Ablation condition determination apparatus and method, and computer-readable storage medium
By detecting the first impedance information among multiple ablation electrodes within the ablation area and analyzing it using the ablation status judgment module, the problem of accurately and in real-time grasping the ablation status is solved, thus achieving the safety and effectiveness of ablation.
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- SHANGHAI GOLDEN LEAF MED TEC CO LTD
- Filing Date
- 2025-11-24
- Publication Date
- 2026-06-04
AI Technical Summary
Existing technologies cannot accurately monitor ablation in real time, leading to over- or under-ablation, which affects treatment efficacy and safety.
By detecting the first impedance information among multiple ablation electrodes within the ablation area and analyzing it using the ablation status judgment module, the ablation status can be judged accurately in real time.
It enables real-time and accurate monitoring of the ablation process, avoiding damage to non-target tissues and poor ablation results caused by over-ablation.
Smart Images
Figure CN2025137199_04062026_PF_FP_ABST
Abstract
Description
Device, method and computer-readable storage medium for determining ablation status
[0001] Cross-reference to related applications
[0002] This application claims priority to Chinese Patent Application No. 202411706408.0, filed on November 26, 2024, entitled "Ablation Assessment Apparatus, Method and Computer-Readable Storage Medium", the entire contents of which are incorporated herein by reference. Technical Field
[0003] This application relates to the field of medical devices, and more specifically, to an ablation status assessment device, method, and computer-readable storage medium. Background Technology
[0004] In the field of ablation, accurately monitoring the ablation process is crucial. It not only ensures surgical precision, allowing ablation to target the desired tissue precisely, but also provides real-time feedback to help doctors dynamically adjust the procedure, avoiding over- or under-ablation. Furthermore, a comprehensive understanding of the ablation process helps prevent complications, such as damage to adjacent healthy tissue, improving the safety and effectiveness of treatment, and ultimately providing patients with personalized, optimal treatment plans.
[0005] Currently, the understanding of the ablation status comes from collecting the change in circuit impedance between the neutral electrode applied to the body surface and the ablation electrode in the target ablation area. The ablation status is then determined by the impedance change.
[0006] However, there is a certain distance between the ablation electrode located in the target ablation area and the neutral electrode on the body surface, and the distance may vary. On the other hand, different target ablation objects may have tissue and anatomical differences. This may result in large differences in impedance values depending on the electrode placement or the patient, making it difficult to accurately and in real time monitor the ablation status. Summary of the Invention
[0007] The purpose of this application is to provide an ablation status assessment device, method, and computer-readable storage medium. A first impedance detection circuit detects the first impedance information between the target ablation electrode pair, and an ablation status assessment module analyzes this first impedance information, thereby achieving high real-time performance and accuracy in assessing the ablation status. Real-time and accurate monitoring of the ablation status not only greatly avoids damage to non-target tissues caused by over-ablation but also prevents suboptimal ablation effects due to insufficient ablation time.
[0008] In a first aspect, embodiments of this application provide an ablation status determination device, which is applied to an ablation device including multiple ablation electrodes. The ablation status determination device includes: a first impedance detection circuit and an ablation status determination module; the multiple ablation electrodes are configured to contact the ablated tissue wall and release ablation energy during the ablation process; the first impedance detection circuit is connected to the multiple ablation electrodes and configured to detect first impedance information between target ablation electrode pairs; the ablation status determination module is connected to the first impedance detection circuit and configured to acquire the first impedance information and determine the current ablation status based on the first impedance information.
[0009] In the above implementation process, the ablation status judgment device provided in this application embodiment detects the first impedance information between the target ablation electrode pairs through the first impedance detection circuit, and analyzes the first impedance information through the ablation status judgment module to obtain the current ablation status. Therefore, the ablation status judgment device provided in this application embodiment has high real-time performance and accuracy in judging the ablation status because the first impedance detection circuit detects the first impedance information between each pair of ablation electrodes within the ablation area. Real-time and accurate grasp of the ablation status can not only greatly avoid damage to non-target tissues caused by over-ablation, but also avoid poor ablation effects caused by insufficient ablation time.
[0010] Optionally, in this embodiment, the first impedance detection circuit includes a first impedance measurement unit and a plurality of first impedance detection switches; each first impedance detection switch is connected to the first impedance measurement unit and an ablation electrode; the first impedance detection switch is configured to form a first impedance detection path for the target ablation electrode pair when the corresponding first impedance detection switch of the target ablation electrode pair is closed; the first impedance measurement unit is configured to measure the first impedance information between the target ablation electrode pairs.
[0011] In the above implementation process, the first impedance detection circuit and multiple first impedance detection switches in the ablation status judgment device provided in this application embodiment are connected to realize impedance measurement between pairs of ablation electrodes. That is to say, the ablation status judgment device provided in this application embodiment can quickly and flexibly measure the first impedance information between different electrode pairs, and can realize the real-time monitoring of the ablation status of each ablation point in the target ablation area.
[0012] Optionally, in this embodiment, the first impedance detection switch includes a first terminal switch and a second terminal switch; the first terminal switch is connected to the first terminal of the first impedance measurement unit and the target ablation electrode; the second terminal switch is connected to the second terminal of the first impedance measurement unit and the target ablation electrode; the first terminal switch and the second terminal switch are configured to form a first impedance detection path including the first target ablation electrode and the second target ablation electrode when the first terminal switch corresponding to the first target ablation electrode and the second terminal switch corresponding to the second target electrode are closed, or when the second terminal switch corresponding to the first target ablation electrode and the first terminal switch corresponding to the second target electrode are closed.
[0013] In the above implementation process, this application provides an example of a first impedance detection circuit, providing a first scheme for detecting the first impedance information between pairs of ablation electrodes. Each electrode is connected to both ends of the first impedance detection unit via a switch. By switching the switches on and off, different combinations of ablation electrodes are achieved, and the first impedance between different pairs of ablation electrodes is measured. By measuring the first impedance information between the target ablation electrode and other ablation electrodes, the ablation status of the target ablation point corresponding to the target ablation electrode can be determined. This not only overcomes the inaccuracy and individual differences in impedance acquisition from the ablation electrode to the body surface electrode in traditional methods, but also accurately and in real time obtains the ablation status of the target ablation area, ensuring the safety and effectiveness of smile surgery.
[0014] Optionally, in this embodiment of the application, the ablation status determination device further includes a plurality of ablation switches and a wall-attachment detection circuit having a plurality of wall-attachment detection switches; each ablation switch is connected to the wall-attachment detection circuit and an ablation electrode, and the ablation switch is configured to form a wall-attachment detection loop including the ablation electrode and the wall-attachment detection circuit when the ablation switch and the corresponding wall-attachment detection switch are closed.
[0015] Optionally, in this embodiment, the wall adhesion detection circuit further includes a neutral electrode and a second impedance measurement unit; the neutral electrode is disposed on the surface of the target ablation object; the first end of the second impedance measurement unit is connected to multiple ablation electrodes through multiple wall adhesion detection switches; the second end of the second impedance measurement unit is connected to the neutral electrode; the second impedance measurement unit is configured to measure the second impedance information between the neutral electrode and the ablation electrode corresponding to the wall adhesion detection switch when the wall adhesion detection switch is closed and the corresponding ablation switch is closed.
