Edible gel composition for adsorbing alcohol, preparation method therefor and use thereof

Abstract

An edible gel composition for adsorbing alcohol, a preparation method therefor and the use thereof. Raw materials of the edible gel composition for adsorbing alcohol comprise a carboxymethyl cellulose raw material, an alginic acid raw material, and a calcium source. The mass relationship between the components in the raw materials satisfies: W1=m2 / (m1+m2)×100%, and 12％≤W1≤35％; f=m4 / m3, and 0.1≤f≤1.2; wherein m1 is the mass of the carboxymethyl cellulose raw material, m2 is the mass of the alginic acid raw material, m3 is the mass of carboxyl groups in the alginic acid raw material, and m4 is the mass of Ca2+ in the calcium source.

Description

Edible gel composition for alcohol adsorption, its preparation method and its application

[0001] Cross-reference to related applications

[0002] This application claims priority to Chinese Patent Application No. 2024119216035, filed on December 25, 2024, entitled "Edible Gel Composition for Adsorbing Alcohol, Preparation Method Thereof and Application Thereof", the entire contents of which are incorporated herein by reference. Technical Field

[0003] This disclosure relates to the field of hangover relief products, and more specifically, to an edible gel composition for adsorbing alcohol, its preparation method, and its application. Background Technology

[0004] With the increasing prevalence of alcohol use globally, approximately 3 million people lose their lives annually, placing a heavy burden on society and public health. In my country, the number of drinkers and per capita alcohol consumption are also increasing year by year due to factors such as the fast pace of modern life, high work pressure, and business entertainment. Studies show that about 90% of ingested alcohol is metabolized in the liver, and excessive drinking directly damages liver cells and causes liver enzyme leakage, leading to impaired liver function. Long-term excessive drinking can induce a series of liver diseases, such as alcoholic hepatitis, fibrosis, cirrhosis, and even hepatocellular carcinoma. These diseases have become the second leading threat to liver health after other factors. Therefore, it is necessary to take steps to sober up after drinking to reduce the damage alcohol causes to the body.

[0005] Despite the abundance of hangover remedies and liver-protecting products on the market, such as hangover medications, herbal preparations, and health supplements, aimed at addressing health problems caused by excessive drinking, these products, while having some hangover-relieving effect, only become effective after alcohol enters the bloodstream and passes through the liver. This inevitably places a metabolic burden on the liver and kidneys, causing varying degrees of damage. Therefore, preventing alcohol from entering the bloodstream is key to solving these problems.

[0006] In view of this, this disclosure is hereby made. Summary of the Invention

[0007] The purpose of this disclosure is to provide an edible gel composition for adsorbing alcohol, its preparation method, and its application. Embodiments of this disclosure provide an edible gel composition that exhibits significant alcohol adsorption properties, enabling it to rapidly adsorb alcohol in the stomach, delaying the rate and time of alcohol entering the bloodstream, reducing the metabolic burden of alcohol on the body, and further mitigating the damage caused by alcohol to the nervous system.

[0008] This disclosure is implemented as follows:

[0009] In a first aspect, this disclosure provides an edible gel composition for adsorbing alcohol, the raw materials of which include carboxymethyl cellulose, alginate, and a calcium source, and the mass relationship of each component in the raw materials satisfies:

[0010] W1 = m2 / (m1+m2)×100%, and 12%≤W1≤35%;

[0011] f = m⁴ / m³, and 0.1 ≤ f ≤ 1.2;

[0012] Where m1 is the mass of carboxymethyl cellulose raw material, m2 is the mass of alginic acid raw material, m3 is the mass of carboxyl groups in alginic acid raw material, and m4 is the mass of Ca in calcium source. 2+ The quality.

[0013] In an optional embodiment, the edible gel composition has an adsorption rate of ≥700% for 43% of baijiu (Chinese liquor).

[0014] In an optional embodiment, the carboxymethyl cellulose raw material has a viscosity ≥3000 mPa·s when the concentration in the solution is 2%.

[0015] In an optional embodiment, the carboxymethyl cellulose raw material includes carboxymethyl cellulose or its salt;

[0016] Preferably, the carboxymethyl cellulose raw material includes any one of sodium carboxymethyl cellulose, potassium carboxymethyl cellulose, and ammonium carboxymethyl cellulose.

[0017] In an optional embodiment, the alginate raw material has a viscosity ≥3000 mPa·s when the concentration in the solution is 2%;

[0018] Preferably, the alginate raw material includes alginate or its salt;

[0019] Further preferably, the salt of the alginic acid includes any one of sodium alginate, potassium alginate, and ammonium alginate.

