Needles and related assemblies and methods for multi‑cargo delivery

Abstract

Systems and methods are provided for multi‑cargo delivery via a single needle. The needle includes a hub and a shaft extending from the hub. The shaft defines at least a portion of a first lumen in fluid communication with a first coupler and at least a portion of a second lumen in fluid communication with a second coupler. The first lumen and the second lumen are fluidically isolated from one another. The needle also includes a bevel extending from the shaft. The bevel defines a distal most contact point of the needle. The contact point is positioned laterally between a first lumen outlet and a second lumen outlet.

Description

Attomev Docket No. 1224-OOl-OlWONEEDLES AND RELATED ASSEMBLIES AND METHODS FOR MULTI-CARGO DELIVERYCross-Reference to Related Applications

[0001] This application claims priority to U.S. Provisional Application Serial No.63 / 761,912, entitled '‘Multi-Cargo 3D Printed Delivery Needles and Methods of Making and Using the Same,” filed February 22, 2025, which is incorporated herein by reference in its entirety for all purposes.Background

[0002] The embodiments described herein relate generally to a needle configured to deliver more than one cargo.

[0003] For certain needle-based delivery operations, it may be desirable to deliver two or more substances in physical proximity to one another to achieve a synergistic effect. For example, with certain steroid treatments, a local anesthetic can be included with the steroid for delivery7to the target location. As an additional example, under certain conditions it may be desirable to introduce multiple vaccines to the same portion of a patient's body. As a further example, some patients may require both long-acting and rapid-acting doses of insulin to be administered.

[0004] Although certain operations may make the delivery of two or more substances in physical proximity7desirable, incompatibilities between the substances can preclude their mixing and delivery via a single needle. In some instances, for example, the two substances can react with each other to create an undesirable substance. In some instances, the substances may have incompatible pH levels. Additionally, in some instances, it may be desirable that the two substances be delivered at different depths. In some known systems, these incompatibilities necessitate the use of multiple needles (or injection events) or an increase in the diameter of the needle, which can, in turn, increase the discomfort of the patient.

[0005] Thus, a need exists for improved systems and methods for delivering more than one cargo via a needle.Attomev Docket No. 1224-OOl-OlWOSummary

[0006] This summary introduces certain aspects of the embodiments described herein to provide a basic understanding. This summary is not an extensive overview of the inventive subject matter, and it is not intended to identify key or critical elements or to delineate the scope of the inventive subject matter.

[0007] In some embodiments, the present disclosure is directed to a needle. The needle includes a hub that has a first coupler and a second coupler. The needle also includes a shaft that has a proximal end portion coupled to the hub. The shaft defines an axial midline of the needle. The shaft defines at least a portion of a first lumen in fluid communication with the first coupler and a second lumen in fluid communication with the second coupler. The first lumen and the second lumen are each separated from the axial midline. The needle also includes a bevel that extends from a distal end portion of the shaft. The bevel defines a distal most contact point of the needle. The contact point is positioned laterally between a first lumen outlet and a second lumen outlet. The first lumen outlet is circumferentially separated from the second lumen outlet.

[0008] In some embodiments, the present disclosure is directed to a needle. The needle includes a shaft that a first lumen and a second lumen. The first lumen and the second lumen extend longitudinally within the shaft and are separated from one another. The shaft has a maximal outer diameter in a range of 0.20 mm to 0.82 mm. The needle also includes a bevel that extends from a distal end portion of the shaft. At least one of the bevel or the shaft defines a first lumen outlet in fluid communication with the first lumen. At least one of the bevel or the shaft define a second lumen outlet in fluid communication with the second lumen. The second lumen outlet has a circumferential separation with the first lumen outlet.

[0009] In some embodiments, the present disclosure is directed to a needle. The needle includes a hub that includes a first coupler and a second coupler. The needle also includes a shaft that has a proximal end portion coupled to the hub. The shaft includes a support core that extends longitudinally within the shaft. The support core defines an axial midline of the needle and has a plurality of flow-modifying protrusions that extend radially outward. The shaft finds a mixing lumen that surrounds the support core. The mixing lumen is fluidically coupled to the first coupler and the second coupler. The needle further includes a bevel that extends from a distal end portion of the shaft. One of the shaft or the bevel define a mixing-lumen outlet.Attomev Docket No. 1224-OOl-OlWO

[0010] In some embodiments, the present disclosure is directed to a method for multi-cargo delivery via a single needle. The needle includes a hub, a shaft coupled to the hub, and a bevel that extends from the shaft. The method includes coupling a first cargo source to a first coupler of the hub. The first cargo source contains a first cargo. The method also includes coupling a second cargo source to a second coupler of the hub. The second cargo source contains a second cargo. The second cargo is different from the first cargo. Additionally, method includes moving the first cargo from the first cargo source to a first lumen defined by the shaft. The first lumen is separated from an axial midline of the needle. The method further includes moving the second cargo from the second cargo source to a second lumen defined by the shaft. The second lumen is separated from the axial midline of the needle and from the first lumen. The method also includes dispensing a portion of the first cargo via a first lumen outlet and dispensing a portion of the second cargo via a second lumen outlet. The second lumen outlet is laterally separated from the first lumen outlet by a distal most contact point of the needle defined by the bevel.

[0011] In some embodiments, the present disclosure is directed to a method for cargo deliver}' via a needle. The needle includes a hub, a shaft coupled to the hub, and a bevel extending from the shaft. The method includes coupling a first cargo source to a first coupler of the hub. The first cargo source contains a first cargo. The method also includes coupling a second cargo source to a second coupler of the hub. The second cargo source contains a second cargo. The second cargo is different from the first cargo. Additionally, method includes moving the first cargo from the first cargo source and the second cargo from the second cargo source to a mixing lumen defined by the shaft. The mixing lumen surrounds a support core that extends longitudinally within the shaft. The support core has a plurality of flow-modifying protrusions that extend radially outward to within the mixing lumen. The method further includes dispensing a combined cargo via a mixing-lumen outlet defined by one of the bevel or the shaft.Brief Description of the Drawings

[0012] FIG. 1 is a perspective view of a needle according to an embodiment.

[0013] FIG. 2 is a transparent front view of the needle of FIG. 1.

[0014] FIG. 3 is a cross-sectional view of the needle of FIG. 1 taken at xi-xi.Attomev Docket No. 1224-OOl-OlWO

[0015] FIG. 4 is an enlarged transparent front view of a portion of the needle of FIG. 1 identified by the region Z2 in FIG. 2.

[0016] FIG. 5 is an enlarged transparent side view of a portion of the needle of FIG. 1 identified by the region Z1 in FIG. 1.

[0017] FIG. 6 is an enlarged transparent front view of a portion of the needle of FIG. 1 depicting an alternative positioning of a first lumen outlet and a second lumen outlet according to an embodiment.

[0018] FIG.7 is an enlarged transparent side view of a portion of the needle of FIG. 1 depicting a alternative arrangement of a set of lumen outlets according to an embodiment.

[0019] FIG. 8 is an enlarged transparent front view of a portion of the needle of FIG. 1 depicting an alternative compound curve of the lumens according to an embodiment.

[0020] FIG. 9 is an enlarged transparent front view of a portion of the needle of FIG. 1 depicting an alternative intersection point of the lumens according to an embodiment.

[0021] FIGS. 10A and 10B are enlarged transparent front views of a portion of the needle of FIG. 1 depicting alternative lumen arrangements according to embodiments.

[0022] FIG. 11 is transparent a front view of a mixing needle according to an embodiment.

[0023] FIG. 12 is a transparent front view of the mixing needle of FIG. 11 acting an alternative cargo arrangement.

[0024] FIG. 13 is an enlarged transparent front view of a portion of the needle of FIG. 11 depicting an alternative lumen arrangement according to an embodiment.

[0025] FIG. 14 is a flow chart for a method of multi-cargo delivery via a single needle according to an embodiment.

[0026] FIG. 15 is a flow chart for a method of cargo delivery via a needle according to an embodiment.Attomev Docket No. 1224-OOl-OlWODetailed Description

[0027] Generally, the present disclosure is directed to multi-cargo and / or multi-location deliver}' via a single needle. To facilitate patient comfort, the needles described herein can have a diameter that is no larger than that of a 21 gauge needle. The needles can be used to deliver the desired cargo to a delivery site that is intradermal, intravenous, transdermal, subcutaneous, or intramuscular. As described herein, a single needle can be used to deliver at least two different cargoes. For example, a single needle can be used to deliver three cargoes or four cargoes. In some embodiments, a single needle can be used to deliver ’ at least two cargoes substantially concurrently.

[0028] The cargoes can, for example, include medicaments (e.g., a small molecule drug), vaccine, adjuvant, biologic, peptide, nucleic acid, carbohydrate-based drug, lipid-based carrier, cell therapy, other molecular cargo, or any combination thereof. The cargoes can. for example, be any combination of a medicament, vaccine, adjuvant, biologic, peptide, nucleic acid, carbohydrate-based drug, lipid-based carrier, cell therapy, or other molecular cargo. The cargoes can be complementary cargoes, where the first cargo provides an additional benefit or counteracts a negative side effect of the second cargo. Some examples of complementary cargoes include, but are not limited to, a GLP-1 receptor agonist and a drug, peptide, or biologic that combats muscle loss, support muscle repair, and / or supports fat loss. For example, a GLP-1 inhibitor may be co-delivered with a peptide such as CJC-1295, Ipamorelin, GHRP-6, or BPC-157. Other examples of complementary combinations of drugs, peptides, or biologies include two or more of GHK-Cu, KPV. TB4, BPC-157, or TB-500. An advantage of the present disclosure is the ability' to co-delivery two or more cargos in a single needle.

[0029] Certain combinations of cargoes may, however, be incompatible and must be maintained separately until at the delivery site (e.g., the target location). Some examples of incompatible cargoes include, but are not limited to, some vaccines and adjuvants. Additional examples of incompatible cargos include various combinations of midazolam, hydrocortisone, vancomycin, pantoprazole, and piperacillin. For example, midazolam and hydrocortisone, hydrocortisone and vancomycin, furosemide and midazolam, heparin and pantoprazole, meropenem and pantoprazole, or pantoprazole and piperacillin / tazobactam.