[0016] In the above implementation process, the ablation status judgment device provided in this application embodiment is provided with a wall adhesion detection circuit. The wall adhesion detection circuit can measure the second impedance information between the target ablation electrode and the neutral electrode disposed on the surface of the ablation object. Based on the second impedance information, the wall adhesion status of the target ablation electrode can be determined, thereby enabling effective ablation and ensuring that the first impedance information between the two ablation electrodes is available, which is beneficial to accurately grasp the ablation status of the target ablation area.
[0017] Optionally, in this embodiment, the first impedance detection switch includes a first switch and a second switch; the first switch is connected to a first terminal of the first impedance measurement unit and a first target ablation electrode; the second switch is connected to a second terminal of the first impedance measurement unit and a second target ablation electrode; the first switch and the second switch are configured to form a first impedance measurement path including a first target ablation electrode, a second target ablation electrode and a first impedance measurement unit when the first switch and the second switch are closed.
[0018] In the above implementation process, the structure of the second example diagram of the first impedance detection circuit provided in this application replaces one ablation point corresponding to one ablation electrode with one ablation point corresponding to two ablation electrodes; thus, the implementation architecture for measuring the impedance between two points in the target ablation area to understand the ablation situation is simpler, and the ablation situation can be understood efficiently and accurately with a simpler structure.
[0019] Optionally, in this embodiment of the application, the ablation status determination device further includes a temperature detection module; the temperature detection module is connected to the ablation status determination module and configured to detect the temperature information of the target ablation area; the ablation status determination module is further configured to determine the current ablation status based on the first impedance information and the temperature information.
[0020] In the above implementation process, the ablation status judgment device provided in this application embodiment adds a temperature detection module to monitor the real-time ablation temperature at a certain depth of the target ablation area. This can be used in conjunction with the first impedance information to provide a more comprehensive judgment of the ablation status. This helps to more accurately monitor and control the ablation process, avoid tissue damage caused by overheating or insufficient ablation due to excessively low temperatures, and further improve the safety and efficacy of the surgery.
[0021] Optionally, in this embodiment of the application, the ablation status judgment module, in the process of judging the current ablation status based on the first impedance information and temperature information, is specifically used to: judge whether the decrease in the first impedance information reaches the impedance decrease threshold, and / or judge whether the temperature information reaches the temperature threshold and is maintained for a preset time; if the decrease in the first impedance information reaches the impedance decrease threshold, and / or whether the temperature information reaches the temperature threshold and is maintained for a preset time, then it is determined that the ablation endpoint has been reached.
[0022] In the above implementation process, the ablation status judgment module of the ablation status judgment device provided in this application embodiment can directly determine that the ablation endpoint has been reached by the decrease of the first impedance information and / or whether the temperature information of a certain ablation depth has reached the temperature threshold and maintained for a certain period of time. Otherwise, ablation continues. Therefore, the ablation status judgment device provided in this application embodiment can achieve efficient and accurate control of the ablation status by analyzing the collected data through the ablation status judgment module.
[0023] Secondly, embodiments of this application provide a method for determining the ablation endpoint. This method is applied to an ablation status determination device, which includes a first impedance detection circuit and an ablation status determination module. The ablation endpoint determination method includes: obtaining first impedance information between the target ablation electrode and other ablation electrodes by the first impedance detection circuit; and determining, based on the impedance information, whether the target ablation point corresponding to the target electrode has reached the ablation endpoint by the ablation status determination circuit. The target ablation electrode and other ablation electrodes are attached to the target ablation tissue wall and used to release ablation energy.
[0024] Optionally, in this embodiment of the application, the ablation status judgment module further includes a wall adhesion detection circuit; before obtaining the impedance information between the target ablation electrode and other ablation electrodes, the ablation endpoint judgment method further includes: the wall adhesion detection circuit detects the adhesion of the ablation electrodes, including the target ablation electrode and other ablation electrodes, to the wall of the ablated tissue.
[0025] Optionally, in this embodiment of the application, obtaining the first impedance information between the target ablation electrode and other ablation electrodes includes: measuring the impedance information between the target ablation electrode and another ablation electrode in a time-division manner until the measurement of the impedance information between the target ablation electrode and all other ablation electrodes is completed; and controlling the ablation electrodes that have not undergone impedance information measurement to output ablation energy.
[0026] In the above implementation process, the ablation endpoint determination method provided in this application embodiment is based on the volume impedance value change along the artery length collected by the ablation endpoint determination device, which can better reflect the actual ablation effect at the ablation point. At the same time, an omnidirectional ultrasound transducer can be set at the center of the catheter to detect the actual ablation temperature within a certain depth in real time, which can intuitively and directly assess the degree of nerve damage achieved by ablation and accurately and timely determine the ablation endpoint.
[0027] Thirdly, embodiments of this application provide an electronic device, which includes a memory and a processor. The memory stores program instructions, and when the processor reads and runs the program instructions, it executes the steps in any of the above implementation methods.
[0028] Fourthly, embodiments of this application also provide a computer-readable storage medium storing computer program instructions, which, when read and executed by a processor, perform the steps in any of the above implementations. Attached Figure Description
[0029] To more clearly illustrate the technical solutions of the embodiments of this application, the accompanying drawings used in the embodiments of this application will be briefly introduced below. It should be understood that the following drawings only show some embodiments of this application and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.
[0030] Figure 1 is a first schematic diagram of the architecture of the ablation determination device provided in an embodiment of this application;
[0031] Figure 2 is a schematic diagram of the first impedance detection circuit provided in an embodiment of this application;
[0032] Figure 3 is a structural example diagram of the first impedance measurement unit provided in an embodiment of this application;
[0033] Figure 4 is a first example diagram of the first impedance detection circuit of the ablation condition judgment device provided in the embodiment of this application;
[0034] Figure 5 is an example diagram of adding a wall-mounted detection circuit to the first example diagram of the first impedance detection circuit provided in the embodiments of this application;
[0035] Figure 6 is a second example diagram of the first impedance detection circuit of the ablation condition judgment device provided in the embodiment of this application;
[0036] Figure 7 is a second schematic diagram of the architecture of the ablation determination device provided in the embodiment of this application;
[0037] Figure 8 is an example diagram of the first setting position of the temperature detection module provided in an embodiment of this application;
[0038] Figure 9 is an example diagram of the second setting position of the temperature detection module provided in an embodiment of this application;
[0039] Figure 10 is a comparison of ultrasound images (a) of the target ablation tissue before ablation and ultrasound images (b) after ablation provided in the embodiments of this application;
[0040] Figure 11 is an example diagram showing the relationship between grayscale value and temperature change provided in an embodiment of this application;
[0041] Figure 12 is a flowchart of the ablation endpoint determination method provided in an embodiment of this application;
[0042] Figure 13 is a schematic diagram of the structure of the electronic device provided in the embodiment of this application.
