A blood adsorption device for removing bilirubin

Abstract

The invention relates to the technical field of blood purification, and discloses a blood adsorption device for removing bilirubin, comprising an upper end hemodialyzer and a lower end hemodialyzer connected to the upper end hemodialyzer through a connecting sleeve, wherein the liquid outlet of the upper end hemodialyzer is connected to a bilirubin adsorber through an adsorption circulation tube; by integrating the upper end hemodialyzer, the lower end hemodialyzer and the bilirubin adsorber together, while removing bilirubin, the blood is dialyzed and purified, thereby further reducing the burden on the kidneys; and only one puncture is required to simultaneously remove bilirubin and dialyze the blood, thereby reducing the pain of the patient; in addition, a mechanism for monitoring and controlling the reflux thereof is added during the adsorption and dialysis process, so that the concentration of bilirubin and other substances in the blood can be automatically monitored, and the blood can automatically reflux or pass according to the monitoring data, thereby greatly improving the intelligence and adsorption effect of the device.

Description

Technical Field

[0001] The invention relates to the technical field of blood purification, in particular to a blood adsorption device for removing bilirubin. Background Art

[0002] In recent years, some progress has been made in the treatment of hyperbilirubinemia with blood / plasma perfusion. By directly adsorbing and removing bilirubin and pathogenic cytokines from the blood, their concentration can be reduced, which not only weakens their own activity, but also inhibits the release of other harmful factors. Most of the adsorbents currently used are composed of two parts: a carrier and an adsorption ligand. The carrier mainly includes microspheres, hollow fiber membranes, and porous sheets. Common microsphere carriers include polystyrene-divinylbenzene, polymethyl methacrylate adsorption resins, etc., and fibers include polystyrene, polyvinylidene fluoride, etc. The adsorption ligands mainly include amines, polypeptides, and proteins; among them, the amine adsorption ligands mainly include polyethyleneimine, hexamethylenediamine, ethylenediamine, diethylaminoethyl, diethylenetriamine, etc. Amine ligands are mainly adsorbed through the positive charge of amines and the negative charge of phosphate groups of bilirubin.

[0003] In the prior art, bilirubin is adsorbed mainly by passing it into a bilirubin adsorption purifier to remove it. However, during the removal process, the blood cannot be dialyzed and purified, which puts a heavy burden on the liver. In addition, during the removal and purification process, it cannot be automatically monitored and refluxed, and manual work is required, which is time-consuming and labor-intensive. Summary of the invention

[0004] 1. Technical issues to be resolved

[0005] In view of the deficiencies in the prior art, the present invention provides a blood adsorption device for removing bilirubin, which has the advantages of performing dialyzing while removing and automatically monitoring and returning blood, thereby solving the problem that during the removal process, the blood cannot be dialyzed and purified, resulting in a greater burden on the kidneys. In addition, during the removal and purification process, it cannot be automatically monitored and returned, requiring manual work that is time-consuming and labor-intensive.

[0006] (II) Technical solution

[0007] To achieve the above object, the present invention provides the following technical solution: a blood adsorption device for removing bilirubin, comprising an upper end hemodialyzer and a lower end hemodialyzer connected to the upper end hemodialyzer via a connecting sleeve, the liquid outlet end of the upper end hemodialyzer is connected to a bilirubin adsorber via an adsorption circulation tube, and a blood pump 2 is provided on the adsorption circulation tube;

[0008] An upper end monitoring reflux assembly is installed on the outer side wall of the connecting sleeve, and the upper end monitoring reflux assembly includes an upper end monitoring member connected to the connecting sleeve, and the liquid outlet of the upper end monitoring member is connected to the liquid inlet of the bilirubin adsorber through an upper end reflux pipe, and a blood pump three is provided on the upper end reflux pipe;

[0009] The liquid outlet end of the lower end hemodialyzer is provided with a lower end monitoring reflux assembly, and the lower end monitoring reflux assembly includes a lower end monitoring component connected to the lower end hemodialyzer, and the two liquid outlet ends of the lower end monitoring component are respectively provided with a dialysis outlet tube and a lower end reflux tube, and the lower end reflux tube is provided with a blood pump four.

[0010] Preferably, the liquid inlet end of the upper hemodialyzer is provided with a dialysis inlet tube, and a blood pump is provided on the dialysis inlet tube.

[0011] By adopting the above scheme, the blood pump drives the blood from the dialysis inlet tube into the upper end hemodialyzer for blood purification.

