Method and apparatus for testing hollow fiber oxygenation membranes of a membrane oxygenator, system

Abstract

This disclosure relates to a testing method, apparatus, and system for a hollow fiber oxygenation membrane in a membrane oxygenator. The method includes: controlling the flow of feed liquid in a feed liquid storage device in a sequential manner, passing through the output end of the feed liquid storage device, the input end of a membrane module, the output end of the membrane module, and the input end of the feed liquid storage device, wherein the membrane module is made of the hollow fiber oxygenation membrane to be tested; determining the mass transfer rate of oxygen and / or carbon dioxide in the membrane module at various times; and determining that feed liquid leakage has occurred in the membrane module when the mass transfer rate of oxygen and / or carbon dioxide in the membrane module begins to decrease at a rate greater than a preset decrease rate, and the decrease reaches or exceeds a preset range, and determining the duration of feed liquid leakage resistance of the membrane module. Embodiments of this disclosure can provide real-time feedback on the oxygenation performance of the oxygenation membrane, accurately determine the duration of feed liquid leakage resistance of the oxygenation membrane (i.e., the hollow fiber oxygenation membrane), and achieve accurate prediction of the oxygenation performance and service life of the hollow fiber membrane.

Description

TECHNICAL FIELD

[0001] The present disclosure relates to the technical field of testing, in particular to a testing method, device and system for hollow fiber oxygenation membrane of a membrane oxygenator. BACKGROUND

[0002] Extracorporeal Membrane Oxygenation (ECMO) system has the function of replacing the human lung to regulate the oxygen and carbon dioxide content in the blood, and has become an important medical device in the treatment of acute respiratory disease, waiting for lung transplantation stage and cardiovascular surgery process. ECMO is composed of a membrane oxygenator, a blood pump, a gas mixer, and various pipelines and monitors. The membrane oxygenator is the key place for gas-blood exchange and is the core component of the ECMO system.

[0003] The oxygenation membrane in the membrane oxygenator has a working principle similar to that of alveoli, which utilizes the difference in oxygen and carbon dioxide partial pressure between blood and gas on both sides of the membrane to achieve the removal of carbon dioxide and the replenishment of oxygen in the blood. At the same time, the oxygenation membrane always prevents direct contact between gas and blood, avoiding the occurrence of adverse symptoms such as gas embolism. However, during long-term use of the oxygenator, plasma will inevitably leak into the internal pores of the oxygenation membrane, which will lead to a decrease in gas permeation efficiency and ultimately result in failure of the oxygenator. Therefore, the oxygenation membrane needs to have good gas permeation performance and resistance to plasma leakage.

[0004] However, there is no uniform standard for the performance evaluation of hollow fiber membranes for membrane oxygenators at present, and the testing method and determination standard are still in the exploratory stage, so it is urgent to propose a technical solution that can truly feedback the oxygenation performance of the membrane. SUMMARY

[0005] According to an aspect of the present disclosure, a testing method for a hollow fiber oxygenation membrane of a membrane oxygenator is provided, the method comprising:

[0006] controlling the circulation of a feed liquid in a feed liquid reservoir in an order of an output end of the feed liquid reservoir, an input end of a membrane assembly, an output end of the membrane assembly, and an input end of the feed liquid reservoir, the membrane assembly being made of a hollow fiber oxygenation membrane to be tested, and the carbon dioxide concentration and oxygen concentration of the feed liquid in the feed liquid reservoir being constant;

[0007] determining the mass transfer rate of oxygen and / or carbon dioxide of the membrane assembly at each time point;

[0008] In the case that the mass transfer rate of oxygen and / or carbon dioxide of the membrane module starts to decrease at a rate greater than the preset decreasing rate and the decreasing amplitude reaches or exceeds the preset amplitude, it is determined that the membrane module has a feed liquid leakage phenomenon, and the feed liquid leakage resistance duration of the membrane module is determined as the duration between the time when the feed liquid starts to flow and the time when the mass transfer rate starts to decrease at a rate greater than the preset decreasing rate.

[0009] In a possible implementation, the determining the mass transfer rate of oxygen and / or carbon dioxide of the membrane module at each time point comprises:

[0010] obtaining the dissolved oxygen content and / or the dissolved carbon dioxide content of the input end of the membrane module and the output end of the membrane module at each time point, obtaining the feed liquid flow rate flowing through the membrane module at each time point, the effective outer surface area of the hollow fiber oxygenation membrane to be tested, and the molar mass of oxygen and / or carbon dioxide;

[0011] determining the mass transfer rate of oxygen of the membrane module at each time point according to the dissolved oxygen content of the input end of the membrane module and the output end of the membrane module at each time point, the feed liquid flow rate flowing through the membrane module at each time point, the effective outer surface area, and the molar mass of oxygen; and / or

[0012] determining the mass transfer rate of carbon dioxide of the membrane module at each time point according to the dissolved carbon dioxide content of the input end of the membrane module and the output end of the membrane module at each time point, the feed liquid flow rate flowing through the membrane module at each time point, the effective outer surface area, and the molar mass of carbon dioxide.

[0013] In a possible implementation, the method further comprises:

[0014] adjusting the feed liquid pressure in the membrane module and / or the feed liquid flow rate flowing through the membrane module, and determining the feed liquid leakage resistance duration of the membrane module under different feed liquid pressures and / or different feed liquid flow rates;

[0015] determining the relationship between the feed liquid pressure and / or the feed liquid flow rate and the feed liquid leakage resistance duration of the membrane module according to the feed liquid leakage resistance duration of the membrane module under different feed liquid pressures and / or different feed liquid flow rates.

[0016] In a possible implementation, before circulating the feed liquid in the feed liquid reservoir in the order of the output end of the feed liquid reservoir, the input end of the membrane module, the output end of the membrane module, and the input end of the feed liquid reservoir, the method further comprises:

[0017] adjusting the carbon dioxide concentration and the oxygen concentration in the feed liquid reservoir until the carbon dioxide concentration and the oxygen concentration in the feed liquid reservoir reach a steady state.

[0018] In a possible implementation, the preset amplitude is 40% to 80%, and an oxygen source is arranged near the membrane module.

[0019] In a possible implementation, the feed liquid includes any one of pure water, normal saline, blood, or simulated blood.

[0020] According to an aspect of the present disclosure, a testing device for a hollow fiber oxygenation membrane of a membrane oxygenator is provided, and the device includes:

[0021] A control module is configured to control the feed liquid in the feed liquid reservoir to flow in a sequence of an output end of the feed liquid reservoir, an input end of the membrane module, an output end of the membrane module, and an input end of the feed liquid reservoir, the membrane module is made of the hollow fiber oxygenation membrane to be tested, and a carbon dioxide concentration and an oxygen concentration of the feed liquid in the feed liquid reservoir are constant;

[0022] A first determination module is configured to determine a mass transfer rate of oxygen and / or carbon dioxide of the membrane module at each time point;

[0023] A second determination module is configured to determine that the membrane module has a feed liquid leakage phenomenon and determine a feed liquid leakage resistance duration of the membrane module as a duration between a time when the feed liquid starts to flow and a time when the mass transfer rate of oxygen and / or carbon dioxide of the membrane module starts to decrease at a rate greater than a preset decreasing rate, in a case that the mass transfer rate of oxygen and / or carbon dioxide of the membrane module starts to decrease at a rate greater than the preset decreasing rate and a decreasing amplitude reaches or exceeds a preset amplitude.

[0024] In a possible implementation, the determination of the mass transfer rate of oxygen and / or carbon dioxide of the membrane module at each time point includes:

[0025] The dissolved oxygen detector is configured to obtain dissolved oxygen content and / or dissolved carbon dioxide content of the input end of the membrane module and the output end of the membrane module at each time point, the feed liquid flow detector is configured to obtain a feed liquid flow rate flowing through the membrane module at each time point, and the effective outer surface area of the hollow fiber oxygenation membrane to be tested is obtained, and a molar mass of oxygen and / or carbon dioxide is obtained;

[0026] The mass transfer rate of oxygen of the membrane module at each time point is determined according to the dissolved oxygen content of the input end of the membrane module and the output end of the membrane module at each time point, the feed liquid flow rate flowing through the membrane module at each time point, the effective outer surface area, and the molar mass of oxygen; and / or

[0027] The mass transfer rate of carbon dioxide of the membrane module at each time is determined according to the input end of the membrane module, the dissolved carbon dioxide content of the output end of the membrane module at each time, the feed liquid flow rate flowing through the membrane module at each time, the effective outer surface area, and the molar mass of carbon dioxide.

[0028] In a possible implementation, the device further comprises:

[0029] The adjusting module is configured to adjust the feed liquid pressure in the membrane module and / or the feed liquid flow rate flowing through the membrane module, and determine the feed liquid leakage resistance duration of the membrane module under different feed liquid pressures and / or different feed liquid flow rates.

[0030] The relationship determining module is configured to determine the relationship between the feed liquid pressure and / or the feed liquid flow rate and the feed liquid leakage resistance duration of the membrane module according to the feed liquid leakage resistance duration of the membrane module under different feed liquid pressures and / or different feed liquid flow rates.

