COMPOSIÇÃO FUNGICIDA PARA CONTROLAR A INFECÇÃO POR ZYMOSEPTORIA EM PLANTAS

Description

1 / 77 Fungicidal composition to control Zymoseptoria infection in plants. SPLIT ORDER FROM BR 11 2021 021139 0 FIELD OF THE INVENTION

[0001] The present invention relates to a fungicidal composition comprising a multi-site fungicide for controlling phytopathogenic fungi in plants. The present invention also relates to the use of said composition for the control of fungal infection and to a method for the prevention and / or treatment of fungal leaf spot diseases caused by Zymoseptoria infection in plants. BACKGROUND OF THE INVENTION

[0002] Septoria tritici (taxonomic name: Zymoseptoria tritici) is a haploid ascomycete fungus, formerly called Mycosphaerella graminicola. Zymoseptoria tritici (Z. tritici) is a pathogenic fungus that causes one of the most serious wheat diseases worldwide, septoria tritici blotch (STB). STB outbreaks can reduce wheat yields by 30–40%, and Z. tritici is therefore a major threat to global food security. This pathogen is of particular concern in humid climates, such as those found in European countries, where an estimated wheat yield of up to 700 million euros is lost annually to STB (Fones and Gurr, 2015). There are no wheat varieties that are completely resistant to this pathogen, and disease control relies heavily on chemical application. However, there are limitations regarding the reduction in the use of fungicides, according to policies in Europe.Furthermore, frequent sexual recombination within the pathogen population leads to polymorphisms and the evolution of virulent strains that can overcome host resistance and tolerance to fungicides, thus becoming very... Petition 870260041192, dated 04 / 05 / 2026, page 91 / 172 2 / 77 difficult to control. Therefore, there is an urgent need to further understand Z. tritici and its interaction with its wheat host in order to provide future control strategies.

[0003] Wheat is one of the most intensively produced cereals worldwide, representing approximately 21% of dietary calories and 20% of protein intake for 4.5 billion people (Braun et al., 2010). Crop loss due to pathogens, animals, and weeds accounts for 20 to 40% of yield (Oerke, 2006). Therefore, disease control needs to play a significant role in increasing cereal production while having a minimal impact on already limited resources such as land and water.

[0004] STB is currently controlled with the use of fungicides. The fungicides commonly used to control Z. tritici are single-site fungicides such as demethylation inhibitors (DMIs), succinate dehydrogenase inhibitors (SDHIs), and multi-site fungicides including chlorothalonil (Torriani et al., 2015). However, the development of fungicide resistance remains a concern. Extensive fungicide applications increase the economic costs worldwide attributed to STB.

[0005] Captan is a non-systemic fungicide used to control diseases in many fruit, ornamental, and vegetable crops. It is used in agricultural production as well as in home gardening. Captan can be used to control plant diseases such as black rot, early and late blight, and velvety mildew, among others.

[0006] Folpete, a chloroalkylthio compound with a broad-spectrum protective fungicide (N-(trichloromethylthio)phthalimide), has been used by Petition 870260041192, dated 04 / 05 / 2026, page 92 / 172 3 / 77 last decades. Folpet is predominantly used in agricultural practice along with other industrial applications today.

[0007] Document No. US2010331181 discloses a method for protecting cereals from being infected by harmful fungi, in which the cereals, their seed or the soil are treated with an effective amount as a fungicide of a synergistically active combination comprising a) bixaphene or N-[2-(1,3-dimethylbutyl)-phenyl]-1,3-dimethyl-5-fluoro-1H-pyrazole-4-carboxamide and b) epoxiconazole or metconazole.

[0008] Document no. WO2015113838 discloses a method for controlling Septoria tritici in cereal plants, comprising treating the plants, their seed or the soil with an effective amount as a fungicide of a composition comprising (a) pyraclostrobin or picoxystrobin compound and (b) prothioconazole or propiconazole compound.

[0009] Document No. WO2017162567 refers to a method for controlling septoria leaf spot in cereal plants caused by Zymoseptoria tritici containing the V136A and / or I381V mutation and, optionally, the G143A mutation, comprising treating cereal plants, their grain or the soil with a composition comprising (a) a prothioconazole compound and (b) a difenoconazole or tebuconazole compound and (c) at least one strobilurin fungicidal compound.

[0010] Document no. WO2018069114 discloses a method for controlling SDHI fungicide-resistant Septoria tritici in cereals comprising treating plants with pidiflumetophen.

[0011] Therefore, the present invention relates to an innovative composition that effectively controls fungal leaf spot diseases caused by Zymoseptoria fungi in plants, as well as to a method for treating plants that provides excellent control over the Petition 870260041192, dated 04 / 05 / 2026, page 93 / 172 4 / 77 combats plant diseases and provides high yields, maintaining plant nutrition and quality. Objectives of the invention

[0012] The present invention, described further in this document, achieves at least one of the following objectives of the invention.

[0013] One objective of the present invention is to provide a fungicidal composition comprising a multi-site fungicide for controlling zymoseptoria infection in plants.

[0014] Another objective of the present invention is to provide a fungicidal composition comprising a multi-site fungicide for the treatment of fungal leaf spot diseases caused by the fungus Zymoseptoria in plants.

[0015] Another objective of the present invention is to provide the use of a multi-site contact fungicide to control the zymoseptoria fungus in plants.

[0016] Another objective of the present invention is to provide the use of multisite fungicides for the treatment of septoria leaf spot disease in plants.

[0017] Another objective of the present invention is to provide the use of multisite fungicides for the treatment of septoria leaf spot diseases caused by zymoseptoria fungi in plants.

[0018] Another objective of the present invention is to provide a method for preventing and / or controlling zymoseptoria infection in plants.

[0019] Another objective of the present invention is to provide a method of controlling Zymoseptoria infection in plants that increases the level of nutrients in the plants and improves plant quality. Petition 870260041192, dated 04 / 05 / 2026, page 94 / 172 5 / 77

[0020] Another objective of the present invention is to provide a method for treating septoria leaf spot disease in plants in such a way that the amounts of fungicides used in the treatment are greatly reduced.

[0021] Another objective of the present invention is to provide a method for controlling the Zymoseptoria fungus in plants wherein the fungicides used provide effective treatment of septoria leaf spot disease. SUMMARY OF THE INVENTION

[0022] In another aspect, the present invention provides a fungicidal composition for controlling zymoseptoria infection in plants.

[0023] In one aspect, the present invention provides a fungicidal composition for controlling zymoseptoria infection in a host legume plant.

[0024] In one aspect, the present invention provides a fungicidal composition comprising at least one fungicide selected from captan, folpet, captafol or combinations thereof to control zymoseptoria infection in cereal plants.

[0025] In one aspect, the present invention provides a fungicidal composition comprising captan for controlling zymoseptoria infection in cereal plants.

[0026] In another aspect, the present invention provides a fungicidal composition comprising an effective amount as a fungicide of a multi-site fungicide to control zymoseptoria infection in a host legume plant.

[0027] In another aspect, the present invention provides a fungicidal composition comprising an effective amount as a fungicide of a Petition 870260041192, dated 04 / 05 / 2026, page 95 / 172 6 / 77 multisite fungicide to control Septoria leaf spot disease in a host legume plant.

[0028] In another aspect, the present invention provides a fungicidal composition comprising an effective amount as a fungicide of a multi-site fungicide for controlling septoria leaf spot diseases caused by zymoseptoria infection in a host legume plant.

[0029] In another aspect, the present invention provides a fungicidal combination for treating zymoseptoria infection in cereal plants, wherein the combination comprises a first multi-site fungicide and at least one other fungicide selected from a demethylation inhibitor, external quinone inhibitor, succinate dehydrogenase inhibitor, internal quinone inhibitor or combinations thereof.

[0030] In another aspect, the present invention provides a fungicidal combination for treating zymoseptoria infection in cereal plants, wherein the combination comprises captan and at least one other fungicide selected from a demethylation inhibitor, external quinone inhibitor, succinate dehydrogenase inhibitor, internal quinone inhibitor or combinations thereof.

[0031] In another aspect, the present invention provides a fungicidal combination for treating zymoseptoria infection in a host legume plant, wherein the combination comprises a first multisite fungicide and at least one other fungicide selected from a demethylation inhibitor, external quinone inhibitor, succinate dehydrogenase inhibitor, internal quinone inhibitor or combinations thereof. Petition 870260041192, dated 04 / 05 / 2026, page 96 / 172 7 / 77

[0032] In another aspect, the present invention provides a fungicidal composition for the control of Zymoseptoria infection in cereal plants comprising: (i) an effective amount as a fungicide of a multi-site fungicide and (ii) at least one second fungicide is selected from the group consisting of an external quinone inhibitor, an internal quinone inhibitor, a demethylation inhibitor and a succinate dehydrogenase inhibitor.

[0033] In another aspect, the present invention provides a fungicidal composition for the control of Zymoseptoria infection in cereal plants comprising: 1) an effective amount as a captan fungicide and 2) at least one second fungicide is selected from the group consisting of an external quinone inhibitor, an internal quinone inhibitor, a demethylation inhibitor and a succinate dehydrogenase inhibitor.

[0034] In another aspect, the present invention provides a fungicidal composition for controlling zymoseptoria infection in leguminous or cereal host plants comprising: (i) an effective amount as a fungicide of a multi-site fungicide and (ii) at least one second fungicide selected from the group consisting of an external quinone inhibitor, an internal quinone inhibitor, a demethylation inhibitor and a succinate dehydrogenase inhibitor. (iii) at least one third fungicide is selected from the group consisting of an external quinone inhibitor, an internal inhibitor of Petition 870260041192, dated 04 / 05 / 2026, page 97 / 172 8 / 77 quinone, a demethylation inhibitor and a succinate dehydrogenase inhibitor.

[0035] In one embodiment, the first and second systemic fungicides belong to different classes of systemic fungicides.

[0036] In another aspect, the present invention provides the use of a multisite fungicide as a synergist to improve disease control in plants infected with Zymoseptoria when applied subsequently, before or simultaneously with at least one other fungicide selected from among an external quinone inhibitor, an internal quinone inhibitor, a demethylation inhibitor, a succinate dehydrogenase inhibitor or combinations thereof.

[0037] In another aspect, the present invention provides the use of captan as a synergist to improve disease control in plants infected by zymoseptoria and also improve plant productivity.

[0038] In another aspect, the present invention provides a method for treating zymoseptoria infection in a leguminous and / or cereal host plant, comprising: applying to the plant at the site of infection a fungicidal composition of the present invention.

[0039] In one embodiment, a method of treating fungal leaf spot diseases caused by Zymoseptoria in a host legume plant comprises: applying to the plant at the site of infection a fungicidal composition comprising a multi-site fungicide.

[0040] In one embodiment, a method for controlling fungal leaf spot diseases caused by Zymoseptoria in plants comprises: applying to the plant at the site of infection a fungicidal composition comprising a multi-site fungicide and one or more other fungicides. Petition 870260041192, dated 04 / 05 / 2026, p. 98 / 172 9 / 77 BRIEF DESCRIPTION OF THE DRAWINGS:

[0041] Figure 1: Percentage efficacy of the Zymoseptoria tritici Zt strain Tri-R6, moderately resistant to DMI and highly resistant to QoI fungicides, in untreated wheat leaf fragments or those preventively treated with Captan, Chlorothalonil, Sulfur, and Mancozeb under controlled conditions. DETAILED DESCRIPTION OF THE INVENTION

[0042] For the purposes of the detailed description that follows, it should be understood that the invention may assume various variations and alternative sequences of steps, except where expressly specified otherwise. Furthermore, in addition to any operational examples, or where otherwise indicated, all numbers expressing, for example, quantities of materials / ingredients used in the descriptive report, should be understood as being modified in all cases by the term approximately.

[0043] Thus, before describing the present invention in detail, it should be understood that the present invention is not limited to particularly exemplified systems or process parameters, which may, of course, vary. It should also be understood that the terminology used herein is for the purpose of describing specific embodiments of the invention only and is not intended to limit the scope of the invention in any way. The use of examples anywhere in this descriptive report, including examples of any terms discussed herein, is for illustrative purposes only and in no way limits the scope and meaning of the invention or any exemplified term. Similarly, the invention is not limited to the various embodiments presented in this descriptive report. Except where otherwise defined, all technical terms and Petition 870260041192, dated 04 / 05 / 2026, p. 99 / 172 The scientific terms used in the present invention have the same meaning as commonly understood by those skilled in the art to which this invention pertains. In case of conflict, the present document, including the definitions, shall prevail.

[0044] It should be noted that, as used in this descriptive report, the singular forms a, an, and the include plural references, unless the content clearly indicates otherwise. The terms preferred and preferred refer to embodiments of the invention that may provide certain benefits under certain circumstances.

[0045] As used herein, the terms comprising, including, having, containing, involving and the like should be understood as open-ended, that is, to mean that they include, but are not limited to.

[0046] In any aspect or embodiment described below, the expression comprising may be replaced by the expressions consisting of or consisting essentially of or consisting substantially of. In these aspects or embodiment, the combination or composition described includes, comprises or consists of or consists essentially of or consists substantially of the specific components mentioned therein, excluding other fungicides or plant growth promoters, or adjuvants or excipients not specifically mentioned therein.

[0047] It has been surprisingly discovered that the use of a multisite contact fungicide is effective in combating the Zymoseptoria pathogen that moves across plant foliage. Without adhering to theory, it is believed that a multisite contact fungicide has very satisfactory fungicidal efficacy against Zymoseptoria and almost completely inhibits the development of this pathogen in wheat leaf tissues. The same Petition 870260041192, dated 04 / 05 / 2026, pp. 100 / 172 11 / 77 also penetrates dense plant foliage, effectively preventing the pathogen from infecting the remaining portion of the plant and reducing the plant's susceptibility to infection. Additionally, it has also been found that when used in combination with at least one of the other fungicides, it provides unexpected and surprising synergistic fungicidal efficacy.

[0048] In one embodiment, the multisite contact fungicide is selected from captan, captafol, or folpet, or combinations thereof.

[0049] In one embodiment, the multisite contact fungicide is a combination comprising at least one selected from captan, captafol, and folpet, and at least one other multisite contact fungicide, as described herein. In this embodiment, another multisite fungicide is a contact fungicide other than captan, captafol, or folpet.

[0050] In one embodiment, these compositions of the present invention may be especially effective against the Septoria family of fungi.

[0051] For example, the zymoseptoria fungus includes the species Zymoseptoria ardabiliae, Zymoseptoria brevis, Zymoseptoria halophila, Zymoseptoria passerinii, Zymoseptoria pseudotritici, Zymoseptoria tritici and Zymoseptoria verkleyi.

[0052] In one aspect, the present invention provides a fungicidal composition comprising an effective amount as a fungicide of a multi-site contact fungicide to control zymoseptoria infection in a host legume plant.

[0053] In a preferred embodiment, the present invention provides a fungicidal composition comprising an effective amount as a fungicide of a multi-site contact fungicide to control zymoseptoria infection in cereal plants. Petition 870260041192, dated 04 / 05 / 2026, pp. 101 / 172 12 / 77

[0054] According to the invention, the fungicidal composition comprises an effective amount of captan as a fungicide in the composition. The term effective amount denotes an amount of the compositions that is sufficient to control harmful fungi in cultivated plants or in the protection of materials and that does not result in substantial damage to the treated plants. Such an amount may vary over a wide range and depends on several factors, such as the fungal species to be controlled, the plant or cultivated material treated, the climatic conditions and the specific composition used.

[0055] In general, the composition according to the invention may contain from 0.05 to 99% by weight of active compounds, preferably from 10 to 70% by weight.

