A gel-type cleaning agent for dental braces and its preparation and application

Abstract

The present invention relates to the technical field of cleaning of orthodontic appliances, and provides a gel-type cleaning agent for dental orthodontic appliances and its preparation and application. The gel-type cleaning agent comprises a gel, a bactericide, a biological enzyme and water; the gel is one or more of cellulose gum, guar gum, xanthan gum, sodium alginate, chitosan, polyvinyl alcohol and carbomer; the bactericide is a guanidine bactericide and / or a plant bactericide; the biological enzyme is one or more of glucose oxidase, glucanase, protease, amylase, lysozyme and superoxide dismutase; wherein the mass ratio of the gel to the bactericide is 1-10:0.01-5.0, and the mass ratio of the gel to the biological enzyme is 1-10:0.01-5. The preparation method is to mix the raw materials in a certain order, and the prepared gel-type cleaning agent is applied into the orthodontic appliance when the appliance is worn, and can maintain stable and excellent bactericidal performance for a long time, and has a wide range of applications.

Description

Technical Field

[0001] The present invention relates to the technical field of cleaning of orthodontic appliances, and in particular to a gel-type cleaning agent for dental orthodontic appliances and the preparation and application thereof. Background Art

[0002] Orthodontic treatment is mainly aimed at adjusting malocclusion, that is, during the growth and development of a person, it is used to treat the uneven teeth, misaligned upper and lower dental arches, abnormal upper and lower jaw positions or sizes, and inharmonious relationships between the jaw and the face caused by various reasons. Orthodontic treatment is currently the most widely used clinical and efficient correction technology, which can improve the aesthetics of teeth while also improving chewing efficiency.

[0003] Invisible braces are thermoplastic, removable, transparent braces that appeared in the late 1990s. No archwires or brackets are used during the treatment process, and they can be removed without affecting the appearance. In order to achieve continuous tooth movement, each pair of braces needs to be worn in the patient's mouth for 1 to 2 weeks, and the wearing time is more than 20 hours a day. Studies have found that even if patients strictly follow the doctor's instructions to maintain oral and brace hygiene during orthodontic treatment, oral microorganisms will be adsorbed on the surface of the braces, forming a dental plaque biofilm on the surface of the material.

[0004] Dental plaque biofilm is a biofilm that gradually deposits on the surface of teeth, composed of food residues, shed oral cells, saliva and bacteria. Within 1 hour of wearing the braces, sediment will appear on the surface of the braces material; within 6 to 12 hours, bacteria will begin to colonize, and the flora will initially adhere mainly to the raised edges of the braces and the rougher parts of the surface. After wearing for a period of time, the braces will have microcracks, wear and stratification areas, local calcified biofilm deposition and decreased transparency. Among them, the increase in the roughness of the braces surface will increase the adhesion of bacteria to the surface of the braces to a certain extent. Within 2 weeks, different types of bacteria will be staggered and accumulated on the surface of the braces to form a mature dental plaque biofilm. The part of the braces close to the teeth or the part connected to the accessories is relatively hidden, accommodating more dental plaque biofilm.

[0005] The growth of dental plaque biofilm not only affects the appearance of braces, but is also a potential risk factor for the development of bacteria-related diseases. After 6 months of orthodontic treatment, the total number of Streptococcus mutans, Lactobacillus and Candida albicans in the mouth will increase significantly, which can easily cause periodontal disease, bad breath and dental caries. Cleaning the braces can not only reduce the entry of bacteria into the mouth, but also keep the braces beautiful, transparent and odor-free. At the same time, it also has a certain impact on the performance of the braces, which may affect the final correction effect to a certain extent.