[0030] In some embodiments, the needles can be configured to deliver, via a single needle and / or a single injection event, at least two cargoes (e.g., medicaments) that are kept separateAttomev Docket No. 1224-OOl-OlWOuntil deliver^'. To maintain the separation between the cargoes, the shaft of the needle can include a separate lumen (e.g.. a channel or passage) for each cargo. Accordingly, each cargo can be delivered from its respective source (e.g., container), pass through the corresponding lumen, and exit the needle via lumen outlet all without contacting the other cargo(es). The needles can, for example, concurrently deliver at least two cargoes.

[0031] To maintain a separation between the cargoes, the lumens can, for example, extend substantially in parallel within the shaft of the needle before turning to form respective lumen outlets. Rather than extending substantially parallel within the shaft, the lumens can, in some embodiments, include compound curves. For example, the non-intersecting lumens can spiral to form a double helix within the needle.

[0032] Keeping the cargo separate until delivery' can facilitate the concurrent delivery' of the cargoes while managing potential incompatibilities therebetween. The incompatibilities can affect the safety and / or efficacy of the cargoes. Examples of incompatibility types include physical incompatibility and chemical incompatibility'. Physical incompatibilities can include those that cause visible changes like color changes, precipitation, or gas formation. Non-visible physical incompatibilities can include effects on shield life and undesirable associations (e.g., Van der Waals interactions and hydrogen bonding). Chemical incompatibilities can include those that cause changes that are not visible, such as chemical degradation, chemical reactions (e.g., acid base neutralization), loss of potency, or toxic by-products. Factors that affect compatibility' can include concentration, inactive ingredients, and whether the drug is administered as a continuous infusion or intermittently. Additionally, maintaining a separation between the cargoes can also avoid negative effects on the shelf-life stability of either individual cargo. An advantage of the present disclosure is that it could eliminate the need to study stabilities of cargo (e.g., drug) stabilities, and instead the individual drug stabilities could be leveraged. This is due to the needle designs disclosed herein where the two or more cargos are kept separated until the time of delivery.

[0033] Instead of maintaining a separation between the cargoes, some needles described herein include features that facilitate mixing of the cargoes within needle such that a combined cargo is delivered to the target location. For example, the separate lumens can be formed to have one or more points of intersection that permit the cargoes to contact one another prior to delivery. In some embodiments, the needle can include a mixing lumen that extends within the shaft. The mixing lumen can facilitate the mixing of the cargoes as they pass along theAttomev Docket No. 1224-OOl-OlWOlength of the needle such that a combined cargo is delivered via at least one mixing-lumen outlet.

[0034] The needles described herein can, for example, be configured to deliver at least one cargo to two distinct locations through at least two exit ports on the needle. The exit ports can be at different longitudinal positions along the needle (e.g.. at tip of needle, or a specified distance from the tip along the side of the needle). The exit port placement can facilitate delivery of the cargo at different depths within the injection target (e.g., skin or other tissue).

[0035] Production of the needles disclosed herein is facilitated via the use of additive manufacturing techniques. Continuous liquid interface production (CLIP) like other digital light projection (DLP) methods, projects a rapid sequence of ultraviolet patterns (UV) to photopolymerize a resin layer-by-layer. Unlike other DLP methods that require layer by layer delamination between each exposure, CLIP generates a polymer structure by resin renewal underneath the build surface through a continuous liquid interface, the dead zone, created by a polymerization inhibitor (e.g., oxygen) fed through the highly oxygen permeable window at the bottom of the resin reservoir. The combination of improved optical projection and CLIP technology has allowed printers to reach submicron lateral (XY) resolution at speeds 100 times faster than other additive manufacturing methods (e.g., 3D printing).

[0036] Although CLIP provides the ability to resolve sub-micron features in the XY plane, print-through has limited the ability of stereolithographic processes to resolve negative relative to the characteristic penetration depth. However, advancements found that if a stream of fresh polymerizable resin is continuously fed through the build platform to displace trapped resin then the designed negative spaces would be preserved and eliminate print-through. Accordingly, the needles disclosed herein can be produced through a high-resolution injection continuous liquid interface production (iCLIP) process. The iCLIP process provides a method for making polymeric structures having micro-void space and can achieve micrometer X, Y, and Z resolution using synergistic control of high-resolution optical control and fluid mechanics.

[0037] As used herein, the term “about” when used in connection with a referenced numeric indication means the referenced numeric indication plus or minus up to 10 percent of that referenced numeric indication. For example, the language “about 50” covers the range of 45 to 55. Similarly, the language “about 5” covers the range of 4.5 to 5.5.Attomev Docket No. 1224-OOl-OlWO

[0038] Further, specific words chosen to describe one or more embodiments and optional elements or features are not intended to limit the invention. For example, spatially relative terms — such as “beneath”, “below”, “lower”, “above”, “upper”, “proximal”, “distal”, and the like — may be used to describe the relationship of one element or feature to another element or feature as illustrated in the figures. These spatially relative terms are intended to encompass different positions (i.e., translational placements) and orientations (i.e., rotational placements) of a device in use or operation in addition to the position and orientation shown in the figures. For example, if a device in the figures is turned over, elements described as “below” or “beneath” other elements or features would then be “above” or “over” the other elements or features. Thus, the term “below” can encompass both positions and orientations of above and below. A device may be otherwise oriented (e.g., rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly. Likewise, descriptions of movement along (translation) and around (rotation) various axes includes various spatial device positions and orientations.

[0039] Similarly, geometric terms, such as “parallel”, “perpendicular”, “round”, or “square”, are not intended to require absolute mathematical precision, unless the context indicates otherwise. Instead, such geometric terms allow for variations due to manufacturing or equivalent functions. For example, if an element is described as “round” or “generally round,” a component that is not precisely circular (e.g., one that is slightly oblong or is a many-sided polygon) is still encompassed by this description.

[0040] In addition, the singular forms “a”, “an”, and “the” are intended to include the plural forms as well, unless the context indicates otherwise. The terms “comprises”, “includes”, “has”, and the like specify the presence of stated features, steps, operations, elements, components, etc. but do not preclude the presence or addition of one or more other features, steps, operations, elements, components, or groups.

[0041] As used herein, the words “proximal” and “distal” refer to direction closer to and away from, respectively, an operator of a device. Thus, for example, the end of the needle contacting a target location (e.g., a patient’s body) would be the distal end of the needle, while the end opposite the distal end would be the proximal end.

[0042] As used in herein, the term “medicament” includes any constituent of a therapeutic substance. A medicament can include such constituents regardless of their state of matter (e.g.,Attomev Docket No. 1224-001-01WOsolid, liquid or gas). Moreover, a medicament can include the multiple constituents that can be included in a therapeutic substance in a mixed state, in an unmixed state and / or in a partially mixed state. A medicament can include both the active constituents and inert constituents of a therapeutic substance. Accordingly, as used herein, a medicament can include non-active constituents such as, water, colorant or the like.

[0043] FIGS. 1-10B depict a multi-cargo needle 1000 and alternative features thereof. The needle 1000 is configured to facilitate substantially concurrent multi-cargo and / or multi-location delivery via a single needle. For example, following a single insertion of the needle 1000 at an injection site, a first cargo (e.g., a first medicament) and a second cargo (e.g., a second medicament) can be dispensed from the needle 1000 in response to a force (e.g., a single force) applied to both a first cargo source (not shown) and a second cargo (not shown) source without removing the needle 1000 from the injection site. The first cargo source and the second cargo source can be any suitable container or reservoir (e.g., a vial, a syringe, an ampule, a flexible bag. or the like) that is placed in fluid communication with the needle 1000. In some embodiments, the force applied to the first cargo source and the second cargo source can be a single force. Said another way, one force can cause each of the first cargo and the second cargo to be dispensed from the needle 1000. In other embodiments, the first cargo is dispensed by a first force applied to the first cargo source and the second cargo is dispensed by a second force applied to the second cargo source. In some embodiments, the first cargo can be dispensed at a first injection depth while the second cargo is being dispensed at a different injection depth from the same needle 1000.

[0044] In some embodiments, the needle 1000 includes a hub 1100. The hub 1100 includes a first coupler 1110 and a second coupler 1120. The needle 1000 also includes a shaft 1200. The shaft 1200 has a proximal end portion 1202 that is coupled to the hub 1100. More specifically , in some embodiments, the proximal end portion 1202 of the shaft 1200 is coupled to a transition portion 1130 of the hub 1100. The shaft 1200 can extend from the hub 1100 along a longitudinal axis ALO of the needle 1000 in a distal direction. However, in some embodiments, the shaft 1200 can extend from the hub 1100 at an angle relative to the longitudinal axis ALO. Similarly stated, in some embodiments the shaft 1200 can be nonparallel to the longitudinal axis ALO. The shaft 1200 can define an axial midline MLA of the needle 1000. The shaft 1200 also defines at least a portion of a first lumen 1400 and a second lumen 1450. The first lumen 1400 is in fluid communication with the first coupler 1110, and theAttomev Docket No. 1224-OOl-OlWOsecond lumen 1450 is in fluid communication with the second coupler 1120. As shown in FIG.4, the first lumen 1400 and the second lumen 1450 are each separated from the axial midline MLA. For example, the first lumen 1400 and the second lumen 1450 can be separated laterally from each other and from the axial midline MLA with the axial midline MLA being therebetw een. Said another way, a lateral axis (e.g., a first lateral axis ALAI) can intersect the axial midline MLA, the first lumen 1400 can be positioned on a first side of the lateral axis, and the second lumen 1450 can be positioned on a second side of the lateral axis as depicted in FIG. 3.

[0045] The needle 1000 further includes a bevel 1300. The bevel 1300 extends from a distal end portion 1204 of the shaft 1200. The bevel 1300 defines a distal most contact point 1302 (e.g., tip) of the needle 1000. The contact point 1302 can be positioned laterally between a first lumen outlet 1402 and a second lumen outlet 1452. The first lumen outlet 1402 can be circumferentially separated from the second lumen outlet 1452. For example, in some embodiments, the contact point 1302 can be coaxial with the axial midline MLA, the first lumen outlet 1402 can be positioned on a first side of the contact point 1302, and the second lumen outlet 1452 can be positioned on a second side of the contact point 1302 as depicted in FIG. 2. Although the first lumen outlet 1402 and the second lumen outlet 1452 are shown in FIG. 2 as being defined by the bevel 1300. in other embodiments either the first lumen outlet 1402 or the second lumen outlet 1452 (or both) can be defined along any portion of the shaft 1200.