[0056] In another aspect, the present invention provides a fungicidal composition comprising an effective amount as a fungicide of a multi-site contact fungicide for controlling septoria leaf spot disease in a host legume plant or cereal plants.

[0057] In another aspect, the present invention provides a fungicidal composition comprising an effective amount as a fungicide of a multi-site fungicide for controlling septoria leaf spot diseases caused by zymoseptoria infection in a host legume plant.

[0058] In another aspect, the present invention provides a fungicidal combination for treating zymoseptoria infection in a leguminous host plant, wherein the combination comprises a first multi-site contact fungicide, and at least one other systemic fungicide selected from a demethylation inhibitor, an external quinone inhibitor, an inhibitor of Petition 870260041192, dated 04 / 05 / 2026, pages 102 / 172 13 / 77 succinate dehydrogenase, internal quinone inhibitor or combinations thereof.

[0059] In another aspect, the present invention provides a fungicidal composition for controlling zymoseptoria infection in a leguminous host plant comprising: a) an effective quantity as a fungicide of a multi-site fungicide and b) at least one second fungicide is selected from the group consisting of an external quinone inhibitor, an internal quinone inhibitor, a demethylation inhibitor and a succinate dehydrogenase inhibitor.

[0060] In another aspect, the present invention provides a fungicidal composition for controlling zymoseptoria infection in a leguminous host plant comprising: a) an effective amount as a fungicide of a multi-site contact fungicide and b) at least one second fungicide selected from the group consisting of an external quinone inhibitor, an internal quinone inhibitor, a demethylation inhibitor and a succinate dehydrogenase inhibitor. (c) at least one third fungicide is selected from the group consisting of an external quinone inhibitor, an internal quinone inhibitor, a demethylation inhibitor, and a succinate dehydrogenase inhibitor.

[0061] In another aspect, the present invention provides a fungicidal combination comprising (a) a multisite fungicide, (b) a second fungicide is an external quinone inhibitor; and (c) a third fungicide is a demethylation inhibitor or a succinate dehydrogenase inhibitor. Petition 870260041192, dated 04 / 05 / 2026, pp. 103 / 172 14 / 77

[0062] In another aspect, the present invention provides a fungicidal combination comprising (a) a multisite fungicide, (b) a second fungicide is a demethylation inhibitor; and (c) a third fungicide is selected from the group consisting of an external quinone inhibitor, an internal quinone inhibitor or a succinate dehydrogenase inhibitor.

[0063] In another aspect, the present invention provides a fungicidal combination comprising (a) a multisite fungicide, (b) a second fungicide is a succinate dehydrogenase inhibitor; and (c) a third fungicide is selected from the group consisting of an external quinone inhibitor, an internal quinone inhibitor, or a demethylation inhibitor.

[0064] In another aspect, the present invention provides a fungicidal composition for controlling zymoseptoria infection in a leguminous host plant comprising: a) an effective quantity as a fungicide of a multi-site fungicide and b) at least one external quinone inhibitor.

[0065] In the preferred embodiment, the present invention provides a fungicidal composition for controlling zymoseptoria infection in cereal plants comprising: a) an effective amount as a fungicide of a multi-site fungicide and b) at least one external quinone inhibitor.

[0066] In another aspect, the present invention provides a fungicidal composition for controlling zymoseptoria infection in a leguminous host plant comprising: Petition 870260041192, dated 04 / 05 / 2026, pp. 104 / 172 15 / 77 a) an effective amount as a fungicide of a multi-site fungicide and b) at least one internal quinone inhibitor.

[0067] In another aspect, the present invention provides a fungicidal composition for controlling zymoseptoria infection in a leguminous host plant comprising: a) an effective amount as a fungicide of a multi-site fungicide and b) at least one demethylation inhibitor.

[0068] In another aspect, the present invention provides a fungicidal composition for controlling zymoseptoria infection in a leguminous host plant comprising: a) an effective amount as a fungicide of a multi-site fungicide and b) at least one succinate dehydrogenase inhibitor.

[0069] In another aspect, the present invention provides a fungicidal composition for controlling zymoseptoria infection in a leguminous host plant comprising: a) an effective amount as a fungicide of a multi-site fungicide and b) at least one internal quinone inhibitor, c) at least one demethylation inhibitor.

[0070] In another aspect, the present invention provides a fungicidal combination comprising a combination of a multi-site contact fungicide, preferably phthalimide fungicides, together with a systemic fungicide selected from at least one Qo inhibitor (external quinone inhibitors), at least one Qi inhibitor (internal inhibitor of Petition 870260041192, dated 04 / 05 / 2026, pages 105 / 172 16 / 77 quinone), at least one DM inhibitor (demethylation inhibitor) or at least one SDH inhibitor (succinate dehydrogenase inhibitors).

[0071] The multi-site contact fungicides of the present invention inhibit fungal growth through multiple sites of action and have both contact and preventative activities.

[0072] In one embodiment, the multisite contact fungicide is selected from folpet, captan or captafol or combinations thereof.

[0073] In one embodiment, the multisite contact fungicide is captan.

[0074] In one embodiment, the multisite contact fungicide is a combination comprising one of captan, folpet, or captafol; and at least one other multisite contact fungicide, as described herein. In this embodiment, the second multisite fungicide is a contact fungicide other than captan, folpet, or captafol.

[0075] The term systemic fungicide, for use in the present invention, should denote a fungicide that is absorbed into plant tissue and possesses at least some amount of post-infection activity. Preferably, the systemic fungicide of the present invention is capable of moving freely throughout the plant. However, the term systemic fungicide is intended to include, in the present invention, ascending systemic fungicide as well as locally acting systemic fungicide.

[0076] In one embodiment, the second multi-site contact fungicide is selected from: (i) copper fungicides selected from copper oxychloride, copper sulfate3Λ, copper hydroxide and tribasic copper sulfate (or Bordeaux mixture); (ii) elemental sulfur; Petition 870260041192, dated 04 / 05 / 2026, pages 106 / 172 17 / 77 (iii) dithiocarbamate fungicides selected from amobam, asomate, azitiram, carbamorf, cufraneb, cuprobam, disulfiram, ferbam, metam, nabam, tecoram, thiram, urbacida, ziram, dazomet, etem, milneb, mancopper, mancozeb, maneb, metiram, polycarbamate, propineb and zineb; (iv) chlorothalonil; (v) sulfonamide fungicides selected from diclofluanide and tolylfluanide; (vi) guanidine fungicides selected from dodine, guazantine t3a and iminoctadine; (vii) anilazine; dithianone; and combinations thereof.

[0077] In one embodiment, the external quinone inhibitor is selected from the group consisting of fenamidone, famoxadone and a strobilurin fungicide selected from the group consisting of azoxystrobin, mandestrobin, cumoxystrobin, enoxastrobin, flufenoxystrobin, pyroxystrobin, dimoxystrobin, enestrobin, fluoxastrobin, cresoxima-methyl, metominostrobin, orisastrobin, picoxystrobin, pyrametostrobin, triclopiricarb, fenaminstrobin, pyraclostrobin and trifloxystrobin;(b) o inibidor de desmetilação é selecionado do grupo que consiste em triflumizol, triforina, piridinitrila, pirifenox, fenarimol, nuarimol, triarimol e um fungicida conazol selecionado do grupo que consiste em climbazol, clotrimazol, imazalil, oxpoconazol, procloraz, procloraz-manganês, triflumizol, azaconazol, bitertanol, bromuconazol, ciproconazol, diclobutrazol, difenoconazol, diniconazol, diniconazol-M, epoxiconazol, etaconazol, fenbuconazol, fluotrimazol, fluquinconazol, flusilazol, flutriafol, furconazol, furconazol-cis, hexaconazol, imibenconazol, ipconazol, metconazol, miclobutanil,; Petição 870260041192, de 04 / 05 / 2026, pág. 107 / 172 18 / 77 pencoconazol, propiconazol, protioconazol, quinconazol, simeconazol, tebuconazol, tetraconazol, triadimefona, triadimenol, triticonazol, uniconazol, perfurazoato e uniconazol-P.

[0078] In one embodiment, the internal quinone inhibitor includes cyanoimidazole fungicides and sulfamoyltriazole fungicides, selected from cyazofamide and amisulbrom.

[0079] In one embodiment, the external quinone inhibitor includes a strobilurin fungicide.

[0080] In this embodiment, the MD inhibitor is, preferably, a conazole fungicide selected from the group consisting of climbazole, clotrimazole, imazalil, oxpoconazole, prochloraz, prochloraz-manganese, triflumizole, azaconazole, bitertanol, bromuconazole, cyproconazole, diclobutrazol, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, etaconazole, fenbuconazole, fluotrimazole, fluquinconazole, flusilazole, flutriafol, furconazole, furconazole-cis, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, pencoconazole, propiconazole, prothioconazole, quinconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, uniconazole, perforazoate and uniconazole-P.

[0081] In one embodiment, the succinate dehydrogenase inhibitor is selected from the group consisting of benodanil, flutolanil, mepronil, fluopyram, fenfuran, carboxin, oxycarboxin, tifluzamide, bixafen, fluxapyroxad, furamethpir, isopyrasam, penflufen, penthiopyrad, sedaxane and boscalid and combinations thereof.

[0082] In one embodiment, the systemic fungicide may be selected from the group consisting of a strobilurin fungicide, a conazole fungicide, and a succinate dehydrogenase inhibitor; wherein Petition 870260041192, dated 04 / 05 / 2026, pp. 108 / 172 19 / 77 (a) the strobilurin fungicide is selected from the group consisting of fluoxastrobin, mandestrobin, piribencarb; methoxyacrylate strobilurin fungicides selected from azoxystrobin, bifujunzhi, cumoxystrobin, enoxastrobin, flufenoxystrobin, jiaxiangjunzhi, picoxystrobin, piraoxystrobin; methoxycarbanylate strobilurin fungicides selected from pyraclostrobin, pyrametostrobin, triclopiricarb; methoxyiminoacetamide strobilurin fungicides selected from dimoxystrobin, phenaminstrobin, metominostrobin, orisastrobin; methoxyiminoacetate strobilurin fungicides selected from cresoxima-methyl, trifloxystrobin; (b) o fungicida de conazol é selecionado do grupo que consiste em climbazol, clotrimazol, imazalil, oxpoconazol, procloraz, proclorazmanganês, triflumizol, azaconazol, bitertanol, bromuconazol, ciproconazol, diclobutrazol, difenoconazol, diniconazol, diniconazol-M, epoxiconazol, etaconazol, fenbuconazol, fluotrimazol, fluquinconazol, flusilazol, flutriafol, furconazol, furconazol-cis, hexaconazol, imibenconazol, ipconazol, metconazol, miclobutanil, pencoconazol, propiconazol, protioconazol, quinconazol, simeconazol, tebuconazol, tetraconazol, triadimefon, triadimenol, triticonazol, uniconazol, perfurazoato e uniconazol-P;and (c) the succinate dehydrogenase inhibitor is selected from (i) benzanilide fungicides selected from benodanil, flutolanil, mebenil, mepronil, salicylanilide, tecloftalam (ii) benzamide fungicides selected from benzohydroxamic acid, fluopicolide, fluopimomide, fluopyram, thioximide, triclamide, zarilamide, zoxamide, and oxathiin fungicides selected from carboxin and oxycarboxin; Petition 870260041192, dated 04 / 05 / 2026, pp. 109 / 172 20 / 77 (iii) thiazole fungicides selected from diclobenthiazox, etaboxame, fluoxapiproline, isotianil, metsulfovax, octilinone, oxathiapiproline, thiabendazole, tifluzamide (iv) pyrazolecarboxamide fungicides selected from the group consisting of benzovindiflupyr, bixafen, fluindapyr, fluxapyroxad, furametippyr, isopyrazame, penflufene, penthiopyrad, pidiflumethofen, pirapropoin, sedaxane, fluxapyroxad, isopyrazame and boscalid. (v) Anilide fungicides selected from benalaxyl, benalaxyl-M, bixafen, boscalid, carboxin, fenexamide, fluxapyroxad, isotianil, metalaxyl, metalaxyl-M, metsulfovax, ofurace, oxadixil, oxycarboxin, penflufen, piracarbolide, pyraziflumide, sedaxane, tifluzamide, thiadinil, vanguard (vi) Pyrazolecarboxamide fungicides selected from benzovindiflupyr, bixafen, fluindapyr, fluxapyroxad, furamethpyr, isopyrazam, penflufen, penthiopyrad, pidiflumethophene, pirapropoin, sedaxane

[0083] It was found that a combination of a multisite contact fungicide, preferably at least one phthalamide fungicide, together with a systemic fungicide selected from at least one Qo inhibitor (Qo inhibitors) external quinone), at least one Qi inhibitor (internal quinone inhibitor),At least one DM inhibitor (demethylation inhibitor) or at least one SDH inhibitor (succinate dehydrogenase inhibitor) induces an unexpected and surprisingly satisfactory control of Zymoseptoria tritici.

[0084] In one embodiment, the multi-site contact fungicide is selected from folpet, captan, or captafol.

[0085] In one embodiment, the multi-site contact fungicide is captan. Petition 870260041192, dated 04 / 05 / 2026, pages 110 / 172 21 / 77

[0086] In one embodiment, the multisite contact fungicide is a combination comprising at least one of captan, folpet, or captafol; and at least one other multisite contact fungicide, as described herein. In this embodiment, the second multisite fungicide is a contact fungicide other than captan, folpet, or captafol.

[0087] In one embodiment, the multisite fungicide in the combination is captan and the systemic fungicide is fluxapyroxad.

[0088] In one embodiment, the multisite fungicide is captan, folpet, or captafol; and the systemic fungicide is a combination comprising fluxapyroxad and prothioconazole.

[0089] In one embodiment, the multisite fungicide is captan; and the systemic fungicide is a combination comprising fluxapyroxad and prothioconazole.

[0090] In one embodiment, the multisite fungicide is captan, folpet or captafol; and the systemic fungicide is prothioconazole.

[0091] In one embodiment, the multisite fungicide is captan; and the systemic fungicide is prothioconazole.

[0092] In one embodiment, the multisite contact fungicide is chlorotenil and a phthalimide fungicide is selected from folpet, captan, or captafol.

[0093] In one embodiment, the multi-site contact fungicide is a combination comprising captan and chlorothalonil.

[0094] In one embodiment, the multisite contact fungicide is a combination comprising one of captan, folpet or captafol; and chlorothalonil. Petition 870260041192, dated 04 / 05 / 2026, pages 111 / 172 22 / 77

[0095] In one embodiment, the multisite fungicide is a combination comprising chlorothalonil and one of captan, folpet, or captafol; and the systemic fungicide is fluxapyroxad.

[0096] In one embodiment, the multisite fungicide is a combination comprising chlorothalonil and captan and the systemic fungicide is fluxapyroxad.

[0097] In one embodiment, the multisite fungicide is a combination comprising chlorothalonil and one of captan, folpet, or captafol; and the systemic fungicide is a combination comprising fluxapyroxad and prothioconazole.

[0098] In one embodiment, the multisite fungicide is a combination comprising chlorothalonil and captan; and the systemic fungicide is a combination comprising fluxapyroxad and prothioconazole.

[0099] In one embodiment, the multisite fungicide is a combination comprising chlorothalonil and one of captan, folpet, or captafol; and the systemic fungicide is prothioconazole.

[0100] In one embodiment, the multisite fungicide is a combination comprising chlorothalonil and captan; and the systemic fungicide is prothioconazole.

[0101] In one embodiment, the multisite fungicide is captan, folpet or captafol; and the systemic fungicide is fluoxapyroxad.

[0102] In one embodiment, the multisite fungicide is captan, folpet or captafol; and the systemic fungicide is penthiopyrad.

