Bone marrow cell morphology analysis system

By designing an automated bone marrow cell morphology analysis system, the automatic delivery and detection of slides were achieved, solving the problems of low efficiency and insufficient accuracy in existing technologies, and improving detection efficiency and accuracy.

CN115651823BActive Publication Date: 2025-12-02HUNAN PINXIN BIOLOGICAL ENG CO LTD
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Patent Information

Application Number
CN202211179943.6
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-09-27
Publication Date
2025-12-02
Estimated Expiration
2042-09-27

AI Technical Summary

Technical Problem

Current bone marrow cell morphology testing methods are inefficient, manual testing cannot meet the demand, and it is easy to lead to inaccurate test results.

Method used

A bone marrow cell morphology analysis system was designed, including a base, a feeding module, and a detection module. The system achieves automatic slide feeding, microscopic detection, and scanner information acquisition through a slide feeding mechanism, thus realizing automated operation.

Benefits of technology

It improves testing efficiency, ensures the accuracy of test results, and reduces the fatigue and errors of testing personnel.

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Abstract

The bone marrow cell morphology analysis system provided by this invention includes a base, a feeding module mounted on the base, and a detection module mounted on the base to one side of the feeding module. The feeding module includes a slide holder and a slide conveying mechanism, and the detection module includes a microscope and a slide placement platform. The slide conveying mechanism can automatically transport slides from the slide holder to the slide placement platform located below the microscope. After the sample on the slide is detected by the microscope, the slide conveying mechanism automatically returns the slide to the slide holder. The entire process can achieve fully automated operation, which not only greatly improves the efficiency of sample detection, but also helps to ensure the accuracy of each test result because it uses mechanical operation.
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Description

Technical Field

[0001] This invention relates to the field of medical testing, and in particular to a bone marrow cell morphology analysis system. Background Technology

[0002] Bone marrow cell morphology microscopy is a key diagnostic tool in hematology, commonly used to diagnose various conditions, including leukemia, multiple myeloma, lymphoma, anemia, and pancytopenia. According to the World Health Organization's "Guidelines for the Diagnosis of Malignant Tumors of the Bone Marrow," a detailed and precise manual microscopic examination is required for diagnosis. Normal bone marrow contains differentiated cells at all stages of development, from early progenitor stem cells to functionally mature cells, including hematopoietic stem cells, which are the precursors to most blood cells, as well as mesenchymal stem cells and endothelial stem cells, considered the gatekeeper cells of the bone marrow. The morphological characteristics of these cells depend on their inherent biological properties and are also influenced by the smear, staining, and image acquisition processes.

[0003] Quality control of bone marrow cell smears and the acquisition and analysis of image information are crucial, directly determining the accuracy of subsequent analysis results. However, with the increasing volume of testing, manual testing methods are no longer efficient enough to meet the demand. Furthermore, the heavy workload can lead to physical and mental fatigue among testing personnel, potentially resulting in inaccurate test results. Summary of the Invention

[0004] In view of the above-mentioned problems in the existing technology, the bone marrow cell morphology analysis system provided by the present invention can effectively solve the problems existing in the background technology.

[0005] To achieve the above-mentioned objectives, the technical solution adopted by the present invention is as follows:

[0006] A bone marrow cell morphology analysis system includes a base, a feeding module mounted on the base, and a detection module mounted on one side of the base of the feeding module.

[0007] The feeding module includes a slide holder and a slide conveying mechanism. The slide conveying mechanism is used to convey slides from the slide holder to the detection module, and can convey several slides at a time.

[0008] And the slide conveying mechanism is used to convey the slides located on the detection module and after detection to another slide holder in the feeding module;

[0009] The detection module includes a microscope, a scanner, and a slide placement platform. The slide delivery mechanism delivers the slide to the slide placement platform, which then drives the slide above it to below the lens of the microscope. The microscope is used to detect the sample on the slide, and the scanner is used to scan the QR code information on the slide.

[0010] In one embodiment, the slide conveying mechanism includes a conveying bracket mounted on the base. A conveying base plate is mounted on the conveying bracket, and a first slide rail is mounted on the conveying base plate. A first slider is mounted on the first slide rail, and a transmission plate is mounted on the first slider. A first motor is mounted on the conveying base plate at one end of the first slide rail, and a first toothed pulley is rotatably mounted on the conveying base plate at the other end of the first slide rail. A second toothed pulley is mounted on the main shaft of the first motor, and a first toothed belt is fitted onto both the first and second toothed pulleys.

