 mg / kg to about 100 mg / kg, about 0.75 mg / kg to about 75 mg / kg, about 1 .0 mg / kg to about 60 mg / kg, about 1 .5 mg / kg to about 50 mg / kg, or about 2.0 mg / kg to about 40 mg / kg. In some embodiments,-93-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO the pharmaceutical composition is formulated to deliver a dose of propyl gallate of about 0.1 mg / kg to about 10 mg / kg, about 0.1 mg / kg to about 7.5 mg / kg, about 0.1 mg / kg to about 5 mg / kg, about 0.1 mg / kg to about 2.5 mg / kg, about 0.1 mg / kg to about 2 mg / kg, about 0.1 mg / kg to about 1 .5 mg / kg, or about 0.1 mg / kg to about 1 mg / kg. In some embodiments, the pharmaceutical composition is formulated to deliver a dose of propyl gallate of about 1 mg / kg to about 200 mg / kg, about 1 mg / kg to about 150 mg / kg, about 1 mg / kg to about 100 mg / kg, about 1 mg / kg to about 50 mg / kg, about 1 mg / kg to about 25 mg / kg, about 1 mg / kg to about 20 mg / kg, about 1 mg / kg to about 15 mg / kg, about 1 mg / kg to about 12 mg / kg, about 1 mg / kg to about 10 mg / kg, or about 1 mg / kg to about 5 mg / kg. In some embodiments, the pharmaceutical composition is formulated to deliver a dose of the propyl gallate of about 1 mg / kg, about 5 mg / kg, about 10 mg / kg, about 15 mg / kg, 20 mg / kg, about 25 mg / kg, about 30 mg / kg, about 35 mg / kg, about 40 mg / kg, about 45 mg / kg, about 50 mg / kg, about 55 mg / kg, about 60 mg / kg, about 70 mg / kg, about 80 mg / kg, about 90 mg / kg, about 100 mg / kg, about 125 mg / kg, about 150 mg / kg, about 175 mg / kg, or about 200 mg / kg. In further embodiments, the pharmaceutical composition is formulated to deliver a dose of the propyl gallate of about 30 mg / kg.

[0123] In some embodiments, the pharmaceutical composition includes the propyl gallate in an amount sufficient to deliver about 1 .0 mg / kg to about 40 mg / kg of the propyl gallate to the subject in need thereof. In some embodiments, the propyl gallate is present in the pharmaceutical composition in an amount of about 10 mg to about 3000 mg. In some embodiments, propyl gallate is present in the pharmaceutical composition in an amount of about 25 mg to about 2500 mg, about 50 mg to about 2000 mg, about 100 mg to about 1500 mg, or about 150 mg to about 1000 mg. In some embodiments, the propyl gallate is present in the pharmaceutical composition in an amount of about 10 mg to about 900 mg, about 15 mg to about 800 mg, about 20 mg to about 700 mg, about 25 mg to about 600 mg, about 30 mg to about 500 mg, about 35 mg to about 400 mg, about 40 mg to about 300 mg, about 45 to about 200 mg, or about 50 mg to about 100 mg. In some embodiments, the propyl gallate is present in the pharmaceutical composition in an amount of about 100 mg to about 3000 mg, about 150 mg to about 2500 mg, about 200 mg to about 2250 mg, about 250 mg to about 2000 mg, about 300 mg to about 1750 mg, about 350 mg to about 1500 mg, about 400 mg to about 1250 mg, or about 500 mg to about 1000 mg. In some embodiments, the-94-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO propyl gallate is present in the pharmaceutical composition in an amount of about 10 mg, about 20 mg, about 30 mg, about 40 mg, about 50 mg, about 60 mg, about 70 mg, about 80 mg, about 90 mg, about 100 mg, about 150 mg, about 200 mg, about 250 mg, about 300 mg, about 350 mg, about 400 mg, about 450 mg, about 500 mg, about 600 mg, about 700 mg, about 800 mg, or about 900 mg. In some embodiments, the propyl gallate is present in the pharmaceutical composition in an amount of about 1000 mg, about 1200 mg, about 1500 mg, about 1700 mg, about 2000 mg, about 2200 mg, about 2500 mg, about 2700 mg, or about 3000 mg.

[0124] The pharmaceutical compositions of the present technology further comprise water. The water may be water for injection (WFI), sterile water, bacteriostatic water for injection (BWFI), distilled water, bidistilled water, deionized water, deionized distilled water, and reverse osmosis water. In some embodiments, the water present in the pharmaceutical composition is water for injection. In some embodiments, the water present in the pharmaceutical composition is water further comprises a salt, such as, for example, sodium chloride. In some embodiments, the pharmaceutical composition comprises saline.Dosage Units

[0125] The present technology also provides oral dosage units of the pharmaceutical compositions described herein. In some embodiments, the oral dosage units are in the form of any dosage unit suitable for oral administration, such as, for example, a pill, a capsule, a powder, a granule, and a film. The oral dosage units may include any form of delivery of the pharmaceutical compositions to a subject where the pharmaceutical compositions are placed in the mouth of the subject, whether or not the pharmaceutical compositions are swallowed. The oral administration may include buccal and sublingual as well as esophageal administration.

[0126] In some embodiments, the oral dosage unit is a solid oral dosage unit. For example, a solid dosage unit may be in the form of a pill, a capsule, or a powder. In some embodiments, the oral pharmaceutical composition is in the form of a pill. Non-limiting examples of pill formulations include tablets, pellets, caplets, and lozenges. In some embodiments, the pill is in the form of a tablet. The tablet may be prepared in various forms such as, for example, an orally disintegrating tablet, a mucoadhesive tablet, enteric coated-95-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO tablet, gastroresistant tablet, powder-filled capsule, caplet, dispersible tablet, a sublingual tablet, a buccal tablet, a chewable tablet, an effervescent tablet, and a lozenge tablet.

[0127] The solid oral dosage unit may be formulated with one or more excipients to improve administration and deliverability of the pharmaceutical composition. For example, the solid oral dosage unit may include one or more diluents, binders, disintegrants, lubricants, glidants, and coatings. In some embodiments, the solid oral dosage unit is formulated with a coating, such as, for example, and enteric coating.

[0128] In one embodiment, the composition is present in a capsule. In some embodiments, the capsule comprises one or more of a gelatin (e.g., a soft gelatin capsule), hydroxypropyl methylcellulose, pullulan, a sugar or starch derivative (e.g., cellulose derivatives, gelatin, vegetable oils, and polyethylene glycols), carrageenan, a plasticizer (e.g., glycerin or sorbitol), a colorant, a preservative (e.g., potassium sorbate, phenol, benzyl alcohol, meta-cresol, methyl paraben, propyl paraben, octadecyldimethylbenzyl ammonium chloride, benzalkonium halides, hexamethonium chloride, alkyl parabens such as methyl or propyl paraben, catechol, resorcinol, cyclohexanol, and 3-pentanol), an antioxidant (e.g., ascorbic acid, methionine, and vitamin E), or an opacifier (e.g., titanium dioxide). The capsule may be a liquid-filled capsule or a semi-solid-filled capsule, or a solid-filled capsule.

[0129] In some embodiments, the capsule is filled with an aqueous suspension comprising the non-naturally occurring melanocortin receptor analog. In some embodiments, the non-naturally occurring melanocortin receptor analog is suspended in water. In other embodiments, the non-naturally occurring melanocortin receptor analog is suspended in saline.

[0130] The dosage unit may comprise a non-naturally occurring melanocortin analog in any purified form. For example, the non-naturally occurring melanocortin analog present in the dosage unit may be lyophilized, crystallized, spray-dried, or precipitated. In some embodiments, the dosage unit comprises lyophilized non-naturally occurring melanocortin analog. In some embodiments, the dosage unit comprises spray-dried non-naturally occurring melanocortin analog. In some embodiments, the dosage unit comprises crystalized non-naturally occurring melanocortin analog. In some embodiments, the dosage unit comprises precipitated non-naturally occurring melanocortin analog.-96-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOMethods of Administration

[0131] The pharmaceutical compositions comprising the non-naturally occurring melanocortin receptor analog of the present technology may be administered to a subject via oral administration. In some embodiments, the pharmaceutical composition is orally administered to the subject via an oral dosage unit. In some embodiments, the pharmaceutical composition is orally administered to the subject via a tablet or a capsule. In some embodiments, the pharmaceutical composition is orally administered to the subject via a tablet.

[0132] In some embodiments, the pharmaceutical composition comprising the non- naturally occurring melanocortin receptor analog is administered hourly (such as every hour, every 2 hours, every 4 hours, every 8 hours, etc.), once a day, or twice a day. In some embodiments, the non-naturally occurring melanocortin receptor analog is administered every morning, every evening, or every afternoon. In some embodiments, the pharmaceutical composition is orally administered before a meal, after a meal, or with a meal.

[0133] In some embodiments, the pharmaceutical composition comprising the non- naturally occurring melanocortin receptor analog is administered as a dosing regimen comprising once, twice, or three times daily oral administration on a (i) weekly; (ii) every other week; (iii) one week of therapy followed by two, three or four weeks off; (iv) two weeks of therapy followed by one, two, three or four weeks off; (v) three weeks of therapy followed by one, two, three, four or five week off; (vi) four weeks of therapy followed by one, two, three, four or five week off; (vii) five weeks of therapy followed by one, two, three, four or five week off; or (viii) monthly schedule. The (i)-(viii) schedules may be repeated 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 , or 12 times or more. In some embodiments, the pharmaceutical composition is administered so as to deliver various dosages of the non-naturally occurring melanocortin receptor analog during the dosing regimen (e.g., a first dose with an effective amount of 10 mg / kg of the melanocortin receptor analog and a second dose with an effective amount of 5 mg / kg of the melanocortin receptor analog).

[0134] In some embodiments, the pharmaceutical composition is administered once every other day, once every 2 or 3 days, once every third day, once per week, once every-97-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO other week, once every third week, once every month, once every six weeks, once every other month, once every three months, once every six months, or once per year. Administration of the pharmaceutical composition comprising the non-naturally occurring melanocortin receptor analog at any of the dosing frequencies of the present technology may be repeated for a total of at least 2 dosages, at least 3 dosages, at least 4 dosages, at least 5 dosages, at least 10 dosages, at least 15 dosages, at least 20 dosages, at least 30 dosages, at least 40 dosages, at least 50 dosages or more. In some embodiments, the frequency of dosages of the pharmaceutical composition is the same during a treatment regimen. In other embodiments, the frequency of dosages of pharmaceutical composition is different during a treatment regimen. The pharmaceutical composition may be administered even less frequently. Alternatively, the dosage regimen may be decreased or increased from an initial dosing regimen for days, weeks, months, or years. In some embodiments, the dosing regimen is repeated at other intervals.

[0135] In some embodiments, the pharmaceutical composition is administered at least once daily to deliver a dose of the non-naturally occurring melanocortin receptor analog of about 0.001 mg / kg to 25 mg / kg, 0.01 mg / kg to 20 mg / kg, 0.05 mg / kg to 15 mg / kg, 0.075 mg / kg to 10 mg / kg, 0.1 mg / kg to 8 mg / kg, 0.2 mg / kg to 6 mg / kg, 0.3 mg / kg to 4 mg / kg, 0.4 mg / kg to 2 mg / kg, or 0.5 mg / kg to 1 mg / kg per body weight of the subject. In some embodiments, the pharmaceutical composition is administered at least once daily to deliver a dose of the non-naturally occurring melanocortin receptor analog of about 0.5 mg / kg to about 10 mg / kg, about 1 mg / kg to about 7.5 mg / kg, or about 2.5 mg / kg to about 5 mg / kg per body weight of the subject.

[0136] The administration methods described herein may be performed on the subject for at least 1 day, 1 week, 1 month, 3 months, 6 months, 1 year, or 5 years. In some embodiments, the pharmaceutical composition is administered to the subject for at least 1 day, at least 2 days, at least 5 days, at least 6 days, at least 1 week, at least 1 month, at least 2 months, at least 3 months, at least 4 months, at least 5 months, at least 6 months, at least 9 months, at least 1 year, at least 2 years, at least 3 years, at least 4 years, or at least 5 years.-98-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0137] In some embodiments, an administration method described herein is performed on the subject for 1 day, 7 days, 14 days, 21 days, 28 days, 35 days, 40 days, 45 days, 50 days, 60 days, 75 days, 90 days, 100 days, 110 days, or 120 days.

[0138] In some embodiments, the pharmaceutical composition is administered to a subject in a continuous doing schedule. As used herein, a “continuous dosing schedule” is an administration or dosing regimen without dose interruptions, e.g., without days off treatment. Repetition of 21 -day or 28-day treatment cycles without dose interruptions is an exemplary continuous dosing schedule.

[0139] In some embodiments, administration of pharmaceutical composition comprising the non-naturally occurring melanocortin receptor analog comprises delivery of the melanocortin receptor analog across the blood brain barrier. In some embodiments, administration of the pharmaceutical composition comprises delivery of the melanocortin receptor analog across the epithelium. In some embodiments, administration of the pharmaceutical composition comprises delivery of the melanocortin receptor analog across the epithelium and the blood brain barrier. In some embodiments, administration of the pharmaceutical composition comprises delivery of the melanocortin receptor analog through the gastrointestinal tract.

[0140] In some embodiments, the non-naturally occurring melanocortin analogs comprise one or more of the following features (i) blood brain barrier passage, (ii) one or more pharmaceutical-like pharmacokinetic measurements (e.g., a pharmacokinetic measurement of a weight loss agent pharmaceutical or an oral melanocortin agonist pharmaceutical), (iii) degradation resistance; (iv) equipotency (e.g., partial or full agonism) on MC3R and MC4R activity, and (v) are orally available (e.g, oral potency). In some embodiments, the oral potency is greater than a subcutaneous administration potency for an equivalent dose. In some embodiments, the non-naturally occurring melanocortin analogs comprise two or more of (i)-(v). In some embodiments, the non-naturally occurring melanocortin agonists comprise each of (i)-(v).-99-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOPharmacokinetics and Pharmacodynamics

[0141] The non-naturally occurring melanocortin analogs in the pharmaceutical compositions of the present technology exhibit pharmacokinetic (pK) and / or pharmacodynamic (pD) parameters. Such pK and / or pD may be expressed or otherwise determined relative to a control, which, in some instances, may be a non-naturally occurring melanocortin receptor analog in a pharmaceutical composition lacking one or more features of the pharmaceutical compositions of the present technology. For example, the control may be a non-naturally occurring melanocortin receptor analog in a pharmaceutical composition lacking one or more permeation enhancers of the present technology.

[0142] In some embodiments, the pK and / or pD of the non-naturally occurring melanocortin analogs may be assessed using concentration and / or temporal measurements (e.g., Tfinai, Cmax, T1 / 2 (h)), AUG, or T max. In some embodiments, the non-naturally occurring melanocortin analogs have reduced clearance and / or metabolism, increased uptake, absorption, and / or stability, relative to a control.Clearance

[0143] “Clearance” may refer to the elimination, absorption, and / or metabolism of the non-naturally occurring melanocortin analogs in the subject’s plasma. Clearance may be assessed as volume of plasma cleared of the non-naturally occurring melanocortin analogs over time (e.g., mL / min, L / hr, or L / day) and / or may be normalized to body weight of the subject (e.g., mL / min / kg). Reduced clearance may also be represented by an increase in half-life or volume of distribution (Vd). In some embodiments, measuring clearance comprises measuring a terminal elimination rate constant (Az) or an inter-compartmental clearance (Q).

[0144] In some embodiments, the reduction in clearance comprises a measurement about 10 minutes, 20 minutes, 30 minutes, 40 minutes, 50 minutes, 1 hour, 1.5 hours, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours, 12 hours, 1 day, 2 days, 3 days, 4 days, 5 day, 6 days, or 1 week after oral administration of the non-naturally occurring melanocortin receptor analog.-100-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0145] In some embodiments, the reduction in clearance comprises a measurement during oral administration of the non-naturally occurring melanocortin receptor analog. In some embodiments, the reduction in clearance comprises a measurement at the completion of oral administration of the non-naturally occurring melanocortin receptor analog.Concentration

[0146] In some embodiments, oral administration of the pharmaceutical compositions of the present technology result in an increased tissue, plasma, and / or serum concentration of the non-naturally occurring melanocortin receptor analog relative to a control. “Concentration” may comprise a measurement reflecting one or more of the absolute amounts of the non-naturally occurring melanocortin receptor analog, the absorption of the non-naturally occurring melanocortin receptor analog, the metabolism of non-naturally occurring melanocortin receptor analog, or the elimination of non-naturally occurring melanocortin receptor analog.

[0147] The increased tissue, plasma, and / or serum concentration may be an increase in concentration of the non-naturally occurring melanocortin receptor analog at a given time point relative to a control administered at the same dose and measured at the same time point. The concentration may be measured at an intermediate time point or a final time point and may be measured as a mean residence time (MRT), an average concentration (Cavg), a trough concentration (Ctrough), or a concentration at the end of administration (e.g., infusion) time (CT).

[0148] In some embodiments, the increased concentration is reflected by an increase in peak plasma concentration (Cmax). An increase in Cmax may suggest increased absorption, reduced metabolism, or slower elimination of the non-naturally occurring melanocortin analogs, relative to a control. In some embodiments, Cmax comprises a dose normalized Cmax (DNC max).

[0149] In some embodiments, the increased concentration is reflected by an increase in minimum plasma concentration (Cmin). An increase in Cmin may suggest increased absorption, reduced metabolism, or slower elimination of the non-naturally occurring-101 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO melanocortin analogs, relative to a control. In some embodiments, Cmin comprises a dose normalized Cmin (DNCmin) .

[0150] In some embodiments, the increased concentration is reflected by a reduction in time to reach Cmax (Tmax). A reduced Tmax may suggest increased absorption, reduced metabolism, or slower elimination of the non-naturally occurring melanocortin analogs, relative to a control.

[0151] In some embodiments, the increased concentration is reflected by a final measurable concentration (Tfinai). An increased Tfinai may suggest increased absorption, reduced metabolism, or slower elimination of the non-naturally occurring melanocortin analogs, relative to a control.

[0152] In some embodiments, the increased concentration is reflected by an increase in area under the curve (AUG). An increase in AUG may signify increased exposure to the non-naturally occurring melanocortin analogs and / or may suggest increased absorption, reduced metabolism, or slower elimination of the non-naturally occurring melanocortin analogs, relative to a control. The AUG measurement may comprise an Area Under the Curve for Concentration of Drug in Non-Compartmental Analysis (DNAUC).

[0153] In some embodiments, the increase in tissue, plasma, and / or serum concentration comprises a measurement about 10 minutes, 20 minutes, 30 minutes, 40 minutes, 50 minutes, 1 hour, 1 .5 hours, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours, 12 hours, 1 day, 2 days, 3 days, 4 days, 5 day, 6 days, or 1 week after oral administration of the non- naturally occurring melanocortin receptor analog.

[0154] In some embodiments, the increase in tissue, plasma, and / or serum concentration comprises a measurement at least 10 minutes, 20 minutes, 30 minutes, 40 minutes, 50 minutes, 1 hour, 1 .5 hours, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours, 12 hours, 1 day, 2 days, 3 days, 4 days, 5 day, 6 days, or 1 week after oral administration of the non- naturally occurring melanocortin receptor analog.

[0155] In some embodiments, the increase in tissue, plasma, and / or serum concentration comprises a measurement at least about 10 minutes, 20 minutes, 30 minutes, 40 minutes, 50 minutes, 1 hour, 1.5 hours, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours, 12-102-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO hours, 1 day, 2 days, 3 days, 4 days, 5 day, 6 days, or 1 week after oral administration of the non-naturally occurring melanocortin receptor analog.

[0156] In some embodiments, the increase in tissue, plasma, and / or serum concentration comprises a measurement during oral administration of the non-naturally occurring melanocortin receptor analog.

[0157] In some embodiments, the increase in tissue, plasma, and / or serum concentration comprises a measurement at the completion of oral administration of the non- naturally occurring melanocortin receptor analog.Additional pD and pK Embodiments

[0158] In some embodiments, the pharmaceutical compositions comprising a non- naturally occurring melanocortin receptor analog of the present technology exhibits one or more of the following:(a) an increase in half-life relative to a control;(b) a reduction in clearance relative to a control;(c) an increase in tissue concentration relative to a control;(d) an increase in plasma concentration relative to a control;(e) an increase in serum concentration relative to a control;(f) an increase in distribution relative to a control;(g) an increase in an AUG measurement relative to a control;(h) an increase in a DNAUC measurement relative to a control;(i) an increase in Tfinai relative to a control;(j) an increase in Cmax relative to a control;(k) an increase in Cmin relative to a control;(l) an increase in DNCmin relative to a control;(m) an increase in MRT relative to a control;(n) an increase in Cavg relative to a control;-103-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO(o) an increase in Ctrough relative to a control;(p) an increase in CT relative to a control;(q) an increase in Vd relative to a control;(r) a reduction in Tmax relative to a control; or(s) a reduction in Q relative to a control.

[0159] In some embodiments, the pharmaceutical compositions comprising a non- naturally occurring melanocortin receptor analog of the present technology exhibits one or more of the following, relative to a control:(a) an increase in half-life by at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 150%, 200%, 250%, 300%, 350%, 400%, 450%, 500%, 600%, 700%, 800%, 900%, or 1000% relative to a control;(b) a reduction in clearance by at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, or 100% relative to a control;(c) an increase in tissue concentration by at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 150%, 200%, 250%, 300%, 350%, 400%, 450%, 500%, 600%, 700%, 800%, 900%, or 1000% relative to a control;(d) an increase in plasma concentration by at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 150%, 200%, 250%, 300%, 350%, 400%, 450%, 500%, 600%, 700%, 800%, 900%, or 1000% relative to a control;(e) an increase in serum concentration by at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 150%, 200%, 250%, 300%, 350%, 400%, 450%, 500%, 600%, 700%, 800%, 900%, or 1000% relative to a control;(f) an increase in distribution by at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 150%, 200%, 250%, 300%, 350%, 400%, 450%, 500%, 600%, 700%, 800%, 900%, or 1000% relative to a control;-104-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO(g) an increase in an AUG by at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 150%, 200%, 250%, 300%, 350%, 400%, 450%, 500%, 600%, 700%, 800%, 900%, or 1000% measurement relative to a control;(h) an increase in a DNAUC measurement by at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 150%, 200%, 250%, 300%, 350%, 400%, 450%, 500%, 600%, 700%, 800%, 900%, or 1000% relative to a control;(i) an increase in Tfinai by at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 150%, 200%, 250%, 300%, 350%, 400%, 450%, 500%, 600%, 700%, 800%, 900%, or 1000% relative to a control;(j) an increase in Cmax by at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 150%, 200%, 250%, 300%, 350%, 400%, 450%, 500%, 600%, 700%, 800%, 900%, or 1000% relative to a control;(k) an increase in Cmin by at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 150%, 200%, 250%, 300%, 350%, 400%, 450%, 500%, 600%, 700%, 800%, 900%, or 1000% relative to a control;(l) an increase in DNCmin by at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 150%, 200%, 250%, 300%, 350%, 400%, 450%, 500%, 600%, 700%, 800%, 900%, or 1000% relative to a control;(m) an increase in MRT by at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 150%, 200%, 250%, 300%, 350%, 400%, 450%, 500%, 600%, 700%, 800%, 900%, or 1000% relative to a control;(n) an increase in Cavg by at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 150%, 200%, 250%, 300%, 350%, 400%, 450%, 500%, 600%, 700%, 800%, 900%, or 1000% relative to a control;(o) an increase in Ctrough by at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 150%, 200%, 250%, 300%, 350%, 400%, 450%, 500%, 600%, 700%, 800%, 900%, or 1000% relative to a control;-105-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO(p) an increase in CT by at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 150%, 200%, 250%, 300%, 350%, 400%, 450%, 500%, 600%, 700%, 800%, 900%, or 1000% relative to a control;(q) an increase in Vd by at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 150%, 200%, 250%, 300%, 350%, 400%, 450%, 500%, 600%, 700%, 800%, 900%, or 1000% relative to a control;(r) a reduction in Tmax by at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, or 100% relative to a control; or(s) a reduction in Q by at least about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, or 100% relative to a control.

[0160] In some embodiments, the pharmaceutical compositions of the present technology increase a concentration of a non-naturally occurring melanocortin receptor analog in the plasma and / or tissue of a subject, relative to a control.EXAMPLES

[0161] The following examples are intended to illustrate various embodiments of the present technology. As such, the specific embodiments discussed are not to be construed as limitations on the scope of the present technology. It will be apparent to one skilled in the art that various equivalents, changes, and modifications may be made without departing from the scope of present technology, and it is understood that such equivalent embodiments, are to be included herein. Further, all references cited herein are hereby incorporated by reference in their entirety, as if fully set forth herein.Example 1: Peptide Synthesis-Generic

[0162] The non-naturally occurring melanocortin analogs of the present technology were synthesized by conventional procedures (e.g., solution-phase procedure, solid-phase synthesis) for the formation of a peptide linkage between amino acids. The solution-phase procedure involved a condensation between the free alpha amino group of an amino acid or derivative thereof having the carboxyl group or other reactive groups protected and the free primary carboxyl group of another amino acid or derivative thereof having the amino group-106-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO or other reactive groups protected. The solid-phase synthesis utilized a variety of resins and reagents and may involve additional purification steps.

[0163] The process for synthesizing the non-naturally occurring melanocortin analogs was generally performed by a procedure as follows. Each amino acid in the desired sequence of the non-naturally occurring melanocortin analogs was added one at a time in succession to another amino acid or derivative thereof or by a procedure whereby peptide fragments with the desired amino acid sequence were first synthesized conventionally and then condensed to provide the desired peptide. In most cases, the resulting peptide was then cyclized to yield a cyclic peptide.

[0164] Solid-phase peptide synthesis was carried out by sequentially incorporating the desired amino acid residues one at a time into the growing peptide chain coupled to a solidphase support according to the general principles of solid phase methods (see Merrifield, Angew Chem. 24:799-810 (1985) and Barany et al., The Peptides, Analysis, Synthesis and Biology, Vol. 2, Gross E. and Meienhofer J., Eds. Academic Press 1 -284 (1980)). An exemplary solid-phase synthesis of non-naturally occurring melanocortin analogs is provided below.

