Method for producing l-valine

By genetically engineering Escherichia coli, mutating the thrA gene and its upstream regulatory region, and increasing the copy number of related genes, a pathway specifically consuming pyruvate and NADH was formed, solving the problems of high production cost and insufficient anaerobic growth capacity of L-valine, and realizing efficient L-valine fermentation production.

WO2026130312A1PCT designated stage Publication Date: 2026-06-25MEIHUA BIOTECH LANGFANG CO LTD
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Patent Information

Application Number
PCT/CN2025/142665
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-12-16
Filing Date
2025-12-15
Publication Date
2026-06-25

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    Figure PCTCN2025142665-FTAPPB-I100002
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    Figure PCTCN2025142665-FTAPPB-I100003
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Abstract

Provided are a method for improving the yield of L-valine and a modified bacterium, wherein the genome of the bacterium comprises a modification for reducing the feedback inhibition of L-threonine on L-threonine synthesis, and the modified bacterium can achieve production under anaerobic and aerobic conditions. In addition, a method for increasing the yield of L-valine by means of using the modified bacterium is also provided.
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