[0011] The transmission plate is provided with a first connecting block, and the first connecting block is provided with a first toothed block, which meshes with the first toothed belt.

[0012] The transmission plate is provided with a connecting rod, and the connecting rod is provided with a driving plate for driving the glass slide. The driving plate is located below the glass slide holder, and the detection module is located on the base at one end of the first slide rail.

[0013] In one embodiment, the conveying base plate is provided with a drive plate lifting hole, and the first slide rails are symmetrically provided on both sides of the drive plate lifting hole. A motor base plate is provided below the transmission plate, and a second motor is provided on the motor base plate. The lower end of the connecting rod passes through the transmission plate and the drive plate lifting hole in sequence and is connected to the motor base plate. The main shaft of the second motor passes through the transmission plate and is threadedly connected to the transmission plate.

[0014] In one embodiment, the slide holder includes a column plate and two base plates. The two base plates are arranged in a front-to-back orientation above the conveying bracket, and the base plates are parallel to the first slide rail. Several column plates are spaced apart on each of the two base plates. At the same time, a space for accommodating slides is formed between four adjacent column plates on the two base plates. The column plates located at the ends of the base plates have an "L" shaped cross-section, and the column plates located in the middle of the base plates have a "┻" or "┲" shaped cross-section.

[0015] In one embodiment, three column plates are symmetrically arranged on each of the two base plates. Glass slides are stacked between four adjacent column plates located at the left ends of the two base plates. Several glass slides to be tested are placed on the glass slides. Two vertically movable glass slide stop pins are respectively provided on the inner sides of the two column plates located in the middle of the base plates, and the two glass slide stop pins are respectively located below the glass slides to be tested.

[0016] The lower end of the inner sidewall of the column plate is provided with a first notch, and a channel for sliding the glass slide is formed between the lower end of the inner sidewall of the column plate and the upper end surface of the base plate.

[0017] The upper surface of the drive plate is provided with a glass slide drive block, and the lower surface of the glass slide is provided with a drive hole. The glass slide drive block can be inserted into the drive hole to drive the glass slide loaded with the glass slide to be tested to move to the left until it falls into the channel formed between the column plate and the base plate.

[0018] In one embodiment, a glass slide is also placed between the four adjacent pillar plates on the right side of the two base plates. The glass slide between the four adjacent pillar plates on the right side of the two base plates is used to place the glass slide that has been detected by the detection module.

[0019] In one embodiment, two base plates are respectively provided with slide plate limiting block seats, which are located between two column plates on the right end of the base plates. Each slide plate limiting block seat is provided with a slide plate limiting block that can be deflected back and forth relative to the base plate and automatically return to its original position. The inner sidewall of the slide plate limiting block is gradually inclined towards the inner side of the base plate from top to bottom. The distance between the tops of the two slide plate limiting blocks is less than the length of the slide plate in the front-back direction, and the distance between the bottoms is greater than the length of the slide plate in the front-back direction. The slide plates used to place the slides detected by the detection module are stacked on the two slide plate limiting blocks.

[0020] In one embodiment, a microscope support is provided on a base located on the right side of the base plate, the microscope and scanner are provided on the microscope support, the slide placement platform is provided below the microscope support, and the scanner is located at the left end of the microscope support.

[0021] In one embodiment, the slide placement platform includes a platform base, a first moving plate, a second moving plate, and a slide fixing plate.

[0022] The platform base is mounted on the base, and the platform base is provided with a second slide rail in the front-to-back direction, and a second slider is provided on the second slide rail.

[0023] The first motion plate is mounted on the second slider, and a first linear motor for driving the first motion plate is disposed between the platform base and the first motion plate.

[0024] The first motion plate is provided with a third slide rail in the left-right direction, and a third slider is provided on the third slide rail.

[0025] The second moving plate is mounted on the third slider, and a second linear motor for driving the second moving plate is disposed between the second moving plate and the first moving plate.

[0026] The glass slide fixing plate is mounted on the second moving plate.