[0165] Initially, the C-terminal amino acid residue of the non-naturally occurring melanocortin analog was coupled to a support, e.g., a solid-phase or tag support. Coupling of the C-terminal amino acid residue and the solid-phase support may be carried out according to any method know in the art. Depending on the coupling method, the alphaamine of the C-terminal amino acid residue may or may not be protected with an amine protecting group, as described below. Likewise, the carboxyl group of the amino acid residue may or may not be activated prior to coupling to the solid-phase support in order to increase its electrophilicity. Some methods of coupling rely on the formation of an ester bond between the carboxyl group of the amino acid and a reactive handle on the solid-phase resin. For example, an amino acid residue may be coupled to a p-benzyloxybenzyl alcohol resin (Wang) or a 2-chlorotrityl chloride resin via an ester linkage. Some methods of coupling rely on the formation of an aminde bond between the carboxyl group of the amino acid and a reactive handle on the solid-phase resin For example, an amino acid residue may be coupled to a benzhydrylamine (BHA) resin through an Fmoc-linker such as, for example, p--107-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO[(R,S)-a-[1 -(9H-fluor-en-9-yl)-methoxyformamido]-2,4-dimethyloxybenzyl]-phenoxyacetic acid (Rink linker) via an amide linkage.

[0166] The non-naturally occurring melanocortin analog was then synthesized by sequential amino acid addition or combination of peptide fragments. Subsequently, the peptide was cleaved from the solid-phase support and purified by methods known in the art, such as, for example, reverse phase high performance liquid chromatography (RP-HPLC) using a suitable column, such as a C18 column, or crystallization. Additionally, or alternatively, other methods of separation or purification were employed, including, but not limited to, methods based on the size or charge of the peptide. Once purified, the peptide was characterized by methods such as high-performance liquid chromatograph (HPLC), amino acid analysis, mass spectrometry, and the like.Example 2: Peptide Synthesis-Protecting Groups

[0167] During synthesis of the non-naturally occurring melanocortin analogs, reactive side chain groups of the various amino acid residues were protected with suitable protecting groups, which prevented undesirable chemical reaction from occurring at that site until the protecting group was removed.

[0168] Additionally, protection of the alpha amino group of an amino acid residue or fragment was performed while that entity reacting with the carboxyl group, followed by the selective removal of the alpha amino protecting group to allow a subsequent reaction to take place at that site. Specific protecting groups for solid phase synthesis methods and solution phase synthesis methods are known to those having ordinary skill in the art. Alpha amino groups were protected by a suitable protecting group, including a urethane-type protecting group, such as benzyloxycarbonyl (Z) and substituted benzyloxycarbonyl, such as p- chlorobenzyloxycarbonyl, p-nitrobenzyloxycarbonyl, p-bromobenzyloxycarbonyl, p- biphenyl-isopropoxycarbonyl, 9-fluorenylmethoxycarbonyl (Fmoc) and p- methoxybenzyloxycarbonyl (Moz); aliphatic urethane-type protecting groups, such as t- butyloxycarbonyl (Boc), diisopropylmethoxycarbonyl, isopropoxycarbonyl, and allyloxycarbonyl. Fmoc was also used for alpha amino protection. Guanidino groups, if present, were protected by a suitable protecting group, such as nitro, p-toluenesulfonyl (Tos), Z, pentamethylchromanesulfonyl (Pmc), adamantyloxycarbonyl,-108-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO pentamethyldihydrobenzofuran-5-sulfonyl (Pbf) and Boc. Pmc was used as a protecting group for Arg.

[0169] Alpha aminoprotecting groups may be removed under basic conditions, such as, for example, using a solution of piperidine, piperazine, diethylamine, or morpholine (20- 40% v / v) in N,N-dimethylformamide (DMF). In synthesis methods in which alpha amino protecting groups were used, protecting groups were removed after synthesis of the peptide and before or after cleavage of the solid-phase support.Example 3: Peptide Synthesis-Additional Modifications

[0170] If necessary, the peptides were further modified to obtain N-terminus modifications, such as acetylation, while on resin, or were removed from the resin by use of a cleaving reagent and then modified. Likewise, C-terminus modification (e.g., amidation), was performed if needed.

[0171] Additionally, the cyclized peptide structures were obtained prior to cleavage from the peptide resin. For cyclization through reactive side chain moieties, the desired side chains were deprotected, and the peptide suspended in a suitable solvent and a cyclic coupling agent added. Suitable solvents, for example DMF, dichloromethane (DCM) or 1 - methyl-2-pyrrolidone (NMP), were used for the cyclization. Suitable cyclic coupling reagents (e.g., 2-(1 H-benzotriazol-1 -yl)-1 ,1 ,3,3-tetramethyluronium tetrafluoroborate (TBTU), 2-(1 H- benzotriazol-1 -yl)-1 ,1 ,3,3-tetramethyluronium hexafluorophosphate (HBTU), benzotriazole- 1 -yl-oxy-tris(dimethylamino)phosphoniumhexafluorophosphate (BOP), benzotriazole-1 -yl- oxy-tris(pyrrolidino)phosphoniumhexafluorophosphate (PyBOP), 2-(7-aza-1 H-benzotriazol- 1 -yl)-1 ,1 , 3, 3-tetramethyluronium tetrafluoroborate (TATU), 2-(2-oxo-1 (2H)-pyridyl)-1 ,1 ,3,3- tetramethyluronium tetrafluoroborate (TPTU), N,N'-dicyclohexylcarbodiimide / 1 - hydroxybenzotriazole (DCCI / HOBt)) were also used for the cyclization. Coupling was initiated by a suitable base, such as N,N-diispropylethylamine (DIPEA), sym-collidine or N- methylmorpholine (NMM).Example 4: Biological Data

[0172] The agonist and antagonist activity of exemplary non-naturally occurring melanocortin analogs at the melanocortin receptors (e.g., MC1 R, MC3R, MC4R, and MC5R)-109-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO were measured via cAMP accumulation assay, according to the following procedure. Experimental design and execution were conducted by Epics Therapeutics S.A. EuroscreenFast (Bruxelles, Belgium).Compound Handing

[0173] Compounds were delivered as powder (1 mg) or 10 mM solutions (100 pl) in 100% DMSO. Powders were solubilized in 100% DMSO at a concentration of 10 mM (master solution) in a defined solvent volume. Serial dilutions were performed from master solution in 100% DMSO to obtain intermediate concentrations 200-, 300- or 400-fold higher than the concentrations to be tested, depending on the assay. Each sample was diluted 100- fold in the assay buffer and dispensed in a test plate. Amounts, solvents, and dilutions were estimated based on standard small-molecule drugs. Cell lines used for functional assays are shown in Table 1 .Table 1. Cell linesCompound Testing

[0174] Compounds were tested for (i) agonist and / or antagonist activity at the human MC3 (FAST-0232C) and MC4 (FAST-0233C) receptors, (ii) agonist activity at the human MC1 (FAST-0232C) receptor, and / or (iii) agonist activity at the human MC5 (FAST-0233C) receptor at the following nanomolar concentrations, in duplicate: 0.0001 , 0.001 , 0.01 , 0.03, 0.1 , 0.3, 1 , 10, 100, and 1 ,000.Testing Protocol

[0175] Cyclic AMP (cAMP) Homogenous Time-Resolved Fluorescence (HTRF) assay for Gs coupled receptor:-110-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0176] CHO-K1 cells expressing recombinant human receptor grown prior to the test in media without antibiotic were detached by gentle flushing with PBS-EDTA (5 mM EDTA), recovered by centrifugation and resuspended in assay buffer (KRH: 5 mM KCI, 1.25 mM MgSO4, 124 mM NaCI, 25 mM HEPES, 13.3 mM Glucose, 1.25 mM KH2PO4, 1.45 mM CaCI2, 0.5 g / l BSA, supplemented with 1 mM IBMX or 25pM Rolipram).

[0177] Dose response curves were performed in parallel with the reference compounds.

[0178] For agonist test (384well): 5 pl of cells were mixed with 5 pl of the test compound at increasing concentrations and then incubated 30 min at room temperature. After addition of the lysis buffer containing cAMP-d2 and anti-cAMP cryptate detection reagents, plates were incubated 1 -hour at room temperature, and fluorescence ratios were measured according to the manufacturer specification, with the HTRF kit.

[0179] For antagonist test (384well): 5 pl of cells were mixed in the wells of an assay plate with 5 pl of a mix of test compound at increasing concentrations and reference agonist for a final concentration corresponding to the historical EC80. The plates were then incubated 30 min at room temperature. After addition of the lysis buffer containing cAMP-d2 and anti-cAMP cryptate detection reagents, plates were incubated 1 -hour at room temperature, and fluorescence ratios were measured according to the manufacturer specification, with the HTRF kit.Quality Control for Compound Testing

[0180] On each day of experimentation and prior to the testing of compounds, reference compounds were tested at several concentrations in duplicate (n=2) to obtain a dose-response curve and an estimated EC50 and / or IC50 values.

[0181] Reference values thus obtained for the test were compared to historical values obtained from the same receptor and used to validate the experimental session.

[0182] A session was considered as valid only if the reference value was found to be within a 0.5 logs interval from the historical value.-111 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0183] For replicate determinations, the maximum variability tolerated in the test was of + / -20% around the average of the replicates.Non-naturally Occurring Melanocortin Analog Grouping

[0184] Group A included non-naturally occurring melanocortin analogs A1 to A29, all of which are cyclic peptides comprising the motif Pro-dNal(2’)-Arg-Trp, or a derivative thereof. Derivatives of the motif having SEQ ID NO: may include substitution of Pro for another amino acid, for example, dlle, dVal, His, or dAla, or Arg for another amino acid. Group A non-naturally occurring melanocortin analogs are provided in Table 2.Table 2. Group A non-naturally occurring melanocortin analogs-112-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0185] Group B included non-naturally occurring melanocortin analogs B1 to B12, all of which are cyclic peptides comprising the motif Pro-dNal(2’)-Arg-Trp. Group B melanocortin analogs may be cyclized through a bond other than a lactam bond between Asp and Lys. Group B non-naturally occurring melanocortin analogs are provided in Table 3.Table 3. Group B non-naturally occurring melanocortin analogs-113-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0186] Group C included non-naturally occurring melanocortin analogs C1 to 013, all of which are cyclic peptides comprising the motif Trp-Pro-dPhe-Arg-Trp (SEQ ID NO: 444) or a derivative thereof. Derivatives of the motif having SEQ ID NO: 120 may include substitution of Pro for another amino acid, for example, dLeu or dVal, or substitution of Trp for another amino acid, for example, Phe, dHis, or dNal(1 ’). Group C non-naturally occurring melanocortin analogs are provided in Table 4.Table 4. Group C non-naturally occurring melanocortin analogs

[0187] Group D included non-naturally occurring melanocortin analogs D1 to D3, all of which are cyclic peptides comprising the motif Cys-dNal(2')-Arg-Trp or a derivative thereof. Derivatives of the motif Cys-dNal(2')-Arg-Trp may include substitution of dNal(2’) for another-114-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO amino acid, for example, Phe, substitutions of Cys for another sulfur-containing amino acid, such as, for example, dCys, Pen, or dPen, and / or rearrangement of the Arg residue. Group D non-naturally occurring melanocortin analogs are provided in Table 5.Table 5. Group D non-naturally occurring melanocortin analogs

[0188] Group E included non-naturally occurring melanocortin analogs E1 to E5, all of which are cyclic peptides comprising the motif Arg-p(l)dPhe-Arg-Tic or a derivative thereof. Derivatives of the motif Arg-p(l)dPhe-Arg-Tic may include substitution of p(l)dPhe for another amino acid, for example, dBip. Group E non-naturally occurring melanocortin analogs are provided in Table 6.Table 6. Group E non-naturally occurring melanocortin analogs-115-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0189] Group F included non-naturally occurring melanocortin analogs F1 -F30, all of which are cyclic peptides comprising the motif Pro-dPhe-Arg-Trp (SEQ ID NO: 445) or a derivative thereof. Derivatives of the motif having SEQ ID NO: may include substitution of Pro for another amino acid, for example, dGIn, dPhe, or dBip, and / or substitution of dPhe for another aromatic amino acid, for example, p(CI)dPhe, p(F)dPhe, or p(Br)dPhe. Group F non-naturally occurring melanocortin analogs are provided in Table 7.Table 7. Group F non-naturally occurring melanocortin analogs-116-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0190] Group G included non-naturally occurring melanocortin analogs G1 to G14, all of which are cyclic peptides comprising the motif Pro-dNal(2’)-Arg-Trp, or a derivative thereof. Derivatives of the motif having SEQ ID NO: may include rearrangement of Arg, Trp, and Pro, or substitution of Pro for a dipeptide, such as, for example, Trp-Pro, Pro-Glu, or Glu-His. Group G non-naturally occurring melanocortin analogs are provided in Table 8.Table 8. Group C non-naturally occurring melanocortin analogs-117-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAgonist activity of melanocortin analogs on melanocortin 1 and 5 receptors

[0191] Administration of some non-naturally occurring melanocortin analogs activated melanocortin 1 receptor (MC1 R) and / or melanocortin 5 receptor (MC5R) activity, as measured by cAMP levels (Table 9).Table 9. Dose-response results of melanocortin analogs and control against the melanocortin 1 receptor (MC1 R) and the melanocortin 5 receptor-118-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO-119-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO-120-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO*** = < 1 nM** = 1 nM to 100 nM* = > 100 nMA — > 80% EmaxB = 50 - 80% EmaxC = < 50% EmaxAgonist activity of melanocortin analogs on melanocortin 3 receptor and melanocortin 4 receptor

[0192] Administration of all the non-naturally occurring melanocortin analogs activated melanocortin 3 receptor (MC3R) and melanocortin 4 receptor (MC4R) activity, as measured by cAMP levels (Table 10).-121 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOTable 10. Dose-response results of melanocortin analogs and control against the melanocortin 3 receptor (MC3R) and melanocortin 4 receptor (MC4R) in agonist mode-122-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO-123-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO-124-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO** = 1 nM to 100 nM* = > 100 nMA — > 80% EmaxB = 50 - 80% EmaxC = < 50% EmaxAntagonist activity of melanocortin analogs on melanocortin 3 receptor and melanocortin 4 receptor

[0193] Administration of some of the non-naturally occurring melanocortin analogs substantially inhibited melanocortin 3 receptor (MC3R) and / or melanocortin 4 receptor (MC4R) activity, as measured by cAMP levels (Table 11 ).Table 11. Dose-response results of melanocortin analogs and control against the melanocortin 3 receptor (MC3R) and melanocortin 4 receptor (MC4R) in antagonist mode-125-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO-126-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO-127-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO*** = < 1 nM** = 1 nM to 100 nM* = > 100 nMA — > 80% EmaxB = 50 - 80% EmaxC = < 50% EmaxExample 5: Assessing Oral BioavailabilitvTCMCB07 (Ac-Nle-c[Asp-Pro-dNal(2’)-Arg-Trp-Lys]-dVal-dPro-NH2; SEQ ID NO: 2)

[0194] To assess the oral bioavailability of TCMCB07, in vitro assays were performed to evaluate absorption and stability. TCMCB07 levels were first assessed for stability in human plasma, simulated gastric fluid (SGF), and simulated intestinal fluid (SIF) over a 120- minute incubation period (FIG. 1 ).-128-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0195] TCMCB07 plasma concentration was next measured following oral administration in cynomolgus monkeys at 30.0 mg / kg (FIG. 2), the results of which are shown in Table 12. TCMCB07 plasma concentration in male and female-divided cynomolgus monkeys at the same concentration or oral administration are shown in Table 13.Table 12. Pharmacokinetics of TCMCB07 (ng / mL)ND = Not determinedBQL = Below the lower limit of quantitation (LLOQ)-129-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOTable 13. TCMCB07 Plasma Concentration in Male and Female Monkeys-130-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO-131 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO-132-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0196] TCMCB07 plasma concentration was further assessed in Beagle dogs and Cynomolgus monkeys following oral administration (Table 14). This showed that TCMCB07 was detectable in the plasma across species after oral administration.Table 14. TCMCB07 Administration in Different Species - Plasma Levels-133-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOCompound A (Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dPro-NH2; SEQ ID NO: 3)

[0197] To assess the oral bioavailability of Compound A (Ac-Nle-c(Asp-Pro-dNal(2')- Arg-Trp-Lys)-dArg-dPro-NH2; SEQ ID NO: 3), plasma concentration of Compound A was measured following oral administration in cynomolgus monkeys at 30.0 mg / kg (FIG. 3), the results of which are shown in Table 15.Table 15. Compound A PharmacokineticsND = Not determined (Parameters not determined due to inadequately defined termina elimination phase).-134-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOBQL = Below the lower limit of quantitation (LLOQ).If the adjusted rsq (linear regression coefficient of the concentration value on the terminal phase) is less than 0.9, T1 / 2 might not be accurately estimated.If the % AUCExtra > 20%, AUCo-inf, Cl, MRTo-inf and Vdss might not be accurately estimated.If the % AUMCExtra > 20%, MRTo-inf and Vdss might not be accurately estimated.**The adjusted linear regression coefficient of the concentration value on the terminal phase is less than 0.9, T1 / 2 might not be accurately estimated.

[0198] As shown in FIG. 3, monkeys orally administered 30 mg / kg Compound A exhibited plasma concentrations above 10 ng / mL at 8 hours after administration.Comparison of TCMCB07 and Compound A

[0199] The antagonist activity of TCMCB07 and Compound A on the melanocortin 3 and 4 receptors as measured by cAMP activity is shown in Table 16.Table 16. Antagonist activity of TCMCB07 and Compound A

[0200] As can be seen, Compound A has improved in vitro cAMP signaling potency compared to TCMCB07, a known potent MC3 / 4R antagonist. Additionally, FIG. 4, which provides side-by-side plasma concentrations of TCMCB07 and compound A, shows that Compound A has improved PO CPK exposure compared to TCMCB07.A07D (Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2; SEQ ID NO: 4)

[0201] Additionally, oral formulations of A07D (Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]- dVal-dPro-NH2; SEQ ID NO: 4) without formulation enhancers were also assessed in male cynomolgus monkeys. Cynomolgus monkeys were orally administered 10 mg / kg or 30 mg / kg A07D in accordance with procedures of the present technology. Plasma concentrations up to 24 hours after administration are shown in FIGS. 5A and 5B.-135-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0202] Various pharmacokinetic parameters of A07D were assessed in the plasma of male cynomolgus monkeys fasted prior to dosing A07D at 10 mg / kg and 30 mg / kg orally. Results are shown in Table 17 and FIG. 5A.Table 17. Oral Bioavailability Data for Exemplary Melanocortin Analog A07D-136-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOND = Not determined (Parameters not determined due to inadequately defined termina elimination phase).BQL = Below the lower limit of quantitation (LLOQ).If the adjusted rsq (linear regression coefficient of the concentration value on the terminal phase) is less than 0.9, T1 / 2 might not be accurately estimated.If the % AUCExtra > 20%, AUCo-inf, Cl, M RTo-inf and Vdss might not be accurately estimated.If the % AUMCExtra > 20%, MRTo-inf and Vdss might not be accurately estimated.The adjusted linear regression coefficient of the concentration value on the terminal phase is less than 0.9, T1 / 2 might not be accurately estimated. a: Bioavailability (%) was calculated using AUCo-inf (if all AUCExtra 20%) or AUCo-iast (if one or more AUCExtra > 20%) with Nominal Dose.03 (Ac-dLys-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dLys-dVa!-dPro-NH2; SEQ ID NO: 5)

[0203] Plasma concentration of 03 (Ac-dLys-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dLys-dVal- dPro-NH2; SEQ ID NO: 5) were next assessed up to 24 hours following oral administration to cynomolgus monkeys at 10 mg / kg or 30 mg / kg, results of which are shown in FIG. 5B. As show in FIG. 5B, the oral bioavailability of low doses of 03, with plasma concentrations of greater than 10 ng / mL of 03 up to 8 hours after oral administration. Additionally, monkeys-137-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO administered 03 at 30 mg / kg doses exhibited plasma concentration of at least about 5 ng / mL up to 24 hours after oral administration.Additional Embodiments

[0204] Various embodiments of the present technology are set forth below in paragraphs

[0205] to

[0278] :