[0046] In some embodiments, the needle 1000 (and any of the needles described herein) can be formed as a single component via additive manufacturing. Accordingly, the hub 1100, the shaft 1200. and / or the bevel 1300 can be monolithically formed from a polymerized resin. For example, the hub 1100, the shaft 1200, and the bevel 1300 can be formed in a single, continuous process via the high-resolution injection continuous liquid interface production (iCLIP) described in PCT Publication No. WO 2023 / 049267 titled “Polymeric Microstructures and Systems and Methods for Making Same,” filed September 9, 2022, and PCT Publication No. WO 2024 / 086096 titled “Polymeric Structures Having a Micro-Void Space and Systems and Methods for Making Same,” each of which are incorporated herein by reference in their entirety . The high resolution of the iCLIP process in combination of its elimination of print-through facilitate the manufacture of needles with intricate internal architectures without exceeding the dimensions of corresponding traditional needles. Accordingly, the iCLIP process facilitates the production of internal structures, such as described herein, within aAttomev Docket No. 1224-OOl-OlWOneedle size envelope that cannot be manufactured via other known needle manufacturing techniques. In particular, the outer dimensions of the shaft 1200 and the bevel 1300 fall within the size envelope of a traditionally manufactured shaft and bevel with maximal outer dimensions corresponding to a 33-21 gauge needle.

[0047] In some embodiments, the polymerized resin can be one of poly caprolactone, polyalycolic acid, polylactic acid, polylactic-co-gly colic acid, polyethylene glycol, thiol-enes, anhydrides, polyacrylic acid, poly methylmethacrylate, polyvinyl alcohol, polyvinylpyrrolidone, vinyl carbonates, vinyl esters, acrylamides, hyaluronic acid, chitosan, collagen, gelatin, carboxymethylcellulose, and blends or copolymers thereof. In certain embodiments, the needle 1000 can be formed from polyethylene glycol dimethacrylate (PEGDMA).

[0048] As depicted in FIG. 2, the hub 1100 can define a proximal portion of the first lumen 1400 and a proximal portion of the second lumen 1450. The proximal portion of the first lumen 1400 can fluidically couple the portion of the first lumen 1400 defined by the shaft 1200 and the first coupler 1110. Similarly, the proximal portion of the second lumen 1450 can fluidically couple the portion of the second lumen 1450 defined by the shaft 1200 and the second coupler 1120. The first coupler 1110 and the second coupler 1120 can be configured to receive a first cargo and a second cargo from a first cargo source and a second cargo source respectively. Said another way, the first coupler 1110 can be considered to be a first cargo-source coupler and the second coupler 1120 can be considered to be a second cargo-source coupler. The first coupler 1110 and / or the second coupler 1120 can, therefore, facilitate coupling the needle 1000 to standard medicament containers (e.g.. syringes, vials, and / or bags) directly or via intermediate components, such as tubing or other fluid-carrying lines. For example, the first coupler 1110 and / or the second coupler 1120 can facilitate coupling via Luer Lock, press fit, or another standard connection mechanism. It should be appreciated that the dimensions of the hub 1100 can be tailored to facilitate the needle 1000 being concurrently coupled to at least two cargo sources that each contain a different cargo (e.g., a different medicament or other therapeutic treatment).

[0049] In some embodiments, the shaft 1200 can have a cylindrical shape. In such embodiments, a maximal outer diameter ODs (FIG. 3) can be substantially the same along the longitudinal length of the shaft 1200. However, in some embodiments, such as depicted in FIGS. 1, 2, and 4-10, the shaft 1200 can be tapered. In such embodiments, the proximal endAttomev Docket No. 1224-OOl-OlWOportion 1202 of the shaft 1200 can, as depicted in FIG. 2, can have a first outer diameter ODsi and the distal end portion 1204 of the shaft 1200 can have a second outer diameter ODs2 that is less than the first outer diameter ODsi. The difference between the first outer diameter ODsi and the second outer diameter ODs2 can be designed to minimize patient discomfort while maintaining sufficient rigidity of the needle 1000. In some embodiments, the shaft 1200 can, as depicted in FIG. 3, have a substantially circular cross-sectional shape. The substantially circular cross-sectional shape can include polygons having at least 20 sides (e.g., an icosagon). However, in some embodiments, the shaft 1200 can have a faceted cross-sectional shape (e.g., a regular or irregular polygon having less than 20 sides) that is optimized for delivery conditions. In some embodiments, the shaft 1200 can have different cross-sectional shapes at different longitudinal positions. For example, the distal end portion total for of the shaft 1200 can have a triangular cross-sectional shape that is transitioned to a polygon having at least eight sides at the proximal end portion 1202 of the shaft 1200.

[0050] In some embodiments, the bevel 1300 (and any of the bevels disclosed herein) can have a substantially conical shape. The bevel 1300 can have a substantially circular base. The substantially circular base can include polygons having at least 16 sides (e.g., a hexadecagon). The bevel 1300 can, as depicted in FIGS. 1, 2, and 4-10, form a right cone in which the distal-most contact point 1302 is aligned with (or on) the axial midline MLA of the shaft 1200. However, in some embodiments, the bevel 1300 can form an oblique cone in which the distal-most contact point 1302 is displaced laterally from the axial midline MLA to a location that is laterally inward from the maximal outer diameter of the shaft 1200. In some embodiments, the bevel 1300 can have substantially pyramidal shape having fewer than 16 sides. The shape of the bevel 1300 can be selected based on anticipated cargo delivery conditions. For example, a more conical shape can facilitate passage of the bevel 1300 through a woven material while minimizing fiber separations, while the sharp facets of a more pyramidal shape can facilitate the piercing of more resilient materials.

[0051] In yet other embodiments, the bevel 1300 (and any of the bevels disclosed herein) need not have a conical shape (either a right cone or an oblique cone) but can have any suitable shape configured to facilitate puncturing, piercing, and / or separating tissue in an efficient manner that reduces patient discomfort. For example, in some embodiments, the bevel can be shaped as a lancet point, with a bevel angle (relative to the axial midline MLA) of between about 12 degrees (providing a long bevel) and about 45 degrees (providing a more blunt tipAttomev Docket No. 1224-OOl-OlWOwith a shorter bevel). In some embodiments, the bevel 1300 can include any number of facets, such as a three-facet bevel or a five-facet bevel.

[0052] In some embodiments, a combined length of the bevel 1300 and the shaft 1200 corresponds to a target injection site. The combined length can be the longitudinal distance between the distal -most contact point 1302 and the proximal end portion 1202 of the shaft 1200. The combined length of the bevel 1300 and the shaft 1200 can, for example the range of 1.0 mm to 38 mm (e.g., 1.0 to 6.0 mm, 1.0 to 5.0 mm, 1.0 to 4.0 mm, 1.0 to 2.0 mm, 2.0 to 4.0 mm, 2.0 to 5.0 mm, 4.0 to 5.0 mm, 10 to 38 mm, 12 to 38 mm, or 25 to 38 mm). A combined length of approximately 2 mm may, for example, be designed for transdermal delivery. In other examples, a combined length of approximately 4-6 mm may be designed for subcutaneous delivery. In other examples, a combined length of approximately 12-38 mm may be designed for intravenous delivery. In still further examples, a combined length approximately 25-38 mm may be designed for intramuscular delivery. In some embodiments, the combined needle and bevel has an aspect ratio in a range of 2.5 : 1 to 20: 1.

[0053] As depicted in FIG. 4, in some embodiments, the first lumen 1400 can include a central portion 1406. The central portion 1406 can extend within the shaft 1200. In some embodiments, the central portion 1406 can be substantially parallel to the axial midline MLA of the shaft 1200. In some embodiments, the central portion 1406 can be linear and have an axis that forms angle of intersection with the axial midline MLA. Said another way, a longitudinal midline of the first lumen 1400 can be angled inward toward the axial midline MLA in the distal direction such that the distance between the axial midline MLA and the first lumen 1400 is greater at the proximal end portion 1202 of the shaft 1200 than at the distal end portion 1204 of the shaft 1200.

[0054] As further depicted in FIG. 4, in some embodiments, the first lumen 1400 can include an exit bend 1408. The exit bend 1408 fluidically couples the central portion 1406 to the first lumen outlet 1402. The exit bend 1408 is curved laterally away from the axial midline MLA and toward an outermost surface of the shaft 1200 and / or the bevel 1300. In some embodiments, the exit bend 1408 can curve laterally away from the axial midline MLA in both a first lateral direction (e.g., a lateral direction as indicated by the first lateral axis ALAI) and a second lateral direction (e.g., a lateral direction as indicated by the second lateral axis ALA2). Accordingly, the exit bend 1408 can be a compound curve. In some embodiments, the exit bend 1408 can have a radius of curvature Rc that is in a range of 2.0 to 5.0 times aAttomev Docket No. 1224-OOl-OlWOcross-sectional diameter DLI (FIG. 3) of the first lumen 1400. The exit bend 1408 can, therefore, define a smooth transition from the central portion 1406 to the first lumen outlet 1402.

[0055] In some embodiments, the central portion 1406 of the first lumen 1400 can include a curve in a first lateral direction (e.g., a position along the first lateral axis ALAI that varies with a position along the longitudinal axis ALO). In some embodiments, the central portion can also include a curve in a second lateral direction (e.g., a position along the second lateral axis ALA2 that varies with the position along the longitudinal axis ALO). In such embodiments, the first lumen 1400 has a compound curve, such as depicted in FIG. 8. This arrangement produces a delivery needle in which the fluid path (i.e., the central portion 1406 of the first lumen 1400) through the shaft 1200 has a greater length than the combined length of the bevel 1300 and the shaft 1200. In some embodiments, a ratio of a length of the central portion of the lumen to a combined length of the bevel and the shaft is greater than 1.2, 1.4, 1.5, or 2.0. In some embodiments, a ratio of a length of the central portion of the lumen to a combined length of the bevel and the shaft is between about 1.2 and 4, 1.5 and 3, 1.8 and 2.8, and 2 and 2.5. Increasing the fluid path length (for a given needle length) can provide the desired flow characteristics for repeatable, efficacious drug delivery. For example, in some embodiments, the properties of the cargo (e.g., the viscosity), the flow rate of the cargo through the first lumen 1400, and the diameter and length of the lumen can be configured to produce a fully-developed laminar flow within the fluid path. By having the fluid path longer than the combined length of the bevel 1300 and the shaft 1200, the desired flow characteristics (e.g., a fully-developed laminar flow) can be produced in needle having an overall length (i.e., a shorter needle) that may not otherwise produce the desired flow characteristics.