[0027] In one embodiment, a second notch is provided on the side of the slide plate fixing plate near the slide holder, and each edge of the second notch is provided with a recessed step. The slide plate fixing plate is also provided with a slide plate fixing spring, one end of which is connected to the upper surface of the slide plate fixing plate, and the other end is located above the step on the slide plate fixing plate. The slide plate driving block drives the slide plate through the channel formed between the column plate and the base plate until it reaches the step on the slide plate fixing plate and is fixed by the slide plate fixing spring.

[0028] Compared with existing technologies, the bone marrow cell morphology analysis system provided by this invention includes a base, a feeding module on the base, and a detection module on the base located on one side of the feeding module. The feeding module includes a slide holder and a slide conveying mechanism, and the detection module includes a microscope and a slide placement platform. The slide conveying mechanism can automatically transport slides from the slide holder to the slide placement platform located below the microscope. After the sample on the slide is detected by the microscope, the slide conveying mechanism automatically returns the slide to the slide holder. The entire process can achieve fully automated operation, which not only greatly improves the efficiency of sample detection, but also helps to ensure the accuracy of each test result because it uses mechanical operation. Attached Figure Description

[0029] Figure 1 This is a schematic diagram of the first three-dimensional structure of the present invention;

[0030] Figure 2 This is a schematic diagram of the second partial three-dimensional structure of the present invention;

[0031] Figure 3 This is a schematic diagram of the third partial three-dimensional structure of the present invention;

[0032] Figure 4 This is a bottom view of the glass slide structure of the present invention;

[0033] Figure 5 This is a schematic diagram of the fourth partial three-dimensional structure of the present invention;

[0034] Figure 6 This is a schematic diagram of the fifth partial three-dimensional structure of the present invention;

[0035] Figure 7 This is a three-dimensional structural diagram of the glass slide plate limiting block and the glass slide plate limiting block rotating shaft of the present invention.

[0036] Figure 8 This is a three-dimensional schematic diagram of the glass slide placement platform in this invention. Detailed Implementation

[0037] In the description of this invention, it should be understood that the terms "center", "longitudinal", "lateral", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "axial", "radial", etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this invention and simplifying the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this invention.

[0038] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this invention, "a plurality of" means two or more, unless otherwise explicitly specified.

[0039] In this invention, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0040] In this invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can mean that the first feature is in direct contact with the second feature, or that the first feature is in indirect contact with the second feature through an intermediate medium. Furthermore, "above," "over," and "on top" of the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply that the first feature is at a lower horizontal level than the second feature.

[0041] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0042] like Figure 1-8 As shown,

[0043] The bone marrow cell morphology analysis system includes a base 1, a feeding module 100 mounted on the base 1, and a detection module 200 mounted on the right side of the base of the feeding module 100.

[0044] The feeding module 100 includes a slide holder 300 and a slide conveying mechanism 400. The slide conveying mechanism 400 is used to convey the slides 2 on the slide holder 300 to the detection module 200, and the slide conveying mechanism 400 can convey several slides 2 at a time.

[0045] Additionally, the slide conveying mechanism 400 is used to convey the slide 2 located on the detection module 200 and after detection to another slide holder 300 in the feeding module 100;

[0046] The detection module 200 includes a microscope 3, a scanner 4, and a slide placement platform 500. The slide conveying mechanism 400 conveys the slide 2 to the slide placement platform 500, which then drives the slide 2 above it to below the lens of the microscope 3. The microscope 3 is used to detect the sample on the slide 2. The scanner 4 is used to scan the QR code information on the slide 2. This QR code information contains the identity information of the patient corresponding to the test sample, to ensure that the test information is completely matched with the patient, and also to facilitate the presentation and printing of subsequent test results.

[0047] In this embodiment, the slide conveying mechanism 400 includes a conveying bracket 5, which is mounted on a base 1. A conveying base plate 6 is mounted on the conveying bracket 5, a first slide rail 7 is mounted on the conveying base plate 6, a first slider 8 is mounted on the first slide rail 7, and a transmission plate 9 is mounted on the first slider 8. A first motor 10 is mounted on the conveying base plate 6 at one end of the first slide rail 7, and a first toothed pulley 11 is rotatably mounted on the conveying base plate 6 at the other end of the first slide rail 7 via a rotating shaft. A second toothed pulley 12 is mounted on the main shaft of the first motor 10, and a first toothed belt 13 is fitted onto the first toothed pulley 11 and the second toothed pulley 12.