[0205] 1. An orally deliverable pharmaceutical composition comprising a non- naturally occurring melanocortin analog, the non-naturally occurring melanocortin analog comprising a sequence of Formula (I):X1-X2-X3- R1- R2- R3- R4- R5- R6- R7- Y1- Y2-Y3- Y4( I ) , wherein:X1is absent, D-valine (dVal), or norleucine (Nle);X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of aspartic acid (Asp), Nle, D- norleucine (dNIe), hisitdine (His), D-histidine (dHis), D-phenylalanine (dPhe), arginine (Arg), D-arginine (dArg) and D-proline (dPro);R2is selected from the group consisting of Asp, proline (Pro), lysine (Lys), cysteine (Cys), D-cysteine (dCys), D-penicillamine (dPen), penicillamine (Pen), glutamic acid (Glu), and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, dPro, tryptyl-proline (Trp-Pro), tryptyl-D-leucine (Trp-dLeu), trytpyl-D-valine (Trp-dVal), D-isoleucine (dlle), D- alanine (dAla), D-methionine (dMet), glycine (Gly), glycyl-glycine (Gly-Gly), beta-alanine (p- Ala), 3-aminomethyl-benzoic acid (Mamb), 1 -amino-1 -cyclopentane carboxylic (Cpe), 1 - amino-1 -cyclohexanecarboxylic acid (Che), 1 -aminocyclo-propane-1 -carboxylic acid (Acpc), prolyl-proline (Pro-Pro), prolyl-hisitdine (Pro-His), phenylalanyl-proline (Phe-Pro), D-histidyl- proline (dHis-Pro), hydroxy proline (Hyp), prolyl-glutamic acid (Pro-Glu), glutamic acid- histidine (Glu-His), Arg, dPhe, biphenylalanine (Bip), D-biphenylalanine (dBip), D-tyrosine (dTyr), D-tryptophan (dTrp), leucine (Leu), dLeu, dVal, D-glutamine (dGIn), tryptyl-arginine (Trp-Arg), histidyl-arginine (His-Arg), prolyl-arginine (Pro-Arg), arginyl-proline (Arg-Pro), and alanine (Ala);-138-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOR4is selected from the group consisting of 2’-D-naphthylalanine (dNal(2’)), Bip, dBip, dPhe, para-fluoro-D-phenylalanine (p(F)dPhe), para-chloro-D-phenylalanine (p(CI)dPhe), para-iodo-D-phenylalanine (p(l)dPhe), and para-bromo-D-phenylalanine (p(Br)dPhe);R5is absent or selected from the group consisting of Arg, dArg, D-lysine (dLys), D- ornithine (dOrn), Glu, D-aspartic acid (dAsp), D-glutamic acid (dGlu), Pro, and His;R6is absent or is selected from the group consisting of Trp, tryptyl-glycine (Trp-Gly), tryptyl-proline (Trp-Pro), 2’-naphthylalanine (Nal(2’)), 1 ’-naphthylalanine (Nal(1 ’)), 1 ’-D- naphthylalanine (dNal(1 ’)), Phe, dPhe, and 1 ,2,3,4-tetrahydroisoquinoline carboxylic acid (Tic);R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, dOrn, and ornthine (Orn);Y1is selected from the group consisting of dVal, D-tert-leucine (dTle), dLys, Asp, D- threonine (dThr), p2-valine (p2Val), p3-valine (p3Val), Nle, Trp, dArg, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, p-proline (pPro), Nle, and valine (Vai);Y3is absent or selected from the group consisting of dVal, dThr, dPro, and Pro;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R1or R2and R7when R1or R2is Asp or CO-cis- CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that: when R4is dNal(2’), then R3is not Pro-His, Hyp, or Pro-Pro, R5is not His, R6is not Phe, dPhe, Nal (1 ’), or dNal(1 ’), and either (i) Y1is dVal, Y2is dPro, and Y3-Y4are absent (ii) Y1is dLys or dArg, and R2is dPen, or (iii) Y1is Nle,-139-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO when R4is p(F)dPhe, then R3is dPhe, dBip, dTyr, dTrp, or Pro, wherein when R3is Pro then either (i) R6is not Trp or (ii) Y1and Y2are each independently dVal or dTle, when R4is p(CI)dPhe, then R3is dPhe, dBip, dTyr, or His, wherein when R3is His then R1is dArg and Y1is dVal, when R4is p(Br)dPhe, then R3is dPhe, Bip, dTyr, dTrp, dGIn, or His, wherein when R3is His then either (i) R1is His or dHis and Y1is dTle or (ii) R2is dCys, when R4is p(l)dPhe, then R3is Arg-Pro, when R4is dBip, then R2is Asp and R3is not Pro, when R4is dNal(2’) and R3is Pro, then R1is absent, dPhe, or Nle and R6is Trp, wherein when R1is absent, then R2is CO-cis-CH=CH-CO, when R1is dPhe, then R2is dPen, and when R1is Nle, then (i) R2is Asp and either (a) R5is not Arg, Pro, or absent, (b) R7is not Lys, or (c) X1-X3are all Nle, (ii) R2and R7are each is dPen or (iii) R2is Pen or Cys, and R7is dCys, when R4is dNal(2’) and R3is Ala, Leu, Gly, or His, then either R2is dPen or R6is Trp-Pro, when R4is dNal(2’) and R3is Glu-His, then R6is Trp, when R4is dNal(2’) and R3is absent, then (i) R2is not Asp, (ii) R2and R7are not both Cys, and (iii) when R2is dCys, then R7is not Pen, when R4is dPhe and R3is Pro, then the N-terminus is acetylated, X1-X2are each independently absent or Nle, X3is absent, R1is dNIe, dPhe or Nle, R2is Cys or Asp, R5is Arg or Pro, R6is Trp or dNal(T), the C-terminus is amidated, wherein when R1is Nle, then either (i) Y1is dVal, Y2is dPro and at least one of X1-X2is Nle, (ii) Y1is dVal or Lys and Y2is dArg or Vai, or (iii) Y1is dLys, Asp, dThr, p2Val, or p3Val, and Y2is not dVal, and when R4is dPhe, and R3is not Pro, then the N-terminus is acetylated, X1-X3are absent, R1is absent, Nle, Arg, or dArg, Y1is dVal, Y2is dPro and Y3-Y4are absent, ad (i) R3is absent and R2or R7is Cys, (ii) R3is Trp-Pro and either (a) R5is His, (b) R6is Nal(1 ’), dNal(1 ’), Phe, or dPhe, or (c) R7is dCys, (iii) R3is Pro-His, R1is Nle and R5is His, (iv) R3is Hyp or dAla and either R1is not Nle or R6is not Trp, (v) R3is His and R5is Pro, or (vi) R3is selected from dBip, Pro-Pro, Arg, dVal, Cpe, Che, Phe-Pro, dHis-Pro, dlle, Trp-Leu, and Trp-dVal.-140-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0206] 2. A pharmaceutical composition comprising a non-naturally occurring melanocortin receptor analog and a permeation enhancer, the non-naturally occurring melanocortin receptor analog comprising a sequence of Formula (I):X1-X2-X3- R1- R2- R3- R4- R5- R6- R7- Y1- Y2-Y3- Y4( I ) , wherein:X1is absent, D-valine (dVal), or norleucine (Nle);X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of aspartic acid (Asp), Nle, D- norleucine (dNIe), hisitdine (His), D-histidine (dHis), D-phenylalanine (dPhe), arginine (Arg), D-arginine (dArg) and D-proline (dPro);R2is selected from the group consisting of Asp, proline (Pro), lysine (Lys), cysteine (Cys), D-cysteine (dCys), D-penicillamine (dPen), penicillamine (Pen), glutamic acid (Glu), and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, dPro, tryptyl-proline (Trp-Pro), tryptyl-D-leucine (Trp-dLeu), trytpyl-D-valine (Trp-dVal), D-isoleucine (dlle), D- alanine (dAla), D-methionine (dMet), glycine (Gly), glycyl-glycine (Gly-Gly), beta-alanine (p- Ala), 3-aminomethyl-benzoic acid (Mamb), 1 -amino-1 -cyclopentane carboxylic (Cpe), 1 - amino-1 -cyclohexanecarboxylic acid (Che), 1 -aminocyclo-propane-1 -carboxylic acid (Acpc), prolyl-proline (Pro-Pro), prolyl-hisitdine (Pro-His), phenylalanyl-proline (Phe-Pro), D-histidyl- proline (dHis-Pro), hydroxy proline (Hyp), prolyl-glutamic acid (Pro-Glu), glutamic acid- histidine (Glu-His), Arg, dPhe, biphenylalanine (Bip), D-biphenylalanine (dBip), D-tyrosine (dTyr), D-tryptophan (dTrp), leucine (Leu), dLeu, dVal, D-glutamine (dGIn), tryptyl-arginine (Trp-Arg), histidyl-arginine (His-Arg), prolyl-arginine (Pro-Arg), arginyl-proline (Arg-Pro), and alanine (Ala);R4is selected from the group consisting of 2’-D-naphthylalanine (dNal(2’)), Bip, dBip, dPhe, para-fluoro-D-phenylalanine (p(F)dPhe), para-chloro-D-phenylalanine (p(CI)dPhe), para-iodo-D-phenylalanine (p(l)dPhe), and para-bromo-D-phenylalanine (p(Br)dPhe);R5is absent or selected from the group consisting of Arg, dArg, D-lysine (dLys), D- ornithine (dOrn), Glu, D-aspartic acid (dAsp), D-glutamic acid (dGlu), Pro, and His;-141 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOR6is absent or is selected from the group consisting of Trp, tryptyl-glycine (Trp-Gly), tryptyl-proline (Trp-Pro), 2’-naphthylalanine (Nal(2’)), 1 ’-naphthylalanine (Nal(1 ’)), 1 ’-D- naphthylalanine (dNal(1 ’)), Phe, dPhe, and 1 ,2,3,4-tetrahydroisoquinoline carboxylic acid (Tic);R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, dOrn, and ornthine (Orn);Y1is selected from the group consisting of dVal, D-tert-leucine (dTle), dLys, Asp, D- threonine (dThr), p2-valine (p2Val), p3-valine (p3Val), Nle, Trp, dArg, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, p-proline (pPro), Nle, and valine (Vai);Y3is absent or selected from the group consisting of dVal, dThr, dPro, and Pro;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R1or R2and R7when R1or R2is Asp or CO-cis- CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that: when R4is dNal(2’), then R3is not Pro-His, Hyp, or Pro-Pro, R5is not His, R6is not Phe, dPhe, Nal (1 ’), or dNal(1 ’), and either (i) Y1is dVal, Y2is dPro, and Y3-Y4are absent (ii) Y1is dLys or dArg, and R2is dPen, or (iii) Y1is Nle, when R4is p(F)dPhe, then R3is dPhe, dBip, dTyr, dTrp, or Pro, wherein when R3is Pro then either (i) R6is not Trp or (ii) Y1and Y2are each independently dVal or dTle, when R4is p(CI)dPhe, then R3is dPhe, dBip, dTyr, or His, wherein when R3is His then R1is dArg and Y1is dVal,-142-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO when R4is p(Br)dPhe, then R3is dPhe, Bip, dTyr, dTrp, dGIn, or His, wherein when R3is His then either (i) R1is His or dHis and Y1is dTle or (ii) R2is dCys, when R4is p(l)dPhe, then R3is Arg-Pro, when R4is dBip, then R2is Asp and R3is not Pro, when R4is dNal(2’) and R3is Pro, then R1is absent, dPhe, or Nle and R6is Trp, wherein when R1is absent, then R2is CO-cis-CH=CH-CO, when R1is dPhe, then R2is dPen, and when R1is Nle, then (i) R2is Asp and either (a) R5is not Arg, Pro, or absent, (b) R7is not Lys, or (c) X1-X3are all Nle, (ii) R2and R7are each is dPen or (iii) R2is Pen or Cys, and R7is dCys, when R4is dNal(2’) and R3is Ala, Leu, Gly, or His, then either R2is dPen or R6is Trp-Pro, when R4is dNal(2’) and R3is Glu-His, then R6is Trp, when R4is dNal(2’) and R3is absent, then (i) R2is not Asp, (ii) R2and R7are not both Cys, and (iii) when R2is dCys, then R7is not Pen, when R4is dPhe and R3is Pro, then the N-terminus is acetylated, X1-X2are each independently absent or Nle, X3is absent, R1is dNIe, dPhe or Nle, R2is Cys or Asp, R5is Arg or Pro, R6is Trp or dNal(T), the C-terminus is amidated, wherein when R1is Nle, then either (i) Y1is dVal, Y2is dPro and at least one of X1-X2is Nle, (ii) Y1is dVal or Lys and Y2is dArg or Vai, or (iii) Y1is dLys, Asp, dThr, p2Val, or p3Val, and Y2is not dVal, and when R4is dPhe, and R3is not Pro, then the N-terminus is acetylated, X1-X3are absent, R1is absent, Nle, Arg, or dArg, Y1is dVal, Y2is dPro and Y3-Y4are absent, ad (i) R3is absent and R2or R7is Cys, (ii) R3is Trp-Pro and either (a) R5is His, (b) R6is Nal(1 ’), dNal(1 ’), Phe, or dPhe, or (c) R7is dCys, (iii) R3is Pro-His, R1is Nle and R5is His, (iv) R3is Hyp or dAla and either R1is not Nle or R6is not Trp, (v) R3is His and R5is Pro, or (vi) R3is selected from dBip, Pro-Pro, Arg, dVal, Cpe, Che, Phe-Pro, dHis-Pro, dlle, Trp-Leu, and Trp-dVal.

[0207] 3. A pharmaceutical composition for oral administration of a non-naturally occurring melanocortin receptor analog, the composition comprising a permeation enhancer and a non-naturally occurring melanocortin receptor analog comprising a sequence of Formula (I):-143-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOX1-X2-X3- R1- R2- R3- R4- R5- R6- R7- Y1- Y2-Y3- Y4( I ) , wherein:X1is absent, D-valine (dVal), or norleucine (Nle);X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of aspartic acid (Asp), Nle, D- norleucine (dNIe), hisitdine (His), D-histidine (dHis), D-phenylalanine (dPhe), arginine (Arg), D-arginine (dArg) and D-proline (dPro);R2is selected from the group consisting of Asp, proline (Pro), lysine (Lys), cysteine (Cys), D-cysteine (dCys), D-penicillamine (dPen), penicillamine (Pen), glutamic acid (Glu), and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, dPro, tryptyl-proline (Trp-Pro), tryptyl-D-leucine (Trp-dLeu), trytpyl-D-valine (Trp-dVal), D-isoleucine (dlle), D- alanine (dAla), D-methionine (dMet), glycine (Gly), glycyl-glycine (Gly-Gly), beta-alanine (p- Ala), 3-aminomethyl-benzoic acid (Mamb), 1 -amino-1 -cyclopentane carboxylic (Cpe), 1 - amino-1 -cyclohexanecarboxylic acid (Che), 1 -aminocyclo-propane-1 -carboxylic acid (Acpc), prolyl-proline (Pro-Pro), prolyl-hisitdine (Pro-His), phenylalanyl-proline (Phe-Pro), D-histidyl- proline (dHis-Pro), hydroxy proline (Hyp), prolyl-glutamic acid (Pro-Glu), glutamic acid- histidine (Glu-His), Arg, dPhe, biphenylalanine (Bip), D-biphenylalanine (dBip), D-tyrosine (dTyr), D-tryptophan (dTrp), leucine (Leu), dLeu, dVal, D-glutamine (dGIn), tryptyl-arginine (Trp-Arg), histidyl-arginine (His-Arg), prolyl-arginine (Pro-Arg), arginyl-proline (Arg-Pro), and alanine (Ala);R4is selected from the group consisting of 2’-D-naphthylalanine (dNal(2’)), Bip, dBip, dPhe, para-fluoro-D-phenylalanine (p(F)dPhe), para-chloro-D-phenylalanine (p(CI)dPhe), para-iodo-D-phenylalanine (p(l)dPhe), and para-bromo-D-phenylalanine (p(Br)dPhe);R5is absent or selected from the group consisting of Arg, dArg, D-lysine (dLys), D- ornithine (dOrn), Glu, D-aspartic acid (dAsp), D-glutamic acid (dGlu), Pro, and His;R6is absent or is selected from the group consisting of Trp, tryptyl-glycine (Trp-Gly), tryptyl-proline (Trp-Pro), 2’-naphthylalanine (Nal(2’)), 1 ’-naphthylalanine (Nal(1 ’)), 1 ’-D- naphthylalanine (dNal(1 ’)), Phe, dPhe, and 1 ,2,3,4-tetrahydroisoquinoline carboxylic acid (Tic);-144-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOR7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, dOrn, and ornthine (Orn);Y1is selected from the group consisting of dVal, D-tert-leucine (dTle), dLys, Asp, D- threonine (dThr), p2-valine (p2Val), p3-valine (p3Val), Nle, Trp, dArg, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, p-proline (pPro), Nle, and valine (Vai);Y3is absent or selected from the group consisting of dVal, dThr, dPro, and Pro;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R1or R2and R7when R1or R2is Asp or CO-cis- CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that: when R4is dNal(2’), then R3is not Pro-His, Hyp, or Pro-Pro, R5is not His, R6is not Phe, dPhe, Nal (1 ’), or dNal(1 ’), and either (i) Y1is dVal, Y2is dPro, and Y3-Y4are absent (ii) Y1is dLys or dArg, and R2is dPen, or (iii) Y1is Nle, when R4is p(F)dPhe, then R3is dPhe, dBip, dTyr, dTrp, or Pro, wherein when R3is Pro then either (i) R6is not Trp or (ii) Y1and Y2are each independently dVal or dTle, when R4is p(CI)dPhe, then R3is dPhe, dBip, dTyr, or His, wherein when R3is His then R1is dArg and Y1is dVal, when R4is p(Br)dPhe, then R3is dPhe, Bip, dTyr, dTrp, dGIn, or His, wherein when R3is His then either (i) R1is His or dHis and Y1is dTle or (ii) R2is dCys, when R4is p(l)dPhe, then R3is Arg-Pro, when R4is dBip, then R2is Asp and R3is not Pro,-145-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO when R4is dNal(2’) and R3is Pro, then R1is absent, dPhe, or Nle and R6is Trp, wherein when R1is absent, then R2is CO-cis-CH=CH-CO, when R1is dPhe, then R2is dPen, and when R1is Nle, then (i) R2is Asp and either (a) R5is not Arg, Pro, or absent, (b) R7is not Lys, or (c) X1-X3are all Nle, (ii) R2and R7are each is dPen or (iii) R2is Pen or Cys, and R7is dCys, when R4is dNal(2’) and R3is Ala, Leu, Gly, or His, then either R2is dPen or R6is Trp-Pro, when R4is dNal(2’) and R3is Glu-His, then R6is Trp, when R4is dNal(2’) and R3is absent, then (i) R2is not Asp, (ii) R2and R7are not both Cys, and (iii) when R2is dCys, then R7is not Pen, when R4is dPhe and R3is Pro, then the N-terminus is acetylated, X1-X2are each independently absent or Nle, X3is absent, R1is dNIe, dPhe or Nle, R2is Cys or Asp, R5is Arg or Pro, R6is Trp or dNal(T), the C-terminus is amidated, wherein when R1is Nle, then either (i) Y1is dVal, Y2is dPro and at least one of X1-X2is Nle, (ii) Y1is dVal or Lys and Y2is dArg or Vai, or (iii) Y1is dLys, Asp, dThr, p2Val, or p3Val, and Y2is not dVal, and when R4is dPhe, and R3is not Pro, then the N-terminus is acetylated, X1-X3are absent, R1is absent, Nle, Arg, or dArg, Y1is dVal, Y2is dPro and Y3-Y4are absent, ad (i) R3is absent and R2or R7is Cys, (ii) R3is Trp-Pro and either (a) R5is His, (b) R6is Nal(1 ’), dNal(1 ’), Phe, or dPhe, or (c) R7is dCys, (iii) R3is Pro-His, R1is Nle and R5is His, (iv) R3is Hyp or dAla and either R1is not Nle or R6is not Trp, (v) R3is His and R5is Pro, or (vi) R3is selected from dBip, Pro-Pro, Arg, dVal, Cpe, Che, Phe-Pro, dHis-Pro, dlle, Trp-Leu, and Trp-dVal.

[0208] 4. A pharmaceutical composition formulated to deliver about 0.1 mg / kg to about 5 mg / kg, per body weight of a subject, of a non-naturally occurring melanocortin receptor analog to the subject, the pharmaceutical composition comprising: a permeation enhancer; and a non-naturally occurring melanocortin receptor analog comprising a sequence of Formula (I):X1-X2-X3- R1- R2- R3- R4- R5- R6- R7- Y1- Y2-Y3- Y4( I ) , wherein:-146-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOX1is absent, D-valine (dVal), or norleucine (Nle);X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of aspartic acid (Asp), Nle, D- norleucine (dNIe), hisitdine (His), D-histidine (dHis), D-phenylalanine (dPhe), arginine (Arg), D-arginine (dArg) and D-proline (dPro);R2is selected from the group consisting of Asp, proline (Pro), lysine (Lys), cysteine (Cys), D-cysteine (dCys), D-penicillamine (dPen), penicillamine (Pen), glutamic acid (Glu), and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, dPro, tryptyl-proline (Trp-Pro), tryptyl-D-leucine (Trp-dLeu), trytpyl-D-valine (Trp-dVal), D-isoleucine (dlle), D- alanine (dAla), D-methionine (dMet), glycine (Gly), glycyl-glycine (Gly-Gly), beta-alanine (p- Ala), 3-aminomethyl-benzoic acid (Mamb), 1 -amino-1 -cyclopentane carboxylic (Cpe), 1 - amino-1 -cyclohexanecarboxylic acid (Che), 1 -aminocyclo-propane-1 -carboxylic acid (Acpc), prolyl-proline (Pro-Pro), prolyl-hisitdine (Pro-His), phenylalanyl-proline (Phe-Pro), D-histidyl- proline (dHis-Pro), hydroxy proline (Hyp), prolyl-glutamic acid (Pro-Glu), glutamic acid- histidine (Glu-His), Arg, dPhe, biphenylalanine (Bip), D-biphenylalanine (dBip), D-tyrosine (dTyr), D-tryptophan (dTrp), leucine (Leu), dLeu, dVal, D-glutamine (dGIn), tryptyl-arginine (Trp-Arg), histidyl-arginine (His-Arg), prolyl-arginine (Pro-Arg), arginyl-proline (Arg-Pro), and alanine (Ala);R4is selected from the group consisting of 2’-D-naphthylalanine (dNal(2’)), Bip, dBip, dPhe, para-fluoro-D-phenylalanine (p(F)dPhe), para-chloro-D-phenylalanine (p(CI)dPhe), para-iodo-D-phenylalanine (p(l)dPhe), and para-bromo-D-phenylalanine (p(Br)dPhe);R5is absent or selected from the group consisting of Arg, dArg, D-lysine (dLys), D- ornithine (dOrn), Glu, D-aspartic acid (dAsp), D-glutamic acid (dGlu), Pro, and His;R6is absent or is selected from the group consisting of Trp, tryptyl-glycine (Trp-Gly), tryptyl-proline (Trp-Pro), 2’-naphthylalanine (Nal(2’)), 1 ’-naphthylalanine (Nal(1 ’)), 1 ’-D- naphthylalanine (dNal(1 ’)), Phe, dPhe, and 1 ,2,3,4-tetrahydroisoquinoline carboxylic acid (Tic);R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, dOrn, and ornthine (Orn);-147-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOY1is selected from the group consisting of dVal, D-tert-leucine (dTle), dLys, Asp, D- threonine (dThr), p2-valine (p2Val), p3-valine (p3Val), Nle, Trp, dArg, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, p-proline (pPro), Nle, and valine (Vai);Y3is absent or selected from the group consisting of dVal, dThr, dPro, and Pro;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R1or R2and R7when R1or R2is Asp or CO-cis- CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that: when R4is dNal(2’), then R3is not Pro-His, Hyp, or Pro-Pro, R5is not His, R6is not Phe, dPhe, Nal (1 ’), or dNal(1 ’), and either (i) Y1is dVal, Y2is dPro, and Y3-Y4are absent (ii) Y1is dLys or dArg, and R2is dPen, or (iii) Y1is Nle, when R4is p(F)dPhe, then R3is dPhe, dBip, dTyr, dTrp, or Pro, wherein when R3is Pro then either (i) R6is not Trp or (ii) Y1and Y2are each independently dVal or dTle, when R4is p(CI)dPhe, then R3is dPhe, dBip, dTyr, or His, wherein when R3is His then R1is dArg and Y1is dVal, when R4is p(Br)dPhe, then R3is dPhe, Bip, dTyr, dTrp, dGIn, or His, wherein when R3is His then either (i) R1is His or dHis and Y1is dTle or (ii) R2is dCys, when R4is p(l)dPhe, then R3is Arg-Pro, when R4is dBip, then R2is Asp and R3is not Pro, when R4is dNal(2’) and R3is Pro, then R1is absent, dPhe, or Nle and R6is Trp, wherein when R1is absent, then R2is CO-cis-CH=CH-CO, when R1is dPhe, then R2is dPen, and when R1is Nle, then (i) R2is Asp and either (a) R5is not Arg, Pro, or absent, (b)-148-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOR7is not Lys, or (c) X1-X3are all Nle, (ii) R2and R7are each is dPen or (iii) R2is Pen or Cys, and R7is dCys, when R4is dNal(2’) and R3is Ala, Leu, Gly, or His, then either R2is dPen or R6is Trp-Pro, when R4is dNal(2’) and R3is Glu-His, then R6is Trp, when R4is dNal(2’) and R3is absent, then (i) R2is not Asp, (ii) R2and R7are not both Cys, and (iii) when R2is dCys, then R7is not Pen, when R4is dPhe and R3is Pro, then the N-terminus is acetylated, X1-X2are each independently absent or Nle, X3is absent, R1is dNIe, dPhe or Nle, R2is Cys or Asp, R5is Arg or Pro, R6is Trp or dNal(1 ’), the C-terminus is amidated, wherein when R1is Nle, then either (i) Y1is dVal, Y2is dPro and at least one of X1-X2is Nle, (ii) Y1is dVal or Lys and Y2is dArg or Vai, or (iii) Y1is dLys, Asp, dThr, p2Val, or p3Val, and Y2is not dVal, and when R4is dPhe, and R3is not Pro, then the N-terminus is acetylated, X1-X3are absent, R1is absent, Nle, Arg, or dArg, Y1is dVal, Y2is dPro and Y3-Y4are absent, ad (i) R3is absent and R2or R7is Cys, (ii) R3is Trp-Pro and either (a) R5is His, (b) R6is Nal(1 ’), dNal(1 ’), Phe, or dPhe, or (c) R7is dCys, (iii) R3is Pro-His, R1is Nle and R5is His, (iv) R3is Hyp or dAla and either R1is not Nle or R6is not Trp, (v) R3is His and R5is Pro, or (vi) R3is selected from dBip, Pro-Pro, Arg, dVal, Cpe, Che, Phe-Pro, dHis-Pro, dlle, Trp-Leu, and Trp-dVal.

[0209] 5. The pharmaceutical composition of any one of embodiments 1 -4, wherein the non-naturally occurring melanocortin receptor analog is present at a concentration of about 0.01 mg / mL to about 200 mg / mL.

[0210] 6. The pharmaceutical composition of any one of embodiments 1 -5, wherein the non-naturally occurring melanocortin receptor analog is present at a concentration of about 0.1 mg / mL to about 100 mg / mL.

[0211] 7. The pharmaceutical composition of any one of embodiments 1 -6, wherein the non-naturally occurring melanocortin receptor analog is present at a concentration of about 0.1 mg / mL to about 5 mg / mL.-149-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0212] 8. The pharmaceutical composition of any one of embodiments 1 -7, wherein the non-naturally occurring melanocortin receptor analog is present in an amount of about 1 .0 mg to about 20 g.

[0213] 9. The pharmaceutical composition of any one of embodiments 1 -8, wherein the non-naturally occurring melanocortin receptor analog is present in an amount of about 10 mg to about 1500 mg.

[0214] 10. The pharmaceutical composition of any one of embodiments 1 -9, wherein the permeation enhancer is present at a concentration of about 0.1 mg / mL to about 25 mg / mL.

[0215] 11. The pharmaceutical composition of any one of embodiments 1 -10, wherein the permeation enhancer is present at a concentration of about 6 mg / mL.

[0216] 12. The pharmaceutical composition of any one of embodiments 1 -11 , wherein the permeation enhancer is present in an amount of about 10 mg to about 3000 mg.

[0217] 13. The pharmaceutical composition of any one of embodiments 1 -12, further comprising water.

[0218] 14. The pharmaceutical composition of any one of embodiments 1 -13, formulated for oral delivery.

[0219] 15. The pharmaceutical composition of embodiment 14, formulated as an oral dosage unit.

[0220] 16. The pharmaceutical composition of embodiment 15, wherein the oral dosage unit is a tablet or a capsule.

[0221] 17. The pharmaceutical composition of embodiment 16, wherein the capsule is a liquid-filled capsule or a semi-solid-filled capsule.

[0222] 18. The pharmaceutical composition of any one of embodiments 1 -17, further comprising an excipient.

[0223] 19. The pharmaceutical composition of embodiment 18, wherein the excipient comprises or consists of an enzyme inhibitor.-150-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO

[0224] 20. The pharmaceutical composition of embodiment 18 or 19, wherein the excipient may comprise one or more compounds which inhibit, bind, or otherwise target an enzyme comprising a phosphatase or a protease.

[0225] 21. The pharmaceutical composition of embodiment 20, wherein the phosphatase is an intestinal phosphatase.

[0226] 22. The pharmaceutical composition of embodiment 20, wherein the protease is selected from the group consisting of a metalloprotease, an endopeptidase, and an amino peptidase.

[0227] 23. The pharmaceutical composition of any one of embodiments 20-22, wherein the protease is selected from the group consisting of a trypsin, a trypsin-like protease, a chymotrypsin, an elastase, a pepsin, a mesotrypsin, a tryptase, and a chymase.

[0228] 24. The pharmaceutical composition of any one of embodiments 19-23, wherein the enzyme inhibitor is a protease inhibitor.

[0229] 25. The pharmaceutical composition of any one of embodiments 19-24, wherein the enzyme inhibitor is an intestinal enzyme inhibitor.

[0230] 26. The pharmaceutical composition of any one of embodiments 120-126, wherein the enzyme inhibitor is selected from the group consisting of sodium fluoride, ethylenediaminetetraacetic acid (EDTA), aprotinin, pepstatin, bestatin, bacitracin, boric acid, a soybean trypsin inhibitor (SBTI), a Bowman-Birk inhibitor (BBI), and a Kunitz trypsin inhibitor (KTI).

