Liquid oral composition

Abstract

The present invention aims to provide a liquid oral composition that contains no ethyl alcohol and in which the generation of precipitates during storage at high temperatures can be sufficiently suppressed. Specifically, the present invention provides a liquid oral composition that is substantially free of ethyl alcohol, and comprises dextranase as a component (A), and xanthan gum as a component (B), and preferably further comprises a component (C). It is preferable that at least one of the following conditions is satisfied: the content of component (A) is 0.0077 to 1.54% by mass; the content of component (B) is 0.01 to 1.0% by mass; and the mass ratio ((A) / (B)) of the content of component (A) to the content of component (B) is 0.6 to 150.

Description

Liquid oral composition 【0001】 The present invention relates to a liquid oral composition. 【0002】 Dextranase exhibits an anticaries effect by decomposing plaque in a dentifrice. For example, Patent Document 1 describes that an oral composition containing dextranase and an ester-based or ether-based nonionic surfactant suppresses the generation of precipitates produced by high-temperature storage, has excellent appearance stability, good taste, and excellent usability, and that ethyl alcohol can be incorporated when making a liquid preparation. 【0003】 Japanese Patent Application Laid-Open No. 9-175972 【0004】 However, when a liquid oral composition is prepared without adding ethyl alcohol to suppress the feeling of irritation, the generation of precipitates during high-temperature storage may not be sufficiently suppressed when dextranase is incorporated. 【0005】 An object of the present invention is to provide a liquid oral composition that does not contain ethyl alcohol and can sufficiently suppress the generation of precipitates during high-temperature storage. 【0006】 The present invention provides [1] to [5]. [1] A liquid oral composition that substantially does not contain ethyl alcohol, comprising: Component (A): dextranase, and Component (B): xanthan gum. [2] The liquid oral composition according to [1], wherein the content of Component (A) is 0.0077 to 1.54% by mass. [3] The liquid oral composition according to [1] or [2], wherein the content of Component (B) is 0.001 to 1.0% by mass. [4] The liquid oral composition according to any one of [1] to [3], wherein the mass ratio of the content of Component (A) to the content of Component (B) ((A) / (B)) is 0.6 to 150. [5] The liquid oral composition according to any one of [1] to [4], further comprising Component (C): an amino acid. 【0007】According to the present invention, in a liquid oral composition substantially free of ethyl alcohol, by including xanthan gum and water together with dextranase, the formation of precipitates during high-temperature storage can be suppressed, the clarity of the appearance can be maintained, and the stability of dextranase can be improved. 【0008】 [1. Components and Composition of Liquid Oral Composition] The liquid oral composition of the present invention contains components (A) and (B), and preferably further contains component (C). [1.1 Component (A): Dextranase] Component (A) is dextranase. Dextranase is a type of endo-type hydrolytic enzyme that hydrolyzes the α1,6-bond of dextran. Examples of dextranase include dextranase derived from dextranase-producing bacteria such as those of the genera Ketomium, Penicillium, Aspergillus, Spicaria, Lactobacillus, and Cervibrio, but any of these can be used, and two or more enzyme preparations of different origins and dosage forms may be used in combination. When dextranase is a preparation, it is preferable that the preparation contains an excipient. This can increase the stability of the enzyme. Examples of excipients include sugar alcohols such as sorbitol, mannitol, and maltitol; polysaccharides such as dextrin, starch, and crystalline cellulose; and inorganic powders such as silica, with mannitol, dextrin, and crystalline cellulose being preferred. The content of the excipient can be adjusted as appropriate and is not particularly limited. 【0009】The content of component (A) (for example, in the case of an enzyme activity of 13,000 units / g) is preferably 0.003% by mass or more, more preferably 0.005% by mass or more, even more preferably 0.006% by mass or more, even more preferably 0.007% by mass or more, particularly preferably 0.0077% by mass or more, 0.01% by mass or more, and 0.02% by mass or more. This allows the caries prevention effect of component (A) to be well exhibited. The upper limit is preferably 2.0% by mass or less, more preferably 1.8% by mass or less, even more preferably 1.7% by mass or less, even more preferably 1.6% by mass or less, particularly preferably 1.54% by mass or less, 1.2% by mass or less, and 1.0% by mass or less. This allows the caries prevention effect commensurate with the amount added to be efficiently exhibited. Therefore, preferably 0.003 to 2.0% by mass, more preferably 0.005 to 1.8% by mass, even more preferably 0.006 to 1.7% by mass, even more preferably 0.007 to 1.6% by mass, and particularly preferably 0.0077 to 1.54% by mass, 0.01 to 1.2% by mass, and 0.02 to 1.0% by mass. Note that the enzyme content as component (B) in the later examples is the content when the enzyme activity is 13,000 units / g. 