[0031] According to an aspect of the present disclosure, there is provided a test system for a hollow fiber oxygenation membrane of a membrane oxygenator, the system comprising a feed solution reservoir, a pump, a first dissolved gas detector, a second dissolved gas detector, a membrane module, a first feed solution pressure detector, a second feed solution pressure detector, a first gas pressure detector, a second gas pressure detector, a first gas flow detector, a second gas flow detector, a feed solution flow rate detector, a feed solution pressure regulating valve, a feed solution flow rate regulating valve, and a controller, the membrane module being made of the hollow fiber oxygenation membrane to be tested, wherein: an output of the feed solution reservoir, the pump, the membrane module, and an input of the feed solution reservoir are connected by transmission pipelines, the feed solution reservoir is configured to store a feed solution, the pump is configured to pump the feed solution from the output of the feed solution reservoir to an input of the membrane module, the first dissolved gas detector is disposed at the input of the membrane module and configured to detect a dissolved oxygen content and / or a dissolved carbon dioxide content at the input of the membrane module, the second dissolved gas detector is disposed at an output of the membrane module and configured to detect a dissolved oxygen content and / or a dissolved carbon dioxide content at the output of the membrane module, the first feed solution pressure detector is disposed at the input of the membrane module and configured to detect a feed solution pressure at the input of the membrane module, the second feed solution pressure detector is disposed at the output of the membrane module and configured to detect a feed solution pressure at the output of the membrane module, the first gas pressure detector is disposed at the input of the membrane module and configured to detect an oxygen gas pressure at the input of the membrane module, the second gas pressure detector is disposed at the output of the membrane module and configured to detect an oxygen gas pressure at the output of the membrane module, the first gas flow detector is disposed at the input of the membrane module and configured to detect an oxygen gas flow rate at the input of the membrane module, the second gas flow detector is disposed at the output of the membrane module and configured to detect an oxygen gas flow rate at the output of the membrane module, the feed solution flow rate detector is disposed at the output of the membrane module and configured to detect a feed solution flow rate at the output of the membrane module, the feed solution pressure regulating valve is disposed between the output of the membrane module and the input of the feed solution reservoir and configured to regulate a feed solution pressure of the feed solution flowing through the membrane module, the feed solution flow rate regulating valve is disposed between the input of the membrane module and a connection point of the pump, and between the input of the feed solution reservoir, and configured to regulate a feed solution flow rate of the feed solution flowing through the membrane module,

[0032] the controller is connected to the pump, the first dissolved gas detector, the second dissolved gas detector, the first feed solution pressure detector, the second feed solution pressure detector, the first gas pressure detector, the second gas pressure detector, the first gas flow detector, the second gas flow detector, the feed solution flow rate detector, the feed solution pressure regulating valve, and the feed solution flow rate regulating valve, and the controller is configured to execute the test method for the hollow fiber oxygenation membrane of the membrane oxygenator.

[0033] In an aspect of the present disclosure, an electronic device is provided, comprising: a processor; a memory for storing processor-executable instructions; wherein the processor is configured to invoke the instructions stored in the memory to perform the above method.

[0034] In an aspect of the present disclosure, a computer-readable storage medium is provided, having stored thereon computer program instructions, which when executed by a processor, implement the above method.

[0035] The present disclosure provides a method for testing the oxygenation performance of a hollow fiber oxygenation membrane of a membrane oxygenator. The method comprises: controlling the flow of a feed liquid in a feed liquid reservoir to circulate in an order of an output end of the feed liquid reservoir, an input end of a membrane module, an output end of the membrane module, and an input end of the feed liquid reservoir; setting the carbon dioxide concentration and the oxygen concentration of the feed liquid in the feed liquid reservoir to be constant; determining the mass transfer rate of oxygen and / or carbon dioxide of the membrane module at each time; determining that the membrane module has a feed liquid leakage phenomenon when the mass transfer rate of oxygen and / or carbon dioxide of the membrane module starts to decrease at a rate greater than a preset decreasing rate and the decreasing amplitude reaches or exceeds a preset amplitude; and determining the feed liquid leakage resistance duration of the membrane module as the duration between the time when the feed liquid starts to flow and the time when the mass transfer rate starts to decrease at a rate greater than the preset decreasing rate. The method can provide real-time feedback on the oxygenation performance of the hollow fiber oxygenation membrane, accurately determine the feed liquid leakage resistance duration of the hollow fiber oxygenation membrane, and accurately predict the oxygenation performance and service life of the hollow fiber oxygenation membrane.

[0036] It should be understood that the general description above and the following detailed description below are only exemplary and explanatory, rather than restrictive, of the present disclosure. Other features and aspects of the present disclosure will become apparent from the following detailed description of exemplary embodiments, with reference made to the accompanying drawings. BRIEF DESCRIPTION OF DRAWINGS

[0037] The accompanying drawings, which are incorporated into and form a part of the specification, illustrate examples consistent with the present disclosure and, together with the description, serve to explain the technical solutions of the present disclosure.

[0038] Figure 1 A flowchart of a test method for a hollow fiber oxygenation membrane of a membrane oxygenator according to an embodiment of the present disclosure is shown.

[0039] Figure 2 A schematic diagram of a test system for a hollow fiber oxygenation membrane of a membrane oxygenator according to an embodiment of the present disclosure is shown.

[0040] Figure 3 A test effect schematic diagram according to an embodiment of the present disclosure is shown.

[0041] Figure 4 A schematic diagram of a membrane module according to an embodiment of the present disclosure is shown.

[0042] Figure 5 A flowchart of a testing method of a hollow fiber oxygenation membrane of a membrane oxygenator is shown.

[0043] Figure 6 A block diagram of a testing device of a hollow fiber oxygenation membrane of a membrane oxygenator is shown.

[0044] Figure 7 A block diagram of an electronic device according to an embodiment of the present disclosure is shown.

[0045] Figure 8 A block diagram of an electronic device according to an embodiment of the present disclosure is shown. DETAILED DESCRIPTION

[0046] Various exemplary embodiments, features and aspects of the present disclosure will be described in detail below with reference to the accompanying drawings. The same reference numbers in different drawings represent the same or similar elements. Although various aspects of the embodiments are illustrated in the drawings, the drawings are not necessarily drawn to scale unless specifically indicated.

[0047] In the description of the present disclosure, it should be understood that the terms "length", "width", "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like indicate the orientation or positional relationship shown in the drawings based on the orientation or positional relationship shown in the drawings, and are only for the purpose of facilitating the description of the present disclosure and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present disclosure.

[0048] In addition, the terms "first", "second", "third", etc. are only used for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, the features defined with "first", "second", etc. can explicitly or implicitly include one or more of the features. In the description of the present disclosure, the meaning of "a plurality of" is two or more, unless otherwise explicitly specified and limited.

[0049] In the present disclosure, unless otherwise explicitly specified and limited, the terms "mounting", "connection", "connecting", "fixing" and the like should be understood broadly, for example, can be fixed connection, can also be detachable connection, or integral; can be mechanical connection, can also be electrical connection; can be directly connected, can also be indirectly connected through an intermediate medium; can be the internal communication of two elements or the interaction relationship between two elements. For those skilled in the art, the specific meaning of the above terms in the present disclosure can be understood according to the specific circumstances.

[0050] The term "exemplary" is used herein to mean "serving as an example, instance, or illustration." Any embodiment described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments.

[0051] The term "and / or", used herein only to represent an association relationship of associated objects, means that there can be three relationships, for example, A and / or B, which can represent three cases of A existing alone, A and B existing together, and B existing alone. In addition, the term "at least one" herein means any one of a plurality or any combination of at least two of a plurality, for example, including at least one of A, B, and C, which can mean including any one or more elements selected from the set consisting of A, B, and C.

[0052] In addition, in order to better illustrate the present disclosure, numerous specific details are given in the specific embodiments below. Those skilled in the art should understand that the present disclosure can also be implemented without certain specific details. In some examples, methods, means, elements and circuits well known to those skilled in the art are not described in detail, in order to highlight the main idea of the present disclosure.

[0053] The related art has technical solutions for determining gas permeation performance by measuring gas flux, and technical solutions for defining the time when the weight of the collected permeated liquid significantly increases, i.e., the first significant increase in permeated liquid, as the plasma leakage time, and technical solutions for defining the time when anhydrous copper sulfate changes color as the plasma leakage time. These technical solutions cannot reflect the plasma infiltration and oxygenation performance degradation of the oxygenation membrane in real time, and cannot truly reflect the oxygenation performance of the oxygenation membrane.

[0054] The embodiments of the present disclosure propose a test method for a hollow fiber oxygenation membrane of a membrane type oxygenator. The method controls the circulation of the feed liquid in the feed liquid reservoir in the order of the output end of the feed liquid reservoir, the input end of the membrane module, the output end of the membrane module, and the input end of the feed liquid reservoir, sets the carbon dioxide concentration and oxygen concentration of the feed liquid in the feed liquid reservoir constant, and determines the mass transfer rate of oxygen and / or carbon dioxide of the membrane module at each time. In the case where the mass transfer rate of oxygen and / or carbon dioxide of the membrane module starts to decrease at a rate greater than a preset decrease rate and the decrease amplitude reaches or exceeds a preset amplitude, it is determined that the membrane module has a feed liquid leakage phenomenon, and the feed liquid leakage resistance duration of the membrane module is determined as the duration between the time when the feed liquid starts to flow and the time when the mass transfer rate starts to decrease at a rate greater than the preset decrease rate. The method can provide real-time feedback on the oxygenation performance of the oxygenation membrane, accurately determine the feed liquid leakage resistance duration of the oxygenation membrane, i.e., the hollow fiber oxygenation membrane, and accurately predict the oxygenation performance and service life of the hollow fiber membrane.