[0056] As depicted in FIG. 9, in some embodiments the first lumen 1400 and / or the second lumen 1450 can be curved such that the lumens defined by the shaft 1200 intersect and are placed in fluid communication with one another. The fluid communication between the lumens can facilitate a mixing of cargoes during passage through the shaft 1200. For example, the first lumen 1400 can define an intersection portion 1440 with the second lumen 1450. The first lumen 1400 and the second lumen 1450 can each be in fluid communication with the intersection portion 1440. The mixing of the first cargo delivered by the first lumen 1400 and the second cargo delivered by the second lumen 1450, at least within the intersection portionAttorney Docket No. 1224-OOl-OlWO1440, can form a combined cargo. Each of the first lumen outlet 1402 and the second lumen outlet 1452 can be sized to deliver a combined cargo at a desired flow rate.

[0057] As further depicted in FIG. 8, in some embodiments, the shaft includes or defines a support core 1220. The support core 1220 can be a solid portion of the shaft 1200 that extends continuously along the axial midline MLA to provide structural support for the shaft 1200. In some embodiments, the support core 1220 can have a different density than a remainder of the shaft 1200. In some embodiments, the first lumen 1400 can form a spiral that extends along the shaft 1200 and surrounds the support core 1220. Similarly, the second lumen 1450 can form a spiral that extends along the shaft 1200 and surrounds the support core 1220. In some embodiments, the second spiral can be clocked 180 degrees relative to the first spiral. Accordingly, the spiral formed by the first lumen 1400 can be a first spiral and the spiral formed by the second lumen 1450 can be a second spiral such that the first lumen 1400 and the second lumen 1450 are arranged in a helical configuration extending along the longitudinal axis ALO of the needle 1000. Forming the first lumen 1400 and / or the second lumen 1450 in a spiral configuration can facilitate management of the flow rate and flow characteristics of the cargoes during a dispensing operation.

[0058] As depicted in FIGS. 2 and 4-10B, the lumen outlets (e.g., the first lumen outlet 1402 and / or the second lumen outlet 1452) of the needle 1000 can be defined by an intersection of the lumens (e.g., the first lumen 1400 and / or the second lumen 1450) and an outermost surface of the shaft 1200 and / or the bevel 1300. Defining the lumens at the intersection with the outer surface of the shaft 1200 can orient the lumen outlets substantially orthogonally to a direction of insertion. This orientation can mitigate / eliminate the potential for clogging of the lumen during needle insertion.

[0059] The longitudinal positioning of the lumen outlets along the shaft 1200 can be selected based on a desired cargo delivery location (e.g.. a desired effective injection depth). The desired cargo delivery location can be proximal to a maximal insertion depth of the needle 1000 (e.g., a maximal distal position of the contact point 1302). For example, as depicted in FIGS. 4-6, a centroid CLI of the first lumen outlet 1402 can be positioned at a first longitudinal position LPi. Similarly, a centroid CL2 of the second lumen outlet 1452 can be positioned at a second longitudinal position LP2. As depicted in FIG. 4, the first longitudinal position LPi can be the same as the second longitudinal position LP2 such that the first cargo and the second cargo are dispensed at the same injection depth. Said another way, the longitudinal separationAttomev Docket No. 1224-OOl-OlWOSLPI between the first longitudinal position LPi and the contact point 1302 can be the same as the longitudinal separation SLP2 between the second longitudinal position LP2 and the contact point 1302. Alternatively, as depicted in FIG. 6, the first longitudinal position LPi can be proximal to the second longitudinal position LP2. Said another way, as an alternative to being longitudinally collocated, the longitudinal separation SLPI between the first longitudinal position LPi and the contact point 1302 can be greater than the longitudinal separation SLP2 between the second longitudinal position LP2 and the contact point 1302. Said yet another way, in some embodiments, the distal end portion 1204 of the shaft 1200 includes aheel 1210. The heel 1210 defines a transition between the shaft 1200 and the bevel 1300. The first longitudinal position LPi can be proximal to the heel, while the second longitudinal position LP2 is distal to the heel. In such an arrangement, the first lumen outlet 1402 can be defined by the shaft 1200, while the second lumen outlet 1452 can be defined by the bevel 1300 with the heel 1210 being positioned longitudinally therebetween. By positioning the lumen outlets at different longitudinal positions, the second cargo can be dispensed at a more distal injection depth than the injection depth of the first cargo. The injection depth of each cargo can, therefore, be tailored to a desired therapeutic effect.

[0060] As depicted in FIG. 5, each intersection of a lumen and the outermost surface of the shaft 1200 and / or the bevel 1300 defines a perimeter PLO of the resultant lumen outlet (e.g., the first lumen outlet 1402 and / or the second lumen outlet 1452) and, therefore, an outlet area OAL. The outlet area OAL of each lumen outlet can be sized to deliver the corresponding cargo with a design viscosity at a desired delivery rate. For example, the first lumen outlet 1402 can be defined by a first perimeter and the second lumen outlet 1452 can be defined by a second perimeter. To achieve the desired flow rate of the respective cargoes, the first perimeter can be greater than the second perimeter. Alternatively, the first and second perimeters, and corresponding outlet areas, can have the same magnitude.

[0061] As depicted in FIG. 7, in some embodiments, the first lumen outlet 1402 can be one outlet of the set of lumen outlets 1404 that are each in fluid communication with the first lumen 1400. Each lumen outlet of the set of lumen outlets 1404 can be positioned at a different longitudinal location. Additionally, each lumen outlet can have an outlet area that has a magnitude configured to establish a desired flow rate of the cargo at the specified longitudinal position. As depicted in FIG. 7, the outlet area of the lumens can vary based on the longitudinal position. For example, the distal-most lumen has a greater area than the proximal-most lumenAttomev Docket No. 1224-OOl-OlWOsuch that the delivery' pressure / volume of the cargo is managed at each location. The set of lumen outlets 1404 facilitates the delivery of the cargo concurrently at different injection depths. The set of lumen outlets 1404 can, therefore, disperse the volume being delivered over a greater thickness of the injection site material. In addition to dispersing volume, the set of lumens can facilitate the management / tailoring of a pressure front stemming from the flow of the cargo as it is delivered. Additionally, the inclusion of multiple lumens provides a backup-lumen outlet in the event of the clogging of any of the lumen outlets, such as during the injection process.

[0062] In addition to the shaping of the lumens and the placement, sizing, and quantity of the lumen outlets, in some embodiments, the shaft 1200 can include at least one flow-modifying protrusion 1230 positioned to affect the flow of the cargo through the corresponding lumen. For example, as depicted in FIG. 5, the flow-modifying protrusion(s) 1230 can partially occlude or otherwise restrict a portion of the first lumen 1400. The flow-modifying protrusion(s) 1230 can be any of a turbulator, constriction, twisted tape, wire matrix, vane, flow conditioner, baffle or other suitable structure configured to modify’ the flow of the cargo through the lumen. The flow-modify ing protrusion(s) 1230 can, for example, be positioned to impart turbulence into the flow to maintain the cargo in a mixed state and mitigate / eliminate the separation of constituent components. Although FIG. 5 shows the flowmodifying protrusions 1230 being within a lumen that is substantially linear, in other embodiments, a needle can include lumen having a first (linear) portion that includes flowmodifying protrusions to promote mixing and a second (spiraled lumen) that increase the flow7path length to produce a fully-developed exit flow.

[0063] In some embodiments, the shaft 1200 can have a maximal / av erage outer diameter ODs (FIG. 3) in a range of 0.10 mm to 1.0 mm (e.g., 0.10 to 0.82 mm, 0.10 to 0.80 mm, 0.15 to 0.80 mm, 0.20 to 0.82 mm, 0.20 to 0.80 mm, 0.25 to 0.75 mm, 0.30 to 0.70 mm, 0.35 to 0.65 mm, 0.40 to 0.60 mm. 0.45 to 0.55 mm, 0.50 to 0.55 mm, 0.20 to 0.60 mm, 0.20 to 0.65 mm, 0.20 to 0.7 mm, 0.20 to 0.75 mm, 0.70 to 1.0 mm, or 0.85 to 1.0 mm). In some embodiments, therefore, the maximal / average outer diameter ODs of the shaft 1200 can correspond to a 33 - 21 gauge, traditionally manufactured, single-lumen needle.

[0064] In some embodiments, at least the first lumen 1400 has a maximal cross-sectional diameter DLI in a range of 0.05 mm to 0.80mm (e.g., 0.05 to 0.41 mm, 0.05 to 0.40 mm, 0.05 to 0.35 mm, 0.05 to 0.30 mm, 0.10 to 0.40 mm, 0.10 to 0.35 mm, 0.10 to 0.30 mm, 0.10 to 0.20Attomev Docket No. 1224-OOl-OlWOmm, 0.40 to 0.80 mm, 0.50 to 0.80 mm, 0.55 to 0.80 mm). In some embodiments, each of the first lumen 1400 and the second lumen 1450 have a maximal cross-sectional diameter in a range of 0.05 mm to 0.80mm (e.g., 0.05 to 0.41 mm, 0.05 to 0.40 mm, 0.05 to 0.35 mm, 0.05 to 0.30 mm, 0.10 to 0.40 mm, 0.10 to 0.35 mm, 0.10 to 0.30 mm, 0.10 to 0.20 mm, 0.40 to 0.80 mm, 0.50 to 0.80 mm, 0.55 to 0.80 mm). The maximal cross-sectional diameter of the first lumen 1400 and / or the second lumen 1450 can, for example, be in a range of 10 to 100 times an average target particle size of the cargo to be delivered therethrough.