[0006] At present, there are two main methods for cleaning braces, one is physical method and the other is chemical cleaning. Physical cleaning mainly uses a toothbrush to brush, but toothbrush brushing can only remove part of the dental plaque. It is difficult to clean the part of the braces near the tip of the teeth and the recessed parts of the accessories. In addition, the friction and wear of the toothbrush will cause the light transmittance of the braces to drop significantly, reducing the mechanical properties of the braces. Chemical cleaning mainly uses various types of cleaning agents, such as hydrogen peroxide cleaners, mouthwashes, chlorhexidine solutions, biofilm cleaning agents, etc., to soak or brush the braces, and then rinse them thoroughly with running water before wearing them. The chemical cleaning method can effectively reduce the accumulation of dental plaque, but the operation is cumbersome and the effect is short-lived. In addition, the use of strong oxidizing bactericides can easily lead to the attenuation of the mechanical properties of the braces material, affecting the accuracy of the correction; it can also increase the surface roughness of the braces, make it easier for plaque to adhere, reduce the light transmittance, and reduce the aesthetic effect. In the prior art, peroxide cleaning agents are used, such as the invention patent CN102552054B discloses a denture effervescent tablet and its preparation method and application, which uses sodium percarbonate and sodium persulfate as oxidants. However, from the research on the use of braces, frequent use of chemical cleaning agents for cleaning is cumbersome and may damage the braces.

[0007] In view of the defects of existing cleaning methods for braces, the inventor, from the perspective of oral care products, proposed a new gel-type cleaner for dental braces with rapid sterilization and tooth care functions, as well as its preparation and application. Summary of the invention

[0008] The main purpose of the present invention is to overcome the defects of existing braces cleaning agent products and provide a gel-type cleaning agent with rapid sterilization and tooth care functions and its preparation and application. The gel-type cleaning agent can be applied inside the braces and has the characteristics of fast sterilization speed, high sterilization rate, and long-lasting tooth care effect. In addition, the gel-type cleaning agent can also improve the convenience of wearing the braces.

[0009] The present invention proposes for the first time a gel-type cleaner for dental braces as described above, and provides a new cleaning method for invisible dental braces, which is completely different from the traditional soaking and brushing. The gel-type cleaner in the present invention is colorless and transparent, and can be placed on the inner surface of the dental braces by smearing or the like when the dental braces are worn. Because of its gel state, it can penetrate well into the part close to the tip of the tooth and the recess of the attachment, and can continue to maintain stable and excellent bactericidal performance during long-term wearing, avoiding the decrease of indicators such as the transparency of the dental braces due to the prolonged wearing time, affecting the bactericidal effect and appearance; further, after the dental braces are taken out, the gel-type braces cleaner can also be rinsed and removed by conventional water. By using the gel-type cleaner of the present invention during the use of the dental braces, the generation of dental plaque biofilm is avoided, and the residual cleaner can be removed by water washing after taking it out, without damaging the surface of the dental braces, and even more without destroying the mechanical properties of the dental braces. Moreover, other components in gel-type cleansers, such as tooth whitening agents and biological enzymes, can act on the tooth surface for a long time during long-term wear, and have the effects of whitening teeth, inhibiting the growth of oral bacteria, and maintaining healthy gums; in addition, gel-type cleansers can lubricate the surface of the braces and facilitate the wearing of the braces.

[0010] During the research process of the present invention, it was found that the long-term bactericidal performance of the gel cleaner is directly related to the stability of its bactericidal components in the system. The present invention uses a specific gel and controls the types and contents of the bactericide and the biological enzyme, so that the gel cleaner for the dental appliance has both excellent initial bactericidal rate and long-term bactericidal rate, and can kill Streptococcus mutans, Lactobacillus and Candida albicans within 1 minute, with a bacterial killing rate of up to 99.999%, which has a good bactericidal effect; and after 90 days, the bacterial killing rate of the gel cleaner of the present invention is still as high as 99.999%, which has a long-term bactericidal effect.

[0011] Specifically, the present invention provides a gel-type cleaning agent for a dental appliance, comprising: a gel, a bactericide, a biological enzyme and water;

[0012] The gelling agent is one or more of cellulose gum, guar gum, xanthan gum, sodium alginate, chitosan, polyvinyl alcohol and carbomer; the bactericide is a guanidine bactericide and / or a plant bactericide; the biological enzyme is one or more of glucose oxidase, dextranase, protease, amylase, lysozyme and superoxide dismutase;

[0013] In the gel-type cleaner, the mass ratio of the gel to the bactericide is 1-10:0.01-5.0, the mass ratio of the gel to the biological enzyme is 1-10:0.01-5, and the mass fraction of the gel is 1-10%.