[0055] The subject performing the method can be an apparatus. For example, the method can be performed by a terminal device or a server or other processing device. Among them, the terminal device can be a user equipment (User Equipment, UE), a mobile device, a user terminal, a terminal, a handheld device, a computing device, or a vehicle-mounted device, etc. For example, some terminals include mobile phones, tablets, notebook computers, palmtop computers, mobile Internet devices (Mobile Internet device, MID), wearable devices, virtual reality (Virtual Reality, VR) devices, augmented reality (Augmented reality, AR) devices, wireless terminals in industrial control, wireless terminals in self-driving, wireless terminals in remote medical surgery, wireless terminals in smart grids, wireless terminals in transportation safety, wireless terminals in smart cities, wireless terminals in smart homes, wireless terminals in Internet of Vehicles, etc. For example, the server can be a local server or a cloud server.

[0056] In some possible implementations, the method can be implemented by a processing component invoking computer-readable instructions stored in a memory. In one example, the processing component includes, but is not limited to, a single processor, or a discrete component, or a combination of a processor and a discrete component. The processor can include a controller having a function of executing instructions in an electronic device, and the processor can be implemented in any appropriate manner, for example, by one or more application specific integrated circuits (ASIC), digital signal processors (DSP), digital signal processing devices (DSPD), programmable logic devices (PLD), field programmable gate arrays (FPGA), controllers, microcontrollers, microprocessors or other electronic elements. Inside the processor, the executable instructions can be executed by hardware circuits such as logic gates, switches, application specific integrated circuits (ASIC), programmable logic controllers and embedded microcontrollers.

[0057] Please refer to Figure 1 , Figure 1 A flowchart of a test method for a hollow fiber oxygenation membrane of a membrane oxygenator is shown in accordance with embodiments of the present disclosure.

[0058] As Figure 1 shown, the method includes:

[0059] Step S11, circulating the liquid in the liquid storage device in the order of the output end of the liquid storage device, the input end of the membrane assembly, the output end of the membrane assembly, and the input end of the liquid storage device, the membrane assembly being made of the hollow fiber oxygenation membrane to be tested, the carbon dioxide concentration and the oxygen concentration of the liquid in the liquid storage device being constant;

[0060] Step S12, determining the mass transfer rate of oxygen and / or carbon dioxide of the membrane assembly at each time point;

[0061] Step S13, in the case that the mass transfer rate of oxygen and / or carbon dioxide of the membrane assembly starts to decrease at a rate greater than the preset decrease rate and the decrease amplitude reaches or exceeds the preset amplitude, determining that the membrane assembly has the liquid leakage phenomenon, and determining the liquid leakage resistance duration of the membrane assembly as the duration between the time when the liquid starts to flow and the time when the mass transfer rate starts to decrease at a rate greater than the preset decrease rate.

[0062] The type of the hollow fiber oxygenation membrane to be tested is not limited in the embodiments of the present disclosure, and the implementation of packaging the hollow fiber oxygenation membrane to be tested into a membrane assembly is not limited, and those skilled in the art can test various types of oxygenation membranes according to actual conditions and needs, and select a suitable way for packaging. For example, the hollow fiber oxygenation membrane to be tested can be a PP hollow fiber membrane, a PMP hollow fiber membrane, etc. The hollow fiber oxygenation membrane to be tested can be a mature membrane for commercial application, or a self-made one, or a defective one. The embodiments of the present disclosure do not make any limitation on this. For example, when packaging, the membrane effective area of the hollow fiber oxygenation membrane to be tested can be controlled within a suitable range, for example, it can be 80cm 2 ~120cm 2 , preferably, it can be 100cm 2 , so as to improve the testing efficiency.

[0063] The type of the liquid is not limited in the embodiments of the present disclosure, and those skilled in the art can select as needed to realize the performance test of the hollow fiber oxygenation membrane to be tested under various types of liquids. In one possible implementation, the liquid includes any one of pure water, physiological saline, blood or simulated blood, etc.

[0064] The hardware architecture of the system for testing the hollow fiber oxygenation membrane is not limited in the embodiments of the present disclosure, and the specific implementation of controlling the liquid in the liquid storage device to circulate in the order of the output end of the liquid storage device, the input end of the membrane assembly, the output end of the membrane assembly, and the input end of the liquid storage device is not limited. For the convenience of understanding, the following is exemplarily introduced.

[0065] Please refer to Figure 2 , Figure 2A schematic diagram of a test system for a hollow fiber oxygenation membrane of a membrane oxygenator is shown.

[0066] In one example, as shown in Figure 2 The test system for a hollow fiber oxygenation membrane of a membrane oxygenator can include a feed solution reservoir, a pump, a first dissolved gas detector, a second dissolved gas detector, a membrane module, a first feed solution pressure detector, a second feed solution pressure detector, a first gas pressure detector, a second gas pressure detector, a first gas flow detector, a second gas flow detector, a feed solution flow detector, a feed solution pressure regulating valve, a feed solution flow regulating valve, and a controller, the membrane module being made of a hollow fiber oxygenation membrane to be tested, wherein:

[0067] an output of the feed solution reservoir, the pump, the membrane module, and an input of the feed solution reservoir are connected by a transfer conduit,

[0068] the feed solution reservoir is configured to store a feed solution,

[0069] the pump is configured to pump the feed solution from the output of the feed solution reservoir to the input of the membrane module,

[0070] the first dissolved gas detector is disposed at the input of the membrane module and is configured to detect a dissolved oxygen content and / or a dissolved carbon dioxide content at the input of the membrane module,

[0071] the second dissolved gas detector is disposed at the output of the membrane module and is configured to detect a dissolved oxygen content and / or a dissolved carbon dioxide content at the output of the membrane module,

[0072] the first feed solution pressure detector is disposed at the input of the membrane module and is configured to detect a feed solution pressure at the input of the membrane module,

[0073] the second feed solution pressure detector is disposed at the output of the membrane module and is configured to detect a feed solution pressure at the output of the membrane module,

[0074] the first gas pressure detector is disposed at the input of the membrane module and is configured to detect an oxygen gas pressure at the input of the membrane module,

[0075] the second gas pressure detector is disposed at the output of the membrane module and is configured to detect an oxygen gas pressure at the output of the membrane module,

[0076] the first gas flow detector is disposed at the input of the membrane module and is configured to detect an oxygen gas flow at the input of the membrane module,

[0077] the second gas flow detector is disposed at the output of the membrane module and is configured to detect an oxygen gas flow at the output of the membrane module,

[0078] The feed liquid flow detector is arranged at the output end of the membrane module and is used to detect the feed liquid flow at the output end of the membrane module,

[0079] The feed liquid pressure regulating valve is arranged between the output end of the membrane module and the input end of the feed liquid reservoir and is used to regulate the feed liquid pressure of the feed liquid flowing through the membrane module,

[0080] The feed liquid flow regulating valve is arranged between the connection point of the input end of the membrane module and the pump and the input end of the feed liquid reservoir and is used to regulate the feed liquid flow of the feed liquid flowing through the membrane module,

[0081] The controller is connected to the pump, the first dissolved gas detector, the second dissolved gas detector, the first feed liquid pressure detector, the second feed liquid pressure detector, the first gas pressure detector, the second gas pressure detector, the first gas flow detector, the second gas flow detector, the feed liquid flow detector, the feed liquid pressure regulating valve, and the feed liquid flow regulating valve, and the controller is used to:

[0082] The test method of the hollow fiber oxygenation membrane of the membrane oxygenator is executed.

[0083] The specific implementation modes of the feed liquid reservoir, the pump, the first dissolved gas detector, the second dissolved gas detector, the membrane module, the first feed liquid pressure detector, the second feed liquid pressure detector, the first gas pressure detector, the second gas pressure detector, the first gas flow detector, the second gas flow detector, the feed liquid flow detector, the feed liquid pressure regulating valve, the feed liquid flow regulating valve, and the controller are not limited in the embodiments of the present disclosure, and a person skilled in the art can select appropriate hardware implementation according to actual conditions and needs.

[0084] For example, the controller can be the aforementioned processing component. The controller can control the pump to circulate the feed liquid of the feed liquid reservoir in the order of the output end of the feed liquid reservoir, the input end of the membrane module, the output end of the membrane module, and the input end of the feed liquid reservoir, determine the mass transfer rate of oxygen and / or carbon dioxide of the membrane module at each time, determine that the membrane module has a feed liquid leakage phenomenon in the case that the mass transfer rate of oxygen and / or carbon dioxide of the membrane module starts to decrease at a rate greater than a preset decrease rate and the decrease amplitude reaches or exceeds a preset amplitude, and determine the feed liquid leakage resistance duration of the membrane module as the duration between the time when the feed liquid starts to flow and the time when the mass transfer rate starts to decrease at a rate greater than the preset decrease rate, so as to feed back the oxygenation performance of the oxygenation membrane in real time and accurately determine the feed liquid leakage resistance duration of the oxygenation membrane, i.e., the hollow fiber oxygenation membrane, and realize accurate prediction of the oxygenation performance and service life of the hollow fiber membrane.