[0043] Icons: Ablation status judgment device-1000; First impedance detection circuit-100; First impedance measurement unit-110; First impedance detection switch-120; First terminal switch-121; Second terminal switch-122; First switch-123; Second switch-124; Ablation status judgment module-200; Ablation switch-300; Wall adhesion detection circuit-400; Wall adhesion detection switch-410; Neutral electrode-420; Second impedance measurement unit-430; Temperature detection module-500; Electronic equipment-600; Processor-601; Memory-602. Detailed Implementation
[0044] The technical solutions of the embodiments of this application will now be described with reference to the accompanying drawings. For example, the flowcharts and block diagrams in the drawings illustrate the architecture, functions, and operations of possible implementations of systems, methods, and computer program products according to various embodiments of the present invention. In this regard, each block in the flowchart or block diagram may represent a module, program segment, or part of code, which contains one or more executable instructions for implementing a specified logical function. It should also be noted that in some alternative implementations, the functions marked in the blocks may occur in a different order than those marked in the drawings. For example, two consecutive blocks may actually be executed substantially in parallel, and they may sometimes be executed in reverse order, depending on the functions involved. It should also be noted that each block in the block diagram and / or flowchart, and combinations of blocks in the block diagram and / or flowchart, can be implemented using a dedicated hardware-based system that performs the specified function or action, or can be implemented using a combination of dedicated hardware and computer instructions. In addition, the functional modules in the various embodiments of the present invention may be integrated together to form an independent part, or each module may exist separately, or two or more modules may be integrated to form an independent part.
[0045] Ablation is a medical technique that uses physical or chemical means to destroy or remove body tissue. Ablation techniques can be used to treat abnormal tissues, such as tumors, conductive tissues with abnormal heart rhythms, or other lesions. Currently, there are various ablation methods, such as radiofrequency ablation, which uses high-frequency current to heat and destroy target tissue, often used to treat arrhythmias and renal artery ablation (for hypertension); laser ablation, which uses laser energy to destroy diseased tissue, often used in dermatological and ophthalmic surgeries; cryoablation, which uses extremely low temperatures (usually liquid nitrogen or other coolants) to freeze and kill diseased tissue, often used in tumor treatment; and chemical ablation, which uses the injection of chemical drugs to dissolve or destroy diseased tissue, and can be used for some special types of lesions (such as liver cancer).
[0046] During ablation, accurately monitoring the ablation process is crucial. This not only ensures surgical precision, allowing the ablation to accurately target the desired tissue, but also provides real-time feedback to help doctors dynamically adjust the procedure, avoiding over- or under-ablation. Furthermore, a comprehensive understanding of the ablation process helps prevent complications, such as damage to adjacent healthy tissue, improving the safety and effectiveness of treatment, and ultimately providing patients with personalized, optimal treatment plans.
[0047] Currently, the ablation status is determined by measuring the change in loop impedance between the neutral electrode applied to the body surface and the ablation electrode in the target ablation area. This impedance change is used to assess the ablation progress. Taking intravascular radiofrequency ablation as an example, as high-frequency radiofrequency energy is applied, the ion mobility in human tissue increases, and the conductivity of the ionic solution increases with temperature. Therefore, as the tissue heats up, the current resistance decreases, resulting in a decrease in impedance measurement. Thus, in existing intravascular radiofrequency ablation techniques, the ablation status is typically obtained by measuring the change in loop impedance between the neutral electrode applied to the skin and the radiofrequency electrode inside the blood vessel.
[0048] However, there is a certain distance between the ablation electrode located in the target ablation area and the neutral electrode on the body surface, and the distance may vary. On the other hand, different target ablation objects may have tissue and anatomical differences. This may result in large differences in impedance values depending on the electrode placement or the patient, making it difficult to accurately and in real time monitor the ablation status.
[0049] In addition, there are methods that determine whether an effective ablation effect has occurred by setting a certain temperature and time for ablation. However, the temperature is obtained through a temperature sensor on the ablation electrode. Since the temperature of the contact surface between the ablation electrode and the target ablation area is not the temperature of the target ablation depth, this method of obtaining the ablation temperature by setting a sensor on the ablation electrode cannot accurately determine the ablation status.
[0050] Based on this, this application proposes an ablation status assessment device, method, and computer-readable storage medium. The ablation status assessment device detects the impedance information between two electrodes located within the ablation region through a first impedance detection circuit, and then, based on the obtained impedance information, the ablation status assessment module accurately and in real time assesses the ablation status.
[0051] Please refer to Figure 1. Figure 1 is a schematic diagram of the architecture of the ablation status judgment device provided in the embodiment of this application. This application provides an ablation status judgment device 1000, which is applied to an ablation device including multiple ablation electrodes. The ablation status judgment device 1000 includes a first impedance detection circuit 100 and an ablation status judgment module 200.
[0052] Multiple ablation electrodes come into contact with the tissue wall during ablation and release ablation energy; taking intravascular radiofrequency ablation as an example, during the ablation process, the radiofrequency electrode comes into contact with the inner wall of the blood vessel and releases radiofrequency energy.
[0053] The first impedance detection circuit 100 in the ablation condition judgment device 100 provided in this application embodiment is connected to multiple ablation electrodes and is used to detect the first impedance information between ablation electrode pairs composed of two ablation electrodes.
[0054] In the above process, the first impedance information refers to the volumetric impedance information between the two ablation electrodes within the ablation area. In intravascular radiofrequency ablation, the first impedance information is the volumetric impedance along the length of the blood vessel. This overcomes the problem in existing technologies where the distance between the radiofrequency electrode and the neutral electrode may be inconsistent, and tissue and anatomical differences can lead to significant variations in impedance values and the degree of impedance reduction among different patients. For a given target ablation object, the difference in impedance values along the length of the blood vessel is not significant. Therefore, collecting changes in volumetric impedance values along the arterial length can more accurately reflect the actual ablation status of the target ablation point.
[0055] The ablation status judgment module 200 is connected to the first impedance detection circuit 100 mentioned above. The ablation status judgment module 200 is configured to acquire first impedance information and judge the current ablation status based on the first impedance information.
[0056] This impedance detection circuit can flexibly measure the first impedance information between pairs of ablation electrodes, either in real time or time-division. For example, suppose there are six ablation electrodes, namely ablation electrode 1 to ablation electrode 6, each corresponding to an ablation point. When it is desired to determine the ablation status of the target ablation point corresponding to ablation electrode 1, the first impedance detection circuit 100 can detect five first impedance information pairs: ablation electrode 1 and ablation electrode 2, ablation electrode 1 and ablation electrode 3, ablation electrode 1 and ablation electrode 4, ablation electrode 1 and ablation electrode 5, and ablation electrode 1 and ablation electrode 6. After obtaining these five first impedance information pairs, the ablation status judgment module 200 determines the ablation status of the circumference of ablation electrode 1 (ablation electrodes are usually arranged in a spiral circumference) based on these five first impedance information pairs.
[0057] Similarly, as ablation proceeds, the temperature of the target ablation area should gradually increase, and the impedance between the two electrodes should also decrease. The ablation status judgment device can determine the ablation progress based on the decreasing trend, or determine whether the target ablation effect has been achieved.