[0065] In some embodiments, the first lumen 1400 can have a first cross-sectional area L1A that is in a range of 5% to 25% (e.g. 5% to 20%, 10% to 20%, 10% to 25%, 15% to 25% or 15% to 20%) of a cross-sectional area SA of the shaft 1200 at a given longitudinal position of the shaft 1200. The cross-sectional area SA of the shaft 1200 is defined by the outer dimensions of the shaft 1200 at the given longitudinal position without distractions. Said another way, the cross-sectional area SA of the shaft 1200 corresponds to that of a solid shaft having the same external dimensions. Like the first lumen 1400, the second lumen 1450 can have a second cross-sectional area L2A that is in a range of 5% to 25% (e.g. 5% to 20%, 10% to 20%, 10% to 25%, 15% to 25% or 15% to 20%) of the cross-sectional area SA of the shaft 1200 at the given longitudinal position. In some embodiments, a combination of the first cross-sectional area LIA and the second cross-sectional area L2A can be no greater than 75% (e.g., no greater than 60% or no greater than 50%) of the total cross-sectional area SA of the shaft 1200. In some embodiments, the first cross-sectional area LIA and the second cross-sectional area L2A can have the same magnitude. Alternatively, the first cross-sectional area LIA can be different than the second cross-sectional area L2A to achieve the desired flow characteristics of the cargoes to be delivered through the respective lumens.

[0066] In addition to the first lumen 1400 and the second lumen 1450, the shaft 1200 of the needle 1000 can also define a third lumen 1460 as depicted in FIG. 10A. The third lumen 1460 can include any feature described herein with reference to the first lumen 1400 and / or depicted in FIGS. 1-9. In some embodiments, one of the first lumen 1400, the second lumen 1450, or the third lumen 1460 can have the cross-sectional diameter that is greater than that of the remaining lumens.

[0067] In addition to the first lumen 1400 and the second lumen 1450, the shaft 1200 of the needle 1000 can also define a third lumen 1460 and a fourth lumen 1470 as depicted in FIG. 10B. The third lumen 1460 and / or the fourth lumen 1470 can include any featureAttomev Docket No. 1224-OOl-OlWOdescribed herein with reference to the first lumen 1400 and / or depicted in FIGS. 1-9. In some embodiments, one of the first lumen 1400. the second lumen 1450, the third lumen 1460 or the fourth lumen 1470 can have the cross-sectional diameter that is greater than that of the remaining lumens. In yet other embodiments, any of the needles described herein can define any suitable number of lumens.

[0068] FIGS. 11 and 13 depict a multi-cargo needle 2000 and alternative features thereof. The needle 2000 is configured to facilitate the mixing of two separate cargoes therein to form a combined cargo that is dispensed from the needle 2000. The needle 2000 can also be configured to facilitate multi-location delivery via a single needle. For example, following a single insertion of the needle 2000 at an injection site, a first cargo (e.g., a first medicament) and a second cargo (e.g., a second medicament) can be dispensed from the needle 1000 in response to a force (e.g., a single force) applied to both a first cargo source (not shown) and a second cargo (not shown) source without removing the needle 2000 from the injection site. The first cargo source and the second cargo source can be any suitable container or reservoir (e.g., a vial, a syringe, an ampule, a flexible bag, or the like) that is placed in fluid communication with the needle 2000. In some embodiments, the force applied to the first cargo source and the second cargo source can be a single force. Said another way, one force can cause each of the first cargo and the second cargo to be dispensed from the needle 2000. In other embodiments, the first cargo is dispensed by a first force applied to the first cargo source and the second cargo is dispensed by a second force applied to the second cargo source.

[0069] In some embodiments, a first portion of the combined cargo can be dispensed at a first injection depth while the second portion of the combined cargo is being dispensed at a different injection depth from the same needle 2000. The needle 2000 can include any of the features, functions, elements, alternatives, and / or arrangements described herein with reference to the needle 1000 and / or depicted in FIGS. 1-10B. For example, the needle 2000, and the components thereof, can conform to the maximal external dimension limits described above with reference to the needle 1000 and special depicted in FIGS. 1-10B.

[0070] In some embodiments, the needle 2000 includes ahub 2100. The hub 2100 includes a first coupler 2110 and a second coupler 2120. The needle 2000 also includes a shaft 2200. The shaft 2200 has a proximal end portion 2202 that is coupled to the hub 2100. More specifically, in embodiments, the proximal end portion 2202 of the shaft 2200 is coupled to a transition portion 2130 of the hub 2100. The shaft 2200 can extend from the hub 2100 alongAttomev Docket No. 1224-OOl-OlWOa longitudinal axis ALO of the needle 2000 in a distal direction. However, in some embodiments, the shaft 2200 can extend from the hub 2100 at an angle relative to the longitudinal axis ALO. The shaft 2200 can include a support core 2220. The support core 2220 can extend longitudinally within the shaft 2200. The support core 2220 or the shaft 2200 can define an axial midline MLA of the needle 2000. The support core 2220 has a set of flow-modifying protrusions 2230 that extend radially outward. The shaft 2200 also defines a mixing lumen 2490. The mixing lumen 2490 surrounds the support core 2220. Accordingly, the flow-modifying protrusions 2230 extend radially outward from the support core 2220 into the mixing lumen 2490. The mixing lumen 2490 is fluidically coupled to the first coupler 2110 and the second coupler 2120. The needle 2000 further includes a bevel 2300. The bevel 2300 extends from a distal end portion 2204 of the shaft 2200. The bevel 2300 defines a distal most contact point 2302 (e.g., tip) of the needle 2000. The bevel 2300 or the shaft 2200 defines a mixing-lumen outlet 2492 met is fluidically coupled to the mixing lumen 2490.

[0071] In some embodiments, the mixing lumen 2490 can include a first inlet 2494. The first inlet 2494 can be fluidically coupled to the first coupler 2110. The mixing lumen 2490 can also include a second inlet 2496. The second inlet 2496 can be fluidically coupled to the second coupler 2120. The first inlet 2494 can be sized to deliver a first liquid cargo to the mixing lumen 2490. Similarly, the second inlet 2496 can be sized to deliver a second liquid cargo to the mixing lumen 2490. The support core 2220 is configured to produce a turbulent flow that mixes the first and second liquid cargoes as the first and second liquid cargoes are moved in a distal direction. The mixing of the first and second liquid cargoes forms a combined cargo. The mixing-lumen outlet 2492 is sized to deliver the combined cargo at a desired flow rate. For example, the mixing-lumen outlet 2492 can be sized to deliver the combined cargo at the desired flow rate for the design viscosity of the combined cargo.

[0072] As shown in FIG. 11, in some embodiments, the mixing lumen 2490 is spiral shape within the shaft 2200. In this manner, the fluid path length within the mixing lumen 2490 can be greater than the length of the shaft 2200 and / or the combined length of the shaft 2200 and the bevel 2300. In this manner, the fluid path length within the mixing lumen can be sufficient to produce the desired level of mixing within a needle shaft having an overall length that is tailored for the desired injection location, such as described herein with reference to the combined length of the bevel 1300 and the shaft 1200.Attomev Docket No. 1224-OOl-OlWO

[0073] In some embodiments, the formation of the combined cargo can include the mixing of a liquid cargo with a dry cargo. To that end, as depicted in FIG. 12. the second coupler 2120 can be positioned in series downstream of the first coupler and upstream of the first inlet 2494 to the mixing lumen 2490. In such an alternative arrangement, the first coupler 2110 can be configured to receive a liquid cargo, while the second coupler 2120 is configured to receive (or contain) a dry’ cargo. Being thus arranged, the liquid cargo can be passed through the dry cargo and the two cargoes are agitated by the support core 2220 and / or any flow modifying protrusion and mixed as they are moved in the distal direction within the mixing lumen 2490 to be delivered through the mixing-lumen outlet 2492.

[0074] As described herein with reference to the first lumen 1400, the mixing lumen 2490 can include an exit bend 2498. The exit bend 2498 fluidically couples the central portion 2497 to the mixing-lumen outlet 2492. The exit bend 2498 is curved laterally away from the axial midline MLA and toward an outermost surface of the shaft 2200 and / or the bevel 2300. In some embodiments, the exit bend 2498 can curve laterally away from the axial midline MLA in both a first lateral direction (e.g., a lateral direction as indicated by the first lateral axis ALAI (FIG. 1)) and a second lateral direction (e.g., a lateral direction as indicated by the second lateral axis ALA2 (FIG. 2)). Accordingly, the exit bend 2498 can be a compound curve. The exit bend 2498 can define a smooth transition from the central portion 2497 to the mixing-lumen outlet 2492.

[0075] As further described herein with reference to the first lumen 1400, the central portion 2497 can include a curve in a first lateral direction (e.g., a position along the first lateral axis ALAI that varies with a position along the longitudinal axis ALO). In some embodiments, the central portion can also include a curve in a second lateral direction (e.g., a position along the second lateral axis ALA2 that varies with the position along the longitudinal axis ALO). In such embodiments, the mixing lumen 2490 has a compound curve. This arrangement produces a delivery needle in which the fluid path (i.e., the central portion 2497 of the mixing lumen 2490) through the shaft 2200 has a greater length than the combined length of the bevel 2300 and the shaft 2200. In some embodiments, a ratio of a length of the central portion of the lumen to a combined length of the bevel and the shaft is greater than 1.2, 1.4, 1.5, or 2.0. In some embodiments, a ratio of a length of the central portion of the lumen to a combined length of the bevel and the shaft is between about 1.2 and 4, 1.5 and 3, 1.8 and 2.8, and 2 and 2.5. Increasing the fluid path length (for a given needle length) can provide the desired flowAttomev Docket No. 1224-OOl-OlWOcharacteristics for repeatable, efficacious drug delivery. For example, in some embodiments, the properties of the cargo (e.g.. the viscosity), the flow rate of the cargo through the mixing lumen 2490, and the diameter and length of the lumen can be configured to produce a fully-developed laminar flow within the fluid path. By having the fluid path longer than the combined length of the bevel 2300 and the shaft 2200, the desired flow characteristics (e.g., a fully-developed laminar flow) can be produced in needle having an overall length (i.e.. a shorter needle) that may not otherwise produce the desired flow characteristics.

