Anti -age composition

Abstract

The subject matter of the present invention is a specific composition of active ingredients that promotes cellular longevity and counteracts the action of exposomes.

Description

[0001] "Anti -age composition"

[0002] DESCRIPTION

[0003] The term "exposomes" refers to all those agents , internal , external or environmental , to which our skin is exposed .

[0004] Their ef fect is a weaker and more defenceless skin against subsequent exposures ; furthermore , the skin is less elastic, less hydrated, and less uni form in colour and surface homogeneity .

[0005] Behind a visibly aged skin, actual speci fic damage to the structural components of the skin may be concealed .

[0006] Remedying this is not always easy, since the ef fects caused by exposomes do not always appear immediately .

[0007] An approach aimed solely at resolving the issue from an aesthetic point of view, that is , only the visual aspect , is not only not resolutive , but may also play a decisive role in worsening the skin condition .

[0008] Therefore there is the need to formulate a cosmetic product in emulsion form, which includes such an invention, and which aims to restore the natural healthy conditions of the skin, those in which the skin is able to optimally perform its functions , those in which the skin i s able to defend itsel f from exposomes and, finally, those in which it is visibly smooth, even and radiant .

[0009] Summary of the invention

[0010] The authors of the present invention have surprisingly found that a speci fic combination of active ingredients is capable of restoring the ideal physiological conditions of the skin, by promoting the correct metabolism of the cells . Obj ect of the invention

[0011] In a first obj ect , the present invention describes the cosmetic composition of the active ingredients for topical use .

[0012] In a second obj ect , the present invention describes a topical cosmetic formulation comprising the composition of the invention .

[0013] In a preferred aspect , said formulation is an emulsion .

[0014] In a third obj ect, the cosmetic use of the composition and of the formulation of the invention is described .

[0015] Detailed description of the invention

[0016] In accordance with a first obj ect of the present invention, a composition of active ingredients for topical use is described . In particular, the composition of the invention comprises :

[0017] - 6— [ [ (2S) -2- [ [ (2S) -2-acetamido-5- (diaminomethylideneamino) pentanoyl] amino] propanoyl] amino ] hexanoic acid;

[0018] - a mixture of fermented Leuconostoc kimchi! (filtrate) of radish root, Phaseolus angularis seed extract, citric acid, levulinic acid, sodium levulinate;

[0019] - acetyl tetrapeptide-22 ;

[0020] - a mixture of Helianthus annuus (sunflower) sprout extract and maltodextrins.

[0021] The 6- [ [ (2S) -2- [ [ (2S) -2-acetamido-5-

[0022] (diaminomethylideneamino) pentanoyl] amino] propanoyl] amino ] hexanoic acid is a tripeptide compound having the formula shown in Figure 1.

[0023] Such compound is also known as acetyl dipeptide-3- aminohexanoic acid (also referred to as acetyl dipeptide-3-aminohexanoate ) .

[0024] For the purposes of the present invention, the 6- [ [ (2S) -2- [ [ (2S) -2-acetamido-5- (diaminomethylideneamino) pentanoyl] amino] propanoyl] amino ] hexanoic acid is present in a concentration of about 0.1-5% (w / v) and preferably of about 0.5% (w / v) with respect to the final cosmetic formulation. In a preferred aspect of the invention, the mixture of fermented Leuconostoc kimchii (filtrate) of radish root, Phaseolus angularis seed extract, citric acid, levulinic acid, sodium levulinate is present in a concentration of about 0.1-2% (w / v) with respect to the final cosmetic formulation.

[0025] Preferably, it is present in a concentration of 1% (w / v) with respect to the final cosmetic formulation.

[0026] As regards the acetyl tetrapeptide-22 , this is represented by the (2S) —2—[ [ (2S)—2—[ [ (2S)—2—[ [ (2S)—2— acet amido- 3- ( lH-imidazol-5-yl ) propanoyl ] amino ] - 4- methylpentanoyl ] amino] -4-methylpentanoyl ] amino] -5- (diaminomethylideneamino) pentanoic acid having the structure shown in Figure 2.

