UV skin protection and full light repair

Abstract

Provided is a combination of at least two of creatine, bifida ferment lysate and sechium edule fruit extract to repair DNA damage to the skin caused by light in the range 280-1400 nm. These agents are combined with UV filters and optionally one or more blue light and / or one or more IR reflector(s) in cosmetic compositions used to prevent sun-induced damage to the skin, in particular to prevent senolytic or senomorphic senescence and / or appearance of the visible signs of skin aging, in particular one or more of fine lines, wrinkles, age spots, skin dryness, thinning of the skin and loss of elasticity.

Description

UV SKIN PROTECTION AND FULL LIGHT REPAIRCLAIM OF PRIORITY

[0001] This patent application claims the benefit of priority to FR Application Serial No. FR2413644, filed December 9, 2024, which is incorporated by reference herein in its entirety.TECHNICAL FIELD

[0002] The present invention is concerned with sun protection compositions that not only protect from solar radiation but also repair the residual damage that is caused by solar radiation even in the presence of a sunscreen.BACKGROUND OF THE INVENTION

[0003] The light of the sun covers the full range of frequences from UV to IR. Most of solar irradiation reaching the earth's ground has a wavelength within 280-2500nm, which covers the UV light (<380nm), visible light (380-780nm), and near-infrared (NIR) light (>780nm).

[0003] UV radiation in particular can be divided in UVA and UVB.

[0004] UVA (longer-wave) rays activate the skin in an unhealthy way until it tans, but they are not the main rays responsible for sunburn. UVA rays go far deeper into skin and trigger skin cancer and premature ageing damage.

[0005] UVB (shorter-wave) rays are responsible for causing sunburn and trigger premature ageing damage. It’s mostly absorbed by the top layers of the skin and is considered the common cause of most skin cancers. Although shorter in length than UVA rays, UVB rays are more intense, especially during peak hours.

[0006] Photoaging describes all the pro-ageing skin damage (wrinkles, fine lines, uneven tone, dark spots) that the sun and light can cause. Photoaging is accrued throughout life.

[0007] Although UV rays are major contributors, they’re not the only forms of light that can cause photoaging. High-energy visible light, otherwise known as HEV light, and infrared light (which we feel as heat) also add to the skin damage pot that is photoaging.

[0008] Important consequences of exposure to sunlight are skin aging and skin cellular senescence.

[0009] Skin aging refers to the gradual deterioration of skin structure and function over time. It results from a combination of intrinsic factors (genetics, hormonal changes, and metabolic processes) and extrinsic factors (UV radiation, pollution, smoking, and lifestyle). Theseinfluences lead to visible changes such as wrinkles, dryness, thinning, loss of elasticity, and uneven pigmentation. Skin aging is a complex, multifactorial process affecting all layers of the skin — the epidermis, dermis, and subcutaneous tissue.

[0010] Skin senescence, on the other hand, refers to a cellular-level phenomenon in which skin cells enter a permanent state of growth arrest, called cellular senescence, without undergoing cell death. Senescent cells remain metabolically active but secrete inflammatory cytokines, enzymes, and growth factors known collectively as the senescence-associated secretory phenotype (SASP). These factors can disrupt tissue structure, promote chronic inflammation, and affect nearby healthy cells.

[0011] While skin aging describes the overall process and appearance of aging skin, skin senescence is one of its key biological drivers. In short, senescence occurs at the microscopic, cellular level and contributes to the macroscopic signs of aging skin — but aging itself encompasses a wider range of molecular, cellular, and environmental changes beyond senescence alone.

[0012] Cosmetic compositions comprising mixtures of organic and inorganic UV filters have long been on the market. Commonly sold as sunscreens, sunblocks, sun lotions or sun creams, they are photoprotective topical products for the skin that helps protect against sunburn and prevent skin cancer. Sunscreens come as lotions, sprays, gels, foams, sticks, powders and other topical products.

[0013] SPF (Sun Protection Factor) is a measure of how much solar energy (UV radiation) is required to produce sunburn on protected skin (i.e., in the presence of sunscreen) relative to the amount of solar energy required to produce sunburn on unprotected skin. As the SPF value increases, sunburn protection increases.

[0014] Creatine (INCI: Creatine) is naturally produced by the amino acids of the body.

[0015] Bifida ferment lysate (INCI: Bifida Ferment Lysate) is a postbiotic fraction ingredient. As it is inter alia a commercially available product, at least one enabling method of extraction is known in the art.

[0016] Sechium edule fruit extract (INCI: Sechium Edule Fruit Extract) is an extract of the fruit of sechium edule, Cucurbitaceae. As it is inter alia a commercially available (see e.g. CAS 223748-59-2) product, at least one enabling method of extraction is known in the art.

[0017] Reflectors are active ingredients that reduce the amount of UV, visible including blue light and / or infrared rays received by the skin. They do not provide a sun protection factor (SPF) value of 2 or higher.

[0018] The Radical Protection Factor (RPF) for cosmetics is a unit for the determination of the radical scavenging activity of antioxidant products.

[0019] There remains a need for sun protection compositions that not only protect from solar radiation but also repair the damage that is caused by solar radiation even in the presence of a sunscreen.

[0020] There is further an unmet need to provide a full-light (i.e. in the range 280-1400 nm) protection formula having haptic properties that meet consumer demand even in the presence of an important oil phase.SUMMARY OF THE INVENTION

[0021] This summary is provided to introduce a selection of concepts in a simplified form that are further described below in the detailed description. This summary is not intended to identify required or essential features of the claimed subject matter. Nor is this summary intended to be used to limit the scope of the claimed subject matter.

[0022] The present inventors have surprisingly found that a combination of at least two of creatine (in particular INCI: Creatine), bifida ferment lysate (in particular INCI: Bifida Ferment Lysate) and sechium edule fruit extract (in particular INCI: Sechium Edule Fruit Extract) repairs DNA damage to the skin caused by light in the range 280-1400 nm (hereafter full-light protection), and may be combined with UV filters and optionally one or more blue light and / or one or more IR reflector(s) to provide a simultaneous sunlight damage protection and repair benefit, in particular in the full spectrum from UVB to IR, i.e. in the range of 280 - 1400 nm. The combined agents may act synergistically.

[0023] An object of the present invention is therefore a cosmetic composition comprising;A. A sunlight protecting component comprising i. one or more UVA filter(s), one or more UVB filter(s) and / or one or more UVA / UVB filter(s); ii. one or more anti oxi dant(s); and iii. optionally one or more blue light and / or one or more IR reflector(s); andB. A full-light skin repair component comprising at least two of the following: iv. creatine; v. bifida ferment lysate; and / or vi. Sechium Edule Fruit Extract.

