Transcranial magnetic stimulation system and method

Abstract

This invention discloses a transcranial magnetic stimulation (TMS) system and method. The system includes a head data acquisition module, a stimulation subject simulation module, and a coil parameter recommendation module. The head data acquisition module acquires head data of the target stimulation subject, including scalp data, skull data, and brain tissue data. The stimulation subject simulation module, connected to the head data acquisition module, constructs a head model of the target stimulation subject based on the acquired head data. The coil parameter recommendation module, connected to the stimulation subject simulation module, generates coil structure test parameters and performs simulation tests on the head model based on preset stimulation parameters and coil structure test parameters to obtain test data. Based on the test data, a TMS coil adapted to the head model is determined. Through the technical solution of this invention, the technical effect of improving the compatibility between the TMS coil and the target stimulation subject is achieved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of transcranial magnetic stimulation, and particularly to a transcranial magnetic stimulation system and method. BACKGROUND

[0002] Transcranial magnetic stimulation (TMS) technology has become a non-invasive effective examination and treatment method in the fields of biomedical research and neurology research.

[0003] At present, when a transcranial magnetic stimulation instrument is used to perform transcranial magnetic stimulation on a target object, if a transcranial magnetic stimulation coil is not suitable for the target object, the focusing property and the stimulation intensity cannot meet the requirements of the transcranial magnetic stimulation. For example, when a transcranial magnetic stimulation is performed on a small animal, a transcranial magnetic stimulation coil suitable for a large animal is used for stimulation, which can cause poor focusing property and excessively high stimulation intensity, and it is difficult to accurately perform the transcranial magnetic stimulation. SUMMARY

[0004] The present application provides a transcranial magnetic stimulation system and method to solve the problem that a transcranial magnetic stimulation coil is not suitable for a target stimulation object, and achieve the technical effect of improving the adaptation of a transcranial magnetic stimulation coil to a target stimulation object.

[0005] According to an aspect of the present application, a transcranial magnetic stimulation system is provided, which comprises a head data acquisition module, a stimulation object simulation module and a coil parameter recommendation module, wherein

[0006] The head data acquisition module is configured to acquire head data of a target stimulation object, wherein the head data comprises scalp data, skull data and brain tissue data.

[0007] The stimulation object simulation module is connected to the head data acquisition module and configured to construct a head model of the target stimulation object according to the acquired head data.

[0008] The coil parameter recommendation module is connected to the stimulation object simulation module and configured to generate coil structure test parameters, perform simulation test on the head model according to preset stimulation parameters and the coil structure test parameters, obtain test data, and determine a transcranial magnetic stimulation coil suitable for the head model according to the test data.

[0009] According to another aspect of the present application, a transcranial magnetic stimulation method is provided, which is applied to a transcranial magnetic stimulation system comprising a head data acquisition module, a stimulation object simulation module connected to the head data acquisition module and a coil parameter recommendation module connected to the stimulation object simulation module, wherein the transcranial magnetic stimulation method comprises:

[0010] acquire head data of the target stimulation object through the head data acquisition module, wherein the head data comprises scalp data, skull data and brain tissue data;

[0011] construct a head model of the target stimulation object according to the acquired head data through the stimulation object simulation module;

[0012] generate coil structure test parameters through the coil parameter recommendation module, and perform simulation test on the head model according to preset stimulation parameters and the coil structure test parameters to obtain test data, and determine a transcranial magnetic stimulation coil adapted to the head model according to the test data.

[0013] The technical scheme of the embodiment of the application acquires head data of the target stimulation object through the head data acquisition module, constructs a head model of the target stimulation object according to the acquired head data through the stimulation object simulation module, generates coil structure test parameters through the coil parameter recommendation module, and performs simulation test on the head model according to preset stimulation parameters and the coil structure test parameters to obtain test data, and determines a transcranial magnetic stimulation coil adapted to the head model according to the test data, thereby solving the problem that the transcranial magnetic stimulation coil is not adapted to the target stimulation object, and achieving the technical effect of improving the adaptation degree of the transcranial magnetic stimulation coil to the target stimulation object.

[0014] It should be understood that the content described in this part is not intended to identify key or important features of the embodiments of the application, nor is it used to limit the scope of the application. Other features of the application will become apparent from the following description.

[0015] The technical scheme of the application will be described in further detail below with reference to the drawings and embodiments. BRIEF DESCRIPTION OF DRAWINGS

[0016] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the application and, together with the description, serve to explain the principles of the application.