[0085] Of course, the controller can also be a terminal with a display and a processing component, so that the detection results can be displayed in real time.

[0086] It should be noted that, in order to make the display more simple and clear, Figure 2 Figure 2 The connection relationship between the controller and the first dissolved gas detector, the second dissolved gas detector, the first feed liquid pressure detector, the second feed liquid pressure detector, the first gas pressure detector, the second gas pressure detector, the first gas flow detector, the second gas flow detector, the feed liquid flow detector, the feed liquid pressure regulating valve and the feed liquid flow regulating valve is not shown.

[0087] In one example, as shown in Figure 2 , the test system can also be controlled at a constant temperature, so that the test system becomes a constant temperature system, to approach the actual situation. For example, the temperature of the test system can be 20-40 degrees Celsius.

[0088] In one example, as shown in Figure 2 , the test system can also include a carbon dioxide gas source, an oxygen source, and a third gas flow detector. The third gas flow detector is used to detect the gas flow of carbon dioxide output by the carbon dioxide gas source. The controller can be connected to the valve of the carbon dioxide gas source and the third gas flow detector to regulate the gas flow of carbon dioxide output by the carbon dioxide gas source, so that the concentrations of carbon dioxide and oxygen in the feed liquid reservoir are constant. For example, the oxygen source is used to supplement oxygen for the membrane module. The second gas flow detector can also be used to detect the gas flow of oxygen output by the oxygen source. Similarly, the controller can also control the gas flow output of the oxygen source.

[0089] Please refer to Figure 3 , Figure 3 , which shows a test effect diagram according to an embodiment of the present disclosure.

[0090] In one example, as shown in Figure 3 , taking oxygen as an example, the mass transfer rate of the membrane module at each time can be detected from the start of the test (the start of the feed liquid circulation). Of course, the dissolved oxygen content at the input end (inlet) and the output end (outlet) of the membrane module can also be detected. Figure 3 As can be seen, the mass transfer rate of oxygen only fluctuates slightly from 0 to 800 minutes (min), and is relatively stable. At this time, the oxygenation membrane in the membrane module is in a normal working state. After 800 minutes, the mass transfer rate of oxygen begins to decrease significantly (at a rate greater than a preset decrease rate), and the decrease amplitude is large (the decrease amplitude is greater than a preset amplitude). At this time, the oxygenation membrane in the membrane module has been infiltrated by the feed liquid. Therefore, it can be determined that the membrane module has a feed liquid leakage phenomenon, and the feed liquid leakage resistance duration of the membrane module is the duration between the time when the feed liquid starts to flow and the time when the mass transfer rate begins to decrease at a rate greater than the preset decrease rate (e.g., 800 min). ​

[0091] Exemplarily, the phenomenon of the leakage of the feed liquid can refer to the leakage of the feed liquid into the hollow fiber oxygenation membrane, in particular, into the inner hole of the hollow fiber oxygenation membrane, resulting in the decrease of the gas permeation efficiency, and the phenomenon of the failure of the oxygenator.

[0092] Exemplarily, the duration of the resistance of the membrane assembly to the leakage of the feed liquid can refer to the duration of the stable gas mass transfer efficiency of the membrane assembly, in which the gas permeation efficiency of the membrane assembly is high, and the oxygenator functions normally.

[0093] The specific size of the preset decrease rate is not limited in the embodiments of the present disclosure, and can be set by the person skilled in the art according to the actual situation and needs, as long as it can be obviously distinguished from the change rate when the mass transfer efficiency is stable.

[0094] The specific size of the preset amplitude is not limited in the embodiments of the present disclosure, and can be set by the person skilled in the art according to the actual situation and needs, as long as it can be obviously changed compared to the size when the mass transfer efficiency is stable, exemplarily, the preset amplitude is 40% to 80%, such as 50%.

[0095] The membrane assembly is exemplarily introduced as follows.

[0096] Please refer to Figure 4 , Figure 4 A schematic diagram of the membrane assembly according to the embodiments of the present disclosure is shown.

[0097] In one example, as Figure 4 shown, the membrane assembly can be a tubular structure, and a plurality of liquid channel pipes can be arranged at intervals in the main body of the membrane assembly, the hollow fiber oxygenation membrane is arranged on one side of the liquid channel pipe, the liquid channel pipe is closed by sealing glue on both sides, the liquid channel pipe has a main feed liquid inlet for injecting the feed liquid, the hollow fiber oxygenation membrane includes a plurality of gas holes for gas exchange, and gas flow ports are arranged at both ends of the tubular structure of the membrane assembly to facilitate the flow of gas.

[0098] In one example, as Figure 4 shown, during the test, the feed liquid can flow through the liquid channel pipe outside the hollow fiber oxygenation membrane in the membrane assembly, and oxygen gas can flow from the inner cavity of the hollow fiber membrane in the membrane assembly at a set pressure and flow rate.

[0099] Of course, the structure of the membrane assembly is only exemplary, and should not be regarded as a limitation of the embodiments of the present disclosure, and in other embodiments, the person skilled in the art can package the hollow fiber oxygenation membrane into other structures according to the actual situation and needs.

[0100] The specific implementation of determining the mass transfer rate of oxygen and / or carbon dioxide of the membrane assembly at each time is not limited in the embodiments of the present disclosure, and the person skilled in the art can realize it by adopting a suitable way according to the actual situation and needs, which is exemplarily introduced as follows.

[0101] Referring to Figure 5 , Figure 5 A flow chart of a test method for a hollow fiber oxygenation membrane of a membrane oxygenator according to embodiments of the present disclosure is shown.

[0102] In one possible implementation, as Figure 5 shown, the step S12 of determining the mass transfer rate of oxygen and / or carbon dioxide of the membrane module at each time point can include:

[0103] A step S121 of obtaining the dissolved oxygen content and / or the dissolved carbon dioxide content of the input end of the membrane module and the output end of the membrane module at each time point, obtaining the flow rate of the feed liquid flowing through the membrane module at each time point, the effective outer surface area of the hollow fiber oxygenation membrane to be tested, and obtaining the molar mass of oxygen and / or carbon dioxide;

[0104] A step S122 of determining the mass transfer rate of oxygen of the membrane module at each time point according to the dissolved oxygen content of the input end of the membrane module and the output end of the membrane module at each time point, the flow rate of the feed liquid flowing through the membrane module at each time point, the effective outer surface area, and the molar mass of oxygen; and / or

[0105] A step S123 of determining the mass transfer rate of carbon dioxide of the membrane module at each time point according to the dissolved carbon dioxide content of the input end of the membrane module and the output end of the membrane module at each time point, the flow rate of the feed liquid flowing through the membrane module at each time point, the effective outer surface area, and the molar mass of carbon dioxide.

[0106] In one example, the first dissolved gas detector and the second feed liquid pressure detector described above can be used to obtain the dissolved oxygen content and / or the dissolved carbon dioxide content of the input end of the membrane module and the output end of the membrane module at each time point, and the feed liquid flow rate detector described above can be used to obtain the flow rate of the feed liquid flowing through the membrane module at each time point. Of course, this description is exemplary, and those skilled in the art can also implement it in other ways.

[0107] In one example, the step S122 of determining the mass transfer rate of oxygen of the membrane module at each time point according to the dissolved oxygen content of the input end of the membrane module and the output end of the membrane module at each time point, the flow rate of the feed liquid flowing through the membrane module at each time point, the effective outer surface area, and the molar mass of oxygen can include:

[0108] The mass transfer rate of oxygen of the membrane module at each time point is determined by using the formula 1:

[0109]

[0110] C1 (O2), C2 (O2) are the dissolved oxygen content of the input end of the membrane module and the output end of the membrane module respectively, unit: mg / L; Q is the flow rate of the feed liquid flowing through the membrane module, unit: L / min; A is the effective outer surface area of the hollow fiber membrane in the membrane module that can be used for testing (removing the part covered by the potting glue), M (O2) is the molar mass of oxygen, which is 32 g / mol.

[0111] Of course, the above formula is only an exemplary description, and in other embodiments, those skilled in the art can adopt other formulas or make changes to the above formula as needed, as long as the mass transfer rate of oxygen of the membrane module at each moment can be determined according to the dissolved oxygen content of the input end of the membrane module and the output end of the membrane module at each moment, the flow rate of the feed liquid flowing through the membrane module at each moment, the effective outer surface area and the molar mass of oxygen.

[0112] In one example, step S123 determines the mass transfer rate of carbon dioxide of the membrane module at each moment according to the dissolved carbon dioxide content of the input end of the membrane module and the output end of the membrane module at each moment, the flow rate of the feed liquid flowing through the membrane module at each moment, the effective outer surface area and the molar mass of carbon dioxide, which can include:

[0113] The mass transfer rate of carbon dioxide of the membrane module at each moment is determined by formula 2:

[0114]

[0115] C1 (CO2), C2 (CO2) are the dissolved carbon dioxide content of the input end of the membrane module and the output end of the membrane module respectively, M (CO2) is the molar mass of carbon dioxide, which is 44 g / mol.