[0048] A first connecting block 14 is provided on the transmission plate 9, and a first toothed block 15 is provided on the first connecting block 14. The first connecting block 14 and the first toothed block 15 are fitted together to clamp the first toothed belt 13 between the first connecting block 14 and the first toothed block 15. At the same time, the first toothed block 15 and the first toothed belt 13 mesh with each other through the teeth on their own.

[0049] A connecting rod 16 is provided on the transmission plate 9, and a driving plate 17 for driving the glass slide 2 is provided on the connecting rod 16. The driving plate 17 is located below the glass slide holder 300, and the detection module 200 is located on the base 1 at the right end of the first slide rail 7.

[0050] The above structural design shows that the first motor 10 drives the drive plate 17 to move left and right along the first slide rail 7 through the first toothed belt 13, the first toothed block 15, the first connecting block 14, the transmission plate 9 and the connecting rod 16, thereby driving the glass slide on the glass slide holder 300 to the detection module 200.

[0051] Furthermore, the conveying base plate 6 is provided with a drive plate lifting hole, and first slide rails 7 are symmetrically provided on both sides of the drive plate lifting hole. By providing two first slide rails 7, the movement of the transmission plate 9 is made more stable, and the movement of the corresponding drive plate 17 is more stable and precise, thereby realizing the precise conveying operation of the glass slide 2. A motor base plate 19 is provided below the transmission plate 9, and a second motor 20 is provided on the motor base plate 19. The lower end of the connecting rod 16 passes through the transmission plate 9 and the drive plate lifting hole in sequence and is connected to the motor base plate 19. The main shaft of the second motor 20 passes through the transmission plate 9 upward and is threadedly connected to the transmission plate 9.

[0052] Preferably, a first bushing 44 is provided at the center point of the transmission plate 9, and two second bushings 45 are symmetrically arranged on the transmission plate 9 relative to its center point. Connecting rods 16 are slidably provided inside the two second bushings 45. The main shaft of the second motor 20 is threadedly connected to the first bushing 44. By symmetrically arranging the two connecting rods 16, the drive plate 17 is driven to move up and down. Therefore, the up and down movement of the drive plate 17 is more stable, thereby realizing the smooth up and down movement of the drive glass slide 2.

[0053] As can be seen from the above structural design, when the main shaft of the second motor 20 rotates, because the transmission plate 9 is fixed on the conveying base plate 6, and the conveying base plate 6 is fixed on the base 1 through the conveying bracket 5, the second motor 20, the motor base plate 19, the connecting rod 16 and the drive plate 17 can move up or down together.

[0054] In this embodiment, the slide holder 300 includes a column plate 21 and two base plates 22. The two base plates 22 are arranged above the conveying bracket 5 in a front-to-back orientation and are parallel to each other. The base plates 22 are arranged parallel to the first slide rail 7. Several column plates 21 are arranged at intervals on the two base plates 22. At the same time, a space for accommodating the slide 2 is formed between four adjacent column plates 21 located on the two base plates 22. The cross-section of the column plate 21 located at the end of the base plate 22 is "L" shaped, and the cross-section of the column plate 21 located in the middle of the base plate 22 is "┻" or "┲" shaped.

[0055] Specifically, three upright plates 21 are symmetrically arranged on each of the two base plates 22. Several glass slides 23 are stacked between four adjacent upright plates 21 located on the left side of the two base plates 22. Each glass slide 23 holds five glass slides 2 to be tested. Two movable glass slide stop pins 24 are respectively provided on the inner sides of the two upright plates 21 located in the middle of the base plate 22, and the two glass slide stop pins 24 are located below the glass slides 2 to be tested.

[0056] The lower end of the inner sidewall of the column plate 21 is provided with a first notch 25, and a channel for sliding the glass slide is formed between the lower end of the inner sidewall of the column plate 21 and the upper end face of the base plate 22.

[0057] The upper surface of the drive plate 17 is provided with a slide plate drive block 26, and the lower surface of the slide plate 23 is provided with a drive hole 27, into which the slide plate drive block 26 can be inserted.

[0058] Specifically, the column plate 21 is provided with stop pin holes 46, and the slide stop pin 24 is slidably embedded in the stop pin hole 46. The height of the stop pin hole 46 is greater than the height of the slide stop pin 24. The inner side of the slide stop pin 24 protrudes inward to extend beyond the inner wall of the column plate 21 and is located below the slide 2.