[0103] In one embodiment, the multisite fungicide is captan, folpet or captafol; and the systemic fungicide is bixafen.

[0104] In one embodiment, the multisite fungicide is captan, folpet or captafol; and the systemic fungicide is fluindapyr. Petition 870260041192, dated 04 / 05 / 2026, pages 112 / 172 23 / 77

[0105] In one embodiment, the multisite fungicide is captan, folpet or captafol; and the systemic fungicide is benzovindiflupir.

[0106] In one embodiment, the multisite fungicide is captan, folpet or captafol; and the systemic fungicide is prothioconazole.

[0107] In one embodiment, the multisite fungicide is captan, folpet or captafol; and the systemic fungicide is tetraconazole.

[0108] In one embodiment, the multisite fungicide is at least one selected from captan, folpet, or captafol; and the systemic fungicide is difenoconazole.

[0109] In one embodiment, the composition comprises at least one fungicide selected from captan, folpet or captafol; and difenoconazole, which further comprises sulfur.

[0110] In one embodiment, the multisite fungicide is captan, folpet or captafol; and the systemic fungicide is fluoxastrobin.

[0111] In one embodiment, the multisite fungicide is captan, folpet or captafol; and the systemic fungicide is azoxystrobin.

[0112] In one embodiment, the multisite fungicide is a combination comprising copper and one of captan, folpet, or captafol.

[0113] In one embodiment, the multisite fungicide is a combination comprising sulfur and one of captan, folpet, or captafol.

[0114] In one embodiment, the multisite fungicide is mancozeb, and one of them is captan, folpet, or captafol.

[0115] In the preferred embodiment, the multisite fungicide is selected from captan, folpet or captafol.

[0116] In one embodiment, the multisite fungicide is a combination of captan, folpet or captafol with a second multisite fungicide. Petition 870260041192, dated 04 / 05 / 2026, pages 113 / 172 24 / 77

[0117] In one embodiment, the second multisite fungicide is selected from the group consisting of dithiocarbamates, chloronitriles, inorganic fungicides, sulfonamides, bis-guanidines, triazines, quinones, quinoxalines, dicarboxamides and mixtures thereof.

[0118] In one embodiment, the second multisite fungicide is selected from the class of dithiocarbamate fungicides selected from asamobam, asomate, azitiram, carbamorf, cufraneb, cuprobam, disulfiram, ferbam, metame, nabame, tecoram, tirame, urbacida, ziram, dazomete, etem, milneb, mancopper, mancozeb, maneb, metiram, polycarbamate, propineb and zineb.

[0119] In one embodiment, the second multisite fungicide is a chloronitrile fungicide, such as chlorothalonil.

[0120] In one embodiment, the second multisite fungicide is a sulfonamide fungicide selected from diclofluanide and tolylfluanide.

[0121] In one embodiment, the second multisite fungicide is a bis-guanidine fungicide selected from guazatine and iminoctadine.

[0122] In one embodiment, the second multisite fungicide is a triazine fungicide selected from anilazine.

[0123] In one embodiment, the second multisite fungicide is a quinone fungicide selected from dithianone.

[0124] In one embodiment, the second multisite fungicide is a quinoxaline fungicide selected from quinomethionate and chlorquinox.

[0125] In one embodiment, the second multisite fungicide is a dicarboxamide fungicide selected from among fluoroimides.

[0126] In one embodiment, the second multisite fungicide is an inorganic fungicide selected from copper fungicides, including copper(II) hydroxide, copper oxychloride, copper(II) sulfate, Petition 870260041192, dated 04 / 05 / 2026, pp. 114 / 172 25 / 77 basic copper, Bordeaux mixture, copper salicylate C7H4O3*Cu, cuprous oxide CU2O; or sulfur.

[0127] In one embodiment, the combination of the present invention comprises at least one systemic fungicide in addition to the multisite fungicide or combinations thereof.

[0128] In a preferred embodiment, the composition comprises a combination of at least one fungicide selected from captan, folpet or captafol and sulfur.

[0129] In one embodiment, the systemic fungicide is a combination of at least two other systemic fungicides. In this embodiment, these systemic fungicides are referred to in the present invention as the second and third fungicides, respectively. However, the second and third fungicides are never the same fungicides, although they may be a combination of two fungicides from the same class of fungicides.

[0130] In one embodiment, the second and / or third fungicide in the combinations of the present invention may be individually selected from among nucleic acid synthesis inhibitors, motor protein and cytoskeleton inhibitors, protein and amino acid synthesis inhibitors, respiration process inhibitors, signal transduction inhibitors, lipid synthesis and membrane integrity disruptors, sterol biosynthesis inhibitors, melanin synthesis inhibitors, cell wall biosynthesis inhibitors, host plant defense inducers and / or fungicides with unknown modes of action.

[0131] Thus, in one embodiment, the nucleic acid synthesis inhibitor fungicide may be selected from among acylalanines, such as benalaxyl, benalaxyl-M (chiralaxyl), furalaxyl, metalaxyl, metalaxyl-M (mefenoxame), oxazolidinones, such as oxadixyl, butyrolactones, such as Petition 870260041192, dated 04 / 05 / 2026, pages 115 / 172 26 / 77 ofurace, hydroxy-(2-amino-)pyrimidines, such as bupirimate, dimethylimolene, ethyrimone, isoxazoles, such as himexazole, isothiazolines, such as octilinone, carboxylic acids, such as oxolinic acid.

[0132] In one embodiment, motor and cytoskeletal protein inhibitors may be benzimidazoles, such as benomyl, carbendazim, fuberidazole, thiabendazole; thiophanates, such as thiophanate, thiophanate-methyl; N-phenyl carbamates, such as dietofencarb; toluamides, such as zoxamide; thiazole carboxamides, such as etaboxame; phenylureas, such as pencicurone; benzamides, such as fluopicolide; cyanoacrylates, such as fenamacryl.

[0133] In one embodiment, fungicides that inhibit the respiration process can be selected from among pyrimidinamines such as diflumetorim; pyrazole-5-carboxamides such as tolfenpyrad; strobilurins such as azoxystrobin, cumoxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, pyroxystrobin, mandestrobin, pyraclostrobin, pyrametostrobin, triclopiricarb, kresoxim-methyl, dimoxystrobin, phenaminostrobin, metominostrobin, trifloxystrobin, famoxadone, fluoxastrobin, fenamidone, piribencarb and mixtures thereof; oxazolidinediones, such as famoxadone; imidazolinones, such as fenamidone; benzylcarbamates, such as piribencarb; N-methoxy-(phenylethyl)-pyrazolecarboxamides, such as pyrimidinamines, such as diflumetorim; cyanoimidazole, such as ciazofamide; sulfamoyltriazole, such as amisulbrom; dinitrophenyl crotonates, such as binapacryl; meptildinocap, dinocap; 2,6-dinitroanilines, such as fluazinam; pyr.-hydrazones, such as ferimzone; triphenyltin compounds, such as fentin acetate, fentin chloride, fentin hydroxide; thiophenecarboxamides, such as silthiofam; triazolopyrimidylamine, such as amethoctradine. Petition 870260041192, dated 04 / 05 / 2026, pages 116 / 172 27 / 77

[0134] In one embodiment, protein and amino acid synthesis inhibiting fungicides may be selected from among anilinopyrimidines, such as cyprodinil, mepanipyrim, pyrimethanil, antibiotic fungicides, such as blasticidin-S, kasugamycin, streptomycin, oxytetracycline and the like.

[0135] In one embodiment, signal transduction inhibitor fungicides may be selected from among aryloxyquinolines such as quinoxifene; quinazolinones such as proquinazide; phenylpyrroles such as fenpiclonil, fludioxonil; dicarboximides such as clozolinate, dimethaclone, iprodione, procymidone and vinclozolin.

[0136] In one embodiment, the fungicide may be selected from disruptors of lipid synthesis and membrane integrity, such as phosphorothiolates, such as edifenfos, iprobenfos, pyrazofos; dithiolanes, such as isoprothiolan; aromatic hydrocarbons, such as biphenyl, chloroneb, dichlorane, quintozene (PCNB), tecnazene (TCNB), tolclofos-methyl and the like; 1,2,4-thiadiazoles, such as etridiazole; carbamates, such as iodocarb, propamocarb, prothiocarb and the like.

[0137] Thus, in one embodiment, sterol biosynthesis inhibitors may be selected from triazoles such as azaconazole, bitertanol, bromuconazole, ciproconazole, difenoconazole, diniconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, penconazole, propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, prothioconazole, piperazines, such as triforin; pyridines, such as pirifenox, pirisoxazole; pyrimidines, such as fenarimol, nuarimol; imidazoles, such as imazalil, oxpoconazole, pefurazoate, prochloraz, triflumizole; Morpholines, such as aldimorph, dodemorph, fenpropimorph, tridemorph and similar compounds; piperidines, such as Petition 870260041192, dated 04 / 05 / 2026, pages 117 / 172 28 / 77 phenpropidine, piperaline; spirocetal-amines, such as spiroxamine; hydroxyanilides, such as phenexamide; aminopyrazolinones, such as fenpyrazamine; thiocarbamates, such as piributicarb; allylamines, such as naftifine, terbinafine and mixtures thereof.

[0138] In one embodiment, cell wall biosynthesis inhibiting fungicides may be selected from among peptidyl-pyrimidine nucleoside fungicides, such as polyoxin, cinnamic acid amides, such as dimethomorph, flumorph, pirimorph; valinamide carbamates, such as bentiavalicarb, iprovalicarb, valifenalate; mandelic acid amides, such as mandipropamide and mixtures thereof.

[0139] In one embodiment, the melanin synthesis inhibitor fungicide may be selected from among isobenzo-furanone, such as phthalide; pyrroloquinolinones, such as pyroquilone; triazolobenzo-thiazoles, such as tricyclazole; cyclopropane-carboxamides, such as carpropamide; carboxamides, such as diclocimet; propionamides, such as fenoxanil; trifluoroethyl-carbamates, such as tolprocarb; and mixtures thereof.

[0140] In one embodiment, fungicides that induce host plant defense may be selected from among benzo-thiadiazoles, such as acibenzolar-S-methyl; benzisothiazoles, such as probenazole; thiadiazolecarboxamides, such as thiadinyl, isothianyl; polysaccharides, such as laminarin; and mixtures thereof.

[0141] In one embodiment, the second or third additional fungicide is a fungicide with an unknown mode of action and may be selected from cyanoacetamide oximes, such as cymoxanil; ethyl phosphonates, such as fostil-Al, phosphorous acid and salts; phthalamic acids, such as tecloftalam; benzotriazines, such as triazoxide; benzenesulfonamides, such as flusulfamide; pyridazinones, such as diclomezine; thiocarbamates, such as Petition 870260041192, dated 04 / 05 / 2026, pages 118 / 172 29 / 77 metasulfocarb; phenylacetamides, such as ciflufenamide; arylphenyl ketones, such as metrafenone, pyriophenone; guanidines, such as dodine; cyanomethylenethiazolidines, such as flutianil; pyrimidinone hydrazones, such as ferimzone; piperidinyl thiazol isoxazolines, such as oxathiapiproline; 4-quinolyl acetates, such as tebufloquine; tetrazoliloximes, such as picarbutrazox; glucopyranosyl antibiotics, such as validamycin; fungicides, such as mineral oil, organic oils, potassium bicarbonate and mixtures thereof.

[0142] In a preferred embodiment, the second fungicide in the combinations of the present invention may be individually selected from among ergosterol biosynthesis inhibitors and external quinone (Qo) inhibitors.

[0143] In another embodiment, the second fungicide of the present invention is a succinate dehydrogenase inhibitor (SDHI) fungicide. Preferably, the succinate dehydrogenase inhibitor is selected from the group consisting of benodanil, flutolanil, mepronil, fluopyram, fenfuran, carboxin, oxycarboxin, tifluzamide, bixafen, fluxapyroxad, furamethpyr, isopyrasam, penflufen, penthiopyrad, sedaxane and boscalid.

[0144] In another preferred embodiment, the second fungicide and the third fungicide in the combinations of the present invention may be ergosterol biosynthesis inhibitors and quinone (Qo) external inhibitors, respectively.

[0145] Ergosterol biosynthesis inhibitors can be selected from the group consisting of azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, Ipconazole, metconazole, myclobutanil, penconazole, Propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, prothioconazole, Petition 870260041192, dated 04 / 05 / 2026, pages 119 / 172 30 / 77 imazalil, oxpoconazole, pefurazoate, prochloraz, triflumizole, fenarimol, nuarimol, pyrifenox, pyrisoxazole and triforin.

[0146] In another embodiment, ergosterol biosynthesis inhibitors may be selected from prothioconazole, tebuconazole, hexaconazole, ciroconazole or epoxiconazole.

[0147] In one embodiment, the third fungicide may be an external quinone (Qo) inhibitor fungicide selected from azoxystrobin, cumoxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, pyroxystrobin, mandestrobin, pyraclostrobin, pyrametostrobin, triclopiricarb, cresoxim-methyl, dimoxystrobin, phenaminostrobin, metominostrobin, trifloxystrobin, famoxadone, fluoxastrobin, fenamidone and piribencarb.

[0148] In one embodiment, the quinone (Qo) external inhibitor fungicide may be selected from azoxystrobin, picoxystrobin, kresoxymethyl, pyraclostrobin and trifloxystrobin.

[0149] In one embodiment, the second and third fungicides of the present invention may be selected from a strobilurin fungicide and a conazole fungicide, respectively.

[0150] In another embodiment, the second and third fungicides may be selected from a strobilurin fungicide and a succinate dehydrogenase inhibitor fungicide, respectively.

[0151] In yet another embodiment, the second and third fungicides may be selected from a conazole fungicide and a succinate dehydrogenase inhibitor fungicide, respectively.

[0152] In these modalities: The succinate dehydrogenase inhibitor fungicide can be selected from the group consisting of benodanil, flutolanil, mepronil, Petition 870260041192, dated 04 / 05 / 2026, pages 120 / 172 31 / 77 fluopiram, fenfuran, carboxin, oxycarboxin, tifluzamide, bixafen, fluxapyroxad, furamethpyr, isopyrazam, penflufen, penthiopyrad, sedaxan and boscalid; or the succinate dehydrogenase inhibitor fungicide may preferably be selected from the group consisting of tifluzamide, bixafen, fluxapyroxad, isopyrazam, penthiopyrad, sedaxan and boscalid; or the conazole fungicide may be selected from the group consisting of azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, Ipconazole, metconazole, myclobutanil, penconazole, propiconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, prothioconazole, imazalil, oxpoconazole, pefurazoate, prochloraz, triflumizole, fenarimol, nuarimol, pyrifenox, pyrisoxazole and triforin;or the conazole fungicide may preferably be selected from the group consisting of prothioconazole, tebuconazole, hexaconazole, ciroconazole or epoxiconazole; or the strobilurin fungicide may be selected from the group consisting of azoxystrobin, cumoxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, pyroxystrobin, mandestrobin, pyraclostrobin, pyrametostrobin, triclopiricarb, cresoxime-methyl, dimoxystrobin, phenaminostrobin, metominostrobin, trifloxystrobin, famoxadone, fluoxastrobin, fenamidone and piribencarb; or the strobilurin fungicide may preferably be selected from the group consisting of azoxystrobin, picoxystrobin, cresoxime-methyl, pyraclostrobin and trifloxystrobin. Petition 870260041192, dated 04 / 05 / 2026, pages 121 / 172 32 / 77

[0153] In one embodiment, the combinations of the present invention include the following preferred combinations.

