A method and apparatus for determining mean arterial pressure, and an electronic device

Abstract

The application discloses a kind of determination method, device and electronic equipment of mean arterial pressure, the method includes: obtaining pressure measurement data, the pressure measurement data includes multiple continuous blood pressure measurement values;Periodic characteristic detection is carried out to pressure measurement data, and the periodic characteristic detection result is obtained, wherein, periodic characteristic detection result includes periodic characteristic and periodic time, periodic time is the time when periodic characteristic appears, the time difference between adjacent two periodic times corresponds the length of time of one cardiac cycle, and periodic characteristic is the characteristic value that appears only once in one cardiac cycle;The target time period corresponding to the time to be measured is determined according to periodic characteristic detection result;Blood pressure measurement value in target time period is screened from pressure measurement data;The mean arterial pressure corresponding to the time to be measured is determined according to blood pressure measurement value in target time period.The mean arterial pressure determined by the above method is high in accuracy and strong in reason.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of medical devices, and in particular to a mean arterial pressure determination method and device and electronic device. BACKGROUND

[0002] The mean value of arterial blood pressure in a cardiac cycle is called mean arterial pressure (MAP). MAP represents the blood perfusion pressure of organs (tissues) and is an important vital sign in human health monitoring. In the prior art, continuous multiple blood pressure instantaneous values in the artery are obtained in the form of arterial cannulation, and then systolic arterial pressure (SAP) and diastolic arterial pressure (DAP) are determined from the continuous multiple blood pressure instantaneous values by a medical device or medical personnel, and then the mean arterial pressure is estimated according to the systolic pressure and diastolic pressure. Since the blood pressure instantaneous values other than SAP and DAP in the cardiac cycle are discarded, the accuracy of the calculated MAP value is low, and the blood perfusion pressure of organs (tissues) cannot be well reflected, so that the human health state cannot be accurately monitored. SUMMARY

[0003] The present application provides a mean arterial pressure determination method, a mean arterial pressure determination device, an electronic device, a computer readable storage medium, a pressure measurement system, a pressure gradient sensing system, a blood pump system, and an ablation system, which can obtain accurate mean arterial pressure and accurately monitor the health state of a living body.

[0004] In a first aspect, the present application provides a mean arterial pressure determination method, comprising:

[0005] obtaining pressure measurement data, the pressure measurement data comprising multiple continuous blood pressure measurement values;

[0006] performing cycle feature detection on the pressure measurement data to obtain a cycle feature detection result, wherein the cycle feature detection result comprises a cycle feature and a cycle time, the cycle time is the time when the cycle feature appears, the time difference between adjacent two cycle times corresponds to the duration of a cardiac cycle, and the cycle feature is a characteristic value that appears only once in a cardiac cycle;

[0007] determining a target time period corresponding to the to-be-measured time according to the cycle feature detection result;

[0008] screening blood pressure measurement values in the target time period from the pressure measurement data;

[0009] determine the mean arterial pressure corresponding to the to-be-detected time according to blood pressure measurement values in the target time period.

[0010] As an optional implementation, in the first aspect of the present application, the determination of the target time period corresponding to the to-be-detected time according to the periodic feature detection result comprises:

[0011] determine a time parameter corresponding to the to-be-detected time according to the periodic feature detection result and a preset periodic number N, wherein the time parameter comprises N+1 periodic time points closest to the to-be-detected time, N is a natural number greater than or equal to 0, and the greater N is, the farther the periodic time points corresponding to N are from the to-be-detected time;

[0012] determine the target time period corresponding to the to-be-detected time according to the time parameter.

[0013] As an optional implementation, in the first aspect of the present application, the determination of the target time period corresponding to the to-be-detected time according to the time parameter comprises:

[0014] if the to-be-detected time is a periodic time point, determine a time period between the Nth periodic time point in the time parameter and the to-be-detected time as the target time period corresponding to the to-be-detected time;

[0015] if the to-be-detected time is not a periodic time point, calculate a first time difference between the to-be-detected time and the first periodic time point in the time parameter, and a second time difference between the first periodic time point in the time parameter and the second periodic time point in the time parameter;

[0016] determine whether the first time difference is less than the second time difference;

[0017] if the first time difference is greater than or equal to the second time difference, determine a time period between the Nth periodic time point in the time parameter and the to-be-detected time as the target time period corresponding to the to-be-detected time;

[0018] if the first time difference is less than the second time difference, delay the N+1th periodic time point in the time parameter by a fill-in duration to obtain a first time point, and determine a time period between the first time point and the to-be-detected time as the target time period corresponding to the to-be-detected time; wherein the fill-in duration is calculated according to the following formula: wherein Δt is the fill-in duration, t1 is the first periodic time point in the time parameter, t2 is the second periodic time point in the time parameter, t n+1 is the N+1th periodic time point in the time parameter, t n is the Nth periodic time point in the time parameter, and ti for the to-be-detected time point.

[0019] As an optional implementation, in the first aspect of the present application, the pressure measurement data comprises a plurality of continuous blood pressure measurement values from the same measurement position.

[0020] The blood pressure measurement value in the target time period is a plurality of blood pressure measurement values in the target time period.

[0021] The determination of the mean arterial pressure corresponding to the to-be-detected time point according to the blood pressure measurement value in the target time period comprises:

[0022] Calculating the mean of the plurality of blood pressure measurement values in the target time period, and determining the mean of the plurality of blood pressure measurement values in the target time period as the mean arterial pressure.

[0023] As an optional implementation, in the first aspect of the present application, the periodic feature is diastolic pressure, systolic pressure, or dicrotic notch.

[0024] As an optional implementation, in the first aspect of the present application, the pressure measurement data comprises a plurality of continuous first blood pressure measurement values positioned on the distal side of the target object, and a plurality of continuous second blood pressure measurement values positioned on the proximal side of the target object.

[0025] The blood pressure measurement value in the target time period comprises a plurality of first blood pressure measurement values in the target time period and a plurality of second blood pressure measurement values in the target time period.

[0026] The determination of the mean arterial pressure corresponding to the to-be-detected time point according to the blood pressure measurement value in the target time period comprises:

[0027] Calculating the mean of the plurality of first blood pressure measurement values in the target time period to obtain the first mean arterial pressure corresponding to the to-be-detected time point.

[0028] Calculating the mean of the plurality of second blood pressure measurement values in the target time period to obtain the second mean arterial pressure corresponding to the to-be-detected time point.

[0029] The method further comprises:

[0030] Determining target information according to the first mean arterial pressure and the second mean arterial pressure.

[0031] As an optional implementation, in the first aspect of the present application, the target information is blood flow reserve fraction, and the target object is a blood pressure measurement member.

[0032] The determination of target information according to the first mean arterial pressure and the second mean arterial pressure comprises:

[0033] calculating a ratio of the first mean arterial pressure to the second mean arterial pressure, and determining the ratio of the first mean arterial pressure to the second mean arterial pressure as the blood flow reserve fraction.

[0034] As an optional implementation, in the first aspect of the present application, the target information is a position condition of a blood pump, and the target object is a pump shell of the blood pump.

[0035] The determining of the target information according to the first mean arterial pressure and the second mean arterial pressure comprises:

[0036] calculating a ratio and / or difference of the second mean arterial pressure to the first mean arterial pressure;

[0037] determining the position condition of the blood pump according to the ratio and / or difference of the second mean arterial pressure to the first mean arterial pressure.

[0038] As an optional implementation, in the first aspect of the present application, the target information is a radio frequency ablation degree, and the target object is an ablation needle or a guide sheath for carrying the ablation needle.

[0039] The determining of the target information according to the first mean arterial pressure and the second mean arterial pressure comprises:

[0040] calculating a ratio and / or difference of the first mean arterial pressure to the second mean arterial pressure, and determining the radio frequency ablation degree according to the ratio and / or difference of the first mean arterial pressure to the second mean arterial pressure.

[0041] In a second aspect, the present application provides a device for calculating mean arterial pressure, comprising:

[0042] an acquisition module configured to acquire pressure measurement data, the pressure measurement data comprising a plurality of continuous blood pressure measurement values;

[0043] a detection module configured to perform periodic feature detection on the pressure measurement data to obtain a periodic feature detection result, wherein the periodic feature detection result comprises a periodic feature and a periodic time point, the periodic time point being a time point at which the periodic feature appears, a time difference between two adjacent periodic time points corresponding to a length of a cardiac cycle, and the periodic feature being a feature value appearing only once in a cardiac cycle;

[0044] a first determination module configured to determine a target time period corresponding to a to-be-measured time point according to the periodic feature detection result;

[0045] a screening module configured to screen blood pressure measurement values in the target time period from the pressure measurement data;

[0046] A second determining module is configured to determine the mean arterial pressure corresponding to the to-be-detected time point according to the blood pressure measurement value in the target time period.

[0047] In a third aspect, the present application provides an electronic device, which comprises:

[0048] a memory storing executable program code;

[0049] a processor coupled to the memory;

[0050] The processor invokes the executable program code stored in the memory to execute the mean arterial pressure determination method disclosed in the first aspect of the present application.

[0051] In a fourth aspect, the present application provides a computer readable storage medium, which stores executable program code, and the executable program code, when invoked, is configured to execute the mean arterial pressure determination method disclosed in the first aspect of the present application.

[0052] In a fifth aspect, the present application provides a pressure measurement system, which comprises a pressure measurement device and a processing device, wherein:

[0053] The pressure measurement device comprises:

[0054] an elongated body;

[0055] a pressure measurement unit arranged on the elongated body and configured to acquire pressure measurement data;

[0056] The processing device comprises a communication interface, a memory and a processor.

[0057] The communication interface is configured to realize data transmission between the processing device and the pressure measurement device.

[0058] The memory is configured to store executable program code.

[0059] The processor is configured to invoke the executable program code, and when the executable program code is executed, the mean arterial pressure determination method disclosed in the first aspect of the present application is realized.

[0060] In a sixth aspect, the present application provides a pressure gradient sensing system, which comprises a pressure sensing device and a processing device.

[0061] The pressure sensing device comprises:

[0062] an elongated body;

[0063] A pressure measuring unit is arranged on the elongated body to obtain pressure measurement data, wherein the pressure measuring unit comprises a first pressure sensor and a second pressure sensor, the first pressure sensor is arranged at a distal side and spaced apart from the second pressure sensor;

[0064] The processing device comprises a communication interface, a memory and a processor;

[0065] The communication interface is configured to realize data transmission between the processing device and the pressure sensing device;

[0066] The memory is configured to store executable program codes;

[0067] The processor is configured to call the executable program codes, and when the executable program codes are executed, the method for determining the target information is realized.