[0017] The application can be more clearly understood and appreciated from the following detailed description, taken in conjunction with the accompanying drawings, in which:

[0018] Figure 1 a structure schematic view of a transcranial magnetic stimulation system provided by the embodiment one of the application;

[0019] Figure 2 a flowchart of a method for determining a transcranial magnetic stimulation coil adapted to a small animal provided by the embodiment one of the application;

[0020] Figure 3 another structure schematic view of a transcranial magnetic stimulation system provided by the embodiment one of the application;

[0021] Figure 4 A circuit diagram of a magnetic stimulation driving circuit of a transcranial magnetic stimulation system according to an embodiment of the present application;

[0022] Figure 5 A main circuit block diagram of a transcranial magnetic stimulation system according to an embodiment of the present application;

[0023] Figure 6 A flowchart of a transcranial magnetic stimulation method according to an embodiment of the present application. DETAILED DESCRIPTION

[0024] Various exemplary embodiments of the present application will now be described in detail with reference to the accompanying drawings. It should be noted that the relative arrangement of the components and steps set forth in the embodiments, numerical expressions, and numerical values are not limiting to the scope of the present application unless otherwise specifically stated.

[0025] It should be understood, of course, that the various embodiments of the present application are not limited to the illustrations described above, but can vary the steps of the methods and the components and parameters of the systems described and / or shown.

[0026] The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way limiting to the scope of the application and its applications or uses.

[0027] Techniques, methods, and apparatus known to those of ordinary skill in the relevant art can not be discussed in detail herein. However, where appropriate, such techniques, methods, and apparatus can be considered part of the present application.

[0028] It should be noted that like reference numerals and letters refer to like items in the drawings and that a discussion of an item in one drawing does not preclude further discussion of that item in a subsequent drawing.

[0029] Embodiment One

[0030] Figure 1 A structural schematic diagram of a transcranial magnetic stimulation system according to an embodiment of the present application, the present embodiment can be applied to the case of selecting a suitable transcranial magnetic stimulation coil according to a target stimulation object, the system can be used to perform a transcranial magnetic stimulation method, the system can be realized in the form of hardware and / or software, and the system can be configured in an electronic device.

[0031] As shown in the figure, the system includes a head data acquisition module 1, a stimulation object simulation module 2, and a coil parameter recommendation module 3. Figure 1

[0032] ​The head data acquisition module 1 is configured to acquire head data of a target stimulation object, wherein the head data comprises scalp data, skull data and brain tissue data.

[0033] The head data acquisition module 1 is configured to acquire head data of a target stimulation object.

[0034] The target stimulation object can be an object to be subjected to transcranial magnetic stimulation, and can be a small animal such as a mouse. The head data can be head data acquired based on a medical information acquisition device, and comprises scalp data, skull data and brain tissue data. For example, the head data can be head images acquired based on brain CT (Computed Tomography) or MRI (Magnetic Resonance Imaging).

[0035] Specifically, the head data of the target stimulation object can be acquired based on a medical information acquisition device, or can be pre-uploaded or downloaded head data of the target stimulation object. The head data of the target stimulation object can also be acquired by other means, which is not specifically limited in the embodiment.

[0036] The stimulation object simulation module 2 is connected with the head data acquisition module 1 and configured to construct a head model of the target stimulation object according to the acquired head data.

[0037] The head model can be a three-dimensional model simulating the head structure of the target stimulation object.

[0038] Specifically, the stimulation object simulation module 2 can acquire the acquired head data from the head data acquisition module 1, and analyze and process the acquired head data to construct the head model of the target stimulation object for subsequent simulation testing.

[0039] The coil parameter recommendation module 3 is connected with the stimulation object simulation module 2 and configured to generate coil structure test parameters, and perform simulation testing on the head model according to the preset stimulation parameters and the coil structure test parameters to obtain test data, and determine a transcranial magnetic stimulation coil adapted to the head model according to the test data.

[0040] The coil structure test parameters can be parameters used when constructing the transcranial magnetic stimulation coil, and can include coil inductance, coil resistance, coil turns, wire material, wire diameter, and the like. If the transcranial magnetic stimulation coil is a conical coil, the coil structure test parameters can further include a bottom radius of the conical coil and a top radius of the conical coil, and the like. The preset stimulation parameters can be parameters for generating a stimulation electric signal that are set in advance according to a transcranial magnetic stimulation requirement, and can include magnetic stimulation intensity, magnetic stimulation frequency, magnetic stimulation time, magnetic stimulation mode, and the like. The test data can be data obtained during the simulation test and at the end of the simulation test.

[0041] Specifically, the coil parameter recommendation module 3 can generate coil structure test parameters, which can be default parameters or parameters pre-configured through experience. The coil structure test parameters generated by the coil parameter recommendation module 3 are used as parameters for constructing an initial transcranial magnetic stimulation coil. The coil parameter recommendation module 3 can obtain a head model of a target stimulation object from the stimulation object simulation module 2, perform simulation testing on the head model based on the preset stimulation parameters and the coil structure test parameters, and obtain test data. Further, it is determined whether the test data meets the current transcranial magnetic stimulation requirement. If yes, one of a plurality of transcranial magnetic stimulation coils that is most matched with the current coil structure test parameters is selected as a transcranial magnetic stimulation coil adapted to the head model. If not, the coil structure test parameters are adjusted, and the simulation testing on the head model is performed again to further determine whether the test data obtained after adjusting the coil structure test parameters meets the current transcranial magnetic stimulation requirement.