[0231] 27. The pharmaceutical composition of any one of embodiments 1 -26, wherein the non-naturally occurring melanocortin analog comprises a sequence of Formula (I), wherein:X1is absent, D-valine (dVal), or norleucine (Nle);X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of aspartic acid (Asp), Nle, D- norleucine (dNIe), hisitdine (His), D-histidine (dHis), D-phenylalanine (dPhe), arginine (Arg), D-arginine (dArg) and D-proline (dPro);-151 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOR2is selected from the group consisting of Asp, proline (Pro), lysine (Lys), cysteine (Cys), D-cysteine (dCys), D-penicillamine (dPen), penicillamine (Pen), glutamic acid (Glu), and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, dPro, tryptyl-proline (Trp-Pro), tryptyl-D-leucine (Trp-dLeu), trytpyl-D-valine (Trp-dVal), D-isoleucine (dlle), D- alanine (dAla), D-methionine (dMet), glycine (Gly), glycyl-glycine (Gly-Gly), beta-alanine (p-Ala), 3-aminomethyl-benzoic acid (Mamb), 1 -amino-1 -cyclopentane carboxylic (Cpe), 1 - amino-1 -cyclohexanecarboxylic acid (Che), 1 -aminocyclo-propane-1 -carboxylic acid (Acpc), prolyl-proline (Pro-Pro), prolyl-hisitdine (Pro-His), phenylalanyl-proline (Phe-Pro), D-histidyl-proline (dHis-Pro), hydroxyproline (Hyp), prolyl-glutamic acid (Pro-Glu), glutamic acid-histidine (Glu-His), Arg, dPhe, biphenylalanine (Bip), D-biphenylalanine (dBip), D- tyrosine (dTyr), D-tryptophan (dTrp), leucine (Leu), dLeu, dVal, D-glutamine (dGIn), tryptyl- arginine (Trp-Arg), histidyl-arginine (His-Arg), prolyl-arginine (Pro-Arg), arginyl-proline (Arg-Pro), and alanine (Ala);R4is selected from the group consisting of 2’-D-naphthylalanine (dNal(2’)), Bip, dBip, dPhe, para-fluoro-D-phenylalanine (p(F)dPhe), para-chloro-D-phenylalanine (p(CI)dPhe), para-iodo-D-phenylalanine (p(l)dPhe), and para-bromo-D-phenylalanine (p(Br)dPhe);R5is absent or selected from the group consisting of Arg, dArg, D-lysine (dLys), D- ornithine (dOrn), Glu, D-aspartic acid (dAsp), D-glutamic acid (dGlu), Pro, and His;R6is absent or is selected from the group consisting of Trp, tryptyl-glycine (Trp-Gly), tryptyl-proline (Trp-Pro), 2’-naphthylalanine (Nal(2’)), 1 ’-naphthylalanine (Nal(1 ’)), 1 ’-D- naphthylalanine (dNal(1 ’)), Phe, dPhe, and 1 ,2,3,4-tetrahydroisoquinoline carboxylic acid (Tic);R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, dOrn, and ornthine (Orn);Y1is selected from the group consisting of dVal, D-tert-leucine (dTle), dLys, Asp, D- threonine (dThr), p2-valine (p2Val), p3-valine (p3Val), Nle, Trp, dArg, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, p-proline (pPro), Nle, and valine (Vai);Y3is absent or selected from the group consisting of dVal, dThr, dPro, and Pro;-152-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOY4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R1or R2and R7when R1or R2is Asp or CO-cis- CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that the non-naturally occurring melanocortin analog does not comprise a sequence selected from the group consisting of:Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-Arg-NH2(SEQ ID NO: 6);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Asp-dPro-NH2(SEQ ID NO: 7);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dPro-NH2(SEQ ID NO: 3);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Asp-NH2(SEQ ID NO: 8);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 9);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Lys-dPro-dVal-NH2(SEQ ID NO: 10);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dLys-dPro-dVal-NH2(SEQ ID NO: 11 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Lys-dPro-NH2(SEQ ID NO: 12);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Lys-Val-Pro-NH2(SEQ ID NO: 13);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Lys-dVal-dPro-NH2(SEQ ID NO: 14);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dPro-dVal-NH2(SEQ ID NO: 15);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dVal-dPro-NH2(SEQ ID NO: 16);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 17);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dVal-NH2(SEQ ID NO: 18);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dTle-NH2(SEQ ID NO: 19);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dTle-dPro-NH2(SEQ ID NO: 20);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 21 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dPro-dTle-NH2(SEQ ID NO: 22);-153-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dTle-NH2(SEQ ID NO: 23);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 24);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-dVal-dPro-NH2(SEQ ID NO: 25);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Trp-NH2(SEQ ID NO: 26);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dTle-dPro-NH2(SEQ ID NO: 27);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dVal-NH2(SEQ ID NO: 28);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-NH2(SEQ ID NO: 29);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dLys-dPro-NH2(SEQ ID NO: 30);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dLys-dVal-dPro-NH2(SEQ ID NO: 31 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dVal-dPro-NH2(SEQ ID NO: 32);Ac-Nle-c[Asp-His-dNal(2')-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 33);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Asp-dVal-dPro-NH2(SEQ ID NO: 34);Ac-Nle-c[Asp-Pro-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 35);Ac-Nle-c[Asp-Pro-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 36);Ac-Nle-c[Asp-Pro-dNal(2')-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 37);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Nal(1 ’)-Lys]-dVal-dPro-NH2(SEQ ID NO: 38);Ac-Nle-c[Asp-Hyp-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 39);Ac-Nle-c[Asp-Hyp-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 40);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Phe-Lys]-dVal-dPro-NH2(SEQ ID NO: 41 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-dPhe-Lys]-dVal-dPro-NH2(SEQ ID NO: 42);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-dNal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 43);Ac-Nle-c[Asp-His-dNal(2')-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 44);Ac-dVal-dPro-c[Lys-Trp-Arg-dNal(2')-His-Asp]-Nle-Nle-NH2(SEQ ID NO: 45);Ac-dVal-dPro-c[Asp-Trp-Arg-dNal(2')-His-Lys]-Nle-Nle-NH2(SEQ ID NO: 46);Ac-Nle-c[Asp-His-dNal(2')-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 47);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Nal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 48);Ac-Arg-c[Glu-Pro-His-dNal(2')-His-Trp-Orn]-dVal-dPro-NH2(SEQ ID NO: 49);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dPro-NH2(SEQ ID NO: 3);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-dCys]-dArg-dPro-NH2(SEQ ID NO: 50);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 51 );Ac-His-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 52);-154-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-dHis-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 53);Ac-Nle-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 54);Ac-Nle-c[Asp-Pro-p(F)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 55);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 56);Ac-Nle-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 57);Ac-dArg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 58);Ac-Arg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 59);Ac-His-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 60);Ac-dHis-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 61 );Ac-Nle-c[Cys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 62);Ac-Nle-c[dCys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 63);Ac-Nle-c[dCys-His-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 64);Ac-dArg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 65);Ac-Arg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 66);Ac-His-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 67);Ac-dHis-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 68);Ac-Nle-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 69);Ac-Nle-c[Asp-His-p(F)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 70);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 71 );Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 72);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 73);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 74);Ac-Nle-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 75);Ac-dArg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 76);Ac-Arg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 77);Ac-His-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 78);Ac-dHis-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 79);Ac-Nle-c[Cys-Pro-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 80);Ac-Nle-c[dCys-Pro-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 81 );Ac-Nle-c[dCys-Pro-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 82);Ac-dArg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 83);-155-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Arg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 84);Ac-Nle-c[Asp-Bip-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 85);Ac-Nle-c[Asp-dGln-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 86);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 87);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Orn]-dVal-dPro-NH2(SEQ ID NO: 88);Ac-Nle-c[Asp-Trp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 89); c[CO-cis-CH=CH-CO-Pro-p(F)dPhe-Arg-Trp-l_ys]-dVal-dPro-NH2(SEQ ID NO: 90); c[CO-cis-CH=CH-CO-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 91 );Ac-Nle-c[Asp-[3-Ala-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 92);Ac-Nle-c[Pen-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 93);Ac-Nle-c[Asp-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 94);Ac-Nle-c[Asp-Mamb-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 95);Ac-Nle-c[Asp-His-p(F)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 96);Ac-Nle-c[Asp-Pro-p(F)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 97);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 98);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 99);Ac-dVal-dPro-c[Lys-Trp-Arg-p(F)dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 100);Ac-dVal-dPro-c[Asp-Trp-Arg-p(F)dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 101 );Ac-dVal-dPro-c[Lys-Trp-Arg-p(F)dPhe-His-Asp]-Nle-Nle-NH2(SEQ ID NO: 102);Ac-dVal-dPro-c[Asp-Trp-Arg-p(F)dPhe-His-Lys]-Nle-Nle-NH2(SEQ ID NO: 103);Ac-Nle-c[Asp-Pro-d(F);Phe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 104);Ac-Nle-c[Asp-Pro-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 105);Ac-dPhe-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 106);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 107);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 108);Ac-Nle-c[Pen-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 93);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 109);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 110);Ac-Nle-c[Cys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 111 );Ac-Nle-c[dCys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 112);Ac-Nle-c[dCys-His-p(CI)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 113);-156-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Arg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 114);Ac-His-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 115);Ac-dHis-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 1 16);Ac-Nle-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 117);Ac-Nle-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 118);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 1 19);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 120);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 121 );Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 122);Ac-Nle-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 123);Ac-dArg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 124);Ac-Arg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 125);Ac-His-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 126);Ac-dHis-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 127);Ac-Nle-c[Asp-dGln-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 128);Ac-Nle-c[Asp-dTrp-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 129);Ac-Nle-c[Asp-Bip-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 130);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Orn]-dVal-dPro-NH2(SEQ ID NO: 131 );Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-NH2(SEQ ID NO: 132); c[CO-cis-CH=CH-CO-Pro-p(CI)dPhe-Arg-Trp-l_ys]-dVal-dPro-NH2(SEQ ID NO: 133);Ac-Nle-c[Asp-Pro-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 134);Ac-Nle-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 118);Ac-Arg-c[Asp-Pro-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 135);Ac-Arg-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 136);Ac-Nle-c[Asp-Trp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 137); c[CO-cis-CH=CH-CO-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 138);Ac-Nle-c[Asp-[3-Ala-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 139);Ac-Nle-c[Pen-p(CI)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 140);Ac-Nle-c[Asp-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 141 );Ac-Nle-c[Asp-Mamb-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 142);Ac-Nle-c[Asp-His-p(CI)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 143);-157-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Pro-p(CI)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 144);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 145);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 146);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 147);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 148);Ac-dVal-dPro-c[Lys-Trp-Arg-p(CI)dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 149);Ac-dVal-dPro-c[Asp-Trp-Arg-p(CI)dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 150);Ac-dVal-dPro-c[Lys-Trp-Arg-p(CI)dPhe-His-Asp]-Nle-Nle-NH2(SEQ ID NO: 151 );Ac-dVal-dPro-c[Asp-Trp-Arg-p(CI)dPhe-His-Lys]-Nle-Nle-NH2(SEQ ID NO: 152);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 153);Ac-Nle-c[Asp-Pro-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 154);Ac-Nle-c[Cys-His-p(Br)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 155);Ac-dArg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 156);Ac-Arg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 157);Ac-His-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 158);Ac-dHis-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 159);Ac-Nle-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 160);Ac-Nle-c[Asp-His-p(Br)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 161 );Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 162);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 163);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 164);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 165);Ac-Nle-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 166);Ac-dArg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 167);Ac-Arg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 168);Ac-Nle-c[Asp-dBip-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 169);Ac-Nle-c[Asp-Pro-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 170);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 171 );Ac-Nle-c[Asp-His-Arg-p(l)dPhe-Arg-Tic-Lys]-dVal-dPro-NH2(SEQ ID NO: 172);Ac-Nle-c[Asp-Pro-Arg-p(l)dPhe-Arg-Tic-Lys]-dVal-dPro-NH2(SEQ ID NO: 173);Ac-Nle-c[Asp-Pro-p(l)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 174);-158-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-His-p(l)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 175);Ac-Nle-c[Asp-Pro-dBip-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 176);Ac-Nle-c[Lys-His-Arg-dBip-Arg-Tic-Asp]-dVal-dPro-NH2 (SEQ ID NO: 177);Ac-Nle-c[Lys-Pro-Arg-dBip-Arg-Tic-Asp]-dVal-dPro-NH2 (SEQ ID NO: 178);Ac-dArg-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 179);Ac-dNle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 180);Ac-dPro-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 181 );Ac-Nle-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 182);Ac-Nle-Nle-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 183);Ac-dVal-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 184);Ac-dNle-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 185);Ac-dArg-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2 (SEQ ID NO: 186);Ac-Arg-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 187);Ac-dHis-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 188);Ac-His-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 189);Ac-Asp-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 190);Ac-Arg-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 191 );Ac-His-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 192);Ac-dHis-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 193);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 194);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 195);Ac-dPhe-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 196);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dVal-dPro-NH2(SEQ ID NO: 197);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 198);Ac-Nle-c[Asp-Pro-dNal(2')-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 199);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Gly-Lys]-dVal-dPro-NH2(SEQ ID NO: 200);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 201 );Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 202);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 203);Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 204);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 205);-159-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 206);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 207);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 208);Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 209);Ac-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 210);Ac-Nle-c[Asp-Pro-dNal(2')-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 211 );Ac-Nle-c[Asp-Ala-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 212);Ac-Nle-c[Asp-Gly-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 213);Ac-Nle-c[Asp-Leu-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 214);Ac-dPhe-c[Asp-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 215); c[CO-cis-CH=CH-CO-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 216);Ac-Nle-c[dCys-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 217);Ac-Nle-c[Cys-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 218);Ac-Nle-c[Asp-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 219);Ac-Nle-c[Asp-Glu-His-dNal(2')-Arg-Trp-Gly-Lys]-dVal-dPro-NH2(SEQ ID NO: 220);Ac-Nle-c[Asp-Pro-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 221 );Ac-Nle-c[dPen-Pro-dPhe-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 222);Ac-Nle-c[dCys-Pro-dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 223);Ac-Nle-c[Asp-Pro-dPhe-Arg-Nal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 224);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dThr-dPro-dThr-OH (SEQ ID NO: 225);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 226);His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 227); dPhe-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 228); dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 229);Ac-Nle-c[Asp-Pro-dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 230);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 231 );Ac-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 232);Ac-dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 233);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dArg-dVal-dPro-NH2(SEQ ID NO: 234);Ac-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dLys-dPro-NH2(SEQ ID NO: 235);Ac-Nle-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 236);-160-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dArg-dPro-NH2 (SEQ ID NO: 237);Ac-dArg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 238);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 239);Ac-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 240);Ac-dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 241 );Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dArg-NH2 (SEQ ID NO: 242);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dVal-dPro-NH2 (SEQ ID NO: 243);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dLys-dVal-dPro-NH2 (SEQ ID NO: 244);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dArg-dVal-dPro-NH2 (SEQ ID NO: 245);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 246);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dTle-dPro-NH2 (SEQ ID NO: 247);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 248);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dTle-NH2(SEQ ID NO: 249);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dPro-NH2(SEQ ID NO: 250);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 251 );Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-dVal-dPro-NH2(SEQ ID NO: 252);Ac-dArg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 253);Ac-Nle-Nle-Nle-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 254);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Trp-NH2 (SEQ ID NO: 255);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Gly-Lys]-dVal-dPro-NH2(SEQ ID NO: 256);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dPro-dVal-NH2 (SEQ ID NO: 257);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dPro-NH2 (SEQ ID NO: 258);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 4);Ac-Nle-c[dCys-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 259);Ac-Nle-c[Asp-Pro-dPhe-Arg-Phe-Lys]-dVal-dPro-NH2(SEQ ID NO: 261 );Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 262); c[CO-cis-CH=CH-CO-Pro-dPhe-Arg-Trp-l_ys]-dVal-dPro-NH2(SEQ ID NO: 263);Ac-Asp-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 264);Ac-dVal-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 265);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 266);Ac-Nle-c[Asp-Pro-dPhe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 267);-161 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-dPhe-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 268);Ac-Nle-c[Asp-dTyr-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 269);Ac-Nle-c[Asp-dGln-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 270);Ac-Nle-c[Asp-dTrp-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 271 );Ac-Nle-c[Asp-Bip-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 272);Ac-Nle-c[Asp-Leu-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 273);Ac-dHis-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 274);Ac-His-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 275);Ac-Nle-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 276);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dArg-dVal-dPro-NH2(SEQ ID NO: 277);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dLys-dVal-dPro-NH2(SEQ ID NO: 278);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dArg-dPro-NH2(SEQ ID NO: 279);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dLys-dPro-NH2(SEQ ID NO: 280);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 281 );Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 282);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 283);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 284);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 285);Ac-Nle-c[dPen-dPhe-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 286);Ac-Nle-c[Asp-Hyp-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 287);Ac-Nle-c[Asp-Pro-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 288);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 289);Ac-Nle-c[Cys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 290);Ac-Nle-c[dCys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 291 );Ac-Arg-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 292);Ac-dArg-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 293);Ac-Asp-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 294);Ac-His-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 295);Ac-Nle-c[Asp-Gly-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 296);Ac-Nle-c[Asp-dLeu-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 297);Ac-Nle-c[Asp-dMet-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 298);-162-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO c[CO-cis-CH=CH-CO-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 299);Ac-Nle-c[Asp-p-Ala-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 300);Ac-Nle-c[Asp-Mamb-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 301 );Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dArg-NH2 (SEQ ID NO: 302);Ac-dVal-dPro-c[Lys-Trp-Arg-dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 303);Ac-dVal-dPro-c[Asp-Trp-Arg-dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 304);Ac-dVal-dPro-c[Lys-Trp-Arg-dPhe-His-Asp]-Nle-Nle-NH2(SEQ ID NO: 305);Ac-dVal-dPro-c[Asp-Trp-Arg-dPhe-His-Lys]-Nle-Nle-NH2(SEQ ID NO: 306);Ac-Arg-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 307);Ac-Nle-c[Asp-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 308);Ac-Arg-c[Asp-Pro...

Claims

1. Docket No.: 183B-412994-WOCLAIMS l / We claim:

1. An orally deliverable pharmaceutical composition comprising a non-naturally occurring melanocortin analog, the non-naturally occurring melanocortin analog comprising a sequence of Formula (I):X1-X2-X3- R1- R2- R3- R4- R5- R6- R7- Y1- Y2-Y3- Y4( I ) , wherein:X1is absent, D-valine (dVal), or norleucine (Nle);X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of aspartic acid (Asp), Nle, D- norleucine (dNIe), hisitdine (His), D-histidine (dHis), D-phenylalanine (dPhe), arginine (Arg), D-arginine (dArg) and D-proline (dPro);R2is selected from the group consisting of Asp, proline (Pro), lysine (Lys), cysteine (Cys), D-cysteine (dCys), D-penicillamine (dPen), penicillamine (Pen), glutamic acid (Glu), and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, dPro, tryptyl-proline (Trp-Pro), tryptyl-D-leucine (Trp-dLeu), trytpyl-D-valine (Trp-dVal), D-isoleucine (dlle), D- alanine (dAla), D-methionine (dMet), glycine (Gly), glycyl-glycine (Gly-Gly), beta-alanine (p-Ala), 3-aminomethyl-benzoic acid (Mamb), 1 -amino-1 -cyclopentane carboxylic (Cpe), 1 - amino-1 -cyclohexanecarboxylic acid (Che), 1 -aminocyclo-propane-1 -carboxylic acid (Acpc), prolyl-proline (Pro-Pro), prolyl-hisitdine (Pro-His), phenylalanyl-proline (Phe-Pro), D-histidyl-proline (dHis-Pro), hydroxyproline (Hyp), prolyl-glutamic acid (Pro-Glu), glutamic acid-histidine (Glu-His), Arg, dPhe, biphenylalanine (Bip), D-biphenylalanine (dBip), D- tyrosine (dTyr), D-tryptophan (dTrp), leucine (Leu), dLeu, dVal, D-glutamine (dGIn), tryptyl- arginine (Trp-Arg), histidyl-arginine (His-Arg), prolyl-arginine (Pro-Arg), arginyl-proline (Arg-Pro), and alanine (Ala);R4is selected from the group consisting of 2’-D-naphthylalanine (dNal(2’)), Bip, dBip, dPhe, para-fluoro-D-phenylalanine (p(F)dPhe), para-chloro-D-phenylalanine-208-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO(p(CI)dPhe), para-iodo-D-phenylalanine (p(l)dPhe), and para-bromo-D-phenylalanine (p(Br)dPhe);R5is absent or selected from the group consisting of Arg, dArg, D-lysine (dLys), D- ornithine (dOrn), Glu, D-aspartic acid (dAsp), D-glutamic acid (dGlu), Pro, and His;R6is absent or is selected from the group consisting of Trp, tryptyl-glycine (Trp-Gly), tryptyl-proline (Trp-Pro), 2’-naphthylalanine (Nal(2’)), 1 ’-naphthylalanine (Nal(1 ’)), 1 ’-D- naphthylalanine (dNal(1 ’)), Phe, dPhe, and 1 ,2,3,4-tetrahydroisoquinoline carboxylic acid (Tic);R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, dOrn, and ornthine (Orn);Y1is selected from the group consisting of dVal, D-tert-leucine (dTle), dLys, Asp, D- threonine (dThr), p2-valine (p2Val), p3-valine (p3Val), Nle, Trp, dArg, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, p-proline (pPro), Nle, and valine (Vai);Y3is absent or selected from the group consisting of dVal, dThr, dPro, and Pro;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R1or R2and R7when R1or R2is Asp or CO-cis- CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that: when R4is dNal(2’), then R3is not Pro-His, Hyp, or Pro-Pro, R5is not His, R6is not Phe, dPhe, Nal(1 ’), or dNal(1 ’), and either (i) Y1is dVal, Y2is dPro, and Y3-Y4are absent (ii) Y1is dLys or dArg, and R2is dPen, or (iii) Y1is Nle,-209-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO when R4is p(F)dPhe, then R3is dPhe, dBip, dTyr, dTrp, or Pro, wherein when R3is Pro then either (i) R6is not Trp or (ii) Y1and Y2are each independently dVal or dTle, when R4is p(CI)dPhe, then R3is dPhe, dBip, dTyr, or His, wherein when R3is His then R1is dArg and Y1is dVal, when R4is p(Br)dPhe, then R3is dPhe, Bip, dTyr, dTrp, dGIn, or His, wherein when R3is His then either (i) R1is His or dHis and Y1is dTle or (ii) R2is dCys, when R4is p(l)dPhe, then R3is Arg-Pro, when R4is dBip, then R2is Asp and R3is not Pro, when R4is dNal(2’) and R3is Pro, then R1is absent, dPhe, or Nle and R6is Trp, wherein when R1is absent, then R2is CO-cis-CH=CH-CO, when R1is dPhe, then R2is dPen, and when R1is Nle, then (i) R2is Asp and either (a) R5is not Arg, Pro, or absent, (b) R7is not Lys, or (c) X1-X3are all Nle, (ii) R2and R7are each is dPen or (iii) R2is Pen or Cys, and R7is dCys, when R4is dNal(2’) and R3is Ala, Leu, Gly, or His, then either R2is dPen or R6is Trp-Pro, when R4is dNal(2’) and R3is Glu-His, then R6is Trp, when R4is dNal(2’) and R3is absent, then (i) R2is not Asp, (ii) R2and R7are not both Cys, and (iii) when R2is dCys, then R7is not Pen, when R4is dPhe and R3is Pro, then the N-terminus is acetylated, X1-X2are each independently absent or Nle, X3is absent, R1is dNIe, dPhe or Nle, R2is Cys or Asp, R5is Arg or Pro, R6is Trp or dNal(T), the C-terminus is amidated, wherein when R1is Nle, then either (i) Y1is dVal, Y2is dPro and at least one of X1-X2is Nle, (ii) Y1is dVal or Lys and Y2is dArg or Vai, or (iii) Y1is dLys, Asp, dThr, p2Val, or p3Val, and Y2is not dVal, and when R4is dPhe, and R3is not Pro, then the N-terminus is acetylated, X1-X3are absent, R1is absent, Nle, Arg, or dArg, Y1is dVal, Y2is dPro and Y3-Y4are absent, ad (i) R3is absent and R2or R7is Cys, (ii) R3is Trp-Pro and either (a) R5is His, (b) R6is Nal(1 ’), dNal(1 ’), Phe, or dPhe, or (c) R7is dCys, (iii) R3is Pro-His, R1is Nle and R5is His, (iv) R3is Hyp or dAla and either R1is not Nle or R6is not Trp, (v) R3is His and R5is Pro, or (vi) R3is selected from dBip, Pro-Pro, Arg, dVal, Cpe, Che, Phe-Pro, dHis-Pro, dlle, Trp-Leu, and Trp-dVal.-210-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO2. A pharmaceutical composition comprising a non-naturally occurring melanocortin receptor analog and a permeation enhancer, the non-naturally occurring melanocortin receptor analog comprising a sequence of Formula (I):X1-X2-X3- R1- R2- R3- R4- R5- R6- R7- Y1- Y2-Y3- Y4( I ) , wherein:X1is absent, D-valine (dVal), or norleucine (Nle);X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of aspartic acid (Asp), Nle, D- norleucine (dNIe), hisitdine (His), D-histidine (dHis), D-phenylalanine (dPhe), arginine (Arg), D-arginine (dArg) and D-proline (dPro);R2is selected from the group consisting of Asp, proline (Pro), lysine (Lys), cysteine (Cys), D-cysteine (dCys), D-penicillamine (dPen), penicillamine (Pen), glutamic acid (Glu), and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, dPro, tryptyl-proline (Trp-Pro), tryptyl-D-leucine (Trp-dLeu), trytpyl-D-valine (Trp-dVal), D-isoleucine (dlle), D- alanine (dAla), D-methionine (dMet), glycine (Gly), glycyl-glycine (Gly-Gly), beta-alanine (p-Ala), 3-aminomethyl-benzoic acid (Mamb), 1 -amino-1 -cyclopentane carboxylic (Cpe), 1 - amino-1 -cyclohexanecarboxylic acid (Che), 1 -aminocyclo-propane-1 -carboxylic acid (Acpc), prolyl-proline (Pro-Pro), prolyl-hisitdine (Pro-His), phenylalanyl-proline (Phe-Pro), D-histidyl-proline (dHis-Pro), hydroxyproline (Hyp), prolyl-glutamic acid (Pro-Glu), glutamic acid-histidine (Glu-His), Arg, dPhe, biphenylalanine (Bip), D-biphenylalanine (dBip), D- tyrosine (dTyr), D-tryptophan (dTrp), leucine (Leu), dLeu, dVal, D-glutamine (dGIn), tryptyl- arginine (Trp-Arg), histidyl-arginine (His-Arg), prolyl-arginine (Pro-Arg), arginyl-proline (Arg-Pro), and alanine (Ala);R4is selected from the group consisting of 2’-D-naphthylalanine (dNal(2’)), Bip, dBip, dPhe, para-fluoro-D-phenylalanine (p(F)dPhe), para-chloro-D-phenylalanine (p(CI)dPhe), para-iodo-D-phenylalanine (p(l)dPhe), and para-bromo-D-phenylalanine (p(Br)dPhe);R5is absent or selected from the group consisting of Arg, dArg, D-lysine (dLys), D- ornithine (dOrn), Glu, D-aspartic acid (dAsp), D-glutamic acid (dGlu), Pro, and His;-211 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOR6is absent or is selected from the group consisting of Trp, tryptyl-glycine (Trp-Gly), tryptyl-proline (Trp-Pro), 2’-naphthylalanine (Nal(2’)), 1 ’-naphthylalanine (Nal(1 ’)), 1 ’-D- naphthylalanine (dNal(1 ’)), Phe, dPhe, and 1 ,2,3,4-tetrahydroisoquinoline carboxylic acid (Tic);R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, dOrn, and ornthine (Orn);Y1is selected from the group consisting of dVal, D-tert-leucine (dTle), dLys, Asp, D- threonine (dThr), p2-valine (p2Val), p3-valine (p3Val), Nle, Trp, dArg, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, p-proline (pPro), Nle, and valine (Vai);Y3is absent or selected from the group consisting of dVal, dThr, dPro, and Pro;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R1or R2and R7when R1or R2is Asp or CO-cis- CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that: when R4is dNal(2’), then R3is not Pro-His, Hyp, or Pro-Pro, R5is not His, R6is not Phe, dPhe, Nal(1 ’), or dNal(1 ’), and either (i) Y1is dVal, Y2is dPro, and Y3-Y4are absent (ii) Y1is dLys or dArg, and R2is dPen, or (iii) Y1is Nle, when R4is p(F)dPhe, then R3is dPhe, dBip, dTyr, dTrp, or Pro, wherein when R3is Pro then either (i) R6is not Trp or (ii) Y1and Y2are each independently dVal or dTle, when R4is p(CI)dPhe, then R3is dPhe, dBip, dTyr, or His, wherein when R3is His then R1is dArg and Y1is dVal,-212-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO when R4is p(Br)dPhe, then R3is dPhe, Bip, dTyr, dTrp, dGIn, or His, wherein when R3is His then either (i) R1is His or dHis and Y1is dTle or (ii) R2is dCys, when R4is p(l)dPhe, then R3is Arg-Pro, when R4is dBip, then R2is Asp and R3is not Pro, when R4is dNal(2’) and R3is Pro, then R1is absent, dPhe, or Nle and R6is Trp, wherein when R1is absent, then R2is CO-cis-CH=CH-CO, when R1is dPhe, then R2is dPen, and when R1is Nle, then (i) R2is Asp and either (a) R5is not Arg, Pro, or absent, (b) R7is not Lys, or (c) X1-X3are all Nle, (ii) R2and R7are each is dPen or (iii) R2is Pen or Cys, and R7is dCys, when R4is dNal(2’) and R3is Ala, Leu, Gly, or His, then either R2is dPen or R6is Trp-Pro, when R4is dNal(2’) and R3is Glu-His, then R6is Trp, when R4is dNal(2’) and R3is absent, then (i) R2is not Asp, (ii) R2and R7are not both Cys, and (iii) when R2is dCys, then R7is not Pen, when R4is dPhe and R3is Pro, then the N-terminus is acetylated, X1-X2are each independently absent or Nle, X3is absent, R1is dNIe, dPhe or Nle, R2is Cys or Asp, R5is Arg or Pro, R6is Trp or dNal(T), the C-terminus is amidated, wherein when R1is Nle, then either (i) Y1is dVal, Y2is dPro and at least one of X1-X2is Nle, (ii) Y1is dVal or Lys and Y2is dArg or Vai, or (iii) Y1is dLys, Asp, dThr, p2Val, or p3Val, and Y2is not dVal, and when R4is dPhe, and R3is not Pro, then the N-terminus is acetylated, X1-X3are absent, R1is absent, Nle, Arg, or dArg, Y1is dVal, Y2is dPro and Y3-Y4are absent, ad (i) R3is absent and R2or R7is Cys, (ii) R3is Trp-Pro and either (a) R5is His, (b) R6is Nal(1 ’), dNal(1 ’), Phe, or dPhe, or (c) R7is dCys, (iii) R3is Pro-His, R1is Nle and R5is His, (iv) R3is Hyp or dAla and either R1is not Nle or R6is not Trp, (v) R3is His and R5is Pro, or (vi) R3is selected from dBip, Pro-Pro, Arg, dVal, Cpe, Che, Phe-Pro, dHis-Pro, dlle, Trp-Leu, and Trp-dVal.