[0020] In an optional embodiment, the calcium source is a calcium source with low solubility;

[0021] Preferably, the calcium source includes at least one of calcium carbonate, calcium chloride, calcium citrate, calcium lactate, calcium gluconate, calcium acetate, and calcium phosphate; more preferably, it is one of calcium lactate, calcium carbonate, and calcium phosphate.

[0022] Secondly, this disclosure provides a method for preparing the edible gel composition for adsorbing alcohol described in the foregoing embodiments, wherein carboxymethyl cellulose raw materials, alginate raw materials and calcium source are mixed in a certain proportion.

[0023] In an optional embodiment, the method includes: mixing carboxymethyl cellulose raw materials, alginate raw materials and water, drying the mixture at 70-150°C after uniform mixing, and then pulverizing it to obtain material A;

[0024] Next, the A material and the calcium source are mixed;

[0025] Preferably, the concentrations of the carboxymethyl cellulose raw material and the alginate raw material in the water are 4-15%.

[0026] The particle size of material A is 0.1mm to 2mm, more preferably 0.3mm to 2mm, and even more preferably 0.3mm to 1mm.

[0027] Thirdly, this disclosure provides the application of the edible gel composition for adsorbing alcohol described in the foregoing embodiments in the preparation of products that adsorb alcohol.

[0028] Preferably, the product is a hangover relief health product or hangover medicine.

[0029] This disclosure offers the following beneficial effects: The embodiments of this disclosure provide an edible gel composition that exhibits significant alcohol adsorption properties. Upon ingestion, the edible gel composition rapidly adsorbs alcohol after reaching the stomach. Simultaneously, the edible gel composition possesses sufficient strength to resist the abrasive forces generated by gastric peristalsis, prolonging the residence time of the alcohol-containing edible gel composition in the stomach. This delays the rate and time of alcohol entry into the bloodstream, reducing the metabolic burden of alcohol on the body and further mitigating the damage caused by alcohol to the nervous system. The edible gel composition of this disclosure has a simple preparation process, facilitating commercial-scale production. Detailed Implementation

[0030] To make the objectives, technical solutions, and advantages of the embodiments of this disclosure clearer, the technical solutions in the embodiments of this disclosure will be clearly and completely described below. Where specific conditions are not specified in the embodiments, conventional conditions or conditions recommended by the manufacturer shall apply. Reagents or instruments whose manufacturers are not specified are all conventional products that can be purchased commercially.

[0031] In a first aspect, this disclosure provides an edible gel composition for adsorbing alcohol, the raw materials of which include carboxymethyl cellulose, alginate, and a calcium source, and the mass relationship of each component in the raw materials satisfies:

[0032] W1 = m2 / (m1+m2)×100%, and 12%≤W1≤35%;

[0033] f = m4 / m3, and 0.1 ≤ f ≤ 1.2; where m1 is the mass of carboxymethyl cellulose raw material, m2 is the mass of alginic acid raw material, m3 is the mass of carboxyl groups in alginic acid raw material, and m4 is the mass of Ca in calcium source. 2+ The quality.

[0034] The edible gel composition exhibits significant alcohol adsorption properties. After ingestion, the composition rapidly adsorbs alcohol upon reaching the stomach. Simultaneously, the composition possesses sufficient strength to resist the abrasive forces generated by stomach peristalsis, prolonging its residence time in the stomach and thus delaying the rate and duration of alcohol entry into the bloodstream. This reduces the metabolic burden of alcohol on the body and further mitigates the damage alcohol causes to the nervous system.

[0035] Therefore, the edible gel composition provided in this disclosure can be used to prepare products that adsorb alcohol, such as, but not limited to, hangover remedies and hangover medicines. Specifically, the edible gel composition has an adsorption rate of ≥700% for 43% baijiu (Chinese liquor).

[0036] Specifically, W1 can be any value between 12% and 35%, such as 12%, 15%, 17%, 20%, 25%, 30%, and 35%.

[0037] f is any value between 0.1 and 1.2, such as 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, and 1.2.

[0038] Specifically, the carboxymethyl cellulose raw material has a viscosity ≥ 3000 mPa·s when its concentration in solution is 2%. The carboxymethyl cellulose raw material includes carboxymethyl cellulose or its salts, such as, but not limited to, any one of sodium carboxymethyl cellulose, potassium carboxymethyl cellulose, and ammonium carboxymethyl cellulose.

[0039] The alginate raw material has a viscosity ≥3000 mPa·s when its concentration in solution is 2%. The alginate raw material includes alginate or its salts; for example, the alginate salts include, but are not limited to, any one of sodium alginate, potassium alginate, and ammonium alginate.