[0068] In a seventh aspect, the present application provides a blood pump system, comprising a blood pump assembly and a processing device;

[0069] The blood pump assembly comprises:

[0070] A pump housing;

[0071] A rotor arranged in the pump housing;

[0072] A pressure measuring unit arranged on the pump housing, wherein the pressure measuring unit is configured to obtain pressure measurement data, and the pressure measuring unit comprises a first pressure sensor and a second pressure sensor, the first pressure sensor is arranged at a distal side and spaced apart from the second pressure sensor;

[0073] The processing device comprises a communication interface, a memory and a processor;

[0074] The communication interface is configured to realize data transmission between the processing device and the blood pump assembly;

[0075] The memory is configured to store executable program codes;

[0076] The processor is configured to call the executable program codes, and when the executable program codes are executed, the method for determining the target information is realized.

[0077] In an eighth aspect, the present application provides an ablation system, comprising an ablation device and a processing device;

[0078] The ablation device comprises:

[0079] An ablation needle capable of moving axially in the guide sheath;

[0080] A pressure measuring unit arranged on the guide sheath and / or the ablation needle, wherein the pressure measuring unit is configured to acquire pressure measurement data, and the pressure measuring unit comprises a first pressure sensor and a second pressure sensor, the first pressure sensor is arranged at a distal side and spaced apart from the second pressure sensor;

[0081] The processing device comprises a communication interface, a memory and a processor;

[0082] The communication interface is configured to realize data transmission between the processing device and the ablation device;

[0083] The memory is configured to store executable program codes;

[0084] The processor is configured to call the executable program codes, and when the executable program codes are executed, the target information is the radiofrequency ablation degree, and the method for determining the target information is realized.

[0085] Compared with the prior art, the embodiments of the present application have the following beneficial effects:

[0086] In the embodiments of the present application, a plurality of continuous blood pressure measurement values are obtained, and a periodic feature is detected based on the plurality of continuous blood pressure measurement values. The target time period corresponding to the to-be-measured moment is determined according to the detection result of the periodic feature, and the mean arterial pressure is determined according to the blood pressure measurement values collected in the target time period. It can be seen that, when the mean arterial pressure is determined, the present application can consider other blood pressure instantaneous values in addition to diastolic pressure and systolic pressure in a cardiac cycle. At the same time, the time range for determining the mean arterial pressure of the to-be-measured moment takes into account the influence of the cardiac cycle, thereby increasing the accuracy and rationality of the mean arterial pressure measurement, realizing accurate monitoring of the blood perfusion pressure of the organism organ (tissue), and having high safety and strong reliability. BRIEF DESCRIPTION OF DRAWINGS

[0087] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed in the embodiment description will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor.

[0088] Figure 1 is a flowchart of a mean arterial pressure determination method disclosed by the embodiments of the present application;

[0089] Figure 2 is a flowchart of another mean arterial pressure determination method disclosed by the embodiments of the present application;

[0090] Figure 3a is a schematic diagram of determining a target time period according to an embodiment of the present application;

[0091] Figure 3b is another schematic diagram of determining a target time period according to an embodiment of the present application;

[0092] Figure 3c is still another schematic diagram of determining a target time period according to an embodiment of the present application;

[0093] Figure 4 is a flowchart of a method for determining mean arterial pressure according to an embodiment of the present application;

[0094] Figure 5 is a structural diagram of a device for determining mean arterial pressure according to an embodiment of the present application;

[0095] Figure 6 is another structural diagram of a device for determining mean arterial pressure according to an embodiment of the present application;

[0096] Figure 7 is still another structural diagram of a device for determining mean arterial pressure according to an embodiment of the present application;

[0097] Figure 8 is a structural diagram of an electronic device according to an embodiment of the present application;

[0098] Figure 9 is a structural diagram of a pressure measurement system according to an embodiment of the present application;

[0099] Figure 10 is a structural diagram of a pressure gradient sensing system according to an embodiment of the present application;

[0100] Figure 11 is a structural diagram of a blood pump system according to an embodiment of the present application;

[0101] Figure 12 is a structural diagram of a radio frequency ablation system according to an embodiment of the present application;

[0102] Figure 13 is another structural diagram of a radio frequency ablation system according to an embodiment of the present application. DETAILED DESCRIPTION

[0103] In the following, the technical solutions in the embodiments of the present application will be described clearly and completely with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments in the present application, all the other embodiments obtained by a person of ordinary skill in the art without creative work fall within the protection scope of the present application.

[0104] The terms "first", "second", and the like in the description and claims of the present application and the above drawings are used to distinguish different objects, rather than to describe a particular order. In addition, the terms "comprise" and "have" and any variations thereof are intended to cover non-exclusive inclusion. For example, a process, method, device, product or end comprising a series of steps or units is not limited to the listed steps or units, but can optionally further comprise steps or units not listed, or can optionally further comprise other steps or units inherent to the process, method, product or end.

[0105] In this document, the term "embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the application. The appearance of this phrase in various places in the specification does not necessarily all refer to the same embodiment, nor is it necessarily mutually exclusive of other embodiments. It will be explicitly understood by a person of ordinary skill in the art that the embodiments described herein can be combined with other embodiments.

[0106] Definition: In the field of interventional medical devices, the proximal end refers to the end closer to the operator, and the distal end refers to the end farther from the operator, and the axial direction refers to the direction parallel to the center line connecting the distal end center and the proximal end center of the medical device. The above definitions are only for convenience of expression, and cannot be understood as a limitation of the present application.

[0107] It should be noted that "first", "second", and the like in the name of the present application are only used for naming distinction and identification, and do not limit the quantity, order, etc. of the present application.

[0108] Embodiment one

[0109] Please refer to Figure 1 , Figure 1 is a flowchart of a method for determining mean arterial pressure according to an embodiment of the present application. Wherein, Figure 1 The described method for determining mean arterial pressure can be applied in an electronic device, such as a controller, a processor, etc. connected with a medical device, of course, the electronic device can also be a terminal device or a server, and the embodiments of the present application are not limited. As Figure 1 The method for determining mean arterial pressure can include the following operations, as shown in the figure.

[0110] S101, acquiring pressure measurement data, the pressure measurement data comprising a plurality of continuous blood pressure measurement values.

[0111] In the embodiments of the present application, the execution subject electronic device can continuously receive the continuous blood pressure measurement values measured by the pressure measuring unit (such as a pressure sensor), and save the received blood pressure measurement values, wherein the blood pressure measurement values can be recorded in the form of numbers or a tracing graph. For example, the execution subject electronic device can be a processing device in a pressure measurement system, a processing device in a pressure gradient sensing system, a processing device in a blood pump system, a processing device in an ablation system, etc. Optionally, the pressure measurement data comprises a plurality of continuous blood pressure measurement values from the same measurement position. Further optionally, the plurality of continuous blood pressure measurement values in the pressure measurement data can be measured and recorded by an invasive blood pressure measurement method. The invasive blood pressure measurement method generally measures the blood pressure at the target measurement position of the artery through an interventional medical instrument with pressure measuring function (such as a catheter, a guide wire, a blood pump, an ablation device (such as an ablation needle and / or a guide sheath carrying an ablation needle), etc.) entering the position.

[0112] S102, performing periodic feature detection on the pressure measurement data to obtain a periodic feature detection result, wherein the periodic feature detection result comprises a periodic feature and a periodic time point, the periodic time point is the time point when the periodic feature appears, the time difference between two adjacent periodic time points corresponds to the duration of one cardiac cycle, and the periodic feature is a feature value that appears only once in one cardiac cycle.

[0113] In the embodiments of the present application, the electronic device performs periodic feature detection on each blood pressure measurement value in the pressure measurement data in real time, and records the detection result. For example, the blood pressure measurement value with the periodic feature is marked or saved in the related storage unit. The periodic feature can be, for example, diastolic pressure (DAP), systolic pressure (SAP), dicrotic notch (DN), or other features, which can be selected according to the needs of actual application. It can be understood that, since diastolic pressure, systolic pressure and dicrotic notch appear only once in one cardiac cycle, the time difference between two adjacent diastolic pressures, systolic pressures and dicrotic notches corresponds to the duration of one cardiac cycle, that is, the duration of the occurrence of two adjacent periodic time points corresponds to the duration of one cardiac cycle. In the embodiments of the present application, diastolic pressure is taken as the periodic feature. It can also be understood that, since diastolic pressure has a stable minimum lower boundary during the cardiac cycle, selecting diastolic pressure as the start and end marker of the cardiac cycle helps to reduce the occurrence of false detection, thereby increasing the detection accuracy.

[0114] In the embodiment of the present application, specifically, the diastolic pressure or systolic pressure of each cardiac cycle can be detected by difference threshold method, local extremum method or other methods, and the dicrotic notch can be detected by adopting logarithmic polar coordinate distribution model. Taking the detection of diastolic pressure as an example, the general process is as follows:

[0115] First, the difference of the plurality of blood pressure measurement values D is obtained to obtain diff_D. The calculation method of the difference can adopt the method of subtracting the value of the last sampling point from the value of the current sampling point, diff_D[i]=D[i]-D[i-1]. Other methods can also be adopted, for example, the formula diff_D[i]=(D[i]+2*D[i-1]-2*D[i-3]-D[i-4]) / 8.

[0116] When the value of the difference signal diff_D changes from negative to positive, or the value of diff_D[i] is 0 and diff_D[i-1]<0 and diff_D[i+1]>0, it indicates that the blood pressure measurement value D has a local minimum point.

[0117] The local extremum method directly selects the D value corresponding to the minimum point as the diastolic pressure. The difference threshold method further judges on this basis, and if the minimum point is less than a pre-set threshold v, it is considered that the minimum point is the diastolic pressure. These detection methods can also have many improvements to improve the accuracy of detection (reduce false positives and false negatives), for example: the threshold v of the difference threshold method can be adaptively adjusted according to the change of the blood pressure value. The above methods are common detection methods in the art, and the present application will not be described in detail.

[0118] S103, determining a target time period corresponding to the to-be-detected time according to the period characteristic detection result.

[0119] In the embodiment of the present application, after the period characteristic detection result of the pressure measurement data is detected, the target time period corresponding to the to-be-detected time can be determined by the pressure measurement data of the to-be-detected time. The to-be-detected time can be the current time or the historical time, which can be set according to the actual application. Preferably, the to-be-detected time is the current time, so as to realize real-time and continuous acquisition of the mean arterial pressure, and avoid delay in detecting the mean arterial pressure.

[0120] In the embodiment of the present application, refer to Figure 2 , Figure 2 is a flowchart of another method for determining mean arterial pressure disclosed by the embodiment of the present application. As shown in Figure 2 , step S103, determining a target time period corresponding to the to-be-detected time according to the period characteristic detection result, comprises:

[0121] S1031, determining a time parameter corresponding to the to-be-measured time according to the period feature detection result and a preset number N of periods, wherein the time parameter comprises N+1 period times closest to the to-be-measured time, N is a natural number greater than or equal to 0, and the greater N is, the farther the period times corresponding to N are from the to-be-measured time.