3. A pharmaceutical composition for oral administration of a non-naturally occurring melanocortin receptor analog, the composition comprising a permeation enhancer and a non-naturally occurring melanocortin receptor analog comprising a sequence of Formula (I):-213-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOX1-X2-X3- R1- R2- R3- R4- R5- R6- R7- Y1- Y2-Y3- Y4( I ) , wherein:X1is absent, D-valine (dVal), or norleucine (Nle);X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of aspartic acid (Asp), Nle, D- norleucine (dNIe), hisitdine (His), D-histidine (dHis), D-phenylalanine (dPhe), arginine (Arg), D-arginine (dArg) and D-proline (dPro);R2is selected from the group consisting of Asp, proline (Pro), lysine (Lys), cysteine (Cys), D-cysteine (dCys), D-penicillamine (dPen), penicillamine (Pen), glutamic acid (Glu), and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, dPro, tryptyl-proline (Trp-Pro), tryptyl-D-leucine (Trp-dLeu), trytpyl-D-valine (Trp-dVal), D-isoleucine (dlle), D- alanine (dAla), D-methionine (dMet), glycine (Gly), glycyl-glycine (Gly-Gly), beta-alanine (p-Ala), 3-aminomethyl-benzoic acid (Mamb), 1 -amino-1 -cyclopentane carboxylic (Cpe), 1 - amino-1 -cyclohexanecarboxylic acid (Che), 1 -aminocyclo-propane-1 -carboxylic acid (Acpc), prolyl-proline (Pro-Pro), prolyl-hisitdine (Pro-His), phenylalanyl-proline (Phe-Pro), D-histidyl-proline (dHis-Pro), hydroxyproline (Hyp), prolyl-glutamic acid (Pro-Glu), glutamic acid-histidine (Glu-His), Arg, dPhe, biphenylalanine (Bip), D-biphenylalanine (dBip), D- tyrosine (dTyr), D-tryptophan (dTrp), leucine (Leu), dLeu, dVal, D-glutamine (dGIn), tryptyl- arginine (Trp-Arg), histidyl-arginine (His-Arg), prolyl-arginine (Pro-Arg), arginyl-proline (Arg-Pro), and alanine (Ala);R4is selected from the group consisting of 2’-D-naphthylalanine (dNal(2’)), Bip, dBip, dPhe, para-fluoro-D-phenylalanine (p(F)dPhe), para-chloro-D-phenylalanine (p(CI)dPhe), para-iodo-D-phenylalanine (p(l)dPhe), and para-bromo-D-phenylalanine (p(Br)dPhe);R5is absent or selected from the group consisting of Arg, dArg, D-lysine (dLys), D- ornithine (dOrn), Glu, D-aspartic acid (dAsp), D-glutamic acid (dGlu), Pro, and His;R6is absent or is selected from the group consisting of Trp, tryptyl-glycine (Trp-Gly), tryptyl-proline (Trp-Pro), 2’-naphthylalanine (Nal(2’)), 1 ’-naphthylalanine (Nal(1 ’)), 1 ’-D--214-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO naphthylalanine (dNal(1 ’)), Phe, dPhe, and 1 ,2,3,4-tetrahydroisoquinoline carboxylic acid (Tic);R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, dOrn, and ornthine (Orn);Y1is selected from the group consisting of dVal, D-tert-leucine (dTle), dLys, Asp, D- threonine (dThr), p2-valine (p2Val), p3-valine (p3Val), Nle, Trp, dArg, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, p-proline (pPro), Nle, and valine (Vai);Y3is absent or selected from the group consisting of dVal, dThr, dPro, and Pro;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R1or R2and R7when R1or R2is Asp or CO-cis- CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that: when R4is dNal(2’), then R3is not Pro-His, Hyp, or Pro-Pro, R5is not His, R6is not Phe, dPhe, Nal(1 ’), or dNal(1 ’), and either (i) Y1is dVal, Y2is dPro, and Y3-Y4are absent (ii) Y1is dLys or dArg, and R2is dPen, or (iii) Y1is Nle, when R4is p(F)dPhe, then R3is dPhe, dBip, dTyr, dTrp, or Pro, wherein when R3is Pro then either (i) R6is not Trp or (ii) Y1and Y2are each independently dVal or dTle, when R4is p(CI)dPhe, then R3is dPhe, dBip, dTyr, or His, wherein when R3is His then R1is dArg and Y1is dVal, when R4is p(Br)dPhe, then R3is dPhe, Bip, dTyr, dTrp, dGIn, or His, wherein when R3is His then either (i) R1is His or dHis and Y1is dTle or (ii) R2is dCys, when R4is p(l)dPhe, then R3is Arg-Pro,-215-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO when R4is dBip, then R2is Asp and R3is not Pro, when R4is dNal(2’) and R3is Pro, then R1is absent, dPhe, or Nle and R6is Trp, wherein when R1is absent, then R2is CO-cis-CH=CH-CO, when R1is dPhe, then R2is dPen, and when R1is Nle, then (i) R2is Asp and either (a) R5is not Arg, Pro, or absent, (b) R7is not Lys, or (c) X1-X3are all Nle, (ii) R2and R7are each is dPen or (iii) R2is Pen or Cys, and R7is dCys, when R4is dNal(2’) and R3is Ala, Leu, Gly, or His, then either R2is dPen or R6is Trp-Pro, when R4is dNal(2’) and R3is Glu-His, then R6is Trp, when R4is dNal(2’) and R3is absent, then (i) R2is not Asp, (ii) R2and R7are not both Cys, and (iii) when R2is dCys, then R7is not Pen, when R4is dPhe and R3is Pro, then the N-terminus is acetylated, X1-X2are each independently absent or Nle, X3is absent, R1is dNIe, dPhe or Nle, R2is Cys or Asp, R5is Arg or Pro, R6is Trp or dNal(T), the C-terminus is amidated, wherein when R1is Nle, then either (i) Y1is dVal, Y2is dPro and at least one of X1-X2is Nle, (ii) Y1is dVal or Lys and Y2is dArg or Vai, or (iii) Y1is dLys, Asp, dThr, p2Val, or p3Val, and Y2is not dVal, and when R4is dPhe, and R3is not Pro, then the N-terminus is acetylated, X1-X3are absent, R1is absent, Nle, Arg, or dArg, Y1is dVal, Y2is dPro and Y3-Y4are absent, ad (i) R3is absent and R2or R7is Cys, (ii) R3is Trp-Pro and either (a) R5is His, (b) R6is Nal(1 ’), dNal(1 ’), Phe, or dPhe, or (c) R7is dCys, (iii) R3is Pro-His, R1is Nle and R5is His, (iv) R3is Hyp or dAla and either R1is not Nle or R6is not Trp, (v) R3is His and R5is Pro, or (vi) R3is selected from dBip, Pro-Pro, Arg, dVal, Cpe, Che, Phe-Pro, dHis-Pro, dlle, Trp-Leu, and Trp-dVal.

4. A pharmaceutical composition formulated to deliver about 0.1 mg / kg to about 5 mg / kg, per body weight of a subject, of a non-naturally occurring melanocortin receptor analog to the subject, the pharmaceutical composition comprising: a permeation enhancer; and a non-naturally occurring melanocortin receptor analog comprising a sequence of Formula (I):X1-X2-X3- R1- R2- R3- R4- R5- R6- R7- Y1- Y2-Y3- Y4( I ) ,-216-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO wherein:X1is absent, D-valine (dVal), or norleucine (Nle);X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of aspartic acid (Asp), Nle, D- norleucine (dNIe), hisitdine (His), D-histidine (dHis), D-phenylalanine (dPhe), arginine (Arg), D-arginine (dArg) and D-proline (dPro);R2is selected from the group consisting of Asp, proline (Pro), lysine (Lys), cysteine (Cys), D-cysteine (dCys), D-penicillamine (dPen), penicillamine (Pen), glutamic acid (Glu), and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, dPro, tryptyl-proline (Trp-Pro), tryptyl-D-leucine (Trp-dLeu), trytpyl-D-valine (Trp-dVal), D-isoleucine (dlle), D- alanine (dAla), D-methionine (dMet), glycine (Gly), glycyl-glycine (Gly-Gly), beta-alanine (p-Ala), 3-aminomethyl-benzoic acid (Mamb), 1 -amino-1 -cyclopentane carboxylic (Cpe), 1 - amino-1 -cyclohexanecarboxylic acid (Che), 1 -aminocyclo-propane-1 -carboxylic acid (Acpc), prolyl-proline (Pro-Pro), prolyl-hisitdine (Pro-His), phenylalanyl-proline (Phe-Pro), D-histidyl-proline (dHis-Pro), hydroxyproline (Hyp), prolyl-glutamic acid (Pro-Glu), glutamic acid-histidine (Glu-His), Arg, dPhe, biphenylalanine (Bip), D-biphenylalanine (dBip), D- tyrosine (dTyr), D-tryptophan (dTrp), leucine (Leu), dLeu, dVal, D-glutamine (dGIn), tryptyl- arginine (Trp-Arg), histidyl-arginine (His-Arg), prolyl-arginine (Pro-Arg), arginyl-proline (Arg-Pro), and alanine (Ala);R4is selected from the group consisting of 2’-D-naphthylalanine (dNal(2’)), Bip, dBip, dPhe, para-fluoro-D-phenylalanine (p(F)dPhe), para-chloro-D-phenylalanine (p(CI)dPhe), para-iodo-D-phenylalanine (p(l)dPhe), and para-bromo-D-phenylalanine (p(Br)dPhe);R5is absent or selected from the group consisting of Arg, dArg, D-lysine (dLys), D- ornithine (dOrn), Glu, D-aspartic acid (dAsp), D-glutamic acid (dGlu), Pro, and His;R6is absent or is selected from the group consisting of Trp, tryptyl-glycine (Trp-Gly), tryptyl-proline (Trp-Pro), 2’-naphthylalanine (Nal(2’)), 1 ’-naphthylalanine (Nal(1 ’)), 1 ’-D- naphthylalanine (dNal(1 ’)), Phe, dPhe, and 1 ,2,3,4-tetrahydroisoquinoline carboxylic acid (Tic);-217-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOR7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, dOrn, and ornthine (Orn);Y1is selected from the group consisting of dVal, D-tert-leucine (dTle), dLys, Asp, D- threonine (dThr), p2-valine (p2Val), p3-valine (p3Val), Nle, Trp, dArg, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, p-proline (pPro), Nle, and valine (Vai);Y3is absent or selected from the group consisting of dVal, dThr, dPro, and Pro;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R1or R2and R7when R1or R2is Asp or CO-cis- CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that: when R4is dNal(2’), then R3is not Pro-His, Hyp, or Pro-Pro, R5is not His, R6is not Phe, dPhe, Nal(1 ’), or dNal(1 ’), and either (i) Y1is dVal, Y2is dPro, and Y3-Y4are absent (ii) Y1is dLys or dArg, and R2is dPen, or (iii) Y1is Nle, when R4is p(F)dPhe, then R3is dPhe, dBip, dTyr, dTrp, or Pro, wherein when R3is Pro then either (i) R6is not Trp or (ii) Y1and Y2are each independently dVal or dTle, when R4is p(CI)dPhe, then R3is dPhe, dBip, dTyr, or His, wherein when R3is His then R1is dArg and Y1is dVal, when R4is p(Br)dPhe, then R3is dPhe, Bip, dTyr, dTrp, dGIn, or His, wherein when R3is His then either (i) R1is His or dHis and Y1is dTle or (ii) R2is dCys, when R4is p(l)dPhe, then R3is Arg-Pro, when R4is dBip, then R2is Asp and R3is not Pro,-218-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO when R4is dNal(2’) and R3is Pro, then R1is absent, dPhe, or Nle and R6is Trp, wherein when R1is absent, then R2is CO-cis-CH=CH-CO, when R1is dPhe, then R2is dPen, and when R1is Nle, then (i) R2is Asp and either (a) R5is not Arg, Pro, or absent, (b) R7is not Lys, or (c) X1-X3are all Nle, (ii) R2and R7are each is dPen or (iii) R2is Pen or Cys, and R7is dCys, when R4is dNal(2’) and R3is Ala, Leu, Gly, or His, then either R2is dPen or R6is Trp-Pro, when R4is dNal(2’) and R3is Glu-His, then R6is Trp, when R4is dNal(2’) and R3is absent, then (i) R2is not Asp, (ii) R2and R7are not both Cys, and (iii) when R2is dCys, then R7is not Pen, when R4is dPhe and R3is Pro, then the N-terminus is acetylated, X1-X2are each independently absent or Nle, X3is absent, R1is dNIe, dPhe or Nle, R2is Cys or Asp, R5is Arg or Pro, R6is Trp or dNal(T), the C-terminus is amidated, wherein when R1is Nle, then either (i) Y1is dVal, Y2is dPro and at least one of X1-X2is Nle, (ii) Y1is dVal or Lys and Y2is dArg or Vai, or (iii) Y1is dLys, Asp, dThr, p2Val, or p3Val, and Y2is not dVal, and when R4is dPhe, and R3is not Pro, then the N-terminus is acetylated, X1-X3are absent, R1is absent, Nle, Arg, or dArg, Y1is dVal, Y2is dPro and Y3-Y4are absent, ad (i) R3is absent and R2or R7is Cys, (ii) R3is Trp-Pro and either (a) R5is His, (b) R6is Nal(1 ’), dNal(1 ’), Phe, or dPhe, or (c) R7is dCys, (iii) R3is Pro-His, R1is Nle and R5is His, (iv) R3is Hyp or dAla and either R1is not Nle or R6is not Trp, (v) R3is His and R5is Pro, or (vi) R3is selected from dBip, Pro-Pro, Arg, dVal, Cpe, Che, Phe-Pro, dHis-Pro, dlle, Trp-Leu, and Trp-dVal.

5. The pharmaceutical composition of any one of claims 1 -4, wherein the non- naturally occurring melanocortin receptor analog is present at a concentration of about 0.01 mg / mL to about 200 mg / mL.

6. The pharmaceutical composition of any one of claims 1 -5, wherein the non- naturally occurring melanocortin receptor analog is present at a concentration of about 0.1 mg / mL to about 100 mg / mL.-219-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO7. The pharmaceutical composition of any one of claims 1 -6, wherein the non- naturally occurring melanocortin receptor analog is present at a concentration of about 0.1 mg / mL to about 5 mg / mL.

8. The pharmaceutical composition of any one of claims 1 -7, wherein the non- naturally occurring melanocortin receptor analog is present in an amount of about 1 .0 mg to about 20 g.

9. The pharmaceutical composition of any one of claims 1 -8, wherein the non- naturally occurring melanocortin receptor analog is present in an amount of about 10 mg to about 1500 mg.

10. The pharmaceutical composition of any one of claims 1 -9, wherein the permeation enhancer is present at a concentration of about 0.1 mg / mL to about 25 mg / mL.

11. The pharmaceutical composition of any one of claims 1 -10, wherein the permeation enhancer is present at a concentration of about 6 mg / mL.

12. The pharmaceutical composition of any one of claims 1 -1 1 , wherein the permeation enhancer is present in an amount of about 10 mg to about 3000 mg.

13. The pharmaceutical composition of any one of claims 1 -12, further comprising water.

14. The pharmaceutical composition of any one of claims 1 -13, formulated for oral delivery.

15. The pharmaceutical composition of claim 14, formulated as an oral dosage unit.-220-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO16. The pharmaceutical composition of claim 15, wherein the oral dosage unit is a tablet or a capsule.

17. The pharmaceutical composition of claim 16, wherein the capsule is a liquid- filled capsule or a semi-solid-filled capsule.

18. The pharmaceutical composition of any one of claims 1 -17, further comprising an excipient.

19. The pharmaceutical composition of claim 18, wherein the excipient comprises or consists of an enzyme inhibitor.

20. The pharmaceutical composition of claim 18 or 19, wherein the excipient may comprise one or more compounds which inhibit, bind, or otherwise target an enzyme comprising a phosphatase or a protease.

21. The pharmaceutical composition of claim 20, wherein the phosphatase is an intestinal phosphatase.

22. The pharmaceutical composition of claim 20, wherein the protease is selected from the group consisting of a metalloprotease, an endopeptidase, and an amino peptidase.

23. The pharmaceutical composition of claim 20 or 22, wherein the protease is selected from the group consisting of a trypsin, a trypsin-like protease, a chymotrypsin, an elastase, a pepsin, a mesotrypsin, a tryptase, and a chymase.

24. The pharmaceutical composition of any one of claims 19-23, wherein the enzyme inhibitor is a protease inhibitor.-221 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO25. The pharmaceutical composition of any one of claims 19-24, wherein the enzyme inhibitor is an intestinal enzyme inhibitor.

26. The pharmaceutical composition of any one of claims 19-25, wherein the enzyme inhibitor is selected from the group consisting of sodium fluoride, ethylenediaminetetraacetic acid (EDTA), aprotinin, pepstatin, bestatin, bacitracin, boric acid, a soybean trypsin inhibitor (SBTI), a Bowman-Birk inhibitor (BBI), and a Kunitz trypsin inhibitor (KTI).