[0058] As shown in Figure 1, the ablation status judgment device 1000 provided in this embodiment detects the first impedance information between the target ablation electrode pairs through the first impedance detection circuit 100, and analyzes the first impedance information through the ablation status judgment module 200 to obtain the current ablation status. Therefore, the ablation status judgment device 1000 provided in this embodiment has high real-time performance and accuracy in judging the ablation status because the first impedance detection circuit 100 detects the first impedance information between each pair of ablation electrodes within the ablation area. Real-time and accurate control of the ablation status can not only greatly avoid damage to non-target tissues caused by over-ablation, but also avoid poor ablation effects due to insufficient ablation time.
[0059] In an optional embodiment, the first impedance detection circuit 100 provided in this application embodiment can measure the first impedance information between the ablation electrode pairs composed of two ablation electrodes along the tissue wall of the ablation region. Please refer to Figure 2 for details. Figure 2 is a schematic diagram of the first impedance detection circuit provided in this application embodiment. In an optional embodiment of this application embodiment, the first impedance detection circuit 100 includes a first impedance measurement unit 110 and a plurality of first impedance detection switches 120.
[0060] Each first impedance detection switch 120 is connected to the first impedance measurement unit 110 and an ablation electrode; that is, each ablation electrode is equipped with a first impedance detection switch 120 to control the connection and disconnection between the ablation electrode and the first impedance measurement unit 110.
[0061] The first impedance detection switch 120 is configured to form a first impedance detection path for the target ablation electrode pair when the corresponding first impedance detection switch 120 of the target ablation electrode pair is closed.
[0062] The first impedance measurement unit 110 is configured to measure the first impedance information between the target ablation electrode pair.
[0063] The first impedance measurement unit 110 is an impedance measurement unit that can measure the first impedance information between two ablation electrodes.
[0064] Please refer to Figure 3, which is a structural example diagram of the first impedance measurement unit provided in the embodiment of this application. As shown in Figure 3, points a and b can be regarded as an ablation electrode pair composed of two ablation electrodes. In Figure 3, R represents the volume impedance between points a and b, which is the first impedance information in the embodiment of this application.
[0065] As shown in Figure 3, a differential operational amplifier is connected between points a and b. Is is a current signal of 30k-100kΩ (this current signal can generate a voltage difference across human tissue). R1 and R2, as well as R1* and R2*, are known resistance values. REFThis is a known reference voltage. Vo is the output of amplifier U1, which can be actually acquired.
[0066] The current signal Is flows through points a and b, forming a voltage difference between them. If we assume the voltage at point a is Va and the voltage at point b is Vb, and R1 = R1* and R2 = R2*, then Vo = (Va - Vb)*(R2 / R1) + Vref, we can find the value of (Va - Vb). Since Va - Vb = Is*R, we can obtain the impedance value of R.
[0067] For example, ablation electrode 1 is connected to the first impedance measurement unit 110 via its corresponding first impedance detection switch 120, and ablation electrode 2 is also connected to the first impedance measurement unit 110 via its corresponding first impedance detection switch 120. If the target research electrode pair is a target ablation electrode pair composed of ablation electrode 1 and ablation electrode 2, when the first impedance detection switches 120 corresponding to ablation electrode 1 and ablation electrode 2 are both closed, a loop can be formed between ablation electrode 1, ablation electrode 2, and the first impedance detection unit, and the first impedance detection unit can then obtain the first impedance information between ablation electrode 1 and ablation electrode 2. To obtain the first impedance information between ablation electrode 1 and other ablation electrodes, or the first impedance information between other ablation electrodes, simply close the corresponding first impedance detection switch 120. The principle is as described above and will not be repeated here.
[0068] As shown in Figures 2 and 3, the first impedance detection circuit 100 and multiple first impedance detection switches 120 in the ablation status judgment device 1000 provided in this embodiment are connected to realize impedance measurement between pairs of ablation electrodes. In other words, the ablation status judgment device 1000 provided in this embodiment can quickly and flexibly measure the first impedance information between different electrode pairs, and can realize real-time monitoring of the ablation status at each ablation point in the target ablation area.
[0069] Please refer to Figure 4, which is a first example diagram of the first impedance detection circuit of the ablation condition judgment device provided in the embodiment of this application; in an optional embodiment, the first impedance detection switch 120 includes a first terminal switch 121 and a second terminal switch 122.
[0070] The first terminal switch 121 connects the first terminal of the first impedance measurement unit 110 to the target ablation electrode.
[0071] The second terminal switch 122 connects the second terminal of the first impedance measurement unit 110 to the target ablation electrode.
[0072] The first terminal switch 121 and the second terminal switch 122 are configured to form a first impedance detection path for a target ablation electrode pair, including the first target ablation electrode and the second target ablation electrode, when the first terminal switch 121 corresponding to the first target ablation electrode and the second terminal switch 122 corresponding to the second target electrode are closed, or when the second terminal switch 122 corresponding to the first target ablation electrode and the first terminal switch 121 corresponding to the second target electrode are closed.
[0073] It should be noted that in the above process, the first terminal switch 121 and the second terminal switch 122 can be two independent switches as shown in Figure 4, or they can be replaced by a single-pole double-throw switch. This allows the ablation electrode to be connected to both ends of the first ablation impedance measurement unit via the control switches, enabling coordination with any other ablation electrode to form an impedance measurement circuit.
[0074] For example, as shown in FIG4, the first end switch of ablation electrode 1 is K1 and the second end switch is K2; the first end switch of ablation electrode 2 is K3 and the second end switch is K4; the first end switch of ablation electrode 3 is K5 and the second end switch is K6; the first end switch of ablation electrode 4 is K7 and the second end switch is K8; the first end switch of ablation electrode 5 is K9 and the second end switch is K10; and the first end switch of ablation electrode 6 is K11 and the second end switch is K12.
[0075] K1, K3, K5, K7, K9, and K11 are connected to the first terminal of the first impedance measurement unit 110; K2, K4, K6, K8, K10, and K12 are also connected to the first terminal of the first impedance measurement unit 110. When K1 and K4 are closed, the first impedance between ablation electrode 1 and ablation electrode 2 can be obtained.
[0076] To study the ablation status of the target ablation point corresponding to ablation electrode 1, the following operations can be performed: Close K1 and K4, and record the first impedance R12 between ablation electrode 1 and ablation electrode 2; close K1 and K6, and record the first impedance R13 between ablation electrode 1 and ablation electrode 3; close K1 and K8, and record the first impedance R14 between ablation electrode 1 and ablation electrode 4; close K1 and K10, and record the first impedance R15 between ablation electrode 1 and ablation electrode 5; close K1 and K12, and record the first impedance R16 between ablation electrode 1 and ablation electrode 6.
[0077] To study the ablation status of the target ablation point corresponding to ablation electrode 1, the following operations can be performed: Close K2 and K3, and record the first impedance R12 between ablation electrode 1 and ablation electrode 2; close K2 and K5, and record the first impedance R13 between ablation electrode 1 and ablation electrode 3; close K2 and K7, and record the first impedance R14 between ablation electrode 1 and ablation electrode 4; close K2 and K9, and record the first impedance R15 between ablation electrode 1 and ablation electrode 5; close K2 and K11, and record the first impedance R16 between ablation electrode 1 and ablation electrode 6.