[0122] In an optional embodiment of the present application, the time parameter corresponding to the to-be-measured time comprises the to-be-measured time and N+1 period times closest to the to-be-measured time (excluding the to-be-measured time). It can be understood that the time length of N continuous heart cycles closest to the to-be-measured time can be determined through N+1 period times, N can be preset according to actual needs, N is a natural number greater than or equal to 0, for example, N can be 1, 2, 3, 4, etc., and N is used to represent the number of continuous heart cycles for averaging arterial pressure, and in this embodiment, N is 3.

[0123] In other embodiments, the time parameter corresponding to the to-be-measured time can also only comprise the to-be-measured time, the period time closest to the to-be-measured time, the period time closest to the to-be-measured time, the period time closest to the to-be-measured time, and the period time closest to the to-be-measured time. It can be understood that the time length of the Nth heart cycle closest to the to-be-measured time can be determined through the period time closest to the to-be-measured time and the period time closest to the to-be-measured time, and the time length of the nearest heart cycle to the to-be-measured time can be determined according to the period time closest to the to-be-measured time and the period time closest to the to-be-measured time.

[0124] S1032, determining a target time period corresponding to the to-be-measured time according to the time parameter.

[0125] In an optional embodiment of the present application, step S1032 of determining a target time period corresponding to the to-be-measured time according to the time parameter specifically comprises the following steps:

[0126] A1, determining whether the to-be-measured time is a period time, if the to-be-measured time is a period time, executing step A2; if the to-be-measured time is not a period time, executing steps A3 and A4;

[0127] A2, determining the time period between the Nth period time in the time parameter and the to-be-measured time as the target time period corresponding to the to-be-measured time;

[0128] A3, calculating a first time difference between the to-be-measured time and the first period time in the time parameter, and a second time difference between the first period time in the time parameter and the second period time in the time parameter;

[0129] A4, judging whether the first time difference is less than the second time difference; if the first time difference is greater than or equal to the second time difference, step A5 is executed; if the first time difference is less than the second time difference, step A6 is executed;

[0130] A5, determining a time period between the Nth periodic time in the time parameter and the to-be-detected time as a target time period corresponding to the to-be-detected time;

[0131] A6, delaying the N+1th periodic time in the time parameter by a patching time length to obtain a first time, and determining a time period between the first time and the to-be-detected time as a target time period corresponding to the to-be-detected time; wherein the patching time length calculation formula is: Wherein, Δt is the patching time length, t1 is the first periodic time in the time parameter (that is, the periodic time closest to the to-be-detected time), t2 is the second periodic time in the time parameter (that is, the second closest periodic time to the to-be-detected time), t n+1 is the N+1th periodic time in the time parameter (that is, the N+1th closest periodic time to the to-be-detected time), t n is the Nth periodic time in the time parameter (that is, the Nth closest periodic time to the to-be-detected time), and t i is the to-be-detected time.

[0132] In an optional embodiment of the application, the target time period corresponding to the to-be-detected time is calculated according to the time parameter, which can have at least the following three cases (assuming that the to-be-detected time is the current time, and the periodic number N is 3):

[0133] Case one: please refer to Figure 3a , Figure 3a is a schematic diagram of determining a target time period disclosed by an embodiment of the application. As shown in FIG. 3, if the blood pressure measurement value received at the current time has periodic characteristics (that is, the current time is a periodic time), in this case, the starting time of the target time period is the Nth closest periodic time t n to the current time (excluding the current time), the ending time of the target time period is the current time t i , the time length t sum of the target time period is t i -t n , t sum represents the time length of the target time period, t i represents the current time, and t n is the Nth periodic time in the time parameter.

[0134] It can be understood that in a typical case, the blood pressure measurement value sampled at the current time is identified as having a periodic characteristic, at this time, the starting time of the target time period is directly calculated from the current time to the time point of N periods, so as to realize that one or more complete cardiac cycles are taken as the target time period for calculating mean arterial pressure, and the accuracy and rationality of mean arterial pressure measurement are realized.

[0135] Figure 3a A schematic diagram for determining the target time period based on case one is shown as Figure 3a shown, when N=3 and the periodic characteristic is DAP, the starting time of the target time period is the third closest period time point from the current time, and the ending time of the target time period is the current time.

[0136] Case two: please refer to Figure 3b , Figure 3b is another schematic diagram for determining the target time period disclosed by the embodiment of the present application. As shown in Figure 3b shown, if the blood pressure measurement value received at the current time does not have a periodic characteristic, and the time difference between the nearest period time point and the current time is less than the time difference between the nearest two period time points (i.e. the length of the nearest cardiac cycle), in this case, the Nth closest cardiac cycle needs to be interpolated. The starting time of the target time period=t n+1 +Δt, wherein t n+1 is the N+1th period time point in the time parameter, i.e. the N+1th closest period time point from the current time; Δt is the interpolation length, specifically, wherein t i is the current time, t1 represents the nearest period time point from the current time (i.e. the first period time point in the time parameter); T recent is the length of the nearest cardiac cycle from the current time, T recent =t1-t2, t1 is the first period time point in the time parameter, and t2 is the second period time point in the time parameter; S T [0] represents the length of the Nth closest cardiac cycle from the current time, S T [0]=t n -t n+1 , t n+1 is the N+1th period time point in the time parameter, and t n is the Nth period time point in the time parameter. The ending time of the ending time of the target time period is the current time t i . The length of the target time period t sum =SUM(S T )-Δt+(t i -t1), wherein t sum represents the length of the target time period, SUM(ST ) represents the total duration of the N consecutive cardiac cycles closest to the current moment, and Δt represents the cut-and-paste duration, t i Indicates the current moment.

[0137] It is understandable that if the current moment is within a complete cardiac cycle but the entire cardiac cycle has not yet been completed, the relative position of the current moment within the current cardiac cycle can be calculated. Then, the cardiac cycle closest to the current time is segmented and padded to obtain an averaging range of one or more cardiac cycles that are close to a complete cardiac cycle when the complete cardiac cycle is not completed. This results in a more accurate time range for calculating mean arterial pressure, further increasing the accuracy and rationality of mean arterial pressure measurement.

[0138] Figure 3b This is a diagram illustrating the determination of the target time period based on scenario two, as shown below. Figure 3b As shown, when N=3 and the periodic characteristic is DAP, the start time of the target time period = the fourth nearest period time to the current time + Δt, and the end time of the target time period is the current time. To obtain the target time period of three consecutive cardiac cycles from the current time in this scenario, the portion corresponding to the cardiac cycle process experienced at the current time is cut off from the third nearest cardiac cycle. Thus, the time period from the cut-off point to the current time can be considered as three cardiac cycles. Therefore, this method obtains three complete cardiac cycles as the time range for calculating mean arterial pressure, further increasing the accuracy and rationality of mean arterial pressure measurement.

[0139] Scenario 3: Please refer to Figure 3c , Figure 3c This is a schematic diagram illustrating another method for determining a target time period as disclosed in an embodiment of the present invention. For example... Figure 3c As shown, if the blood pressure measurement received at the current moment does not have a periodic characteristic, and the time difference between the most recent cycle moment and the current moment is greater than or equal to the time difference between the two most recent cycle moments (i.e., the duration of the most recent cardiac cycle), then in this case, the start time of the target time period is the Nth cycle moment t closest to the current moment. n The end time of the target time period is the current time t. i The duration t of the target time period sum =SUM(S T )-S T [0]+(t i -t1), where t sum SUM(S) represents the duration of the target time period. T t represents the total duration of the N consecutive cardiac cycles closest to the current moment. i Indicates the current time, t jS represents the periodic time closest to the current time. T [0] represents the time difference between the (N+1)th nearest period and the Nth nearest period (i.e. the duration of the Nth nearest cardiac cycle).

[0140] Understandably, in this situation, the duration of the current cardiac cycle is greater than the most recent cardiac cycle, making the time interval from the most recent cycle moment to the current moment greater than the time difference between the two most recent cycle moments. If the value is greater than 1, cutting and patching according to this ratio will lead to erroneous cutting, thus increasing the calculation error. To prevent this drawback, the start time of the target time period is set to the Nth periodic time closest to the current time, until the next periodic feature appears.

[0141] Figure 3c This is a diagram illustrating the determination of the target time period based on scenario three, as shown below. Figure 3c As shown, when N=3 and the periodicity is DAP, the start time of the target time period is the Nth closest periodic time to the current time, and the end time of the target time period is the current time. The duration t of the target time period... sum Alternatively, it can be determined directly by subtracting the Nth period closest to the current time from the current time.

[0142] S104. Filter blood pressure measurements within the target time period from the pressure measurement data.

[0143] In this embodiment of the invention, the pressure measurement data includes multiple consecutive blood pressure measurements from the same measurement location. After determining the target time period, multiple blood pressure measurements within the target time period are selected from the pressure measurement data. Specifically, in this embodiment, the nearest (t) value can be taken. sum / T sp (Integer number of blood pressure measurements, where T) sp This indicates the sampling interval for blood pressure measurements, i.e., every T... sp A blood pressure measurement is collected. In other embodiments, a blood pressure measurement received within a target time period can be selected based on a pre-established correspondence between various blood pressure measurements and time. This invention does not specifically limit this method.

[0144] S105. Determine the mean arterial pressure corresponding to the time of measurement based on the blood pressure measurement values ​​within the target time period.

[0145] Specifically, after the plurality of blood pressure measurement values in the target time period are determined, the mean value of the plurality of blood pressure measurement values in the target time period is calculated, and the mean value of the plurality of blood pressure measurement values in the target time period is determined as the mean arterial pressure, and then the mean arterial pressure value at the to-be-measured moment is obtained and output through the display unit.

[0146] It can be seen that the method for determining mean arterial pressure as shown in Figure 1 the method for determining mean arterial pressure can obtain instantaneous blood pressure measurement values in real time, detect the periodic characteristics based on the plurality of blood pressure measurement values obtained continuously, determine the time range of the mean arterial pressure at the current moment according to the detection result of the periodic characteristics, and obtain the value of the MAP in a strict sense rather than an approximate value. The mean arterial pressure is calculated considering the instantaneous values of blood pressure other than diastolic pressure and systolic pressure in the cardiac cycle. Meanwhile, the target time period is determined according to the change of the cardiac cycle, the influence of the cardiac cycle is considered in determining the time range of the mean arterial pressure at the current moment, the accuracy and rationality of the mean arterial pressure measurement are increased, and the mean arterial pressure can be detected without waiting for a complete cardiac cycle to be identified. The calculation of the mean arterial pressure can be real-time and continuous, and the efficiency of detecting the mean arterial pressure is improved.

[0147] Embodiment Two

[0148] Please refer to Figure 4 , Figure 4 is a flowchart of a method for determining mean arterial pressure according to an embodiment of the present application. In the method for determining mean arterial pressure as described above, Figure 4 the method for determining mean arterial pressure can be applied to an electronic device, such as a controller, a processor, etc. connected with a medical instrument, of course, the electronic device can also be a terminal device or a server. As shown in Figure 4 the method for determining mean arterial pressure can include the following operations:

[0149] S201, obtaining pressure measurement data, the pressure measurement data including a plurality of continuous blood pressure measurement values.