[0076] In some embodiments, the shaft 2200 and / or the bevel 2300 can define a set of mixing-lumen outlets that are each fluidically coupled to the mixing lumen 2490. Each mixing-lumen outlet can include any of the sizing, longitudinal position, relative positioning, and other features as described herein with reference to the first lumen outlet 1402, the second lumen outlet 1452, and / or the set of lumen outlets 1404. The set of mixing-lumen outlets can facilitate delivering the combined cargo concurrently to different affective injection depths. Additionally, the set of mixing-lumen outlets can facilitate dispersal of the volume being delivered or greater thickness of the injection site material, facilitate management / tailoring of a pressure front stemming from the flow of the combined cargo as it is delivered, and / or provide a backup-lumen outlet in the event of the clogging of any of the lumen outlets.

[0077] In some embodiments, the shaft 2200 can have a maximal / average outer diameter in a range of 0.10 mm to 1.0 mm (e.g., 0.10 to 0.82 mm, 0.10 to 0.80 mm, 0.15 to 0.80 mm, 0.20 to 0.82 mm, 0.20 to 0.80 mm, 0.25 to 0.75 mm, 0.30 to 0.70 mm, 0.35 to 0.65 mm, 0.40 to 0.60 mm, 0.45 to 0.55 mm, 0.50 to 0.55 mm, 0.20 to 0.60 mm, 0.20 to 0.65 mm, 0.20 to 0.7 mm, 0.20 to 0.75 mm. 0.70 to 1.0 mm, or 0.85 to 1.0 mm). In some embodiments, therefore, the maximal / average outer diameter of the shaft 2200 can correspond to a 33 - 21 gauge, traditionally manufactured, single-lumen needle.

[0078] In some embodiments, a combined length of the bevel 2300 and the shaft 2200 corresponds to a target injection site. The combined length can be the longitudinal distance between the distal-most contact point 2302 and the proximal end portion 2202 of the shaft 2200. The combined length of the bevel 2300 and the shaft 2200 can, for example the range of 1.0 mm to 38 mm (e.g.. 1.0 to 6.0mm, 1.0 to 5.0 mm, 1.0 to 4.0 mm, 1.0 to 2.0 mm, 2.0 to 4.0 mm, 2.0 to 5.0 mm, 4.0 to 5.0 mm, 10 to 38 mm, 12 to 38 mm, or 25 to 38 mm). A combined length of approximately 2 mm may, for example, be designed for transdermal deliver}'. In other examples, a combined length of approximately 4-5 mm may be designed forAttomev Docket No. 1224-OOl-OlWOsubcutaneous delivery. In other examples, a combined length of approximately 12-38 mm may be designed for intravenous delivery. In still further examples, a combined length approximately 25-38 mm may be designed for intramuscular delivery. In some embodiments, the combined needle and bevel has an aspect ratio in a range of 2.5:1 to 20:1.

[0079] In some embodiments, the needle 2000 can be formed as a single component via additive manufacturing. Accordingly, the hub 2100, the shaft 2200, and / or the bevel 2300 can be monolithically formed from a polymerized resin. For example, the hub 2100, the shaft 2200, and the bevel 2300 can be formed in a single, continuous process via the high-resolution injection continuous liquid interface production (iCLIP) described in PCT publication WO 2023 / 049267 titled '‘Polymeric Microstructures and Systems and Methods for Making Same,” filed September 9, 2022, and PCT publication WO 2024 / 086096 titled “Polymeric Structures Having a Micro-Void Space and Systems and Methods for Making Same” each of which are incorporated herein by reference in their entirety. The high resolution of the iCLIP process in combination of its elimination of print-through facilitate the manufacture of needles with intricate internal architectures without exceeding the dimensions of corresponding traditional needles. Accordingly, the iCLIP process facilitates the production of internal structures, such as described herein, within a needle size envelope that cannot be manufactured via other known needle manufacturing techniques. In particular, the outer dimensions of the shaft 2200 and the bevel 2300 fall within the size envelope of a traditionally manufactured shaft and bevel with maximal outer dimensions corresponding to a 33-21 gauge needle.

[0080] In some embodiments, the polymerized resin can be one of poly caprolactone, polyalycolic acid, polylactic acid, polylactic-co-glycolic acid, polyethylene glycol, thiol-enes, anhydrides, polyacrylic acid, poly methylmethacrylate, polyvinyl alcohol, polyvinylpyrrolidone, vinyl carbonates, vinyl esters, acrylamides, hyaluronic acid, chitosan, collagen, gelatin, carboxymethylcellulose, and blends or copolymers thereof. In certain embodiments, the needle 2000 can be formed from polyethylene glycol dimethacrylate (PEGDMA).

[0081] In addition to the mixing lumen 2490, the shaft 2200 of the needle 2000 can also define a lumen 2400 as depicted in FIG. 13. The lumen 2400 can include any feature described herein with reference to the first lumen 1400 and / or depicted in FIGS. 1-9. In some embodiments, the mixing lumen 2490 has a cross-sectional diameter that is greater than that of the lumen 2400.Attomev Docket No. 1224-OOl-OlWO

[0082] FIG. 14 is a flow chart of a method 60 for multi-cargo delivery' via a single needle. The method 60 may. in an embodiment, be performed via the needle 1000 or the needle 2000 as described herein. However, it should be appreciated that in various embodiments, aspects of the method 60 may be accomplished via additional embodiments of the needle 1000, the needle 2000, or components thereof as described herein. Accordingly, the method 60 may be implemented via any suitable device as described herein. Thus, the method 60 is described below with reference to the needle 1000 as previous he described, but it should be understood that the method 60 can be employed using any needle described herein with reference to FIGS. 1-13.

[0083] As depicted at 61, the method 60 includes coupling a first cargo source to a first coupler of the hub. The first cargo source contains a first cargo. As depicted at 62, the method 60 includes coupling a second cargo source to a second coupler of the hub. The second cargo source contains a second cargo that is different from the first cargo. As depicted at 63, the method 60 includes moving the first cargo from the first cargo source to a first lumen defined by the shaft. The first lumen is separated from an axial midline of the needle. As depicted at 64, the method 60 includes moving the second cargo from the second cargo source to a second lumen defined by the shaft. The second lumen is separated from the axial midline of the needle and from the first lumen. As depicted at 65, the method 60 includes dispensing a portion of the first cargo via a first lumen outlet. As depicted at 66, the method 60 includes dispensing a portion of the second cargo via a second lumen outlet. The second lumen outlet is laterally separated from the first lumen outlet by a distal most contact point of the needle defined by the bevel.

[0084] FIG. 15 is a flow chart of a method 70 for cargo delivery via a needle. The method 70 may, in an embodiment, be performed via the needle 1000 or the needle 2000 as described herein. However, it should be appreciated that in various embodiments, aspects of the method 70 may be accomplished via additional embodiments of the needle 2000, the needle 1000, or components thereof as described herein. Accordingly, the method 70 may be implemented via any suitable device as described herein. Thus, the method 70 is described below with reference to the needle 2000 as previous he described, but it should be understood that the method 70 can be employed using any needle described herein with reference to FIGS. 1-13.

[0085] As depicted at 72, the method 70 includes coupling a first cargo source to a first coupler of the hub. The first cargo source contains a first cargo. As depicted at 74, the methodAttomev Docket No. 1224-OOl-OlWO70 includes coupling a second cargo source to a second coupler of the hub. The second cargo source contains a second cargo, the second cargo being different from the first cargo. As depicted at 76, the method 70 includes moving the first cargo from the first cargo source and the second cargo from the second cargo source to a mixing lumen defined by the shaft. The mixing lumen surrounds a support core and extends longitudinally within the shaft. The support core has a plurality of flow-modifying protrusions that extend radially outward to within the mixing lumen. As depicted at 78, the method 70 includes dispensing a combined cargo via a mixing-lumen outlet defined by one of the bevel or the shaft.

[0086] Although various embodiments have been described as having particular features and / or combinations of components, other embodiments are possible having a combination of any features and / or components from any of embodiments as discussed above.

[0087] In some embodiments, a cargo delivery' needle as described herein comprises a needle which is straight or angled. In some examples, the angle is determined based on the desired target region for deliver}’. In some examples, the needle is straight. In some examples, the needle straight in order to deliver the cargo intramuscularly or subcutaneously. In some examples, the needle angle is sufficient to deliver the cargo subcutaneously or intradermally. In some examples, the needle angle is approximately 45-90 degrees. In some examples, the needle angle is approximately 45-90 degrees in order to deliver the cargo subcutaneously. In some examples, the needle angle is approximately 10-15 degrees. In some examples, the needle angle is approximately 10-15 degrees in order to deliver the cargo intradermally.

[0088] While various embodiments of the invention have been described above, it should be understood that they have been presented by way of example only, and not limitation. Where methods described above indicate certain events occurring in certain order, the ordering of certain events may be modified. Additionally, certain of the events may be performed concurrently in a parallel process when possible, as well as performed sequentially’ as described above.Further Numbered Embodiments of the Disclosure