[0042] Optionally, the coil parameter recommendation module 3 is specifically configured to perform electromagnetic field simulation testing on the head model according to the preset stimulation parameters and the coil structure test parameters, obtain an electromagnetic field spatial distribution corresponding to the head model, and determine a transcranial magnetic stimulation coil adapted to the head model according to the electromagnetic field spatial distribution.

[0043] The electromagnetic field simulation testing can be simulation testing of an electromagnetic field in the head model when the transcranial magnetic stimulation coil constructed by the coil structure test parameters generates a stimulation electric signal of the transcranial magnetic stimulation based on the preset stimulation parameters. The electromagnetic field spatial distribution can be a distribution of an electromagnetic field generated by the simulated transcranial magnetic stimulation in the head model.

[0044] Specifically, the coil parameter recommendation module 3 can perform electromagnetic field simulation test on the head model based on the preset stimulation parameter and the coil structure test parameter, and obtain the electromagnetic field spatial distribution corresponding to the head model in the test process. Further, it is judged whether the electromagnetic field spatial distribution matches the current electromagnetic field spatial distribution requirement of transcranial magnetic stimulation. If it matches, the coil structure test parameter that matches the head model is selected from the pre-stored transcranial magnetic stimulation coils. If it does not match, the coil structure test parameter is adjusted, and the electromagnetic field simulation test on the head model is performed again to further judge whether the electromagnetic field spatial distribution corresponding to the head model after adjusting the coil structure test parameter matches the current electromagnetic field spatial distribution requirement of transcranial magnetic stimulation.

[0045] Optionally, the coil parameter recommendation module 3 is further configured to adjust the coil structure test parameter according to the electromagnetic field spatial distribution and the preset stimulation target position to obtain the coil structure test parameter that matches the head model, and determine the transcranial magnetic stimulation coil corresponding to the coil structure test parameter as the matched transcranial magnetic stimulation coil.

[0046] The preset stimulation target position can be a stimulation target position in subsequent transcranial magnetic stimulation.

[0047] Specifically, the coil parameter recommendation module 3 can determine whether the electromagnetic field at the preset stimulation target position meets the requirement of subsequent transcranial magnetic stimulation according to the electromagnetic field spatial distribution. And the coil structure test parameter can be adjusted according to the requirement and the electromagnetic field at the preset stimulation target position. One or more of the bottom radius of the conical coil, the top radius of the conical coil, the coil inductance, the coil resistance, the coil turns, the wire material and the wire diameter can be adjusted to make the electromagnetic field at the preset stimulation target position meet the requirement. If it meets the requirement, the current coil structure test parameter is determined as the coil structure test parameter that matches the head model, and then the coil structure test parameter that matches the head model is selected from the pre-stored transcranial magnetic stimulation coils. If it does not match, the coil structure test parameter is adjusted, and the electromagnetic field simulation test on the head model is performed again to further judge whether the electromagnetic field at the preset stimulation target position after adjusting the coil structure test parameter meets the requirement of subsequent transcranial magnetic stimulation.

[0048] Optionally, the head data acquisition module 1 is specifically configured to acquire head magnetic resonance data of a target stimulation object; and the stimulation object simulation module 2 is specifically configured to construct a head model of the target stimulation object according to brain tissue conductivity and dielectric constant information through the head magnetic resonance data.

[0049] Specifically, the head data acquisition module 1 can obtain the head magnetic resonance data of the target stimulation object. The stimulation object simulation module 2 can obtain the brain tissue conductivity and dielectric constant information of the target stimulation object, and construct a head model of the target stimulation object according to the brain tissue conductivity and dielectric constant information and the head magnetic resonance data obtained from the head data acquisition module 1.

[0050] Figure 2 A flowchart of a method for determining a small animal-adapted transcranial magnetic stimulation coil according to the first embodiment of the present application is shown.

[0051] Specifically, when determining a small animal-adapted transcranial magnetic stimulation coil, a real small animal simulation head model is first established. The brain tissue conductivity and dielectric constant information obtained from the previous biological tissue electrical property research of small animals can be used to establish the small animal simulation head model by image segmentation of small animal data (such as MRI data) to obtain each brain tissue structure. Then, a transcranial magnetic stimulation coil is constructed according to the coil structure test parameters, and joint simulation is performed based on the constructed transcranial magnetic stimulation coil and the small animal simulation head model. At this time, the joint simulation can be performed using preset stimulation parameters, and the electromagnetic field spatial distribution is analyzed to optimize the coil structure test parameters. The coil evaluation index can include one or more of focusing, field strength, heating, and mechanical stress. The coil structure test parameters can be optimized based on the particle swarm algorithm and the entropy weight method. Finally, the small animal-adapted transcranial magnetic stimulation coil can be matched according to the optimized coil structure test parameters.

[0052] In the above manner, the transcranial magnetic stimulation coil can be adapted to small animals. Due to the characteristics of small animals, a conical transcranial magnetic stimulation coil with good focusing and shallow stimulation depth can be selected as the target to match a transcranial magnetic stimulation coil adapted to small animals.