[0116] Of course, the above formula is only an exemplary description, and in other embodiments, those skilled in the art can adopt other formulas or make changes to the above formula as needed, as long as the mass transfer rate of carbon dioxide of the membrane module at each moment can be determined according to the dissolved carbon dioxide content of the input end of the membrane module and the output end of the membrane module at each moment, the flow rate of the feed liquid flowing through the membrane module at each moment, the effective outer surface area and the molar mass of carbon dioxide.

[0117] In one possible implementation, as shown in Figure 5 The method can further include:

[0118] Step S21, adjusting the feed liquid pressure in the membrane module and / or the flow rate of the feed liquid flowing through the membrane module, determining the feed liquid leakage resistance time length of the membrane module under different feed liquid pressures and / or different feed liquid flow rates;

[0119] Step S22, determining the relationship between the feed liquid pressure and / or the feed liquid flow rate and the feed liquid leakage resistance time length of the membrane module according to the feed liquid leakage resistance time length of the membrane module under different feed liquid pressures and / or different feed liquid flow rates.

[0120] The embodiment of the present disclosure determines the feed liquid leakage resistance time length of the membrane module under different feed liquid pressures and / or different feed liquid flow rates by adjusting the feed liquid pressure in the membrane module and / or the feed liquid flow rate flowing through the membrane module, and can accurately determine the relationship between the feed liquid pressure and / or the feed liquid flow rate and the feed liquid leakage resistance time length of the membrane module according to the feed liquid leakage resistance time length of the membrane module under different feed liquid pressures and / or different feed liquid flow rates.

[0121] By controlling the liquid and oxygen pressure flowing through the membrane module, different pressure differences on both sides of the hollow fiber membrane can be realized. By increasing the pressure on the liquid side, the transmembrane pressure difference (the difference between the pressure on the liquid side and the pressure on the gas side) is increased, which can accelerate the leakage process of the liquid. By testing the pressurized oxygenation membrane with known leakage performance, the variation law of the leakage time under different pressures is explored, and the correlation between the leakage time under pressurized conditions and the actual operation life is established, which improves the efficiency of predicting the life of the hollow fiber oxygenation membrane. For example, when the membrane oxygenator is in use, if the blood pressure and oxygen pressure in the target object change, the life of the current membrane oxygenator can be predicted according to the determined relationship between the feed liquid pressure and / or the feed liquid flow rate and the feed liquid leakage resistance time length of the membrane module, so that the membrane oxygenator can be replaced in advance before it is scrapped, ensuring the safety of the target object.

[0122] Of course, the embodiment of the present disclosure does not limit the specific form of the relationship between the feed liquid pressure and / or the feed liquid flow rate and the feed liquid leakage resistance time length of the membrane module, and the relationship can be in the form of a graph (such as a curve) or a prediction model, that is, the feed liquid pressure and / or the feed liquid flow rate is input into the prediction model, and the prediction model can output the predicted feed liquid leakage resistance time length of the membrane module.

[0123] In one possible implementation, as shown in FIG. 11, before the feed liquid in the feed liquid storage is circulated in the order of the output end of the feed liquid storage, the input end of the membrane module, the output end of the membrane module, and the input end of the feed liquid storage in step S11, the method can further include: Figure 5

[0124] Step S30, adjusting the carbon dioxide concentration and oxygen concentration in the feed liquid storage until the carbon dioxide concentration and oxygen concentration in the feed liquid storage reach a constant state.

[0125] ​For example, in this embodiment of the present disclosure, after the post-testing system is built, the carbon dioxide gas source can be turned on, the gas flow rate can be controlled, the feed liquid can be aerated, the dissolved oxygen concentration in the water can be reduced, and the dissolved carbon dioxide concentration can be increased until the carbon dioxide concentration and oxygen concentration in the feed liquid storage reach a constant state.

[0126] The following is an exemplary description of the testing method for the hollow fiber oxygenation membrane of the membrane oxygenator according to an embodiment of the present disclosure.

[0127] In one example, a hollow fiber oxygenation membrane (such as a commercial PP hollow fiber membrane (3M Oxyphan)) can first be encapsulated into a membrane module, with the effective area of ​​the oxygenation membrane in the membrane module controlled at 100 cm². 2 After the membrane module is fabricated, it is fixed in the corresponding position of the system (e.g., Figure 2 (As shown). Pure water is added to the feed liquid storage tank as the feed liquid. The carbon dioxide gas source is turned on, and the gas flow rate is controlled at approximately 200 mL / min using gas flow meter 3 to aerate the feed liquid, reducing the dissolved oxygen concentration and increasing the dissolved carbon dioxide concentration. After the dissolved carbon dioxide and oxygen concentrations in the tank reach a constant level, the circulation pump is turned on, and the feed liquid flow rate and pressure are controlled at 50 mL / min and 20 kPa respectively using the feed liquid flow detector and feed liquid pressure regulating valve. The oxygen gas source is turned on, and the gas flow rate is controlled at 100 mL / min, with the pressure controlled below 5 kPa. The concentration changes of dissolved oxygen and dissolved carbon dioxide are monitored using the first and second dissolved gas detectors.

[0128] Of course, the test can be repeated by replacing the feed solution with physiological saline, simulated blood, etc., or by changing the type of hollow fiber oxygenation membrane. The test results are shown in Table 1.

[0129] Table 1

[0130]

[0131] The publicly reported actual operating life of commercial PP membranes (3M Oxyphan) and PMP membranes (3M Oxyplus) is approximately 6-8 hours and 330 hours, respectively. As can be seen from the results of serial numbers 3 and 9 in Table 1, when the test method of the hollow fiber oxygenation membrane of the membrane oxygenator of the present disclosure embodiment is used and simulated blood is selected, the leakage time of PP and PMP membranes is close to the actual operating life, which shows the effectiveness of the test method of the hollow fiber oxygenation membrane of the membrane oxygenator of the present disclosure embodiment.

[0132] In addition, by increasing the transmembrane pressure, the leakage process of the PP and PMP membranes can be accelerated. As can be seen from the comparison of serial numbers 13-15, the service life of the self-made PP and PMP membranes measured by the accelerated leakage experiment is close to that of the commercial membranes, and the leakage time of the self-made PP and PMP membranes in the simulated blood is also close to that of the commercial membranes. When the service life measured by the accelerated leakage experiment is shorter, the leakage time of the self-made PP and PMP membranes in the simulated blood will also be shorter. The above shows that the accelerated leakage experiment provided by the test method of the hollow fiber oxygenation membrane of the membrane oxygenator according to the embodiments of the present disclosure can quickly and conveniently reflect the actual service life of the oxygenation membrane.

[0133] It can be understood that the above-mentioned various method embodiments mentioned in the present disclosure can be combined with each other to form combined embodiments without deviating from the principle logic. Limited by the length, the present disclosure will not be repeated. Those skilled in the art can understand that the specific execution order of each step in the above-mentioned method should be determined according to its function and possible internal logic.

[0134] In addition, the present disclosure also provides a test device, an electronic device, a computer readable storage medium, and a program for the hollow fiber oxygenation membrane of the membrane oxygenator, which can be used to implement any one of the test methods for the hollow fiber oxygenation membrane of the membrane oxygenator provided by the present disclosure. The corresponding technical solutions and descriptions are described in the method part and are not repeated.

[0135] Please refer to Figure 6 , Figure 6 A block diagram of a test device for the hollow fiber oxygenation membrane of the membrane oxygenator according to an embodiment of the present disclosure is shown.

[0136] As shown in Figure 6 , the device comprises:

[0137] A control module 10 is configured to control the circulation of the feed liquid in the feed liquid reservoir, the output end of the feed liquid reservoir, the input end of the membrane assembly, the output end of the membrane assembly, and the input end of the feed liquid reservoir in sequence, the membrane assembly is made of the hollow fiber oxygenation membrane to be tested, and the carbon dioxide concentration and the oxygen concentration of the feed liquid in the feed liquid reservoir are constant;

[0138] A first determination module 20 is configured to determine the mass transfer rate of oxygen and / or carbon dioxide of the membrane assembly at each time point;

[0139] A second determination module 30 is configured to determine that the feed liquid leakage phenomenon occurs in the membrane assembly and determine the feed liquid leakage resistance duration of the membrane assembly as the duration between the time when the feed liquid starts to flow and the time when the mass transfer rate of oxygen and / or carbon dioxide of the membrane assembly starts to decrease at a rate greater than the preset decreasing rate, in the case that the mass transfer rate of oxygen and / or carbon dioxide of the membrane assembly starts to decrease at a rate greater than the preset decreasing rate and the decreasing amplitude reaches or exceeds the preset amplitude.

[0140] The embodiments of the present disclosure control the feed liquid of the feed liquid reservoir to circulate in the order of the output end of the feed liquid reservoir, the input end of the membrane module, the output end of the membrane module, and the input end of the feed liquid reservoir, so as to keep the carbon dioxide concentration and the oxygen concentration of the feed liquid in the feed liquid reservoir constant, and determine the mass transfer rate of oxygen and / or carbon dioxide of the membrane module at each moment. In the case that the mass transfer rate of oxygen and / or carbon dioxide of the membrane module starts to decrease at a rate greater than a preset decrease rate and the decrease amplitude reaches or exceeds a preset amplitude, it is determined that the membrane module has a feed liquid leakage phenomenon, and the feed liquid leakage resistance duration of the membrane module is determined as the duration between the time when the feed liquid starts to flow and the time when the mass transfer rate starts to decrease at a rate greater than the preset decrease rate. The oxygenation performance of the oxygenation membrane can be fed back in real time, the feed liquid leakage resistance duration of the oxygenation membrane, i.e. the hollow fiber oxygenation membrane, can be accurately determined, and the precise prediction of the oxygenation performance and service life of the hollow fiber membrane can be realized.