[0154] In the example combinations organized below, the term Fungicide A means at least one, and preferably each individually, of the fungicides selected from mancozeb (A1), sulfur (A2), copper salt, for example, tribasic copper sulfate (TBCS (A3)) or chlorothalonil (A4), as being specifically combined in the present invention with the remaining agrochemicals.

[0155] In the exemplary combinations set out below, the term fungicide B means at least one and preferably each of the fungicides selected from captan (B1), folpet (B2) or captafol (B3) as being specifically combined herein with the other fungicides.

[0156] In the example combinations organized below, the term Fungicide C means at least one, and preferably each individually, of the fungicides selected from cyproconazole (C1), difenoconazole (C2), epoxiconazole (C3), hexaconazole (C4), tebuconazole (C5), tetraconazole (C6), prothioconazole (C7), metalaxyl (C8), metalaxyl-M (C9), benomyl (C10), carbendazim (C11), thiophanate-methyl (C12), zoxamide (C13), fluopicolide (C14), fenamacryl (C15), cyazofamide (C16), amisulbrom (C17), tricyclazole (C18), oxathiapiproline (C19) and picarbutrazox (C20).

[0157] In the example combinations organized below, the term Fungicide D means at least one, and preferably each individually, of the fungicides selected from azoxystrobin (D1), picoxystrobin (D2), pyraclostrobin (D3), cresoxima-methyl (D4), trfloxystrobin (D5), cyproconazole (D6), difenoconazole (D7), hexaconazole (D8), epoxiconazole (D9), tebuconazole (D10), tetraconazole (D11), Petition 870260041192, dated 04 / 05 / 2026, pages 122 / 172 33 / 77 prothioconazole (D12), benomyl (D13), carbendazim (D14), tifanato-methyl (D15), zoxamide (D16), fluopicolide (D17), fenamacryl (D18), ciazofamide (D19), amisulbrom (D20), tricyclazole (D21), oxathiapiproline (D22), picarbutrazox (D23), metalaxyl (D24) and metalaxyl-M (D25).

[0158] In one embodiment, the present compositions comprise a mixture of Fungicide (B) with Fungicide (C), or a mixture of Fungicide (B) with Fungicide (D).

[0159] In an exemplary embodiment, the combination of Fungicide (B) with another fungicide is represented in the tables below. S No. ABCD 1 Fungicide A Fungicide B Cyproconazol - 2 Fungicide A Fungicide B Difenoconazol - 3 Fungicide A Fungicide B Epoxiconazol - 4 Fungicide A Fungicide B Hexaconazol - 5 Fungicide A Fungicide B Tebuconazol - 6 Fungicide A Fungicide B Tetraconazol - 7 Fungicide A Fungicide B Prothioconazol - 8 Fungicide A Fungicide B - Azoxystrobin 9 Fungicide A Fungicide B - Picoxystrobin 10 Fungicide A Fungicide B - Pyraclostrobin 11 Fungicide A Fungicide B - Cresoxim-methyl 12 Fungicide A Fungicide B - Trifloxystrobin 13 Fungicide A Fungicide B Cyproconazol Azoxystrobin 14 Fungicide A Fungicide B Cyproconazol Picoxystrobin 15 Fungicide A Fungicide B Cyproconazol Pyraclostrobin 16 Fungicide A Fungicide B Cyproconazol Cresoxim-methyl 17 Fungicide A Fungicide B Cyproconazol Trifloxystrobin 18 Fungicide A Fungicide B Difenoconazol Azoxystrobin 19 Fungicide A Fungicide B Difenoconazol Picoxystrobin Petition 870260041192, dated 04 / 05 / 2026, pág. 123 / 172 34 / 77 20 Fungicide A Fungicide B Difenoconazole Pyraclostrobin 21 Fungicide A Fungicide B Difenoconazole Cresoxim-methyl 22 Fungicide A Fungicide B Difenoconazole Trifloxystrobin 23 Fungicide A Fungicide B Epoxiconazole Azoxystrobin 24 Fungicide A Fungicide B Epoxiconazole Picoxystrobin 25 Fungicide A Fungicide B Epoxiconazole Pyraclostrobin 26 Fungicide A Fungicide B Epoxiconazole Cresoxim-methyl 27 Fungicide A Fungicide B Epoxiconazole Trifloxystrobin 28 Fungicide A Fungicide B Hexaconazole Azoxystrobin 29 Fungicide A Fungicide B Hexaconazole Picoxystrobin 30 Fungicide A Fungicide B Hexaconazole Pyraclostrobin 31 Fungicide A Fungicide B Hexaconazole Cresoxim-methyl 32 Fungicide A Fungicide B Hexaconazole Trifloxystrobin 33 Fungicide A Fungicide B Tebuconazole Azoxystrobin 34 Fungicide A Fungicide B Tebuconazole Picoxystrobin 35 Fungicide A Fungicide B Tebuconazole Pyraclostrobin 36 Fungicide A Fungicide B Tebuconazole Cresoxim-methyl 37 Fungicide A Fungicide B Tebuconazole Trifloxystrobin 38Fungicide A Fungicide B Tetraconazole Azoxystrobin 39 Fungicide A Fungicide B Tetraconazole Picoxystrobin 40 Fungicide A Fungicide B Tetraconazole Pyraclostrobin 41 Fungicide A Fungicide B Tetraconazole Cresoxim-methyl 42 Fungicide A Fungicide B Tetraconazole Trifloxystrobin 43 Fungicide A Fungicide B Prothioconazole Azoxystrobin 44 Fungicide A Fungicide B Prothioconazole Picoxystrobin 45 Fungicide A Fungicide B Prothioconazole Pyraclostrobin 46 Fungicide A Fungicide B Prothioconazole Cresoxim-methyl 47 Fungicide A Fungicide B Prothioconazole Trifloxystrobin 48 Fungicide A Fungicide B Metalaxyl - 49 Fungicide A Fungicide B Metalaxyl-m - 50 Fungicide A Fungicide B Benomyl - 51 Fungicide A Fungicide B Carbendazim - Petition 870260041192, dated 04 / 05 / 2026, pages 124 / 172 35 / 77 52 Fungicide A Fungicide B Thiophanate-methyl - 53 Fungicide A Fungicide B Zoxamide - 54 Fungicide A Fungicide B Fluopicolide - 55 Fungicide A Fungicide B Fenamacril - 56 Fungicide A Fungicide B Ciazofamide - 57 Fungicide A Fungicide B Amisulbrom - 58 Fungicide A Fungicide B Tricyclazole - 59 Fungicide A Fungicide B Oxathiapiproline - 60 Fungicide A Fungicide B Picarbutrazox - 61 Fungicide A Fungicide B Metalaxyl / MetalaxylM Cyproconazole 62 Fungicide A Fungicide B Metalaxyl / MetalaxylM Difenoconazole 63 Fungicide A Fungicide B Metalaxyl / MetalaxylM Epoxiconazole 64 Fungicide A Fungicide B Metalaxyl / MetalaxylM Hexaconazole 65 Fungicide A Fungicide B Metalaxyl / MetalaxylM Tebuconazole 66 Fungicide A Fungicide B Metalaxyl / MetalaxylM Tetraconazole 67 Fungicide A Fungicide B Metalaxyl / MetalaxylM Prothioconazole 68 Fungicide A Fungicide B Metalaxyl / MetalaxylM Azoxystrobin 69 Fungicide A Fungicide B Metalaxil / MetalaxilM Picoxystrobin 70 Fungicide A Fungicide B Metalaxil / MetalaxilM Pyraclostrobin 71Fungicide A Fungicide B Metalaxyl / MetalaxylM Cresoxim-methyl 72 Fungicide A Fungicide B Metalaxyl / MetalaxylM Benomyl 73 Fungicide A Fungicide B Metalaxyl / MetalaxylM Carbendazim Petition 870260041192, dated 04 / 05 / 2026, pages 125 / 172 36 / 77 74 Fungicide A Fungicide B Metalaxil / MetalaxilM Thiophanate methyl 75 Fungicide A Fungicide B Metalaxil / MetalaxilM Zoxamida 76 Fungicide A Fungicide B Metalaxil / MetalaxilM Fluopicolida 77 Fungicide A Fungicide B Metalaxil / MetalaxylM Phenamacril 78 Fungicide A Fungicide B Metalaxil / MetalaxilM Cyazofamide 79 Fungicide A Fungicide B Metalaxil / MetalaxilM Amissulbrome 80 Fungicide A Fungicide B Metalaxil / MetalaxilM Triciclazol 81 Fungicide A Fungicide B Metalaxil / MetalaxilM Oxatiapiproline 82 Fungicide A Fungicide B Metalaxil / MetalaxilM Picarbutrazox 83 Fungicide A Fungicide B Benomyla Ciproconazol 84 Fungicide A Fungicide B Benomyla Difenoconazol 85 Fungicide A Fungicide B Benomyla Epoxiconazol 86 Fungicide A Fungicide B Benomyla Hexaconazol 87 Fungicide A Fungicide B Benomyla Tebuconazol 88 Fungicide A Fungicide B Benomyla Tetraconazol 89 Fungicide A Fungicide B Benomyla Prothioconazol 90 Fungicide A Fungicide B Benomyla Azoxystrobin 91 Fungicide A Fungicide B Benomyla Picoxystrobin 92Fungicide A Fungicide B Benomyl Pyraclostrobin 93 Fungicide A Fungicide B Benomyl Cresoxim-methyl 94 Fungicide A Fungicide B Benomyl Metalaxyl / MetalaxylM 95 Fungicide A Fungicide B Benomyl Carbendazim 96 Fungicide A Fungicide B Benomyl Thiophanate-methyl 97 Fungicide A Fungicide B Benomyl Zoxamide 98 Fungicide A Fungicide B Benomyl Fluopicolide Petition 870260041192, dated 04 / 05 / 2026, pages 126 / 172 37 / 77 99 Fungicide A Fungicide B Benomyl Fenamacril 100 Fungicide A Fungicide B Benomyl Cyazofamide 101 Fungicide A Fungicide B Benomyl Amissulbrome 102 Fungicide A Fungicide B Benomyl Tricyclazol 103 Fungicide A Fungicide B Benomyl Oxatiapiproline 104 Fungicide A Fungicide B Benomyl Picarbutrazox 105 Fungicide A Fungicide B Carbendazim Ciproconazol 106 Fungicide A Fungicide B Carbendazim Difenoconazol 107 Fungicide A Fungicide B Carbendazim Epoxiconazol 108 Fungicide A Fungicide B Carbendazim Hexaconazol 109 Fungicide A Fungicide B Carbendazim Tebuconazol 110 Fungicide A Fungicide B Carbendazim Tetraconazol 111 Fungicide A Fungicide B Carbendazim Protioconazol 112 Fungicide A Fungicide B Carbendazim Azoxystrobin 113 Fungicide A Fungicide B Carbendazim Picoxistrobin 114 Fungicide A Fungicide B Carbendazim Pyraclostrobin 115 Fungicide A Fungicide B Carbendazim Cresoxim-methyla 116 Fungicide A Fungicide B Carbendazim Benomila 117 Fungicide A Fungicide B Carbendazim Metalaxil / MetalaxilM118 Fungicide A Fungicide B Carbendazim Thiophanate-methyl 119 Fungicide A Fungicide B Carbendazim Zoxamide 120 Fungicide A Fungicide B Carbendazim Fluopicolide 121 Fungicide A Fungicide B Carbendazim Fenamacril 122 Fungicide A Fungicide B Carbendazim Ciazofamide 123 Fungicide A Fungicide B Carbendazim Amisulbrom 124 Fungicide A Fungicide B Carbendazim Tricyclazole 125 Fungicide A Fungicide B Carbendazim Oxathiapiproline 126 Fungicide A Fungicide B Carbendazim Picarbutrazox 127 Fungicide A Fungicide B Thiophanate-methyl Cyproconazole 128 Fungicide A Fungicide B Thiophanate-methyl Difenoconazole 129 Fungicide A Fungicide B Thiophanate-methyl Epoxiconazole Petition 870260041192, dated 04 / 05 / 2026, pages 127 / 172 38 / 77 130 Fungicide A Fungicide B Thiophanate-methyl Hexaconazole 131 Fungicide A Fungicide B Thiophanate-methyl Tebuconazole 132 Fungicide A Fungicide B Thiophanate-methyl Tetraconazole 133 Fungicide A Fungicide B Thiophanate-methyl Prothioconazole 134 Fungicide A Fungicide B Thiophanate-methyl Azoxystrobin 135 Fungicide A Fungicide B Thiophanate-methyl Picoxystrobin 136 Fungicide A Fungicide B Thiophanate-methyl Pyraclostrobin 137 Fungicide A Fungicide B Thiophanate-methyl Cresoxim-methyl 138 Fungicide A Fungicide B Thiophanate-methyl Benomyl 139 Fungicide A Fungicide B Thiophanate-methyl Carbendazim 140 Fungicide A Fungicide B Thiophanate-methyl Metalaxyl / MetalaxylM 141 Fungicide A Fungicide B Thiophanate Methyl Zoxamide 142 Fungicide A Fungicide B Thiophanate Methyl Fluopicolide 143 Fungicide A Fungicide B Thiophanate Methyl Fenamacril 144 Fungicide A Fungicide B Thiophanate Methyl Ciazofamide 145 Fungicide A Fungicide B Thiophanate Methyl Amisulbrom 146 Fungicide A Fungicide B Thiophanate Methyl Tricyclazole 147Fungicide A Fungicide B Thiophanate-methyl Oxathiapiproline 148 Fungicide A Fungicide B Thiophanate-methyl Picarbutrazox 149 Fungicide A Fungicide B Zoxamide Cyproconazole 150 Fungicide A Fungicide B Zoxamide Difenoconazole 151 Fungicide A Fungicide B Zoxamide Epoxiconazole 152 Fungicide A Fungicide B Zoxamide Hexaconazole 153 Fungicide A Fungicide B Zoxamide Tebuconazole 154 Fungicide A Fungicide B Zoxamide Tetraconazole 155 Fungicide A Fungicide B Zoxamide Prothioconazole 156 Fungicide A Fungicide B Zoxamide Azoxystrobin 157 Fungicide A Fungicide B Zoxamide Picoxystrobin 158 Fungicide A Fungicide B Zoxamide Pyraclostrobin 159 Fungicide A Fungicide B Zoxamide Cresoxim-methyl 160 Fungicide A Fungicide B Zoxamide Benomyl Petition 870260041192, dated 04 / 05 / 2026, pages 128 / 172 39 / 77 161 Fungicide A Fungicide B Zoxamide Carbendazim 162 Fungicide A Fungicide B Zoxamide Metalaxyl / MetalaxylM 163 Fungicide A Fungicide B Zoxamide Thiophanate-methyl 164 Fungicide A Fungicide B Zoxamide Fluopicolide 165 Fungicide A Fungicide B Zoxamide Fenamacril 166 Fungicide A Fungicide B Zoxamide Cyazofamide 167 Fungicide A Fungicide B Zoxamide Amisulbrom 168 Fungicide A Fungicide B Zoxamide Tricyclazole 169 Fungicide A Fungicide B Zoxamide Oxathiapiproline 170 Fungicide A Fungicide B Zoxamide Picarbutrazox 171 Fungicide A Fungicide B Fluopicolide Cyproconazole 172 Fungicide A Fungicide B Fluopicolide Difenoconazole 173 Fungicide A Fungicide B Fluopicolide Epoxiconazole 174 Fungicide A Fungicide B Fluopicolide Hexaconazole 175 Fungicide A Fungicide B Fluopicolide Tebuconazole 176 Fungicide A Fungicide B Fluopicolide Tetraconazole 177 Fungicide A Fungicide B Fluopicolide Prothioconazole 178 Fungicide A Fungicide B Fluopicolide Azoxystrobin 179 Fungicide A Fungicide B Fluopicolide Picoxystrobin180 Fungicide A Fungicide B Fluopicolide Pyraclostrobin 181 Fungicide A Fungicide B Fluopicolide Cresoxim-methyl 182 Fungicide A Fungicide B Fluopicolide Benomyl 183 Fungicide A Fungicide B Fluopicolide Carbendazim 184 Fungicide A Fungicide B Fluopicolide Metalaxyl / MetalaxylM 185 Fungicide A Fungicide B Fluopicolide Thiophanate-methyl 186 Fungicide A Fungicide B Fluopicolide Zoxamide 187 Fungicide A Fungicide B Fluopicolide Fenamacril 188 Fungicide A Fungicide B Fluopicolide Cyazofamide 189 Fungicide A Fungicide B Fluopicolide Amisulbrom 190 Fungicide A Fungicide B Fluopicolide Tricyclazole Petition 870260041192, dated 04 / 05 / 2026, pages 129 / 172 40 / 77 191 Fungicide A Fungicide B Fluopicolide Oxathiapiproline 192 Fungicide A Fungicide B Fluopicolide Picarbutrazox 193 Fungicide A Fungicide B Fenamacril Ciproconazole 194 Fungicide A Fungicide B Fenamacril Difenoconazole 195 Fungicide A Fungicide B Fenamacril Epoxiconazole 196 Fungicide A Fungicide B Fenamacril Hexaconazole 197 Fungicide A Fungicide B Fenamacril Tebuconazole 198 Fungicide A Fungicide B Fenamacril Tetraconazole 199 Fungicide A Fungicide B Fenamacril Prothioconazole 200 Fungicide A Fungicide B Fenamacril Azoxystrobin 201 Fungicide A Fungicide B Fenamacril Picoxystrobin 202 Fungicide A Fungicide B Fenamacril Pyraclostrobin 203 Fungicide A Fungicide B Fenamacril Cresoxim-methyl 204 Fungicide A Fungicide B Fenamacril Benomyl 205 Fungicide A Fungicide B Fenamacril Carbendazim 206 Fungicide A Fungicide B Fenamacril Metalaxyl / MetalaxylM 207 Fungicide A Fungicide B Fenamacril Thiophanate-methyl 208 Fungicide A Fungicide B Fenamacril Zoxamide 209 Fungicide A Fungicide B FenamacrilFluopicolida 210 Fungicide A Fungicide B Fenamacril Cyazofamide 211 Fungicide A Fungicide B Fenamacril Amissulbrome 212 Fungicide A Fungicide B Fenamacril Triciclazol 213 Fungicide A Fungicide B Fenamacril Oxatiapiproline 214 Fungicide A Fungicide B Fenamacril Picarbutrazox 215 Fungicide A Fungicide B Cyazofamide Cyproconazol 216 Fungicide A Fungicide B Cyazofamide Difenoconazol 217 Fungicide A Fungicide B Cyazofamide Epoxiconazol 218 Fungicide A Fungicide B Cyazofamide Hexaconazol 219 Fungicide A Fungicide B Cyazofamide Tebuconazol 220 Fungicide A Fungicide B Cyazofamide Tetraconazol 221 Fungicide A Fungicide B Cyazofamide Prothioconazole Petition 870260041192, dated 04 / 05 / 2026, pág. 130 / 172 41 / 77 222 Fungicide A Fungicide B Cyazophamide Azoxystrobin 223 Fungicide A Fungicide B Cyazophamide Picoxystrobin 224 Fungicide A Fungicide B Cyazophamide Pyraclostrobin 225 Fungicide A Fungicide B Cyazophamide Cresoxim-methyla 226 Fungicide A Fungicide B Cyazophamide Benomyl 227 Fungicide A Fungicide B Cyazophamide Carbendazim 228 Fungicide A Fungicide B Cyazophamide Metalaxyl / MetalaxilM 229 Fungicide A Fungicide B Cyazophamide Thiophanate methyl 230 Fungicide A Fungicide B Cyazophamide Zoxamida 231 Fungicide A Fungicide B Cyazophamide Fluopicolida 232 Fungicide A Fungicide B Cyazofamide Fenamacril 233 Fungicide A Fungicide B Cyazophamide Amissulbrome 234 Fungicide A Fungicide B Cyazophamide Triciclazol 235 Fungicide A Fungicide B Cyazophamide Oxatiapiproline 236 Fungicide A Fungicide B Cyazophamide Picarbutrazox 237 Fungicide A Fungicide B Amissulbrome Cyproconazol 238 Fungicide A Fungicide B Amissulbrome Difenoconazol 239 Fungicide A Fungicide B Amissulbrome Epoxiconazol 240 Fungicide A Fungicide BAmissulbrome Hexaconazole 241 Fungicide A Fungicide B Amissulbrome Tebuconazole 242 Fungicide A Fungicide B Amissulbrome Tetraconazole 243 Fungicide A Fungicide B Amissulbrome Prothioconazole 244 Fungicide A Fungicide B Amissulbrome Azoxystrobin 245 Fungicide A Fungicide B Amissulbrome Picoxystrobin 246 Fungicide A Fungicide B Amissulbrome Pyraclostrobin 247 Fungicide A Fungicide B Amissulbrome Kresoxim-methyl 248 Fungicide A Fungicide B Amissulbrome Benomyl 249 Fungicide A Fungicide B Amissulbrome Metalaxil / MetalaxilM 250 Fungicide A Fungicide B Amissulbrome Carbendazim 251 Fungicide A Fungicide B Amissulbrome Thiophanate methyl Petition 870260041192, dated 04 / 05 / 2026, p. 131 / 172 42 / 77 252 Fungicide A Fungicide B Amissulbrome Zoxamida 253 Fungicide A Fungicide B Amissulbrome Fluopicolida 254 Fungicide A Fungicide B Amissulbrome Cyazofamide 255 Fungicide A Fungicide B Amissulbrome Triciclazol 256 Fungicide A Fungicide B Amissulbrome Oxatiapiproline 257 Fungicide A Fungicide B Amissulbrome Picarbutrazox 258 Fungicide A Fungicide B Triciclazol Ciproconazol 259 Fungicide A Fungicide B Tricyclazol Difenoconazol 260 Fungicide A Fungicide B Triciclazol Epoxiconazol 261 Fungicide A Fungicide B Tricyclazol Hexaconazol 262 Fungicide A Fungicide B Tricyclazol Tebuconazol 263 Fungicide A Fungicide B Tricyclazol Tetraconazol 264 Fungicide A Fungicide B Tricyclazol Protioconazol 265 Fungicide A Fungicide B Tricyclazol Azoxystrobin 266 Fungicide A Fungicide B Tricyclazol Picoxystrobin 267 Fungicide A Fungicide B Tricyclazol Pyraclostrobin 268 Fungicide A Fungicide B Tricyclazol Cresoxim-methyla 269 Fungicide A Fungicide B Tricyclazol Benomyla 270 Fungicide A Fungicide BTricyclazole Carbendazim 271 Fungicide A Fungicide B Tricyclazole Metalaxyl / MetalaxylM 272 Fungicide A Fungicide B Tricyclazole Thiophanate methyl 273 Fungicide A Fungicide B Tricyclazole Zoxamide 274 Fungicide A Fungicide B Tricyclazole Fluopicolide 275 Fungicide A Fungicide B Tricyclazole Ciazofamide 276 Fungicide A Fungicide B Tricyclazole Amisulbrome 277 Fungicide A Fungicide B Tricyclazole Oxathiapiprolina 278 Fungicide A Fungicide B Tricyclazole Picarbutrazox 279 Fungicide A Fungicide B Picarbutrazox Cyproconazole 280 Fungicide A Fungicide B Picarbutrazox Difenoconazole 281 Fungicide A Fungicide B Picarbutrazox Epoxiconazole 282 Fungicide A Fungicide B Picarbutrazox Hexaconazole Petition 870260041192, dated 04 / 05 / 2026, pages 132 / 172 43 / 77 283 Fungicide A Fungicide B Picarbutrazox Tebuconazol 284 Fungicide A Fungicide B Picarbutrazox Tetraconazol 285 Fungicide A Fungicide B Picarbutrazox Prothioconazol 286 Fungicide A Fungicide B Picarbutrazox Azoxystrobin 287 Fungicide A Fungicide B Picarbutrazox Picoxystrobin 288 Fungicide A Fungicide B Picarbutrazox Pyraclostrobin 289 Fungicide A Fungicide B Picarbutrazox Cresoxim-methyl 290 Fungicide A Fungicide B Picarbutrazox Benomyla 291 Fungicide A Fungicide B Picarbutrazox Carbendazim 292 Fungicide A Fungicide B Picarbutrazox Metalaxil / MetalaxilM 293 Fungicide A Fungicide B Picarbutrazox Thiophanate methyl 294 Fungicide A Fungicide B Picarbutrazox Zoxamida 295 Fungicide A Fungicide B Picarbutrazox Fluopicolida 296 Fungicide A Fungicide B Picarbutrazox Cyazofamide 297 Fungicide A Fungicide B Picarbutrazox Amissulbrome 298 Fungicide A Fungicide B Picarbutrazox Oxatiapiproline 299 Fungicide A Fungicide B Oxatiapiproline Ciproconazol 300 Fungicide A Fungicide B OxatiapiprolineDifenoconazole 301 Fungicide A Fungicide B Oxathiapiproline Epoxiconazole 302 Fungicide A Fungicide B Oxathiapiproline Hexaconazole 303 Fungicide A Fungicide B Oxathiapiproline Tebuconazole 304 Fungicide A Fungicide B Oxathiapiproline Tetraconazole 305 Fungicide A Fungicide B Oxathiapiproline Prothioconazole 306 Fungicide A Fungicide B Oxathiapiproline Azoxystrobin 307 Fungicide A Fungicide B Oxathiapiproline Picoxystrobin 308 Fungicide A Fungicide B Oxathiapiproline Pyraclostrobin 309 Fungicide A Fungicide B Oxathiapiproline Cresoxim-methyl 310 Fungicide A Fungicide B Oxathiapiproline Benomyl 311 Fungicide A Fungicide B Oxathiapiproline Carbendazim 312 Fungicide A Fungicide B Oxathiapiprolina Metalaxil / MetalaxilM Petition 870260041192, dated 04 / 05 / 2026, pages 133 / 172 44ΠΊ 313 Fungicide A Fungicide B Oxathiapiproline Thiophanate-methyl 314 Fungicide A Fungicide B Oxathiapiproline Zoxamide 315 Fungicide A Fungicide B Oxathiapiproline Fluopicolide 316 Fungicide A Fungicide B Oxathiapiproline Cyazofamide 317 Fungicide A Fungicide B Oxathiapiproline Amisulbrom 318 Fungicide A Fungicide B Oxathiapiproline Picarbutrazox