[0053] It should be noted that through computer simulation design, the electromagnetic field influence of the coil structure formed by different coil structure test parameters on the head model can be analyzed, so that the coil structure is well compatible with the main circuit of the transcranial magnetic stimulation system.

[0054] Based on the above examples, after determining the transcranial magnetic stimulation coil, the preset stimulation parameters can be adjusted through joint simulation of the transcranial magnetic stimulation coil and the small animal simulation head model, so that the stimulation parameters are more adapted to subsequent transcranial magnetic stimulation.

[0055] Optionally, as shown in Figure 3 The transcranial magnetic stimulation system further includes a magnetic stimulation control circuit 4, a magnetic stimulation driving circuit 5, and a transcranial magnetic stimulation coil 6.

[0056] The magnetic stimulation control circuit 4 is configured to generate a magnetic stimulation control signal, wherein the magnetic stimulation control signal comprises a magnetic stimulation frequency and a magnetic stimulation intensity; the stimulation driving circuit 5 is connected with the magnetic stimulation control circuit 4 and the transcranial magnetic stimulation coil 6, and is configured to generate a stimulation electric signal according to the magnetic stimulation control signal and transmit the stimulation electric signal to the transcranial magnetic stimulation coil 6; and the transcranial magnetic stimulation coil 6 is arranged on the head of the target stimulation object and is configured to act the received stimulation electric signal on the head of the target stimulation object.

[0057] Specifically, the magnetic stimulation control circuit 4 can generate a corresponding magnetic stimulation control signal according to a pre-configured magnetic stimulation frequency and a magnetic stimulation intensity. The stimulation driving circuit 5 can obtain the magnetic stimulation control signal from the magnetic stimulation control circuit 4, convert the magnetic stimulation control signal into a stimulation electric signal, and transmit the converted stimulation electric signal to the transcranial magnetic stimulation coil 6, so that the transcranial magnetic stimulation coil 6 can perform transcranial magnetic stimulation. The transcranial magnetic stimulation coil 6 can be arranged on the head of the target stimulation object and act the received stimulation electric signal on the head of the target stimulation object, so as to stimulate the pre-set stimulation target point position in the head.

[0058] As shown in FIG. 1, the magnetic stimulation driving circuit of the transcranial magnetic stimulation system mainly comprises a control circuit, a charging circuit, a discharging circuit and the like. By controlling the time of the charging and discharging switches, the width of the pulse current of the current of the transcranial magnetic stimulation coil 6, the stimulation amplitude, the stimulation frequency and other parameters can be controlled, thereby improving the use efficiency in actual application. Figure 4 As shown in FIG. 2, the main circuit of the magnetic stimulation driving circuit is divided into a charging circuit l1, a discharging circuit l2, a freewheeling circuit l3, a control switch and other parts. The charging circuit l1 comprises a power supply V1, a resistor R1, a control switch Q1, a capacitor C1, a capacitor C3 and an inductor L4. The discharging circuit l2 comprises the capacitor C1, a capacitor C2, a capacitor C4, a capacitor C5, an inductor L1, an inductor L2, an inductor L3, an inductor L5, a control switch Q2, a resistor R2, a resistor R3 and a diode D1. The freewheeling circuit l3 comprises the resistor R2, the resistor R3, the inductor L1, the inductor L3, the diode D1 and the capacitor C5.

[0059] Figure 4

[0060] ​​The control switches Q1 and Q2 can be IGBT (Insulated Gate Bipolar Transistor), for example: IRGPH50F, etc. By controlling the conduction or closure, the working state of the charging circuit, the freewheeling circuit and the discharging circuit is controlled, so that the discharging circuit is disconnected when the capacitor is charged, and the charging circuit is disconnected when the capacitor is discharged, which not only saves electric energy but also avoids the problem of damage to components caused by too long charging time. According to the timing characteristics of IGBT, the circuit can be divided into four states: (1) charging stage; (2) dead zone stage; (3) discharging stage; (4) freewheeling stage.

[0061] It should be noted that the whole TMS circuit is controlled by the stimulation mode around the control of the magnetic stimulation frequency of TMS, the magnetic stimulation intensity, etc. A single-chip microcomputer can be selected as the main control chip to control the working state of the IGBT by outputting PWM waves of different frequencies. In order to prevent damage to components caused by excessive pulse current, protection circuits can be designed for each part of the circuit, such as IGBT protection, capacitor protection, etc.

[0062] Optionally, the transcranial magnetic stimulation coil is a conical magnetic stimulation coil, and the conical magnetic stimulation coil is provided with a zinc-manganese ferrite at the center.

[0063] It should be noted that due to different pathologies and different brain regions, the conical magnetic stimulation coil has good focusing property, and the relatively shallow stimulation depth can be adapted to the small brain of a small animal. The small radius of the bottom part of the conical magnetic stimulation coil is beneficial to stimulating a specific brain region of a small animal (such as a mouse, etc.), and the focusing property is very good, but the stimulation intensity is not enough. Therefore, a zinc-manganese ferrite is placed inside the conical magnetic stimulation coil, and the zinc-manganese ferrite has high magnetic permeability, which can concentrate most of the magnetic field inside and outside the coil inside the zinc-manganese ferrite, further enhancing the stimulation intensity. This special structure design and the larger size of the upper coil make the electric field generated by the conical coil have good focusing property and maintain sufficient stimulation intensity at the brain.