[0024] A further object of the present invention is the cosmetic or medical use of a full -light skin repair composition comprising at least two of the following: iv. creatine; v. bifida ferment lysate; and / or vi . S echium Edul e Fruit Extract to repair the skin damage caused by solar radiation, in particular the skin damage (DNA), even in the presence of a sunlight protecting composition.

[0025] A further object of the present invention is a cosmetic or medical method to repair the skin damage caused by solar radiation, in particular the DNA skin damage, even in the presence of a sunlight protecting composition, the method comprising administering to the skin in a way known to the skilled person of a full-light skin repair composition comprising at least two of the following: iv. creatine; v. bifida ferment lysate; and / or vi. Sechium Edule Fruit Extract.

[0026] Further objects of the present invention are presented in the appended claims.

[0027] Both the foregoing summary and the following detailed description provide examples and are explanatory only. Accordingly, the foregoing summary and the following detailed description should not be considered to be restrictive. Further, features or variations may be provided in addition to those set forth herein. For example, certain aspects may be directed to various feature combinations and sub-combinations described in the detailed description.DEFINITIONS

[0028] Throughout this document, values expressed in a range format should be interpreted in a flexible manner to include not only the numerical values explicitly recited as the limits of the range, but also to include all the individual numerical values or sub-ranges encompassedwithin that range as if each numerical value and sub-range is explicitly recited. For example, a range of “about 0.1% to about 5%” or “about 0.1% to 5%” should be interpreted to include not just about 0.1% to about 5%, but also the individual values (e.g., 1%, 2%, 3%, and 4%) and the sub-ranges (e.g., 0.1% to 0.5%, 1.1% to 2.2%, 3.3% to 4.4%) within the indicated range. The statement “about X to Y” has the same meaning as “about X to about Y,” unless indicated otherwise. Likewise, the statement “about X, Y, or about Z” has the same meaning as “about X, about Y, or about Z,” unless indicated otherwise.

[0029] In this document, the terms “a,” “an,” or “the” are used to include one or more than one unless the context clearly dictates otherwise. The term “or” is used to refer to a nonexclusive “or” unless otherwise indicated. The statement “at least one of A and B” or “at least one of A or B” has the same meaning as “A, B, or A and B .” In addition, it is to be understood that the phraseology or terminology employed herein, and not otherwise defined, is for the purpose of description only and not of limitation.

[0030] All publications, patents, and patent documents referred to in this document are incorporated by reference herein in their entirety, as though individually incorporated by reference. In the event of inconsistent usages between this document and those documents so incorporated by reference, the usage in the incorporated reference should be considered supplementary to that of this document; for irreconcilable inconsistencies, the usage in this document controls.

[0031] The term “about” as used herein can allow for a degree of variability in a value or range, for example, within 10%, within 5%, or within 1% of a stated value or of a stated limit of a range and includes the exact stated value or range. The term “substantially” as used herein refers to a majority of, or mostly, as in at least about 50%, 60%, 70%, 80%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5%, 99.9%, 99.99%, or at least about 99.999% or more, or 100%.

[0032] The term “substantially free of’ as used herein can mean having none or having a trivial amount of, such that the amount of material present does not affect the material properties of the composition including the material, such that about 0 wt% to about 5 wt% of the composition is the material, or about 0 wt% to about 1 wt%, or about 5 wt% or less, or less than or equal to about 4.5 wt%, 4, 3.5, 3, 2.5, 2, 1.5, 1, 0.9, 0.8, 0.7, 0.6, 0.5, 0.4, 0.3, 0.2, 0.1, 0.01, or about 0.001 wt% or less, or about 0 wt%.

[0033] When percentages of ingredients in compositions are indicated, the standard error applies. For example, 3.0% is to be interpreted as 2.9% to 3.1%

[0034] The term “ comprise .s” and variations thereof is to be interpreted as meaning both “includes” , “substantially consists of and “consists of, and variations thereof.

[0035] When different embodiments are herein described that further specify different features of the present invention it is intended that these embodiments can be combined in a further embodiment specifying two or more features of the present invention even when such combined embodiment is not explicitly described herein.

[0036] When the quantity of an ingredient of a composition is indicated as % or wt% it is intended over the total weight of the composition, unless otherwise indicated.

[0037] If any given chemical entity is generally known in the art to belong to two or more cosmetic functional classes (is for example known to be both a film former and an emollient) and those functional classes are part of the definition of the claimed subject matter, that chemical entity may be present only once in any embodiment of the claimed invention, i.e. it can belong to only one of those two or more functional classes.DETAILED DESCRIPTION OF THE INVENTION

[0038] The present inventors have surprisingly found that a combination of at least two of creatine (in particular INCI: Creatine), bifida ferment lysate (in particular INCI: Bifida Ferment Lysate) and sechium edule fruit extract (in particular INCI: Sechium Edule Fruit Extract) effectively repairs damage to the skin caused by radiation in the range 280-1400 nm, and may be combined with UV protective agents to provide a simultaneous sunlight damage protection and repair benefit, in particular in the full sun spectrum from UVB to IR, i.e. in the range of 280 -1400 nm.

[0039] An object of the present invention is therefore a cosmetic composition comprising;A. A sunlight protecting component comprising i. one or more UVA filter(s), one or more UVB filter(s) and / or one or more UVA / UVB filter(s); ii. one or more anti oxi dant(s); and iii. optionally one or more blue light and / or one or more IR reflector(s); andB. A full-light skin repair component comprising at least two of the following: iv. creatine; v. bifida ferment lysate; and / orvi. Sechium Edule Fruit Extract.

[0040] Preferably, the repair component is one of the following combinations:(iv) and (v);(iv) and (vi);(v) and (vi);(iv) and (v) and (vi).

[0041] The quantity of creatine in the compositions of the invention is typically in the range of about 0.005% to about 10% of the total weight of the composition (% wt). All values between the limits of these ranges are hereby explicitly disclosed.

[0042] The quantity of bifida ferment lysate in the compositions of the invention is typically in the range of about 0.00005% to about 5% of the total weight of the composition (% wt). All values between the limits of these ranges are hereby explicitly disclosed.

[0043] The quantity of Sechium edule fruit extract in the compositions of the invention is typically in the range of about 0.00015% to about 1% of the total weight of the composition (% wt). All values between the limits of these ranges are hereby explicitly disclosed.

[0044] At least two of creatine, bifida ferment extract and Sechium Edule Fruit Extract are present in the compositions of the present invention. The two or all of creatine, bifida ferment extract and Sechium Edule Fruit Extract present in the compositions of the present invention may act synergistically to provide repair.

[0045] Without being bound by theory it is believed that the repair derives from the repair action of bifida ferment extract against damage caused by UVB radiation and the repair action of Sechium Edule Fruit Extract against damage caused by UVA radiation, both further supported by the energy booster action exerted by creatine. The inventors have further found that Sechium Edule Fruit Extract helps repair also damage caused by UVB and blue light, beyond what known in the art.