[0078] The collected R12, R13, R14, R15, and R16 are acquired by the ablation status judgment module 200. The ablation status judgment module 200 analyzes the ablation status of the target ablation point corresponding to the ablation electrode 1 based on the collected six first impedances.
[0079] Similarly, the determination of the ablation status of the target ablation points corresponding to other ablation electrodes follows the same principle as the above process and will not be repeated here.
[0080] As shown in Figure 4, this application embodiment provides an example of a first impedance detection circuit 100, offering a first method for detecting the first impedance information between pairs of ablation electrodes. Each electrode is connected to both ends of the first impedance detection unit via a switch. By switching the switches on and off, different combinations of ablation electrodes are achieved, allowing for the measurement of the first impedance between different pairs of ablation electrodes. By measuring the first impedance information between the target ablation electrode and other ablation electrodes, the ablation status of the target ablation point corresponding to the target ablation electrode can be determined. This not only overcomes the inaccuracy and individual differences in impedance acquisition from the ablation electrode to the body surface electrode in traditional methods, but also enables precise and real-time acquisition of the ablation status of the target ablation area, ensuring the safety and effectiveness of smile surgery.
[0081] In an optional embodiment, the ablation status determination device 1000 further includes a plurality of ablation switches 300 and a wall adhesion detection circuit 400 having a plurality of wall adhesion detection switches 410.
[0082] Each ablation switch 300 is connected to a wall adhesion detection circuit 400 and an ablation electrode. The ablation switch 300 is configured to form a wall adhesion detection circuit including the ablation electrode and the wall adhesion detection circuit 400 when the ablation switch 300 and the corresponding wall adhesion detection switch 410 are closed.
[0083] Please refer to Figure 5, which is an example diagram of adding a wall-mounted detection circuit 400 to the first example diagram of the first impedance detection circuit 100 provided in this application embodiment. As shown in Figure 5, the wall-mounted detection circuit 400 also includes a neutral electrode 420 and a second impedance measurement unit 430.
[0084] A neutral electrode 420 is placed on the surface of the target ablation object. The first end of the second impedance measurement unit 430 is connected to multiple ablation electrodes via multiple wall-mounted detection switches 410. The second end of the second impedance measurement unit 430 is connected to the neutral electrode 420.
[0085] The second impedance measurement unit 430 is configured to measure the second impedance information between the neutral electrode 420 and the ablation electrode corresponding to the wall-attachment detection switch 410 when the wall-attachment detection switch 410 and the corresponding ablation switch 300 are closed.
[0086] In simple terms, this application implements a method to test the adhesion performance of the ablation electrode by measuring the second impedance between the ablation electrode and the target ablation object's body surface at the beginning of ablation. The main part of the impedance measurement in this embodiment is the second impedance measurement unit 430. For each ablation electrode, a wall adhesion detection switch 410 is provided between the second impedance measurement unit 430 and the target ablation electrode. When the ablation energy has begun to be released (i.e., the ablation switch 300 is already closed), closing the corresponding wall adhesion detection switch 410 can form a second impedance measurement circuit between the target ablation electrode and the neutral electrode 420 on the body surface.
[0087] For example, as shown in Figure 5, the ablation switches 300 are OUT+ and OUT-, and the wall adhesion detection switch 410 is RF; in Figure 4, OUT1+ to OUT6+ are the ablation switches 300 for ablation electrodes 1 to ablation electrodes 6, and the wall adhesion detection switches 410RF1, RF2, RF3, RF4, RF5 and RF6 in Figure 4 are the wall adhesion detection switches 410 for ablation electrodes 1, ablation electrodes 2, ablation electrodes 3, ablation electrodes 4, ablation electrodes 5 and ablation electrodes 6 respectively.
[0088] During ablation, the ablation switches 300 (OUT+ and OUT-) are typically closed to activate radio frequency energy. First, it's checked whether the ablation electrodes are properly attached to the wall. Proper attachment is achieved through the wall-attachment detection circuit 400. Then, based on this, the corresponding wall-attachment detection switch 410 (RF) is closed. For example, as shown in Figure 4, assuming the second impedance between ablation electrode 1 and the neutral electrode 420 is to be measured, OUT1+ and OUT- for ablation electrode 1 are closed, and RF1 is also closed. Then, the second impedance measurement unit 430 can measure the second impedance information between ablation electrode 1 and ablation electrode 2.
[0089] It is understandable that the second impedance information is the impedance between the ablation electrode located in the ablation area and the surface electrode of the target ablation object. Based on empirical data, the adhesion between the ablation electrode and the target ablation tissue wall can be judged by the second impedance information between the target ablation electrode and the neutral electrode 420. If the adhesion is good, the second impedance will be relatively stable within the preset impedance range; if the adhesion is poor, the second impedance may fluctuate or be outside the preset impedance range.
[0090] Poor adhesion can lead to ineffective ablation, failing to effectively ablate the target ablation point and making it impossible to accurately detect the initial impedance information between the two ablation electrodes. In such cases, intervention measures are necessary, such as readjusting the electrode positions. Therefore, assessing the adhesion of the ablation electrodes at the beginning of ablation is crucial for improving ablation effectiveness and efficiency.
[0091] As shown in Figure 5, the ablation status judgment device 1000 provided in this embodiment of the application is provided with a wall adhesion detection circuit 400. The wall adhesion detection circuit 400 can measure the second impedance information between the target ablation electrode and the neutral electrode 420 disposed on the surface of the ablation object. Based on the second impedance information, the wall adhesion of the target ablation electrode can be determined, thereby achieving effective ablation and ensuring that the first impedance information between the two ablation electrodes is available, which is beneficial to accurately grasp the ablation status of the target ablation area.
[0092] In an optional embodiment, the first impedance detection switch 120 includes a first switch 123 and a second switch 124.
[0093] The first switch 123 connects the first terminal of the first impedance measurement unit 110 to the first target ablation electrode. The second switch 124 connects the second terminal of the first impedance measurement unit 110 to the second target ablation electrode.
[0094] The first switch 123 and the second switch 124 are configured such that, when the first switch 123 and the second switch 124 are closed, they form a first impedance measurement path including a first target ablation electrode, a second target ablation electrode and a first impedance measurement unit 110.
[0095] For example, please refer to Figure 6, which is a second example diagram of the first impedance detection circuit of the ablation condition judgment device provided in the embodiments of this application; there are 6 ablation electrodes in Figure 4, namely ablation electrode 1 to ablation electrode 6, each ablation electrode corresponding to one ablation point. In Figure 6, there are 12 ablation electrodes, with every two ablation electrodes corresponding to one ablation point.
