A Chinese medicine composition for treating neurovascular diseases and its preparation method

Abstract

The present invention relates to the technical field of pharmaceutical compositions, and in particular to a Chinese medicine composition for treating neurovascular diseases and a preparation method thereof. A Chinese medicine composition for treating neurovascular diseases is prepared from the following components by mass: 18-22 parts of Astragalus, 17-21 parts of Codonopsis, 17-21 parts of Notoginseng, 15-19 parts of Millettia, 13-17 parts of Achyranthes, 13-17 parts of Aconite, 11-15 parts of Polygonatum, 10-14 parts of Cinnamomum, 8-12 parts of Mulberry, 5-9 parts of Scutellaria, 3-7 parts of Rhizoma Anemarrhenae and 3-7 parts of Licorice. The drug formula of the present invention is rigorous, and a large amount of clinical data has been verified, and the efficacy is definite, and it is used to treat the symptoms of numbness, pain, insensitivity, soreness, muscle atrophy and the like in the limbs caused by diabetic peripheral neuropathy. All the medicines are used together, and qi and blood are treated at the same time, and both the symptoms and the root cause are treated, and it has the functions of invigorating qi, activating blood circulation, and dredge channels to relieve pain.

Description

Technical Field

[0001] The present invention relates to the technical field of pharmaceutical compositions, and in particular to a traditional Chinese medicine composition for treating neurovascular diseases and a preparation method thereof. Background Art

[0002] Diabetes is a group of metabolic diseases characterized by high blood sugar. High blood sugar is caused by defects in insulin secretion or its biological function, or both. Diabetes is a long-term high blood sugar that leads to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves.

[0003] Diabetic neuropathy is one of the most common chronic complications of diabetes. The lesions can affect both the central and peripheral nerves, with the latter being particularly common. Distal sensory neuropathy is the most common lesion, accounting for more than 50% of all diabetic neuropathy.

[0004] Diabetic neuropathy has extensive pathological changes, mainly affecting peripheral nerves, autonomic nerves, cranial nerves, and the brain and spinal cord may also be affected. Early manifestations are demyelination and axonal degeneration of nerve fibers. Schwann cell proliferation, as the disease progresses, manifests as axonal degeneration and disappearance of myelin fibers. At the same time as myelin fiber degeneration, there is the generation of regeneration plexus. As the lesion progresses, the density of the regeneration plexus decreases, suggesting an inappropriate repair. This phenomenon is especially common in T2 diabetes. Sometimes, the clinical data and electrophysiological examinations of diabetic neuropathy suggest chronic inflammatory demyelinating polyneuropathy, whose main changes are inflammatory infiltration, demyelination and axonal loss, which is difficult to distinguish from idiopathic CIDP. When the autonomic nerves are affected, the main manifestations are degeneration of visceral autonomic nerves and sympathetic ganglion cells. The manifestations of microvascular involvement are mainly endothelial cell hyperplasia, thickening of the vascular wall, narrowing of the lumen, hyalin degeneration, and a decrease in the number of capillaries. In severe cases, small blood vessel occlusion may occur. Brain lesions mainly affect cerebral blood vessels, making strokes more likely to occur, especially cerebral infarctions. Some patients may develop brain atrophy and cerebral sclerosis. Spinal cord lesions are mainly caused by damage to the posterior cord, which is mainly a degenerative change.

[0005] Currently, methylcobalamin tablets, vitamin B1, vitamin B6, adenosine triphosphate, coenzyme A, niacin, etc. are mostly used for treatment or prevention, but the side effects are large or the effects are not obvious. There are many Chinese herbal compound prescriptions that also claim to treat diabetic neuropathy, but most of them are slow to take effect or have not been verified. Therefore, there is an urgent need for a Chinese herbal composition for the treatment of neurovascular diseases. Summary of the invention

[0006] The purpose of the present invention is to provide a Chinese medicine composition for treating neurovascular diseases.