27. The pharmaceutical composition of any one of claims 1 -26, wherein the non- naturally occurring melanocortin analog comprises a sequence of Formula (I), wherein:X1is absent, D-valine (dVal), or norleucine (Nle);X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of aspartic acid (Asp), Nle, D- norleucine (dNIe), hisitdine (His), D-histidine (dHis), D-phenylalanine (dPhe), arginine (Arg), D-arginine (dArg) and D-proline (dPro);R2is selected from the group consisting of Asp, proline (Pro), lysine (Lys), cysteine (Cys), D-cysteine (dCys), D-penicillamine (dPen), penicillamine (Pen), glutamic acid (Glu), and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, dPro, tryptyl-proline (Trp-Pro), tryptyl-D-leucine (Trp-dLeu), trytpyl-D-valine (Trp-dVal), D-isoleucine (dlle), D- alanine (dAla), D-methionine (dMet), glycine (Gly), glycyl-glycine (Gly-Gly), beta-alanine (p-Ala), 3-aminomethyl-benzoic acid (Mamb), 1 -amino-1 -cyclopentane carboxylic (Cpe), 1 - amino-1 -cyclohexanecarboxylic acid (Che), 1 -aminocyclo-propane-1 -carboxylic acid (Acpc), prolyl-proline (Pro-Pro), prolyl-hisitdine (Pro-His), phenylalanyl-proline (Phe-Pro), D-histidyl-proline (dHis-Pro), hydroxyproline (Hyp), prolyl-glutamic acid (Pro-Glu), glutamic acid-histidine (Glu-His), Arg, dPhe, biphenylalanine (Bip), D-biphenylalanine (dBip), D- tyrosine (dTyr), D-tryptophan (dTrp), leucine (Leu), dLeu, dVal, D-glutamine (dGIn), tryptyl--222-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO arginine (Trp-Arg), histidyl-arginine (His-Arg), prolyl-arginine (Pro-Arg), arginyl-proline (Arg-Pro), and alanine (Ala);R4is selected from the group consisting of 2’-D-naphthylalanine (dNal(2’)), Bip, dBip, dPhe, para-fluoro-D-phenylalanine (p(F)dPhe), para-chloro-D-phenylalanine (p(CI)dPhe), para-iodo-D-phenylalanine (p(l)dPhe), and para-bromo-D-phenylalanine (p(Br)dPhe);R5is absent or selected from the group consisting of Arg, dArg, D-lysine (dLys), D- ornithine (dOrn), Glu, D-aspartic acid (dAsp), D-glutamic acid (dGlu), Pro, and His;R6is absent or is selected from the group consisting of Trp, tryptyl-glycine (Trp-Gly), tryptyl-proline (Trp-Pro), 2’-naphthylalanine (Nal(2’)), 1 ’-naphthylalanine (Nal(1 ’)), 1 ’-D- naphthylalanine (dNal(1 ’)), Phe, dPhe, and 1 ,2,3,4-tetrahydroisoquinoline carboxylic acid (Tic);R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, dOrn, and ornthine (Orn);Y1is selected from the group consisting of dVal, D-tert-leucine (dTle), dLys, Asp, D- threonine (dThr), p2-valine (p2Val), p3-valine (p3Val), Nle, Trp, dArg, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, p-proline (pPro), Nle, and valine (Vai);Y3is absent or selected from the group consisting of dVal, dThr, dPro, and Pro;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R1or R2and R7when R1or R2is Asp or CO-cis- CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen,-223-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO provided that the non-naturally occurring melanocortin analog does not comprise a sequence selected from the group consisting of:Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-Arg-NH2(SEQ ID NO: 6);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Asp-dPro-NH2(SEQ ID NO: 7);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dPro-NH2(SEQ ID NO: 3);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Asp-NH2(SEQ ID NO: 8);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 9);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Lys-dPro-dVal-NH2(SEQ ID NO: 10);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dLys-dPro-dVal-NH2(SEQ ID NO: 11 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Lys-dPro-NH2(SEQ ID NO: 12);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Lys-Val-Pro-NH2(SEQ ID NO: 13);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Lys-dVal-dPro-NH2(SEQ ID NO: 14);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dPro-dVal-NH2(SEQ ID NO: 15);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dVal-dPro-NH2(SEQ ID NO: 16);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 17);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dVal-NH2(SEQ ID NO: 18);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dTle-NH2(SEQ ID NO: 19);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dTle-dPro-NH2(SEQ ID NO: 20);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 21 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dPro-dTle-NH2(SEQ ID NO: 22);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dTle-NH2(SEQ ID NO: 23);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 24);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-dVal-dPro-NH2(SEQ ID NO: 25);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Trp-NH2(SEQ ID NO: 26);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dTle-dPro-NH2(SEQ ID NO: 27);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dVal-NH2(SEQ ID NO: 28);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-NH2(SEQ ID NO: 29);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dLys-dPro-NH2(SEQ ID NO: 30);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dLys-dVal-dPro-NH2(SEQ ID NO: 31 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dVal-dPro-NH2(SEQ ID NO: 32);Ac-Nle-c[Asp-His-dNal(2')-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 33);-224-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Asp-dVal-dPro-NH2(SEQ ID NO: 34);Ac-Nle-c[Asp-Pro-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 35);Ac-Nle-c[Asp-Pro-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 36);Ac-Nle-c[Asp-Pro-dNal(2')-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 37);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Nal(1 ’)-Lys]-dVal-dPro-NH2(SEQ ID NO: 38);Ac-Nle-c[Asp-Hyp-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 39);Ac-Nle-c[Asp-Hyp-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 40);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Phe-Lys]-dVal-dPro-NH2(SEQ ID NO: 41 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-dPhe-Lys]-dVal-dPro-NH2(SEQ ID NO: 42);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-dNal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 43);Ac-Nle-c[Asp-His-dNal(2')-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 44);Ac-dVal-dPro-c[Lys-Trp-Arg-dNal(2')-His-Asp]-Nle-Nle-NH2(SEQ ID NO: 45);Ac-dVal-dPro-c[Asp-Trp-Arg-dNal(2')-His-Lys]-Nle-Nle-NH2(SEQ ID NO: 46);Ac-Nle-c[Asp-His-dNal(2')-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 47);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Nal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 48);Ac-Arg-c[Glu-Pro-His-dNal(2')-His-Trp-Orn]-dVal-dPro-NH2(SEQ ID NO: 49);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dPro-NH2(SEQ ID NO: 3);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-dCys]-dArg-dPro-NH2(SEQ ID NO: 50);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 51 );Ac-His-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 52);Ac-dHis-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 53);Ac-Nle-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 54);Ac-Nle-c[Asp-Pro-p(F)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 55);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 56);Ac-Nle-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 57);Ac-dArg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 58);Ac-Arg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 59);Ac-His-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 60);Ac-dHis-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 61 );Ac-Nle-c[Cys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 62);Ac-Nle-c[dCys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 63);-225-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[dCys-His-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 64);Ac-dArg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 65);Ac-Arg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 66);Ac-His-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 67);Ac-dHis-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 68);Ac-Nle-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 69);Ac-Nle-c[Asp-His-p(F)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 70);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 71 );Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 72);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 73);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 74);Ac-Nle-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 75);Ac-dArg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 76);Ac-Arg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 77);Ac-His-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 78);Ac-dHis-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 79);Ac-Nle-c[Cys-Pro-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 80);Ac-Nle-c[dCys-Pro-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 81 );Ac-Nle-c[dCys-Pro-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 82);Ac-dArg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 83);Ac-Arg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 84);Ac-Nle-c[Asp-Bip-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 85);Ac-Nle-c[Asp-dGln-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 86);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 87);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Orn]-dVal-dPro-NH2(SEQ ID NO: 88);Ac-Nle-c[Asp-Trp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 89); c[CO-cis-CH=CH-CO-Pro-p(F)dPhe-Arg-Trp-l_ys]-dVal-dPro-NH2(SEQ ID NO: 90); c[CO-cis-CH=CH-CO-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 91 );Ac-Nle-c[Asp-[3-Ala-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 92);Ac-Nle-c[Pen-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 93);Ac-Nle-c[Asp-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 94);-226-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Mamb-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 95);Ac-Nle-c[Asp-His-p(F)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 96);Ac-Nle-c[Asp-Pro-p(F)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 97);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 98);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 99);Ac-dVal-dPro-c[Lys-Trp-Arg-p(F)dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 100);Ac-dVal-dPro-c[Asp-Trp-Arg-p(F)dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 101 );Ac-dVal-dPro-c[Lys-Trp-Arg-p(F)dPhe-His-Asp]-Nle-Nle-NH2(SEQ ID NO: 102);Ac-dVal-dPro-c[Asp-Trp-Arg-p(F)dPhe-His-Lys]-Nle-Nle-NH2(SEQ ID NO: 103);Ac-Nle-c[Asp-Pro-d(F);Phe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 104);Ac-Nle-c[Asp-Pro-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 105);Ac-dPhe-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 106);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 107);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 108);Ac-Nle-c[Pen-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 93);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 109);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 110);Ac-Nle-c[Cys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 111 );Ac-Nle-c[dCys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 112);Ac-Nle-c[dCys-His-p(CI)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 113);Ac-Arg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 114);Ac-His-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 115);Ac-dHis-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 1 16);Ac-Nle-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 117);Ac-Nle-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 118);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 1 19);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 120);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 121 );Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 122);Ac-Nle-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 123);Ac-dArg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 124);-227-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Arg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 125);Ac-His-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 126);Ac-dHis-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 127);Ac-Nle-c[Asp-dGln-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 128);Ac-Nle-c[Asp-dTrp-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 129);Ac-Nle-c[Asp-Bip-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 130);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Orn]-dVal-dPro-NH2(SEQ ID NO: 131 );Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-NH2(SEQ ID NO: 132); c[CO-cis-CH=CH-CO-Pro-p(CI)dPhe-Arg-Trp-l_ys]-dVal-dPro-NH2(SEQ ID NO: 133);Ac-Nle-c[Asp-Pro-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 134);Ac-Nle-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 118);Ac-Arg-c[Asp-Pro-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 135);Ac-Arg-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 136);Ac-Nle-c[Asp-Trp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 137); c[CO-cis-CH=CH-CO-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 138);Ac-Nle-c[Asp-[3-Ala-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 139);Ac-Nle-c[Pen-p(CI)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 140);Ac-Nle-c[Asp-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 141 );Ac-Nle-c[Asp-Mamb-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 142);Ac-Nle-c[Asp-His-p(CI)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 143);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 144);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 145);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 146);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 147);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 148);Ac-dVal-dPro-c[Lys-Trp-Arg-p(CI)dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 149);Ac-dVal-dPro-c[Asp-Trp-Arg-p(CI)dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 150);Ac-dVal-dPro-c[Lys-Trp-Arg-p(CI)dPhe-His-Asp]-Nle-Nle-NH2(SEQ ID NO: 151 );Ac-dVal-dPro-c[Asp-Trp-Arg-p(CI)dPhe-His-Lys]-Nle-Nle-NH2(SEQ ID NO: 152);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 153);Ac-Nle-c[Asp-Pro-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 154);-228-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Cys-His-p(Br)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2 (SEQ ID NO: 155);Ac-dArg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 156);Ac-Arg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 157);Ac-His-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 158);Ac-dHis-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 159);Ac-Nle-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 160);Ac-Nle-c[Asp-His-p(Br)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 161 );Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 162);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 163);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 164);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 165);Ac-Nle-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 166);Ac-dArg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 167);Ac-Arg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 168);Ac-Nle-c[Asp-dBip-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 169);Ac-Nle-c[Asp-Pro-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 170);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 171 );Ac-Nle-c[Asp-His-Arg-p(l)dPhe-Arg-Tic-Lys]-dVal-dPro-NH2(SEQ ID NO: 172);Ac-Nle-c[Asp-Pro-Arg-p(l)dPhe-Arg-Tic-Lys]-dVal-dPro-NH2(SEQ ID NO: 173);Ac-Nle-c[Asp-Pro-p(l)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 174);Ac-Nle-c[Asp-His-p(l)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 175);Ac-Nle-c[Asp-Pro-dBip-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 176);Ac-Nle-c[Lys-His-Arg-dBip-Arg-Tic-Asp]-dVal-dPro-NH2 (SEQ ID NO: 177);Ac-Nle-c[Lys-Pro-Arg-dBip-Arg-Tic-Asp]-dVal-dPro-NH2 (SEQ ID NO: 178);Ac-dArg-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 179);Ac-dNle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 180);Ac-dPro-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 181 );Ac-Nle-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 182);Ac-Nle-Nle-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 183);Ac-dVal-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 184);Ac-dNle-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 185);-229-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-dArg-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2 (SEQ ID NO: 186);Ac-Arg-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 187);Ac-dHis-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 188);Ac-His-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 189);Ac-Asp-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 190);Ac-Arg-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 191 );Ac-His-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 192);Ac-dHis-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 193);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 194);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 195);Ac-dPhe-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 196);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dVal-dPro-NH2(SEQ ID NO: 197);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 198);Ac-Nle-c[Asp-Pro-dNal(2')-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 199);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Gly-Lys]-dVal-dPro-NH2(SEQ ID NO: 200);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 201 );Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 202);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 203);Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 204);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 205);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 206);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 207);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 208);Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 209);Ac-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 210);Ac-Nle-c[Asp-Pro-dNal(2')-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 211 );Ac-Nle-c[Asp-Ala-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 212);Ac-Nle-c[Asp-Gly-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 213);Ac-Nle-c[Asp-Leu-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 214);Ac-dPhe-c[Asp-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 215); c[CO-cis-CH=CH-CO-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 216);-230-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[dCys-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 217);Ac-Nle-c[Cys-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 218);Ac-Nle-c[Asp-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 219);Ac-Nle-c[Asp-Glu-His-dNal(2')-Arg-Trp-Gly-Lys]-dVal-dPro-NH2(SEQ ID NO: 220);Ac-Nle-c[Asp-Pro-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 221 );Ac-Nle-c[dPen-Pro-dPhe-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 222);Ac-Nle-c[dCys-Pro-dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 223);Ac-Nle-c[Asp-Pro-dPhe-Arg-Nal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 224);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dThr-dPro-dThr-OH (SEQ ID NO: 225);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 226);His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 227); dPhe-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 228); dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 229);Ac-Nle-c[Asp-Pro-dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 230);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 231 );Ac-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 232);Ac-dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 233);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dArg-dVal-dPro-NH2(SEQ ID NO: 234);Ac-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dLys-dPro-NH2(SEQ ID NO: 235);Ac-Nle-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 236);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dArg-dPro-NH2(SEQ ID NO: 237);Ac-dArg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 238);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 239);Ac-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 240);Ac-dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 241 );Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 242);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dVal-dPro-NH2(SEQ ID NO: 243);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dLys-dVal-dPro-NH2(SEQ ID NO: 244);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dArg-dVal-dPro-NH2(SEQ ID NO: 245);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 246);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dTle-dPro-NH2(SEQ ID NO: 247);-231 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 248);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dTle-NH2(SEQ ID NO: 249);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dPro-NH2(SEQ ID NO: 250);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 251 );Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-dVal-dPro-NH2(SEQ ID NO: 252);Ac-dArg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 253);Ac-Nle-Nle-Nle-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 254);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Trp-NH2(SEQ ID NO: 255);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Gly-Lys]-dVal-dPro-NH2(SEQ ID NO: 256);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dPro-dVal-NH2(SEQ ID NO: 257);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dPro-NH2(SEQ ID NO: 258);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 4);Ac-Nle-c[dCys-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 259);Ac-Nle-c[Asp-Pro-dPhe-Arg-Phe-Lys]-dVal-dPro-NH2(SEQ ID NO: 261 );Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 262); c[CO-cis-CH=CH-CO-Pro-dPhe-Arg-Trp-l_ys]-dVal-dPro-NH2(SEQ ID NO: 263);Ac-Asp-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 264);Ac-dVal-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 265);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 266);Ac-Nle-c[Asp-Pro-dPhe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 267);Ac-Nle-c[Asp-dPhe-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 268);Ac-Nle-c[Asp-dTyr-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 269);Ac-Nle-c[Asp-dGln-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 270);Ac-Nle-c[Asp-dTrp-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 271 );Ac-Nle-c[Asp-Bip-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 272);Ac-Nle-c[Asp-Leu-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 273);Ac-dHis-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 274);Ac-His-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 275);Ac-Nle-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 276);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dArg-dVal-dPro-NH2(SEQ ID NO: 277);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dLys-dVal-dPro-NH2(SEQ ID NO: 278);-232-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dArg-dPro-NH2 (SEQ ID NO: 279);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dLys-dPro-NH2 (SEQ ID NO: 280);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 281 );Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 282);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 283);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 284);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Pro-Lys]-dVal-dPro-NH2 (SEQ ID NO: 285);Ac-Nle-c[dPen-dPhe-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 286);Ac-Nle-c[Asp-Hyp-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 287);Ac-Nle-c[Asp-Pro-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 288);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 289);Ac-Nle-c[Cys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2 (SEQ ID NO: 290);Ac-Nle-c[dCys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2 (SEQ ID NO: 291 );Ac-Arg-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 292);Ac-dArg-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 293);Ac-Asp-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 294);Ac-His-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 295);Ac-Nle-c[Asp-Gly-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 296);Ac-Nle-c[Asp-dLeu-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 297);Ac-Nle-c[Asp-dMet-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 298); c[CO-cis-CH=CH-CO-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 299);Ac-Nle-c[Asp-p-Ala-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 300);Ac-Nle-c[Asp-Mamb-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 301 );Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dArg-NH2 (SEQ ID NO: 302);Ac-dVal-dPro-c[Lys-Trp-Arg-dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 303);Ac-dVal-dPro-c[Asp-Trp-Arg-dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 304);Ac-dVal-dPro-c[Lys-Trp-Arg-dPhe-His-Asp]-Nle-Nle-NH2(SEQ ID NO: 305);Ac-dVal-dPro-c[Asp-Trp-Arg-dPhe-His-Lys]-Nle-Nle-NH2(SEQ ID NO: 306);Ac-Arg-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 307);Ac-Nle-c[Asp-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 308);Ac-Arg-c[Asp-Pro-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 309);-233-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Arg-c[Asp-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 310);Ac-Nle-c[Asp-dAla-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 311 );Ac-Nle-c[Pen-dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 312);Ac-Nle-c[Asp-His-dPhe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 313);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 314); and Ac-Arg-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 315), wherein c represents cyclization via a lactam or disulfide bond.

28. The pharmaceutical composition of any one of claims 1 -27, wherein the non- naturally occurring melanocortin analog comprises a sequence of Formula (IA):X1-X2-X3- R1- R2- R3- R4- R5-R6-R7-Y1-Y2-Y3-Y4( I A) , wherein:X1is absent, dVal, or Nle;X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of Asp, Nle, dNIe, His, dHis, dPhe, Arg, dPro, and dArg;R2is selected from the group consisting of Asp, Pro, Lys, Cys, dCys, dPen, Pen, Glu and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, Trp-Pro, dAla, dMet, Gly, Gly-Gly, p-Ala, Mamb, Cpe, Che, Pro-Pro, Pro-His, Pro-Glu, Arg, dPhe, dBip, dTyr, Leu, dLeu, dVal, Trp-Arg, and Ala;R4is selected from the group consisting of dNal(2’), dPhe, p(F)dPhe, p(CI)dPhe, and p(Br)dPhe;R5is absent or selected from the group consisting of Arg, dLys, dArg, dOrn, Glu, dAsp, dGlu, Pro, and His;R6is absent or is selected from the group consisting of Trp, Trp-Gly, Trp-Pro, Nal(2’), and Nal(1 ’);R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, dOrn, and Orn;-234-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOY1is selected from the group consisting of dVal, dTle, dLys, Asp, dThr, p2Val, p3Val, Nle, Trp, dArg, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, pPro, Nle, and Vai;Y3is absent or selected from the group consisting of dVal, dThr, dPro, and Pro;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R1or R2and R7when R1or R2is Asp or CO-cis- CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that: when R4is dNal(2’), then R3is not Pro-His or Pro-Pro, R1is not dArg, R5is not His, R6is not Phe, dPhe, Nal (1 ’), or dNal(1 ’), and either (i) Y1is dVal, Y2is dPro, and Y3-Y4are absent (ii) Y1is dLys or dArg, and R2is dPen, (iii) Y1is Nle, Y2is absent, and R2is Lys, or (iv) Y1is Nle, Y2is Nle, and R2is Asp, when R4is p(F)dPhe, then R3is Pro, and either (i) R6is not Trp or (ii) Y1and Y2are each independently dVal or dTle, when R4is p(CI)dPhe, then R3is His, R1is dArg, and Y1is dVal, when R4is p(Br)dPhe, then R3is dTyr or His, wherein when R3is His then either (i) R1is His or dHis and Y1is dTle or (ii) R2is dCys and R7is Cys, when R4is dNal(2’) and R3is Pro, then R1is absent, dPhe, or Nle and R6is Trp, wherein when R1is absent, then R2is CO-cis-CH=CH-CO, when R1is dPhe, then R2is dPen, and when R1is Nle, then (i) R2is Asp and either (a) R5is not Arg, Pro, or absent, (b) R7is not Lys, or (c) X1-X3are all Nle, (ii) R2and R7are each is dPen or (iii) R2is Pen or Cys, and R7is dCys,-235-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO when R4is dNal(2’) and R3is Ala, Leu, dLeu, dVal, Gly, or His, then either R2is dPen or R6is Trp-Pro, when R4is dNal(2’) and R3is absent, then (i) R2is not Asp, (ii) R2and R7are not both Cys, and (iii) when R2is dCys, then R7is dCys, when R4is dPhe and R3is Pro, then the N-terminus is acetylated, X1-X2are each independently absent or Nle, X3is absent, R1is dNIe, dPhe or Nle, R2is Cys or Asp, R5is Arg or Pro, R6is Trp or dNal(l ’), the C-terminus is amidated, wherein when R1is Nle, then either (i) Y1is dVal, Y2is dPro and at least one of X1-X2is Nle, (ii) Y1is dVal or Lys and Y2is dArg or Vai, or (iii) Y1is dLys, Asp, dThr, p2Val, or p3Val, and Y2is not dVal, and when R4is dPhe, and R3is not Pro, then the N-terminus is acetylated, X1-X3are absent, R1is absent, Nle, Arg, or dArg, Y1is dVal, Y2is dPro and Y3-Y4are absent, and either (i) R3is absent and R7is Cys, (ii) R3is Trp-Pro and either R5is His, or R6is Nal(1 ’), (iii) R3is Pro-His, R1is Nle and R5is His, (iv) R3is dAla and R1is Arg, or (vi) R3is selected from dBip, Pro-Pro, and Arg.

29. The pharmaceutical composition of any one of claims 1 -28, wherein the non- naturally occurring melanocortin analog comprises a sequence of Formula (IA), wherein:X1is absent, dVal, or Nle;X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of Asp, Nle, dNIe, His, dHis, dPhe, Arg, dPro, and dArg;R2is selected from the group consisting of Asp, Pro, Lys, Cys, dCys, dPen, Pen, Glu and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, Trp-Pro, dAla, dMet, Gly, Gly-Gly, p-Ala, Mamb, Cpe, Che, Pro-Pro, Pro-His, Pro-Glu, Arg, dPhe, dBip, dTyr, Leu, dLeu, dVal, Trp-Arg, and Ala;R4is selected from the group consisting of dNal(2’), dPhe, p(F)dPhe, p(CI)dPhe, and p(Br)dPhe;R5is absent or selected from the group consisting of Arg, dLys, dArg, dOrn, Glu, dAsp, dGlu, Pro, and His;-236-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOR6is absent or is selected from the group consisting of Trp, Trp-Gly, Trp-Pro, Nal(2’), and Nal(1 ’);R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, dOrn, and Orn;Y1is selected from the group consisting of dVal, dTle, dLys, Asp, dThr, p2Val, p3Val, Nle, Trp, dArg, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, pPro, Nle, and Vai;Y3is absent or selected from the group consisting of dVal, dThr, dPro, and Pro;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R1or R2and R7when R1or R2is Asp or CO-cis- CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that the non-naturally occurring melanocortin analog does not comprise a sequence selected from the group consisting of: Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-Arg-NH2(SEQ ID NO: 6);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Asp-dPro-NH2(SEQ ID NO: 7);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dPro-NH2(SEQ ID NO: 3);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Asp-NH2(SEQ ID NO: 8);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 9);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Lys-dPro-dVal-NH2(SEQ ID NO: 10);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dLys-dPro-dVal-NH2(SEQ ID NO: 11 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Lys-dPro-NH2(SEQ ID NO: 12);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Lys-Val-Pro-NH2(SEQ ID NO: 13);-237-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Lys-dVal-dPro-NH2(SEQ ID NO: 14);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dPro-dVal-NH2(SEQ ID NO: 15);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dVal-dPro-NH2(SEQ ID NO: 16);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 17);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dVal-NH2(SEQ ID NO: 18);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dTle-NH2(SEQ ID NO: 19);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dTle-dPro-NH2(SEQ ID NO: 20);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 21 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dPro-dTle-NH2(SEQ ID NO: 22);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dTle-NH2(SEQ ID NO: 23);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 24);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-dVal-dPro-NH2(SEQ ID NO: 25);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Trp-NH2(SEQ ID NO: 26);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dTle-dPro-NH2(SEQ ID NO: 27);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dVal-NH2(SEQ ID NO: 28);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-NH2(SEQ ID NO: 29);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dLys-dPro-NH2(SEQ ID NO: 30);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dLys-dVal-dPro-NH2(SEQ ID NO: 31 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dVal-dPro-NH2(SEQ ID NO: 32);Ac-Nle-c[Asp-His-dNal(2')-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 33);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-Asp-dVal-dPro-NH2(SEQ ID NO: 34);Ac-Nle-c[Asp-Pro-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 35);Ac-Nle-c[Asp-Pro-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 36);Ac-Nle-c[Asp-Pro-dNal(2')-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 211 );Ac-Nle-c[Asp-Pro-dNal(2')-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 37);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Nal(1 ’)-Lys]-dVal-dPro-NH2(SEQ ID NO: 38);Ac-dVal-dPro-c[Lys-Trp-Arg-dNal(2')-His-Asp]-Nle-Nle-NH2(SEQ ID NO: 45);Ac-dVal-dPro-c[Asp-Trp-Arg-dNal(2')-His-Lys]-Nle-Nle-NH2(SEQ ID NO: 46);Ac-Nle-c[Asp-His-dNal(2')-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 44);Ac-Nle-c[Asp-His-dNal(2')-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 47);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Nal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 48);-238-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Arg-c[Glu-Pro-His-dNal(2')-His-Trp-Orn]-dVal-dPro-NH2(SEQ ID NO: 49);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dPro-NH2(SEQ ID NO: 3);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-dCys]-dArg-dPro-NH2(SEQ ID NO: 50);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 51 );Ac-His-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 52);Ac-dHis-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 53);Ac-Nle-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 54);Ac-Nle-c[Asp-Pro-p(F)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 55);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 56);Ac-Nle-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 57);Ac-dArg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 58);Ac-Arg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 59);Ac-His-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 60);Ac-dHis-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 61 );Ac-Nle-c[Cys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 62);Ac-Nle-c[dCys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 63);Ac-Nle-c[dCys-His-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 64);Ac-dArg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 65);Ac-Arg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 66);Ac-His-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 67);Ac-dHis-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 68);Ac-Nle-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 69);Ac-Nle-c[Asp-His-p(F)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 70);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 71 );Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 72);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 73);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 74);Ac-Nle-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 75);Ac-dArg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 76);Ac-Arg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 77);Ac-His-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 78);-239-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-dHis-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 79);Ac-Nle-c[Cys-Pro-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 80);Ac-Nle-c[dCys-Pro-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 81 );Ac-Nle-c[dCys-Pro-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 82);Ac-dArg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 83);Ac-Arg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 84);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 87);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Orn]-dVal-dPro-NH2(SEQ ID NO: 88);Ac-Nle-c[Asp-Trp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 89); c[CO-cis-CH=CH-CO-Pro-p(F)dPhe-Arg-Trp-l_ys]-dVal-dPro-NH2(SEQ ID NO: 90); c[CO-cis-CH=CH-CO-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 91 );Ac-Nle-c[Asp-[3-Ala-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 92);Ac-Nle-c[Pen-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 93);Ac-Nle-c[Asp-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 94);Ac-Nle-c[Asp-Mamb-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 95);Ac-Nle-c[Asp-His-p(F)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 96);Ac-Nle-c[Asp-Pro-p(F)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 97);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 98);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 99);Ac-dVal-dPro-c[Lys-Trp-Arg-p(F)dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 100);Ac-dVal-dPro-c[Asp-Trp-Arg-p(F)dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 101 );Ac-dVal-dPro-c[Lys-Trp-Arg-p(F)dPhe-His-Asp]-Nle-Nle-NH2(SEQ ID NO: 102);Ac-dVal-dPro-c[Asp-Trp-Arg-p(F)dPhe-His-Lys]-Nle-Nle-NH2(SEQ ID NO: 103);Ac-Nle-c[Asp-Pro-d(F);Phe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 104);Ac-Nle-c[Asp-Pro-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 105);Ac-dPhe-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 106);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 107);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 108);Ac-Nle-c[Pen-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 93);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 109);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 110);-240-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Cys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 111 );Ac-Nle-c[dCys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 112);Ac-Nle-c[dCys-His-p(CI)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 113);Ac-Arg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 114);Ac-His-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 115);Ac-dHis-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 1 16);Ac-Nle-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 117);Ac-Nle-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 118);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 1 19);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 120);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 121 );Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 122);Ac-Nle-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 123);Ac-dArg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 124);Ac-Arg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 125);Ac-His-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 126);Ac-dHis-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 127);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Orn]-dVal-dPro-NH2(SEQ ID NO: 131 );Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-NH2(SEQ ID NO: 132); c[CO-cis-CH=CH-CO-Pro-p(CI)dPhe-Arg-Trp-l_ys]-dVal-dPro-NH2(SEQ ID NO: 133);Ac-Nle-c[Asp-Pro-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 134);Ac-Nle-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 118);Ac-Arg-c[Asp-Pro-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 135);Ac-Arg-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 136);Ac-Nle-c[Asp-Trp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 137); c[CO-cis-CH=CH-CO-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 138);Ac-Nle-c[Asp-[3-Ala-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 139);Ac-Nle-c[Pen-p(CI)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 140);Ac-Nle-c[Asp-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 141 );Ac-Nle-c[Asp-Mamb-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 142);Ac-Nle-c[Asp-His-p(CI)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 143);-241 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Pro-p(CI)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 144);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 145);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 146);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 147);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 148);Ac-dVal-dPro-c[Lys-Trp-Arg-p(CI)dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 149);Ac-dVal-dPro-c[Asp-Trp-Arg-p(CI)dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 150);Ac-dVal-dPro-c[Lys-Trp-Arg-p(CI)dPhe-His-Asp]-Nle-Nle-NH2(SEQ ID NO: 151 );Ac-dVal-dPro-c[Asp-Trp-Arg-p(CI)dPhe-His-Lys]-Nle-Nle-NH2(SEQ ID NO: 152);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 153);Ac-Nle-c[Asp-Pro-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 154);Ac-Nle-c[Cys-His-p(Br)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 155);Ac-dArg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 156);Ac-Arg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 157);Ac-His-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 158);Ac-dHis-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 159);Ac-Nle-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 160);Ac-Nle-c[Asp-His-p(Br)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 161 );Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 162);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 163);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 164);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 165);Ac-Nle-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 166);Ac-dArg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 167);Ac-Arg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 168);Ac-Nle-c[Asp-dBip-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 169);Ac-Nle-c[Asp-Pro-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 170);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 171 );Ac-dArg-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 179);Ac-dNle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 180);Ac-dPro-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 181 );-242-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 182);Ac-Nle-Nle-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 183);Ac-dVal-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 184);Ac-dNle-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 185);Ac-dArg-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 186);Ac-Arg-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 187);Ac-dHis-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 188);Ac-His-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 189);Ac-Asp-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 190);Ac-Arg-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 191 );Ac-His-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 192);Ac-dHis-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 193);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 194);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 195);Ac-dPhe-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 196);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dVal-dPro-NH2(SEQ ID NO: 197);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 198);Ac-Nle-c[Asp-Pro-dNal(2')-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 199);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Gly-Lys]-dVal-dPro-NH2(SEQ ID NO: 200);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 201 );Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 202);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 203);Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 204);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 205);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 206);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 207);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 208);Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 209);Ac-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 210);Ac-Nle-c[Asp-Ala-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 212);Ac-Nle-c[Asp-Gly-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 213);-243-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Leu-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 214);Ac-dPhe-c[Asp-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 215); c[CO-cis-CH=CH-CO-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 216);Ac-Nle-c[dCys-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 217);Ac-Nle-c[Cys-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 218);Ac-Nle-c[Asp-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 219);Ac-Nle-c[Asp-Pro-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 221 );Ac-Nle-c[dPen-Pro-dPhe-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 222);Ac-Nle-c[dCys-Pro-dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 223);Ac-Nle-c[Asp-Pro-dPhe-Arg-Nal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 224);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dThr-dPro-dThr-OH (SEQ ID NO: 225);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 226);His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 227); dPhe-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 228); dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 229);Ac-Nle-c[Asp-Pro-dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 230);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 231 );Ac-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 232);Ac-dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 233);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dArg-dVal-dPro-NH2(SEQ ID NO: 234);Ac-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dLys-dPro-NH2(SEQ ID NO: 235);Ac-Nle-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 236);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dArg-dPro-NH2(SEQ ID NO: 237);Ac-dArg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 238);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 239);Ac-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 240);Ac-dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 241 );Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 242);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dVal-dPro-NH2(SEQ ID NO: 243);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dLys-dVal-dPro-NH2(SEQ ID NO: 244);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dArg-dVal-dPro-NH2(SEQ ID NO: 245);-244-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 246);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dTle-dPro-NH2 (SEQ ID NO: 247);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 248);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dTle-NH2(SEQ ID NO: 249);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dPro-NH2(SEQ ID NO: 250);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 251 );Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-dVal-dPro-NH2(SEQ ID NO: 252);Ac-dArg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 253);Ac-Nle-Nle-Nle-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 254);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Trp-NH2 (SEQ ID NO: 255);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Gly-Lys]-dVal-dPro-NH2(SEQ ID NO: 256);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dPro-dVal-NH2 (SEQ ID NO: 257);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dPro-NH2 (SEQ ID NO: 258);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 4);Ac-Nle-c[dCys-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 259);Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 262); c[CO-cis-CH=CH-CO-Pro-dPhe-Arg-Trp-l_ys]-dVal-dPro-NH2(SEQ ID NO: 263);Ac-Asp-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 264);Ac-dVal-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 265);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 266);Ac-Nle-c[Asp-Pro-dPhe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 267);Ac-Nle-c[Asp-dPhe-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 268);Ac-Nle-c[Asp-dTyr-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 269);Ac-Nle-c[Asp-Leu-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 273);Ac-dHis-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 274);Ac-His-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 275);Ac-Nle-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 276);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dArg-dVal-dPro-NH2 (SEQ ID NO: 277);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dLys-dVal-dPro-NH2 (SEQ ID NO: 278);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dArg-dPro-NH2 (SEQ ID NO: 279);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dLys-dPro-NH2 (SEQ ID NO: 280);-245-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2 (SEQ ID NO: 281 );Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 282);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 283);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 284);Ac-Nle-c[dPen-dPhe-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 286);Ac-Nle-c[Asp-Pro-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 288);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 285);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 289);Ac-Nle-c[Cys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 290);Ac-Nle-c[dCys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 291 );Ac-Arg-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 292);Ac-dArg-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 293);Ac-Asp-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 294);Ac-His-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 295);Ac-Nle-c[Asp-Gly-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 296);Ac-Nle-c[Asp-dLeu-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 297);Ac-Nle-c[Asp-dMet-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 298); c[CO-cis-CH=CH-CO-His-dPhe-Arg-Trp-l_ys]-dVal-dPro-NH2(SEQ ID NO: 299);Ac-Nle-c[Asp-p-Ala-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 300);Ac-Nle-c[Asp-Mamb-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 301 );Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dArg-NH2(SEQ ID NO: 302);Ac-dVal-dPro-c[Lys-Trp-Arg-dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 303);Ac-dVal-dPro-c[Asp-Trp-Arg-dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 304);Ac-dVal-dPro-c[Lys-Trp-Arg-dPhe-His-Asp]-Nle-Nle-NH2(SEQ ID NO: 305);Ac-dVal-dPro-c[Asp-Trp-Arg-dPhe-His-Lys]-Nle-Nle-NH2(SEQ ID NO: 306);Ac-Arg-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 307);Ac-Nle-c[Asp-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 308);Ac-Arg-c[Asp-Pro-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 309);Ac-Arg-c[Asp-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 310);Ac-Nle-c[Asp-dAla-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 311 );Ac-Nle-c[Pen-dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 312);-246-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-His-dPhe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 313);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 314);Ac-Arg-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 315);Ac-Nle-c[Asp-His-dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 316);Ac-Nle-c[Asp-His-dNal(2')-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 317);Ac-dArg-c[Asp-dAla-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 318);Ac-dVal-dPro-c[Asp-Trp-Arg-dNal(2')-Pro-Lys]-Nle-NH2(SEQ ID NO: 319);Ac-dVal-dPro-c[Lys-Trp-Arg-dNal(2')-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 320);Ac-Nle-c[dCys-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 321 );Ac-Nle-c[Asp-dLeu-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 322);Ac-Nle-c[Asp-dVal-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 323);Ac-Nle-c[Asp-dPhe-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 324);Ac-Nle-c[Asp-dBip-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 325);Ac-Nle-c[Asp-dTyr-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 326);Ac-Nle-c[dCys-His-p(Br)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 327);Ac-Nle-c[Asp-dVal-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 328);Ac-Nle-c[Asp-dPhe-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 329);Ac-Nle-c[Asp-dPhe-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 330);Ac-Nle-c[Asp-dBip-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 331 );Ac-Nle-c[Asp-dTyr-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 332);Ac-Nle-c[dCys-Trp-Pro-dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 333);Ac-Nle-c[Asp-Cpe-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 334);Ac-Nle-c[Asp-Che-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 335);Ac-dArg-c[Asp-dAla-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 336); and Ac-Nle-c[Cys-dPhe-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 337), wherein c represents cyclization via a lactam or disulfide bond.