[0014] Preferably, the mass ratio of the gelling agent to the bactericide is 1-10:0.01-4.0;

[0015] Preferably, the gelling agent is xanthan gum.

[0016] According to the gel-type cleaner for dental braces provided by the present invention, the guanidine bactericide is at least one of chlorhexidine acetate, chlorhexidine gluconate, polyhexamethylene biguanide, polyhexamethylene guanidine and polyhexamethylene guanidine salt; the plant bactericide is at least one of ginger root extract, ginger essential oil, paeonol, thymol, eucalyptol, honeysuckle extract, magnolia bark extract, catechins and grapefruit extract.

[0017] The present invention finds through comparison that when guanidine fungicides are used in combination with plant fungicides, the fungicidal range is wider, the fungicidal effect is better, and the toxicity and irritation to the human body are low.

[0018] The gel-type cleaning agent for a dental appliance provided by the present invention further comprises: a tooth whitening agent and / or fluoride;

[0019] The tooth whitening agent is one or more of sodium phytate, sodium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate and sodium ethylenediaminetetraacetate;

[0020] The fluoride is one or more of sodium monofluorophosphate, sodium fluoride and strontium fluoride.

[0021] Preferably, the mass ratio of the gel to the tooth whitening agent is 1-10:0.1-10.0, preferably 1-10:0.1-8.0;

[0022] Preferably, the mass ratio of the gelling agent to the fluoride is 1-10:0.1-10.0, preferably 1-10:0.1-5.0.

[0023] The tooth whitening agents selected by the present invention, such as sodium phytate, sodium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, sodium ethylenediaminetetraacetic acid, etc., have strong complexing power, can react with colored stains such as smoke stains and tea stains deposited on the tooth surface, generate water-soluble organic complex salts, promote the desorption of proteins and pigments on the surface of tooth enamel, reduce the formation of smoke stains, tea stains, etc. on the tooth surface, inhibit the mineralization of dental plaque, and prevent the appearance of new stains.

[0024] The present invention has found that when the fluoride of the present invention is added to the gel-type cleaner, the fluoride can act on the tooth surface for a long time, promote tooth remineralization, and have the effect of caring for teeth.

[0025] The gel-type cleaning agent for a dental appliance provided by the present invention further comprises: a flavoring agent; the flavoring agent is one or more of a breath freshener, a cooling agent and a flavor;

[0026] Preferably, the breath freshener is one or more of zinc citrate, 0-cymene-5-ol, tea extract, licorice extract and Zanthoxylum bungeana extract.

[0027] Preferably, the cooling agent is menthol and / or borneol.

[0028] Preferably, the flavor is at least one of floral, fruity, tea, minty, and marine flavors.

[0029] More preferably, the breath freshener accounts for ≤0.5% by mass;

[0030] More preferably, the mass proportion of the cooling agent is ≤0.5%;

[0031] More preferably, the mass proportion of the flavor is ≤0.5%.

[0032] The gel-type cleanser provided by the invention contains a breath freshener, a cooling agent and an essence, and has the effects of refreshing breath, refreshing the mind and making people feel happy.

[0033] The weight in the above-mentioned gel-type cleaning agent product with rapid sterilization and tooth care functions can be known weight units such as μg, mg, g, kg, etc., or multiples thereof, such as 1 / 10, 1 / 100, 10 times, 100 times, etc.

[0034] The present invention also provides a method for preparing the gel-type cleaning agent for a dental appliance as described above, comprising:

[0035] Mixing the gelling agent and the water to make the gelling agent swell, thereby obtaining gel A;

[0036] Adding the bactericide into the gel A and mixing evenly to obtain gel B;

[0037] The biological enzyme is added into the gel B and mixed evenly.

[0038] The method for preparing the gel-type cleaning agent for a dental appliance provided by the present invention further comprises the step of adding a tooth whitening agent and / or fluoride to the gel B and mixing them uniformly when adding the biological enzyme.

[0039] The method for preparing the gel-type cleanser for a dental appliance provided by the present invention further comprises the step of adding a flavoring agent to the gel-type cleanser for a dental appliance.