[0160] In all embodiments 1 to 318 described herein in the table above, fungicide A may be present or may be entirely absent from the combinations. However, the presence of fungicide B is essential according to the present invention.

[0161] In one embodiment of the combinations of the present invention, the preferred multisite fungicide is captan.

[0162] In one embodiment, the combinations of the present invention include the following preferred combinations: S No. I II III IV 319 Mancozebe Captan Cyproconazole - 320 Mancozebe Captan Difenoconazole - 321 Mancozebe Captan Epoxiconazole - 322 Mancozebe Captan Hexaconazole - 323 Mancozebe Captan Tebuconazole - 324 Mancozebe Captan Tetraconazole - 325 Mancozebe Captan Prothioconazole - 326 Mancozebe Captan - Azoxystrobin 327 Mancozebe Captan - Picoxystrobin 328 Mancozebe Captan - Pyraclostrobin 329 Mancozebe Captan - Cresoxim-methyl 330 Mancozebe Captan - Trifloxystrobin 331 Mancozebe Captan Cyproconazole Azoxystrobin Petition 870260041192, dated 05 / 04 / 2026, page. 134 / 172 45 / 77 332 Mancozebe Captano Ciproconazol Picoxistrobina 333 Mancozebe Captano Ciproconazol Piraclostrobina 334 Mancozebe Captano Ciproconazol Cresoxim-metila 335 Mancozebe Captano Ciproconazol Trifloxistrobina 336 Mancozebe Captano Difenoconazol Azoxistrobina 337 Mancozebe Captano Difenoconazol Picoxistrobina 338 Mancozebe Captano Difenoconazol Piraclostrobina 339 Mancozebe Captano Difenoconazol Cresoxim-metila 340 Mancozebe Captano Difenoconazol Trifloxistrobina 341 Mancozebe Captano Epoxiconazol Azoxistrobina 342 Mancozebe Captano Epoxiconazol Picoxistrobina 343 Mancozebe Captano Epoxiconazol Piraclostrobina 344 Mancozebe Captano Epoxiconazol Cresoxim-metila 345 Mancozebe Captano Epoxiconazol Trifloxistrobina 346 Mancozebe Captano Hexaconazol Azoxistrobina 347 Mancozebe Captano Hexaconazol Picoxistrobina 348 Mancozebe Captano Hexaconazol Piraclostrobina 349 Mancozebe Captano Hexaconazol Cresoxim-metila 350 Mancozebe Captano Hexaconazol Trifloxistrobina 351 Mancozebe Captano TebuconazolAzoxystrobin 352 Mancozeb Captan Tebuconazole Picoxystrobin 353 Mancozeb Captan Tebuconazole Pyraclostrobin 354 Mancozeb Captan Tebuconazole Cresoxim-methyl 355 Mancozeb Captan Tebuconazole Trifloxystrobin 356 Mancozeb Captan Tetraconazole Azoxystrobin 357 Mancozeb Captan Tetraconazole Picoxystrobin 358 Mancozeb Captan Tetraconazole Pyraclostrobin 359 Mancozeb Captan Tetraconazole Cresoxim-methyl 360 Mancozeb Captan Tetraconazole Trifloxystrobin 361 Mancozeb Captan Prothioconazole Azoxystrobin 362 Mancozeb Captan Prothioconazole Picoxystrobin 363 Mancozeb Captan Prothioconazole Pyraclostrobin Petição 870260041192, de 04 / 05 / 2026, pág. 135 / 172 46 / 77 364 Mancozebe Captano Protioconazol Cresoxim-metila 365 Mancozebe Captano Protioconazol Trifloxistrobina

[0163] In all embodiments 319 to 365 described herein in the table above, mancozeb may be present or may be entirely absent from the combinations. However, the presence of captan is essential according to the present invention.

[0164] In one embodiment of the combinations of the present invention, the preferred multisite fungicide is captafol.