30. The pharmaceutical composition of any one of claims 1 -29, wherein the non- naturally occurring melanocortin analog comprises a sequence of Formula (I A(i)) :X1-X2-X3- R1- R2- R3- R4- R5- R6- R7-Y1-Y2-Y3( I A(i)) , wherein:-247-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOX1is absent, dVal, or Nle;X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of Nle, Arg, dPhe, and dPro;R2is selected from the group consisting of Asp, Lys, Cys, dCys, dPen, Pen, and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, Trp-Pro, dAla, dMet, Gly, Gly-Gly, p-Ala, Mamb, Cpe, Che, Pro-Glu, Leu, dLeu, dVal, Trp-Arg, and Ala;R4is dNal(2’);R5is selected from the group consisting of Arg, dLys, dArg, dOrn, Glu, dAsp, dGlu, and Pro;R6is absent or is selected from the group consisting of Trp, Trp-Gly, and Trp-Pro;R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, and dOrn;Y1is selected from the group consisting of dVal, dLys, dArg, and Nle;Y2is absent or selected from dPro, dVal, and Nle;Y3is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R2and R7when R2is Asp or CO-cis-CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, and a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that: when R3is Pro, then R1is absent, dPhe, or Nle and R6is Trp, wherein when R1is absent, then R2is CO-cis-CH=CH-CO, when R1is dPhe, then R2is dPen, and when R1is Nle, then (i) R2is Asp and either (a) R5is not Arg, Pro, or absent, (b) R7is not Lys, or (c) X1-X3are all Nle, (ii) R2and R7are each is dPen or (iii) R2is Pen or Cys, and R7is dCys, when R3is Ala, Leu, dLeu, dVal, Gly, or His, then either R2is dPen or R6is Trp-Pro,-248-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO when R3is absent, then (i) R2is not Asp, (ii) R2and R7are not both Cys, and (iii) when R2is dCys, then R7is dCys, and when R3is Trp-Arg, then Y1is Nle, and either (i) Y2is absent and R2is Lys or (ii) Y2is Nle and R2is Asp.

31. The pharmaceutical composition of any one of claims 1 -30, wherein the non- naturally occurring melanocortin analog comprises a sequence of Formula (I A(i)), wherein:X1is absent, dVal, or Nle;X2is absent or Nle;X3is absent or Nle;R1is absent or is selected from the group consisting of Nle, Arg, dPhe, and dPro;R2is selected from the group consisting of Asp, Lys, Cys, dCys, dPen, Pen, and CO-cis-CH=CH-CO;R3is absent or selected from the group consisting of His, Pro, Trp-Pro, dAla, dMet, Gly, Gly-Gly, p-Ala, Mamb, Cpe, Che, Pro-Glu, Leu, dLeu, dVal, Trp-Arg, and Ala;R4is dNal(2’);R5is selected from the group consisting of Arg, dLys, dArg, dOrn, Glu, dAsp, dGlu, and Pro;R6is absent or is selected from the group consisting of Trp, Trp-Gly, and Trp-Pro;R7is selected from the group consisting of Lys, Asp, Cys, dCys, dPen, Pen, and dOrn;Y1is selected from the group consisting of dVal, dLys, dArg, and Nle;Y2is absent or selected from dPro, dVal, and Nle;Y3is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R2and R7when R2is Asp or CO-cis-CH=CH-CO and R7is Lys or dOrn, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, and-249-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO a disulfide bond between R2and R7, when R2and R7are each independently selected from Cys, dCys, Pen, and dPen, provided that the non-naturally occurring melanocortin analog does not comprise a sequence selected from the group consisting of:Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-NH2(SEQ ID NO: 29);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dLys-dPro-NH2(SEQ ID NO: 30);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dLys-dVal-dPro-NH2(SEQ ID NO: 31 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dArg-dVal-dPro-NH2(SEQ ID NO: 32);Ac-dPro-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 181 );Ac-Nle-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 182);Ac-Nle-Nle-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 183);Ac-dVal-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 184);Ac-Arg-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 187);Ac-Arg-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 191 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 194);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 195);Ac-dPhe-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 196);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dVal-dPro-NH2(SEQ ID NO: 197);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 198);Ac-Nle-c[Asp-Pro-dNal(2')-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 199);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Gly-Lys]-dVal-dPro-NH2(SEQ ID NO: 200);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 201 );Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 202);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 203);Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 204);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 205);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 206);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 207);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 208);Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 209);Ac-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 210);-250-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Ala-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 212);Ac-Nle-c[Asp-Gly-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 213);Ac-Nle-c[Asp-Leu-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 214);Ac-dPhe-c[Asp-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 215); c[CO-cis-CH=CH-CO-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 216); Ac-Nle-c[Asp-His-dNal(2')-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 317);Ac-Nle-c[Asp-dLeu-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 322);Ac-Nle-c[Asp-dVal-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 323);Ac-Nle-c[dCys-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 217);Ac-Nle-c[Cys-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 218);Ac-Nle-c[Asp-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 219);Ac-Nle-c[dCys-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 321 );Ac-dVal-dPro-c[Asp-Trp-Arg-dNal(2')-Pro-Lys]-Nle-NH2(SEQ ID NO: 319); and Ac-dVal-dPro-c[Lys-Trp-Arg-dNal(2')-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 320), wherein c represents cyclization via a lactam or disulfide bond.

32. The pharmaceutical composition of any one of claims 1 -29, wherein the non- naturally occurring melanocortin analog comprises a sequence of Formula (IA(ii)):X1-X2- R1- R2- R3- R4-R5- R6- R7- Y1-Y2-Y3-Y4( I A(i i)) , wherein:X1is absent or Nle;X2is absent or Nle;R1is absent or is selected from the group consisting of Nle, dNIe, His, dHis, dPhe, Arg, and dArg;R2is selected from the group consisting of Asp, Cys, dCys, Pen, and Glu;R3is absent or selected from the group consisting of His, Pro, Trp-Pro, Pro-His, dAla, Pro-Pro, Pro-His, Arg, dBip, and dTyr;R4is selected from the group consisting of dPhe, p(F)dPhe, p(CI)dPhe, and p(Br)dPhe;R5is selected from the group consisting of Arg, Pro, and His;R6is selected from the group consisting of Trp, Nal(2’), and Nal( 1 ’);-251 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOR7is selected from the group consisting of Lys, Cys, and Orn;Y1is selected from the group consisting of dVal, dTle, dLys, Asp, dThr, p2Val, p3Val, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, pPro, and Vai;Y3is absent, dVal, or dThr;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R2and R7when R2is Asp and R7is Lys, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2is Cys, dCys, or Pen and R7is Cys, provided that: when R4is p(F)dPhe, then R3is Pro, and either (i) R6is not Trp or (ii) Y1and Y2are each independently dVal or dTle, when R4is p(CI)dPhe, then R3is His, R1is dArg, and Y1is dVal, when R4is p(Br)dPhe, then R3is dTyr or His, wherein when R3is His then either (i) R1is His or dHis and Y1is dTle or (ii) R2is dCys and R7is Cys, when R4is dPhe and R3is Pro, then the N-terminus is acetylated, R1is dNIe, dPhe or Nle, R2is Cys or Asp, R5is Arg or Pro, R6is Trp, and the C-terminus is amidated, wherein when R1is Nle, then either (i) Y1is dVal, Y2is dPro and at least one of X1-X2is Nle, (ii) Y1is dVal or Lys and Y2is dArg or Vai, or (iii) Y1is dLys, Asp, dThr, p2Val, or p3Val, and Y2is not dVal, when R4is dPhe, and R3is not Pro, then X1-X2are absent, R1is Nle, or Arg, Y1is dVal, Y2is dPro and Y3-Y4are absent, and either (i) R3is absent and R7is Cys, (ii) R3is Trp- Pro and either R5is His, or R6is Nal(1 ’), (iii) R3is Pro-His, R1is Nle and R5is His, (iv) R3is dAla and R1is Arg, or (vi) R3is selected from dBip, Pro-Pro, and Arg.-252-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO33. The pharmaceutical composition of any one of claims 1 -29 and 32, wherein the non-naturally occurring melanocortin analog comprises a sequence of Formula (IA(ii)), wherein:X1is absent or Nle;X2is absent or Nle;R1is absent or is selected from the group consisting of Nle, dNIe, His, dHis, dPhe, Arg, and dArg;R2is selected from the group consisting of Asp, Cys, dCys, Pen, and Glu;R3is absent or selected from the group consisting of His, Pro, Trp-Pro, Pro-His, dAla, Pro-Pro, Pro-His, Arg, dBip, and dTyr;R4is selected from the group consisting of dPhe, p(F)dPhe, p(CI)dPhe, and p(Br)dPhe;R5is selected from the group consisting of Arg, Pro, and His;R6is selected from the group consisting of Trp, Nal(2’), and Nal( 1 ’);R7is selected from the group consisting of Lys, Cys, and Orn;Y1is selected from the group consisting of dVal, dTle, dLys, Asp, dThr, p2Val, p3Val, and Lys;Y2is absent or selected from the group consisting of dPro, dTle, dVal, Arg, pPro, and Vai;Y3is absent, dVal, or dThr;Y4is absent or dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R2and R7when R2is Asp and R7is Lys, a lactam bond between R2and R7, when R2is Glu, R3is Pro-His, and R7is Orn, and a disulfide bond between R2and R7, when R2is Cys, dCys, or Pen and R7is Cys, provided that the non-naturally occurring melanocortin analog does not comprise a sequence selected from the group consisting of: Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 51 );-253-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-His-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 52);Ac-dHis-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 53);Ac-Nle-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 54);Ac-Nle-c[Asp-Pro-p(F)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 55);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 56);Ac-Nle-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 57);Ac-dArg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 58);Ac-Arg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 59);Ac-His-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 60);Ac-dHis-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 61 );Ac-Nle-c[Cys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 62);Ac-Nle-c[dCys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 63);Ac-dArg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 65);Ac-Arg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 66);Ac-His-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 67);Ac-dHis-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 68);Ac-Nle-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 69);Ac-Nle-c[Asp-His-p(F)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 70);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 71 );Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 72);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 73);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 74);Ac-Nle-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 75);Ac-dArg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 76);Ac-Arg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 77);Ac-His-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 78);Ac-dHis-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 79);Ac-Nle-c[Cys-Pro-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 80);Ac-Nle-c[dCys-Pro-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 81 );Ac-dArg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 83);Ac-Arg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 84);-254-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 87);Ac-Nle-c[Asp-Trp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 89);Ac-Nle-c[Asp-His-p(F)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 96);Ac-Nle-c[Asp-Pro-p(F)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 97);Ac-Nle-c[Asp-Pro-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 105);Ac-dPhe-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 106);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 107);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 108);Ac-Nle-c[Pen-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 93);Ac-Nle-c[Asp-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 94);Ac-Nle-c[Pen-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 93);Ac-Nle-c[Asp-dBip-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 331 );Ac-Nle-c[Asp-dTyr-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 332);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 109);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 110);Ac-Nle-c[Cys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 111 );Ac-Nle-c[dCys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 112);Ac-Arg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 114);Ac-His-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 115);Ac-dHis-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 1 16);Ac-Nle-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 117);Ac-Nle-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 118);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 1 19);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 120);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 121 );Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 122);Ac-Nle-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 123);Ac-dArg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 124);Ac-Arg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 125);Ac-His-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 126);Ac-dHis-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 127);-255-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-NH2(SEQ ID NO: 132);Ac-Nle-c[Asp-Pro-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 134);Ac-Nle-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 118);Ac-Arg-c[Asp-Pro-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 135);Ac-Arg-c[Asp-His-p(CI)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 136);Ac-Nle-c[Asp-Trp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 137);Ac-Nle-c[Asp-His-p(CI)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 143);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 144);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 148);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 153);Ac-Nle-c[Asp-Pro-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 154);Ac-Nle-c[Pen-p(CI)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 140);Ac-Nle-c[Asp-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 141 );Ac-Nle-c[Asp-dBip-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 325);Ac-Nle-c[Asp-dTyr-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 326);Ac-Nle-c[Cys-His-p(Br)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 155);Ac-dArg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 156);Ac-Arg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 157);Ac-His-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 158);Ac-dHis-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 159);Ac-Nle-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 160);Ac-Nle-c[Asp-His-p(Br)dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 161 );Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 162);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 163);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 164);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 165);Ac-Nle-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 166);Ac-dArg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 167);Ac-Arg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 168);Ac-Nle-c[Asp-dBip-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 169);Ac-Nle-c[Asp-Pro-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 170);-256-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 171 );Ac-Nle-c[Asp-Pro-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 221 );Ac-Nle-c[Asp-Pro-dPhe-Arg-Nal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 224);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dThr-dPro-dThr-OH (SEQ ID NO: 225);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 226);His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 227); dPhe-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 228); dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 229);Ac-Nle-c[Asp-Pro-dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 230);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 231 );Ac-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 232);Ac-dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 233);Ac-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dLys-dPro-NH2(SEQ ID NO: 235);Ac-Nle-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 236);Ac-dArg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 238);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 239);Ac-His-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 240);Ac-dHis-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 241 );Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dVal-dPro-NH2(SEQ ID NO: 243);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dLys-dVal-dPro-NH2(SEQ ID NO: 244);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 246);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dTle-dPro-NH2(SEQ ID NO: 247);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 248);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dTle-NH2(SEQ ID NO: 249);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dPro-NH2(SEQ ID NO: 250);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 251 );Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-dVal-dPro-NH2(SEQ ID NO: 252);Ac-dArg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 253);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dPro-dVal-NH2(SEQ ID NO: 257);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-dPro-NH2(SEQ ID NO: 258);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 4);-257-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[dCys-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 259);Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 262);Ac-Arg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 266);Ac-Nle-c[Asp-dTyr-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 269);Ac-dHis-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 274);Ac-His-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 275);Ac-Nle-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 276);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dLys-dVal-dPro-NH2(SEQ ID NO: 278);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dLys-dPro-NH2(SEQ ID NO: 280);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 281 );Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 282);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 283);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 284);Ac-Nle-c[Asp-Pro-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 288);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 289);Ac-Nle-c[Cys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 290);Ac-Nle-c[dCys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 291 );Ac-Arg-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 292);Ac-dArg-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 293);Ac-His-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 295);Ac-Arg-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 307);Ac-Nle-c[Asp-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 308);Ac-Arg-c[Asp-Pro-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 309);Ac-Arg-c[Asp-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 310);Ac-Nle-c[Asp-His-dPhe-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 313);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 314);Ac-Arg-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 315);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 147);Ac-Nle-c[Asp-His-dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 316);Ac-Nle-c[dCys-Trp-Pro-dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 333);Ac-dArg-c[Asp-dAla-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 336);-258-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[dPen-dPhe-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 286);Ac-Nle-c[Pen-dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 312); and Ac-Nle-c[Cys-dPhe-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 337), wherein c represents cyclization via a lactam or disulfide bond.

34. The pharmaceutical composition of any one of claims 1 -27, wherein the non- naturally occurring melanocortin analog comprises a sequence of Formula (IB):X1- R1- R2- R3- R4- R5- R6- R7-Y1-Y2(I B) , wherein:X1is absent or dVal;R1is selected from Nle, dArg, and dPro;R2is selected from the group consisting of Asp, Lys, Cys, and dCys;R3is absent or selected from the group consisting of His, Pro, dAla, Trp-Arg, dLeu, dVal, dPhe, Bip, dBip, dTyr, Trp-Pro, Cpe, Che, Phe-Pro, dHis-Pro, dPro, Hyp, His-Arg, Pro-Arg, Arg-Pro, Acpc, Glu-His, Trp-dLeu, Trp-dVal, dlle, dTrp, and dGIn;R4is selected from the group consisting of dNal(2’), Bip, dBip, dPhe, p(F)dPhe, p(CI)dPhe, p(l)dPhe, and p(Br)dPhe;R5is Arg or Pro;R6is absent or is selected from the group consisting of Trp, Trp-Pro, dNal(1 ’), Phe, dPhe, and Tic;R7is selected from the group consisting of Lys, Asp, Cys, dCys, and Pen;Y1is dVal or Nle;Y2is absent, dPro, or Nle; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R2and R7when R2is Asp and R7is Lys, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a disulfide bond between R2and R7, when R2is Cys or dCys and R7is Cys, dCys, or Pen, provided that:-259-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO when R4is dNal(2’), then R3is not Pro, Hyp, dAla, or Trp-Pro, wherein when R3is absent, then R2is dCys and R7is Cys, and when R3is Trp-Arg, then Y1is Nle, and either (i) Y2is absent and R2is Asp or (ii) Y2is Nle and R2is Lys, when R4is p(F)dPhe, then R3is dPhe, d Bip, dTyr, or dTrp, when R4is p(CI)dPhe, then R3is dPhe, dBip, or dTyr, when R4is p(Br)dPhe, then R3is dPhe, Bip, dTrp, dGIn, or His, wherein when R3is His then R7is dCys, when R4is p(l)dPhe, then R3is Arg-Pro, when R4is dBip, then R2is Asp and R3is not Pro, when R4is dPhe, then R3is not Pro, Trp-Arg, dPhe, dTyr, dGIn, dTrp, dLeu, Bip, or dBip, wherein when R3is dAla, then R1is dArg, when R3is His, then R5is Pro, when R3is Hyp, then R6is Trp-Pro, and when R3is Trp-Pro, then either (i) R6is not Trp or (ii) R7is dCys.