[0040] It should be noted that the viscosity mentioned above refers to the inherent properties of the alginate or carboxymethyl cellulose raw material.

[0041] This embodiment of the invention further limits the viscosity of the alginate or carboxymethyl cellulose raw materials, thereby enabling the formed edible gel composition to have a better adsorption effect on alcohol.

[0042] The calcium source is a calcium source with low solubility; for example, the calcium source includes, but is not limited to, at least one of calcium carbonate, calcium chloride, calcium citrate, calcium lactate, calcium gluconate, calcium acetate and calcium phosphate; more preferably, it is one of calcium lactate, calcium carbonate and calcium phosphate.

[0043] Secondly, this disclosure provides a method for preparing the edible gel composition for adsorbing alcohol described in the foregoing embodiments, wherein carboxymethyl cellulose raw materials, alginate raw materials and calcium source are mixed in a certain proportion.

[0044] Specifically, carboxymethyl cellulose raw materials, alginate raw materials, and water are mixed, dried at 70-150℃ after uniform mixing, and then pulverized to obtain material A. The concentration of the carboxymethyl cellulose raw materials and the alginate raw materials in the water is 4-15%, which refers to the total mass content of the carboxymethyl cellulose raw materials and the alginate raw materials in the water. The particle size of the above-mentioned material A is 0.1mm to 2mm, more preferably 0.3mm to 2mm, and even more preferably 0.3mm to 1mm.

[0045] Alternatively, you can directly mix carboxymethyl cellulose raw materials, alginate raw materials, calcium source and water.

[0046] The features and performance of this disclosure will be further described in detail below with reference to embodiments.

[0047] Example 1

[0048] This disclosure provides a method for preparing an edible gel composition, comprising:

[0049] Mix 3.0g sodium alginate, 20g sodium carboxymethyl cellulose (W1 = 13%), and 500mL water in a dough mixer until a homogeneous suspension is formed. Transfer the suspension to a metal tray, ensuring the thickness of the suspension within the tray is less than 1cm. Then, dry the tray at 70℃ for 24 hours to obtain solid material A. Grind the solid material A in a pulverizer, pass it through 16-mesh and 150-mesh sieves, and sieve to obtain granular material A with a particle size of 0.1–1mm. Package this granular material for later use.

[0050] Calcium lactate is mixed with material A, wherein the mass of calcium lactate and the mass of sodium alginate in material A satisfy f = 0.3.

[0051] Among them, the viscosity of carboxymethyl cellulose raw material is 6000 mPa·s when the concentration of the solution is 2%.

[0052] The viscosity of the alginate raw material in solution is 4000 mPa·s when the concentration is 2%.

[0053] Example 2

[0054] This disclosure provides a method for preparing an edible gel composition, comprising:

[0055] Mix 5.0g sodium alginate, 20g sodium carboxymethyl cellulose (W1 = 20%), and 500mL water in a dough mixer to form a homogeneous suspension. Transfer the suspension to a metal tray, ensuring the suspension thickness within the tray is less than 1cm. Then, dry the tray at 70℃ for 24 hours to obtain solid material A. Grind the solid material A in a pulverizer, pass it through 10-mesh and 120-mesh sieves, and sieve to obtain granular material A with a particle size of 0.1–1.7mm. Package this granular material for later use.

[0056] Calcium citrate is mixed with material A, wherein the mass of calcium citrate and the mass of sodium alginate in material A satisfy f = 0.1.

[0057] Among them, the viscosity of carboxymethyl cellulose raw material is 4000 mPa·s when the concentration of the solution is 2%.

[0058] The viscosity of alginate raw material in solution is 5000 mPa·s when the concentration is 2%.

[0059] Example 3

[0060] This embodiment provides a method for preparing an edible gel composition. The preparation method is the same as that provided in Example 2, except that f is 0.2. Other operating conditions, raw material selection and dosage are the same as in Example 2.

[0061] Example 4

[0062] This embodiment provides a method for preparing an edible gel composition. The preparation method is the same as that provided in Example 2, except that f is 0.8, the calcium source is calcium lactate, and other operating conditions, raw material selection and dosage are the same as in Example 2.