【0010】 In this specification, the content of each component is based on the amount of each component used when manufacturing the oral composition. Unless otherwise specified, it refers to mass percent relative to 100% by mass of the total amount of the oral composition. 【0011】 [1.2 (B) Xanthan Gum] Component (B) is xanthan gum. Xanthan gum is a water-soluble polysaccharide that can improve the clarity, appearance stability, and stability of component (A) of the oral composition. It can also function as a thickening agent. 【0012】The content of component (B) is preferably 0.0003% by mass or more, more preferably 0.0005% by mass or more, even more preferably 0.0007% by mass or more, even more preferably 0.0009% by mass or more, particularly preferably 0.001% by mass or more, 0.0015% by mass or more, or 0.002% by mass or more. This allows the effects of component (B) to be exerted more efficiently, and in particular, the stability of appearance and the stability of component (A) can be maintained more effectively. The upper limit is preferably 2.0% by mass or less, more preferably 1.8% by mass or less, even more preferably 1.5% by mass or less, even more preferably 1.3% by mass or less, particularly preferably 1.0% by mass or less, 0.9% by mass or less, or 0.7% by mass or less. This allows the clarity of the oral composition and the stability of component (A) to be maintained more effectively. Therefore, preferably 0.0003 to 2.0 mass%, more preferably 0.0005 to 1.8 mass%, even more preferably 0.0007 to 1.5 mass%, even more preferably 0.0009 to 1.3 mass%, and particularly preferably 0.001 to 1.0 mass%, 0.0015 to 0.9 mass%, and 0.002 to 0.7 mass%. 【0013】 [1.3 Component (C): Amino Acid] Component (C) is an amino acid. By including component (C), the stability of component (A) can be improved together with component (B). 【0014】Examples of amino acids include protein-constituting amino acids such as neutral amino acids, acidic amino acids, and basic amino acids, as well as free amino acids in the body. Examples of neutral amino acids include alkyl group-containing neutral amino acids such as glycine, alanine, valine, leucine, and isoleucine; hydroxyl group-containing neutral amino acids such as serine and threonine; sulfur atom-containing amino acids such as cysteine ​​and methionine; amide group-containing amino acids such as asparagine and glutamine; imino group-containing amino acids such as proline; and aromatic group-containing amino acids such as phenylalanine, tyrosine, and tryptophan. Examples of acidic amino acids include glutamic acid and aspartic acid. Examples of basic amino acids include arginine, histidine, and lysine. Examples of free amino acids in the body include taurine, hydroxyproline, sarcosine, urea, β-alanine, ethanolamine, citrulline, cystathione, γ-aminobutyric acid, 5-hydroxy-DL-lysine, ornithine, methylhistidine, and anserine. Examples of artificial amino acids include tranexamic acid and ε-aminocaproic acid. The amino acid may be in D, L, or DL ​​(racemic) form. Of these, protein-constituting amino acids are preferred, neutral amino acids are more preferred, alkyl-containing neutral amino acids are even more preferred, and alanine is even more preferred. Component (C) may be a single type or a combination of two or more types. 【0015】The content of component (C) is preferably 0.01% by mass or more, more preferably 0.02% by mass or more, even more preferably 0.03% by mass or more, even more preferably 0.04% by mass or more, particularly preferably 0.05% by mass or more, 0.07% by mass or more, or 0.1% by mass or more. This allows the effects of component (C) to be exerted more efficiently and the stability of component (A) to be further improved. The upper limit is preferably 5.0% by mass or less, more preferably 4.0% by mass or less, even more preferably 3.0% by mass or less, even more preferably 2.0% by mass or less, particularly preferably 1.0% by mass or less, 0.8% by mass or less, or 0.5% by mass or less. This allows the effects of component (C) to be exerted in proportion to the amount added. Therefore, preferably 0.01 to 5.0% by mass, more preferably 0.02 to 4.0% by mass, even more preferably 0.03 to 3.0% by mass, even more preferably 0.04 to 2.0% by mass, and particularly preferably 0.05 to 1.0% by mass, 0.07 to 0.8% by mass, and 0.1 to 0.5% by mass. 【0016】 [1.4 Mass ratio of (A) / (B)] The mass ratio of the content of component (A) to the content of component (B) ((A) / (B)) is preferably 0.2 or more, more preferably 0.3 or more, even more preferably 0.4 or more, even more preferably 0.5 or more, particularly preferably 0.6 or more, 0.8 or more, or 1 or more. The upper limit is preferably 300 or less, more preferably 250 or less, even more preferably 200 or less, even more preferably 180 or less, particularly preferably 150 or less, 100 or less, or 80 or less. Therefore, it is preferably 0.2 to 300, more preferably 0.3 to 250, even more preferably 0.4 to 200, even more preferably 0.5 to 180, particularly preferably 0.6 to 150, 0.8 to 100, or 1 to 80. By being within the above upper limit, lower limit, or numerical range, the clarity, appearance stability, and stability improvement effects of component (A) of the oral composition can be well-balanced. 