[0027] For the purposes of the present invention, acetyl tetrapeptide-22 is present in a concentration of about 0.1-5% (w / v) with respect to the final cosmetic formulation .

[0028] Preferably, it is present in a concentration of 1% (w / v) with respect to the final cosmetic formulation.

[0029] For the purposes of the present invention, the mixture of Helianthus annuus (sunflower) sprout extract and maltodextrins is present in a concentration of about 0.5-2% (w / v) with respect to the final cosmetic formulation . Preferably, it is present in a concentration of 1 . 7 % (w / v) with respect to the final cosmetic formulation .

[0030] In a second obj ect , the present invention describes a topical cosmetic formulation comprising the composition of the invention .

[0031] In a preferred aspect of the invention, the topical cosmetic formulation is in the form of an emulsion .

[0032] Alternatively, it may be in the form of a cream .

[0033] In this regard, therefore , the formulation comprises , together with the above-described composition, acceptable excipients suitable for a topical cosmetic formulation .

[0034] The person skilled in the art is able to prepare such a formulation based on his technical knowledge in the field; stabilisers , emulsi fiers , antimicrobials , colorants and fragrances may therefore be included, as deemed necessary .

[0035] The topical cosmetic formulation, according to the preceding claim, comprises an oil phase representing 12-

[0036] 15% of the formulation or 15-20% of the formulation or

[0037] 30% of the formulation . In particular, said oil phase comprises apolar oils , moderately polar oils and polar oils , waxes and butters .

[0038] For the purposes of the present invention, the term "apolar oils" refers to oils selected from the group comprising : C13- 14 Alkane , C9- 12 Alkane .

[0039] Apolar oils are used to improve sensorial properties , namely to make emulsions more fluid, lighter and pleasant to the touch .

[0040] For the purposes of the present invention, the term "moderately polar oils" refers to oils selected from the group comprising : Caprylic / Capric Triglyceride , Dicaprylyl Carbonate , Coco-Caprylate / Caprate .

[0041] Moderately polar oils are used to provide fluidity and reduce the greasy feeling caused by polar oils and / or waxes and / or butters that may be present .

[0042] For the purposes of the present invention, the term "polar oils" refers to oils such as Persea Gra ti ssima Oil .

[0043] Polar oils are used to provide cosmetic preparations emollience and body, together with any waxes and / or butters present .

[0044] For the purposes of the present invention, the term "waxes" refers to consistency factors , that is , they serve to provide structure to cosmetic preparations , or to increase their viscosity and thickness .

[0045] For the purposes of the present invention, the term "waxes" refers to a consistency factor belonging to the category such as : Cetyl Alcohol , Cetearyl Alcohol , Behenyl Alcohol .

[0046] For the purposes of the present invention, the term "butters" refers to compounds rich in nutrients and saturated fatty acids , with emollient , nourishing and moisturising action .

[0047] For the purposes of the present invention, "butter" refers to a compound such as : Butyro spermum Parkii Butter .

[0048] In a third obj ect , the present invention describes the cosmetic use of the composition .

[0049] In particular, the composition and the formulation of the invention are described as they have been shown to have one or more of the following ef fects :

[0050] -visibly reducing the depth of wrinkles , contributing to the improvement of skin structure and elasticity;

[0051] -exerting an antioxidant and free radical scavenger action, limiting the oxidative damage caused by endogenous and exogenous agents ; -counteracting the ef fects of ageing, photoageing and chronoageing, protecting the skin from signs of premature skin ageing induced by environmental factors and age ;

[0052] -preserving the integrity of cellular DNA, reducing the ef fects of oxidative stress caused by exposure to UV rays , pollution and other external aggressions ;

[0053] -supporting DNA repair processes and cellular longevity;

[0054] -stimulating the production of cellular defence proteins and improving skin regeneration, compared with the beginning of the treatment .