[0141] In a possible implementation, the determination of the mass transfer rate of oxygen and / or carbon dioxide of the membrane module at each moment comprises:

[0142] The dissolved oxygen detector is used to obtain the dissolved oxygen content and / or the dissolved carbon dioxide content of the input end of the membrane module and the output end of the membrane module at each moment, the feed liquid flow detector is used to obtain the feed liquid flow rate flowing through the membrane module at each moment, the effective outer surface area of the hollow fiber oxygenation membrane to be tested is obtained, and the molar mass of oxygen and / or carbon dioxide is obtained;

[0143] The mass transfer rate of oxygen of the membrane module at each moment is determined according to the dissolved oxygen content of the input end of the membrane module and the output end of the membrane module at each moment, the feed liquid flow rate flowing through the membrane module at each moment, the effective outer surface area, and the molar mass of oxygen; and / or

[0144] The mass transfer rate of carbon dioxide of the membrane module at each moment is determined according to the dissolved carbon dioxide content of the input end of the membrane module and the output end of the membrane module at each moment, the feed liquid flow rate flowing through the membrane module at each moment, the effective outer surface area, and the molar mass of carbon dioxide.

[0145] In a possible implementation, the device further comprises:

[0146] The adjusting module is configured to adjust the feed liquid pressure in the membrane module and / or the feed liquid flow rate flowing through the membrane module, and determine the feed liquid leakage resistance duration of the membrane module under different feed liquid pressures and / or different feed liquid flow rates.

[0147] a relationship determining module configured to determine a relationship between the feed liquid pressure and / or the feed liquid flow rate and the feed liquid leakage resistance time length of the membrane module according to the feed liquid leakage resistance time length of the membrane module under different feed liquid pressures and / or different feed liquid flow rates.

[0148] In a possible implementation, before circulating the feed liquid in the feed liquid reservoir in the order of the output end of the feed liquid reservoir, the input end of the membrane module, the output end of the membrane module, and the input end of the feed liquid reservoir, the method further includes:

[0149] adjusting the carbon dioxide concentration and the oxygen concentration in the feed liquid reservoir until the carbon dioxide concentration and the oxygen concentration in the feed liquid reservoir reach a steady state.

[0150] In a possible implementation, the preset amplitude is 40% to 80%, and an oxygen source is arranged near the membrane module.

[0151] In a possible implementation, the feed liquid includes any one of pure water, physiological saline, blood, or simulated blood.

[0152] In some embodiments, the apparatus provided by the embodiments of the present disclosure has functions or includes modules that can be used to perform the methods described in the above method embodiments, and the specific implementation can be referred to the description of the above method embodiments. For brevity, details are not described here.

[0153] According to an aspect of the present disclosure, a test system for a hollow fiber oxygenation membrane of a membrane oxygenator is provided, the system comprising a feed liquid reservoir, a pump, a first dissolved gas detector, a second dissolved gas detector, a membrane module, a first feed liquid pressure detector, a second feed liquid pressure detector, a first gas pressure detector, a second gas pressure detector, a first gas flow detector, a second gas flow detector, a feed liquid flow rate detector, a feed liquid pressure regulating valve, a feed liquid flow rate regulating valve, and a controller, the membrane module being made of the hollow fiber oxygenation membrane to be tested, wherein:

[0154] the output end of the feed liquid reservoir, the pump, the membrane module, and the input end of the feed liquid reservoir are connected by a transmission pipeline,

[0155] the feed liquid reservoir is configured to store feed liquid,

[0156] the pump is configured to pump the feed liquid from the output end of the feed liquid reservoir to the input end of the membrane module,

[0157] the first dissolved gas detector is arranged at the input end of the membrane module and is configured to detect the dissolved oxygen content and / or the dissolved carbon dioxide content of the input end of the membrane module,

[0158] The second dissolved gas detector is arranged at the output end of the membrane module and is used to detect the dissolved oxygen content and / or the dissolved carbon dioxide content of the output end of the membrane module.

[0159] The first feed liquid pressure detector is arranged at the input end of the membrane module and is used to detect the feed liquid pressure of the input end of the membrane module.

[0160] The second feed liquid pressure detector is arranged at the output end of the membrane module and is used to detect the feed liquid pressure of the output end of the membrane module.

[0161] The first gas pressure detector is arranged at the input end of the membrane module and is used to detect the oxygen gas pressure of the input end of the membrane module.

[0162] The second gas pressure detector is arranged at the output end of the membrane module and is used to detect the oxygen gas pressure of the output end of the membrane module.

[0163] The first gas flow detector is arranged at the input end of the membrane module and is used to detect the oxygen gas flow of the input end of the membrane module.

[0164] The second gas flow detector is arranged at the output end of the membrane module and is used to detect the oxygen gas flow of the output end of the membrane module.

[0165] The feed liquid flow detector is arranged at the output end of the membrane module and is used to detect the feed liquid flow of the output end of the membrane module.

[0166] The feed liquid pressure regulating valve is arranged between the output end of the membrane module and the input end of the feed liquid reservoir and is used to regulate the feed liquid pressure of the feed liquid flowing through the membrane module.

[0167] The feed liquid flow regulating valve is arranged between the input end of the membrane module and the connection point of the pump and between the input end of the feed liquid reservoir and is used to regulate the feed liquid flow of the feed liquid flowing through the membrane module.

[0168] A controller is connected to the pump, the first dissolved gas detector, the second dissolved gas detector, the first feed liquid pressure detector, the second feed liquid pressure detector, the first gas pressure detector, the second gas pressure detector, the first gas flow detector, the second gas flow detector, the feed liquid flow detector, the feed liquid pressure regulating valve, and the feed liquid flow regulating valve, and the controller is used to:

[0169] The hollow fiber oxygenation membrane of the membrane oxygenator is tested by using the testing method.

[0170] In some embodiments, the system provided by the embodiments of the present disclosure has functions or includes modules that can be used to perform the methods described in the above method embodiments, and specific implementations can refer to the descriptions of the above method embodiments. For brevity, they will not be repeated here.

[0171] The embodiments of the present disclosure also provide a computer readable storage medium having stored thereon computer program instructions, which when executed by a processor, implement the above method. The computer readable storage medium can be a non-volatile computer readable storage medium.

[0172] The embodiments of the present disclosure also provide an electronic device, comprising: a processor; a memory for storing processor-executable instructions; wherein the processor is configured to invoke the instructions stored by the memory to execute the above method.

[0173] The embodiments of the present disclosure also provide a computer program product, comprising computer readable code, or a non-volatile computer readable storage medium carrying computer readable code, when the computer readable code is run in the processor of an electronic device, the processor in the electronic device executes the above method.

[0174] The electronic device can be provided as a terminal, a server or other forms of devices.

[0175] Please refer to Figure 7 , Figure 7 A block diagram of an electronic device according to an embodiment of the present disclosure is shown.

[0176] For example, the electronic device 800 can be a terminal such as a mobile phone, a computer, a digital broadcast terminal, a messaging device, a game console, a tablet device, a medical device, a fitness device, a personal digital assistant, etc.

[0177] Referring to Figure 7 , the electronic device 800 can include one or more of the following components: a processing component 802, a memory 804, a power supply component 806, a multimedia component 808, an audio component 810, an input / output (I / O) interface 812, a sensor component 814, and a communication component 816.

[0178] The processing component 802 usually controls overall operations of the electronic device 800, such as operations associated with display, phone calls, data communications, camera operations, and recording operations. The processing component 802 can include one or more processors 820 to execute instructions to complete all or part of the steps of the methods described above. In addition, the processing component 802 can include one or more modules to facilitate the interaction between the processing component 802 and other components. For example, the processing component 802 can include a multimedia module to facilitate the interaction between the multimedia component 808 and the processing component 802.

[0179] Memory 804 is configured to store various types of data to support operations of electronic device 800. Examples of such data include instructions for any application or methods operating on electronic device 800, contact data, phonebook data, messages, pictures, videos, and the like. Memory 804 can be implemented by any type of volatile or nonvolatile memory, or a combination thereof such as static random access memory (SRAM), electrically erasable programmable read only memory (EEPROM), erasable programmable read only memory (EPROM), programmable read only memory (PROM), read only memory (ROM), magnetic memory, flash memory, magnetic disks, or optical disks.

[0180] Power component 806 provides power to various components of electronic device 800. Power component 806 can include a power management system, one or more power supplies, and other components associated with generating, managing, and distributing power for electronic device 800.