[0165] In one embodiment, the combinations of the present invention include the following preferred combinations: S No. I II III IV 366 Mancozebe Captafol Ciproconazol - 367 Mancozebe Captafol Difenoconazol - 368 Mancozebe Captafol Epoxiconazol - 369 Mancozebe Captafol Hexaconazol - 370 Mancozebe Captafol Tebuconazol - 371 Mancozebe Captafol Tetraconazol - 372 Mancozebe Captafol Protioconazol - 373 Mancozebe Captafol - Azoxistrobina 374 Mancozebe Captafol - Picoxistrobina 375 Mancozebe Captafol - Piraclostrobina 376 Mancozebe Captafol - Cresoxim-metila 377 Mancozebe Captafol - Trifloxistrobina 378 Mancozebe Captafol Ciproconazol Azoxistrobina 379 Mancozebe Captafol Ciproconazol Picoxistrobina 380 Mancozebe Captafol Ciproconazol Piraclostrobina 381 Mancozebe Captafol Ciproconazol Cresoxim-metila 382 Mancozebe Captafol Ciproconazol Trifloxistrobina Petição 870260041192, de 04 / 05 / 2026, pág. 136 / 172 47 / 77 383 Mancozebe Captafol Difenoconazol Azoxistrobina 384 Mancozebe Captafol Difenoconazol Picoxistrobina 385 Mancozebe Captafol Difenoconazol Piraclostrobina 386 Mancozebe Captafol Difenoconazol Cresoxim-metila 387 Mancozebe Captafol Difenoconazol Trifloxistrobina 388 Mancozebe Captafol Epoxiconazol Azoxistrobina 389 Mancozebe Captafol Epoxiconazol Picoxistrobina 390 Mancozebe Captafol Epoxiconazol Piraclostrobina 391 Mancozebe Captafol Epoxiconazol Cresoxim-metila 392 Mancozebe Captafol Epoxiconazol Trifloxistrobina 393 Mancozebe Captafol Hexaconazol Azoxistrobina 394 Mancozebe Captafol Hexaconazol Picoxistrobina 395 Mancozebe Captafol Hexaconazol Piraclostrobina 396 Mancozebe Captafol Hexaconazol Cresoxim-metila 397 Mancozebe Captafol Hexaconazol Trifloxistrobina 398 Mancozebe Captafol Tebuconazol Azoxistrobina 399 Mancozebe Captafol Tebuconazol Picoxistrobina 400 Mancozebe Captafol Tebuconazol Piraclostrobina 401 Mancozebe Captafol Tebuconazol Cresoxim-metila 402 Mancozebe CaptafolTebuconazole Trifloxystrobin 403 Mancozeb Captafol Tetraconazole Azoxystrobin 404 Mancozeb Captafol Tetraconazole Picoxystrobin 405 Mancozeb Captafol Tetraconazole Pyraclostrobin 406 Mancozeb Captafol Tetraconazole Cresoxim-methyl 407 Mancozeb Captafol Tetraconazole Trifloxystrobin 408 Mancozeb Captafol Prothioconazole Azoxystrobin 409 Mancozeb Captafol Prothioconazole Picoxystrobin 410 Mancozeb Captafol Prothioconazole Pyraclostrobin 411 Mancozeb Captafol Prothioconazole Cresoxim-methyl 412 Mancozeb Captafol Prothioconazole Trifloxystrobin Petition 870260041192, dated 04 / 05 / 2026, pages 137 / 172 48 / 77

[0166] In all embodiments 366 to 412 described herein in the table above, mancozeb may be present or may be entirely absent from the combinations. However, the presence of captafol is essential according to the present invention.

[0167] In one embodiment of the combinations to be used in the methods of the present invention, the preferred multisite fungicide is folpet.

[0168] In one embodiment, the combinations of the present invention include the following preferred combinations: S No. I II III IV 413 Mancozebe Folpete Ciproconazol - 414 Mancozebe Folpete Difenoconazol - 415 Mancozebe Folpete Epoxiconazol - 416 Mancozebe Folpete Hexaconazol - 417 Mancozebe Folpete Tebuconazol - 418 Mancozebe Folpete Tetraconazol - 419 Mancozebe Folpete Protioconazol - 420 Mancozebe Folpete - Azoxistrobina 421 Mancozebe Folpete - Picoxistrobina 422 Mancozebe Folpete - Piraclostrobina 423 Mancozebe Folpete - Cresoxim-metila 424 Mancozebe Folpete - Trifloxistrobina 425 Mancozebe Folpete Ciproconazol Azoxistrobina 426 Mancozebe Folpete Ciproconazol Picoxistrobina 427 Mancozebe Folpete Ciproconazol Piraclostrobina 428 Mancozebe Folpete Ciproconazol Cresoxim-metila 429 Mancozebe Folpete Ciproconazol Trifloxistrobina 430 Mancozebe Folpete Difenoconazol Azoxistrobina 431 Mancozebe Folpete Difenoconazol Picoxistrobina 432 Mancozebe Folpete Difenoconazol Piraclostrobina Petição 870260041192, de 04 / 05 / 2026, pág. 138 / 172 49 / 77 433 Mancozebe Folpete Difenoconazol Cresoxim-metila 434 Mancozebe Folpete Difenoconazol Trifloxistrobina 435 Mancozebe Folpete Epoxiconazol Azoxistrobina 436 Mancozebe Folpete Epoxiconazol Picoxistrobina 437 Mancozebe Folpete Epoxiconazol Piraclostrobina 438 Mancozebe Folpete Epoxiconazol Cresoxim-metila 439 Mancozebe Folpete Epoxiconazol Trifloxistrobina 440 Mancozebe Folpete Hexaconazol Azoxistrobina 441 Mancozebe Folpete Hexaconazol Picoxistrobina 442 Mancozebe Folpete Hexaconazol Piraclostrobina 443 Mancozebe Folpete Hexaconazol Cresoxim-metila 444 Mancozebe Folpete Hexaconazol Trifloxistrobina 445 Mancozebe Folpete Tebuconazol Azoxistrobina 446 Mancozebe Folpete Tebuconazol Picoxistrobina 447 Mancozebe Folpete Tebuconazol Piraclostrobina 448 Mancozebe Folpete Tebuconazol Cresoxim-metila 449 Mancozebe Folpete Tebuconazol Trifloxistrobina 450 Mancozebe Folpete Tetraconazol Azoxistrobina 451 Mancozebe Folpete Tetraconazol Picoxistrobina 451 Mancozebe Folpete TetraconazolPyraclostrobin 452 Mancozeb Folpet Tetraconazole Cresoxim-methyl 453 Mancozeb Folpet Tetraconazole Trifloxystrobin 454 Mancozeb Folpet Prothioconazole Azoxystrobin 455 Mancozeb Folpet Prothioconazole Picoxystrobin 456 Mancozeb Folpet Prothioconazole Pyraclostrobin 457 Mancozeb Folpet Prothioconazole Cresoxim-methyl 458 Mancozeb Folpet Prothioconazole Trifloxystrobin

[0169] In all modalities 413 to 458 described here in the table above, mancozeb may be present or may be completely absent. Petition 870260041192, dated 04 / 05 / 2026, pages 139 / 172 50 / 77 of the combinations. However, the presence of folpet is essential according to the present invention.

[0170] In one embodiment, the combinations for use in the treatment of zymoseptoria infection in cereal plants comprise: (a) at least one phthalimide fungicide and; (b) agrochemically acceptable excipient.

[0171] In one embodiment, the combinations for use in the treatment of zymoseptoria infection in cereal plants comprise: (a) at least one phthalimide fungicide selected from folpet, captfol or captan; and; (b) agrochemically acceptable excipient.

[0172] In one embodiment, the combinations for use in the methods of the present invention comprise: (a) at least one phthalimide fungicide; (b) optionally, at least one dithiocarbamate fungicide; (c) at least one external quinone inhibitor; and (d) at least one agrochemically acceptable excipient.

[0173] In one embodiment, the combinations for use in the methods of the present invention comprise: (a) at least one phthalimide fungicide; (b) optionally, at least one dithiocarbamate fungicide; (c) at least one ergostrol biosynthesis inhibitor; and (d) at least one agrochemically acceptable excipient.

[0174] In one embodiment, the combinations for use in the methods of the present invention comprise: (a) at least one phthalimide fungicide; (b) optionally, at least one dithiocarbamate fungicide; Petition 870260041192, dated 04 / 05 / 2026, pages 140 / 172 51 / 77 (c) at least one external quinone inhibitor; (d) at least one ergostrol biosynthesis inhibitor; and (e) at least one agrochemically acceptable excipient.

[0175] The amount of a composition according to the invention to be applied will depend on several factors, such as the part involved in the treatment, such as plants, soil or seeds; the type of treatment, such as spraying, splashing or seed covering; the purpose of the treatment, such as prophylactic or therapeutic disease control; and in the case of disease control, the type of fungus to be controlled or the application time. This amount of the combinations of the present invention to be applied can be readily deduced by a qualified agronomist.

[0176] Thus, in one embodiment, the present invention may provide combinations for use in the methods of the present invention comprising: (a) at least one phthalimide fungicide selected from folpet, captfol or captan; (b) at least one external quinone inhibitor, and / or at least one ergostrol biosynthesis inhibitor; and (c) optionally, at least one dithiocarbamate fungicide.

[0177] In one embodiment, the constituents of the composition for use in the methods of the present invention may be mixed in the tank and sprayed onto the site of infection, or they may alternatively be mixed with surfactants and then sprayed.

[0178] In one embodiment, the constituents of the composition for use in the methods of the present invention can be used for foliar application, in the soil or applications in plant propagation materials. Petition 870260041192, dated 04 / 05 / 2026, pages 141 / 172 52 / 77

[0179] In one embodiment, the compositions for use in the methods of the present invention can typically be produced by mixing the active ingredients in the composition with an inert carrier, and adding surfactants and other adjuvants and carriers as needed, and formulated in solid or liquid formulations, including, but not limited to, wettable powders, water-dispersible granules (WDGs), dusts, soluble concentrates (liquids), suspension concentrates (SCs), oil-in-water emulsions, water-in-oil emulsions, emulsifiable concentrates, capsule suspensions, ZC formulations, oil dispersions, or other known types of formulation. The composition can also be used for the treatment of plant propagation material, such as seeds, etc.

[0180] Depending on the type of formulation, these comprise one or more liquid or solid carriers, if appropriate, surfactants (such as dispersants, protective colloids, emulsifiers, wetting agents and tack enhancers), and, if appropriate, additional auxiliaries that are customary for the formulation of crop protection products. Those skilled in the art are sufficiently familiar with the recipes for such formulations. Additional auxiliaries include, for example, organic and inorganic thickeners, bactericides, antifreeze agents, antifoaming agents, colorants and, for seed formulations, adhesives.

[0181] Suitable vehicles include liquid and solid vehicles. Examples of solid carriers used in formulations include fine powders or granules, such as minerals like kaolin clay, attapulgite clay, bentonite, montmorillonite, acid white clay, pyrophyllite, talc, diatomaceous earth, and calcite; natural organic materials, such as shaft powder... Petition 870260041192, dated 04 / 05 / 2026, pages 142 / 172 53 / 77 corn and walnut shell powder; synthetic organic materials, such as urea; salts, such as calcium carbonate and ammonium sulfate; synthetic inorganic materials, such as synthetic hydrated silicon oxide and the like. The liquid carrier includes aromatic hydrocarbons, such as xylene, alkylbenzene and methylnaphthalene; alcohols such as 2-propanol, ethylene glycol, propylene glycol and ethylene glycol monoethyl ether; ketones, such as acetone, cyclohexanone and isophorone; vegetable oil, such as soybean oil and cottonseed oil; aliphatic petroleum hydrocarbons, esters, dimethyl sulfoxide, acetonitrile and water and the like.

[0182] Examples of surfactants include anionic surfactants such as alkyl sulfate ester salts, alkylaryl sulfonate salts, dialkyl sulfosuccinate salts, polyoxyethylene alkylaryl ether phosphate ester salts, lignosulfonate salts and polycondensates of naphthalene sulfonate formaldehyde; and nonionic surfactants such as polyoxyethylene alkylaryl ethers, polyoxyethylene and alkylpolyoxypropylene block copolymers and sorbitan fatty acid esters and cationic surfactants such as alkyltrimethylammonium salts.

[0183] Examples of other formulation aids include water-soluble polymers such as polyvinyl alcohol and polyvinylpyrrolidone, polysaccharides such as gum arabic, alginic acid and its salt, CMC (carboxymethylcellulose), xanthan gum, inorganic materials such as aluminum magnesium silicate and alumina sol, preservatives, coloring agents and stabilizing agents such as BHT.

[0184] The combinations of the present invention, for use in the methods of the present invention, may be sold as a premix composition or a parts kit, so that the individual active ingredients can be mixed before spraying. Alternatively, the parts kit may Petition 870260041192, dated 04 / 05 / 2026, pp. 143 / 172 54 / 77 contains the phthalimide fungicide and the second and / or third fungicide premixed with an adjuvant, so that the two components can be tank mixed before spraying.

[0185] In another embodiment, a phthalimide fungicide and a second and / or a third fungicide may be premixed with an adjuvant and added to a combined package, so that the fungicides may be tank-mixed before spraying.

[0186] One aspect of the present invention may provide a kit comprising: a phthalimide component comprising at least one phthalimide fungicide selected from captan, captafol or folpet; and a second fungicidal component comprising at least one systemic fungicide or a combination of systemic fungicides.

[0187] One aspect of the present invention may provide a kit comprising: a first fungicidal component comprising at least one multi-site fungicide; a phthalimide component comprising at least one phthalimide fungicide selected from captan, captafol or folpet; and a second fungicidal component comprising at least one systemic fungicide or a combination of systemic fungicides.

[0188] Another aspect of the present invention may provide a kit comprising: a first fungicidal component comprising at least one dithiocarbamate fungicide; a phthalimide component comprising at least one phthalimide fungicide selected from captan, captafol or folpet; and Petition 870260041192, dated 04 / 05 / 2026, pages 144 / 172 55 / 77 a second fungicidal component comprising at least one systemic fungicide or a combination of systemic fungicides.

[0189] Yet another aspect of the present invention may provide a kit comprising: a fungicidal component comprising at least one multi-site fungicide, preferably a dithiocarbamate fungicide; a phthalimide component comprising at least one phthalimide fungicide selected from captan, captafol or folpet; and a fungicidal component comprising at least one first systemic fungicide; and a fungicidal component comprising at least one second systemic fungicide.

[0190] The composition of the present invention, for use in the methods of the present invention, can be applied simultaneously as a tank mix, or a formulation can be applied sequentially. Application can be made to the soil before plant emergence, both before planting and after planting. Application can be made as a foliar spray at different times during crop development, with one or two early or late applications after emergence.

[0191] The compositions according to the invention, for use in the methods of the present invention, can be applied before or after infection of useful plants or their propagation material by fungi.

[0192] Preferably, as demonstrated, the use of a phthalimide fungicide has been found to be surprisingly effective for the control of Septoria. In one embodiment, the phthalimide fungicide can be combined with another fungicide selected from at least one Petition 870260041192, dated 04 / 05 / 2026, pages 145 / 172 56 / 77 dithiocarbamate fungicides, which are optionally combined with external quinone inhibitors and / or ergosterol biosynthesis inhibitors and / or a succinate dehydrogenase inhibitor fungicide, have greatly improved disease control, as well as improved yield and demonstrated a synergistic effect.

[0193] As demonstrated, mixing multisite phthalimide fungicides with at least one other fungicide greatly improved disease and insect pest control, as well as improved yield.

[0194] It has been surprisingly found that the present compositions comprising a multi-site phthalimide fungicide and in combination with one or more other systemic fungicides have intensified control of fungal leaf spot diseases caused by Zymoseptoria infections in host plants, for example, in cereals such as wheat. These compositions have also been found to improve plant quality by reducing stress and improving nutrient levels, thus increasing plant yield that has been infected with a fungicidal infection, especially with Zymoseptoria tritici infection.

[0195] The examples and Tables 1 to 7 shown here demonstrate the effectiveness of captan and combinations thereof with other fungicides in controlling fungal diseases caused by zymoseptoria infections in cereals, particularly wheat plants.

[0196] Fungal leaf spot diseases include, but are not limited to, brown spot, Septoria / Stagonospora nodorum blotch (SNB), and Septoria tritici blotch (STB).

[0197] In one aspect, the present invention provides a fungicidal composition comprising an effective fungicidal amount of a Petition 870260041192, dated 04 / 05 / 2026, pages 146 / 172 57 / 77 is a multi-site fungicide comprising, preferably, captan to control Zymoseptoria tritici in a leguminous host plant.

[0198] In one aspect, the present invention provides a fungicidal composition comprising an effective amount as a fungicide of a multi-site fungicide, preferably comprising captan, to control Zymoseptoria tritici in cereal plants.