[0059] Stop pin adjusting blocks 47 are respectively provided on the column plate 21 above the stop pin hole 46. Stop pin adjusting screws 48 are screwed onto the stop pin adjusting blocks 47. The threaded end of the stop pin adjusting screws 48 passes through the stop pin adjusting blocks 47 and is screwed onto the glass slide stop pin 24. Therefore, by rotating the stop pin adjusting screws 48, the glass slide stop pin 24 can be driven to move up and down in the stop pin hole 46, thereby adjusting the height of the right end of the glass slide 2.

[0060] Therefore, firstly, the second motor 20 drives the slide plate driving block 26 downward through the driving plate 17. Then, the first motor 10 drives the slide plate driving block 26 to the bottom of the driving hole 27 of the slide plate 23 through the driving plate 17. Then, the second motor drives the slide plate driving block 26 upward to insert into the driving hole 27. Then, the first motor 10 drives the slide plate 23 loaded with the slide 2 to be tested to move to the left. After moving a certain distance, the right end of the slide plate 23 will fall off the two slide stop pins 24 until the entire slide plate 23 falls into the channel formed between the column plate 21 and the base plate 22. Then, the first motor 10 continues to drive the slide plate 23 loaded with the slide 2 to be tested to move to the right until the slide plate 23 is transported to the slide placement platform 500.

[0061] In this embodiment, a glass slide plate 23 is also placed between the four adjacent column plates 21 on the right side of the two base plates 22. The glass slide plate 23 between the four adjacent column plates 21 on the right side of the two base plates 22 is used to place the glass slide after it has been detected by the detection module 200.

[0062] Furthermore, each of the two base plates 22 is provided with a slide plate limiting block seat 28, which is located between the two column plates 21 on the right end of the base plate 22. Each slide plate limiting block seat 28 is provided with a slide plate limiting block 29 that can be deflected back and forth relative to the base plate 22 and can automatically return to its original position.

[0063] Preferably, a slide plate limiting block pivot 49 is embedded in the slide plate limiting block seat 28, with both ends of the pivot 49 penetrating the side wall of the slide plate limiting block seat 28. A return spring is provided between the pivot 49 and the slide plate limiting block seat 28, and the return spring is fitted onto the pivot 49. Slide plate limiting blocks 29 are respectively provided at both ends of the pivot 49, and the slide plates 23 that have undergone testing are stacked on the four slide plate limiting blocks 29.

[0064] Furthermore, the inner sidewall of the slide plate limiting block 29 is gradually inclined towards the inner side of the base plate 22 from top to bottom, and the distance between the tops of the two slide plate limiting blocks 29 is less than the length of the slide plate 23 in the front-back direction, while the distance between the bottoms is greater than the length of the slide plate 23 in the front-back direction.

[0065] After the slide 2 on the slide placement platform 500 has undergone inspection, the first motor 10 drives the slide plate 23 containing the slide 2 on the slide placement platform 500 to below the four slide plate limiting blocks 29 via the slide plate drive block 26. Then, the second motor 20 drives the entire slide plate 23 to move upward. Because the inner wall of the slide plate limiting block 29 is gradually inclined towards the inner side of the base plate 22 from top to bottom, it can also deflect back and forth relative to the base plate 22 and can automatically return to its original position.

[0066] Therefore, during the upward movement of the slide plate 23, the upper end of the slide plate limiting block 29 slowly deflects outward to allow the slide plate 23 to move upward until the bottom of the slide plate 23 exceeds the top of the slide plate limiting block 29. At this time, the slide plate limiting block 29 automatically deflects inward under the action of the return spring. At the same time, because the distance between the tops of the slide plate limiting blocks 29 on the front and rear sides after the return is less than the length of the slide plate 23 in the front and rear direction, after the second motor 20 drives the slide plate driving block 26 to exit from the driving hole 27 on the slide plate 23, the slide plate 23 will be placed on the four slide plate limiting blocks 29. Thus, the above action is repeated, and several slide plates 23 will be stacked between the four adjacent column plates 21 on the right side of the two base plates 22, realizing the recycling of the detected slide 2.

