Malonyl-coa reductase and microorganism expressing a biosynthetic pathway for the production of 3-hydroxypropionic acid
Mutating the malonyl-CoA reductase enzyme's C- and N-terminal domains enhances its activity, resulting in significantly higher 3-HP production, overcoming the limitations of the wild-type enzyme and improving biotechnological processes.
WO2026129007A1PCT designated stage Publication Date: 2026-06-25CENT NACIONAL DE PESQUISA EM ENERGIA E MATERIAIS
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- CENT NACIONAL DE PESQUISA EM ENERGIA E MATERIAIS
- Filing Date
- 2025-12-16
- Publication Date
- 2026-06-25
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Figure BR2025050587_25062026_PF_FP_ABST
Abstract
The present invention describes enzymes having malonyl-CoA reductase activity, as well as a microorganism genetically modified to express at least one of these enzymes, thereby enabling the efficient production of 3-hydroxypropionic acid (3-HP), a molecule of great industrial significance as a platform for the production of high value-added chemical compounds. The invention falls within the field of industrial biotechnology and represents an innovation in the field of metabolic engineering.
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