[0096] In Figure 6, ablation electrode 11 is connected to the first switch K11, and ablation electrode 12 is connected to the second switch K12; ablation electrodes 11 and 12 together ablate ablation point 1. Ablation electrode 21 is connected to the first switch K21, and ablation electrode 22 is connected to the second switch K22; ablation electrodes 21 and 22 together ablate ablation point 2. Ablation electrode 31 is connected to the first switch K31, and ablation electrode 32 is connected to the second switch K32; ablation electrodes 31 and 32 together ablate ablation point 3. Ablation electrode 41 is connected to the first switch K41, and ablation electrode 42 is connected to the second switch K42; ablation electrodes 41 and 42 together ablate ablation point 4. Ablation electrode 51 is connected to the first switch K51, and ablation electrode 52 is connected to the second switch K52; ablation electrodes 51 and 52 together ablate ablation point 5. The ablation electrode 61 is connected to the first switch K61, and the ablation electrode 62 is connected to the second switch K62; the ablation electrode 61 and the ablation electrode 62 together ablate the ablation point 6.
[0097] Taking ablation point 1 as an example, the first switch K11 and the second switch K12 are closed to form a first impedance measurement path including ablation electrode 11, ablation electrode 12 and a first impedance measurement unit 110, so as to realize the measurement of the first impedance information between ablation electrode 11 and ablation electrode 12.
[0098] It should be noted that the structure of the first impedance detection circuit 100 provided in the second example diagram of the embodiment of this application can still be superimposed on the wall-attachment detection circuit 400 described above, so as to realize the judgment of the wall-attachment of the ablation electrode at the beginning of ablation. The principle will not be repeated here.
[0099] Therefore, the structure of the second example diagram of the first impedance detection circuit 100 provided in this application replaces the one ablation point corresponding to one ablation electrode with one ablation point corresponding to two ablation electrodes; thus, the implementation architecture for measuring the impedance between two points in the target ablation area to understand the ablation situation is simpler, and the ablation situation can be understood efficiently and accurately with a simpler structure.
[0100] Please refer to Figure 7, which is a second schematic diagram of the architecture of the ablation status determination device provided in the embodiment of this application; in an optional embodiment, the ablation status determination device 1000 further includes a temperature detection module 500.
[0101] The temperature detection module 500 is connected to the ablation status judgment module 200 and configured to detect the temperature information of the target ablation area.
[0102] The ablation status judgment module 200 is also configured to judge the current ablation status based on the first impedance information and temperature information.
[0103] In addition to the above-mentioned method of judging the ablation status of the target ablation region based on the first impedance information, a temperature detection module 500 can be added to the ablation status judgment device 1000 provided in this application embodiment. The temperature detection module 500 realizes the temperature detection of the target ablation region and adds the measured temperature information to the judgment of the ablation status.
[0104] Optionally, please refer to Figures 8 and 9. Figure 8 is an example diagram of the first setting position of the temperature detection module provided in the embodiment of this application; Figure 9 is an example diagram of the second setting position of the temperature detection module provided in the embodiment of this application. In Figures 8 and 9, taking a mesh support as an example, an ultrasonic source is set on the central operating wire of the mesh support. Figures 8 and 9 show two different ways of setting the ultrasonic source.
[0105] The ultrasound source emits ultrasound and collects the echo signals to determine the temperature of the current ablation point and the tissue condition at a certain depth. That is, the transmission rate of ultrasound is related to the tissue density, so it can be used to determine the ablation status and the ablation status of a single point.
[0106] The frequency, power, and acquisition depth of ultrasound are related; in addition, ultrasound can be set to emit ultrasound waves in all directions, thereby imaging the ablation site from all sides.
[0107] In Figure 8, the ultrasound source is positioned in the center of the central operating wire, while in Figure 9, the ultrasound sources are distributed at three different locations on the central operating wire. Besides the two ultrasound source configurations shown in Figures 8 and 9, the ultrasound source can also be positioned at other locations, as long as it allows for good imaging of the ablation area. It should be noted that the electrode configurations shown in Figures 8 and 9 involve two ablation electrodes per ablation point, with each figure including 12 electrodes. In some embodiments, the electrode configuration can also be one ablation electrode per ablation point, for a total of 6 ablation electrodes. In some embodiments, the number of ablation points or ablation electrodes can be increased or decreased adaptively according to actual needs.
[0108] It is worth noting that, since the ultrasonic source provided in this application embodiment is an ultrasonic transducer with a polygonal cross-section, each surface of the transducer can emit ultrasonic signals; therefore, the temperature detection module 500 provided in this application embodiment measures the temperature of the ablation area in real time, detecting the real-time ablation temperature within a certain depth.
[0109] Specifically, the temperature detection module 500 provided in this application embodiment measures temperature in the following way: Before ablation, an echo signal is first acquired by an ultrasonic transducer and converted into an image, which serves as a reference image. Then, during ablation, an image of a certain ablation depth at the ablation site is acquired in real time by the ultrasonic transducer. The temperature at a certain depth at the ablation site is determined by comparing the image with the grayscale value of the reference image. Please refer to Figure 10, which is a comparison of the ultrasonic image (a) of the target ablation tissue before ablation and the ultrasonic image (b) after ablation provided in this application embodiment. In (a), the white dots within the white box area represent the positions of the ablation electrodes before ablation. Within the white box area in (a), the range of white dots gradually expands as radiofrequency ablation progresses. After performing difference processing and wavelet transform analysis on the ultrasound images before and after ablation, their grayscale texture feature parameters are extracted and linear correlation fitting analysis is performed with temperature to obtain the relationship between grayscale value and temperature change. Please refer to Figure 11 for reference. Figure 11 is an example diagram of the relationship between grayscale value and temperature change provided in the embodiment of this application. As can be seen from Figure 11, as the ablation temperature increases, the grayscale value gradually increases. The current ablation temperature can be determined by the relationship between grayscale value and temperature change.
[0110] As shown in Figures 7 to 11, the ablation status assessment device 1000 provided in this embodiment of the application, by adding a temperature detection module 500, monitors the real-time ablation temperature at a certain depth in the target ablation area. This can be used in conjunction with the first impedance information to provide a more comprehensive assessment of the ablation status. This helps to more accurately monitor and control the ablation process, avoiding tissue damage caused by overheating or insufficient ablation due to excessively low temperatures, further improving the safety and efficacy of the procedure.
[0111] In an optional embodiment of this application, the ablation status determination module 200, in the process of determining the current ablation status based on the first impedance information and temperature information, is specifically used for:
[0112] Determine whether the decrease in the first impedance information reaches the impedance decrease threshold, and / or determine whether the temperature information reaches the temperature threshold and remains for a preset duration.
[0113] If the decrease in the first impedance information reaches the impedance decrease threshold, and / or if the temperature information reaches the temperature threshold and is maintained for a preset duration, then the ablation endpoint is determined to have been reached.
[0114] For example, taking one ablation point corresponding to one ablation electrode as an example, suppose we want to understand the ablation status of ablation electrode 4. At the start of ablation, the impedance product between each electrode is measured and saved as basic impedance data. After a period of ablation, to study the ablation status of ablation electrode 4, K8 and K9, K8 and K11, K8 and K5, K8 and K3, and K8 and K1 are controlled to close respectively. The first impedance values between ablation electrode 4 and the other five ablation electrodes are obtained. These six impedance values are analyzed against the basic impedance data measured at the start of ablation to see if they have reached a preset decrease value, for example, all decreasing to more than 10%. Or, all five first impedance values have decreased by more than 10%. Simultaneously, if the temperature detection module 500 detects that the temperature of ablation point 4 has risen to a certain ablation depth and then remains stable for a preset period, for example, 10 seconds, it can be determined that the current ablation status has reached the ablation endpoint, and the ablation switch 300 corresponding to ablation electrode 4 can be turned off. Of course, in some embodiments, the ablation status can be determined solely based on the first impedance value between the electrodes, or solely based on the ablation temperature at a certain ablation depth.