[0046] The protecting component of the compositions according to the invention comprises one or more UVA filter(s), one or more UVB filter(s) and / or one or more UVA / UVB filter(s).

[0047] Sunscreen filters that may be present in a composition of the present invention may be:A. Screens, which use only inorganic compounds (mainly zinc oxide and / or titanium dioxide) as active ingredients. These ingredients primarily work by absorbing UV rays but also through reflection and refraction; andB. Chemical sunscreens, which use organic molecules as active ingredients; and / orC. Mixtures thereof.

[0048] By way of illustration of organic UV filters that may be present in a composition of the present invention, and in a non-limiting manner, mention may be made of: anthranilates, in particular menthyl anthranilate; benzophenones, in particular 1 -benzophenone, 3 -benzophenone or oxybenzone, 5- benzophenone, 6-benzophenone, 8 -benzophenone, 9-benzophenone, 12-benzophenone, and preferably 2-benzophenone (Oxybenzone), or 4-benzophenone (Uvinul MS40® available from B.A.S.F.); benzylidenecamphor, in particular 3 -benzylidenecamphor, benzylidenecamphorsulphonic acid, benzalkoniumcamphor methosulfate, polyacrylamidomethylbenzylidenecamphor, terephthalylidenecamphorsulphonic acid, and preferably 4-methylbenzylidenecamphor (Eusolex 6300® available from Merck); benzimidazoles, in particular benzimidazilate (Neo Heliopan AP® available from Haarmann and Reimer), or phenylbenzimidazole sulfonic acid (PARSOL HS® available from DSM); benzotriazoles, in particular drometrizole trisiloxane, or methylene bis- benzotriazolyltetramethylbutylphenol (Tinosorb M® available from Ciba); cinnamates, in particular cinoxate, DEA methoxy cinnamate, diisopropyl methylcinnamate, dimethoxycinnamate glyceryl ethyl hexanoate, isopropyl methoxycinnamate, isoamyl cinnamate, Kaempferia galanga root extract (TEGO GALANGA from EVONIK containing 98% ethyl-p-methoxy cinnamate) and preferably octylmethoxy cinnamate (Parsol MCX® available from Hoffmann La Roche); diphenylacrylates, in particular ethocrylene (Uvinul N35® available from B.A.S.F.), or octocrylene (Uvinul 539® available from B.A.S.F.) or Ethylhexyl methoxycrylene (SOLASTAY available from HALLSTAR);dibenzoylmethanes, in particular butyl methoxy dibenzoylmethane (Parsol 1789®); imidazolines, in particular ethylhexyl dimethoxybenzylidenedioxoimidazoline;PABA, in particular ethyl dihydroxypropyl PABA, ethylhexyl dimethyl PABA, glyceryl PABA, PABA, PEG-25 PABA, or ethyl PABA (benzocaine); triazines, in particular anisotriazine (Tinosorb S® available from Ciba) or diethylhexylbutamido-triazone (Uvasorb HEB® available from 3 V Sigma), ethylhexyltriazone (Uvinul T150® available from B. A. S. F.), Tris-Biphenyl Triazine (Tinosorb A2B available from BASF), benzoates, in particular N-hexyl 2-(4-diethylamino-2- hydroxybenzoyl)benzoate (Uvinul A+ available from BASF) or as a mixture with octyl methoxy cinnamate (Uvinul A+B available from BASF), benzalmalonates, in particular Poly silicone- 15 (Parsol SLX available from DSM), benzoxazoles, in particular 2, 4-bis[4-[5-(l .1 -dimethylpropyl)benzoxazol-2- yl]phenylimino]-6-[(2-ethylhexyl)imino]-l .3, 5 -tri azine, (Uvasorb K2A available from Sigma 3 V); salicylates, in particular dipropylene glycol salicyclate, ethylhexyl salicylate, homosalate, butyloctyl salicylate (HALLBRITE BHB available from HALLSTAR or TEA salicylate;Phenylbenzimidazole sulfonic acid (eg Parsol HS), Octocrylene (eg Parsol 340), Ethylhexyl Methoxy cinnamate (eg Parsol MCX), Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (eg Tinosorb M), Bi s-Ethylhexyl oxyphenol Methoxyphenyl Triazine (eg Tinosorb S), Tris-Biphenyl Triazine (eg Tinosorb A2B), Ethylhexyl Triazone (eg UVINUL T150) and Di ethylhexyl Butamido Triazone (eg UVASORB HEB), Diethylamino Hydroxybenzoyl Hexyl Benzoate (eg Uvinul A PLUS), Butyl Methoxy dibenzoylmethane (eg Parsol 1789), Poly silicone- 15 (eg Parsol SLX), Benzophenone-4 (eg Uvinul MS 40), Benzophenone-3, Ethylhexyl Salicylate (eg Parsol EHS), Homosalate; and / or mixtures thereof.

[0049] In a preferred embodiment the sunlight protecting component of the cosmetic compositions according to the invention comprises a mixture of BISETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE (BEMT) and DIETHYLHEXYL BUTAMIDO TRIAZONE (DHBT).

[0050] In a further preferred embodiment, it may additionally comprise at least two of ETHYLHEXYL TRIAZONE (EHT), HOMOSALATE and / or BUTYL METHOXYDIBENZOYLMETHANE.

[0051] In a further preferred embodiment it may further additionally comprise PHENYLBENZIMIDAZOLE SULFONIC ACID (also together with OCTYL SALICYLATE) and / or DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE.

[0052] The inorganic UV screening agents used are metal oxide particles having an average elementary particle size between about 5 and about 600 nm. In particular embodiments the particle size is 15, 30, 50, 100, 150, 200, 250, 300, 350, 400, 450, 500, 550 nm. They may be chosen in particular from titanium oxide, zinc oxide, iron oxide, zirconium oxide, cerium oxide, and mixtures thereof.

[0053] The titanium oxides may be in a crystallized form of the rutile and / or anatase type, and / or in an amorphous or substantially amorphous form. Such coated or uncoated metal oxide pigments are described in particular in patent application EP-A-0, 518,773. As commercial pigments, mention may be made of the products sold by the companies Kemira, Tayca, Merck and Degussa.

[0054] The metal oxide pigments may be coated or uncoated.

[0055] The coated pigments are pigments which have undergone one or more surface treatments of chemical, electronic, mechanochemical and / or mechanical nature with compounds such as amino acids, beeswax, fatty acids, fatty alcohols, anionic surfactants, lecithin, sodium, potassium, zinc, iron or aluminum salts of fatty acids, metal (titanium or aluminum) alkoxides, polyethylene, silicones, proteins (collagen, elastin), alkanolamines, silicon oxides, metal oxides or hexametaphosphate of fatty acids .