[0063] Example 5

[0064] This disclosure provides a method for preparing an edible gel composition, comprising:

[0065] 7.5g sodium alginate, 15.0g sodium carboxymethyl cellulose (W1 = 33.3%), and 500mL of water were mixed evenly in a dough mixer to form a homogeneous suspension. The suspension was transferred to a metal tray, ensuring the thickness of the suspension within the tray was less than 1cm. The tray was then dried at 70℃ for 24 hours to obtain solid material A. Solid material A was then pulverized in a grinder and passed through 18-mesh and 50-mesh sieves to obtain granular material A with a particle size of 0.27–0.88mm. This granular material was then packaged for later use.

[0066] Calcium citrate is mixed with solid material A, wherein the mass of calcium citrate and the mass of sodium alginate in material A satisfy f = 0.1.

[0067] Among them, the viscosity of carboxymethyl cellulose raw material is 12000 mPa·s when the concentration of the solution is 2%.

[0068] The viscosity of the alginate raw material in solution is 5500 mPa·s when the concentration is 2%.

[0069] Example 6

[0070] This embodiment provides a method for preparing an edible gel composition. The preparation method is the same as that provided in Example 5, except that f is 0.2. Other operating conditions, raw material selection and dosage are the same as in Example 5.

[0071] Example 7

[0072] This disclosure provides a method for preparing an edible gel composition, comprising:

[0073] Mix 5.0g sodium alginate, 20.0g sodium carboxymethyl cellulose (W1 = 20%), 3.8g calcium carbonate, and 500mL water in a dough mixer until a homogeneous suspension is formed. Transfer the suspension to a metal tray, ensuring the thickness of the suspension within the tray is less than 1cm. Then, dry the tray at 70℃ for 24 hours to obtain material A. Grind the solid material A in a pulverizer, pass it through 18-mesh and 150-mesh sieves, and sieve to obtain granular material with a particle size of 0.1–0.88mm. Package the granules for later use.

[0074] Calcium gluconate is mixed with solid material A, wherein the mass of calcium gluconate and the mass of sodium alginate in material A satisfy f = 1.2.

[0075] Among them, the viscosity of carboxymethyl cellulose raw material is 6000 mPa·s when the concentration of the solution is 2%.

[0076] The viscosity of the alginate raw material in solution is 8000 mPa·s when the concentration is 2%.

[0077] Comparative Example 1

[0078] This comparative example provides a method for preparing an edible gel composition, which is the same as the method provided in Example 1, except that f is 1.5, and other operating conditions, raw material selection and dosage are the same as in Example 1.

[0079] Comparative Example 2

[0080] This comparative example provides a method for preparing an edible gel composition, which is the same as the method provided in Example 1, except that W1 = 66.7%, and other operating conditions, raw material selection and dosage are the same as in Example 1.

[0081] Comparative Example 3

[0082] This comparative example provides a method for preparing an edible gel composition, which is the same as the method provided in Example 1, except that W1 = 66.7% and f = 1.6. Other operating conditions, raw material selection and dosage are the same as in Example 1.

[0083] Comparative Example 4

[0084] This comparative example provides a method for preparing an edible gel composition, which is the same as the method provided in Example 1, except that only 23g of sodium alginate is used, and the ratio of sodium alginate to calcium lactate is still f = 0.3.

[0085] Comparative Example 5

[0086] This comparative example provides a commercially available jelly-type hangover remedy gel, whose main ingredients are plant premix powder (psyllium husk powder, gluten powder, konjac powder, acetylated distarch phosphate, white kidney bean extract), konjac powder, carrageenan, xanthan gum, citric acid, turmeric, pectin, starch, white kidney bean powder (Phaseolus vulgaris), chia seeds, and yeast extract (glutathione).

[0087] Experimental Example 1

[0088] The national standard in China stipulates that the maximum alcohol content of baijiu (Chinese white liquor) is 68%. Under normal circumstances, the stomach acid capacity of an adult on an empty stomach is 50-100 mL; for ease of calculation, an average of 75 mL is used. If an adult drinks a maximum of 100 mL of 68% baijiu in a single sitting, the concentration of alcohol after dilution by stomach acid is calculated to be approximately 38.9%. For the convenience of the experiment, 43% commercially available baijiu was used. According to Appendix H of GB / T 22875-2018, physiological saline was replaced with 43% baijiu. The absorption amount of baijiu in Examples 1-7 and Comparative Examples 1-6 was measured. The absorption amount X*100 yields the alcohol adsorption rate (%).

[0089] The results are shown in Table 1.

[0090] Table 1. Results of alcohol adsorption rate

[0091] As shown in Table 1, if the selection of W1 or f or raw materials as defined in the embodiments of this disclosure is changed, the adsorption efficiency of the formed edible gel composition on alcohol will be greatly reduced. This further illustrates that only the edible gel composition provided in the embodiments of this disclosure can effectively achieve efficient adsorption of alcohol, indicating that it has unexpected technical effects.