[0115] In this embodiment of the application, when the ablation status judgment module 200 determines that the target ablation point has reached the ablation endpoint, the relevant ablation switch 300 will be turned off to stop outputting ablation energy, so as to avoid excessive ablation of the blood vessel wall and cause damage.
[0116] Therefore, it can be seen that the ablation status judgment module 200 of the ablation status judgment device 1000 provided in this application embodiment can directly determine that the ablation endpoint has been reached by the decrease of the acquired first impedance information and / or whether the temperature information of a certain ablation depth has reached the temperature threshold and maintained for a certain period of time. Otherwise, ablation continues. Therefore, the ablation status judgment device 1000 provided in this application embodiment can achieve efficient and accurate control of the ablation status by analyzing the collected data through the ablation status judgment module 200.
[0117] In an optional embodiment, the ablation status judgment device 1000 provided in this application embodiment is further provided with a display module, which can display the measured first impedance information, second impedance information, temperature information, and ablation status of the ablation channel.
[0118] Please refer to Figure 12, which is a flowchart of the ablation endpoint determination method provided in an embodiment of this application. This application provides an ablation endpoint determination method applied to an ablation status determination device, which includes a first impedance detection circuit and an ablation status determination module. This ablation endpoint determination method can be implemented by the electronic device shown in Figure 12, and includes the following steps:
[0119] Step S100: The first impedance information between the target ablation electrode and other ablation electrodes is obtained by the first impedance detection circuit.
[0120] In step S100 above, the first impedance detection circuit detects the first impedance information between the target electrode and other ablation electrodes. The ablation electrodes in this embodiment include a target ablation electrode and other ablation electrodes, which are attached to the target ablation tissue wall and used to release ablation energy.
[0121] Optionally, the impedance information between the target ablation electrode and another ablation electrode is measured in a time-sharing manner until the impedance information between the target ablation electrode and all other ablation electrodes is measured; and the ablation electrodes that have not undergone impedance information measurement are controlled to output ablation energy.
[0122] For the structure in Figure 4:
[0123] When K1 and K4 (or K2 and K3) are connected, the first impedance between ablation electrode 1 and ablation electrode 2 can be measured. When K1 and K6 (or K2 and K5) are connected, the first impedance between ablation electrode 1 and ablation electrode 3 can be measured. When K1 and K8 (or K2 and K7) are connected, the first impedance between ablation electrode 1 and ablation electrode 4 can be measured. When K1 and K10 (or K2 and K9) are connected, the first impedance between ablation electrode 1 and ablation electrode 5 can be measured. When K1 and K12 (or K2 and K11) are connected, the first impedance between ablation electrode 1 and ablation electrode 6 can be measured.
[0124] When K3 and K6 (or K4 and K5) are connected, the first impedance between ablation electrode 2 and ablation electrode 3 can be measured. When K3 and K8 (or K4 and K7) are connected, the first impedance between ablation electrode 2 and ablation electrode 4 can be measured. When K3 and K10 (or K4 and K9) are connected, the first impedance between ablation electrode 2 and ablation electrode 5 can be measured. When K3 and K12 (or K4 and K11) are connected, the first impedance between ablation electrode 2 and ablation electrode 6 can be measured.
[0125] When K5 and K8 (or K6 and K7) are connected, the first impedance between ablation electrode 3 and ablation electrode 4 can be measured; when K5 and K10 (or K6 and K9) are connected, the first impedance between ablation electrode 3 and ablation electrode 5 can be measured; when K5 and K12 (or K6 and K11) are connected, the first impedance between ablation electrode 3 and ablation electrode 6 can be measured.
[0126] When K7 and K10 (or K8 and K9) are connected, the first impedance between ablation electrode 4 and ablation electrode 5 can be measured; when K7 and K12 (or K8 and K11) are connected, the first impedance between ablation electrode 4 and ablation electrode 6 can be measured.
[0127] When K9 and K12 (or K10 and K11) are connected, the first impedance between ablation electrode 5 and ablation electrode 6 can be measured.
[0128] When it is necessary to measure the corresponding first impedance, the corresponding switch is controlled to open or close.
[0129] Step S200: The ablation status judgment circuit determines whether the target ablation point corresponding to the target electrode has reached the ablation endpoint based on the impedance information.
[0130] In step S200 above, taking one ablation point corresponding to one ablation electrode as an example, assuming we want to understand the ablation status of ablation electrode 4, at the start of ablation, the impedance product between each electrode is measured and saved as basic impedance data. After a period of ablation, to study the ablation status of ablation electrode 4, K8 and K9, K8 and K11, K8 and K5, K8 and K3, and K8 and K1 are controlled to be closed respectively. The first impedance values between ablation electrode 4 and the other five ablation electrodes are obtained. These six impedance values are analyzed with the basic impedance data measured at the start of ablation to see if they have reached a preset decrease value, for example, all decreasing to more than 10%. Or, if all five first impedance values have decreased by more than 10%, it is determined whether the ablation point corresponding to ablation electrode 4 has reached the ablation endpoint.
[0131] When the decrease in the first impedance value between the ablation electrodes corresponding to all ablation points reaches the preset decrease value, the entire ablation procedure can be stopped.
[0132] In an optional embodiment, the ablation status determination module further includes a wall adhesion detection circuit; before obtaining the impedance information between the target ablation electrode and other ablation electrodes, the ablation endpoint determination method further includes: the wall adhesion detection circuit detecting the adhesion of the ablation electrodes, including the target ablation electrode and other ablation electrodes, to the wall of the ablated tissue.
[0133] In an optional embodiment, the ablation temperature at a certain ablation depth can be obtained by a temperature detection module, such as an ultrasonic transducer, installed in the ablation determination device. The ablation endpoint is then determined based on the temperature and the time it takes for the temperature to stabilize.
[0134] As shown in Figure 12, existing technologies for determining the ablation endpoint using methods such as fixed time, fixed output energy, and impedance changes are indirect methods. Since nerves are typically distributed around the vessel wall, this traditional method of determining the ablation endpoint is closely related to the reliability of the radiofrequency electrode's adhesion to the vessel wall. The temperature sensor on the radiofrequency electrode collects the temperature of the electrode-tissue contact surface, not the temperature at a specific ablation depth. Relying solely on ablation timing or the number of ablation points allows for subjective judgments based on historical data, indirectly assuming nerve damage, and cannot accurately and reliably determine whether the nerve has been ablated. Another method uses electrical stimulation of the renal artery sympathetic nerve or ganglion to assess blood pressure changes and other physiological indicators to determine the ablation endpoint; however, the timing of sympathetic nerve modulation varies among patients, making it impossible to establish a unified indicator. The ablation endpoint determination method provided in this application is based on the volumetric impedance value changes along the artery length collected by the ablation endpoint determination device, which better reflects the actual ablation effect at the ablation point. Simultaneously, an all-around ultrasonic transducer can be installed at the center of the catheter to detect the actual ablation temperature within a certain depth in real time. This allows for a direct and intuitive assessment of the degree of nerve damage achieved by the ablation, and accurate and timely determination of the ablation endpoint.