[0089] Other subject matter contemplated by the present disclosure is set out in the following numbered embodiments, which can each be combined with any other of the listed embodiments or combinations thereof:Attomev Docket No. 1224-OOl-OlWO1. A needle, comprising:a hub including a first coupler and a second coupler;a shaft having a proximal end portion coupled to the hub, the shaft defining an axial midline of the needle, the shaft defining at least a portion of a first lumen in fluid communication with the first coupler and a second lumen in fluid communication with the second coupler, the first lumen and the second lumen each being separated from the axial midline; anda bevel extending from a distal end portion of the shaft, the bevel defining a distal most contact point of the needle, the contact point being positioned laterally between a first lumen outlet and a second lumen outlet, the first lumen outlet being circumferentially separated from the second lumen outlet.2. The needle of any listed embodiment, wherein:the first lumen is fluidically isolated from the second lumen;the first lumen is configured to deliver a first cargo from a first cargo source coupled to the first coupler;the second lumen is configured to deliver a second cargo from a second cargo source coupled to the second coupler; andthe first cargo is different than the second cargo.3. The needle of any listed embodiment, wherein:the first lumen includes a central portion that extends within the shaft; and the first lumen includes an exit bend that fluidically couples the central portion to the first lumen outlet, the exit bend being curved laterally away from the axial midline.4. The needle of any listed embodiment, wherein:the exit bend has a radius of curvature that is in a range of 2.0 to 5.0 times a cross-sectional diameter of the first lumen.5. The needle of any listed embodiment, wherein:a centroid of the first lumen outlet is at a first longitudinal position;a centroid of the second lumen outlet is at a second longitudinal position; andAttomev Docket No. 1224-OOl-OlWOa longitudinal separation between the first longitudinal position and the contact point is the same as a longitudinal separation between the second longitudinal position and the contact point.6. The needle of any listed embodiment, wherein:a centroid of the first lumen outlet is at a first longitudinal position;a centroid of the second lumen outlet is at a second longitudinal position; and the first longitudinal position is proximal to the second longitudinal position.7. The needle of any listed embodiment, wherein:the distal end portion of the shaft includes a heel that defines a transition between the shaft and the bevel;the first longitudinal position is proximal to the heel; andthe second longitudinal position is distal to the heel.8. The needle of any listed embodiment, wherein:the first lumen outlet is defined by a first perimeter;the second lumen outlet is defined by a second perimeter; andthe first perimeter is greater than the second perimeter.9. The needle of any listed embodiment, wherein:an outlet area of the first lumen outlet is configured to deliver a cargo with a design viscosity' at a desired delivery rate.10. The needle of any listed embodiment, wherein:the first lumen outlet is one outlet of a plurality of lumen outlets in fluid communication with the first lumen.11. The needle of any listed embodiment, wherein:each lumen outlet of the plurality of lumen outlets has an outlet area that has a magnitude configured to establish a flow rate of a cargo therethrough; andeach lumen outlet of the plurality of lumen outlets is positioned at a different longitudinal location.Attomev Docket No. 1224-001-01WO12. The needle of any listed embodiment, wherein:the first lumen has a compound curve extending along the shaft.13. The needle of any listed embodiment, wherein:the shaft includes a support core;the first lumen forms a first spiral that extends along the shaft and surrounds the support core;the second lumen forms a second spiral that extends along the shaft and surrounds the support core; andthe second spiral is clocked 180 degrees relative to the first spiral.14. The needle of any listed embodiment, wherein:the first lumen defines an intersection portion with the second lumen; and the first lumen and the second lumen are each in fluid communication with the intersection portion; andeach of the first lumen outlet and the second lumen outlet are sized to deliver a combined cargo at a desired flow rate.15. The needle of any listed embodiment, wherein:the hub, the shaft, and the bevel are monolithically formed from a polymerized resin.16. The needle of any listed embodiment, wherein:the shaft includes at least one flow-modifying protrusion positioned to partially occlude a portion of the first lumen.17. A needle, comprising:a shaft defining a first lumen and a second lumen, the first lumen and the second lumen extending longitudinally within the shaft and being separated from one another, the shaft having a maximal outer diameter in a range of 0.20 mm to 0.82 mm; anda bevel extending from a distal end portion of the shaft, at least one of the bevel or the shaft defining a first lumen outlet in fluid communication with the first lumen, at least one of the bevel or the shaft defining a second lumen outlet in fluidAttomev Docket No. 1224-OOl-OlWOcommunication with the second lumen, the second lumen outlet having a circumferential separation with the first lumen outlet.18. The needle of any listed embodiment, wherein:each of the first lumen and the second lumen have a maximal cross-sectional diameter in a range of 0.05 mm to 0.41 mm.19. The needle of any listed embodiment, wherein:the first lumen has a first cross-sectional area that is in a range of 5 percent to 20 percent of a cross-sectional area of the shaft at a given longitudinal position along the shaft;the second lumen has a second cross-sectional area that is in a range of 5 percent to 20 percent of the cross-sectional area of the shaft at the given longitudinal position along the shaft; andthe first cross-sectional area is the same as the second cross-sectional area.20. The needle of any listed embodiment, wherein:the first lumen has a first cross-sectional area that is in a range of 5 percent to 20 percent of a cross-sectional area of the shaft at a given longitudinal position along the shaft;the second lumen has a second cross-sectional area that is in a range of 5 percent to 20 percent of the cross-sectional area of the shaft at the given longitudinal position along the shaft; andthe first cross-sectional area is different from the second cross-sectional area.21. The needle of any listed embodiment, wherein:the shaft and the bevel are monolithically formed as a single component from a polymerized resin; andthe monolithically formed single component has an aspect ratio in a range of 2.5:1 to 20:1.22. The needle of any listed embodiment, wherein:the shaft includes a support core;the support core extends longitudinally within the shaft; andAttomev Docket No. 1224-OOl-OlWOthe first lumen and the second lumen are separated from the support core.23. The needle of any listed embodiment, wherein:the maximal outer diameter is a first outer diameter of a proximal end portion of the shaft; andthe distal end portion of the shaft has a second outer diameter that is less than the first outer diameter.24. The needle of any listed embodiment, wherein:at least one of the first lumen or the second lumen has a maximal cross-sectional diameter in a range of 10 to 100 times an average target particle size of a first cargo.25. A needle, comprising:a hub including a first coupler and a second coupler;a shaft having a proximal end portion coupled to the hub, the shaft including a support core that extends longitudinally within the shaft, the support core defining an axial midline of the needle and having a plurality of flow-modifying protrusions that extend radially outward, the shaft defining a mixing lumen surrounding the support core, the mixing lumen being fluidically coupled to the first coupler and the second coupler; anda bevel extending from a distal end portion of the shaft, one of the shaft or the bevel defining a mixing-lumen outlet.26. The needle of any listed embodiment, wherein:the mixing lumen includes a first inlet fluidically coupled to the first coupler and a second inlet fluidically coupled to the second coupler;the first inlet is sized to deliver a first liquid cargo to the mixing lumen; the second inlet is sized to deliver a second liquid cargo to the mixing lumen; andthe mixing-lumen outlet is sized to deliver a combined cargo at a desired flow rate.27. The needle of any listed embodiment, wherein:Attomev Docket No. 1224-OOl-OlWOthe second coupler is positioned in series downstream of the first coupler and upstream of an inlet of the mixing lumen;the first coupler is configured to receive a liquid cargo;the second coupler is configured to receive a dry cargo; andthe mixing lumen is configured to produce a combined cargo that is delivered through the mixing-lumen outlet.28. The needle of any listed embodiment, wherein:the mixing lumen includes a central portion that extends within the shaft; the mixing lumen includes an exit bend that fluidically couples the central portion to the mixing-lumen outlet; andthe exit bend is formed to curve laterally away from the axial midline.29. The needle of any listed embodiment, wherein:the mixing lumen has a compound curve extending along the shaft.30. The needle of any listed embodiment, wherein:the shaft has a maximal outer diameter in a range of 0.20 mm to 0.82 mm; a combined length of the shaft and the bevel is in a range of 1.0 mm to 6.0 mm; andthe hub, the shaft, and the bevel are monolithically formed from a polymerized resin.31. The needle of any listed embodiment, wherein:the mixing-lumen outlet is a first mixing-lumen outlet; andone of the shaft or the bevel defines a second mixing-lumen outlet that is circumferentially separated from the first mixing-lumen outlet.32. A method for multi-cargo delivery via a single needle, the needle including a hub, a shaft coupled to the hub, and a bevel extending from the shaft, the method comprising:coupling a first cargo source to a first coupler of the hub, the first cargo source containing a first cargo;Attomev Docket No. 1224-OOl-OlWOcoupling a second cargo source to a second coupler of the hub, the second cargo source containing a second cargo, the second cargo being different from the first cargo;moving the first cargo from the first cargo source to a first lumen defined by the shaft, the first lumen being separated from an axial midline of the needle;moving the second cargo from the second cargo source to a second lumen defined by the shaft, the second lumen being separated from the axial midline of the needle and from the first lumen;dispensing a portion of the first cargo via a first lumen outlet; and dispensing a portion of the second cargo via a second lumen outlet, the second lumen outlet being laterally separated from the first lumen outlet by a distal most contact point of the needle defined by the bevel.33. The method of any listed embodiment, wherein:the portion of the first cargo and the portion of the second cargo are dispensed concurrently.34. A method for cargo delivery via a needle, the needle including a hub, a shaft coupled to the hub, and a bevel extending from the shaft, the method comprising: coupling a first cargo source to a first coupler of the hub, the first cargo source containing a first cargo;coupling a second cargo source to a second coupler of the hub, the second cargo source containing a second cargo, the second cargo being different from the first cargo;moving the first cargo from the first cargo source and the second cargo from the second cargo source to a mixing lumen defined by the shaft, the mixing lumen surrounding a support core extending longitudinally within the shaft, the support core having a plurality of flow-modifying protrusions that extend radially outward to within the mixing lumen; anddispensing a combined cargo via a mixing-lumen outlet defined by one of the bevel or the shaft.35. The method of any listed embodiment, wherein:Attomev Docket No. 1224-OOl-OlWOthe second cargo is a dry cargo positioned in series downstream of the first coupler and upstream of an inlet of the mixing lumen;the first cargo is a liquid cargo; andmoving the first cargo from the first cargo source and the second cargo from the second cargo source includes moving the liquid cargo through the dry cargo and into the mixing lumen.36. The method of any listed embodiment, wherein:the shaft has a maximal outer diameter in a range of 0.20 mm to 0.82 mm; a combined length of the shaft and the bevel is in a range of 1.0 mm to 6.0 mm; andthe hub, the shaft, and the bevel are monolithically formed from a polymerized resin.37. The method of any listed embodiment, wherein:the mixing-lumen outlet is a first mixing-lumen outlet; andone of the shaft or the bevel defines a second mixing-lumen outlet that is circumferentially separated from the first mixing-lumen outlet.

Claims

Attomev Docket No. 1224-OOl-OlWOClaimsWhat is claimed is:

1. A needle, comprising:a hub including a first coupler and a second coupler;a shaft having a proximal end portion coupled to the hub, the shaft defining an axial midline of the needle, the shaft defining at least a portion of a first lumen in fluid communication with the first coupler and a second lumen in fluid communication with the second coupler, the first lumen and the second lumen each being separated from the axial midline; anda bevel extending from a distal end portion of the shaft, the bevel defining a distal most contact point of the needle, the contact point being positioned laterally between a first lumen outlet and a second lumen outlet, the first lumen outlet being circumferentially separated from the second lumen outlet.