[0056] Examples of coated titanium oxide pigments are: silica (SUNVEIL from IKEDA), silica and iron oxide (SUNVEIL F from IKEDA), silica and polyglyceryl- 10 stearate (COSMESERVE WP-40W from IWASE COSFA), silica and alumina (MICROTITANIUM DIOXIDE MT500 SA and MICROTITANIUM DIOXIDE MT 100 SA from TAYCA, TIOVEIL from TIOXIDE), alumina (TIPAQUE TTO-55 (B) and TIPAQUE TTO-55 (A) from ISHIHARA, and UVT 14 / 4 from KEMIRA), Rutile TiO2 treated with alumina and glycerol-coated silica (UV TITAN M212 from KEMIRA), Rutile TiO2 treated with alumina and dimethicone (UV TITAN M195 from KEMIRA), Alumina and aluminum stearate (Microtitanium Dioxide MT 100 T, MT 100 TV, MT 100 TX, MT 100 Z,MT-01 from TAYCA, Solaveil CT-10 W and Solaveil CT 100 from UNIQEMA and Eusolex T-AVO from MERCK), silica, alumina and alginic acid (MT-100 AQ from TAYCA), alumina and aluminum laurate (TAYCA MICROTITANIUM DIOXIDE MT 100 S), alumina, methicone and polyhydroxystearic acid (INP60T7 from KOBO), iron oxide and iron stearate (TAYCA MICROTITANIUM DIOXIDE MT 100 F), zinc oxide and zinc stearate (TAYCA BR 351), silica and alumina and treated with silicone (MICROTITANIUM DIOXIDE MT 600SAS, MICROTITANIUM DIOXIDE MT 500 SAS or MICROTITANIUM DIOXIDE MT 100 SAS from TAYCA), silica, alumina, aluminum stearate and treated with a silicone (STT- 30-DS from TITAN KOGYO), alumina and treated with a silicone (TIPAQUE TTO-55 (S) from ISHIHARA, or UV TITAN M 262 from KEMIRA), triethanolamine (STT-65-S from TITAN KOGYO); stearic acid (TIPAQUE TTO-55 (C) from ISHIHARA, strearic acid (and) aluminium hydroxide (MPT-186 SAKAI) or isostearic acid (MioShade T-Plus Natural Mioshy)) sodium hexametaphosphate (MICROTITANIUM DIOXIDE MT 150 W TAYCA)TiO2 treated with octyl trimethyl silane (T 805 by the company DEGUSSA SILICES);TiO2 treated with a poly dimethylsiloxane (70250 UF TiO2S13 framework per framework); anatase / rutile TiO2 treated with a polydimethylhydrogenosiloxane (MICRO TITANIUM DIOXIDE USP GRADE HYDROPHOBIC by COLOR TECHNIQUES),Rutile TiO2 treated with alumina, stearic acid (UV TITAN M160 by KEMIRA),TiO2 treated with alumina hydroxide, stearic acid and triethoxycaprylylsilane (ALT- T-400 by MAPRECOS)or alumina hydroxide, stearic acid (and) dimethicone (Mioshade T- clear Mioshi), or alumina and hydrogen dimethicone (TTO-MS4 KOBO): or manganese-doped TiO2 (Croda OPT 1 -PW); and / or their mixtures.

[0057] Examples of uncoated titanium oxide pigments are:MICROTITANIUM DIOXIDE MT 500 B or MICROTITANIUM DIOXIDE MT600 B by TAYCA;P 25 by DEGUSSA;Transparent titanium oxide PW by WACKER;UFTR by MI YO SHI K ASEI;ITS by TOMEN;TIOVEIL AQ by the company TIOXIDE and / or their mixtures.

[0058] Examples of uncoated zinc oxide pigments are:Z-cote by Sunsmart;Nanox by Element! s;Nanogard WCD 2025 by Nanophase Technologies and / or their mixtures.

[0059] Coated zinc oxide pigments are, for example: zinc oxide CS-5 by Toshibi (ZnO coated with polymethylhydrogenesiloxane);Nanogard Zinc Oxide FN by Nanophase Technologies (40% dispersion in Finsolv TN, C12-C15 alcohol benzoate);DAITOPERSION ZN-30 and DAITOPERSION Zn-50 by the company Daito (dispersions in cyclopolymethylsiloxane / oxyethylenated polydimethylsiloxane, containing 30% or 50% of zinc nano-oxides coated with silica and polymethylhydrogenenesiloxane);NFD Ultrafine ZnO by Daikin (ZnO coated with perfluoroalkyl phosphate and perfluoroalkylethyl copolymer in dispersion in cyclopentasiloxane);SPD-Z1 by Shin-Etsu (ZnO coated with silicone grafted acrylic polymer, dispersed in cyclodimethyl siloxane);Escalol Z 100 by the company ISP (ZnO treated with alumina and dispersed in the mixture of ethylhexyl methoxycinnamate / PVP-hexadecene / methicone copolymer);Fuji ZnO-SMS-10 by Fuji Pigment (ZnO coated silica and poly m ethyl sil se squi oxane) ;Nanox Gel TN by the company Elementis (ZnO dispersed at 55% in C12-C15 alcohol benzoate with hydroxystearic acid polycondensate);OTS-5 MZ-500 by DAITO (ZnO dispersed in triethoxycaprylylsilane);natural coatings for example jojoba esters (ZnO-750-NJE7 KOBO) Hydrogenated Olive Oil Stearyl Esters (MZO-35-NOE7 KOBO) and / or their mixtures.

[0060] The uncoated cerium oxide pigments may be, for example, those sold under the name Colloidal Cerium Oxide by the company Rhone Poulenc.

[0061] Preferably, the zinc and titanium filters are coated. Most preferably they are Zinc Oxide (and) Triethoxycaprylylsilane (INCI) and / or Titanium dioxide (And) Aluminum hydroxide (And) Aluminum stearate (INCI). In another embodiment they are Zinc Oxide (and) Triethoxycaprylylsilane (and) Ethyl Ferulate (INCI), Zinc Oxide (And) Stearoyl Glutamic Acid (INCI) or Titanium Dioxide (and) Isostearic Acid (INCI)

[0062] If they are both present the ratio depends on the target SPF: for example, for SPF 50 they are present at a ratio ZnO:TiO2 between 3 : 1 and 4: 1.

[0063] In addition, the protecting component of the compositions according to the invention comprises an antioxidant system. In one embodiment the antioxidant system comprises at least one full light antioxidant and at least one blue light antioxidant.

