Methods and compositions for cyclic analysis
The method of sequential labeling and probe removal using unlabeled blocking oligonucleotides addresses the challenge of residual signal interference in multiplexed protein detection, enabling accurate identification of both high and low-abundance analytes in biological samples.
WO2026136566A1PCT designated stage Publication Date: 2026-06-2510X GENOMICS INC
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- 10X GENOMICS INC
- Filing Date
- 2025-12-17
- Publication Date
- 2026-06-25
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Figure US2025060154_25062026_PF_FP_ABST
Abstract
The present disclosure relates to methods for analyzing a biological sample, comprising contacting the biological sample with labeling agents for detecting a panel of analytes in the biological sample and stripping one or more reagents by washing the biological sample in a buffer between detection of any two analytes. Provided herein are unlabeled blocking oligonucleotides to improve analyte detection.
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