[0012] Preferably, the blood pump one, the blood pump two, the blood pump three and the blood pump four are all peristaltic pumps.

[0013] By adopting the above solution, the peristaltic pump has the advantages of no pollution, high precision, good sealing and simple maintenance.

[0014] Preferably, the bilirubin adsorber comprises an adsorber shell and a separation membrane, and the separation membrane is provided inside the adsorber shell.

[0015] By adopting the above scheme, the separation membrane is coated with an adsorbent, and bilirubin can be adsorbed.

[0016] Preferably, the upper end monitoring component includes a detection tube 1, one end of which is fixedly connected to a valve body, a detector 1 is installed on the outer wall of the detection tube 1, a detection electrode 1 is provided inside the detection tube 1, one end of the detection electrode 1 extends to the interior of the connecting sleeve, and an upper end control valve is provided inside the valve body.

[0017] By adopting the above scheme, after the blood is purified by the upper hemodialyzer and the bilirubin adsorber, it passes through the connecting sleeve so that the detection electrode 1 in the connecting sleeve monitors the blood. If the monitored bilirubin value is higher than the set value, the upper control valve and the blood pump 3 are opened, so that the blood, under the action of the blood pump 3, flows back to the bilirubin adsorber through the upper reflux pipe to purify the bilirubin again. When the monitored bilirubin value is lower than the set value, the upper control valve and the blood pump 3 are closed so that the blood can enter the lower hemodialyzer for secondary purification.

[0018] Preferably, the upper control valve is a one-way solenoid valve.

[0019] By adopting the above solution, the one-way solenoid valve can prevent blood reflux and improve the accuracy of blood circulation.

[0020] Preferably, the lower end monitoring device includes a detection tube 2, a detector 2 is provided on the outer wall of the detection tube 2, a detection electrode 2 is provided inside the detection tube 2, and a three-way valve is provided at the liquid outlet end of the detection tube 2, and the two liquid outlet ends of the three-way valve are respectively connected to the dialysis outlet tube and the lower end reflux tube.

[0021] By adopting the above scheme, when the blood enters the lower end hemodialyzer, the lower end hemodialyzer performs secondary purification on the blood to improve the purification effect of the blood. When the blood passes through the lower end monitoring device, the detection electrode 2 monitors the blood. When the concentration of other substances in the blood is high, the detector 2 controls the three-way valve to open the lower end return tube and close the dialyzer outlet tube at the same time to perform secondary purification again. When the concentration of other substances reaches the standard, the detector 2 controls the three-way valve to close the lower end return tube and open the dialyzer outlet tube at the same time to allow the blood to flow back to the patient's body.

[0022] (III) Beneficial effects

[0023] Compared with the prior art, the present invention provides a blood adsorption device for removing bilirubin, which has the following beneficial effects:

[0024] The blood adsorption device for removing bilirubin integrates an upper hemodialyzer, a lower hemodialyzer and a bilirubin adsorber, and while removing bilirubin, it also performs dialyzing and purification of the blood, further reducing the burden on the kidneys. Only one puncture is required to simultaneously remove bilirubin and dialyze the blood, reducing the pain of the patient. In addition, a mechanism for monitoring and controlling the reflux is added during the adsorption and dialysis process, so that the concentration of bilirubin and other substances in the blood can be automatically monitored, and automatically refluxed or passed according to the monitoring data, greatly improving the intelligence and adsorption effect of the device. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 It is a structural schematic diagram of the present invention;

[0026] Figure 2 It is a schematic diagram of the structure of the upper and lower end monitoring reflux components and the dialysis equipment in the present invention;

[0027] Figure 3 It is a schematic diagram of the structure of the upper end reflux in the present invention;

[0028] Figure 4 It is a structural schematic diagram of the lower end reflux in the present invention;

[0029] Figure 5 It is a structural schematic diagram of the bilirubin adsorber in the present invention;

[0030] Figure 6 It is a structural schematic diagram of the upper end monitoring reflux component in the present invention;

[0031] Figure 7 It is a schematic diagram of the structure of the lower end monitoring reflux component in the present invention.