【0017】[1.5 Optional Components] The liquid oral composition of the present invention may optionally contain components other than components (A) to (C). Examples of optional components include surfactants, wetting agents, binders, solvents, fragrances, sweeteners, medicinal components, oily components, preservatives, pH adjusters, and colorants (pigments). Optional components may be present individually or in combination of two or more. 【0018】 - Surfactants - Examples of surfactants include nonionic, amphoteric, anionic, and cationic surfactants. 【0019】 Examples of nonionic surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ethers, polyoxyethylene / polyoxypropylene alkyl ethers, glycerin fatty acid esters, polyglycerin fatty acid esters, alkyl glycosides, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate), fatty acid alkylolamides, polyoxyethylene fatty acid esters, polyoxyethylene alkenyl ethers, sucrose fatty acid esters (e.g., sucrose fatty acid esters), sugar alcohol fatty acid esters (e.g., maltitol fatty acid esters, lactitol fatty acid esters), polyoxyethylene polyoxypropylene copolymers, and polyoxyethylene polyoxypropylene fatty acid esters. 【0020】The average number of moles of ethylene oxide added to polyoxyethylene hydrogenated castor oil is preferably 5 to 100 moles, more preferably 5 to 60 moles. The number of carbon atoms in the alkyl chain of polyoxyethylene alkyl ether is preferably 10 to 26, and the average number of moles of ethylene oxide added is preferably 2 to 50 moles. The number of carbon atoms in the fatty acid of polyglycerin fatty acid ester is preferably 10 to 20. The average number of moles of ethylene oxide added to polyoxyethylene / polyoxypropylene alkyl ether is preferably 10 to 300 moles, the average number of moles of propylene oxide added is preferably 5 to 70 moles, and the number of carbon atoms in the alkyl group is preferably 10 to 20. The number of carbon atoms in the alkyl group of alkyl glycoside is preferably 8 to 20. The number of carbon atoms in the fatty acid of sucrose fatty acid ester is preferably 8 to 20. The number of carbon atoms in the fatty acid of sorbitan fatty acid ester is preferably 10 to 18. The number of carbon atoms in the fatty acid of polyoxyethylene sorbitan fatty acid ester is preferably 12 to 18, and the average number of moles of ethylene oxide added is preferably 20 to 80 moles. The number of carbon atoms in the alkyl chain of the fatty acid alkylolamide is preferably 12 to 14. 【0021】 As the nonionic surfactant, polyoxyethylene hydrogenated castor oil is preferred, and polyoxyethylene hydrogenated castor oil with an average ethylene oxide addition number of 5 to 100 moles, or 5 to 60 moles, is more preferred. The nonionic surfactant may be used alone or in combination of two or more types. 【0022】Examples of anionic surfactants include alkyl sulfates, acyl amino acid salts, acyl taurine salts, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, and lauryl sulfoacetate. The alkyl and acyl groups that the anionic surfactant may have may be linear or branched, and may be saturated or unsaturated. The number of carbon atoms in the alkyl and acyl groups is preferably 8 to 20, more preferably 10 to 20, and even more preferably 10 to 18. When the anionic surfactant is a salt, it may be selected from pharmaceutically acceptable salts such as base addition salts and amino acid salts, for example, inorganic base salts such as sodium salts, potassium salts, calcium salts, magnesium salts, and ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts, and diisopropylammonium salts; and basic amino acid salts such as arginine salts. Among these, inorganic base salts are preferred, alkali metal salts (e.g., sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred. 【0023】Examples of alkyl sulfates include lauryl sulfate (dodecyl sulfate) and myristyl sulfate. As for α-olefin sulfonates, tetradecene sulfonate is preferred. Examples of acyl amino acid salts include acyl sarcosine salts such as lauroyl sarcosine salt and myristoyl sarcosine salt; acyl glutamates such as lauroyl glutamate, myristoyl glutamate, and palmitoyl glutamate; acyl glycine salts such as N-lauroyl-N-methylglycine salt and cocoyl glycine salt; acyl alanine salts such as N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl-N-methyl-β-alanine salt, and N-methyl-N-acyl alanine salt; and acyl aspartates such as lauroyl aspartate salt. Examples of acyl taurine salts include lauroyl methyl taurine salt and N-cocoyl methyl taurine salt. Other examples of anionic surfactants include hydrogenated coconut fatty acid monoglyceride monosulfate sodium, lauryl sulfoacetate sodium, and sulfosuccinates (e.g., polyoxyethylene (2) alkyl (12-14) sulfosuccinate). Anionic surfactants may be used individually or in combination of two or more. 