[0150] In the embodiment of the present application, the target object enters the target measurement position in the patient's body to obtain the above-mentioned pressure measurement data, and the pressure measurement data includes a plurality of continuous first blood pressure measurement values positioned on the distal side of the target object and a plurality of continuous second blood pressure measurement values positioned on the proximal side of the target object. The target object can be one of a blood pressure measurement member (such as a catheter with pressure measurement function, a guide wire with pressure measurement function, etc.), a blood pump / blood pump component (such as a pump shell), an ablation needle, a guide sheath for carrying an ablation needle, etc. The proximal side of the target object is closer to the proximal end of the target object than the distal side of the target object.

[0151] S202, periodic feature detection is performed on the pressure measurement data to obtain a periodic feature detection result, wherein the periodic feature detection result comprises a periodic feature and a periodic time point, the periodic time point is a time point at which the periodic feature appears, a time difference between two adjacent periodic time points corresponds to a length of a cardiac cycle, and the periodic feature is a feature value that appears only once in a cardiac cycle.

[0152] In the embodiment of the present application, periodic feature detection is performed on the received first blood pressure measurement value and / or second blood pressure measurement value to obtain a periodic feature detection result of the first blood pressure measurement value and / or a periodic feature detection result of the second blood pressure measurement value.

[0153] S203, determining a target time period corresponding to the to-be-measured time point according to the periodic feature detection result.

[0154] It should be noted that, since the first blood pressure measurement value and the second blood pressure measurement value are blood pressure measurement data of the same patient at different positions in the blood vessel, the plurality of first blood pressure measurement values and the plurality of second blood pressure measurement values have the same periodic change following the cardiac cycle of the patient, and the target time period corresponding to the to-be-measured time point is also the same.

[0155] In the embodiment of the present application, for other detailed descriptions of steps S201 to S203, please refer to the detailed description of steps S101 to S103 in Embodiment 1, which will not be repeated here.

[0156] S204, filtering blood pressure measurement values in the target time period from the pressure measurement data.

[0157] In the embodiment of the present application, a plurality of first blood pressure measurement values in the target time period and a plurality of second blood pressure measurement values in the target time period are filtered from the pressure measurement data.

[0158] S205, determining a first mean arterial pressure and a second mean arterial pressure corresponding to the to-be-measured time point according to the blood pressure measurement values in the target time period.

[0159] In the embodiment of the present application, the first mean arterial pressure of the to-be-measured time point is calculated according to the received first blood pressure measurement value in the target time period, and the second mean arterial pressure of the to-be-measured time point is calculated according to the received second blood pressure measurement value in the target time period.

[0160] In the embodiment of the present application, optionally, the mean arterial pressure corresponding to the to-be-measured time point is determined according to the blood pressure measurement values in the target time period, specifically comprising:

[0161] calculating a mean value of the plurality of first blood pressure measurement values in the target time period to obtain the first mean arterial pressure corresponding to the to-be-measured time point;

[0162] Calculate the mean value of the plurality of second blood pressure measurement values in the target time period, to obtain a second mean arterial pressure corresponding to the to-be-measured moment.

[0163] S206, determine target information according to the first mean arterial pressure and the second mean arterial pressure.

[0164] In the embodiment of the application, according to the first mean arterial pressure and the second mean arterial pressure of the to-be-measured moment, the target information matched with the target object can be determined.

[0165] Optionally, the target information is a blood flow reserve fraction, and the target object is a blood pressure measurement component (such as a catheter provided with a pressure measurement unit, a guide wire provided with a pressure measurement unit, etc.). The step S206 of determining the target information according to the first mean arterial pressure and the second mean arterial pressure can include:

[0166] Calculate the ratio of the first mean arterial pressure to the second mean arterial pressure, and determine the ratio of the first mean arterial pressure to the second mean arterial pressure as the blood flow reserve fraction.

[0167] In an optional embodiment of the application, the blood flow reserve fraction FFR (Fractional Flow Reserve) of the coronary artery is a technical index for evaluating the severity of vascular stenosis (including ischemia-induced lesions). The calculation method of FFR is the ratio of the distal pressure measurement value (obtained on the distal side of the blood vessel) to the proximal pressure measurement value (obtained on the proximal side of the blood vessel). That is, the blood flow reserve fraction of the to-be-measured moment = first mean arterial pressure / second mean arterial pressure.

[0168] It should be noted that, since the first blood pressure measurement value and the second blood pressure measurement value are blood pressure measurement data of the same patient at different positions in the blood vessel, the plurality of first blood pressure measurement values and the plurality of second blood pressure measurement values follow the same periodic change of the patient's cardiac cycle, and the target time period corresponding to the to-be-measured moment is also the same.

[0169] It can be understood that, in the embodiment, the continuous plurality of first blood pressure measurement values and the plurality of second blood pressure measurement values are obtained in real time, and the periodic characteristics are detected based on the continuously obtained plurality of blood pressure measurement values. According to the detection result of the periodic characteristics, the time range of the current moment first mean arterial pressure and the second mean arterial pressure is determined. The first mean arterial pressure and the second mean arterial pressure are calculated considering the blood pressure instantaneous value in the diastolic pressure and the systolic pressure in the cardiac cycle. At the same time, the target time period is determined according to the change of the cardiac cycle. The influence of the cardiac cycle is considered in determining the time range of the current moment first mean arterial pressure and the second mean arterial pressure, so that the blood flow reserve fraction calculated according to the first mean arterial pressure and the second mean arterial pressure is more accurate, and real-time and continuity can be realized.

[0170] Optionally, the target information is a position condition of the blood pump, and the target object is a pump shell of the blood pump. The step S206 of determining the target information according to the first mean arterial pressure and the second mean arterial pressure can include:

[0171] calculating a ratio and / or a difference between the second mean arterial pressure and the first mean arterial pressure;

[0172] determining the position condition of the blood pump according to the ratio and / or the difference between the second mean arterial pressure and the first mean arterial pressure.

[0173] It should be understood that the blood pump in the blood pump system receives blood from the blood vessel system of the patient and pushes the blood back to the blood vessel system of the patient to assist blood circulation. By increasing the momentum and pressure of the blood flowing through the blood pump, the blood pump can enhance or replace the pumping action of the heart. In some cases, the blood pump needs to be placed in the left ventricle to help increase the pumping of the heart. The blood pump is sent from the aorta, and the first pressure sensor positioned at the distal side of the pump shell and the second pressure sensor positioned at the proximal side of the pump shell respectively measure the mean arterial pressure at the positions. If the ratio or the difference between the second mean arterial pressure measured by the second pressure sensor at the current time and the first mean arterial pressure measured by the first pressure sensor is less than a corresponding preset value, it indicates that the blood pump has not yet entered the heart chamber. At this time, continue to advance the blood pump. If the ratio or the difference between the second mean arterial pressure measured by the second pressure sensor at the current time and the first mean arterial pressure measured by the first pressure sensor is greater than or equal to the corresponding preset value, it indicates that the distal side of the blood pump has entered the left ventricle, and the proximal side of the blood pump has not yet entered the left ventricle. The value of the preset value is associated with the pressure difference or ratio between the pressure in the left ventricle and the aorta, and can be determined according to the actual application needs. Generally speaking, taking the ratio as an example, the preset value is greater than 1, for example, the preset value is 2, of course, the preset value can also be other values. If the ratio of the second mean arterial pressure at the current time and the first mean arterial pressure is greater than or equal to 2, it indicates that the blood pump has entered the left ventricle at this time. The preset value can be set according to actual needs.

[0174] It can be understood that by determining the position condition of the blood pump based on the first mean arterial pressure and the second mean arterial pressure, the intraoperative operation is guided, and the safety and reliability of the blood pump system can be improved.

[0175] Optionally, the target information is a radiofrequency ablation degree, and the target object is an ablation needle or a guide sheath for carrying the ablation needle. The target information is a radiofrequency ablation degree. The step S206 of determining the target information according to the first mean arterial pressure and the second mean arterial pressure can include:

[0176] calculating a ratio and / or a difference between the first mean arterial pressure and the second mean arterial pressure, and determining the radiofrequency ablation degree according to the ratio and / or the difference between the first mean arterial pressure and the second mean arterial pressure.

[0177] In an optional embodiment of the present application, for a patient with hypertrophic cardiomyopathy, the typical feature of hypertrophic cardiomyopathy is that the muscle tissue of the interventricular septum is hypertrophic, thereby causing the left ventricular cavity volume to decrease. The radiofrequency ablation system ablates the hypertrophic myocardial tissue of the interventricular septum by means of radiofrequency ablation through a guide sheath. The blood pressure difference of the left ventricular outflow tract (LVOT) is positively correlated with the degree of interventricular septal obstruction, and directly reflects the blood flow condition of the left ventricular outflow tract. According to the first mean arterial pressure and the second mean arterial pressure at the current time, the difference and / or the ratio of the first mean arterial pressure and the second mean arterial pressure are calculated. Generally, the smaller the difference between the first mean arterial pressure and the second mean arterial pressure, the better the ablation effect, and the closer the ratio of the second mean arterial pressure to the first mean arterial pressure to 1, the better the ablation effect.

[0178] It can be understood that, in the process of cardiac radiofrequency ablation, the first pressure sensor is positioned in the left ventricle, and the second pressure sensor is positioned in the aorta. According to the mean arterial pressures measured by the first pressure sensor and the second pressure sensor, the pressure difference or the pressure ratio between the left ventricle and the aorta can be calculated for the clinician to interpret, so as to be able to evaluate the ablation effect in real time.

[0179] Embodiment three

[0180] Please refer to Figure 5 , Figure 5 is a structural schematic diagram of a mean arterial pressure determination device disclosed by an embodiment of the present application. As shown in Figure 5 , the mean arterial pressure determination device comprises an acquisition module 501, a detection module 502, a first determination module 503, a screening module 504, and a second determination module 505.

[0181] The acquisition module 501 is configured to acquire pressure measurement data, wherein the pressure measurement data comprises a plurality of continuous blood pressure measurement values.

[0182] The detection module 502 is configured to perform periodic feature detection on the pressure measurement data to obtain a periodic feature detection result, wherein the periodic feature detection result comprises a periodic feature and a periodic time point. The periodic time point is a time point at which the periodic feature appears. The time difference between adjacent two periodic time points corresponds to the time length of one cardiac cycle. The periodic feature is a characteristic value that appears only once in one cardiac cycle.

[0183] The first determination module 503 is configured to determine a target time period corresponding to a to-be-measured time point according to the periodic feature detection result.

[0184] The screening module 504 is configured to screen blood pressure measurement values in the target time period from the pressure measurement data.

[0185] The second determining module 505 is configured to determine the mean arterial pressure corresponding to the to-be-measured time according to the blood pressure measurement value in the target time period.

