Fungal expression systems with reduced volatile compounds

Disrupting the PpoC gene in Aspergillus hosts reduces volatile compounds like 1-octen-3-ol, enhancing sensory properties and reducing production costs by minimizing odor and flavor removal processes.

WO2026125306A1 Publication Date: 2026-06-18NOVOZYMES AS
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
NOVOZYMES AS
Filing Date
2025-12-09
Publication Date
2026-06-18

AI Technical Summary

⚠Technical Problem

Fungal expression systems, particularly Aspergillus, produce volatile compounds like 1-octen-3-ol that contribute to undesirable odor and flavor profiles in food and beverage applications, leading to increased production costs due to the need for odor and flavor removal processes.

⚗Method used

Disrupting the central metabolic pathway of 1-octen-3-ol production by reducing or eliminating the expression of the psi-producing oxygenase C (PpoC) gene in Aspergillus hosts, without affecting cell growth or performance.

🎯Benefits of technology

Reduces volatile compounds, thereby improving sensory properties and lowering production costs by minimizing the need for downstream odor and flavor removal processes.

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Abstract

The present invention relates to Aspergillus mutants with reduced or eliminated expression and / or activity of an endogenous psi-producing oxygenase C (PpoC) comprising in its genome one or more polynucleotide encoding a polypeptide of interest heterologous to the mutant cell, methods of producing a polypeptide of interest using said host cells, as well as the use of said cells in production methods to provide fermentation products comprising reduced volatile agents.
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