[0032] In the figure: 10, upper end hemodialyzer; 11, dialysis inlet tube; 12, blood pump 1;

[0033] 20. Connecting sleeve;

[0034] 30. Lower end hemodialyzer; 31. Dialysis outlet tube;

[0035] 40. Bilirubin adsorber; 401. adsorber housing; 402. separation membrane; 41. adsorption circulation tube; 42. blood pump 2;

[0036] 50. Upper end monitoring reflux assembly; 51. Upper end monitoring component; 511. Detection tube 1; 512. Valve body; 513. Detector 1; 514. Detection electrode 1; 515. Upper end control valve; 52. Upper end reflux tube; 53. Blood pump 3;

[0037] 60. Lower end monitoring reflux assembly; 61. Lower end monitoring component; 611. Detection tube 2; 612. Detector 2; 613. Detection electrode 2; 614. Three-way valve; 62. Lower end reflux tube; 63. Blood pump 4. DETAILED DESCRIPTION

[0038] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention. Example

[0039] A blood adsorption device for removing bilirubin, comprising an upper hemodialyzer 10 and a lower hemodialyzer 30 connected to the upper hemodialyzer 10 via a connecting sleeve 20, the liquid inlet end of the upper hemodialyzer 10 is provided with a dialysis inlet tube 11, the dialysis inlet tube 11 is provided with a blood pump 12, the liquid outlet end of the upper hemodialyzer 10 is connected with a bilirubin adsorber 40 via an adsorption circulation tube 41, the bilirubin adsorber 40 comprises an adsorber housing 401 and a separation membrane 402, the separation membrane 402 is provided inside the adsorber housing 401, and a blood pump 2 42 is provided on the adsorption circulation tube 41;

[0040] An upper end monitoring reflux assembly 50 is installed on the outer side wall of the connecting sleeve 20. The upper end monitoring reflux assembly 50 includes an upper end monitoring member 51 connected to the connecting sleeve 20. The upper end monitoring member 51 includes a detection tube 1 511. One end of the detection tube 1 511 is fixedly connected to a valve body 512. A detector 1 513 is installed on the outer side wall of the detection tube 1 511. A detection electrode 1 514 is provided inside the detection tube 1 511. One end of the detection electrode 1 514 extends to the inside of the connecting sleeve 20. An upper end control valve 515 is provided inside the valve body 512. The upper end control valve 515 is a one-way solenoid valve. The liquid outlet end of the upper end monitoring member 51 is connected to the liquid inlet end of the bilirubin adsorber 40 through the upper end reflux tube 52. A blood pump 3 53 is provided on the upper end reflux tube 52.

[0041] The liquid outlet of the lower end hemodialyzer 30 is provided with a lower end monitoring reflux assembly 60, and the lower end monitoring reflux assembly 60 includes a lower end monitoring part 61 connected to the lower end hemodialyzer 30, and the lower end monitoring part 61 includes a detection tube 2 611, and the outer wall of the detection tube 2 611 is provided with a detector 2 612, and the interior of the detection tube 2 611 is provided with a detection electrode 2 613, and the liquid outlet of the detection tube 2 611 is provided with a three-way valve 614, and the two liquid outlet ends of the three-way valve 614 are respectively connected to the dialysis outlet tube 31 and the lower end reflux tube 62, and the two liquid outlet ends of the lower end monitoring part 61 are respectively provided with the dialysis outlet tube 31 and the lower end reflux tube 62, and the lower end reflux tube 62 is provided with a blood pump 4 63, and the blood pump 1 12, blood pump 2 42, blood pump 3 53 and blood pump 4 63 are all peristaltic pumps.

[0042] See also Figure 1-5During adsorption, the dialysis inlet tube 11 and the dialysis outlet tube 31 are connected to the blood vessels of the human body through the puncture needle respectively. After the connection is completed, the blood pump 12 is started, so that the blood pump 12 drives the blood from the dialysis inlet tube 11 into the upper end hemodialyzer 10 for blood purification. After the blood is purified in the upper end hemodialyzer 10, it enters the bilirubin adsorber 40, so that the adsorbent coated on the separation membrane 402 adsorbs bilirubin. After the blood is purified by the upper end hemodialyzer 10 and the bilirubin adsorber 40, it passes through the connecting sleeve 20, so that the detection electrode 514 in the connecting sleeve 20 monitors the blood. If the monitored bilirubin value is higher than the set value, the upper end control valve 515 and the blood pump three 53 are opened, so that the blood, under the action of the blood pump three 53, flows back to the bile duct through the upper end reflux pipe 52. The bilirubin is purified again in the hemodialyzer 40. When the monitored bilirubin value is lower than the set value, the upper control valve 515 and the blood pump 3 53 are closed to allow the blood to enter the lower hemodialyzer 30 for secondary purification. When the blood enters the lower hemodialyzer 30, the lower hemodialyzer 30 performs secondary purification on the blood to improve the purification effect of the blood. When the blood passes through the lower monitoring component 61, the detection electrode 2 613 monitors the blood. When the concentration of other substances in the blood is high, the detector 2 612 controls the three-way valve 614 to open the lower return pipe 62 and close the dialyzer outlet pipe 31 at the same time to perform secondary purification again. When the concentration of other substances reaches the standard, the detector 2 612 controls the three-way valve 614 to close the lower return pipe 62 and open the dialyzer outlet pipe 31 at the same time to allow the blood to flow back to the patient's body.