35. The pharmaceutical composition of any one of claims 1 -27 and 34, wherein the non-naturally occurring melanocortin analog comprises a sequence of Formula (IB), wherein:X1is absent or dVal;R1is selected from Nle, dArg, and dPro;R2is selected from the group consisting of Asp, Lys, Cys, and dCys;R3is absent or selected from the group consisting of His, Pro, dAla, Trp-Arg, dLeu, dVal, dPhe, Bip, dBip, dTyr, Trp-Pro, Cpe, Che, Phe-Pro, dHis-Pro, dPro, Hyp, His-Arg, Pro-Arg, Arg-Pro, Acpc, Glu-His, Trp-dLeu, Trp-dVal, dlle, dTrp, and dGIn;R4is selected from the group consisting of dNal(2’), Bip, dBip, dPhe, p(F)dPhe, p(CI)dPhe, p(l)dPhe, and p(Br)dPhe;R5is Arg or Pro;R6is absent or is selected from the group consisting of Trp, Trp-Pro, dNal(1 ’), Phe, dPhe, and Tic;R7is selected from the group consisting of Lys, Asp, Cys, dCys, and Pen;Y1is dVal or Nle;Y2is absent, dPro, or Nle; and-260-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R2and R7when R2is Asp and R7is Lys, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a disulfide bond between R2and R7, when R2is Cys or dCys and R7is Cys, dCys, or Pen, provided that the non-naturally occurring melanocortin analog does not comprise a sequence selected from the group consisting of:Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-NH2(SEQ ID NO: 29);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Phe-Lys]-dVal-dPro-NH2(SEQ ID NO: 41 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-dPhe-Lys]-dVal-dPro-NH2(SEQ ID NO: 42);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-dNal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 43);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Nal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 48);Ac-Nle-c[Asp-Hyp-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 39);Ac-Nle-c[Asp-Hyp-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 40);Ac-dArg-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 179);Ac-dPro-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 181 );Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 194);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 195);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dVal-dPro-NH2(SEQ ID NO: 197);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 198);Ac-Nle-c[Asp-Pro-dNal(2')-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 199);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 201 );Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 202);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 203);Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 204);Ac-Nle-c[dCys-Pro-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 209);Ac-Nle-c[Asp-His-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 338);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 339);Ac-Nle-c[Asp-dAla-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 340);-261 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Trp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 341 );Ac-Nle-c[Cys-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 342);Ac-Nle-c[dCys-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 343);Ac-Nle-c[Cys-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 344);Ac-Nle-c[dCys-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 217);Ac-Nle-c[Cys-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 218);Ac-Nle-c[Asp-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 219);Ac-Nle-c[Asp-Trp-Arg-dNal(2')-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 345);Ac-Nle-c[Lys-Trp-Arg-dNal(2')-Pro-Asp]-dVal-dPro-NH2(SEQ ID NO: 346);Ac-dVal-dPro-c[Lys-Trp-Arg-dNal(2')-Pro-Asp]-Nle-NH2(SEQ ID NO: 347);Ac-dVal-dPro-c[Asp-Trp-Arg-dNal(2')-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 348);Ac-dVal-dPro-c[Asp-Trp-Arg-dNal(2')-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 349);Ac-dVal-dPro-c[Lys-Trp-Arg-dNal(2')-Pro-Asp]-dVal-dPro-NH2(SEQ ID NO: 350);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 51 );Ac-Nle-c[Cys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 62);Ac-Nle-c[dCys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 63);Ac-Nle-c[dCys-His-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 64);Ac-dArg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 65);Ac-Nle-c[Cys-Pro-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 80);Ac-Nle-c[dCys-Pro-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 81 );Ac-Nle-c[dCys-Pro-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 82);Ac-dArg-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 83);Ac-Nle-c[Asp-Bip-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 85);Ac-Nle-c[Asp-dGln-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 86);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 87);Ac-Nle-c[Asp-Trp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 89);Ac-Nle-c[Asp-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 94);Ac-Nle-c[Asp-His-p(F)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 96);Ac-Nle-c[Asp-Pro-p(F)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 97);Ac-dVal-dPro-c[Lys-Trp-Arg-p(F)dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 100);Ac-dVal-dPro-c[Asp-Trp-Arg-p(F)dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 101 );-262-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 107);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 108);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 109);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 110);Ac-Nle-c[Cys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 111 );Ac-Nle-c[dCys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 112);Ac-Nle-c[dCys-His-p(CI)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 113);Ac-Nle-c[Asp-dGln-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 128);Ac-Nle-c[Asp-dTrp-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 129);Ac-Nle-c[Asp-Bip-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 130);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-NH2(SEQ ID NO: 132);Ac-Nle-c[Asp-Trp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 137);Ac-Nle-c[Asp-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 141 );Ac-Nle-c[Asp-His-p(CI)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 143);Ac-Nle-c[Asp-Pro-p(CI)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 144);Ac-dVal-dPro-c[Lys-Trp-Arg-p(CI)dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 149);Ac-dVal-dPro-c[Asp-Trp-Arg-p(CI)dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 150);Ac-dArg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 351 );Ac-Nle-c[Cys-His-p(Br)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 155);Ac-dArg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 156);Ac-Nle-c[Asp-dBip-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 169);Ac-Nle-c[Asp-Pro-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 170);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 171 );Ac-Nle-c[dCys-His-p(Br)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 352);Ac-Nle-c[Asp-dTyr-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 353);Ac-Nle-c[Asp-His-Arg-p(l)dPhe-Arg-Tic-Lys]-dVal-dPro-NH2(SEQ ID NO: 172);Ac-Nle-c[Asp-Pro-Arg-p(l)dPhe-Arg-Tic-Lys]-dVal-dPro-NH2(SEQ ID NO: 173);Ac-Nle-c[Asp-Pro-p(l)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 174);Ac-Nle-c[Asp-His-p(l)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 175);Ac-Nle-c[Asp-Pro-dBip-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 176);Ac-Nle-c[Lys-His-Arg-dBip-Arg-Tic-Asp]-dVal-dPro-NH2(SEQ ID NO: 177);-263-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Lys-Pro-Arg-dBip-Arg-Tic-Asp]-dVal-dPro-NH2 (SEQ ID NO: 178); Ac-Nle-c[dCys-Pro-dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 223); Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 226);Ac-dArg-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 253);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 4);Ac-Nle-c[dCys-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 259); Ac-Nle-c[Asp-Pro-dPhe-Arg-Phe-Lys]-dVal-dPro-NH2(SEQ ID NO: 261 ); Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 262);Ac-dVal-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 265);Ac-Nle-c[Asp-Pro-dPhe-Pro-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 354);Ac-Nle-c[Cys-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 355);Ac-Nle-c[Asp-dPhe-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 268);Ac-Nle-c[Asp-Hyp-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 287);Ac-Nle-c[Asp-dTyr-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 269);Ac-Nle-c[Asp-dGln-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 270);Ac-Nle-c[Asp-dTrp-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 271 );Ac-Nle-c[Asp-Bip-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 272);Ac-Nle-c[Asp-dBip-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 356);Ac-Nle-c[Asp-dLeu-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 297);Ac-dVal-dPro-c[Lys-Trp-Arg-dPhe-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 303);Ac-dVal-dPro-c[Asp-Trp-Arg-dPhe-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 304); Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 284); Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Pro-Lys]-dVal-dPro-NH2 (SEQ ID NO: 285);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 289);Ac-Nle-c[Cys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2 (SEQ ID NO: 290); Ac-Nle-c[dCys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2 (SEQ ID NO: 291 ); Ac-dArg-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 293);Ac-Arg-c[Asp-dAla-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 357);Ac-Nle-c[Asp-dAla-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 311 ); and Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 314), wherein c represents cyclization via a lactam or disulfide bond.-264-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO36. The pharmaceutical composition of any one of claims 1 -27, 34, and 35, wherein the non-naturally occurring melanocortin analog comprises a sequence of Formula (IB(i)):R1- R2- R3- R4- R5- R6- R7- Y1- Y2( I B (i) ) , wherein:R1is Nle, or dArg;R2is selected from the group consisting of Asp, Lys, Cys, and dCys;R3is absent or selected from the group consisting of His, dAla, dLeu, dVal, dPhe, Bip, dBip, dTyr, Trp-Pro, Cpe, Che, Phe-Pro, dHis-Pro, dPro, Hyp, Acpc, Glu-His, Trp- dLeu, Trp-dVal, dlle, dTrp, and dGIn;R4is selected from the group consisting of dNal(2’), dPhe, p(F)dPhe, p(CI)dPhe, and p(Br)dPhe;R5is Arg or Pro;R6is absent or is selected from the group consisting of Trp, Trp-Pro, dNal(1 ’), Phe, and dPhe;R7is selected from the group consisting of Lys, Asp, Cys, dCys, and Pen;Y1is dVal;Y2is dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R2and R7when R2is Asp and R7is Lys, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a disulfide bond between R2and R7, when R2is Cys or dCys and R7is Cys, dCys, or Pen, provided that: when R4is dNal(2’), then R3is not Hyp, dAla, or Trp-Pro, and when R3is absent, then R2is dCys and R7is Cys, when R4is p(F)dPhe, then R3is dPhe, dBip, dTyr, or dTrp, when R4is p(CI)dPhe, then R3is dPhe, dBip, or dTyr,-265-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO when R4is p(Br)dPhe, then R3is dPhe, Bip, dTrp, dGIn, or His, wherein when R3is His then R7is dCys, when R4is dPhe, then R3is not dPhe, dTyr, dGIn, dTrp, dLeu, Bip, or dBip, wherein when R3is dAla, then R1is dArg, when R3is His, then R5is Pro, when R3is Hyp, then R6is Trp-Pro, and when R3is Trp-Pro, then either (i) R6is not Trp or (ii) R7is dCys.

37. The pharmaceutical composition of any one of claims 1 -27 and 34-36, wherein the non-naturally occurring melanocortin analog comprises a sequence of Formula (IB(i)), wherein:R1is Nle, or dArg;R2is selected from the group consisting of Asp, Lys, Cys, and dCys;R3is absent or selected from the group consisting of His, dAla, dLeu, dVal, dPhe, Bip, dBip, dTyr, Trp-Pro, Cpe, Che, Phe-Pro, dHis-Pro, dPro, Hyp, Acpc, Glu-His, Trp- dLeu, Trp-dVal, dlle, dTrp, and dGIn;R4is selected from the group consisting of dNal(2’), dPhe, p(F)dPhe, p(CI)dPhe, and p(Br)dPhe;R5is Arg or Pro;R6is absent or is selected from the group consisting of Trp, Trp-Pro, dNal(1 ’), Phe, and dPhe;R7is selected from the group consisting of Lys, Asp, Cys, dCys, and Pen;Y1is dVal;Y2is dPro; and the non-naturally occurring melanocortin analog is cyclized through a moiety selected from the group consisting of: a lactam bond between R2and R7when R2is Asp and R7is Lys, a lactam bond between R2and R7, when R2is Lys, R3is Trp-Arg, and R7is Asp, a disulfide bond between R2and R7, when R2is Cys or dCys and R7is Cys, dCys, or Pen, provided that the non-naturally occurring melanocortin analog does not comprise a sequence selected from the group consisting of:-266-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-Hyp-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 39);Ac-Nle-c[Asp-Hyp-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 40);Ac-Nle-c[Asp-His-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 338);Ac-Nle-c[Asp-dAla-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 340);Ac-Nle-c[Asp-Trp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 341 );Ac-Nle-c[Cys-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 342);Ac-Nle-c[dCys-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 343);Ac-Nle-c[Cys-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 344);Ac-Nle-c[dCys-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 217);Ac-Nle-c[Cys-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 218);Ac-Nle-c[Asp-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 219);Ac-Nle-c[Cys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 62);Ac-Nle-c[dCys-His-p(F)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 63);Ac-Nle-c[dCys-His-p(F)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 64);Ac-dArg-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 65);Ac-Nle-c[Asp-Bip-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 85);Ac-Nle-c[Asp-dGln-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 86);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 87);Ac-Nle-c[Asp-Trp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 89);Ac-Nle-c[Asp-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 94);Ac-Nle-c[Asp-His-p(F)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 96);Ac-Nle-c[Asp-His-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 107);Ac-Nle-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 110);Ac-Nle-c[Cys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 111 );Ac-Nle-c[dCys-His-p(CI)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 112);Ac-Nle-c[dCys-His-p(CI)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 113);Ac-Nle-c[Asp-dGln-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 128);Ac-Nle-c[Asp-dTrp-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 129);Ac-Nle-c[Asp-Bip-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 130);Ac-Nle-c[Asp-Trp-Pro-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 137);Ac-Nle-c[Asp-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 141 );-267-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Asp-His-p(CI)dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 143);Ac-dArg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 351 );Ac-Nle-c[Cys-His-p(Br)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 155);Ac-dArg-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 156);Ac-Nle-c[Asp-dBip-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 169);Ac-Nle-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 171 );Ac-Nle-c[dCys-His-p(Br)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 352);Ac-Nle-c[Asp-dTyr-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 353);Ac-Nle-c[Asp-dPhe-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 268);Ac-Nle-c[Asp-Hyp-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 287);Ac-Nle-c[Asp-dTyr-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 269);Ac-Nle-c[Asp-dGln-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 270);Ac-Nle-c[Asp-dTrp-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 271 );Ac-Nle-c[Asp-Bip-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 272);Ac-Nle-c[Asp-dBip-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 356);Ac-Nle-c[Asp-dLeu-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 297);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 284);Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 285);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 289);Ac-Nle-c[Cys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 290);Ac-Nle-c[dCys-Trp-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 291 );Ac-dArg-c[Asp-Trp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 293);Ac-Arg-c[Asp-dAla-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 357);Ac-Nle-c[Asp-dAla-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 311 ); and Ac-Nle-c[Asp-His-dPhe-Arg-Trp-Lys]-dVal-dPro-OH (SEQ ID NO: 314), wherein c represents cyclization via a lactam or disulfide bond.

38. The pharmaceutical composition of any one of claims 1 -37, wherein the sequence of any one of Formulae (l)-(IB(i)) is cyclized through a disulfide bond between R2and R7.-268-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO39. The pharmaceutical composition of any one of claims 1 -38, wherein R4is dNal(2’) or dPhe.

40. The pharmaceutical composition of any one of claims 1 -39, wherein at least one of R3and R5is absent.

41. The pharmaceutical composition of any one of claims 1 -40, wherein the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Cys-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 342);Ac-Nle-c[dCys-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 343);Ac-Nle-c[Cys-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 344);Ac-Nle-c[Pen-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 358);Ac-Nle-c[Pen-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 359);Ac-Nle-c[Pen-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 360);Ac-Nle-c[dPen-dNal(2')-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 361 );Ac-Nle-c[dPen-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 362);Ac-Nle-c[Pen-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 363);Ac-Nle-c[dCys-dNal(2')-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 321 );Ac-c[Cys-Arg-dPhe-Cys]-Trp-dVal-dPro-NH2(SEQ ID NO: 378);Ac-Nle-c[Pen-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 379); andAc-Nle-c[Cys-dPhe-Arg-Trp-Pen]-dVal-dPro-NH2(SEQ ID NO: 337), wherein c represents cyclization through R2and R7via a disulfide bond.

42. The pharmaceutical composition of any one of claims 1 -39, wherein R3is Pro.

43. The pharmaceutical composition of any one of claims 1 -39 and 42, wherein the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:-269-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Nle-c[Cys-Pro-dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 355);Ac-Nle-c[Cys-Pro-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 339);Ac-Nle-c[Pen-Pro-dNal(2')-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 370);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 371 );Ac-dPhe-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 372);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dArg-dVal-dPro-NH2(SEQ ID NO: 373);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dArg-dPro-NH2(SEQ ID NO: 374);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dLys-dPro-NH2(SEQ ID NO: 375);Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-Gly-dPen]-dVal-dPro-NH2(SEQ ID NO: 376); and Ac-Nle-c[dPen-Pro-dNal(2')-Arg-Trp-dPen]-dLys-dVal-dPro-NH2(SEQ ID NO: 377), wherein c represents cyclization through R2and R7via a disulfide bond.

44. The pharmaceutical composition of any one of claims 1 -39, wherein R3is an amino acid other than Pro.

45. The pharmaceutical composition of any one of claims 1 -39 and 44, wherein the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of: Ac-Nle-c[dCys-Trp-Pro-dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 333);Ac-Nle-c[dPen-Ala-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 364);Ac-Nle-c[dPen-Leu-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 365);Ac-Nle-c[dPen-dLeu-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 366);Ac-Nle-c[dPen-dVal-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 367);Ac-Nle-c[dPen-Gly-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 368); and Ac-Nle-c[dPen-Gly-Gly-dNal(2')-Arg-Trp-dPen]-dVal-dPro-NH2(SEQ ID NO: 369), wherein c represents cyclization through R2and R7via a disulfide bond.-270-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO46. The pharmaceutical composition of any one of claims 1 -38, wherein R4is p(Br)dPhe.

47. The pharmaceutical composition of any one of claims 1 -38 and 46, wherein the sequence of any one of Formulae (l)-(IB(i)) is:Ac-Nle-c[dCys-His-p(Br)dPhe-Arg-Trp-Cys]-dVal-dPro-NH2(SEQ ID NO: 352); or Ac-Nle-c[dCys-His-p(Br)dPhe-Arg-Trp-dCys]-dVal-dPro-NH2(SEQ ID NO: 327), wherein c represents cyclization through R2and R7via a disulfide bond.

48. The pharmaceutical composition of any one of claims 1 -37, wherein the sequence of any one of Formulae (l)-(IB(i)) is cyclized through a lactam bond between R2and R7.

49. The pharmaceutical composition of any one of claims 1 -37 and 48, wherein R4is Bip, dBip, or p(l)dPhe.

50. The pharmaceutical composition of any one of claims 1 -37, 48, and 49, wherein R6is Trp or Tic.51 . The pharmaceutical composition of any one of claims 1 -37 and 48-50, wherein the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of: Ac-Nle-c[Asp-Pro-Bip-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 384);Ac-Nle-c[Asp-His-Arg-dBip-Arg-Tic-Lys]-dVal-dPro-NH2 (SEQ ID NO: 380);Ac-Nle-c[Asp-Pro-Arg-dBip-Arg-Tic-Lys]-dVal-dPro-NH2 (SEQ ID NO: 381 );Ac-Nle-c[Asp-Arg-Pro-p(l)dPhe-Arg-Tic-Lys]-dVal-dPro-NH2 (SEQ ID NO: 382); and Ac-Nle-c[Asp-Arg-Pro-dBip-Arg-Tic-Lys]-dVal-dPro-NH2 (SEQ ID NO: 383), wherein c represents cyclization through R2and R7via a lactam bond.-271 -SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO52. The pharmaceutical composition of any one of claims 1 -37 and 48, wherein R4is dPhe.

53. The pharmaceutical composition of any one of claims 1 -37, 48, and 52, wherein R3is a dipeptide.

54. The pharmaceutical composition of any one of claims 1 -37, 48, 52, and 53, wherein the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Asp-Phe-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 385);Ac-Nle-c[Asp-dHis-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 386);Ac-Nle-c[Asp-Pro-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 387);Ac-Nle-c[Asp-Trp-dLeu-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 388);Ac-Nle-c[Asp-Trp-dVal-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 389);Ac-Nle-c[Asp-Trp-Pro-dPhe-His-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 390);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Nal(1')-Lys]-dVal-dPro-NH2(SEQ ID NO: 391 );Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-dNal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 392);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-Phe-Lys]-dVal-dPro-NH2 (SEQ ID NO: 393);Ac-Nle-c[Asp-Trp-Pro-dPhe-Arg-dPhe-Lys]-dVal-dPro-NH2 (SEQ ID NO: 394);Ac-Nle-c[Asp-Pro-His-dPhe-His-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 395); andAc-Nle-c[Glu-Pro-His-dPhe-His-Trp-Orn]-dVal-dPro-NH2(SEQ ID NO: 396), wherein c represents cyclization through R2and R7via a lactam bond.

55. The pharmaceutical composition of any one of claims 1 -37, 48, and 52, wherein R3is Pro.-272-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO56. The pharmaceutical composition of any one of claims 1 -37, 48, 52, and 55, wherein the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-dNle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 397);Ac-dPhe-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 398);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-Arg-NH2 (SEQ ID NO: 399);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dLys-dPro-NH2 (SEQ ID NO: 400);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Lys-Val-Pro-NH2 (SEQ ID NO: 401 );Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-Asp-NH2 (SEQ ID NO: 402);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dThr-dPro-dThr-NH2 (SEQ ID NO: 403);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-p2Val-pPro-NH2 (SEQ ID NO: 404);Ac-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-p3Val-pPro-NH2 (SEQ ID NO: 405);Ac-Nle-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 406); andAc-Nle-Nle-Nle-c[Asp-Pro-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 407), wherein c represents cyclization through R2and R7via a lactam bond.

57. The pharmaceutical composition of any one of claims 1 -37, 48, and 52, wherein R3is an amino acid other than Pro.

58. The pharmaceutical composition of any one of claims 1 -37, 48, 52, and 57, wherein the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Asp-dlle-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 408);Ac-Nle-c[Asp-Hyp-dPhe-Arg-Trp-Pro-Lys]-dVal-dPro-NH2 (SEQ ID NO: 409);Ac-Nle-c[Asp-dVal-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 328);Ac-Nle-c[Asp-dBip-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 356);-273-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-Arg-c[Asp-dAla-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 357);Ac-Nle-c[Asp-Cpe-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 334);Ac-Nle-c[Asp-Che-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 335); andAc-dArg-c[Asp-dAla-dPhe-Arg-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 336), wherein c represents cyclization through R2and R7via a lactam bond.

59. The pharmaceutical composition of any one of claims 1 -37, 48, and 52, wherein R5is an amino acid other than Arg or R6is an amino acid other than Trp.

60. The pharmaceutical composition of any one of claims 1 -37, 48, 52, and 59, wherein the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Asp-Pro-dPhe-Arg-dNal(1 ')-Lys]-dVal-dPro-NH2(SEQ ID NO: 260);Ac-Nle-c[Asp-Pro-dPhe-Pro-Trp-Lys]-dVal-dPro-NH2 (SEQ ID NO: 354); andAc-Nle-c[Asp-His-dPhe-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 316), wherein c represents cyclization through R2and R7via a lactam bond.61 . The pharmaceutical composition of any one of claims 1 -37 and 48, wherein R4is selected from p(Br)dPhe, p(CI)dPhe, and p(F)dPhe.

62. The pharmaceutical composition of any one of claims 1 -37, 48, and 61 , wherein R3is Pro or His.

63. The pharmaceutical composition of any one of claims 1 -37, 48, 61 , and 62, wherein the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dTle-dTle-dVal-NH2(SEQ ID NO: 410);Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Trp-Lys]-dVal-dVal-dVal-dPro-NH2(SEQ ID NO: 411 );-274-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WOAc-dArg-c[Asp-His-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 351 );Ac-Nle-c[Asp-Pro-p(F)dPhe-Arg-Nal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 412);Ac-His-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 413); and Ac-dHis-c[Asp-His-p(Br)dPhe-Arg-Trp-Lys]-dTle-dPro-NH2(SEQ ID NO: 414), wherein c represents cyclization through R2and R7via a lactam bond.

64. The pharmaceutical composition of any one of claims 1 -37, 48, and 61 , wherein R3is an amino acid other than Pro or His.

65. The pharmaceutical composition of any one of claims 1 -37, 48, 61 , and 64, wherein the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Asp-dTyr-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 353);Ac-Nle-c[Asp-dPhe-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 324);Ac-Nle-c[Asp-dBip-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 325);Ac-Nle-c[Asp-dTyr-p(CI)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 326);Ac-Nle-c[Asp-dPhe-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 329);Ac-Nle-c[Asp-dPhe-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 330);Ac-Nle-c[Asp-dBip-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 331 );Ac-Nle-c[Asp-dTyr-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 332);Ac-Nle-c[Asp-dTrp-p(F)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 415);Ac-Nle-c[Asp-Bip-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 416);Ac-Nle-c[Asp-dGln-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 417); and Ac-Nle-c[Asp-dTrp-p(Br)dPhe-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 418), wherein c represents cyclization through R2and R7via a lactam bond.-275-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO66. The pharmaceutical composition of any one of claims 1 -37 and 48, wherein R4is dNal(2’).

67. The pharmaceutical composition of any one of claims 1 -37, 48, and 66, wherein R3is Pro.

68. The pharmaceutical composition of any one of claims 1 -37, 48, 66, and 67, wherein the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-Nle-Nle-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 419);Ac-Nle-c[Asp-Pro-dNal(2')-Arg-Trp-dOrn]-dVal-dPro-NH2(SEQ ID NO: 420); and c[CO-cis-CH=CH-CO-Pro-dNal(2’)-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 421 ), wherein c represents cyclization through R2and R7via a lactam bond.

69. The pharmaceutical composition of any one of claims 1 -37, 48, 66, and 67, wherein R5is an amino acid other than Arg.

70. The pharmaceutical composition of any one of claims 1 -37, 48, 66, 67, and 69, wherein the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Asp-Pro-dNal(2')-dLys-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 422);Ac-Nle-c[Asp-Pro-dNal(2')-dArg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 423);Ac-Nle-c[Asp-Pro-dNal(2')-dOrn-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 424);Ac-Nle-c[Asp-Pro-dNal(2')-Glu-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 425);Ac-Nle-c[Asp-Pro-dNal(2')-dAsp-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 426); andAc-Nle-c[Asp-Pro-dNal(2')-dGlu-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 427), wherein c represents cyclization through R2and R7via a lactam bond.-276-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO71. The pharmaceutical composition of any one of claims 1 -37, 48, and 66, wherein R3is an amino acid other than Pro.

72. The pharmaceutical composition of any one of claims 1 -37, 48, 66, and 71 , wherein the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Asp-His-dNal(2')-Arg-Trp-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 338);Ac-Nle-c[Asp-dAla-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 340);Ac-Nle-c[Asp-dMet-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 428);Ac-Nle-c[Asp-Gly-Gly-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 429);Ac-Nle-c[Asp-p-Ala-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 430);Ac-Nle-c[Asp-Mamb-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 431 );Ac-Nle-c[Asp-Cpe-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 432);Ac-Nle-c[Asp-Che-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 433);Ac-Arg-c[Asp-dAla-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 434);Ac-Nle-c[Asp-His-dNal(2')-Pro-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 317);Ac-dArg-c[Asp-dAla-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 318);Ac-Nle-c[Asp-dLeu-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 322);Ac-Nle-c[Asp-dVal-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 323);Ac-Nle-c[Asp-dPro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 435);Ac-Nle-c[Asp-dlle-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 436);Ac-Nle-c[Asp-dTrp-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 437); andAc-Nle-c[Asp-Acpc-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 438), wherein c represents cyclization through R2and R7via a lactam bond.-277-SMRH:4899-8459-8892.5Docket No.: 183B-412994-WO73. The pharmaceutical composition of any one of claims 1 -37, 48, and 66, wherein R3is dipeptide.

74. The pharmaceutical composition of any one of claims 1 -37, 48, 66, and 73, wherein the sequence of any one of Formulae (l)-(IB(i)) is selected from the group consisting of:Ac-Nle-c[Asp-Glu-His-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 439);Ac-Nle-c[Asp-Pro-Glu-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 440);Ac-Nle-c[Asp-Pro-Glu-dNal(2')-Arg-Trp-Gly-Lys]-dVal-dPro-NH2(SEQ ID NO: 441 );Ac-Nle-c[Asp-Trp-Pro-dNal(2')-Arg-Trp-Lys]-dVal-dPro-NH2(SEQ ID NO: 341 );Ac-Nle-c[Asp-Trp-Arg-dNal(2')-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 345);Ac-Nle-c[Asp-Pro-Trp-Arg-dNal(2')-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 442);Ac-Nle-c[Asp-Pro-Trp-Arg-dNal(2')-Lys]-dVal-dPro-NH2(SEQ ID NO: 443);Ac-Nle-c[Lys-Trp-Arg-dNal(2')-Pro-Asp]-dVal-dPro-NH2(SEQ ID NO: 346);Ac-dVal-dPro-c[Lys-Trp-Arg-dNal(2')-Pro-Asp]-Nle-NH2(SEQ ID NO: 347);Ac-dVal-dPro-c[Asp-Trp-Arg-dNal(2')-Pro-Lys]-Nle-Nle-NH2(SEQ ID NO: 348);Ac-dVal-dPro-c[Asp-Trp-Arg-dNal(2')-Pro-Lys]-dVal-dPro-NH2(SEQ ID NO: 349);Ac-dVal-dPro-c[Lys-Trp-Arg-dNal(2')-Pro-Asp]-dVal-dPro-NH2(SEQ ID NO: 350);Ac-dVal-dPro-c[Asp-Trp-Arg-dNal(2')-Pro-Lys]-Nle-NH2(SEQ ID NO: 319); andAc-dVal-dPro-c[Lys-Trp-Arg-dNal(2')-Pro-Asp]-Nle-Nle-NH2(SEQ ID NO: 320), wherein c represents cyclization through R1or R2and R7via a lactam bond.-278-SMRH:4899-8459-8892.5

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