【0024】 Examples of amphoteric surfactants include 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, alkyldimethylaminoacetic acid betaine (e.g., lauryldimethylaminoacetic acid betaine), fatty acid amidopropyl betaine (e.g., coconut oil fatty acid amidopropyl betaine), lauryl imidazolinium betaine, alkyl sulfobetaine (e.g., lauramidopropyl hydroxysultaine), and lecithin. Amphoteric surfactants may be used individually or in combination of two or more. 【0025】Examples of cationic surfactants include quaternary ammonium salt type cationic surfactants and amino acid-based cationic surfactants. Examples of quaternary ammonium salts include alkylpyridinium salts, benzethonium salts, benzalkonium salts, monoalkyltrimethylammonium salts, and dialkyldimethylammonium salts. Examples of salts include chloride salts and bromide salts. The number of carbon atoms in the alkyl and acyl groups that the cationic surfactant may have may be, for example, 8 to 22 or 9 to 21. Examples of quaternary ammonium salt type cationic surfactants include cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, behenyltrimethylammonium chloride, distearyldimethylammonium chloride, lauryldimethylbenzylammonium chloride, hexadecyltrimethylammonium bromide, and stearyltrimethylammonium bromide. Examples of amino acid-based cationic surfactants include mono-N-long-chain acyl basic amino acid lower alkyl ester salts. Examples of amino acids that may constitute a cationic surfactant include basic amino acids (e.g., natural amino acids such as ornithine, lysine, and arginine, and rigid amino acids such as α,γ-diaminobutyric acid), and may be either optically active or racemic. The acyl group that the cationic surfactant may have is preferably a saturated or unsaturated higher fatty acid residue, such as a single higher fatty acid residue like a lauroyl group, myristoyl group, palmitoyl group, or stearoyl group; or a natural mixed higher fatty acid residue like coconut oil fatty acid residues or beef tallow higher fatty acid residues. Examples of lower alkyl esters include alkyl esters having 1 to 8 carbon atoms. Specifically, examples include methyl esters, ethyl esters, propyl esters, butyl esters, pentyl esters, hexyl esters, heptyl esters, and octyl esters.Lower alkyl esters are preferably in salt form, and examples include inorganic salts such as hydrochloride, bromate, sulfate, and phosphate; and organic salts such as glycolate, acetate, lactate, succinate, tartrate, citrate, acidic amino acid salts, higher fatty acid salts, L- or DL-pyrrolidone carboxylate, pyroglutamate, and p-toluenesulfonate. Examples of amino acid-based cationic surfactants include N-coconut oil fatty acid acyl-L-arginine ethyl DL-pyrrolidone carboxylate. Cationic surfactants may be used alone or in combination of two or more. 【0026】 The surfactant may be a single type or a combination of two or more types. The surfactant preferably contains a nonionic surfactant, anionic surfactant, or amphoteric surfactant, and more preferably contains at least a nonionic surfactant. 【0027】 The surfactant content is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, and even more preferably 0.1% by mass or more. The upper limit is preferably 10% by mass or less, more preferably 5% by mass or less, and even more preferably 3% by mass or less. Therefore, it is preferably 0.001 to 10% by mass, more preferably 0.01 to 5% by mass, and even more preferably 0.1 to 3% by mass. 【0028】-Humectants- Examples of humectants include sugar alcohols and polyhydric alcohols other than sugar alcohols. Examples of sugar alcohols include sorbitol, xylitol, erythritol, maltitol, lactitol, and reduced starch syrups; glycerin; and polyhydric alcohols such as ethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, and polyethylene glycol. Examples of polyethylene glycol include polyethylene glycol with an average molecular weight of 150 to 6000, preferably polyethylene glycol with an average molecular weight of 190 to 4000. Specifically, examples include PEG200, PEG300, PEG400, PEG600, and PEG4000. The average molecular weight is the average molecular weight described in the Quasi-Drug Raw Materials Standards 2021. The humectant may be used alone or in combination of two or more types. 【0029】 The content of the wetting agent is preferably 1 to 70% by mass, more preferably 1 to 60% by mass, even more preferably 1 to 50% by mass, and even more preferably 3 to 40% by mass. 【0030】 - Binding agents (other than component (B)) - Examples of binding agents (other than component (B)) include organic binding agents and inorganic binding agents. Examples of organic binding agents include polysaccharides, cellulosic binding agents (e.g., carboxymethylcellulose (CMC) or its salts (e.g., sodium carboxymethylcellulose), hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, cationized cellulose, etc. and pharmaceutically acceptable salts thereof such as their sodium salts), other polysaccharide thickeners (other than component (B)) (e.g., guar gum, gellan gum, tragacanth gum, karaya gum, arabic gum, locust bean gum, carrageenan, sodium alginate), and synthetic water-soluble polymers (e.g., sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, polyvinyl alcohol, propylene glycol alginate). Examples of inorganic binding agents include thickening silica and aluminum silicate. Binding agents may be used individually or in combination of two or more types. 