[0064] In one embodiment the full light antioxidant is one or more of all biotechnological agents, all agents protecting nucleus, cytosol, mitochondria and any other cell organites from oxidative stress, resveratrol and derivates like pterostilbene and derivates, carnosine, dimethyl methoxy chromanol and more generally all chromanols and derivates, budjella officinalis extract including flower extract, glutathione and derivates, vitamin C and derivates, Vitamin E and derivates, vitamin A and derivates, Vitamins B and derivates and in particular Vitamin B3 and derivates, physalis angulata extract, n acetyl neuraminic acid and derivates, coenzyme Q10 and derivates, red salvia extracts and combinations, cryptotanshinone and derivates, all catechines and derivates, all carotenoides and derivates including beta carotene, asthaxanthin, all xanthin and derivates, xanthophil molecules, pterostillbene and derivates, all terpenes, quercetin, curcumin, melatonin, kaempferol, myricetin, Scutellaria baicanlensis and more generally all extracts or molecules rich in baicalin and / or baicalein, curcuma and compositions with it and derivates, all tea extracts, gingko extract, all vitis vinifera and derivates, all terminalia extracts including Terminalia Ferdinandiana Fruit Extract , all extracts rich in Vitamin C in general, all extracts or oils rich in vitamin E in general like argan oil, all sterols and derivates, all polyphenols and derivates, all flavonoids and derivates including prenylated flavonoids, any polygonum extract including Polygonum Aviculare Extract and any extractfrom Polygonum Cuspidatum , any extract or combination comprising Caesalpinia Spinosa Fruit Pod Extract and Helianthus Annuus (Sunflower) Sprout Extract , all polyphenols and derivates, MAA mimicking agents, and combinations thereof.

[0065] The antioxidant system comprises preferably at least one full light antioxidant and at least one blue light antioxidant.

[0066] In one embodiment the full light antioxidant is one or more of dimethylmethoxy chromanol (lipochroman), a chromane derivate, vitamin C and its derivates, Vitamin E and its derivates, polyphenols, carnosine, pterostilbene and / or resveratrol and derivatives thereof.

[0067] In another or the same embodiment the blue light antioxidant is one or more of niacinamide, butterfly bush extract, dimethyl methoxy chromanol, vit C and derivates and / or cocoa extract.

[0068] In one further embodiment the antioxidant is a mixture of dimethylmethoxy chromanol (lipochroman) and Buddleja Officinalis Flower Extract.

[0069] In one further embodiment the antioxidant is dimethylmethoxy chromanol (lipochroman).

[0070] Optionally the compositions according to the present invention comprise one or more blue light and / or one or more IR radiation reflectors.

[0071] In general, reflectors are active ingredients that reduce the amount of radiation received by the skin without providing a sun protection factor (SPF) value of 2 or higher.

[0072] Reflectors are based on flake-form, transparent or semitransparent substrates comprising, for example, phyllosilicates, such as, for example, natural mica, synthetic mica, talc, sericite, kaolin, aluminium oxide, silicon dioxide, glass or other silicate materials, which are coated with coloured or colourless metal oxides, such as, for example, TiO2, titanium suboxides, titanium oxynitrides, Fe2O3, Fe3O4, SnO2, Cr2O3, ZnO, CuO, NiO and other metal oxides, alone or in a mixture in a uniform layer or in successive layers.

[0073] Preferably the blue light and / or IR radiation reflector is an interference pigment, more preferably those known under the brand names Timiron®, Ronastar®, Xirona®, Colorona®, Dichrona®, most preferably Timiron® or Ronastar®.

[0074] Timiron® denotes a series of silver-white pigments characterized by variable titanium dioxide layers on natural or synthetic mica or aluminum oxide platelets. They vary in particle size distribution, ranging from 1 - 15 pm to 20 - 180 pm. Depending on their particlesize and pigment composition, they display different silverwhite lustrous effects ranging from subtle to satiny, pearly, metallic, or even sparkly.

[0075] Ronastar® denotes a series of silverwhite pigments based on Calcium Aluminum Borosilicate flakes. They vary in particle size distribution (10 - 100 pm and 20 - 200 pm) and display brilliant silverwhite effects combined with rainbow-like multicolor highlights.

[0076] Most preferably the blue light and / or IR radiation reflector is Timiron Starlust MP115 (INCI: Mica (CI 77019) (and) Titanium Dioxide (CI 77891)).

[0077] Formulas with high SPF must contain large amounts of UV filters in order to offer the claimed protection. These filters need to be solubilized, which requires a large amount of oil phase. Already this results in a shining formula, and the addition of the usual amounts of interference pigments like Timiron Starlust MP115 exacerbates further what is perceived by consumers as an undesirable property.

[0078] By carefully balancing the amount of light blue light and / or IR reflector the resulting formula has acceptable haptic properties without losing in protection.

[0079] The cosmetic composition according to the present invention optionally comprises a blue light absorber.

[0080] Examples of blue light absorbers that can be used in the present invention are pigments, carotenoids, Annatto, Lutheine, Astaxanthine, baicalin and / or bacalein.

[0081] In a preferred embodiment of the present invention the blue light absorber and the antioxidant are not the same compound.

[0082] The cosmetic composition according to the present invention can be in the form of a topical formulation, in particular in the form of an oil-in-water emulsion, a water-in-oil emulsion, a multiple emulsion (Water / Oil / Water or Oil / Water / Oil), a microemulsion, a nanoemulsion, a solution, a suspension, a hydrodispersion, a gel, an ointment, a paste, an aerosol foam, a spray, an aqueous gel, a powder, a foundation, a transdermal patch, a cream or a mask.

[0083] The composition can also be suitable for enteral or parenteral administration, in particular intradermal or subcutaneous administration.

[0084] The topical compositions according to the invention may comprise at least one further ingredient commonly found in topical cosmetic and / or medical (e.g. dermatological) compositions chosen from water, oils, which may be chosen in particular from volatile and / ornon-volatile, linear or cyclic silicone oils, waxes (such as ozokerite, polyethylene wax, beeswax or carnauba wax), silicone elastomers, nonionic, anionic, cationic and / or amphoteric surfactants, co-surfactant (such as linear fatty alcohols), thickeners, gelling agents, humectants (such as polyols like glycerin), colorants, preservatives, fillers, tensors, sequestrants, perfumes, and mixtures hereof.

[0085] These compositions can be in particular in the form of oil-in-water emulsions, water- in-oil emulsions, Silicone / water emulsions, Water / Silicone emulsions, multiple emulsions (Water / Oil / Water or Oil / Water / Oil) which can optionally be microemulsions or nanoemulsions, or in the form of solutions, suspensions, hydrodispersions, oils, gels, ointments, pastes, aerosol foams or sprays, aqueous gels, powders, or foundations or transdermal patches. They can be more or less fluid and have the appearance of creams, emulsions, gels, masks or any other aspect of healthy skin care cosmetics. The person skilled in the art is aware of the procedures, ingredients and forms of common use in the preparation of dermal formulations.