[0055] In order for the ef fects to be visible , the formulation of the invention is applied to the skin, in an appropriate amount , every day, for a period of 4-8 weeks .

[0056] From the above description, the advantages of fered by the present invention will be immediately evident to the person skilled in the art .

[0057] In particular, the composition of the invention has surprisingly been shown to optimise cellular functions and improve skin resilience in the long term . Indeed, the formulation of the invention does not merely treat the already visible signs on the skin, but acts on the fundamental biological mechanisms that characterise ageing .

[0058] This approach of regenerating, repairing and restructuring addresses various issues , such as the accumulation of DNA damage , inflammation, heat exposure damage and, in general , stress induced by exposomes , promoting skin that not only appears younger but is also healthier and more resilient .

[0059] • to reduce exogenous and endogenous skin stress that causes ageing ( collagen breakdown and inflammation) , • antioxidant against free radicals ( responsible for skin ageing) ,

[0060] • action against exposomes and factors causing cellular thermal stress ,

[0061] The composition and the formulation of the invention implement a proactive strategy for skin wellbeing, thus acting before the damage occurs .

[0062] Furthermore , the composition of the invention is stable and allows for the addition of fragrances and the preparation of equally stable formulations .

[0063] Moreover, the composition described is not photosensitising .

Claims

CLAIMS1. A cosmetic composition of the invention comprises :6 — [ [ ( 2 S ) — 2 — [ [ ( 2S ) -2-acetamido-5- (diaminomethylideneamino) pentanoyl] amino] propanoyl] amino ] hexanoic acid; a mixture of fermented (filtrate) Leuconostoc kimchi radish root, Phaseolus angularis seed extract, citric acid, levulinic acid, sodium levulinate ; acetyl tetrapeptide-22 ; a mixture of Helianthus annuus sprout extract and maltodextrins .

2. The cosmetic composition according to claim 1, wherein6- [ [ (2S) -2- [ [ (2S) -2-acetamido-5- (diaminomethylideneamino) pentanoyl] amino] propanoyl] amino ] hexanoic acid is present in a concentration of about 0.1-5% (w / v) and is preferably present in a concentration of about 0.5% (w / v) with respect to the final cosmetic formulation.

3. The cosmetic composition according to claim 1 or 2, wherein the mixture of fermented (filtrate) Leuconostoc kimchi radish root, Phaseolus angularis seed extract, citric acid, levulinic acid, sodium levulinate is present in a concentration of about 0.1-2% (w / v) withrespect to the final cosmetic formulation and preferably in a concentration of 1 % (w / v) with respect to the final cosmetic formulation .4 . The cosmetic composition according to any one of the preceding claims , wherein acetyl tetrapeptide-22 is present in a concentration of about 0 . 1 -5% (w / v) with respect to the final cosmetic formulation and is preferably present in a concentration of 1 % (w / v) with respect to the final cosmetic formulation .5 . The cosmetic composition according to any one of the preceding claims , wherein the mixture of Helianthus annuus ( sunflower ) sprout extract and maltodextrins is present in a concentration of about 0 . 5-2 % (w / v) with respect to the final cosmetic formulation and is preferably present in a concentration of 1 . 7 % (w / v) with respect to the final cosmetic formulation .

6. A topical cosmetic formulation comprising the cosmetic composition according to any one of the preceding claims .7 . The topical cosmetic formulation according to the preceding claim, which is in the form of an emulsion or a cream .8 . The topical cosmetic formulation according to the preceding claim 6 or 7 , which comprises an oil phaserepresenting 12- 15% of the formulation or 15-20% of the formulation or 30% of the formulation .

9. Cosmetic use of the composition according to any one of the preceding claims 1 to 5 or of the formulation according to any one of the preceding claims 6 to 8 .10 . Cosmetic use according to the preceding claim, wherein said use is for one or more of the following ef fects : - visibly reducing the depth of wrinkles ; improving the skin firmness ; counteracting the ef fects of aging .