[0040] The present invention also provides the use of the gel-type cleaning agent for the dental appliance as described above, comprising: applying the gel-type cleaning agent to the inside of the dental appliance and then wearing it on the teeth; preferably, the material of the dental appliance is one or more of thermoplastic polyurethane (TPU), polycarbonate (PC), polyethylene terephthalate-1,4-cyclohexadiene dimethylene terephthalate (PETG) and ethylene-vinyl acetate copolymer (EVA). The gel-type cleaning agent in the present invention is particularly suitable for a dental appliance made of thermoplastic polyurethane (TPU) or polyethylene terephthalate-1,4-cyclohexadiene dimethylene terephthalate (PETG), which has excellent stability and mechanical properties.

[0041] According to the application of the gel-type cleanser for a dental appliance provided by the present invention, the amount of the gel-type cleanser applied to the dental appliance is 1 to 20 g.

[0042] According to the application of the gel-type cleanser for a dental appliance provided by the present invention, the gel-type cleanser on the dental appliance is directly washed away with water.

[0043] The gel-type cleaning agent for a dental appliance provided by the present invention can penetrate well into the part close to the tip of the tooth and the depression of the attachment due to its gel state, and can continuously maintain stable and excellent bactericidal performance during long-term wearing, avoiding the decline of indicators such as the transparency of the dental appliance due to the extended wearing time, affecting the bactericidal effect and appearance; after taking it out, it can be washed with water to remove the residual cleaning agent, without damaging the surface of the dental appliance, and even more without destroying the mechanical properties of the dental appliance. Moreover, other components in the gel-type cleaning agent, such as tooth whitening agents and biological enzymes, can also act on the tooth surface for a long time during long-term wearing, and have the effects of whitening teeth, inhibiting the growth of oral bacteria, and maintaining healthy gums.

[0044] The gel-type cleaner for dental orthodontic appliances provided by the present invention has a short sterilization time and can kill Streptococcus mutans, Lactobacillus and Candida albicans within 1 minute. The bacteria killing rate is as high as 99.999%, and it has a good sterilization effect; it can also promote tooth remineralization and care for teeth; it can inhibit the mineralization of dental plaque and prevent the appearance of new stains; it has the effects of refreshing breath and refreshing the mind.

[0045] The preparation method of the gel-type cleaning agent for a dental appliance provided by the present invention is simple, the process is easy to control, and the effect is stable.

[0046] The application of the gel-type cleaner for dental braces provided by the present invention is completely different from the traditional soaking and brushing. It is colorless and transparent and can be placed on the inner surface of the dental braces by smearing when the dental braces are worn, which is also beneficial to the wearing of the braces. DETAILED DESCRIPTION

[0047] In order to make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention is described clearly and completely below. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0048] If no specific techniques or conditions are specified in the examples, the techniques or conditions described in the literature in the field or the product instructions are used. If no manufacturer is specified for the reagents or instruments used, they are all conventional products that can be purchased through regular channels.

[0049] Examples 1 to 10

[0050] (1) Weigh the raw materials according to the formula of Examples 1 to 10 in Table 1;

[0051] (2) adding the gelling agent into water and stirring to make the gelling agent swell to obtain gel A;

[0052] (3) Add the fungicide to gel A and stir evenly to obtain gel B;

[0053] (4) adding a tooth whitening agent, fluoride and a biological enzyme to gel B in sequence and stirring the mixture to obtain gel C;

[0054] (5) Add the breath freshener, cooling agent and fragrance into the gel C in sequence and stir evenly to obtain a gel-type cleanser.

[0055] Table 1

[0056]

[0057]

[0058]

[0059] Comparative Example 1

[0060] A cleaning agent, whose formula and preparation process are substantially the same as those of Example 1, except that the gel in Example 1 is replaced by polyvidone K30 (PVP).

[0061] Comparative Example 2

[0062] A cleaning agent, whose formula and preparation process are basically the same as those of Example 1, except that the biological enzyme in Example 1 is replaced by water.

[0063] Comparative Example 3

[0064] A cleaning agent, whose formula and preparation process are basically the same as those in Example 1, except that the bactericide in Example 1 is replaced by hydrogen peroxide (H 2 O 2 ).