[0181] Multimedia component 808 includes a screen providing an output interface between electronic device 800 and a user. In some embodiments, the screen can include a liquid crystal display (LCD) and a touch panel (TP). If the screen includes a touch panel, the screen can be implemented as a touch screen to receive an input signal from a user. The touch panel includes one or more touch sensors to sense a touch, a slide, and a gesture on the touch panel. The touch sensor can not only sense a boundary of a touching or a sliding action, but also detect duration and pressure related to the touching or sliding action. In some embodiments, multimedia component 808 includes a front camera and / or a back camera. The front and / or back camera can receive external multimedia data when electronic device 800 is in an operating mode, such as a photographing mode or a video mode. Each of the front and back camera can be a fixed optical lens system or have a focal length and optical zoom capability.

[0182] Audio component 810 is configured to output and / or input audio signals. For example, audio component 810 includes a microphone (MIC) configured to receive external audio signals when electronic device 800 is in an operating mode, such as a call mode, a recording mode, and a voice recognition mode. The received audio signals can be further stored in memory 804 or transmitted via communication component 816. In some embodiments, audio component 810 also includes a speaker for outputting audio signals.

[0183] I / O interface 812 provides an interface between processing component 802 and peripheral interface modules, which can be a keypad, a click wheel, buttons, and the like. The buttons can include, but are not limited to, a home button, a volume button, a start button, and a lock button.

[0184] The sensor component 814 includes one or more sensors for providing status assessments for various aspects of the electronic device 800. For example, the sensor component 814 can detect an open / closed position of the electronic device 800, relative positioning of components, such as a display and a keypad of the electronic device 800, a change in position of the electronic device 800 or a component of the electronic device 800, presence or absence of user contact with the electronic device 800, orientation or acceleration / deceleration / g-force and temperature of the electronic device 800. The sensor component 814 can include an optical sensor for detecting ambient light, a proximity sensor for detecting the presence of nearby objects without any physical touch, a motion sensor, a gyroscope sensor, a magnetometer sensor, a pressure sensor, or a temperature sensor.

[0185] The communication component 816 is configured to facilitate wired or wireless communication between the electronic device 800 and other devices. The electronic device 800 can access a wireless network based on a corresponding communication standard, such as wireless fidelity (WiFi), second generation (2G) or third generation (3G) mobile communication technology, or a combination thereof. In an example embodiment, the communication component 816 receives broadcast signals or broadcast-related information from an external broadcast management system via a broadcast channel. In an example embodiment, the communication component 816 further includes a near-field communication (NFC) module to facilitate short-range communication. For example, the NFC module can be implemented based on radio frequency identification (RFID) technology, infrared data association (IrDA) technology, ultra-wideband (UWB) technology, Bluetooth (BT) technology and other technology.

[0186] In an example embodiment, the electronic device 800 can be implemented using one or more application-specific integrated circuits (ASICs), digital signal processors (DSPs), digital signal processing devices (DSPDs), programmable logic devices (PLDs), field programmable gate arrays (FPGAs), controllers, micro-controllers, microprocessors or other electronic elements, to perform the above-described methods.

[0187] In an example embodiment, a non-transitory computer-readable storage medium, such as the memory 804 including computer program instructions, is also provided, which can be executed by the processor 820 of the electronic device 800 to perform the above-described methods.

[0188] Referring to Figure 8 , Figure 8A block diagram of an electronic device according to an embodiment of the disclosure is shown.

[0189] For example, the electronic device 1900 can be provided as a server. Referring to Figure 8 , the electronic device 1900 includes a processing component 1922, further including one or more processors, and memory resources represented by a memory 1932, for storing instructions executable by the processing component 1922, such as an application program. The application program stored in the memory 1932 can include one or more than one module each corresponding to a set of instructions. In addition, the processing component 1922 is configured to execute the instructions to perform the above method.

[0190] The electronic device 1900 can also include a power supply component 1926 configured to perform power management of the electronic device 1900, a wired or wireless network interface 1950 configured to connect the electronic device 1900 to a network, and an input / output (I / O) interface 1958. The electronic device 1900 can operate based on an operating system stored in the memory 1932, such as Microsoft Server Operating System (Windows Server TM ), Apple's graphical user interface-based operating system (Mac OSX TM ), multi-user multi-process computer operating system (Unix TM ), free and open source Unix-like operating system (Linux TM ), open source Unix-like operating system (FreeBSD TM ) or the like.

[0191] In an exemplary embodiment, a non-transitory computer readable storage medium, such as the memory 1932 including computer program instructions executable by the processing component 1922 of the electronic device 1900 to complete the above method is also provided.

[0192] The present disclosure can be a system, a method, and / or a computer program product. The computer program product can include a computer readable storage medium (or media) having computer readable program instructions thereon for causing a processor to carry out aspects of the present disclosure.

[0193] Computer readable storage media can be tangible storage media which can retain and store instructions for use by an instruction execution device. Computer readable storage media can be, for example, but is not limited to, an electronic storage device, a magnetic storage device, an optical storage device, an electromagnetic storage device, a semiconductor storage device, or any suitable combination of the foregoing. More specific examples (a non-exhaustive list) of computer readable storage media include the following: a portable computer diskette, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or Flash memory), a static random access memory (SRAM), a portable compact disc read-only memory (CD-ROM), a digital versatile disk (DVD), a memory stick, a floppy disk, a mechanically encoded device such as punch-cards or raised structures in a groove having instructions recorded thereon, and any suitable combination of the foregoing. A computer readable storage medium, as used herein, is not to be construed as being transitory signals per se, such as radio waves or other freely propagating electromagnetic waves, electromagnetic waves propagating through a waveguide or other transmission media (e.g., light pulses passing through a fiber-optic cable), or electrical signals transmitted through a wire.

[0194] Computer readable program instructions described herein can be downloaded to respective computing / processing devices from a computer readable storage medium or to an external computer or external storage device via a network, for example, the Internet, a local area network, a wide area network and / or a wireless network. The network can comprise copper transmission cables, optical transmission fibers, wireless transmission, routers, firewalls, switches, gateway computers and / or edge servers. A network adapter card or network interface in each computing / processing device receives computer readable program instructions from the network and forwards the computer readable program instructions for storage in a computer readable storage medium within the respective computing / processing device.

[0195] Computer readable program instructions for carrying out operations of the present disclosure can be assembler instructions, instruction-set-architecture (ISA) instructions, machine instructions, machine dependent instructions, microcode, firmware instructions, state-setting data, or either source code or object code written in any combination of one or more programming languages, including an object oriented programming language such as Smalltalk, C++ or the like and conventional procedural programming languages, such as the "C" programming language or similar programming languages. The computer readable program instructions can execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server. In the latter scenario, the remote computer can be connected to the user's computer through any type of network, including a local area network (LAN) or a wide area network (WAN), or the connection can be made to an external computer (for example, through the Internet using an Internet Service Provider). In some embodiments, electronic circuitry including, for example, programmable logic circuitry, field-programmable gate array (FPGA), or programmable logic array (PLA) can execute the computer readable program instructions by utilizing state information of the computer readable program instructions to personalize the electronic circuitry, in order to perform aspects of the present disclosure.

[0196] The computer readable program instructions can also be loaded onto a computer, other programmable data processing apparatus, or other device to cause a series of operational steps to be performed on the computer, other programmable apparatus or other device to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide processes for implementing the functions / acts specified in the flowchart and / or block diagram block or blocks.

[0197] These computer readable program instructions can be provided to a processor of a general purpose computer, special purpose computer, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the functions / acts specified in the flowchart and / or block diagram block or blocks. These computer readable program instructions can also be stored in a computer readable storage medium that can include random access memory (RAM), read only memory (ROM), electrically erasable programmable read only memory (EEPROM), flash memory or other data storage device. When the computer readable program instructions are loaded into the computer and other programmable data processing apparatus, a series of operational steps are implemented that provide processes such that the computer or other programmable apparatus provide processes for implementing the functions / acts specified in the flowchart and / or block diagram block or blocks.

[0198] The computer readable program instructions can also be loaded onto a computer, other programmable data processing apparatus, or other device to cause a series of operational steps to be performed on the computer, other programmable data processing apparatus or other device to produce a computer implemented process such that the instructions which execute on the computer, other programmable data processing apparatus, or other device implement the functions / acts specified in the flowchart and / or block diagram block or blocks.

[0199] The flow diagrams and the block diagrams in the accompanying drawings illustrate the architecture, functionality, and operation of possible implementations of systems, methods and computer program products according to various embodiments of the present disclosure. In this regard, each block in the flow diagrams and the block diagrams can represent a module, segment, or portion of instructions, which comprises one or more executable instructions for implementing the specified logic functions. In some alternative implementations, the functions noted in the blocks can occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks can sometimes be executed in the reverse order, depending upon the functionality involved. It will also be noted that each block of the block diagrams and / or flowchart illustrations, and combinations thereof, can be implemented by special purpose hardware-based systems that perform the specified functions or acts, or combinations of special purpose hardware and

[0200] The computer program product can be embodied by hardware, software or a combination thereof. In an optional embodiment, the computer program product is embodied by a computer storage medium, and in another optional embodiment, the computer program product is embodied by a software product, such as a software development kit (SDK) or the like.

[0201] The above description has described various embodiments of the present disclosure, and the above description is exemplary, not exhaustive, and is not limited to the disclosed embodiments. Many modifications and changes are obvious to those skilled in the art without departing from the scope and spirit of the described embodiments. The selection of the terms used herein is intended to best explain the principles, practical application or improvement of the technology in the market of the embodiments, or to enable other ordinary skilled in the art to understand the embodiments disclosed herein.