【0031】 The content of the binder (other than component (B)) is preferably 0.001% by mass or more, and more preferably 0.01% by mass or more. The upper limit is preferably 10% by mass or less, more preferably 8% by mass or less, even more preferably 5% by mass or less, and even more preferably 3% by mass or less. Therefore, it is preferably 0.001 to 10% by mass or less, more preferably 0.001 to 8% by mass, even more preferably 0.001 to 5% by mass, and even more preferably 0.01 to 3% by mass. 【0032】 -Solvent- Examples of solvents include water, lower monohydric alcohols such as ethyl alcohol (e.g., those with 1 to 4 carbon atoms), and mixed solvents thereof, but it is preferable that the solvent is substantially free of ethyl alcohol. In this specification, substantially free means a content of 10% by mass or less, preferably 8% by mass or less, more preferably 5% by mass or less, even more preferably 2% by mass or less, particularly preferably 1% by mass or less, 0.1% by mass or less, 0.01% by mass or less, 0.001% by mass or less, below the detection limit, and 0% by mass. The solvent content is preferably 50% by mass or more, more preferably 60% by mass or more, and even more preferably 70% by mass or more. There is no particular upper limit, but for example, it is 95% by mass or less and 90% by mass or less. Therefore, the solvent content is preferably 50 to 95% by mass, more preferably 60 to 95% by mass or more, and even more preferably 70 to 90% by mass. 【0033】-Fragrance- Component (E) is a fragrance. Component (C) can be used to add flavor to oral compositions. Examples of fragrances include natural oils such as peppermint oil, spearmint oil, Japanese mint oil, anise oil, cassia oil, eucalyptus oil, wintergreen oil, mastic oil, neroli oil (orange blossom oil), lemongrass oil, jasmine oil, vanilla oil, iris oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, laurel oil, chamomile oil, coriander oil, caraway oil, basil oil, marjoram oil, lemon oil, orange oil, lime oil, mandarin oil, grapefruit oil, yuzu oil, nutmeg oil, lavender oil, paracles oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, wintergreen oil, and rose oil. Essential oils; fragrance components contained in the above natural essential oils, such as carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, limonene, p-methoxycinnamic aldehyde, linalool, linalool oxide, menthone, menthyl acetate, citral, decanal, camphor, borneol, pinene, spiranthol, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, ethyl linalool, methyl jasmonate, vanillin, vanilla, germacrene, caryophyllene, viridiflorol, etc.Ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, cis-3-hexenol, trans-2-hexenal, hexyl acetate, ethyl-2-methyl butyrate, benzyl alcohol, linalyl acetate, phenylethyl glycidate, phenylethyl alcohol, allyl hexanoate, octanol, methyl cinnamate, methylheptin carbonate, ionone, ethyl-β-methylthiopropionate, cis-6-nonenol, methyl anthranilate, ethyl methylphenyl glycidate, benzaldehyde, ethyl vanillin, vanillyl butyl ether, furaneol, undecalactone, decalactone, Fragrance components such as ethylcyclopentenolone, 3-hydroxy-4,5-dimethylfuran-2-one, cyclotene, 2-methylbutyric acid, acetate acid, propionic acid, menthofran, maltol, ethylmaltol, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), 7-methyl-3,5-dihydro-2H-benzodioxepin-3-one, menthyl lactate, ethylene glycol-l-menthyl carbonate, caron, etc.; plant extracts such as chili pepper extract, ginger extract, pepper extract, Japanese pepper extract, cardamom extract, vanilla extract, etc.This also includes various blended flavors such as mint, fruit, and herb, which are created by combining several fragrance components and natural essential oils. Furthermore, fragrances that can also function as cooling agents include, for example, menthol, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), menthyl monosuccinate, menthyl glutarate, isopulegol, menthol glycoside ketal, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, 3-l-mentoxypropane-1,2-diol, 3-((-)-mentoxy)propane-1,2-diol, 5-methyl-2-propane-2-yl-N-(2-pyridine-2-ylethyl)cyclohexane-1-carboxamide, 3-(p-menthane-3carboxamide)ethyl acetate, 2-isopropyl-N,2,3-trimethylbutylamide, N-[(ethoxycarbonyl)methyl]-p-menthane-3- Other examples include carboxamide, N-p-benzene asotonitrile menthanecarboxamide, N-(2-(pyridine-2-yl)ethyl)-3-p-menthanecarboxamide, N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, 2-(4-methylphenoxy)-N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)acetamide, menthyl glyceryl ether, menthyl succinate, N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide, N-ethyl-2,2-diisopropylbutanamide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-diethylbutanamide, and N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutanamide. The fragrance may contain a solvent, such as ethanol, propylene glycol, glycerin fatty acid ester, or triacetin. Component (D) may be a single component or a combination of two or more components. 