[0065] Test Example 1

[0066] The bactericidal effects of the gel-type cleaning agents in Examples 1 to 10 were tested, and the selected bacterial species were Streptococcus mutans, Lactobacillus and Candida albicans.

[0067] Preparation of bacterial suspension: Use 5 ml of sterile distilled water to dilute the Streptococcus mutans, Lactobacillus, and Candida albicans cultured for 24 hours with 0.03 mol phosphate buffer to form bacterial suspension.

[0068] Quantitative sterilization test of bacterial suspension: Take 5.0 ml of the gel-type detergent aqueous solution in Examples 1 to 10 (the ratio of gel to water is 1:1) in a sterile test tube, then take 0.1 ml of the bacterial suspension and add it to 5.0 ml of the gel-type detergent aqueous solution in Examples 1 to 10 and mix well. After 1 minute of action, take 1 ml of the bacterial drug mixture and add it to a sterile test tube containing 5 ml of neutralizer and mix well. After 10 minutes of neutralization, take 1.0 ml of the liquid and inoculate a sterile plate, pour ordinary nutrient agar medium, and incubate it in an incubator at 37°C for 24 hours (Streptococcus mutans, Lactobacillus), 48 hours (Candida albicans), count the number of colonies on the plate, and average the experiment three times, take the average value, and calculate the sterilization rate. The test results are shown in Table 2.

[0069] Table 2 Bactericidal effect of gel-type cleaners

[0070]

[0071]

[0072] As can be seen from Table 2, the gel-type detergent of the present invention kills Streptococcus mutans, Lactobacillus, and Candida albicans within 1 minute. The sterilization rate is high, the sterilization is fast, and the bacteria can be killed quickly and thoroughly. Comparative Example 1 uses povidone K30 as a gel. Since povidone K30 has strong complexation with the functional substances of plant-type bactericides, such as gingerol and paeonol, the bactericidal efficacy of the plant-type bactericide is reduced, and the sterilization rate of the detergent is reduced. Comparative Example 2 does not use biological enzymes, and the sterilization rate of the detergent is reduced. Comparative Example 3 uses hydrogen peroxide as a bactericide, which causes the gel-type detergent to have strong oxidizing properties, conflicts with the biological enzyme, and the sterilization rate of the system is reduced.

[0073] Test Example 2

[0074] The pH values ​​of the gel-type cleansers in Examples 1 to 10 were measured.

[0075] Test method: The pH value of the gel-type cleansers in Examples 1 to 10 of the present invention was tested according to the pH value test method specified in the "Sterilization Technical Specifications" (2002 edition). 50 ml of each gel-type cleanser in Examples 1 to 10 was placed in a beaker, and its pH value was measured. The test results are shown in Table 3.

[0076] Table 3 pH value of gel-type cleaner

[0077]

[0078]

[0079] Test Example 3

[0080] The stability of the gel-type cleansers in Examples 1 to 10 was measured.

[0081] Test method: The stability of the gel-type cleansers in Examples 1 to 10 of the present invention was tested according to the test method in the "Sterilization Technical Specification". The gel-type cleansers in Examples 1 to 10 were placed in a 37°C incubator for 90 days and then taken out to observe the appearance of the gel-type cleansers in Examples 1 to 10. The gel-type cleansers in Examples 1 to 10 were stable without stratification.

[0082] Determine the content of effective bactericidal ingredients in gel-type cleaners before and after 90 days of storage; measure the contents of chlorhexidine acetate, chlorhexidine gluconate, polyhexamethylene biguanide, polyhexamethylene guanidine and polyhexamethylene guanidine salt in accordance with "GB / T 26367-2020 Hygiene Requirements for Guanidine Disinfectants"; test the contents of gingerol and gingerol in ginger root extract, as well as paeonol, thymol, catechins and hydrogen peroxide in accordance with the 2020 edition of the "Chinese Pharmacopoeia"; test the content of hydrogen peroxide according to the potassium permanganate method; calculate the decline rate of effective bactericidal ingredients through the changes in the content of effective bactericides.