[0064] Optionally, as shown in Figure 3 The transcranial magnetic stimulation system further comprises a temperature measuring component 7 and a heat dissipation device 8 arranged on the stimulation driving circuit 5 and / or the transcranial magnetic stimulation coil 6.

[0065] The temperature measuring component 7 is used to measure the temperature of the stimulation driving circuit 5 and / or the transcranial magnetic stimulation coil 6; the heat dissipation device 8 is used to adjust the heat dissipation intensity according to the temperature of the stimulation driving circuit 5 and / or the transcranial magnetic stimulation coil 6, so as to perform heat dissipation treatment on the stimulation driving circuit 5 and / or the transcranial magnetic stimulation coil 6.

[0066] In this embodiment of the invention, the heat dissipation intensity of the heat dissipation device 8 can be automatically adjusted according to the temperature. The advantage of this setting is that it can ensure that the stimulation driving circuit 5 and / or the transcranial magnetic stimulation coil 6 are always within a stable temperature range, reduce the impact of high temperature on the stimulation driving circuit 5 and the transcranial magnetic stimulation coil 6, and provide a guarantee for the safe operation of the stimulation driving circuit 5 and the transcranial magnetic stimulation coil 6.

[0067] Specifically, the temperature of the stimulation drive circuit 5 and / or the transcranial magnetic stimulation coil 6 can be measured by the temperature measuring component 7, wherein the temperature measurement can be performed by a thermometer, thermometer or other temperature measuring element.

[0068] Optionally, the heat dissipation device 8 can acquire the temperature measured by the temperature measuring component 7 and compare the temperature with a preset temperature threshold. If the temperature of the stimulation driving circuit 5 and / or the transcranial magnetic stimulation coil 6 exceeds the preset temperature threshold, a heat dissipation operation is initiated to dissipate heat from the stimulation driving circuit 5 and / or the transcranial magnetic stimulation coil 6.

[0069] It should be noted that the preset temperature thresholds of the stimulation drive circuit 5 and the transcranial magnetic stimulation coil 6 can be the same or different, and can be set according to actual operation.

[0070] It should also be noted that the heat dissipation device 8 can be considered as a cooling system. Without a cooling system, the transcranial magnetic stimulation coil 6 can only operate for a very short time under high-frequency stimulation. In order to effectively reduce the temperature of the transcranial magnetic stimulation coil 6, meet the requirements for long-term use, and not affect the health of the target stimulation object (such as small animals), a water-cooling system can be used. The water-cooling system can consist of three parts: a water pump, a water tank, and water pipes. Specifically, the water pipes can be connected to the transcranial magnetic stimulation coil 6 and a temperature measuring component 7 (such as a digital thermometer) can be placed there to control the working intensity of the cooling system.

[0071] For example, such as Figure 5 As shown, the main circuit of the transcranial magnetic stimulation (TMS) system includes a charging power supply, a control circuit, a charging switch, an energy storage capacitor, a discharge switch, a protection circuit, a stimulation coil, and a cooling system. It also includes a charging circuit, a discharge circuit, and a freewheeling circuit. The main function of the charging power supply is to provide electrical energy input to the control circuit and stimulation coil, and its output voltage is adjustable. The control circuit mainly consists of a microcontroller and peripheral circuits, used to adjust the frequency and intensity of the magnetic stimulation. The protection circuit protects the charging power supply, energy storage capacitor, and various switching devices from damage due to excessive pulse current. The cooling system cools the drive circuit and stimulation coil, preventing overheating of the stimulation coil due to prolonged use and ensuring normal system operation.

[0072] It should be noted that the shell material of the transcranial magnetic stimulation system can be made of good high temperature resin, which has three functions of support, insulation and cooling. In order to cool the coil as soon as possible, the shell is equipped with a cooling system, which effectively reduces the temperature of the coil and meets the demand of long time use.

[0073] Optionally, as shown in Figure 3 The transcranial magnetic stimulation system further comprises a user operation device 9.

[0074] The user operation device 9 is connected with the stimulation control circuit 4, and is configured to receive a transcranial magnetic stimulation parameter input by a user and send the transcranial magnetic stimulation parameter to the stimulation control circuit 4; the stimulation control circuit 4 is further configured to generate a magnetic stimulation control signal according to the transcranial magnetic stimulation parameter.

[0075] The transcranial magnetic stimulation parameter can be determined by the user according to subsequent transcranial magnetic stimulation to be performed.

[0076] Specifically, the user can set the transcranial magnetic stimulation parameter through the user operation device 9, and when the user operation device 9 receives the transcranial magnetic stimulation parameter input by the user, the user operation device 9 sends the transcranial magnetic stimulation parameter to the stimulation control circuit 4. In this case, the stimulation control circuit 4 can generate a magnetic stimulation control signal according to the transcranial magnetic stimulation parameter sent by the user operation device 9, so as to subsequently perform transcranial magnetic stimulation.