[0186] Optionally, referring to Figure 6 , Figure 6 is a structural schematic diagram of another mean arterial pressure determining device disclosed by the embodiment of the present application. As shown in Figure 6 , the first determining module 503 includes a time parameter sub-module 5031 and a target time period sub-module 5032.

[0187] The time parameter sub-module 5031 is configured to determine the time parameter corresponding to the to-be-measured time according to the period feature detection result and the preset period number N, wherein the time parameter includes N+1 period times earlier than the to-be-measured time and closest to the to-be-measured time, and N is a natural number greater than or equal to 0. The greater N is, the farther the period time corresponding to N is from the to-be-measured time.

[0188] The target time period sub-module 5032 is configured to determine the target time period corresponding to the to-be-measured time according to the time parameter.

[0189] Optionally, the specific manner in which the target time period sub-module 5032 determines the target time period corresponding to the to-be-measured time according to the time parameter includes:

[0190] determining whether the to-be-measured time is a period time, if the to-be-measured time is a period time, determining the time period between the Nth period time in the time parameter and the to-be-measured time as the target time period corresponding to the to-be-measured time;

[0191] if the to-be-measured time is not a period time, determining the time period between the Nth period time in the time parameter and the to-be-measured time as the target time period corresponding to the to-be-measured time;

[0192] calculating a first time difference between the to-be-measured time and the first period time in the time parameter, and a second time difference between the first period time in the time parameter and the second period time in the time parameter;

[0193] determining whether the first time difference is less than the second time difference;

[0194] if the first time difference is greater than or equal to the second time difference, determining the time period between the Nth period time in the time parameter and the to-be-measured time as the target time period corresponding to the to-be-measured time;

[0195] if the first time difference is less than the second time difference, delaying the N+1th period time in the time parameter by a fill-in time length to obtain a first time, and determining the time period between the first time and the to-be-measured time as the target time period corresponding to the to-be-measured time; wherein the fill-in time length calculation formula is: Wherein, Δt is the time length of the interpolation, t1 is the first period in the time parameter, t2 is the second period in the time parameter, t n+1 is the N+1 period in the time parameter, t n is the N period in the time parameter, t i is the time to be measured.

[0196] Optionally, the periodic feature is diastolic pressure, systolic pressure or dicrotic notch.

[0197] Optionally, the pressure measurement data comprises a plurality of continuous blood pressure measurement values from the same measurement position; the blood pressure measurement value in the target time period is the plurality of blood pressure measurement values in the target time period, and the second determination module 505 comprises:

[0198] A first calculation submodule for calculating the mean of the plurality of blood pressure measurement values in the target time period, and determining the mean of the plurality of blood pressure measurement values in the target time period as the mean arterial pressure.

[0199] Optionally, the pressure measurement data comprises a plurality of continuous first blood pressure measurement values positioned on the distal side of the target object and a plurality of continuous second blood pressure measurement values positioned on the proximal side of the target object; the blood pressure measurement value in the target time period comprises the plurality of first blood pressure measurement values in the target time period and the plurality of second blood pressure measurement values in the target time period;

[0200] The second determination module 505 comprises:

[0201] A second calculation submodule for calculating the mean of the plurality of first blood pressure measurement values in the target time period to obtain the first mean arterial pressure corresponding to the time to be measured, and for calculating the mean of the plurality of second blood pressure measurement values in the target time period to obtain the second mean arterial pressure corresponding to the time to be measured.

[0202] Optionally, referring to Figure 7 , Figure 7 is another structure diagram of the mean arterial pressure determination device disclosed by the embodiment of the present application. As shown in Figure 7 , the mean arterial pressure determination device further comprises a third determination module 506.

[0203] The third determination module 506 is configured to determine the target information according to the first mean arterial pressure and the second mean arterial pressure.

[0204] In the optional embodiment of the present application, according to the first mean arterial pressure and the second mean arterial pressure of the time to be measured, the target information matched with the target object can be determined.

[0205] Optionally, when the target object is a blood pressure measurement component, the target information is a blood flow reserve fraction. The third determining module 506 determines the target information according to the first mean arterial pressure and the second mean arterial pressure in the following manner:

[0206] calculating a ratio of the first mean arterial pressure to the second mean arterial pressure, and determining the ratio of the first mean arterial pressure to the second mean arterial pressure as the blood flow reserve fraction.

[0207] Optionally, when the target object is a pump shell of a blood pump, the target information is a position condition of the blood pump. The third determining module 506 determines the target information according to the first mean arterial pressure and the second mean arterial pressure in the following manner:

[0208] calculating a ratio and / or a difference of the second mean arterial pressure to the first mean arterial pressure;

[0209] determining the position condition of the blood pump according to the ratio and / or the difference of the second mean arterial pressure to the first mean arterial pressure.

[0210] Optionally, when the target object is an ablation needle or a guide sheath for carrying the ablation needle, the target information is a radiofrequency ablation degree.

[0211] The third determining module 506 determines the target information according to the first mean arterial pressure and the second mean arterial pressure in the following manner:

[0212] calculating a ratio and / or a difference of the first mean arterial pressure to the second mean arterial pressure, and determining the radiofrequency ablation degree according to the ratio and / or the difference of the first mean arterial pressure to the second mean arterial pressure.

[0213] It should be understood that, for other detailed descriptions of the above-mentioned various modules / units, please refer to the corresponding descriptions in Embodiment One or Embodiment Two, which will not be repeated herein.

[0214] Embodiment Four

[0215] Please refer to Figure 8 , Figure 8 is a structural schematic diagram of an electronic device disclosed in an embodiment of the present application. As shown in Figure 8 , the electronic device can include:

[0216] a memory 801 storing executable program codes;

[0217] a processor 802 coupled with the memory;

[0218] The processor 802 invokes the executable program codes stored in the memory 801 to execute the steps in the mean arterial pressure determination method described in Embodiment One or Embodiment Two of the present application.

[0219] Embodiment Five

[0220] The embodiment of the present application discloses a computer readable storage medium, the computer storage medium stores executable program code, when the executable program code is called, the steps in the determination method of mean arterial pressure described in the embodiment one or the embodiment two of the present application are executed.

[0221] Embodiment six

[0222] As Figure 9 shown, the embodiment of the present application discloses a pressure measurement system, examples of the pressure measurement system can be a blood pump system, an ablation system, a pressure gradient sensing system, etc. The pressure measurement system comprises a pressure measurement device 1a and a processing device 2a, wherein,

[0223] The pressure measurement device 1a comprises:

[0224] An elongated body 11a extending axially between a proximal end and a distal end, examples of the elongated body 11a can be a catheter, a guide wire, a blood pump housing, an ablation needle, a guide sheath carrying an ablation needle, etc.

[0225] A base 12a connected to the proximal end of the elongated body 11a, which is usually a handheld part of the elongated body 11a manipulated and operated by a clinician during a surgical procedure, so the base 12a can also be called a handle, which is used to be manipulated and operated by a clinician during a surgical procedure to control the elongated body 11a to advance or retreat in a blood vessel.

[0226] A pressure sensing unit 13a arranged on the elongated body 11a for sensing blood pressure to obtain pressure measurement data. The pressure sensing unit 13a comprises at least one pressure sensor 13a'. The pressure sensor 13a' is electrically connected to the processing device 2a through a wire for sending the measured pressure measurement data to the processing device 2a. In other embodiments, the wire can not be necessary, and the measured pressure measurement data can be sent to the processing device 2a through at least one of wireless communication modes such as GPRS communication, 2.4G communication, WiFi communication, ZigBee communication, Bluetooth communication, etc.

[0227] The pressure sensor 13a' can be any of various types of pressure sensors incorporated into the elongated body 11a for vascular pressure measurement applications. For example, the pressure sensor 13a' can be a piezoresistive pressure sensor, a piezoelectric pressure sensor, a capacitive pressure sensor, an electromagnetic pressure sensor, an optical pressure sensor, a fluid column pressure sensor, and / or combinations thereof.

[0228] The processing device 2a comprises a communication interface 21a, a memory 22a and a processor 23a, wherein the communication interface 21a is configured to receive and transmit information between the processing device 2a and the pressure measurement device 1a, for example, the communication interface 21a can be configured to receive pressure measurement data from the pressure sensor 13a'. In various system configurations, the pressure measurement data can be received at the communication interface 21a in analog or digital form. In certain embodiments, signal processing hardware and digitization can be housed in the base 12a to filter, amplify and / or digitize the pressure measurement data. In other embodiments, the pressure measurement data can be received and digitized at the communication interface 21a of the processing device 2a.

[0229] The memory 22a is used to store executable program code for determining mean arterial pressure and other required data and information, the executable program code comprises instructions which, when executed by the processor 23a, cause the processing device 2a to implement the steps in the method of determining mean arterial pressure described in embodiment one of the present application. The method of determining mean arterial pressure can refer to the above-mentioned embodiment one, and will not be described here again. Naturally, since the pressure measurement system of the present embodiment adopts the technical solutions of the above-mentioned embodiment one, the pressure measurement system has all the beneficial effects of the above-mentioned embodiment one.

[0230] Embodiment seven

[0231] Please refer to Figure 10 , Figure 10 is a structural schematic diagram of a pressure gradient sensing system disclosed by an embodiment of the present application. As shown in Figure 10 , the present embodiment provides a pressure gradient sensing system for quickly and accurately judging the fractional flow reserve FFR of a coronary artery vessel before, during and / or after a percutaneous coronary intervention surgery. The FFR is a technical index for evaluating the severity of a vessel stenosis (including an ischemia-induced lesion), and the FFR is calculated as the ratio of a distal pressure measurement value (obtained at the distal side of the vessel) to a proximal pressure measurement value (obtained at the proximal side of the vessel). As a technical index of the degree of vessel lesion, a doctor can evaluate whether treatment is needed and the corresponding treatment method according to the FFR. The normal value of the FFR in a healthy blood vessel is 1.00, and an FFR value less than a threshold value is generally considered to be significant and requires treatment. At present, 0.80 is the recommended reference standard for FFR evaluation of myocardial ischemia, and lesions with FFR < 0.75 are suitable for revascularization, and lesions with FFR > 0.80 are an indication for drug treatment. The FFR between 0.75 and 0.80 is in the "gray zone", and the operator can determine whether to perform revascularization in combination with the clinical condition of the patient and the importance of blood supply of the vessel. Based on the above, the threshold value can be selected between 0.75 and 0.80.

[0232] In particular, FFR is calculated using the following formula: FFR = Pd / Pa, where Pd is the pressure distal to the vessel and Pa is the pressure proximal to the vessel. Thus, an FFR of 1.0 means that the pressure distal to the vessel is the same as the pressure proximal to the vessel, i.e. the vessel is normal and not impeding blood flow.