[0135] Please refer to Figure 13, which is a schematic diagram of the structure of an electronic device provided in an embodiment of this application. An electronic device 600 provided in this application includes: a processor 601 and a memory 602. The memory 602 stores machine-readable instructions executable by the processor 601. When the machine-readable instructions are executed by the processor 601, they perform steps in any implementation of the above-described ablation determination method.
[0136] Based on the same inventive concept, embodiments of this application also provide a computer-readable storage medium storing computer program instructions. When the computer program instructions are read and executed by a processor, they perform the steps in any implementation of the above-described ablation determination method.
[0137] The computer-readable storage medium can be any medium capable of storing program code, such as Random Access Memory (RAM), Read Only Memory (ROM), Programmable Read-Only Memory (PROM), Erasable Programmable Read-Only Memory (EPROM), Electrically Erasable Programmable Read-Only Memory (EEPROM).
[0138] In this document, relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, without necessarily requiring or implying any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising..." does not exclude the presence of additional identical elements in the process, method, article, or apparatus that includes said element.
[0139] The above description is merely an embodiment of this application and is not intended to limit the scope of protection of this application. Various modifications and variations can be made to this application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the scope of protection of this application.
Claims
1. A device for determining ablation status, characterized in that, The ablation status assessment device is applied to an ablation device that includes multiple ablation electrodes. The ablation status assessment device includes: a first impedance detection circuit and an ablation status assessment module. The first impedance detection circuit is connected to multiple ablation electrodes and configured to detect first impedance information between the target ablation electrode pairs; The ablation status judgment module is connected to the first impedance detection circuit. The ablation status judgment module is configured to acquire the first impedance information and judge the current ablation status based on the first impedance information.
2. The ablation determination device according to claim 1, characterized in that, The first impedance detection circuit includes a first impedance measurement unit and a plurality of first impedance detection switches; Each of the first impedance detection switches is connected to the first impedance measurement unit and one of the ablation electrodes; The first impedance detection switch is configured to form a first impedance detection path for the target ablation electrode pair when the corresponding first impedance detection switch of the target ablation electrode pair is closed. The first impedance measurement unit is configured to measure the first impedance information between the target ablation electrode pair.
3. The ablation determination device according to claim 2, characterized in that, The first impedance detection switch includes a first terminal switch and a second terminal switch; The first terminal switch connects the first terminal of the first impedance measurement unit to the target ablation electrode; The second terminal switch connects the second terminal of the first impedance measurement unit to the target ablation electrode; The first terminal switch and the second terminal switch are configured to form a first impedance detection path for a target ablation electrode pair, including the first target ablation electrode and the second target ablation electrode, when the first terminal switch corresponding to the first target ablation electrode and the second terminal switch corresponding to the second target electrode are closed, or when the second terminal switch corresponding to the first target ablation electrode and the first terminal switch corresponding to the second target electrode are closed.
4. The ablation determination device according to claim 3, characterized in that, The ablation status determination device also includes multiple ablation switches and a wall-attachment detection circuit with multiple wall-attachment detection switches; Each of the ablation switches is connected to the wall adhesion detection circuit and an ablation electrode. The ablation switch is configured to form a wall adhesion detection loop including the ablation electrode and the wall adhesion detection circuit when the ablation switch and the corresponding wall adhesion detection switch are closed.
5. The ablation status determination device according to claim 4, characterized in that, The wall-attachment detection circuit also includes a neutral electrode and a second impedance measurement unit; The neutral electrode is disposed on the surface of the target ablation object; The first end of the second impedance measurement unit is connected to the plurality of ablation electrodes respectively through the plurality of wall-mounted detection switches; The second end of the second impedance measuring unit is connected to the neutral electrode; The second impedance measurement unit is configured to measure the second impedance information between the neutral electrode and the ablation electrode corresponding to the wall-attachment detection switch when the wall-attachment detection switch is closed and the corresponding ablation switch is closed.
6. The ablation determination device according to claim 2, characterized in that, The first impedance detection switch includes a first switch and a second switch; The first switch connects the first terminal of the first impedance measurement unit to the first target ablation electrode; The second switch is connected to the second terminal of the first impedance measurement unit and the second target ablation electrode; The first switch and the second switch are configured to form a first impedance measurement path, including the first target ablation electrode, the second target ablation electrode and the first impedance measurement unit, when the first switch and the second switch are closed.
7. The ablation determination device according to claim 1, characterized in that, The ablation determination device also includes a temperature detection module; The temperature detection module is connected to the ablation status judgment module and is configured to detect the temperature information of the target ablation area; The ablation status judgment module is further configured to judge the current ablation status based on the first impedance information and temperature information.
8. The ablation determination device according to claim 7, characterized in that, The ablation status determination module, in determining the current ablation status based on the first impedance information and temperature information, is specifically used for: Determine whether the decrease in the first impedance information reaches the impedance decrease threshold, and / or determine whether the temperature information reaches the temperature threshold and remains for a preset duration; If the decrease in the first impedance information reaches the impedance decrease threshold, and / or if the temperature information reaches the temperature threshold and is maintained for a preset duration, then the ablation endpoint is determined to have been reached.
9. A method for determining the ablation endpoint, characterized in that, This ablation endpoint determination method is applied to an ablation status assessment device, which includes a first impedance detection circuit and an ablation status assessment module; the ablation endpoint determination method includes: The first impedance detection circuit obtains the first impedance information between the target ablation electrode and other ablation electrodes; The ablation status judgment circuit determines, based on the impedance information, whether the target ablation point corresponding to the target electrode has reached the ablation endpoint. The target ablation electrode and other ablation electrodes are attached to the target ablation tissue wall and are used to release ablation energy.
10. The method for determining the ablation endpoint according to claim 9, characterized in that, The ablation status determination module further includes a wall adhesion detection circuit; before acquiring the impedance information between the target ablation electrode and other ablation electrodes, the ablation endpoint determination method further includes: The adhesion detection circuit detects the adhesion of the ablation electrode, including the target ablation electrode and other ablation electrodes, to the wall of the ablated tissue.
11. The method for determining the ablation endpoint according to claim 9, characterized in that, The acquisition of the first impedance information between the target ablation electrode and other ablation electrodes includes: The impedance information between the target ablation electrode and another ablation electrode is measured in time-division until the impedance information between the target ablation electrode and all other ablation electrodes is measured. In addition, control the output ablation energy of ablation electrodes that have not undergone impedance information measurement.
12. A computer-readable storage medium, characterized in that, The computer-readable storage medium stores computer program instructions that, when executed by a processor, perform the steps of the method according to any one of claims 9-11.