[0077] Optionally, as shown in Figure 3 The user operation module 9 comprises a parameter selection module 91 and a display module 92, and the parameter selection module 91 comprises a stimulation parameter setting element 911 and a stimulation mode selection element 912.

[0078] The display module 92 is configured to display the transcranial magnetic stimulation parameter input by the user; the stimulation parameter setting element 911 is configured to set at least one stimulation parameter of a magnetic stimulation frequency, a magnetic stimulation intensity and a magnetic stimulation time; and the stimulation mode selection element 912 is configured to select at least one preset stimulation mode.

[0079] The preset stimulation mode can be a combination of the magnetic stimulation frequency, the magnetic stimulation intensity and the magnetic stimulation time to form different stimulation modes.

[0080] Specifically, the user can set at least one stimulation parameter of the magnetic stimulation frequency, the magnetic stimulation intensity and the magnetic stimulation time through the stimulation parameter setting element 911, and the user can also select at least one preset stimulation mode through the stimulation mode selection element 912. Furthermore, the display module 92 can display the transcranial magnetic stimulation parameter set by the user, so that the user can intuitively view and confirm.

[0081] Exemplary, the user operation module 9 realizes the functions of encapsulating the core circuit and selecting the stimulation parameters as a whole. The user operation module 9 integrates various functions, and the shell can be a plastic structure, and the specific structure can be selected according to actual needs. A display module 92, such as a small display screen, can be carried in the user operation module 9 to display the parameters such as the magnetic stimulation frequency, the magnetic stimulation intensity, and the magnetic stimulation time. Further, a stimulation mode selection element 912 (such as a plurality of buttons, knobs, etc.) can be added on the shell to set the parameters such as the magnetic stimulation frequency, the magnetic stimulation intensity, the magnetic stimulation time, and the stimulation mode. By adding the stimulation mode selection function, the user can select the preset stimulation mode according to actual needs. By combining the magnetic stimulation frequency and the magnetic stimulation intensity, different preset stimulation modes can be formed, such as fixed-intensity fixed-frequency stimulation, enhanced frequency stimulation, etc. For example, the magnetic stimulation frequency can be set to 7 selection ranges of 0.1 Hz, 0.2 Hz, 0.3 Hz, 0.5 Hz, 1.0 Hz, 2.0 Hz, and 5.0 Hz, and the magnetic stimulation intensity can be set to 0.1 T, 0.2 T, 0.3 T, 0.4 T, and 0.5 T. Therefore, the user operation module 9 can be connected with the magnetic stimulation control circuit 4 in a wired manner, so that the user can flexibly select the transcranial magnetic stimulation parameters.

[0082] The technical scheme of the embodiment of the present application acquires head data of a target stimulation object through a head data acquisition module, constructs a head model of the target stimulation object according to the acquired head data through a stimulation object simulation module, generates coil structure test parameters through a coil parameter recommendation module, and performs simulation testing on the head model according to the preset stimulation parameters and the coil structure test parameters to obtain test data, and determines a transcranial magnetic stimulation coil adapted to the head model according to the test data, thereby solving the problem of inadaptation of the transcranial magnetic stimulation coil to the target stimulation object and achieving the technical effect of improving the adaptation degree of the transcranial magnetic stimulation coil to the target stimulation object.

[0083] Embodiment two

[0084] Figure 6 A flowchart of a transcranial magnetic stimulation method provided by the embodiment two of the present application is shown in the figure. The method is applied to a transcranial magnetic stimulation system, and the transcranial magnetic stimulation system comprises a head data acquisition module, a stimulation object simulation module connected with the head data acquisition module, and a coil parameter recommendation module connected with the stimulation object simulation module.

[0085] As shown in the figure, Figure 6 The method of the embodiment specifically comprises the following steps:

[0086] S610, acquiring head data of a target stimulation object through a head data acquisition module.

[0087] The head data comprises scalp data, skull data, and brain tissue data.

[0088] S620, constructing a head model of the target stimulation object according to the obtained head data by the stimulation object simulation module.

[0089] S630, generating a coil structure test parameter by the coil parameter recommendation module, and performing simulation test on the head model according to the preset stimulation parameter and the coil structure test parameter to obtain test data, and determining a transcranial magnetic stimulation coil adapted to the head model according to the test data.

[0090] Optionally, the coil parameter recommendation module performs electromagnetic field simulation test on the head model according to the preset stimulation parameter and the coil structure test parameter to obtain an electromagnetic field spatial distribution corresponding to the head model, and determines a transcranial magnetic stimulation coil adapted to the head model according to the electromagnetic field spatial distribution.

[0091] Optionally, the coil parameter recommendation module adjusts the coil structure test parameter according to the electromagnetic field spatial distribution and a preset stimulation target point position to obtain a coil structure test parameter adapted to the head model, and determines a transcranial magnetic stimulation coil corresponding to the coil structure test parameter as the adapted transcranial magnetic stimulation coil.