[0092] Experiment Example 2

[0093] Thirty volunteers were recruited to test the real-world effects of gel compositions prepared using different methods. Volunteers consumed 2.4g of the edible gel composition from Example 4 and the jelly-type hangover remedy gel from Comparative Example 5 immediately after drinking alcohol, according to their usual drinking habits. Compared to their previous state, volunteers evaluated the anti-alcohol effect after consuming the hydrogels and categorized it as "useless," "normal," "good," or "perfect."

[0094] The results are shown in Tables 2 and 3.

[0095] Table 2 Test results of the edible gel composition of Example 4

[0096] Table 3 shows the test results of the jelly-type hangover remedy gel in Comparative Example 5.

[0097] As can be seen from Tables 2 and 3, the edible gel composition provided in the embodiments of this disclosure can effectively improve the state after drinking alcohol.

[0098] The above description is merely a preferred embodiment of this disclosure and is not intended to limit this disclosure. Various modifications and variations can be made to this disclosure by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this disclosure should be included within the scope of protection of this disclosure. Industrial applicability

[0099] The edible gel composition disclosed herein has significant adsorption properties for alcohol, enabling it to quickly adsorb alcohol in the stomach and reduce alcohol absorption. At the same time, the edible gel composition disclosed herein has a certain strength to resist the grinding force generated by gastric peristalsis, prolonging the residence time of the alcohol-containing edible gel composition in the stomach, thereby delaying the speed and time of alcohol entering the bloodstream, reducing the metabolic burden of alcohol on the body, and further reducing the damage caused by alcohol to the nervous system.

Claims

1. A comestible gel composition for adsorbing alcohol, characterized in that, Its raw materials include carboxymethyl cellulose, alginate, and calcium, and the mass relationship of each component in the raw materials satisfies: W1=m2 / (m1+m2)×100%, and 12%≤W1≤35%; f=m4 / m3, and 0.1≤f≤1.2; Where m1 is the mass of carboxymethyl cellulose raw material, m2 is the mass of alginic acid raw material, m3 is the mass of carboxyl groups in alginic acid raw material, and m4 is the mass of Ca2+ in calcium source.

2. The edible gel composition for adsorbing alcohol according to claim 1, characterized by, The edible gel composition has an adsorption rate of ≥700% for 43% baijiu (Chinese liquor).

3. The edible gel composition for adsorbing alcohol according to claim 1, wherein The carboxymethyl cellulose raw material has a viscosity ≥ 3000 mPa·S when the concentration of the solution is 2%.

4. The edible gel composition for adsorbing alcohol according to claim 1, wherein The carboxymethyl cellulose raw materials include carboxymethyl cellulose or its salts. Preferably, the carboxymethyl cellulose raw material includes any one of sodium carboxymethyl cellulose, potassium carboxymethyl cellulose, and ammonium carboxymethyl cellulose.

5. The edible gel composition for adsorbing alcohol according to claim 1, wherein The alginate raw material has a viscosity ≥3000 mPa·s when the concentration of the solution is 2%; Preferably, the alginate raw material includes alginate or its salt; More preferably, the salt of the alginic acid includes any one of sodium alginate, potassium alginate, and ammonium alginate.

6. The edible gel composition for adsorbing alcohol according to claim 1, wherein The calcium source is a calcium source with low solubility; Preferably, the calcium source includes at least one of calcium carbonate, calcium chloride, calcium citrate, calcium lactate, calcium gluconate, calcium acetate, and calcium phosphate; more preferably, it is one of calcium lactate, calcium carbonate, and calcium phosphate.

7. A process for the preparation of the edible gel composition for adsorbing alcohol as claimed in claim 1, wherein, Carboxymethyl cellulose raw materials, alginate raw materials, and calcium source are mixed in a certain proportion.

8. The production method according to claim 7, characterized by, include: Carboxymethyl cellulose raw materials, alginate raw materials and water are mixed, dried at 70-150℃ after uniform mixing, and then pulverized to obtain material A; Next, the A material and the calcium source are mixed; Preferably, the concentrations of the carboxymethyl cellulose raw material and the alginate raw material in the water are 4-15%.

9. The preparation method according to claim 8, characterized in that, The particle size of material A is 0.1mm to 2mm, more preferably 0.3mm to 2mm, and even more preferably 0.3mm to 1mm.

10. The use of the edible gel composition for adsorbing alcohol according to claim 1 in the preparation of products that adsorb alcohol; Preferably, the product is a hangover relief health product or hangover medicine.

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