[0233] The pressure gradient sensing system comprises a pressure sensing device 1b and a processing device 2b, the pressure sensing device 1b comprises:

[0234] An elongated body 11b extending between a proximal end and a distal end in an axial direction, examples of the elongated body 11b can be a guidewire or a guide sheath, etc.

[0235] A base 12b connected to the proximal end of the elongated body 11b, which is a hand-held part of the elongated body 11b usually manipulated and operated by a clinician during a procedure, thus the base 12b can also be referred to as a handle, for being manipulated and operated by the clinician during the procedure to control the elongated body 11b to be advanced or withdrawn within a blood vessel.

[0236] A pressure measuring unit 13b provided on the elongated body 11b for sensing blood pressure to obtain pressure measurement data. In the present embodiment, the pressure measuring unit 13b comprises a first pressure sensor 13b’ and a second pressure sensor 13b”, the first pressure sensor 13b’ and the second pressure sensor 13b” are provided on an outer peripheral wall of the elongated body 11b and arranged spaced apart along an axial direction of the elongated body 11b, the first pressure sensor 13b’ is located on a distal side of the second pressure sensor 13b”, that is, the first pressure sensor 13b’ is closer to the distal end of the elongated body 11b relative to the second pressure sensor 13b”. The first pressure sensor 13b’ and the second pressure sensor 13b” are respectively electrically connected to the processing device 2b through wires for respectively sending the measured pressure measurement data to the processing device 2b. In other embodiments, the wires can be unnecessary, and the measured pressure measurement data can be sent to the processing device 2b through at least one of wireless communication modes such as GPRS communication, 2.4G communication, WiFi communication, ZigBee communication, Bluetooth communication, etc.

[0237] The first pressure sensor 13b’ and the second pressure sensor 13b” can be any of various types of pressure sensors incorporated into the elongated body 11b for blood vessel pressure measurement applications. For example, the first pressure sensor 13b’, the second pressure sensor 13b” can be a piezoresistive pressure sensor, a piezoelectric pressure sensor, a capacitive pressure sensor, an electromagnetic pressure sensor, an optical pressure sensor, a fluid column pressure sensor, and / or combinations thereof.

[0238] It will be appreciated that the first pressure sensor 13b' is configured to measure the distal vessel pressure Pd and the second pressure sensor 13b" is configured to measure the proximal vessel pressure Pa, and the processing device 2b receives the distal vessel pressure Pa measured by the first pressure sensor 13b' and the proximal vessel pressure Pd measured by the second pressure sensor 13b", and determines at least one fractional flow reserve FFR based on the distal vessel pressure Pa measured by the first pressure sensor 13b' and the proximal vessel pressure Pd measured by the second pressure sensor 13b".

[0239] The processing device 2b comprises a communication interface 21b, a memory 22b and a processor 23b. The communication interface 21b is configured to receive and transmit information between the processing device 2b and the pressure sensing device 1b, for example, the communication interface 21b can be configured to receive pressure measurement data from the first pressure sensor 13b' and the second pressure sensor 13b". In various system configurations, the pressure measurement data can be received at the communication interface 21b in analog or digital form. In certain embodiments, signal processing hardware and digitization can be housed in the base 12b to filter, amplify, and / or digitize the pressure measurement data. In other embodiments, raw analog pressure measurement information can be received at the communication interface of the processing device 2b and digitized.

[0240] The memory 22b is configured to store executable program code for calculating FFR and other required data and information, the executable program code comprising instructions that, when executed by the processor 23b, cause the processing device 2b to implement the method of determining the target information, i.e. at least one fractional flow reserve FFR based on the pressure measurement data measured by the first pressure sensor 13b' and the second pressure sensor 13b", when the target information is fractional flow reserve as in the second embodiment of the present application. It will be appreciated that since the pressure gradient sensing system of the present embodiment employs the technical solution of the second embodiment described above, the pressure gradient sensing system has all the beneficial effects of the second embodiment described above.

[0241] It is important to note that the FFR value is not calculated based on a comparison of a single pressure value, as such a calculation would be overly influenced by noise or transients of the measurement. Therefore, the FFR value is typically calculated based on an average arterial pressure over a period of time, such as an average arterial pressure over a single heartbeat or a set number of heartbeats (where a heartbeat corresponds to a cardiac cycle). By utilizing pressure measurement data over a period of time, the influence of noise and other artifacts is minimized. Likewise, by utilizing data from multiple heartbeats, variations between heartbeats can also be minimized. For example, the FFR value over one or more cardiac cycles can be calculated based on a running average of the ratio over a certain number of heartbeats. That is, the FFR value over a period of time is equal to the ratio of the average arterial pressure of the distal vessel over the period of time to the average arterial pressure of the vessel proximally over the period of time.

[0242] Embodiment Eight

[0243] Referring to Figure 11 , Figure 11 is a structural schematic diagram of a blood pump system according to an embodiment of the present application. As shown in Figure 11 , the blood pump system is provided for assisting blood circulation for a patient with heart disease. The blood pump in the blood pump system receives blood from the patient's blood vessel system and pushes the blood back to the patient's blood vessel system to assist blood circulation. By increasing the momentum and pressure of the blood flowing through the blood pump, the blood pump can enhance or replace the pumping action of the heart. For example, the blood pump can be configured as a ventricular assist device (VAD). When the VAD is used to assist the pumping action of the left ventricle, blood is drawn from the left ventricle of the heart and discharged into the aorta. For a patient whose blood vessel system is assisted by the VAD, it is necessary to regularly or continuously monitor the mean arterial pressure of the patient to obtain the blood pressure parameter of the patient, so as to facilitate the clinician to judge the physical condition of the patient. Specifically, the mean arterial pressure can reflect the perfusion pressure of the organs and is an important basis for evaluating the blood flow volume and flow rate change of the heart and peripheral blood vessels. In addition, the difference in mean arterial pressure measured by the pressure sensors arranged at different positions in the patient's body can also be used to judge the relative position of the blood pump in the patient's body, which has an important guiding role for intraoperative operation. Therefore, it is necessary to regularly or even continuously monitor the mean arterial pressure of the patient based on the blood pressure information collected from the blood pump controlled thereby.

[0244] The blood pump system comprises a blood pump assembly 1c and a processing device 2c.

[0245] The blood pump assembly 1c comprises:

[0246] a pump housing 11c having an axis;

[0247] a rotor (not shown) disposed in the pump housing 11c and rotatable about the axis;

[0248] and a pressure sensing unit 13c disposed on the pump housing for sensing blood pressure to obtain pressure measurement data. In the present embodiment, preferably, in order to more accurately detect the position condition of the blood pump, the pressure sensing unit 13c includes a first pressure sensor 13c' and a second pressure sensor 13c" which are spaced apart in the axial direction of the pump housing 11c, specifically, the first pressure sensor 13c' is located at the distal end side of the pump housing 11c, and the second pressure sensor 13c" is located at the proximal end side of the pump housing 11c, that is, the first pressure sensor 13c' is closer to the distal end of the pump housing 11c than the second pressure sensor 13c". The first pressure sensor 13c' and the second pressure sensor 13c" are respectively electrically connected to the processing device 2c through wires for respectively sending the measured pressure measurement data to the processing device 2c. In other embodiments, the wires can not be necessary, and the measured pressure measurement data can be sent to the processing device 2c through at least one of wireless communication modes such as GPRS communication, 2.4G communication, WiFi communication, ZigBee communication, Bluetooth communication, etc.

[0249] The first pressure sensor 13c' and the second pressure sensor 13c" can be any of various types of pressure sensors incorporated into the pump housing 11c having an axis for pressure measurement applications. For example, the first pressure sensor 13b' and the second pressure sensor 13b" can be piezoresistive pressure sensors, piezoelectric pressure sensors, capacitive pressure sensors, electromagnetic pressure sensors, optical pressure sensors, fluid column pressure sensors, and / or combinations thereof.

[0250] It can be understood that the first pressure sensor 13c' is used to measure the distal end pressure Pd of the pump housing 11c, and the second pressure sensor 13b" is used to measure the proximal end pressure Pa of the pump housing 11c, the processing device 2c respectively receives the distal end blood vessel pressure Pa measured by the first pressure sensor 13c' and the proximal end blood vessel pressure Pd measured by the second pressure sensor 13c", and determines the difference of the mean arterial pressure based on the distal end blood vessel pressure Pa measured by the first pressure sensor 13b' and the proximal end blood vessel pressure Pd measured by the second pressure sensor 13b", and further judges the position condition of the blood pump in the patient's body.

[0251] The processing device 2c includes a communication interface 21c, a memory 22c, and a processor 23c, wherein the communication interface 21c is configured to receive and transmit information between the processing device 2c and the blood pump assembly 1c, for example, the communication interface 21c can be configured to receive pressure measurement data from the first pressure sensor 13c' and the second pressure sensor 13c". In various system configurations, the pressure measurement data can be received in analog or digital form at the communication interface 21c, in other embodiments, the raw analog pressure measurement information can be received and digitized at the communication interface 21c of the processing device 2c.

[0252] The memory 22c is configured to store executable program codes for determining the position condition of the blood pump and other required data and information, the executable program codes including instructions which, when executed by the processor 23c, cause the processing device 2c to implement the method for determining the target information, i.e., the position condition of the blood pump, as described in Embodiment Two of the present application, when the target information is the position condition of the blood pump, i.e., determining the target information based on the first pressure measurement data measured by the first pressure sensor 13c’ and the second pressure sensor 13c”, determining the first mean arterial pressure and the second mean arterial pressure respectively based on the first pressure measurement data and the first pressure measurement data respectively, and determining the position condition of the blood pump according to the difference or ratio between the first mean arterial pressure and the second mean arterial pressure.

[0253] It can be understood that, by monitoring the mean arterial pressure of the patient with the blood pump system, the blood pressure parameter of the patient can be obtained, thereby facilitating the clinician to judge the physical condition of the patient. Further, the processing device can also generate a control signal for controlling the rotation speed of the rotor according to the monitoring result of the blood pressure parameter. Specifically, the processing device can generate different control signals according to the monitoring result of the blood pressure parameter, thereby controlling the rotation speed of the rotor with different rotation speeds, such as high, medium and low rotation speeds. The corresponding relationship between the blood pressure parameter and the rotation speed instruction can be determined according to clinical trials and requirements, and the present application is not limited thereto.

