Novel enhanced ICAD stent and delivery systems

Abstract

An ICAD stent and delivery system features loading between two catheters to support tracking to its target location of a system with radiopaque markers indicating regions of high radial force under flouroscopy, inter alia – plaque supporting radial force variation allows both an implantable and retrievable system. Different density segments or transverse zones of the stent allow for unique performance in situ.

Description

NOVEL ENHANCED ICAD STENT AND DELIVERY SYSTEMSCross-Reference To Related Applications

[0001] The present application claims priority to U. S. Patent Application No.63 / 718,805, filed November 11, 2024, the contents of which are incorporated herein by reference in their entirety.Field of the Invention

[0002] The field of the invention is systems, devices, and methods of treatment for Intracranial Atherschl erotic Disease (ICAD). These inventions apply in the context of any treatment using stenting, or secondary to another procedure ( for example as rescue therapy).Background

[0003] Endovascular therapy and related minimally invasive treatments for stenotic disease and stroke requires new tools, and different uses of those already developed to maintain clinical relevancy. The background description includes information that may be useful in understanding the present invention. It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art.

[0004] During therapy, for example, with antegrade blood flow, an engaged emboli can become dislodged from the mechanical device. Blood flow has a water-hammer effect on the emboli which can break pieces of the emboli off or entirely dislodge the emboli from the capturing device. Devices used for therapy must have the ability to manage existing plaque deposits in tandem with restoration of blood flow.

[0005] In most cases, the dislodged emboli or fragments thereof can either reocclude the original vessel or occlude a new vessel or territory. Plaque build-up, as shown in Fig. 2 is why ICAD stents and delivery systems must be alternately configured.

[0006] Thus, there is still a need for improved devices and methods of ICAD stenting delivery systems and devices, and especially neurovascular ICAD stenting devices.Summary of The Invention

[0007] The present inventive subject matter is drawn to compositions, devices, and methods of use and manufacture of ICAD stenting devices and delivery systemsthat may be comprised of mechanical devices with 2 or more variable radial force zones and more than 2 diameters. Variable radial force components include at least a variable radial force component for supporting plaque housed within a two catheter loading system to support tracking to a target location

[0008] Likewise, by using two catheter supporting of tracking variable stiffness may be used to support the plaque and allow emplacement of the instant system,

[0009] Also the distal tip can be configured with closed end or porous end. The distal tip can be closed with a laser cut configuration and / or covered with PTFE, or a braid of polymer or metal.

[0010] Various objects, features, aspects and advantages of the inventive subject matter will become more apparent from the following detailed description of preferred embodiments, along with the accompanying drawing figures in which like numerals represent like components.Brief Description of The Drawing

[0011] Fig. 1 is a plan and partial perspective view of an exemplary ICAD stent and delivery device according to the inventive subject matter, namely an exaggerated cartooned schematic showing different regions of variable strength;

[0012] Fig 2 shows an ICAD device according to the instant inventions;

[0013] Fig. 3 is a side view of plaque-laiden vessel, typical of situs for use of device of Fig. 1 and 3-8;

[0014] Fig. 3 is a perspective view of another exemplary stenting device according to the inventive subject matter, showing variable cell structures which may be used;

[0015] Fig. 4 is a side view of an exemplary stent embodying the device of Fig. 1;

[0016] Fig. 5 is another view of an exemplary stenting device according to the inventive subject matter, likewise showing radiopaque markers;

[0017] Fig. 6 is an electron micrograph (top view) of an exemplary stenting device according to the inventive subject matter;

[0018] Fig. 7 is an electron micrograph (top view) of an exemplary delivery system for an ICAD stenting device according to the inventive subject matter; and,

[0019] Fig. 8 is exemplary delivery system for an ICAD stenting device according to the inventive subject matter effective for at least one of temporary deployment and permanent emplacement according to the inventive subject matter.Detailed Description

[0020] The inventors have discovered that IC / XD stenting devices with improved implantation characteristics, and especially with improved flow characteristics can be prepared by the present invention.

[0021] The following discussion provides many example embodiments of the inventive subject matter. Although each embodiment represents a single combination of inventive elements, the inventive subject matter is considered to include all possible combinations of the disclosed elements. Thus if one embodiment comprises elements A, B, and C, and a second embodiment comprises elements B and D, then the inventive subject matter is also considered to include other remaining combinations of A, B, C, or D, even if not explicitly disclosed. As used in the description herein and throughout the claims that follow, the meaning of "a, an," and "the" includes plural reference unless the context clearly dictates otherwise. Also, as used in the description herein, the meaning of "in" includes "in" and "on" unless the context clearly dictates otherwise.

[0022] Moreover, as used herein, and unless the context dictates otherwise, the term "coupled to" is intended to include both direct coupling (in which two elements that are coupled to each other contact each other) and indirect coupling (in which at least one additional element is located between the two elements). Therefore, the terms "coupled to" and "coupled with" are used synonymously.

[0023] In one especially preferred aspect of the inventive subject matter the combination of zones and segments allows for delivery of therapy, as known to those skilled in the art.