[0199] In another aspect, the present invention provides a fungicidal composition comprising an effective amount as a fungicide of a multi-site contact fungicide for controlling Septoria tritici leaf spot (STB) in a host legume plant.

[0200] In another aspect, the present invention provides a fungicidal composition comprising an effective amount as a fungicide of a multi-site contact fungicide to control Septoria tritici leaf spot (STB) caused by Zymoseptoria tritici in a host legume plant.

[0201] In another aspect, the multi-site contact fungicide is a phthalimide fungicide.

[0202] In one embodiment, the multi-site contact fungicide is selected from folpet, captan, captafol, or combinations thereof.

[0203] In one embodiment, the multi-site contact fungicide is captan.

[0204] In one embodiment, the multisite contact fungicide is a combination comprising at least one of captan, folpet, or captafol; and at least one other multisite contact fungicide, as described herein. In this embodiment, the second multisite fungicide is a contact fungicide other than captan, folpet, or captafol. Petition 870260041192, dated 04 / 05 / 2026, pages 147 / 172 58 / 77

[0205] In another aspect, the present invention provides a fungicidal composition comprising a phthalimide fungicide, in particular Captan, and at least one agrochemically acceptable excipient for treating the zymoseptoria fungus in a host legume plant.

[0206] In another aspect, the present invention provides a fungicidal composition comprising a phthalimide fungicide, in particular, Captan, for treating fungal leaf spot disease caused by the fungus Zymoseptoria in a host legume plant.

[0207] In another aspect, the present invention provides a fungicidal composition comprising an effective amount of captan as a fungicide for controlling Septoria tritici leaf spot (STB) caused by Zymoseptoria tritici in cereal plants.

[0208] In another aspect, the present invention provides a fungicidal combination for treating zymoseptoria infection in a host legume plant, wherein the combination comprises: 1) Captane and 2) at least one other fungicide selected from among an external quinone inhibitor, succinate dehydrogenase inhibitor, internal quinone inhibitor, or combinations thereof.

[0209] In another aspect, the present invention provides a fungicidal composition for treating zymoseptoria infection in a host legume plant, wherein the composition comprises: 1) Captane and 2) at least one other fungicide selected from among an external quinone inhibitor, succinate dehydrogenase inhibitor, internal quinone inhibitor, or combinations thereof; and 3) at least one agrochemically acceptable excipient. Petition 870260041192, dated 04 / 05 / 2026, pages 148 / 172 59 / 77

[0210] In one embodiment, the effective amount of captan in the combination is in the range of 40 to 80%, by weight, of the composition, preferably 50 to 60%, by weight, of the composition.

[0211] In one embodiment, the effective amount of another fungicide selected from among an external quinone inhibitor, succinate dehydrogenase inhibitor, internal quinone inhibitor or combinations thereof, present in the combination is in the range of about 5% to 25% by weight of the composition, preferably 5% to 20% by weight of the composition, preferably 5% to 15% by weight of the composition, preferably 5% to 10% by weight of the composition.

[0212] In one embodiment, the composition comprises captan and prothioconazole.

[0213] In one embodiment, the composition comprises 10 to 70% by weight of captan and 5% to 25% by weight of prothioconazole.

[0214] Thus, in one embodiment, the present invention provides a method for treating Zymoseptoria tritici in a host legume plant, wherein the method comprises treating the plant at the site of infection with Captan; and simultaneously, before or subsequent to Captan, with prothioconazole.

[0215] In one embodiment, the composition comprises captan and fluxapyroxad.

[0216] In one embodiment, the composition comprises 10 to 70% by weight of captan and 5% to 25% by weight of fluxapyroxad.

[0217] In one embodiment, the composition comprises captan, prothioconazole and fluxapyroxad.

[0218] In one embodiment, the composition comprises captan and difenoconazole. Petition 870260041192, dated 04 / 05 / 2026, pages 149 / 172 60 / 77

[0219] In one embodiment, the composition comprises 10 to 70% by weight of captan and 5% to 25% by weight of difenoconazole.

[0220] Thus, in one embodiment, the present invention provides a method for controlling / treating Zymoseptoria tritici in a host legume plant, wherein the method comprises treating the plant at the site of infection with Captan; and concomitantly, before or subsequent to Captan, with Difenoconazole.

[0221] In one embodiment, the composition comprises captan and fluoxastrobin or azoxystrobin or a combination thereof.

[0222] In one embodiment, the composition comprises 10 to 70% by weight of captan and 5% to 25% by weight of fluoxastrobin or azoxystrobin.

[0223] In another aspect, the present invention provides the use of a multi-site fungicide to control zymoseptoria infection in a host plant.

[0224] In another aspect, the present invention provides the use of a multisite fungicide for the treatment of fungal leaf spot disease caused by zymoseptoria fungus in a host plant.

[0225] In another aspect, the present invention provides the use of a multisite fungicide for the treatment of fungal leaf spot disease caused by zymoseptoria fungus in wheat plants.

[0226] In another aspect, the present invention provides the use of a multi-site fungicide to control zymoseptoria infection in a host plant when applied subsequently, before or simultaneously with at least one other fungicide selected from an external quinone inhibitor, succinate dehydrogenase inhibitor, internal quinone inhibitor or combinations thereof. Petition 870260041192, dated 04 / 05 / 2026, pages 150 / 172 61 / 77

[0227] In one embodiment, the multisite contact fungicide is selected from folpet, captan or captafol.

[0228] In one embodiment, the multi-site contact fungicide is captan.

[0229] In one embodiment, the multisite contact fungicide is a combination comprising one of captan, folpet, or captafol; and at least one other multisite contact fungicide, as described herein. In this embodiment, the second multisite fungicide is a contact fungicide other than captan, folpet, or captafol.

[0230] In another aspect, the present invention provides a method for treating fungal leaf spot disease in a host plant, comprising treating the plant at the site of infection with Captan; and simultaneously, before or after Captan, with at least one other fungicide selected from a demethylation inhibitor, external quinone inhibitor, succinate dehydrogenase inhibitor, internal quinone inhibitor or combinations thereof.

[0231] It is readily understood that the treatment method of the present invention can be used on all host plants that are infected by zymoseptoria pathogen. Exemplary host plants may include cereal plants, their seeds, or the soil.

[0232] Consequently, the compositions described herein can control a broad spectrum of plant diseases in crops including: cereal grain crops such as wheat, barley, oats, rye, triticale, rice, maize, sorghum and millet; vine crops such as table and wine grapes; field crops such as oilseed rapeseed (canola), sunflower; sugar beet, sugarcane, soybean, peanut (groundnut), tobacco, alfalfa, clover, Petition 870260041192, dated 04 / 05 / 2026, pages 151 / 172 62 / 77 lespedeza, trifoliate and vetiver; ointment fruits, such as apple, pear, cranberry, loquat, maize and quince; stone fruits, such as peaches, cherries, plums, apricots, nectarines and almonds; citrus fruits, such as lemons, limes, oranges, grapefruit, mandarin (tangerines) and persimmon; root vegetables and tubers and field crops (and their leaves) such as artichoke, garden beet and sugar beet, carrot, cassava, ginger, ginseng, horseradish, parsnip, potato, radish, rutabaga, sweet potato, turnip and yam; bulb vegetables such as garlic, leek, onion and shallot; Leafy vegetables such as arugula (roquette), celery, cress, endive (escarole), fennel, head and leaf lettuce, parsley, radicchio (red chicory), rhubarb, spinach and Swiss garden lettuce; Brassia leafy vegetables such as broccoli, broccoli raab (rapini), Brussels sprouts, cabbage, Chinese cabbage, cauliflower, kale, collard greens, kohlrabi, mustard greens and vegetables;Vegetables (succulent or dried) such as lupins, beans (Phaseolus spp.) (including field beans, purple beans, lima beans, white beans, carioca beans, Spanish beans, green beans, tepary beans and wax beans), beans (Vigna spp.) (including adzuki beans, asparagus beans, black peas, cat beans, Chinese long beans, string beans, cowpeas, Asian beans, rice beans, southern peas, black beans and garden beans), broad beans (fava), chickpeas (garbanzo), guar beans, chickpeas, pencil beans, lentils and peas (Pisum spp.) (including dwarf peas, cowpeas, English peas, field peas, garden peas, green peas, snow peas, snap sugar peas, pigeon peas and soybeans); Fruity vegetables such as eggplant, ground cherry (Physalis spp.), cucumber and peppers (including bell peppers, chili peppers, cooked peppers, pimento, sweet peppers; tomatillo and tomato);Cucurbitaceous vegetables, such as Chayote (fruit), Chinese deer (Chinese pickling melon), citron melon, cucumber, gherkin, edible gourd (including hyothane,; Petition 870260041192, dated 04 / 05 / 2026, pages 152 / 172 63 / 77 cucuzza, hechima and Chinese okra), Momordica spp. (including balsam apple, balsam pear, bitter melon and Chinese cucumber), musk melon (including cantaloupe and pumpkin), summer squash and winter squash (including butternut squash, calabaza, giant squash, acorn squash, spaghetti squash) and watermelon; berries, such as blackberry (including bingoji blackberry, boisenberry, blackberry, low mulberry, marionberry, olalia and Young's hawthorn), blueberry, cranberry, currant, elderberry, currant, huckleberry, loganberry, raspberry and strawberry; oilseeds such as almond, beech nut, Brazil nut, cashew nut, chestnut, filbert (hazelnut), hickory nut, macadamia nut, pecan nut and walnut; Tropical fruits and other crops such as bananas, seedlings, mangoes, coconuts, papayas, guavas, avocados, lychees, agave, coffee, cocoa, sugar cane, oil palm, sesame, rubber and spices; fiber crops such as cotton, flax and hemp;Grasses (including warm-season and cool-season grasses), such as bentgrass, Kentucky bluegrass, St. Augustine grass, tall fescue, and Bermuda grasses.

[0233] In a further embodiment, the present method comprises treating cereal plants with an effective amount of captan as a fungicide.

[0234] In another embodiment, the method comprises treating cereal seeds with an effective amount of captan as a fungicide and at least one other fungicide selected from a demethylation inhibitor, external quinone inhibitor, succinate dehydrogenase inhibitor, internal quinone inhibitor or combinations thereof. Petition 870260041192, dated 04 / 05 / 2026, pages 153 / 172 64 / 77

[0235] In one embodiment, cereal plants comprise wheat and triticale.

[0236] The composition of the present invention comprising an effective amount of captan as a fungicide for effective control of Septoria tritici in cereal plants where the fungicides DMI and QoI have shown resistance.

[0237] In a preferred embodiment, the present invention relates to a method for controlling Septoria tritici resistant to DMI and QoI fungicides in wheat or triticale, comprising treating the plants, their seed or the soil with an effective amount of captan fungicide.

[0238] In another preferred embodiment, the method comprises treating wheat plants or plant propagation material thereof with an effective amount of captan fungicide.

[0239] As used herein, the term plant propagation material should be understood as denoting all parts of the plant that generate particular seeds.

[0240] In the preferred embodiment, the method comprises treating wheat seeds with an effective amount of captan fungicide, optionally with another fungicide selected from at least one other fungicide selected from a demethylation inhibitor, external quinone inhibitor, succinate dehydrogenase inhibitor, internal quinone inhibitor or combinations thereof.

[0241] In a more preferred embodiment, the present invention relates to a method for controlling Septoria tritici resistant to DMI fungicides in wheat, comprising treating the plants, their seed or the soil with an effective amount of captan fungicide. Petition 870260041192, dated 04 / 05 / 2026, pages 154 / 172 65 / 77

[0242] In a preferred embodiment, the method comprises treating wheat plants with an effective amount of captan fungicide.

[0243] In another preferred embodiment, the method comprises treating wheat seeds with an effective amount of captan fungicide.

[0244] According to the present invention, the treatment of plants, their seeds or soil in the method according to the present invention can be carried out by spray application, in seed treatment, in drip and immersion applications, in furrow applications, seed application and general incorporation into the soil, chemical mitigation, by adding the active ingredients to the irrigation water, and in hydroponic / mineral systems.

[0245] Typically, according to the present invention, effective as a fungicide against Septoria tritici means a significant reduction in primary infection by Septoria tritici, compared to the untreated plant, for example, a significant reduction in the range of about 50 to 90% compared to an untreated control plant), when compared to the untreated plant (100%).

[0246] In a preferred embodiment, the reduction in primary infection by Septoria tritici, compared with the untreated plant, is at least 50%, more preferably at least 60%, and even more preferably at least 70% when captan is used in an effective amount as a fungicide.

[0247] In one embodiment, the compositions described herein are used to control fungal diseases in wheat plants. Petition 870260041192, dated 04 / 05 / 2026, pages 155 / 172 66 / 77

[0248] In one embodiment, the effective amount of Captan applied is in the range of about 0.5 kg / ha to 2.5 kg / ha, preferably about 1.5 kg / ha to 2.0 kg / ha.

[0249] In one embodiment, Captan can be applied in an effective amount in a fungicidal manner so as to act as a synergist for the systemic fungicides of the present invention. However, the appropriate amounts of fungicides used in the present invention, whether multi-site contact fungicides or systemic fungicides, are not particularly limiting and can be conveniently chosen by one skilled in the art.

[0250] The control method of the present invention can be performed by spraying the suggested tank mixtures, or the individual fungicides can be formulated as a kit of parts containing several components that can be mixed as instructed before spraying.

[0251] In one embodiment, the fungicides or combinations thereof contemplated according to the present invention may be preformulated and may be in the form of water-dispersible granules (WDG), wettable powders, suspension concentrates, emulsifiable concentrates, suspoemulsions, capsule suspensions, etc. However, the choice of any preferred formulation type is not particularly limiting.

[0252] In a preferred embodiment, the composition of the present invention is formulated as a suspension concentrate (SC).

[0253] In a preferred embodiment, the suspension concentrates of the present invention comprise captan in an amount in the range of 400 g / l to 800 g / l, preferably 500 g / l. Petition 870260041192, dated 04 / 05 / 2026, pages 156 / 172 67 / 77

[0254] In one embodiment, the effective amount of active ingredient, preferably captan, is preferably 40% to 80% by weight, in particular 45% to 50% by weight, more preferably 50% to 55% by weight of the total weight of the composition.

[0255] In a preferred embodiment, the concentrated suspension composition is used to control Septoria titrici in cereal plants, for example, wheat plants.

[0256] In one embodiment, the amount of Captan used in the composition varies based on the type of formulation.

[0257] In one modality, the amount of Captan to be applied ranges from 0.1 l / ha to 5 l / ha, with 0.5 l / ha to 2.5 l / ha being preferred.

[0258] In a preferred embodiment, the compositions of the present invention comprise captan in an amount in the range of 0.2 l / ha to 2.0 l / ha, preferably 0.5 l / ha to 1.5 l / ha.

[0259] Adjuvants and auxiliary ingredients may be used to formulate such pre-formulated compositions and may employ humectants, adhesives, dispersants, or surfactants and, if appropriate, solvent or oil and other agriculturally acceptable additives and adjuvants.

[0260] In one embodiment, the present invention thus provides a composition comprising any of the fungicidal combinations as described herein together with agronomically acceptable excipients.

[0261] It is readily understood that the treatment method of the present invention can be used on all plants that are infected by the Septoria family. Such exemplary host plants may include cereal plants, for example, wheat. Petition 870260041192, dated 04 / 05 / 2026, pages 157 / 172 68 / 77

[0262] In a preferred embodiment, a method of treating infection caused by Septoria in wheat plants is provided.

[0263] Typically, the compositions and methods of the present invention are for the treatment and / or control of speckled leaf spot of wheat, Zymoseptoria tritici.