[0067] In this embodiment, a microscope support 30 resembling an arch is provided on the base 1 located on the right side of the base plate 22. A microscope 3 and a scanner 4 are provided on the microscope support 30. A slide placement platform 500 is provided below the microscope support 20, and the scanner 4 is located at the left end of the microscope support 30.

[0068] In this embodiment, the slide placement platform 500 includes a platform base 31, a first moving plate 32, a second moving plate 33, and a slide fixing plate 34.

[0069] The platform base 31 is mounted on the base 1. Two parallel second slide rails 35 are mounted on the platform base 31, and second sliders are mounted on the second slide rails 35.

[0070] The first motion plate 32 is mounted on the second slider, and a first linear motor for driving the first motion plate 32 is disposed between the platform base 31 and the first motion plate 32.

[0071] The first moving plate 32 is provided with two parallel third slide rails 38 along the left and right directions, and a third slider is provided on the third slide rail 38.

[0072] The second motion plate 33 is mounted on the third slider, and a second linear motor for driving the second motion plate 33 is disposed between the second motion plate 33 and the first motion plate 32.

[0073] The glass slide fixing plate 34 is mounted on the second moving plate 33;

[0074] As can be seen from the above structural design, the slide plate fixing plate 34 used to place the slide plate 23 from the slide holder 300 can move back and forth and left and right relative to the microscope 3 with the first linear motor and the second linear motor until the slide 2 on the slide plate 23 is moved to a suitable position so that the microscope 3 can detect the sample on it.

[0075] In this embodiment, a second notch is provided on the side of the slide plate fixing plate 34 near the slide holder 300. Each edge of the second notch is provided with a recessed step 42. Slide plate fixing springs 43 are also provided at the front and rear ends of the slide plate fixing plate 34. One end of the slide plate fixing spring 43 is connected to the upper surface of the slide plate fixing plate 34, and the other end is located above the steps 42 at the front and rear ends of the slide plate fixing plate 34. Therefore, the slide plate driving block 26 drives the slide plate 23 from the slide holder 300 through the channel formed between the column plate 21 and the base plate 22. The slide plate is fixed on the step 43 of the slide plate fixing plate 34 and fixed by the slide plate fixing spring 43. At the same time, since the scanner 4 is located at the left end of the microscope support 30, the scanner 4 will first scan the QR code information on each slide 2 on the slide plate 23 and transmit the information to the controller used to control the operation of the entire device. Meanwhile, the microscope 3 will also transmit the information obtained from the detection of the sample on the slide 2 to the controller. The controller will match and merge the information from the scanner 4 and the microscope 3 to form a complete sample detection report.

[0076] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0077] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these modifications and improvements all fall within the scope of protection of the present invention. Therefore, the scope of protection of this patent should be determined by the appended claims.

Claims

1. A bone marrow cell morphology analysis system, characterized in that, The system includes a base, on which a feeding module is mounted, and a detection module mounted on one side of the base of the feeding module. The feeding module includes a slide holder and a slide conveying mechanism. The slide conveying mechanism is used to convey slides from the slide holder to the detection module, and can convey several slides at a time. And the slide conveying mechanism is used to convey the slides located on the detection module and after detection to another slide holder in the feeding module; The detection module includes a microscope, a scanner, and a slide placement platform. The slide delivery mechanism delivers the slide to the slide placement platform, and the slide placement platform drives the slide located above it to below the lens of the microscope. The microscope is used to detect the sample on the slide, and the scanner is used to scan the QR code information on the slide. The slide conveying mechanism includes a conveying bracket mounted on a base. A conveying base plate is mounted on the conveying bracket, and a first slide rail is mounted on the base plate. A first slider is mounted on the first slide rail, and a transmission plate is mounted on the first slider. A first motor is mounted on the base plate at one end of the first slide rail, and a first toothed pulley is rotatably mounted on the base plate at the other end of the first slide rail. A second toothed pulley is mounted on the main shaft of the first motor, and a first toothed belt is fitted onto both the first and second toothed pulleys. The transmission plate is provided with a first connecting block, and the first connecting block is provided with a first toothed block, which meshes with the first toothed belt. The transmission plate is provided with a connecting rod, and the connecting rod is provided with a driving plate for driving the glass slide. The driving plate is located below the glass slide holder, and the detection module is located on the base at one end of the first slide rail. The conveying base plate is provided with a drive plate lifting hole, and the first slide rails are symmetrically arranged on both sides of the drive plate lifting hole. A motor base plate is provided below the transmission plate, and a second motor is provided on the motor base plate. The lower end of the connecting rod passes through the transmission plate and the drive plate lifting hole in sequence and is connected to the motor base plate. The main shaft of the second motor passes through the transmission plate and is threadedly connected to the transmission plate.