【0034】The amount of fragrance can be determined appropriately depending on the type of fragrance, but for example, it can be 0.00001% by mass or more, 0.0001% by mass or more, 0.001% by mass or more, 0.01% by mass or more, or 0.1% by mass or more, and the upper limit is 2.0% by mass or less, 1.9% by mass or less, 1.8% by mass or less, 1.7% by mass or less, 1.6% by mass or less, or 1.5% by mass or less. 【0035】 -Sweeteners- Examples of sweeteners include saccharin, sodium saccharin, aspartame, stevioside, stevia extract, neohesperidin dihydrochalcone, perillartin, thaumatin, and aspartylphenylalanine methyl ester. Sweeteners may be used individually or in combination of two or more. 【0036】- Medicinal ingredients (other than component (C)) - Medicinal ingredients include, for example, fluorides such as sodium fluoride, potassium fluoride, sodium monofluorophosphate, and tin fluoride; enzymes other than component (A) such as amylase, protease, and mutanase; anti-inflammatory agents such as allantoin, allantoin chlorohydroxyaluminum, ε-aminocaproic acid, azulene, sodium azulene sulfonate, glycyrrhizic acid or its salt (e.g., dipotassium glycyrrhizinate), glycyrrhetinic acid or its salt (e.g., stearyl glycyrrhetinate), Phellodendron bark, and Phellodendron bark extract; cell activators such as sodium chloride and vitamins; isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, thymol, lysozyme chloride, chlorhexidine, and Examples of medicinal ingredients include: bactericidal or antibacterial agents such as liclosan, zinc gluconate, and zinc citrate; water-soluble copper compounds such as copper chlorophyll and copper gluconate; tartar preventative agents such as zeolites, ethane hydroxydiphosphonate, and polyphosphates; coating agents such as hydroxyethylcellulose dimethyldiallylammonium chloride; vitamins such as vitamin C (e.g., ascorbic acid) and vitamin E (e.g., tocopherol and its derivatives); astringents such as sodium chloride, alum, and lysozyme chloride; hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, and strontium chloride; peptides such as caropeptides; fluoride compounds such as sodium fluoride, sodium monofluorophosphate, and stannous fluoride; and plant extracts such as thyme, scutellaria baicalensis, clove, and witch hazel. When an oral composition contains medicinal ingredients, the amount can be an effective amount within a range that does not hinder the effects of the present invention (a range that is pharmacologically acceptable). The medicinal ingredients may be one type alone or a combination of two or more types. 【0037】-Oily Components- Examples of oily components include hydrocarbons such as squalane, (light) liquid paraffin, petrolatum, and microcrystalline wax; higher alcohols (e.g., alcohols with 8 to 22 carbon atoms such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, and isostearyl alcohol); higher fatty acids (e.g., fatty acids with 8 to 22 carbon atoms such as lauric acid, myristic acid, oleic acid, and isostearic acid); vegetable oils such as olive oil, castor oil, and coconut oil; and fatty acid esters such as isopropyl myristate. The oily components may be used individually or in combination of two or more types. 【0038】 - Preservatives - Examples of preservatives include parahydroxybenzoic acid esters (e.g., methyl parahydroxybenzoate, ethyl parahydroxybenzoate, butyl parahydroxybenzoate), sodium benzoate, and methyl parahydroxybenzoic acid. Preservatives may be used individually or in combination of two or more. 【0039】 - pH Adjusters - Examples of pH adjusters include organic acids such as phthalic acid, citric acid, succinic acid, tartaric acid, acetic acid, fumaric acid, malic acid, and lactic acid, or their salts (e.g., sodium citrate); inorganic acids such as phosphoric acid (e.g., orthophosphoric acid), or their salts (e.g., potassium salts, sodium salts, and ammonium salts); and hydroxides such as sodium hydroxide and potassium hydroxide. Examples of inorganic salts include disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, sodium carbonate, and sodium bicarbonate. pH adjusters may be used individually or in combination of two or more. 【0040】 -Coloring Agents- As coloring agents, water-soluble dyes are preferred due to their high safety. Examples include Blue No. 1, Green No. 3, Yellow No. 4, and Red No. 105. 【0041】Examples of other optional components include inorganic compounds such as zinc oxide, magnesium oxide, and zirconium oxide; natural polymer compounds such as agar, gelatin, starch, and glucomannan; synthetic polymer compounds or their copolymers such as polyvinyl acetate, acrylic resin, polyurethane, polyester, polyvinyl chloride, nylon powder, and polyethylene powder; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, and paraffin wax; higher alcohols such as cetyl alcohol and stearyl alcohol; polyisobutylene, polybutadiene, urethane, silicon, and natural rubber. The content of these other optional components can be appropriately set within a range that does not interfere with the effects of the present invention. 