[0254] It should be understood that the blood pump in the blood pump system receives blood from the vascular system of the patient and pushes the blood back to the vascular system of the patient to assist blood circulation. By increasing the momentum and pressure of the blood flowing through the blood pump, the blood pump can enhance or replace the pumping action of the heart. In some cases, the blood pump needs to be placed in the left ventricle to help increase the pumping of the heart. The blood pump is sent from the aorta, and the first pressure sensor positioned at the distal side of the pump housing and the second pressure sensor positioned at the proximal side of the pump housing respectively measure the mean arterial pressure at the positions. If the ratio or difference between the second mean arterial pressure measured by the second pressure sensor at the current time and the first mean arterial pressure measured by the first pressure sensor is less than the corresponding preset value, it indicates that the blood pump has not yet entered the heart chamber. At this time, the blood pump is continuously advanced. If the ratio or difference between the second mean arterial pressure measured by the second pressure sensor at the current time and the first mean arterial pressure measured by the first pressure sensor is greater than or equal to the corresponding preset value, it indicates that the distal side of the blood pump has entered the left ventricle, and the proximal side of the blood pump has not yet entered the left ventricle. The value of the preset value is associated with the pressure difference or ratio between the pressure in the left ventricle and the aorta, and can be determined according to the actual application requirements. Generally, taking the ratio as an example, the preset value is greater than 1, for example, the preset value is 2, of course, the preset value can also be other values. If the ratio of the second mean arterial pressure at the current time and the first mean arterial pressure is greater than or equal to 2, it indicates that the blood pump has entered the left ventricle at this time. The preset value can be set according to actual needs.

[0255] It should be known that the blood pump system of the embodiment adopts the technical solution of the above-mentioned embodiment two, and has all the beneficial effects of the above-mentioned embodiment two. It can be understood that the position condition of the blood pump is determined based on the first mean arterial pressure and the second mean arterial pressure, which has an important guiding effect on the intraoperative operation, and can improve the safety and reliability of the blood pump system.

[0256] Embodiment nine

[0257] Please refer to Figure 12-13 , Figure 12 is a structural schematic diagram of a radio frequency ablation system disclosed by the embodiment of the present application, Figure 13 is a structural schematic diagram of another radio frequency ablation system disclosed by the embodiment of the present application.

[0258] As shown in Figure 12 and Figure 13 , the embodiment of the present application provides a radio frequency ablation system for patients with hypertrophic cardiomyopathy. The typical feature of hypertrophic cardiomyopathy is that the muscle tissue of the left ventricular septum is hypertrophic, which leads to the decrease of the left ventricular cavity volume. The radio frequency ablation system adopts the method of radio frequency ablation through a guide sheath. Specifically, the ablation needle is carried by the conveying device, punctured into the body through the femoral artery, passes through the aortic arch and the aortic valve into the left ventricle, and then penetrates into the interventricular septum, and ablates the hypertrophic myocardial tissue of the interventricular septum.

[0259] The blood pressure difference of the left ventricular outflow tract is positively correlated with the degree of interventricular septal obstruction, and directly reflects the blood flow condition of the left ventricular outflow tract. Therefore, for patients with hypertrophic obstructive cardiomyopathy who receive interventricular septal ablation surgery, the changes of the blood pressure parameters of the left ventricular outflow tract before, during and after the surgery are important basis for evaluating the effect of the surgery. Based on the above, when performing radio frequency ablation surgery on the heart, the blood pressure parameters of the patient need to be monitored in real time and continuously for the doctor to diagnose and analyze.

[0260] Continuing as shown in Figure 12 and Figure 13 , the ablation system comprises an ablation device 1d and a processing device 2d.

[0261] The ablation device 1d comprises:

[0262] a guide sheath 11d in the form of a hollow tube;

[0263] an ablation needle 12d capable of axial movement within the guide sheath 1 Id; and a handle (not shown) for controlling the axial movement of the ablation needle. The processing device 2d is electrically connected to the ablation needle 12d via an electrical lead for transmitting radiofrequency energy to the ablation needle 12d via the electrical lead, which is released by the ablation needle 12d to the myocardial tissue for radiofrequency ablation of the myocardial tissue. In the process of radiofrequency ablation of the myocardial tissue, the distal end of the guide sheath 1 Id crosses the aortic valve into the left ventricle and is close to the interventricular septum, and the ablation needle 12d can be extended from the distal end of the guide sheath 1 Id to puncture into the myocardial tissue (for example, the interventricular septum) to release radiofrequency energy to perform radiofrequency ablation on the myocardial tissue.

[0264] The ablation device 1 d further comprises a pressure measuring unit 13d provided on the guide sheath 1 Id and / or the ablation needle 12d for sensing blood pressure to obtain pressure measurement data. In this embodiment, preferably, the pressure measuring unit 13d comprises a first pressure sensor 13d’ and a second pressure sensor 13d”. The first pressure sensor 13d’ and the second pressure sensor 13d” are respectively located at different positions on the guide sheath 1 Id in the axial direction and / or on the ablation needle 12d, so that the degree of radiofrequency ablation can be determined according to the difference between the mean arterial pressures measured by the first pressure sensor 13d’ and the second pressure sensor 13d”.

[0265] In this embodiment, the first pressure sensor 13d’ is provided on the distal side of the guide sheath 1 Id, and the second pressure sensor 13d” is provided on the proximal side of the guide sheath 1 Id, that is, the first pressure sensor 13d’ and the second pressure sensor 13d” are spaced apart in the axial direction of the guide sheath 1 Id, and the first pressure sensor 13d’ is closer to the distal end of the guide sheath 1 Id than the second pressure sensor 13d”. In other embodiments, the first pressure sensor 13d’ and the second pressure sensor 13d” can be provided on the ablation needle 12d, or one of the first pressure sensor 13d’ and the second pressure sensor 13d” is provided on the ablation needle 12d, and the other is provided on the guide sheath 1 Id, as long as the first pressure sensor 13d’ and the second pressure sensor 13d” have a spacing in the axial direction of the guide sheath 1 Id / ablation needle 12d. Preferably, the first pressure sensor 13d’ is provided on the distal end of the guide sheath 1 Id, and the spacing between the first pressure sensor 13d’ and the second pressure sensor 13d” can be set to be between 20mm and 55mm.

[0266] In some embodiments, as Figure 12As shown, during the process of cardiac radiofrequency ablation by the ablation system, the first pressure sensor 13d' is positioned in the left ventricle, and the second pressure sensor 13d" is positioned in the aorta, and the processing device 2d is configured to calculate the first mean arterial pressure and the second mean arterial pressure in real time respectively according to a plurality of continuous first blood pressure measurement values output by the first pressure sensor 13d' and a plurality of continuous second blood pressure measurement values output by the second pressure sensor 13d", and determine the degree of radiofrequency ablation of the ablation device 1d according to the difference or ratio between the first mean arterial pressure and the second mean arterial pressure, so as to provide the clinician with a judgment, thereby being able to evaluate the ablation effect in real time.

[0267] The first pressure sensor 13d' and the second pressure sensor 13d" can be piezoresistive pressure sensors, piezoelectric pressure sensors, capacitive pressure sensors, electromagnetic pressure sensors, optical pressure sensors, fluid column pressure sensors, and / or combinations thereof.

[0268] The processing device 2d includes a communication interface 21d, a memory 22d, and a processor 23d, wherein the communication interface 21d is configured to receive and transmit information between the processing device 2d and the ablation device 1d, for example, the communication interface 21d can be configured to receive pressure measurement data from the first pressure sensor 13d' and the second pressure sensor 13d". In various system configurations, the pressure measurement data can be received in analog or digital form at the communication interface 21d, and in other embodiments, raw analog pressure measurement information can be received and digitized at the communication interface 21d of the processing device 2d.

[0269] The memory 22d is used to store executable program codes for determining the degree of radiofrequency ablation and other required data and information, and the executable program codes include instructions that, when executed by the processor 23d, cause the processing device 2d to achieve the method for determining the target information as the degree of radiofrequency ablation described in Embodiment Two, that is, determining the first mean arterial pressure and the second mean arterial pressure based on the first pressure measurement data and the second pressure measurement data measured by the first pressure sensor 13d' and the second pressure sensor 13d" respectively, and then determining the degree of radiofrequency ablation according to the ratio and / or difference between the first mean arterial pressure and the second mean arterial pressure.

[0270] It should be understood that since the blood pump system of the present embodiment adopts the technical solution of Embodiment Two described above, the blood pump system has all the beneficial effects of Embodiment Two described above. It can be understood that by monitoring the mean arterial pressure of the patient receiving the interventricular septum ablation procedure, the blood pressure parameters of the patient during the cardiac radiofrequency ablation procedure can be obtained, thereby facilitating the clinician to judge the physical condition of the patient, thereby being able to evaluate the ablation effect in real time.

[0271] The apparatus embodiments described above are only illustrative, wherein the modules described as separate components can or can not be physically separated, and the components displayed as modules can or can not be physical modules, i.e., can be located in one place or distributed to multiple network modules. Part or all of the modules can be selected to achieve the purposes of the embodiments according to actual needs. Those skilled in the art can understand and implement without creative labor.

[0272] Through the specific description of the above embodiments, those skilled in the art can clearly understand that each embodiment can be realized by means of software and necessary general hardware platform, and of course can also be realized by hardware. Based on such understanding, the above technical solutions can be embodied in the form of software product, and the computer software product can be stored in a computer readable storage medium, including Read-Only Memory (ROM), Random Access Memory (RAM), Programmable Read-Only Memory (PROM), Erasable Programmable Read-Only Memory (EPROM), One-time Programmable Read-Only Memory (OTPROM), Electrically-Erasable Programmable Read-Only Memory (EEPROM), Compact Disc Read-Only Memory (CD-ROM) or other optical disk storage, magnetic disk storage, magnetic tape storage, or any other computer readable medium capable of carrying or storing data.

[0273] Finally, it should be noted that the above embodiments are only preferred embodiments of the present application, and are only used to illustrate the technical solutions of the present application, but not to limit them; although the present application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that the technical solutions recorded in the foregoing embodiments can be modified, or some technical features can be replaced by equivalents; and these modifications or replacements do not make the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present application.

Claims

1. A method of determining mean arterial pressure, characterized by, The method comprises: acquiring pressure measurement data, the pressure measurement data comprising a plurality of continuous blood pressure measurement values; performing periodic feature detection on the pressure measurement data to obtain a periodic feature detection result, wherein the periodic feature detection result comprises a periodic feature and a periodic time point, the periodic time point being a time point at which the periodic feature appears, a time difference between two adjacent periodic time points corresponding to a length of a cardiac cycle, and the periodic feature being a feature value that appears only once in a cardiac cycle; determining a time parameter corresponding to a to-be-measured time point according to the periodic feature detection result and a preset number N of cycles, and determining a target time period corresponding to the to-be-measured time point according to the time parameter, wherein the time parameter comprises N+1 periodic time points that are closest to the to-be-measured time point and earlier than the to-be-measured time point, N being a natural number greater than or equal to 0, and the greater N is, the farther the periodic time points corresponding to N are from the to-be-measured time point; screening blood pressure measurement values in the target time period from the pressure measurement data; determining mean arterial pressure corresponding to the to-be-measured time point according to the blood pressure measurement values in the target time period. The determination of the target time period corresponding to the to-be-measured time point according to the time parameter comprises: if the to-be-measured time point is not a periodic time point, calculating a first time difference between the to-be-measured time point and a first periodic time point in the time parameter, and a second time difference between the first periodic time point and a second periodic time point in the time parameter; determining whether the first time difference is less than the second time difference; If the first time difference is less than the second time difference, a first time point is obtained by delaying an N+1th period time point in the time parameters by a patching duration, a time period between the first time point and the to-be-tested time point is determined as a target time period corresponding to the to-be-tested time point; wherein the patching duration calculation formula is: wherein, the patching duration is, t 1 is a first period time point in the time parameters, t 2 is a second period time point in the time parameters, t n+1 N+1 is an N+1th period time point in the time parameters, t n N is an Nth period time point in the time parameters, t i the to-be-tested time point is.