2. The bone marrow cell morphology analysis system according to claim 1, characterized in that, The slide holder includes upright plates and two base plates. The two base plates are arranged in a front-to-back orientation above the conveying bracket and are parallel to the first slide rail. Several upright plates are spaced apart on each of the two base plates. A space for accommodating slides is formed between four adjacent upright plates on the two base plates. The upright plates at the ends of the base plates have an "L" shaped cross-section, while the upright plates in the middle of the base plates have a "┻" or "┲" shaped cross-section.

3. The bone marrow cell morphology analysis system according to claim 2, characterized in that, Three column plates are symmetrically arranged on each of the two base plates. Glass slides are stacked between four adjacent column plates located at the left end of each of the two base plates. Several glass slides to be tested are placed on the glass slides. Two vertically movable glass slide stop pins are respectively provided on the inner sides of the two column plates located in the middle of the base plates, and the two glass slide stop pins are respectively located below the glass slides to be tested. The lower end of the inner sidewall of the column plate is provided with a first notch, and a channel for sliding the glass slide is formed between the lower end of the inner sidewall of the column plate and the upper end surface of the base plate. The upper surface of the drive plate is provided with a glass slide drive block, and the lower surface of the glass slide is provided with a drive hole. The glass slide drive block can be inserted into the drive hole to drive the glass slide loaded with the glass slide to be tested to move to the left until it falls into the channel formed between the column plate and the base plate.

4. The bone marrow cell morphology analysis system according to claim 3, characterized in that, Meanwhile, glass slides are also placed between the four adjacent column plates on the right side of the two base plates. The glass slides between the four adjacent column plates on the right side of the two base plates are used to place glass slides that have been detected by the detection module.

5. The bone marrow cell morphology analysis system according to claim 4, characterized in that, Each of the two base plates is provided with a slide plate limiting block seat. The slide plate limiting block seat is located between two column plates on the right end of the base plate. Each slide plate limiting block seat is provided with a slide plate limiting block that can be deflected back and forth relative to the base plate and automatically return to its original position. The inner sidewall of the slide plate limiting block is gradually inclined towards the inner side of the base plate from top to bottom. The distance between the tops of the two slide plate limiting blocks is less than the length of the slide plate in the front-back direction, and the distance between the bottoms is greater than the length of the slide plate in the front-back direction. The slide plates used to place the slides after being detected by the detection module are stacked on the two slide plate limiting blocks.

6. The bone marrow cell morphology analysis system according to claim 3, characterized in that, A microscope support is provided on the base located on the right side of the base plate. The microscope and scanner are provided on the microscope support. The slide placement platform is provided below the microscope support, and the scanner is located at the left end of the microscope support.

7. The bone marrow cell morphology analysis system according to claim 6, characterized in that, The slide placement platform includes a platform base, a first moving plate, a second moving plate, and a slide fixing plate. The platform base is mounted on the base, and the platform base is provided with a second slide rail in the front-to-back direction, and a second slider is provided on the second slide rail. The first motion plate is mounted on the second slider, and a first linear motor for driving the first motion plate is disposed between the platform base and the first motion plate. The first motion plate is provided with a third slide rail in the left-right direction, and a third slider is provided on the third slide rail. The second moving plate is mounted on the third slider, and a second linear motor for driving the second moving plate is disposed between the second moving plate and the first moving plate. The glass slide fixing plate is mounted on the second moving plate.

8. The bone marrow cell morphology analysis system according to claim 7, characterized in that, A second notch is provided on the side of the slide plate fixing plate near the slide holder. Each edge of the second notch is provided with a recessed step. The slide plate fixing plate is also provided with a slide plate fixing spring. One end of the slide plate fixing spring is connected to the upper surface of the slide plate fixing plate, and the other end is located above the step on the slide plate fixing plate. The slide plate driving block drives the slide plate through the channel formed between the column plate and the base plate until it reaches the step on the slide plate fixing plate and is fixed by the slide plate fixing spring.

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