[0083] Calculation formula: effective bactericidal component decline rate = (effective bactericidal component content before storage - effective bactericidal component content after storage) / effective bactericidal component content before storage × 100%.

[0084] The test results are shown in Table 4.

[0085] Table 4 Decrease rate of effective bactericidal component content in gel-type cleaners

[0086]

[0087]

[0088] As shown in Table 4, the gel-type cleanser of the present invention is relatively stable, and the content of effective bactericidal components does not change much after long-term storage, and can maintain a good bactericidal effect for a long time. Comparative Example 3 Hydrogen peroxide is used as a bactericide, which has poor stability. After storage at 37°C for 90 days, the effective bactericidal component decreases by 27.8%.

[0089] Test Example 4

[0090] The long-lasting bactericidal performance of the gel-type cleansers in Examples 1 to 10 was measured.

[0091] The gel-type cleansers in Examples 1 to 10 were stored in a 37° C. incubator for 90 days and then taken out. The bactericidal effects of the gel-type cleansers in Examples 1 to 10 were tested according to the method of Test Example 1. The selected bacterial species were Streptococcus mutans, Lactobacillus and Candida albicans.

[0092] The test results are shown in Table 5.

[0093] Table 5 Bactericidal effect of gel-type cleaner after 90 days of storage

[0094]

[0095]

[0096] As can be seen from Table 5, after being placed for 90 days, the gel-type cleaning agent of the present invention can still quickly kill Streptococcus mutans, Lactobacillus and Candida albicans within 1 minute, and has a long-lasting and stable bactericidal performance. Comparative Example 1 uses polyvidone K30 as a gelling agent, and since polyvidone K30 has a strong complexation with polyphenol compounds, the bactericidal rate of the cleaning agent is reduced to 99.9%. After being placed for 90 days, the bactericidal rate of the cleaning agent in Comparative Example 2 is still 99.99%. Comparative Example 3 uses hydrogen peroxide as a bactericide. After being placed for 90 days, the hydrogen peroxide content decreases, and the bactericidal rate of the system is reduced to 99%.

[0097] Test Example 5

[0098] The effects of the gel-type cleansers in Examples 1 to 10 on the performance of the orthodontic appliance when used for a long period of time were determined.

[0099] Thermoplastic polyurethane (TPU) dental appliance materials were processed into 100 samples with a size of 50.8 mm × 12.7 mm × 1.0 mm and randomly divided into ten groups (each group had 10 samples). For all groups of samples, 10 g of the gel in Examples 1 to 10 was applied to both sides twice a week (Monday and Thursday), and then soaked in saliva; before each application, the appliance samples were washed with running water and replaced with fresh saliva for a total of 6 months. The transmittance, surface roughness and tensile elastic modulus of the dental appliance materials were tested. The test method of light transmittance of dental appliance materials is based on the literature Spink LS, Rungruanganut P, ​​Megremis S, Kelly JR. Comparison of an absolute and surrogate measure of relative translucency in dental ceramics. Dent Mater. 2013; 29: 702–707. The light transmittance of dental appliance materials was measured using a spectrophotometer. The surface roughness of the appliance materials was measured using a surface profiler. The tensile elastic modulus of the appliance materials was measured using a universal mechanical testing machine.

[0100] The test results are shown in Table 6;

[0101] Table 6 Properties of orthodontic materials

[0102]

[0103] As shown in Table 6, the gel-type cleaner of the present invention was applied and soaked on the thermoplastic polyurethane dental appliance material for up to 6 months, and the light transmittance, surface roughness and tensile elastic modulus of the material did not change significantly. Long-term use of the gel-type cleaner of the present invention had no adverse effect on the performance of the appliance. However, in Comparative Example 3, hydrogen peroxide was used as a bactericide, which has strong oxidizing properties, resulting in the surface roughness of the thermoplastic polyurethane dental appliance material increasing to 0.21 μm, the transparency decreasing to 82%, and the tensile elastic modulus also decreasing to 803.2 MPa.