[0086] A “gel” is a colloid in which the dispersed phase has combined with the continuous phase to produce a semisolid material, such as jelly.

[0087] An “oil” is a composition containing at least 95% wt of a lipophilic substance. Examples of lipophilic substances include but are not limited to naturally occurring and synthetic oils, fats, fatty acids, lecithins, triglycerides and combinations thereof.

[0088] A “continuous phase” refers to the liquid in which solids are suspended or droplets of another liquid are dispersed and is sometimes called the external phase. This also refers to the fluid phase of a colloid within which solid or fluid particles are distributed. If the continuous phase is water (or another hydrophilic solvent), water-soluble or hydrophilic drugs will dissolve in the continuous phase (as opposed to being dispersed). In a multiphase formulation (e.g., an emulsion), the discreet phase is suspended or dispersed in the continuous phase. Excipients for topical administration may include anti -microbial compounds, e.g. parabens, antioxidants, e.g. sodium ascorbyl acetate and alpha-tocopherol, stabilizers, e.g. sorbitol, and / or emulsifying agents to produce a stable emulsion with both a hydrophilic and a hydrophobic phase.

[0089] “Diluents” may be included in the formulations to dissolve, disperse or otherwise incorporate the carrier. Examples of diluents include, but are not limited to, water, buffered aqueous solutions, organic hydrophilic diluents, such as monovalent alcohols, and lowmolecular weight glycols and polyols (e.g. propylene glycol, polypropylene glycol, glycerol, butylene glycol).

[0090] Appropriate excipients are selected based on the type of formulation. Standard excipients include gelatin, casein, lecithin, gum acacia, cholesterol, tragacanth, stearic acid, benzalkonium chloride, calcium stearate, glyceryl monostearate, cetostearyl alcohol, cetomacrogol emulsifying wax, sorbitan esters, polyoxyethylene alkyl ethers, polyoxyethylene castor oil derivatives, polyoxyethylene sorbitan fatty acid esters, polyethylene glycols, polyoxyethylene stearates, colloidol silicon dioxide, phosphates, sodium dodecyl sulfate, carboxymethylcellulose calcium, carboxymethylcellulose sodium, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethycellulose phthalate, noncrystalline cellulose, magnesium aluminum silicate, triethanolamine, polyvinyl alcohol, polyvinylpyrrolidone, sugars, and starches.

[0091] An emulsion is a preparation of one liquid distributed in small globules throughout the body of a second liquid. The dispersed liquid is the discontinuous phase, and the dispersion medium is the continuous phase. When oil is the dispersed liquid and an aqueous solution is the continuous phase, it is known as an oil-in-water emulsion, whereas when water or aqueous solution is the dispersed phase and oil or oleaginous substance is the continuous phase, it is known as a water-in-oil emulsion. The oil phase may consist at least in part of a propellant, such as an HFA propellant. Either or both of the oil phase and the aqueous phase may contain one or more surfactants, emulsifiers, emulsion stabilizers, buffers, and other excipients. Preferred excipients include surfactants, especially non-ionic surfactants; emulsifying agents, especially emulsifying waxes; and liquid non-volatile non-aqueous materials, particularly glycols such as propylene glycol. The oil phase may contain other oily pharmaceutically approved excipients. For example, materials such as hydroxylated castor oil or sesame oil may be used in the oil phase as surfactants or emulsifiers.

[0092] “Emollients” are an externally applied agent that softens or soothes skin and are generally known in the art and listed in compendia, such as the “Handbook of Pharmaceutical Excipients”, 4th Ed., Pharmaceutical Press, 2003. These include, without limitation, almond oil, castor oil, ceratonia extract, cetostearoyl alcohol, cetyl alcohol, cetyl esters wax, cholesterol, cottonseed oil, cyclomethicone, ethylene glycol palmitostearate, glycerin, glycerin monostearate, glyceryl monooleate, isopropyl myristate, isopropyl palmitate, lanolin, lecithin, light mineral oil, medium-chain triglycerides, mineral oil and lanolin alcohols, petrolatum, petrolatum and lanolin alcohols, soybean oil, starch, stearyl alcohol, sunflower oil, xylitol andcombinations thereof. In one embodiment, the emollients are ethylhexyl stearate and ethylhexyl palmitate.

[0093] “Surfactants” are surface-active agents that lower surface tension and thereby increase the emulsifying, foaming, dispersing, spreading and wetting properties of a product. Suitable non-ionic surfactants include emulsifying wax, glyceryl monooleate, polyoxyethylene alkyl ethers, polyoxyethylene castor oil derivatives, polysorbate, sorbitan esters, benzyl alcohol, benzyl benzoate, cyclodextrins, glycerin monostearate, poloxamer, povidone and combinations thereof. In one embodiment, the non-ionic surfactant is stearyl alcohol.

[0094] “Emulsifiers” are surface active substances which promote the suspension of one liquid in another and promote the formation of a stable mixture, or emulsion, of oil and water. Common emulsifiers are metallic soaps, certain animal and vegetable oils, and various polar compounds. Suitable emulsifiers include acacia, anionic emulsifying wax, calcium stearate, carbomers, cetostearyl alcohol, cetyl alcohol, cholesterol, diethanolamine, ethylene glycol palmitostearate, glycerin monostearate, glyceryl monooleate, hydroxypropyl cellulose, hypromellose, lanolin, hydrous, lanolin alcohols, lecithin, medium-chain triglycerides, methylcellulose, mineral oil and lanolin alcohols, monobasic sodium phosphate, monoethanolamine, nonionic emulsifying wax, oleic acid, poloxamer, poloxamers, polyoxyethylene alkyl ethers, polyoxyethylene castor oil derivatives, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene stearates, propylene glycol alginate, selfemulsifying glyceryl monostearate, sodium citrate dehydrate, sodium lauryl sulfate, sorbitan esters, stearic acid, sunflower oil, tragacanth, triethanolamine, xanthan gum and combinations thereof. In one embodiment, the emulsifier is glycerol stearate.

[0095] A “lotion” is a low- to medium -viscosity liquid formulation. A lotion can contain finely powdered substances that are in soluble in the dispersion medium through the use of suspending agents and dispersing agents. Alternatively, lotions can have as the dispersed phase liquid substances that are immiscible with the vehicle and are usually dispersed by means of emulsifying agents or other suitable stabilizers. In one embodiment, the lotion is in the form of an emulsion having a viscosity of between 100 and 1000 centistokes. The fluidity of lotions permits rapid and uniform application over a wide surface area. Lotions are typically intended to dry on the skin leaving a thin coat of their medicinal components on the skin's surface.