2. The method of determining mean arterial pressure according to claim 1, characterized in that, The determination of the target time period corresponding to the to-be-measured time point according to the time parameter further comprises: if the to-be-measured time point is a periodic time point, determining a time period between an Nth periodic time point in the time parameter and the to-be-measured time point as the target time period corresponding to the to-be-measured time point. After the determination of whether the first time difference is less than the second time difference, the method further comprises: if the first time difference is greater than or equal to the second time difference, determining a time period between an Nth periodic time point in the time parameter and the to-be-measured time point as the target time period corresponding to the to-be-measured time point.

3. The method of determining mean arterial pressure according to claim 1, characterized in that, The periodic feature is diastolic pressure, systolic pressure, or dicrotic notch.

4. The method of determining mean arterial pressure according to claim 1, characterized in that, The pressure measurement data comprises a plurality of continuous blood pressure measurement values from the same measurement position. The blood pressure measurement values in the target time period are a plurality of blood pressure measurement values in the target time period. The determination of mean arterial pressure corresponding to the to-be-measured time point according to the blood pressure measurement values in the target time period comprises: calculating a mean value of the plurality of blood pressure measurement values in the target time period, and determining the mean value of the plurality of blood pressure measurement values in the target time period as the mean arterial pressure.

5. A device for determining mean arterial pressure, characterized in that The device is used to perform the method for determining mean arterial pressure according to any one of claims 1-4, and the device comprises: an acquisition module configured to acquire pressure measurement data, the pressure measurement data comprising a plurality of continuous blood pressure measurement values; The detection module is configured to perform periodic feature detection on the pressure measurement data to obtain a periodic feature detection result, wherein the periodic feature detection result comprises a periodic feature and a periodic time point, the periodic time point is a time point at which the periodic feature appears, a time difference between two adjacent periodic time points corresponds to a length of a cardiac cycle, and the periodic feature is a characteristic value that appears only once in a cardiac cycle. The first determination module is configured to determine a time parameter corresponding to the to-be-detected time point according to the periodic feature detection result and a preset number N of cycles, and determine a target time period corresponding to the to-be-detected time point according to the time parameter, wherein the time parameter comprises N+1 periodic time points that are earlier than the to-be-detected time point and closest to the to-be-detected time point, N is a natural number greater than or equal to 0, and the greater N is, the farther the periodic time points corresponding to N are from the to-be-detected time point. The screening module is configured to screen blood pressure measurement values in the target time period from the pressure measurement data. The second determination module is configured to determine mean arterial pressure corresponding to the to-be-detected time point according to the blood pressure measurement values in the target time period. The first determination module determines the target time period corresponding to the to-be-detected time point according to the time parameter in the following manner: If the to-be-detected time point is not a periodic time point, the first determination module calculates a first time difference between the to-be-detected time point and a first periodic time point in the time parameter, and a second time difference between the first periodic time point and a second periodic time point in the time parameter. The first determination module determines whether the first time difference is less than the second time difference. If the first time difference is less than the second time difference, a first time point is obtained by delaying an N+1th period time point in the time parameters by a patching duration, a time period between the first time point and the to-be-tested time point is determined as a target time period corresponding to the to-be-tested time point; wherein the patching duration calculation formula is: wherein, the patching duration is t 1 is a first period time point in the time parameters, t 2 is a second period time point in the time parameters, t n+1 N+1 is an N+1th period time point in the time parameters, t n N is an Nth period time point in the time parameters, t i the to-be-tested time point is 6. The apparatus for determining mean arterial pressure as claimed in claim 5, characterized in that The pressure measurement data comprises a plurality of continuous blood pressure measurement values from the same measurement position, the blood pressure measurement values in the target time period are a plurality of blood pressure measurement values in the target time period, and the second determination module comprises: The first calculation submodule is configured to calculate a mean value of the plurality of blood pressure measurement values in the target time period, and determine the mean value of the plurality of blood pressure measurement values in the target time period as the mean arterial pressure.

7. The apparatus for determining mean arterial pressure as claimed in claim 5, wherein, The pressure measurement data comprises a plurality of continuous first blood pressure measurement values positioned on a distal side of a target object and a plurality of continuous second blood pressure measurement values positioned on a proximal side of the target object, and the blood pressure measurement values in the target time period comprise a plurality of first blood pressure measurement values in the target time period and a plurality of second blood pressure measurement values in the target time period. The second determination module comprises: The second calculation submodule is configured to calculate a mean value of the plurality of first blood pressure measurement values in the target time period to obtain first mean arterial pressure corresponding to the to-be-detected time point, and calculate a mean value of the plurality of second blood pressure measurement values in the target time period to obtain second mean arterial pressure corresponding to the to-be-detected time point. The device further comprises: The third determination module is configured to determine target information according to the first mean arterial pressure and the second mean arterial pressure.

8. The apparatus for determining mean arterial pressure as claimed in claim 7, characterized in that, The target information is a blood flow reserve fraction, and the target object is a blood pressure measurement member. The third determination module determines the target information according to the first mean arterial pressure and the second mean arterial pressure in the following manner: calculating a ratio of the first mean arterial pressure to the second mean arterial pressure, and determining the ratio of the first mean arterial pressure to the second mean arterial pressure as the blood flow reserve fraction.

9. The apparatus for determining mean arterial pressure as claimed in claim 7, characterized in that, The target information is a position condition of a blood pump, and the target object is a pump shell of the blood pump. The third determining module determines the target information according to the first mean arterial pressure and the second mean arterial pressure in the following manner: calculating a ratio and / or difference of the second mean arterial pressure to the first mean arterial pressure; determining the position condition of the blood pump according to the ratio and / or difference of the second mean arterial pressure to the first mean arterial pressure.

10. The apparatus for determining mean arterial pressure as claimed in claim 7, characterized in that, The target information is a radio frequency ablation degree, and the target object is an ablation needle or a guide sheath for carrying the ablation needle. The third determining module determines the target information according to the first mean arterial pressure and the second mean arterial pressure in the following manner: calculating a ratio and / or difference of the first mean arterial pressure to the second mean arterial pressure, and determining the radio frequency ablation degree according to the ratio and / or difference of the first mean arterial pressure to the second mean arterial pressure.

11. An electronic device, comprising: The electronic device comprises: a memory storing executable program codes; a processor coupled with the memory; the processor invokes the executable program codes stored in the memory to execute the mean arterial pressure determination method according to any one of claims 1-4.

12. A computer-readable storage medium, characterized in that, The computer readable storage medium stores executable program codes, and the executable program codes, when invoked, are used to execute the mean arterial pressure determination method according to any one of claims 1-4.

13. A pressure measurement system, the system comprising: a pressure measuring device and a processing device; wherein, the pressure measuring device comprises: an elongated body; a pressure measuring unit arranged on the elongated body and configured to acquire pressure measuring data; the processing device comprises a communication interface, a memory and a processor; the communication interface is configured to realize data transmission between the processing device and the pressure measuring device; the memory is configured to store executable program codes; the processor is configured to invoke the executable program codes, and when the executable program codes are executed, the mean arterial pressure determination method according to any one of claims 1-4 is realized.

14. The pressure measurement system of claim 13, wherein, The processor is configured to invoke the executable program codes and further perform the following operations: the pressure measuring data comprises a plurality of continuous first blood pressure measuring values positioned at a distal side of a target object and a plurality of continuous second blood pressure measuring values positioned at a proximal side of the target object; the blood pressure measuring values in the target time period comprise a plurality of first blood pressure measuring values in the target time period and a plurality of second blood pressure measuring values in the target time period; the determination of the mean arterial pressure corresponding to the to-be-detected time point according to the blood pressure measuring values in the target time period comprises: calculating a mean value of the plurality of first blood pressure measuring values in the target time period to obtain a first mean arterial pressure corresponding to the to-be-detected time point; calculating a mean value of the plurality of second blood pressure measuring values in the target time period to obtain a second mean arterial pressure corresponding to the to-be-detected time point; the steps further comprise: Determine target information according to the first mean arterial pressure and the second mean arterial pressure.

15. A pressure gradient sensing system, the system comprising: A pressure sensing device and a processing device; The pressure sensing device comprises: An elongated body; A pressure measuring unit arranged on the elongated body, configured to acquire pressure measurement data, wherein the pressure measuring unit comprises a first pressure sensor and a second pressure sensor, the first pressure sensor and the second pressure sensor are arranged in an axial direction of the elongated body and the first pressure sensor is located at a distal side of the second pressure sensor; The processing device comprises a communication interface, a memory and a processor; The communication interface is configured to realize data transmission between the processing device and the pressure sensing device; The memory is configured to store executable program codes; The processor is configured to call the executable program codes, and when the executable program codes are executed, the processor is configured to execute the mean arterial pressure determination method according to any one of claims 1-4.

16. A blood pump system, comprising: A blood pump assembly and a processing device; The blood pump assembly comprises: A pump housing; A rotor arranged in the pump housing; A pressure measuring unit arranged on the pump housing, configured to acquire pressure measurement data, wherein the pressure measuring unit comprises a first pressure sensor and a second pressure sensor, the first pressure sensor and the second pressure sensor are arranged in an axial direction of the pump housing and the first pressure sensor is located at a distal side of the second pressure sensor; The processing device comprises a communication interface, a memory and a processor; The communication interface is configured to realize data transmission between the processing device and the blood pump assembly; The memory is configured to store executable program codes; The processor is configured to call the executable program codes, and when the executable program codes are executed, the processor is configured to execute the mean arterial pressure determination method according to any one of claims 1-4.

17. An ablation system comprising: An ablation device and a processing device; The ablation device comprises: A guide sheath in the shape of a hollow tube, and an ablation needle capable of moving axially in the guide sheath; A pressure measuring unit arranged on the guide sheath and / or the ablation needle, configured to acquire pressure measurement data, wherein the pressure measuring unit comprises a first pressure sensor and a second pressure sensor, the first pressure sensor and the second pressure sensor are arranged in an axial direction of the guide sheath / ablation needle and the first pressure sensor is located at a distal side of the second pressure sensor; The processing device comprises a communication interface, a memory and a processor; The communication interface is configured to realize data transmission between the processing device and the ablation device; The memory is configured to store executable program codes; The processor is configured to call the executable program codes, and when the executable program codes are executed, the processor is configured to execute the mean arterial pressure determination method according to any one of claims 1-4.

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