【0042】 [2. Dosage form and uses of the liquid oral composition] The liquid oral composition of the present invention can take a liquid dosage form (solution, emulsion, suspension). Therefore, it can be used in the fields of quasi-drugs, foods, and cosmetics as a mouthwash, liquid dentifrice, dental rinse, etc. 【0043】 The pH (25°C) of the liquid oral composition is preferably near neutral, more preferably 5 to 9. The pH can be adjusted by adding a pH adjuster, component composition, etc. 【0044】 The viscosity at 25°C of the liquid oral composition measured with a BH viscometer is preferably 30 mPa·s or less, more preferably 0.7 to 30 mPa·s, but can be appropriately adjusted according to the use. 【0045】 The method of using the liquid oral composition may be appropriately determined according to each use. For example, methods of applying it into the oral cavity such as between teeth, gums, and tooth necks using tools such as a toothbrush, interdental brush, dental floss, non-woven fabric sheet, or finger; and methods of directly administering it from a container with a thin nozzle attached to each part of the oral cavity. Also, it may be a concentrated type product that is diluted with water or the like before use. 【0046】[3. Method for Producing Liquid Oral Composition] The method for producing a liquid oral composition is not particularly limited. For example, a method of appropriately adding and mixing raw materials and accommodating them in a container as necessary can be mentioned. The container is not particularly limited. For example, a laminated container made of a polyethylene layer, an ethylene methacrylic acid copolymer layer, a polyethylene terephthalate layer, an aluminum layer, a glass vapor deposition layer, a polyvinyl alcohol layer, an ethylene vinyl alcohol copolymer layer, an acrylonitrile copolymer layer, paper, a recycled plastic layer, etc., or a polyethylene container, a polyethylene terephthalate container, a polypropylene container, etc. can be used, and various containers commonly used as liquid oral compositions, such as a tube-shaped container, a dispenser container by mechanical or differential pressure, a film packaging container such as a pillow packaging, etc. can be used. 【0047】 Hereinafter, the present invention will be specifically described with reference to examples. The following examples are one embodiment of the present invention and do not limit the present invention. 【0048】 Examples 1 to 15 and Comparative Examples 1 to 3 [Production of Samples] The raw materials shown in Tables 1 to 3 were blended by a conventional method to obtain a mouthwash composition. The obtained mouthwash composition was evaluated by the following method. 【0049】 [Evaluation Method] (1) Clarity of Appearance Immediately after production, 80 ml of the mouthwash liquid was put into a 100 ml PET bottle, and the clarity (absence of turbidity) was determined according to the following criteria. (Evaluation Criteria) A: No turbidity is observed. B: Almost no turbidity is observed. C: Some turbidity is observed. D: Turbidity is observed. 【0050】 (2) Appearance Stability (Precipitate) 80 ml of the mouthwash liquid was put into a 100 ml PET bottle, and it was left standing and stored in a 50°C constant temperature bath. The appearance after 1 month was visually determined according to the following criteria. (Evaluation Criteria) A: No precipitate is observed. B: Almost no precipitate is observed. C: Some precipitate is observed. D: Precipitate is observed. 【0051】(3) Dextranase Stability 80 ml of mouthwash was placed in a 100 ml PET bottle and stored in a 40°C constant temperature bath for one month. This mouthwash was used as the sample solution. 1 g of each sample solution was taken and diluted 100 times with pH 7.0 phosphate buffer. Dextran was used as the substrate and reacted at 40°C for 10 minutes. The titer was measured by the ability to produce the resulting free reducing sugar, and the remaining rate was evaluated as a percentage of the initial value for each sample. (Evaluation Criteria) A: Remaining rate of 70% or more of the initial value of dextranase B: Remaining rate of 50% or more but less than 70% of the initial value of dextranase C: Remaining rate of 30% or more but less than 50% of the initial value of dextranase D: Remaining rate of less than 30% of the initial value of dextranase 【0052】 【0053】 【0054】 【0055】 [Ingredients] ・Dextranase (Mitsubishi Chemical Corporation, Dextranase) ・Xanthan gum (CP Kelco, Keldent or Keltrol CG-SFT) ・Alanine (Ajinomoto Co., Ltd., DL-Alanine) ・Glycerin (Lion Specialty Chemicals, Glycerin) ・Propylene glycol (ADEKA Corporation, Propylene glycol) ・60 mol of polyoxyethylene hydrogenated castor oil (Nikko Chemicals, NIKKOL HC O-60) ・Xylitol (Rocket Co., Ltd., Xylitol) ・Citric acid (Komatsuya Co., Ltd., Citric acid) ・Sodium citrate (Komatsuya Co., Ltd., Sodium citrate) ・Sodium benzoate (Fushimi Pharmaceutical Co., Ltd., Sodium benzoate) ・Fragrance composition A (See table below) 【0056】In Comparative Example 2, which contained component (A) but not component (B), the clarity of appearance was not a problem, similar to Comparative Example 1, which did not contain component (A). However, precipitate formation during high-temperature storage