2. The needle of claim 1 , wherein:the first lumen is fluidically isolated from the second lumen;the first lumen is configured to deliver a first cargo from a first cargo source coupled to the first coupler;the second lumen is configured to deliver a second cargo from a second cargo source coupled to the second coupler; andthe first cargo is different than the second cargo.

3. The needle of claim 1 , wherein:the first lumen includes a central portion that extends within the shaft; and the first lumen includes an exit bend that fluidically couples the central portion to the first lumen outlet, the exit bend being curved laterally away from the axial midline.

4. The needle of claim 3, wherein:the exit bend has a radius of curvature that is in a range of 2.0 to 5.0 times a cross-sectional diameter of the first lumen.

5. The needle of claim 1, wherein:a centroid of the first lumen outlet is at a first longitudinal position;Attomev Docket No. 1224-OOl-OlWOa centroid of the second lumen outlet is at a second longitudinal position; and a longitudinal separation between the first longitudinal position and the contact point is the same as a longitudinal separation between the second longitudinal position and the contact point.

6. The needle of claim 1 , wherein:a centroid of the first lumen outlet is at a first longitudinal position;a centroid of the second lumen outlet is at a second longitudinal position; and the first longitudinal position is proximal to the second longitudinal position.

7. The needle of claim 6, wherein:the distal end portion of the shaft includes a heel that defines a transition between the shaft and the bevel;the first longitudinal position is proximal to the heel; andthe second longitudinal position is distal to the heel.

8. The needle of claim 1 , wherein:the first lumen outlet is defined by a first perimeter;the second lumen outlet is defined by a second perimeter; andthe first perimeter is greater than the second perimeter.

9. The needle of claim 1 , wherein:an outlet area of the first lumen outlet is configured to deliver a cargo with a design viscosity at a desired delivery rate.

10. The needle of claim 1, wherein:the first lumen outlet is one outlet of a plurality of lumen outlets in fluid communication with the first lumen.

11. The needle of claim 10, wherein:each lumen outlet of the plurality of lumen outlets has an outlet area that has a magnitude configured to establish a flow rate of a cargo therethrough; andeach lumen outlet of the plurality of lumen outlets is positioned at a different longitudinal location.Attomev Docket No. 1224-OOl-OlWO12. The needle of claim 1, wherein:the first lumen has a compound curve extending along the shaft.

13. The needle of claim 1, wherein:the shaft includes a support core;the first lumen forms a first spiral that extends along the shaft and surrounds the support core;the second lumen forms a second spiral that extends along the shaft and surrounds the support core; andthe second spiral is clocked 180 degrees relative to the first spiral.

14. The needle of claim 1, wherein:the first lumen defines an intersection portion with the second lumen; and the first lumen and the second lumen are each in fluid communication with the intersection portion; andeach of the first lumen outlet and the second lumen outlet are sized to deliver a combined cargo at a desired flow rate.

15. The needle of claim 1, wherein:the hub, the shaft, and the bevel are monolithically formed from a polymerized resin.

16. The needle of claim 1, wherein:the shaft includes at least one flow-modifying protrusion positioned to partially occlude a portion of the first lumen.

17. A needle, comprising:a shaft defining a first lumen and a second lumen, the first lumen and the second lumen extending longitudinally within the shaft and being separated from one another, the shaft having a maximal outer diameter in a range of 0.20 mm to 0.82 mm; anda bevel extending from a distal end portion of the shaft, at least one of the bevel or the shaft defining a first lumen outlet in fluid communication with the first lumen, at least one of the bevel or the shaft defining a second lumen outlet in fluid communication with the secondAttomev Docket No. 1224-OOl-OlWOlumen, the second lumen outlet having a circumferential separation with the first lumen outlet.

18. The needle of claim 17, wherein:each of the first lumen and the second lumen have a maximal cross-sectional diameter in a range of 0.05 mm to 0.41 mm.

19. The needle of claim 17, wherein:the first lumen has a first cross-sectional area that is in a range of 5 percent to 20 percent of a cross-sectional area of the shaft at a given longitudinal position along the shaft;the second lumen has a second cross-sectional area that is in a range of 5 percent to 20 percent of the cross-sectional area of the shaft at the given longitudinal position along the shaft; andthe first cross-sectional area is the same as the second cross-sectional area.

20. The needle of claim 17, wherein:the first lumen has a first cross-sectional area that is in a range of 5 percent to 20 percent of a cross-sectional area of the shaft at a given longitudinal position along the shaft;the second lumen has a second cross-sectional area that is in a range of 5 percent to 20 percent of the cross-sectional area of the shaft at the given longitudinal position along the shaft; andthe first cross-sectional area is different from the second cross-sectional area.

21. The needle of claim 17, wherein:the shaft and the bevel are monolithically formed as a single component from a polymerized resin; andthe monolithically formed single component has an aspect ratio in a range of 2.5:1 to 20:1.

22. The needle of claim 17, wherein:the shaft includes a support core;the support core extends longitudinally within the shaft; andthe first lumen and the second lumen are separated from the support core.Attomev Docket No. 1224-OOl-OlWO23. The needle of claim 17, wherein:the maximal outer diameter is a first outer diameter of a proximal end portion of the shaft; andthe distal end portion of the shaft has a second outer diameter that is less than the first outer diameter.

24. The needle of claim 17, wherein:at least one of the first lumen or the second lumen has a maximal cross-sectional diameter in a range of 10 to 100 times an average target particle size of a first cargo.

25. A needle, comprising:a hub including a first coupler and a second coupler;a shaft having a proximal end portion coupled to the hub, the shaft including a support core that extends longitudinally within the shaft, the support core defining an axial midline of the needle and having a plurality of flow-modifying protrusions that extend radially outward, the shaft defining a mixing lumen surrounding the support core, the mixing lumen being fluidically coupled to the first coupler and the second coupler; anda bevel extending from a distal end portion of the shaft, one of the shaft or the bevel defining a mixing-lumen outlet.

26. The needle of claim 25, wherein:the mixing lumen includes a first inlet fluidically coupled to the first coupler and a second inlet fluidically coupled to the second coupler;the first inlet is sized to deliver a first liquid cargo to the mixing lumen;the second inlet is sized to deliver a second liquid cargo to the mixing lumen; and the mixing-lumen outlet is sized to deliver a combined cargo at a desired flow rate.

27. The needle of claim 25, wherein:the second coupler is positioned in series downstream of the first coupler and upstream of an inlet of the mixing lumen;the first coupler is configured to receive a liquid cargo;the second coupler is configured to receive a dry cargo; andthe mixing lumen is configured to produce a combined cargo that is delivered through the mixing-lumen outlet.Attomev Docket No. 1224-OOl-OlWO28. The needle of claim 25, wherein:the mixing lumen includes a central portion that extends within the shaft;the mixing lumen includes an exit bend that fluidically couples the central portion to the mixing-lumen outlet; andthe exit bend is formed to curve laterally away from the axial midline.

29. The needle of claim 25, wherein:the mixing lumen has a compound curve extending along the shaft.

30. The needle of claim 25, wherein:the shaft has a maximal outer diameter in a range of 0.20 mm to 0.82 mm;a combined length of the shaft and the bevel is in a range of 1.0 mm to 6.0 mm; and the hub, the shaft, and the bevel are monolithically formed from a polymerized resin.

31. The needle of claim 25, wherein:the mixing-lumen outlet is a first mixing-lumen outlet; andone of the shaft or the bevel defines a second mixing-lumen outlet that is circumferentially separated from the first mixing-lumen outlet.

32. A method for multi-cargo delivery via a single needle, the needle including a hub, a shaft coupled to the hub, and a bevel extending from the shaft, the method comprising:coupling a first cargo source to a first coupler of the hub, the first cargo source containing a first cargo;coupling a second cargo source to a second coupler of the hub, the second cargo source containing a second cargo, the second cargo being different from the first cargo; moving the first cargo from the first cargo source to a first lumen defined by the shaft, the first lumen being separated from an axial midline of the needle;moving the second cargo from the second cargo source to a second lumen defined by the shaft, the second lumen being separated from the axial midline of the needle and from the first lumen;dispensing a portion of the first cargo via a first lumen outlet; andAttomev Docket No. 1224-OOl-OlWOdispensing a portion of the second cargo via a second lumen outlet, the second lumen outlet being laterally separated from the first lumen outlet by a distal most contact point of the needle defined by the bevel.

33. The method of claim 32, wherein:the portion of the first cargo and the portion of the second cargo are dispensed concurrently.

34. A method for cargo delivery via a needle, the needle including a hub, a shaft coupled to the hub, and a bevel extending from the shaft, the method comprising:coupling a first cargo source to a first coupler of the hub, the first cargo source containing a first cargo;coupling a second cargo source to a second coupler of the hub, the second cargo source containing a second cargo, the second cargo being different from the first cargo; moving the first cargo from the first cargo source and the second cargo from the second cargo source to a mixing lumen defined by the shaft, the mixing lumen surrounding a support core extending longitudinally within the shaft, the support core having a plurality of flow-modifying protrusions that extend radially outward to within the mixing lumen; and dispensing a combined cargo via a mixing-lumen outlet defined by one of the bevel or the shaft.

35. The method of claim 34, wherein:the second cargo is a dry cargo positioned in series downstream of the first coupler and upstream of an inlet of the mixing lumen;the first cargo is a liquid cargo; andmoving the first cargo from the first cargo source and the second cargo from the second cargo source includes moving the liquid cargo through the dry cargo and into the mixing lumen.

36. The method of claim 34, wherein:the shaft has a maximal outer diameter in a range of 0.20 mm to 0.82 mm;a combined length of the shaft and the bevel is in a range of 1.0 mm to 6.0 mm; and the hub, the shaft, and the bevel are monolithically formed from a polymerized resin.Attomev Docket No. 1224-OOl-OlWO37. The method of claim 34, wherein:the mixing-lumen outlet is a first mixing-lumen outlet; andone of the shaft or the bevel defines a second mixing-lumen outlet that is circumferentially separated from the first mixing-lumen outlet.

Images