[0096] A “cream” is a viscous liquid or semi-solid emulsion of either the “oil-in-water” or “water-in-oil type”. Creams may contain emulsifying agents and / or other stabilizing agents. In one embodiment, the formulation is in the form of a cream having a viscosity of greater than 1000 centistokes, typically in the range of 20,000-50,000 centistokes. Creams are often time preferred over ointments as they are generally easier to spread and easier to remove.

[0097] An “ointment” is a semisolid preparation containing an ointment base and optionally one or more active agents. Examples of suitable ointment bases include hydrocarbon bases (e.g., petrolatum, white petrolatum, yellow ointment, and mineral oil); absorption bases (hydrophilic petrolatum, anhydrous lanolin, lanolin, and cold cream); water-removable bases (e.g., hydrophilic ointment), and water-soluble bases (e.g., polyethylene glycol ointments). Pastes typically differ from ointments in that they contain a larger percentage of solids. Pastes are typically more absorptive and less greasy that ointments prepared with the same components.

[0098] A “gel” is a semisolid system containing dispersions of small or large molecules in a liquid vehicle that is rendered semisolid by the action of a thickening agent or polymeric material dissolved or suspended in the liquid vehicle. The liquid may include a lipophilic component, an aqueous component or both. Some emulsions may be gels or otherwise include a gel component. Some gels, however, are not emulsions because they do not contain a homogenized blend of immiscible components. Suitable gelling agents include, but are not limited to, modified celluloses, such as hydroxypropyl cellulose and hydroxyethyl cellulose; Carbopol homopolymers and copolymers; and combinations thereof. Suitable solvents in the liquid vehicle include, but are not limited to, diglycol monoethyl ether; alklene glycols, such as propylene glycol; dimethyl isosorbide; alcohols, such as isopropyl alcohol and ethanol. The solvents are typically selected for their ability to dissolve the drug. Other additives, which improve the skin feel and / or emolliency of the formulation, may also be incorporated.Examples of such additives include, but are not limited, isopropyl myristate, ethyl acetate, C12-C15 alkyl benzoates, mineral oil, squalane, cyclomethicone, capric / caprylic triglycerides, and combinations thereof.

[0099] “Foams” consist of an emulsion in combination with a gaseous propellant. The gaseous propellant consists primarily of hydrofluoroalkanes (HF As). Suitable propellants include HF As such as 1,1,1,2-tetrafluoroethane (HFA 134a) and 1, 1,1, 2, 3,3,3- heptafluoropropane (HFA 227), but mixtures and admixtures of these and other HF As that are currently approved or may become approved for medical use are suitable. The propellantspreferably are not hydrocarbon propellant gases which can produce flammable or explosive vapors during spraying. Furthermore, the compositions preferably contain no volatile alcohols, which can produce flammable or explosive vapors during use.

[0100] Buffers are used to control pH of a composition. Preferably, the buffers buffer the composition from a pH of about 4 to a pH of about 7.5, more preferably from a pH of about 4 to a pH of about 7, and most preferably from a pH of about 5 to a pH of about 7. In a preferred embodiment, the buffer is based on triethanolamine, citric acid, sodium hydroxide, disodium phosphate and potassium phosphate.

[0101] Antioxidants may be present to prevent the deterioration of the preparations according to the invention. Examples of antioxidants are L-(+)-ascorbic Acid, ascorbyl palmitate and butylated hydroxytoluene.

[0102] Preservatives can be used to prevent the growth of fungi and microorganisms. Suitable antifungal and antimicrobial agents include, but are not limited to, benzoic acid, butylparaben, ethyl paraben, methyl paraben, propylparaben, sodium benzoate, sodium propionate, benzalkonium chloride, benzethonium chloride, benzyl alcohol, cetylpyridinium chloride, chlorobutanol, phenol, phenyl ethyl alcohol, potassium sorbate, caprylyl alcohol, 1,2- hexandiol, and thimerosal.

[0103] Viscosity modifiers can additionally be present, such as potassium chloride and natural gums such as xanthan gum, gum arabic, gum tragacanth, carrageenan, chitosan, guar gum, konjac gum, sclerotium gum, dextrins and starch.

[0104] Chelating agents may additionally be present, such as sodium glucuronate.

[0105] Fragrances may be added to the compositions of the invention.

[0106] Penetration enhancers are frequently used to promote transdermal delivery of drugs across the skin, in particular across the stratum corneum. The more commonly used enhancers include urea, (carbonyldiamide), imidurea, N, N-diethylformamide, N-methyl-2-pyrrolidine, 1 -dodecal -azacy cl opheptane-2-one, calcium thioglycate, 2-pyyrolidine, N,N-diethyl-m- toluamide, oleic acid and its ester derivatives, such as methyl, ethyl, propyl, isopropyl, butyl, vinyl and glycerylmonooleate, sorbitan esters, such as sorbitan monolaurate and sorbitan monooleate, other fatty acid esters such as isopropyl laurate, isopropyl myristate, isopropyl palmitate, diisopropyl adipate, propylene glycol monolaurate, propylene glycol monooleatea and non-ionic detergents such as BRIJ® 76 (stearyl poly(10 oxyethylene ether), BRU® 78(stearyl poly(20)oxyethylene ether), BRIJ® 96 (oleyl poly(10)oxy ethylene ether), and BRIJ® 721 (stearyl poly (21) oxyethylene ether) (ICI Americas Inc. Corp.).

[0107] Emulsion stabilizers, surfactants and emulsifying agents may additionally be present, such as sorbitan isostearate, hydroxyethyl acrylate / sodium acryloxydiethyl taurate copolymer and sorbitan isostearate.

[0108] Humectants are crucial in skincare by providing essential skin hydration and maintaining the skin's moisture balance. Exemplary humectant are Glycerin, Hyaluronic acid, Aloe vera, Honey, Hydrolyzed proteins, Panthenol, Allantoin, Seaweed & algae, Sodium PCA (sodium pyrrolidone carboxylic acid), Saccharide Isomerate, Sugar Alcohols (e.g. sorbitol), Hydroxy acids (e.g.. lactic acid and gluconolactone), Agave nectar, Betaine, Chitosan, Trehalose, Beta-glucan, Topical collagen, Galactoarabinan and propanediol.

[0109] Solvents used in the compositions of the present invention may include water, alcohols such as ethanol and isopropyl alcohol, alkanes such as Cl 5- 19 Alkane, silicone oils and mineral oils.

[0110] Skin conditioning agents may be added to the compositions of the present invention, for example caprylic / capric triglyceride, alpha-glucan triglycerides, palmitoyl tripeptide-5, glycerine, diglucosyl gallic acid, panthenol, pantolactone, sodium stearoyl glutamate, lactic acid, hydrolysed hyaluronic acid, sodium hyaluronate and maltodextrin.