[0043] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A blood adsorption device for removing bilirubin, characterized in that: It comprises an upper hemodialyzer (10) and a lower hemodialyzer (30) connected to the upper hemodialyzer (10) via a connecting sleeve (20), wherein the liquid outlet of the upper hemodialyzer (10) is connected to a bilirubin adsorber (40) via an adsorption circulation tube (41), and a blood pump 2 (42) is provided on the adsorption circulation tube (41); An upper end monitoring reflux assembly (50) is installed on the outer side wall of the connecting sleeve (20), and the upper end monitoring reflux assembly (50) comprises an upper end monitoring component (51) connected to the connecting sleeve (20), and the liquid outlet end of the upper end monitoring component (51) is connected to the liquid inlet end of the bilirubin adsorber (40) through an upper end reflux pipe (52), and a blood pump three (53) is provided on the upper end reflux pipe (52); The liquid outlet of the lower end hemodialyzer (30) is provided with a lower end monitoring reflux assembly (60), the lower end monitoring reflux assembly (60) comprises a lower end monitoring component (61) connected to the lower end hemodialyzer (30), two liquid outlet ends of the lower end monitoring component (61) are respectively provided with a dialysis outlet tube (31) and a lower end reflux tube (62), and the lower end reflux tube (62) is provided with a blood pump four (63); After the blood is purified in the upper hemodialyzer (10), it enters the bilirubin adsorber (40). After the blood is purified by the upper hemodialyzer (10) and the bilirubin adsorber (40), it passes through the connecting sleeve (20) and the upper monitoring component (51) to monitor the blood. If the monitored bilirubin value is higher than the set value, the blood flows back to the bilirubin adsorber (40) through the upper return pipe (52) to purify the bilirubin again. When the monitored bilirubin value is lower than the set value, the blood can enter the lower hemodialyzer (30) for secondary purification.

2. A blood adsorption device for removing bilirubin according to claim 1, characterized in that: The liquid inlet end of the upper hemodialyzer (10) is provided with a dialysis inlet tube (11), and a blood pump (12) is provided on the dialysis inlet tube (11).

3. A blood adsorption device for removing bilirubin according to claim 2, characterized in that: The blood pump one (12), the blood pump two (42), the blood pump three (53) and the blood pump four (63) are all peristaltic pumps.

4. A blood adsorption device for removing bilirubin according to claim 1, characterized in that: The bilirubin adsorber (40) comprises an adsorber housing (401) and a separation membrane (402), and the separation membrane (402) is arranged inside the adsorber housing (401).

5. A blood adsorption device for removing bilirubin according to claim 1, characterized in that: The upper end monitoring component (51) comprises a detection tube (511), one end of which is fixedly connected to a valve body (512), a detector (513) is installed on the outer wall of the detection tube (511), a detection electrode (514) is provided inside the detection tube (511), one end of which extends to the inside of the connecting sleeve (20), and an upper end control valve (515) is provided inside the valve body (512).

6. A blood adsorption device for removing bilirubin according to claim 5, characterized in that: The upper control valve (515) is a one-way solenoid valve.

7. A blood adsorption device for removing bilirubin according to claim 1, characterized in that: The lower end monitoring component (61) comprises a second detection tube (611), the outer wall of the second detection tube (611) is provided with a second detector (612), the interior of the second detection tube (611) is provided with a second detection electrode (613), and the liquid outlet end of the second detection tube (611) is provided with a three-way valve (614), and the two liquid outlet ends of the three-way valve (614) are respectively connected to the dialysis outlet tube (31) and the lower end return tube (62).

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