[0024] Fig. 1 provides an exemplary illustration of the inventive subject matter, depicting an ICAD system and devices in situ;

[0025] Fig. 2 through fig. 8 show a typical location for the present invetnions. less any exemplary views of the novel enhanced ICAD stenting system with a plurality of zones or segments with having specialized center symmetry, and then the stents segments themselves.

[0026] Those skilled in the art know that each section has a functional point to make the stent stronger in the middle and it can be done multiple ways, as shown and claimed.

[0027] Fig. 4 shows a novel enhanced ICAD stenting system, further comprised of at least four zones disposed in a least a co-axial stenting assembly, in combination - Fig 5 shows at least a center segment, characterized in that relative to the other segments it has high radial force and remains stiff to open up the artery that plaque buildup is being addressed in.

[0028] Fig. 6 shows at least a transition segment, with sufficient radial force and some flexibility for smooth transition.

[0029] Fig. 7 is an exemplary geometry' of at least a Flexible segment, having lower radial force with high flexibility for conforming with tortuous vessels.

[0030] Fig. 8 the novel enhanced ICAD stenting system of claim 9, further comprised, in combination, of at least an anchor segment, with high radial force to provide stability and set the stent in place after deployment.

[0031] Likewise, other therapies are deliverable though the ICAD system for example coils, ad described herein and inherent to Artisans. Accordingly embraced as deliverable of the present inventions and patentable per se.

[0032] It should be apparent to those skilled in the art that many more modifications besides those already described are possible without departing from the inventive concepts herein. The inventive subject matter, therefore, is not to be restricted except in the spirit of the appended claims. Moreover, in interpreting both the specification and the claims, all terms should be interpreted in the broadest possible manner consistent with the context. In particular, the terms “^comprises” and "comprising" should be interpreted as referring to elements, components, or steps in a non-exclusive manner, indicating that the referenced elements, components, or steps may be present, or utilized, or combined with other elements, components, or steps that are not expressly referenced. Where the specification claims refers to at least one of something selected from the group consisting of A, B, C, and N, the text should be interpreted as requiring only one element from the group, not A plus N, or B plus N, etc.

Claims

CLAIMSWhat is claimed is:

1. An ICAD stent and delivery device system, which is comprised of, in combination:at least a variable radial force component for supporting plaque housed within a two catheter loading system to support tracking to a target location.

2. The ICAD stent and delivery device system of claim 1, wherein radiopaque markers are used to indicate regions of higher radial force under imagery.

3. The ICAD stent and delivery device system of claim 2, further comprising:being at least one of deployed temporarily and permanently implanted.

4. ICAD stent and delivery device system disclosed herein wherein the body portion comprises at least a metal.

5. IC / AD stent and delivery device system wherein the body portion has a spiral geometry comprised of a plurality of different density sections.

6. Novel enhanced ICAD stenting system with a plurality of zones or segments with having specialized center symmetry,7. Novel enhanced ICAD stenting system, further comprised of at least four zones disposed in a least a co-axial stenting assembly, in combination.

8. Novel enhanced ICAD stenting system of claim 7, further comprised, in combination, of:at least a center segment, characterized in that relative to the other segments it has high radial force and remains stiff to open up the artery that plaque buildup is being addressed in.

9. Novel enhanced ICAD stenting system of claim 8, further comprised, in combination, of:at least a transition segment, with sufficient radial force and some flexibility for smooth transition.

10. Novel enhanced ICAD stenting system of claim 9, further comprised, in combination, of:at least a Flexible segment, having lower radial force with high flexibility for conforming with tortuous vessels.

11. Novel enhanced ICAD stenting system of claim 9, further comprised, in combination, of at least an anchor segment, with high radial force to provide stability and set the stent in place after deployment:

12. Novel enhanced IC / XD stenting system of claim 11, further comprised, in combination, of at least a variable radial force component for supporting plaque housed within a two catheter delivery system.

13. Novel enhanced ICAD stenting system of claim 12, further comprised, in combination, of: radiopaque markers are used to indicate regions of higher radial force under imagery.

14. A coil member for aneurysm treatment having a body portion having a surface, wherein the body portion is configured to have an electropositive surface under physiological conditions when the device is implanted into an aneurysm or vesicle; and wherein the surface is sufficiently electropositive such that the surface ionically binds a blood component in an amount effective to promote coagulation of blood in the aneurysm or vesicle, or to bind to a tissue component in an amount effective to increase adhesion of the device as compared to a device without electropositive surface.

15. Coil member for aneurysm treatment comprised of claim 14 being a framing coil and filling coil combination, wherein the gross morphology of the resting coil is polyhedral but not tetrahedral.

16. Coil member of claim 15, having filing and framing components which are neither parallel nor coincident when arrayed for deployment.

17. Coil member delivery system of claim 16, further comprised of at least a HOOP; UV ADHESIVE; WARNING MARK; INTRODUCER; PUSHER SUBASSEMBLY and IMPLANT SUBASSEMBLY.

18. Coil member delivery system of claim 17, being electrolytically detachable.

19. An ICAD system modified to deliver the coil of claim 18.

20. The ICAD system of claim 19, being further comprised of:at least a Flexible segment, having lower radial force with high flexibility for conforming with tortuous vessels;at least an anchor segment, with high radial force to provide stability and set a stent in place after deploymand include f at least a variable radial force component for supporting plaque housed within a two catheter delivery system.

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