and a decrease in the activity of component (A) (dextranase) were observed. In Comparative Example 3, which contained component (A) and cellulose gum (carboxymethylcellulose sodium) instead of component (B), a decrease in clarity, precipitate formation, and a decrease in the activity of component (A) (dextranase) were observed. In contrast, in Examples 1 to 15, which contained both components (A) and (B), the clarity of appearance was good, precipitate formation during high-temperature storage was suppressed, and the activity of component (A) (dextranase) was stable. These results indicate that the oral composition of the present invention can suppress precipitate formation during high-temperature storage, maintain clarity of appearance, and improve the stability of dextranase. 【0057】 Examples of formulations of liquid oral compositions to which the present invention is applied are shown below. In formulations 1 to 8 below, the clarity of appearance was good, the formation of precipitates during high-temperature storage was suppressed, and the activity of component (A) (dextranase) was stable. In each formulation example and the fragrance formulations below, the "%" indicating the content is "mass%". 【0058】 [Formulation Example 1] Mouthwash (A) Dextranase 0.1% (B) Xanthan gum 0.02% (C) Alanine 0.3% POE hydrogenated castor oil (60) 0.3% Propylene glycol 2.5% Glycerin (85% aqueous solution) 2.5% Ethanol 4% Xylitol 3% Citric acid 0.1% Sodium citrate 0.3% Fragrance composition A 0.4% Purified water Total residue 100% 【0059】[Formulation Example 2] Mouthwash (A) Dextranase 0.1% (B) Xanthan gum 0.02% (C) Alanine 0.3% POE hydrogenated castor oil (60) 0.3% Propylene glycol 2.5% Glycerin (85% aqueous solution) 2.5% Sodium saccharin 0.005% Citric acid 0.1% Sodium citrate 0.3% Fragrance composition A 0.4% Purified water Total residue 100% 【0060】 [Formulation Example 3] Mouthwash (A) Dextranase 0.1% (B) Xanthan gum 0.02% (C) Alanine 0.3% (C) Tranexamic acid 0.1% POE hydrogenated castor oil (60) 0.3% Isopropylmethylphenol 0.1% Propylene glycol 2.5% Glycerin (85% aqueous solution) 2.5% Ethanol 4% Xylitol 3% Citric acid 0.1% Sodium citrate 0.3% Fragrance composition A 0.4% Purified water Total residue 100% 【0061】 [Formulation Example 4] Mouthwash (A) Dextranase 0.1% (B) Xanthan gum 0.02% (C) Alanine 0.3% (C) Tranexamic acid 0.1% POE hydrogenated castor oil (60) 0.3% Isopropylmethylphenol 0.1% Propylene glycol 2.5% Glycerin (85% aqueous solution) 2.5% Ethanol 4% Xylitol 3% Citric acid 0.1% Sodium citrate 0.3% Fragrance composition A 0.4% Purified water Total residue 100% 【0062】[Formulation Example 5] Mouthwash (A) Dextranase 0.1% (B) Xanthan gum 0.02% (C) Alanine 0.3% (C) Tranexamic acid 0.1% POE hydrogenated castor oil (60) 0.3% Isopropylmethylphenol 0.1% Propylene glycol 2.5% Glycerin (85% aqueous solution) 4.0% Fragrance composition A 0.4% Purified water Total residue 100% 【0063】 [Formulation Example 6] Mouthwash (A) Dextranase 0.1% (B) Xanthan gum 0.02% (C) Alanine 0.3% POE hydrogenated castor oil (60) 0.3% Propylene glycol 2.5% Glycerin (85% aqueous solution) 2.5% Sorbitol (70% aqueous solution) 5% Ethanol 4% Xylitol 3% Citric acid 0.1% Sodium citrate 0.3% Fragrance composition A 0.4% Purified water Total residue 100% 【0064】 [Formulation Example 7] Mouthwash (A) Dextranase 0.1% (B) Xanthan gum 0.02% (C) Alanine 0.3% (C) Tranexamic acid 0.1% POE hydrogenated castor oil (60) 0.3% Propylene glycol 5.0% Glycerin (85% aqueous solution) 2.5% Ethanol 4% Xylitol 3% Citric acid 0.1% Sodium citrate 0.3% Fragrance composition A 0.4% Purified water Total residue 100% 【0065】[Formulation Example 8] Mouthwash (A) Dextranase 0.1% (B) Xanthan gum 0.02% (C) Alanine 0.3% POE hydrogenated castor oil (60) 0.3% Isopropylmethylphenol 0.07% Propylene glycol 5.0% Glycerin (85% aqueous solution) 2.5% Sodium saccharin 0.005% Citric acid 0.1% Sodium citrate 0.3% Fragrance composition A 0.4% Purified water Total residue 100% 【0066】 【0067】 【0068】 【0069】 【0070】 【0071】 【0072】 【0073】 【0074】 【0075】 【0076】 【0077】 In Examples 1 to 15 and Formulation Examples 1 to 8 described above, samples with the same composition were prepared, except that fragrance compositions B to P were used instead of fragrance composition A. In all cases, the clarity of appearance was good, the formation of precipitates during high-temperature storage was suppressed, and the activity of component (A) (dextranase) was stable.

Claims

1. A liquid oral composition that is substantially free of ethyl alcohol, comprising (A) component: dextranase, and (B) component: xanthan gum.

2. The liquid oral composition according to claim 1, wherein the content of component (A) is 0.0077 to 1.54% by mass.

3. The liquid oral composition according to claim 1 or 2, wherein the content of component (B) is 0.001 to 1.0% by mass.

4. The liquid oral composition according to any one of claims 1 to 3, wherein the mass ratio ((A) / (B)) of the content of component (A) to the content of component (B) is 0.6 to 150.

5. (C) Component: A liquid oral composition according to any one of claims 1 to 4, further comprising an amino acid.

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