[0092] Optionally, the transcranial magnetic stimulation system further comprises a magnetic stimulation control circuit, a magnetic stimulation driving circuit and a transcranial magnetic stimulation coil, the stimulation driving circuit is connected with the magnetic stimulation control circuit and the transcranial magnetic stimulation coil, and the transcranial magnetic stimulation coil is arranged on the head of the target stimulation object; the magnetic stimulation control circuit generates a magnetic stimulation control signal, wherein the magnetic stimulation control signal comprises a magnetic stimulation frequency and a magnetic stimulation intensity; the stimulation driving circuit generates a stimulation electric signal according to the magnetic stimulation control signal and transmits the stimulation electric signal to the transcranial magnetic stimulation coil; and the transcranial magnetic stimulation coil acts on the head of the target stimulation object with the received stimulation electric signal.

[0093] Optionally, the transcranial magnetic stimulation coil is a conical magnetic stimulation coil, and the conical magnetic stimulation coil is provided with zinc-manganese ferrite at the center.

[0094] Optionally, the transcranial magnetic stimulation system further comprises that the stimulation driving circuit and / or the transcranial magnetic stimulation coil are provided with a temperature measuring component and a heat dissipation device; the temperature measuring component measures the temperature of the stimulation driving circuit and / or the transcranial magnetic stimulation coil; and the heat dissipation device adjusts the heat dissipation intensity according to the temperature of the stimulation driving circuit and / or the transcranial magnetic stimulation coil to perform heat dissipation treatment on the stimulation driving circuit and / or the transcranial magnetic stimulation coil.

[0095] Optionally, the transcranial magnetic stimulation system further comprises a user operation device connected with the stimulation control circuit; receiving the transcranial magnetic stimulation parameters input by the user operation device and sending the transcranial magnetic stimulation parameters to the stimulation control circuit; generating the magnetic stimulation control signal according to the transcranial magnetic stimulation parameters by the stimulation control circuit.

[0096] Optionally, the user operation module comprises a parameter selection module and a display module, the parameter selection module comprises a stimulation parameter setting element and a stimulation mode selection element; the transcranial magnetic stimulation parameters input by the user are displayed by the display module; at least one of the magnetic stimulation frequency, the magnetic stimulation intensity and the magnetic stimulation time is set by the stimulation parameter setting element; at least one of the preset stimulation modes is selected by the stimulation mode selection element.

[0097] Optionally, the head magnetic resonance data of the target stimulation object is acquired by the head data acquisition module; the head model of the target stimulation object is constructed by the stimulation object simulation module according to the brain tissue conductivity and dielectric constant information and the head magnetic resonance data.

[0098] The technical scheme of the embodiment of the application acquires the head data of the target stimulation object by the head data acquisition module, constructs the head model of the target stimulation object according to the acquired head data by the stimulation object simulation module, generates the coil structure test parameters by the coil parameter recommendation module, and simulates and tests the head model according to the preset stimulation parameters and the coil structure test parameters to obtain the test data, and determines the transcranial magnetic stimulation coil adapted to the head model according to the test data, thereby solving the problem that the transcranial magnetic stimulation coil is not adapted to the target stimulation object and achieving the technical effect of improving the adaptation degree of the transcranial magnetic stimulation coil to the target stimulation object.

[0099] Each of the embodiments in the specification is described in a progressive manner, and each embodiment focuses on the difference from other embodiments, and the same or similar parts of each embodiment can be referred to each other. For the system embodiment, since it is basically corresponding to the method embodiment, the description is relatively simple, and the relevant parts can be referred to the part of the method embodiment.

[0100] The methods and systems of the present application can be implemented in a number of ways. For example, the methods and systems of the present application can be implemented via software, hardware, firmware, or any combination of software, hardware, and firmware. The above described order of steps for the methods is merely illustrative, and the steps of the methods of the present application are not limited to the order specifically described above unless otherwise specifically stated. Furthermore, in some embodiments, the present application can also be implemented as a program recorded on a recording medium, which includes machine readable instructions for implementing the methods according to the present application. Thus, the present application also covers recording media storing programs for executing the methods according to the present application.

[0101] The description of the present application is given for the sake of exemplification and description and is not intended to limit the application to the form specifically disclosed. Many modifications and variations are possible in light of the above teachings. The implementation and description of the embodiments are intended solely for purposes of exemplification and description and are not intended to limit the scope of the application. Those skilled in the art will recognize that many modifications and variations are possible in light of the above teachings.