[0264] In some embodiments, captan can also be used together with fertilizers, such as ammonium nitrate, urea, potash and superphosphate, phytotoxic and plant growth regulators and protectors. These can be used sequentially or in combination with the compositions described above, if appropriate, also added immediately before use (tank mixing) and the plant (or plants) can be sprayed with a composition of this invention before or after being treated with the fertilizers.

[0265] As will be demonstrated in the examples, the multisite fungicide, for example, Captan or its combination with a systemic fungicide (or systemic fungicides) for the treatment of septoria leaf spot caused by Zymoseptoria tritici in wheat plants greatly affected disease control, as well as improved productivity.

[0266] The method of the present invention also improves control of existing disease to an unexpectedly high degree, and surprisingly improves yield. The method of the present invention also allows for greater control of resistance and reduces the amount of active ingredients used.

[0267] These and other advantages of the invention may become more apparent from the examples presented below in this document. These examples are provided merely as illustrations of the invention and are not intended to be interpreted as a limitation thereof. Petition 870260041192, dated 04 / 05 / 2026, pages 158 / 172 69 / 77 Examples Example 1: Captane Formulation (500 SC) INGREDIENTS QUANTITY (GMS / LIT) Captan 500 Polyarylphenyl ether phosphate amine salt 30 Solvent 80 Silicon-based organic polymer 3 Water QS Total 1 l

[0268] In the following examples, the deposited test is represented on the efficacy of captan and its mixtures with another fungicide on Septoria wheat. Example 2

[0269] A study was conducted to evaluate the efficacy of the multisite fungicide (Captan) against the pathogen Zymoseptoria tritici. Winter wheat plants cv. Alixan (Limagrain) at the BBCH 12 growth stage were treated with a hand-held sprinkler using 2 calibrated spray bars to deliver the equivalent of 200 l / ha. Three replicates (pots) of 6 wheat plants were used for all conditions tested. After treatment, the wheat plants were allowed to dry at room temperature for 1 hour and then placed in a climate chamber.

[0270] Twenty-four hours after treatment, 5 cm fragments of the first leaf are cut and transferred to a 90 mm Petri dish. Petition 870260041192, dated 04 / 05 / 2026, pages 159 / 172 70 / 77 diameter Petri dishes containing aqueous agar supplemented with an anti-senescence compound (7 leaf fragments per Petri dish). The leaf fragments are then inoculated with a brush dipped into the calibrated pycnoporus suspension of the Z. tritici Mg Tri-R6 strain.

[0271] After inoculation, the Petri dishes are placed in adapted climatic conditions.

[0272] Disease assessments are performed 21 and 28 days post-inoculation (dpi) by measuring the length of the necrosis and the total length of the leaf fragment. The infection intensity is then determined as a percentage of the total length of the leaf fragment. The infection intensity values ​​obtained are compared using the Newman and Keuls test (XL-Stat software, Addinsoft Ltd.).

[0273] The most commonly used method for estimating the area under the disease progress curve (AUDPC), the trapezoidal method, is performed. Fungicide efficacy was determined from infection intensity and AUDPC values ​​and expressed as a percentage of the untreated control. Formulation | Active Ingredient Quantity | Dosage Rates (g ai / ha) | Captan 800 WG | 80% ai / Kg | 800 | 1600 | Captan 800 WG | 80% ai / Kg | 2400 | 3200 | Chlorothalonil 500 SC | 500 g / l | 750 | Heliosoufre SC | 730 g / l | 4200 | Dithane Neotec WG | 75% / kg | 1600 | Control - Sterile distilled water Petition 870260041192, dated 04 / 05 / 2026, pages 160 / 172 71 / 77

[0274] It was observed that when Captan was applied, it showed very satisfactory fungicidal efficacy against the Zymoseptoria tritici Zt Tri-R6 strain, which is moderately resistant to DMI fungicides and highly resistant to QoI fungicides, at the lowest rate of 800 g / ha.

[0275] In fact, at this rate, Captan already exhibits 77% efficiency. At three rates tested (1600, 2400 and 3200 g / ha), Captan almost completely inhibits the development of this strain of Z. tritici in wheat leaf tissues (Figure 1). Example 3

[0276] Field trails in the combination of commercially available captan (500SC) with another fungicide:

[0277] A study was conducted to evaluate the effectiveness of mixtures of Captan with another fungicide against Septoria wheat. Combination mixtures were used as follows: Brief description of the results in the attached tables:

[0278] Figure 1: Percentage efficacy of the Zymoseptoria tritici Zt strain Tri-R6, moderately resistant to DMI and highly resistant to QoI fungicides, in untreated wheat leaf fragments or those preventively treated with Captan, Chlorothalonil, Sulfur, and Mancozeb under controlled conditions. Table 1 Active ingredient Dose (g ai / ha) Fungicidal efficacy against Zymoseptoria tritici (% control) Untreated - - Captan 800 77.9 Captan 1600 96.0 Petition 870260041192, dated 04 / 05 / 2026, pages 161 / 172 72 / 77 Captan 2400 97.0 Captan 3200 100 Chlorothalonil 750 69.2 Sulfur 4200 65.8 Mancozeb 1600 21.0

[0279] Table 2: Comparison of fungicidal efficacy, obtained from AUDPC values, of Difenoconazole (DFZ) used at 25 g / ha of direct or two-way mixtures with sulfur (S), Captan, Chlorothalonil (CTL), Mancozeb (MCZ) or Folpet and the two-way reference mixture of epoxiconazole + Folpet for Zymoseptoria tritici Zt Tri-R6 strain moderately resistant to DMI and highly resistant to QoI fungicides under controlled conditions. Table 2 Active ingredient (or active ingredients) Dose (g ai / ha) Fungicidal efficacy against Zymoseptoria tritici (% Control) Untreated - - Difenoconazole 25 81.8 Difenoconazole+Captan 25+160 93.4 Difenoconazole+Captan 25+240 97.5 Difenoconazole+folpet 25+150 93.1 Epoxiconazole+folpet 15+112.5 98.2 Epoxiconazole+folpet 20+150 99.6 Epoxiconazole+folpet 25+187.5 100

[0280] Table 3: Comparison of fungicidal efficacy, obtained from AUDPC values, of Prothioconazole (DFZ) used at 30 g / ha in mixtures Petition 870260041192, dated 04 / 05 / 2026, pages 162 / 172 73 / 77 direct or two-way mixtures with sulfur (S), Captan, Chlorothalonil (CTL), Mancozeb (MCZ) or Folpet and the two-way reference mixture of Opus + Folpet for Zymoseptoria tritici Zt Tri-R6 strain moderately resistant to DMI and highly resistant to QoI fungicides under controlled conditions. Table 3 Active ingredient Dose (g ai / ha) Fungicidal efficacy against Zymoseptoria tritici (%) Untreated - - Prothioconazole 30 68.2 Prothioconazole+Sulfur 30+371 87.6 Prothioconazole+Captan 30+120 97.3 Prothioconazole+Captan 30+180 98.3 Prothioconazole+Mancozeb 30+240 87.2 Prothioconazole+Folpet 30+112.5 92.6 Epoxiconazole+Folpet 15+112.5 98.2 Epoxiconazole+Folpet 20+150 99.6 Epoxiconazole+Folpet 25+187.7 100

[0281] Table 4: Comparison of fungicidal efficacy, obtained from AUDPC values, of Prothioconazole (DFZ) used at 22.5 g / ha of direct or two-way mixtures with sulfur (S), Captan, Chlorothalonil (CTL), Mancozeb (Mcz) or Folpet and the two-way reference mixture of epoxiconazole + Folpet for Zymoseptoria tritici Zt Tri-R6 strain moderately resistant to DMI and highly resistant to QoI fungicides under controlled conditions. Petition 870260041192, dated 04 / 05 / 2026, pages 163 / 172 74 / 77 Table 4 Active ingredient Dose (g ai / ha) Fungicidal efficacy against Zymoseptoria tritici (%) Untreated - - Prothioconazole 22.5 62.9 Prothioconazole+Captan 22.5+120 90.0 Prothioconazole+Captan 22.5+180 92.4 Prothioconazole+Mancozeb 22.5+240 78.0 Prothioconazole+folpet 22.5+112.5 92.2 Epoxiconazole+folpet 15+112.5 98.2 Epoxiconazole+folpet 20+150 99.6 Epoxiconazole+folpet 25+187.7 100

[0282] Table 5. Comparison of fungicidal efficacy, obtained from AUDPC values, Sulfur + Copper, GoActive® + sulfur + Cu or captan towards the Zymoseptoria tritici Zt Tri-R6 strain moderately resistant to DMI and highly resistant to Qol fungicides under controlled conditions. Table 5 Active ingredient Dose (g ai / ha) Fungicidal efficacy against Zymoseptoria tritici (%) Untreated - 0 Sulfur + copper at 2.7 l / ha 1728 Sulfur + copper 216 g / ha 71.6 GoActiv® (biostimulant) + Sulfur + Copper at 3 l / ha 282 Sulfur + copper 219 g / ha 10.7 Captan SC at 1.6 l / ha 800 g / ha 99.4 Petition 870260041192, dated 04 / 05 / 2026, pages 164 / 172 75 / 77

[0283] Thus, it was found that Captan alone and the combination of Captan with other fungicides are effective in controlling Septoria tritici. It was further found that combination mixtures are better than difenoconazole alone as there is no antagonism. Example 3

[0284] Two tests were conducted on winter wheat / Triticum aestivum (winter), variety ORIENTADOR, to evaluate the control of wheat speckled leaf spot (Spetoria titrici) as the primary target. All products were applied with a backpack sprayer using compressed air as a propellant. The sprayer was fitted with a boom and flat fan nozzles, and calibrated to apply a homogeneous spray volume at a constant pressure.

[0285] Application method: Application A: At the beginning of the disease attack and Application B: Renew the application when a new disease attack occurs in the best graphs, 3 weeks after application A (at least 2 weeks, at most 4 weeks). The results are shown in Table 6 and Table 7.

[0286] No adverse effects were observed at any time point during the duration of the tests. Test 1: Table 6 Fungicide efficacy against Zymoseptoria tritici (% of control) Treatment No. Treatment Rate (l / ha) 28 DA-B 28 DA-B Petition 870260041192, dated 04 / 05 / 2026, pages 165 / 172 76 / 77 1 Controle não tratado - 0.0 0.0 2 Protiocon azole 0.31 31.2 28.8 3 Captano 1.8 32.4 24.5 6 Protiocon azole + Captano 0.41+2.5 90.06 92.0 Protiocon azole + Captano 0.31+2.5 82.8 87.8 7 Protiocon azole + Captano 0.41+1, 8 80.9 79 Protiocon azole + Captano 0.21+2, 5 78.4 89.6 8 Protiocon azole + Captano 0.31+1, 8 77.5 92.3 Protiocon azole + Captano 0.41+1, 3 74.7 93.1 10 Protiocon azole + Captano 0.31+1.3 76.5 87.0 Protiocon azole + Captano 0.21+1.8 81.6 89.7 14 JOAO® (Protiocon azole EC) 0.8 78.3 92.4 15 JUVENT US® 1+1 77 85.3 16 KANTIK® 1.6 76.3 86.9 Petition 870260041192, de 04 / 05 / 2026, pag. 166 / 172 77 / 77 Test 2: Table 7 Fungicidal efficacy against Zymoseptoria tritici (% control) Treatment No. Rate / Unit Rate (l / ha) 26 DA-A 40 DA-A 40 DA-A 1 Untreated control - 0.0 0.0 0.0 2 Prothioconazole 0.31 42.3 40.7 58.4 3 Captan 1.8 41.3 31.9 25.7 6 Prothioconazole+Captan 0.41+2.5 76.0 89.9 86.1 7 Prothioconazole+Captan 0.31+2.5 85.8 71.1 72.0 8 Prothioconazole+Captan 0.41+1.8 81.5 76.1 83.6 10 Prothioconazole+Captan 0.31+1.8 60.8 78.7 82.7 11 Prothioconazole+Captan 0.41+1.3 66.1 79.9 84.5 14 JOAO® 0.8 58.4 75.8 80.4 15 JUVENTUS®+BRA VO® 1+1 64.0 72.5 88.5 16 KANTIK ® 1.6 45.1 68.1 74.2 Conclusion:

[0287] It was observed that all treatments showed satisfactory control of the disease that appeared on the leaf. In particular, a combination of captan + prothioconazole showed synergistic efficacy over soil products. No selectivity problems were observed during the test. No effect on non-target organisms was observed. Petition 870260041192, dated 04 / 05 / 2026, pp. 167 / 172

Claims

1 / 3 CLAIMS 1. Fungicidal composition for controlling zymoseptoria infection in plants, wherein said composition is characterized by comprising at least one phthalimide fungicide.

2. Composition according to claim 1, characterized in that said phthalimide fungicide is selected from captan, captafol, folpet or combinations thereof.

3. Composition according to claim 1, characterized in that said phthalimide fungicide is captan.

4. Composition according to claim 1, wherein said composition is characterized by being applied to cereal plants or to plant propagation material thereof to control Septoria caused by the pathogen Zymoseptoria tritici.

5. Composition according to claim 1, characterized by further comprising at least one other fungicide selected from a multi-site fungicide, a demethylation inhibitor, an external quinone inhibitor, a succinate dehydrogenase inhibitor, an internal quinone inhibitor or combinations thereof.

6. Composition according to claim 1, characterized in that said phthalimide fungicide is present in an amount ranging from 0.05 to 99%, by weight, of active compounds.

7. Fungicidal composition for controlling Zymoseptoria infection in cereal plants, characterized by comprising captan and at least one other fungicide selected from a multi-site fungicide, a demethylation inhibitor, an external quinone inhibitor, a succinate dehydrogenase inhibitor, an internal quinone inhibitor, or combinations thereof. Petition 870260041192, dated 04 / 05 / 2026, pp. 168 / 172 2 / 3 8. Composition according to claim 7, characterized by comprising (i) captan; and (ii) at least one demethylation inhibitor and one succinate dehydrogenase inhibitor.

9. Composition according to claim 7, characterized by comprising (i) captan and (ii) at least one succinate dehydrogenase inhibitor; and (iii) at least one external quinone inhibitor, an internal quinone inhibitor or a demethylation inhibitor.

10. Composition according to claim 7, characterized in that said captan is present in an amount of 10% to 70% by weight of the composition and another fungicide is present in an amount of 5% to 30% by weight of the composition.

11. Composition according to claim 7, wherein said composition is characterized by being formulated as a solid formulation or liquid formulation together with agrochemically acceptable excipients.

12. Use of captan characterized as being to improve disease control in plants infected with Zymoseptoria.

13. Use of the composition to control Zymoseptoria infection in cereal plants, characterized by comprising captan and at least one other multisite fungicide or an external quinone inhibitor or an internal quinone inhibitor or a demethylation inhibitor or a succinate dehydrogenase inhibitor or combinations thereof. Petition 870260041192, dated 04 / 05 / 2026, pp. 169 / 172 3 / 3 14. Method for treating zymoseptoria infection in cereal plants or their seeds or in the soil with a composition characterized by comprising: applying to the plant a fungicidal composition comprising the effective amount of captan as a fungicide.

15. Method according to claim 14, characterized in that said infection by zymoseptoria is zymoseptoria tritici.

16. Method for controlling Zymoseptoria infection in a plant or its seeds or in the soil, wherein the method is characterized by comprising applying to the plant site a combination comprising: captan and at least one fungicide selected from among a multi-site fungicide, an external quinone inhibitor, an internal quinone inhibitor, a demethylation inhibitor, a succinate dehydrogenase inhibitor or combinations thereof. Petition 870260041192, dated 04 / 05 / 2026, pp. 170 / 172

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