[0111] Further natural extracts may be present in compositions of the present invention, for example Saccharomyces / Xylinum / Black Tea Ferment, Bellis Perennis (Daisy) Flower Extract, Thermus Thermophillus Ferment and Sphingomonas Ferment Extract.

[0112] After formulation, the product is filled into an appropriate dispenser and shipped to the end user. Examples of final container may include a pump bottle, squeeze bottle, jar, tube or vial.

[0113] A further object of the present invention is the cosmetic or medical use of a full-light skin repair composition comprising at least two of the following: iv. creatine; v. bifida ferment lysate; and / or vi . S echium Edul e Fruit Extractto repair the skin damage caused by solar radiation, in particular the DNA skin damage, even in the presence of a sunlight protecting composition.

[0114] A further object of the present invention is a cosmetic or medical method to repair the skin damage caused by solar radiation, in particular the DNA skin damage, even in the presence of a sunlight protecting composition, the method comprising administering to the skin in a way known to the skilled person of a full-light skin repair composition comprising at least two of the following: iv. creatine; v. bifida ferment lysate; and / or vi. Sechium Edule Fruit Extract.EXAMPLES

[0115] The invention is further illustrated by the following examples, which are not to be construed in any way as imposing limitations on the scope of this invention. Various other aspects, modifications, and equivalents thereof which, after reading the description herein, may suggest themselves to one of ordinary skill in the art without departing from the spirit of the present invention or the scope of the appended claims.Example I

[0116] Normal human keratinocytes were exposed to UVB radiation. After irradiation, cells were immediately treated with the components. DNA damage was quantified using a modified protocol of the single-cell gel electrophoresis assays (comet assay) with specific enzymes improving the sensitivity of the assay. T4 endonuclease V that recognizes cyclobutane pyrimidine dimers (CPD) and cleaves them to form detectable strand-breaks.DNA repair is expressed x-fold increase compared to non-treated cells. The results are shown in Table 1.Table I: DNA Repair of CPD induced by UVB irradiation on Normal Human Keratinocytes

[0117] The results clearly show the presence of a synergistic effect for both the combination of Creatine 0.5% + Sechium Edule Fruit Extract 0.035% and for the combination of Bifida Ferment Lysate 0.05% + Sechium Edule Fruit Extract 0.035% on DNA repair.5 Example II

[0118] Normal Human Keratinocytes were treated with the antioxidant, anti ox was then removed. UV Filters and reflector were applied on PMMA plate. Cells were placed under the PMMA plate and were then exposed to Blue Light irradiation. Immediately after the irradiation, cells were treated with the DNA repair components. Cells were then trypsinated 0 and embedded in agarose on microcope slides. DNA damage (oxidative lesions) was quantified using a modified protocol of the single-cell gel electrophoresis assays (comet assay) with specific enzyme improving the sensitivity of the assay, FPG, a formamidopyrimidine DNA glycosylase. DNA damage was expressed as the Olive Tail Moment (OTM; arbitrary units). 5

Claims

1. CLAIMSWhat is claimed is:

1. A cosmetic composition comprising;A. A sunlight protecting component comprising i. one or more UVA filter(s), one or more UVB filter(s) and / or one or more UVA / UVB filter(s); ii. one or more antioxidant(s); and iii. optionally one or more blue light and / or one or more IR reflector(s); andB. A full-light skin repair component comprising at least two of the following: iv. creatine; v. bifida ferment lysate; and / or vi. Sechium Edule Fruit Extract.

2. Cosmetic composition according to claim 1, wherein component B comprises v. and vi., v. and iv. or iv., v. and vi., in particular iv., v. and vi..

3. Cosmetic composition according to claim 1 or 2, wherein ingredient i. is one or more organic filter, one or more inorganic filter or mixtures thereof.

4. Cosmetic composition according to any of the preceding claims, wherein the UVA filter is BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE (BEMT) and one or more filter selected from the group consisting of BUTYL METHOXYDIBENZOYLMETHANE (avobenzone), DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE (DHHB) and Ecamsule.

5. Cosmetic composition according to any of the preceding claims, wherein the UVB filter is selected from the group consisting of DIETHYLHEXYL BUT AMIDO TRIAZONE (DHBT), ETHYLHEXYL TRIAZONE (ET), PHENYLBENZIMIDAZOLE SULFONIC ACID (PBSA), OCTYL SALICYLATE (OS) and Homosalate.

6. Cosmetic composition according to any of the preceding claims, wherein the UVA / UVB filter is Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (MBBT).

7. Cosmetic composition according to any of the preceding claims, wherein the inorganic filter is chosen in the group consisting of titanium dioxide, zinc oxide and combinations thereof.

8. Cosmetic composition according to claim 7, wherein the zinc and titanium filters are coated.

9. Cosmetic composition according to claim 8 wherein the filters are Zinc Oxide (and) Triethoxycaprylylsilane (INCI), Zinc Oxide (and) Triethoxycaprylylsilane (and) Ethyl Ferulate and / or Titanium dioxide (And) Aluminum hydroxide (And) Aluminum stearate (INCI).

10. Cosmetic composition according to any of the preceding claims, wherein the blue light and / or IR radiation reflector is at least one substantially color neutral transparent multilayer pigment based on platelet-shaped substrates.

11. Cosmetic composition according to claim 10, wherein the blue light and / or IR reflector is Mica (CI 77019) (and) Titanium Dioxide (CI 77891).

12. Cosmetic composition according to any of the preceding claims, wherein the repair component B. repairs from radiation in the range of 280-1400 nm.

13. Cosmetic composition according to any of the preceding claims, wherein the one or more antioxidant is a full-light antioxidant and / or a blue-light antioxidant.

14. Cosmetic composition according to any of the preceding claims, wherein the one or more antioxidant is a mixture of dimethyl methoxychromanol and Buddleja Officinalis Flower Extract.

15. Cosmetic composition according to any of the preceding claims, further comprising a blue light absorber.

16. Cosmetic composition according to any of the preceding claims for use in repairing sun-induced damage to the skin.

17. Cosmetic composition for use according to claim 16, wherein sun-induced damage causes senolytic or senomorphic senescence.

18. Use of a combination comprising at least two of the following: iv. creatine; v. bifida ferment lysate; and / orvi . S echium Edul e Fruit Extract in a cosmetically or pharmaceutically acceptable medium to prevent sun-induced damage to the skin, in particular to prevent senolytic or senomorphic senescence and / or appearance of the visible signs of skin aging, in particular one or more of fine lines, wrinkles, age spots, skin dryness, thinning of the skin and loss of elasticity.

19. The use according to any of claims 17 or 18, wherein the combination is added to a sunlight protecting composition comprising one or more UVA filter(s), one or more UVB filter(s) and / or one or more UVA / UVB filter(s).

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