Claims

1. A transcranial magnetic stimulation system, characterized by, The method comprises the following steps: The head data acquisition module, the stimulation object simulation module, and the coil parameter recommendation module are connected, and the head data acquisition module is configured to acquire head data of a target stimulation object, wherein the head data comprises scalp data, skull data, and brain tissue data. The stimulation object simulation module is connected to the head data acquisition module and is configured to construct a head model of the target stimulation object according to the acquired head data. The coil parameter recommendation module is connected to the stimulation object simulation module and is configured to generate coil structure test parameters, perform simulation testing on the head model according to preset stimulation parameters and the coil structure test parameters, obtain test data, and determine a transcranial magnetic stimulation coil that is adapted to the head model according to the test data. The coil parameter recommendation module is specifically configured to perform electromagnetic field simulation testing on the head model according to the preset stimulation parameters and the coil structure test parameters, obtain electromagnetic field spatial distribution corresponding to the head model, and determine a transcranial magnetic stimulation coil that is adapted to the head model according to the electromagnetic field spatial distribution. The coil parameter recommendation module is specifically further configured to adjust the coil structure test parameters according to the electromagnetic field spatial distribution and a preset stimulation target point position, so as to obtain coil structure test parameters that are adapted to the head model, and determine a transcranial magnetic stimulation coil corresponding to the coil structure test parameters as the adapted transcranial magnetic stimulation coil. Further comprising:

2. The system of claim 1, wherein, The magnetic stimulation control circuit, the magnetic stimulation driving circuit, and the transcranial magnetic stimulation coil are connected, and the magnetic stimulation control circuit is configured to generate a magnetic stimulation control signal, wherein the magnetic stimulation control signal comprises a magnetic stimulation frequency and a magnetic stimulation intensity. The stimulation driving circuit is connected to the magnetic stimulation control circuit and the transcranial magnetic stimulation coil and is configured to generate a stimulation electric signal according to the magnetic stimulation control signal and transmit the stimulation electric signal to the transcranial magnetic stimulation coil. The transcranial magnetic stimulation coil is arranged on the head of the target stimulation object and is configured to act on the head of the target stimulation object with the received stimulation electric signal. The transcranial magnetic stimulation coil is a conical magnetic stimulation coil, and the conical magnetic stimulation coil is centrally provided with a zinc-manganese ferrite. Further comprising:

3. The system of claim 2, wherein, The stimulation driving circuit and / or the transcranial magnetic stimulation coil are provided with a temperature measuring component and a heat dissipation device, wherein 4. The system of claim 2, wherein, The temperature measuring component is configured to measure the temperature of the stimulation driving circuit and / or the transcranial magnetic stimulation coil. The heat dissipation device is configured to adjust the heat dissipation intensity according to the temperature of the stimulation driving circuit and / or the transcranial magnetic stimulation coil, so as to perform heat dissipation processing on the stimulation driving circuit and / or the transcranial magnetic stimulation coil. Further comprising: The user operation device is connected to the stimulation control circuit and is configured to receive a transcranial magnetic stimulation parameter input by a user and send the transcranial magnetic stimulation parameter to the stimulation control circuit.

5. The system of claim 2, wherein, The stimulation control circuit is further configured to generate a magnetic stimulation control signal according to the transcranial magnetic stimulation parameter. ​ ​ ​ 6. The system of claim 5, wherein, The user operation module comprises a parameter selection module and a display module, the parameter selection module comprises a stimulation parameter setting element and a stimulation mode selection element, wherein, The display module is configured to display the transcranial magnetic stimulation parameters input by the user. The stimulation parameter setting element is configured to set at least one of the magnetic stimulation frequency, the magnetic stimulation intensity, and the magnetic stimulation time. The stimulation mode selection element is configured to select at least one preset stimulation mode.

7. The system of claim 1, wherein, The head data acquisition module is configured to acquire head magnetic resonance data of a target stimulation object. The stimulation object simulation module is configured to construct a head model of the target stimulation object based on the brain tissue conductivity and dielectric constant information and the head magnetic resonance data.

8. A method for determining a transcranial magnetic stimulation coil, applied to a transcranial magnetic stimulation system, characterized in that, The transcranial magnetic stimulation system comprises a head data acquisition module, a stimulation object simulation module connected to the head data acquisition module, and a coil parameter recommendation module connected to the stimulation object simulation module, and the determination method of the transcranial magnetic stimulation coil comprises: The head data acquisition module is configured to acquire head data of a target stimulation object, wherein the head data comprises scalp data, skull data, and brain tissue data; The stimulation object simulation module is configured to construct a head model of the target stimulation object based on the acquired head data; The coil parameter recommendation module is configured to generate coil structure test parameters, perform simulation testing on the head model based on preset stimulation parameters and the coil structure test parameters, obtain test data, and determine a transcranial magnetic stimulation coil adapted to the head model based on the test data; The coil parameter recommendation module is configured to perform electromagnetic field simulation testing on the head model based on preset stimulation parameters and the coil structure test parameters, obtain an electromagnetic field spatial distribution corresponding to the head model, and determine a transcranial magnetic stimulation coil adapted to the head model based on the electromagnetic field spatial distribution; The coil parameter recommendation module is configured to adjust the coil structure test parameters based on the electromagnetic field spatial distribution and a preset stimulation target point position, to obtain coil structure test parameters adapted to the head model, and determine a transcranial magnetic stimulation coil corresponding to the coil structure test parameters as the adapted transcranial magnetic stimulation coil.

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