[0104] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A gel-type cleaning agent for a dental appliance, characterized in that: Including: gel, bactericide, biological enzyme and water; The gelling agent is one or more of cellulose gum, guar gum, xanthan gum, sodium alginate, chitosan, polyvinyl alcohol and carbomer; the bactericide is a guanidine bactericide and a plant bactericide; the biological enzyme is one or more of glucose oxidase, dextranase, protease, amylase, lysozyme and superoxide dismutase; In the gel-type cleaner, the mass ratio of the gel to the bactericide is 1-10:0.01-5.0, the mass ratio of the gel to the biological enzyme is 1-10:0.01-5, and the mass fraction of the gel is 1-10%; The guanidine fungicide is at least one of chlorhexidine acetate, chlorhexidine gluconate, polyhexamethylene biguanide, polyhexamethylene guanidine and polyhexamethylene guanidine salt; the plant fungicide is at least one of ginger root extract, ginger essential oil, paeonol, thymol, eucalyptol, honeysuckle extract, magnolia bark extract, catechin and grapefruit extract.

2. The gel-type cleaning agent for dental braces according to claim 1, characterized in that: Also included: tooth whiteners and / or fluoride; The tooth whitening agent is one or more of sodium phytate, sodium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate and sodium ethylenediaminetetraacetate; The fluoride is one or more of sodium monofluorophosphate, sodium fluoride and strontium fluoride.

3. The gel-type cleaning agent for a dental appliance according to claim 2, characterized in that: The mass ratio of the gel to the tooth whitening agent is 1-10:0.1-10.0; And / or, the mass ratio of the gelling agent to the fluoride is 1-10:0.1-10.

0.

4. The gel-type cleaning agent for a dental appliance according to claim 3, characterized in that: The mass ratio of the gel to the tooth whitening agent is 1-10:0.1-8.

0.

5. The gel-type cleaning agent for a dental appliance according to claim 3, characterized in that: The mass ratio of the gelling agent to the fluoride is 1-10:0.1-5.

0.

6. The gel-type cleaning agent for a dental appliance according to any one of claims 1 to 5, characterized in that Also included: flavoring agent; the flavoring agent is one or more of a breath freshener, a cooling agent and an essence.

7. The gel-type cleaning agent for a dental appliance according to claim 6, characterized in that: The breath freshener is one or more of zinc citrate, 0-cymene-5-ol, tea extract, licorice extract and Zanthoxylum bungeanum extract; And / or, the cooling agent is menthol and / or borneol; And / or, the flavor is at least one of floral, fruity, tea, minty, and marine.

8. The gel-type cleaning agent for a dental appliance according to claim 6, characterized in that: The mass proportion of the breath freshener is ≤0.5%; And / or, the mass proportion of the cooling agent is ≤0.5%; And / or, the mass proportion of the flavor is ≤0.5%.

9. The method for preparing a gel-type cleaning agent for a dental appliance according to any one of claims 1 to 8, characterized in that: include: Mixing the gelling agent and the water to make the gelling agent swell, thereby obtaining gel A; Adding the bactericide into the gel A and mixing evenly to obtain gel B; The biological enzyme is added into the gel B and mixed evenly.

10. The method for preparing a gel-type cleaning agent for a dental appliance according to claim 9, characterized in that: The method further comprises the steps of: adding a tooth whitening agent and / or fluoride into the gel B and mixing the mixture evenly when adding the biological enzyme; The tooth whitening agent is one or more of sodium phytate, sodium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate and sodium ethylenediaminetetraacetate; The fluoride is one or more of sodium monofluorophosphate, sodium fluoride and strontium fluoride.

11. The method for preparing a gel-type cleaning agent for a dental appliance according to claim 9 or 10, characterized in that: The step also includes: adding a flavoring agent to the gel-type cleaning agent for the dental appliance; The flavoring agent is one or more of a breath freshener, a cooling agent and an essence.

12. The method for preparing a gel-type cleaning agent for a dental appliance according to claim 11, characterized in that: The breath freshener is one or more of zinc citrate, 0-cymene-5-ol, tea extract, licorice extract and Zanthoxylum bungeanum extract; And / or, the cooling agent is menthol and / or borneol; And / or, the flavor is at least one of floral, fruity, tea, minty, and marine.

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