Claims

1. A method of testing a hollow fiber oxygenation membrane of a membrane oxygenator, characterized by, The method comprises: controlling the flow of the liquid in the liquid storage in a sequence of the output end of the liquid storage, the input end of the membrane assembly, the output end of the membrane assembly, and the input end of the liquid storage, the membrane assembly being made of a hollow fiber oxygenation membrane to be tested, the carbon dioxide concentration and the oxygen concentration of the liquid in the liquid storage being constant; determining the mass transfer rate of oxygen and / or carbon dioxide of the membrane assembly at each time point; in the case that the mass transfer rate of oxygen and / or carbon dioxide of the membrane assembly starts to decrease at a rate greater than a preset decreasing rate and the decreasing amplitude reaches or exceeds a preset amplitude, determining that the membrane assembly has a liquid leakage phenomenon, and determining the liquid leakage resistance duration of the membrane assembly as the duration between the time when the liquid starts to flow and the time when the mass transfer rate starts to decrease at a rate greater than the preset decreasing rate, the determination of the mass transfer rate of oxygen and / or carbon dioxide of the membrane assembly at each time point comprises: obtaining the dissolved oxygen content and / or the dissolved carbon dioxide content of the input end of the membrane assembly and the output end of the membrane assembly at each time point, obtaining the liquid flow rate flowing through the membrane assembly at each time point, the effective outer surface area of the hollow fiber oxygenation membrane to be tested, and the molar mass of oxygen and / or carbon dioxide; determining the mass transfer rate of oxygen of the membrane assembly at each time point according to the dissolved oxygen content of the input end of the membrane assembly and the output end of the membrane assembly at each time point, the liquid flow rate flowing through the membrane assembly at each time point, the effective outer surface area, and the molar mass of oxygen; and / or determining the mass transfer rate of carbon dioxide of the membrane assembly at each time point according to the dissolved carbon dioxide content of the input end of the membrane assembly and the output end of the membrane assembly at each time point, the liquid flow rate flowing through the membrane assembly at each time point, the effective outer surface area, and the molar mass of carbon dioxide.

2. The method of claim 1, wherein, The method further comprises: adjusting the liquid pressure in the membrane assembly and / or the liquid flow rate flowing through the membrane assembly, and determining the liquid leakage resistance duration of the membrane assembly under different liquid pressures and / or different liquid flow rates; determining the relationship between the liquid pressure and / or the liquid flow rate and the liquid leakage resistance duration of the membrane assembly according to the liquid leakage resistance duration of the membrane assembly under different liquid pressures and / or different liquid flow rates.

3. The method of claim 1, wherein, Before controlling the flow of the liquid in the liquid storage in a sequence of the output end of the liquid storage, the input end of the membrane assembly, the output end of the membrane assembly, and the input end of the liquid storage, the method further comprises: adjusting the carbon dioxide concentration and the oxygen concentration in the liquid storage until the carbon dioxide concentration and the oxygen concentration in the liquid storage reach a constant state.

4. The method of claim 1, wherein, The preset amplitude is 40% to 80%, and an oxygen source is arranged near the membrane assembly.

5. The method of claim 1, wherein, The liquid comprises any one of pure water, physiological saline, blood, or simulated blood.

6. A testing device for hollow fiber oxygenation membranes of a membrane oxygenator, characterized by The device comprises: a control module configured to control circulation of the feed solution in the feed solution reservoir, the input end of the membrane module, the output end of the membrane module, and the input end of the feed solution reservoir in sequence, the membrane module being made of a hollow fiber oxygenation membrane to be tested, and the feed solution in the feed solution reservoir having a constant carbon dioxide concentration and a constant oxygen concentration; a first determination module configured to determine a mass transfer rate of oxygen and / or carbon dioxide of the membrane module at each time point; a second determination module configured to determine that the membrane module has a feed solution leakage phenomenon and determine a feed solution leakage resistance duration of the membrane module as a time duration between a time when the feed solution starts to flow and a time when the mass transfer rate of oxygen and / or carbon dioxide of the membrane module starts to decrease at a rate greater than a preset decreasing rate, in a case that the mass transfer rate of oxygen and / or carbon dioxide of the membrane module starts to decrease at a rate greater than the preset decreasing rate and a decreasing amplitude reaches or exceeds a preset amplitude, the determination of the mass transfer rate of oxygen and / or carbon dioxide of the membrane module at each time point comprises: obtaining dissolved oxygen content and / or dissolved carbon dioxide content of the input end of the membrane module and the output end of the membrane module at each time point by using a dissolved oxygen detector, obtaining a feed solution flow rate at each time point by using a feed solution flow rate detector, obtaining an effective outer surface area of the hollow fiber oxygenation membrane to be tested, and obtaining a molar mass of oxygen and / or carbon dioxide; determining the mass transfer rate of oxygen of the membrane module at each time point according to the dissolved oxygen content of the input end of the membrane module and the output end of the membrane module at each time point, the feed solution flow rate at each time point, the effective outer surface area, and the molar mass of oxygen; and / or determining the mass transfer rate of carbon dioxide of the membrane module at each time point according to the dissolved carbon dioxide content of the input end of the membrane module and the output end of the membrane module at each time point, the feed solution flow rate at each time point, the effective outer surface area, and the molar mass of carbon dioxide.

7. The apparatus of claim 6, wherein, the device further comprises: an adjustment module configured to adjust a feed solution pressure in the membrane module and / or a feed solution flow rate through the membrane module, and determine the feed solution leakage resistance duration of the membrane module under different feed solution pressures and / or different feed solution flow rates; a relationship determination module configured to determine a relationship between the feed solution pressure and / or the feed solution flow rate and the feed solution leakage resistance duration of the membrane module according to the feed solution leakage resistance duration of the membrane module under different feed solution pressures and / or different feed solution flow rates.

8. A test system for hollow fiber oxygenation membranes of a membrane oxygenator, characterized by, the system comprises a feed solution reservoir, a pump, a first dissolved gas detector, a second dissolved gas detector, a membrane module, a first feed solution pressure detector, a second feed solution pressure detector, a first gas pressure detector, a second gas pressure detector, a first gas flow detector, a second gas flow detector, a feed solution flow rate detector, a feed solution pressure adjusting valve, a feed solution flow rate adjusting valve, and a controller, the membrane module being made of a hollow fiber oxygenation membrane to be tested, wherein: the output end of the feed solution reservoir, the pump, the membrane module, and the input end of the feed solution reservoir are connected by a transmission pipeline, the feed solution reservoir is configured to store a feed solution, the pump, for pumping feed liquid from an output end of the feed liquid reservoir to an input end of the membrane module, the first dissolved gas detector, disposed at the input end of the membrane module, for detecting dissolved oxygen content and / or dissolved carbon dioxide content at the input end of the membrane module, the second dissolved gas detector, disposed at the output end of the membrane module, for detecting dissolved oxygen content and / or dissolved carbon dioxide content at the output end of the membrane module, the first feed liquid pressure detector, disposed at the input end of the membrane module, for detecting feed liquid pressure at the input end of the membrane module, the second feed liquid pressure detector, disposed at the output end of the membrane module, for detecting feed liquid pressure at the output end of the membrane module, the first gas pressure detector, disposed at the input end of the membrane module, for detecting oxygen gas pressure at the input end of the membrane module, the second gas pressure detector, disposed at the output end of the membrane module, for detecting oxygen gas pressure at the output end of the membrane module, the first gas flow detector, disposed at the input end of the membrane module, for detecting oxygen gas flow at the input end of the membrane module, the second gas flow detector, disposed at the output end of the membrane module, for detecting oxygen gas flow at the output end of the membrane module, the feed liquid flow detector, disposed at the output end of the membrane module, for detecting feed liquid flow at the output end of the membrane module, the feed liquid pressure regulating valve, disposed between the output end of the membrane module and the input end of the feed liquid reservoir, for regulating feed liquid pressure of feed liquid flowing through the membrane module, the feed liquid flow regulating valve, disposed between the input end of the membrane module and the connection point of the pump, and between the input end of the feed liquid reservoir, for regulating feed liquid flow of feed liquid flowing through the membrane module, a controller, connected to the pump, the first dissolved gas detector, the second dissolved gas detector, the first feed liquid pressure detector, the second feed liquid pressure detector, the first gas pressure detector, the second gas pressure detector, the first gas flow detector, the second gas flow detector, the feed liquid flow detector, the feed liquid pressure regulating valve, the feed liquid flow regulating valve, the controller being configured to: perform the test method of the hollow fiber oxygenation membrane of the membrane oxygenator as claimed in any one of claims 1 to 5.

9. An electronic device, comprising: comprise: a processor; a memory for storing processor-executable instructions; wherein the processor is configured to invoke the instructions stored in the memory to perform the test method of the hollow fiber oxygenation membrane of the membrane oxygenator as claimed in any one of claims 1 to 5.

10. A computer-readable storage medium having stored thereon computer program instructions, wherein, the computer program instructions, when executed by the processor, implement the test method of the hollow fiber oxygenation membrane of the membrane oxygenator as claimed in any one of claims 1 to 5.

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