[0007] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0008] The present invention provides a traditional Chinese medicine composition for treating neurovascular diseases, which is prepared from the following components in parts by weight: 18-22 parts of astragalus, 17-21 parts of codonopsis, 17-21 parts of notoginseng, 15-19 parts of millettia reticulata, 13-17 parts of achyranthes, 13-17 parts of aconite, 11-15 parts of polygonatum, 10-14 parts of cassia twig, 8-12 parts of mulberry, 5-9 parts of scutellaria, 3-7 parts of anemarrhena and 3-7 parts of liquorice.

[0009] The present invention also provides a method for preparing the Chinese medicine composition for treating neurovascular diseases, comprising the following steps:

[0010] (1) Mix and grind astragalus, codonopsis, notoginseng, millet spatholobi, achyranthes, aconite, polygonatum, cinnamon twig, mulberry, scutellaria, anemarrhena and liquorice to obtain material 1;

[0011] (2) mixing material 1 with water and boiling, and filtering to obtain a filtrate;

[0012] (3) The filtrate is concentrated under reduced pressure to obtain an extract, and then dried.

[0013] Preferably, the material after grinding in step (1) is passed through a 40-60 mesh sieve, and the collected and screened components are material 1.

[0014] Preferably, the mass ratio of the material 1 to water in step (2) is 1:4-8.

[0015] Preferably, the decocting time in step (2) is 2 to 4 hours.

[0016] Preferably, step (3) is concentrated under reduced pressure to an extract having a relative density of 1.15 to 1.25 at 60°C.

[0017] Preferably, the drying temperature in step (3) is 55-65°C.

[0018] Preferably, the drying time in step (3) is 3 to 5 hours.

[0019] Compared with the prior art, the present invention has the following beneficial effects:

[0020] 1. The drug formula of the present invention is rigorous, and a large amount of clinical data has been verified, and the curative effect is definite, and it is used to treat the symptoms of numbness, pain, insensitivity, soreness, muscle atrophy and the like in the limbs caused by diabetic peripheral neuropathy. The combination of the drugs can treat both qi and blood, and treat both the symptoms and the root causes, and has the functions of invigorating qi, activating blood circulation, unblocking meridians and relieving pain.

[0021] 2. Diabetic vascular neuropathy is mostly caused by blood stasis caused by qi deficiency. Qi and yin deficiency will result in poor blood circulation. The composition of the present invention mainly replenishes qi and nourishes yin, promotes blood circulation and removes blood stasis, dredges collaterals and nourishes blood. Among them, astragalus has the effect of replenishing qi and promoting blood circulation, and combined with codonopsis, panax notoginseng and millettia reticulata, it further helps its effect of promoting blood circulation and dredges collaterals.

[0022] Achyranthes bidentata and cinnamon twig, as assistant drugs, can remove blood stasis, dredge menstruation, guide blood downward, warm and dredge meridians, and can guide all drugs to reach the whole body; Polygonatum odoratum can replenish qi and nourish yin, and can also help the main drug to further exert its efficacy.

[0023] Aconite dispels cold and relieves pain; mulberry replenishes blood and nourishes yin, clears fire and detoxifies, and stops bleeding; Anemarrhena asphodeloides clears heat and clears fire, nourishes yin and moistens dryness. As an adjuvant, it can relieve the patient's pain and make up for the patient's liver and kidney deficiency and loss of essence and blood caused by the disease; Scutellaria baicalensis clears heat and dries dampness, while liquorice replenishes qi, nourishes the middle, detoxifies, and plays a role in harmonizing all the medicines.

[0024] The relationship between monarch, minister, assistant and envoy of the composition of the present invention is summarized as follows:

[0025] Lord: Astragalus, Codonopsis, Panax notoginseng, Millettia reticulata;

[0026] Ministers: Achyranthes bidentata, cinnamon twig, polygonatum;

[0027] Auxiliary: mulberry, rhizoma anemarrhenae, rhizoma aconiti pulcherrimonis;

[0028] Ingredients: Scutellaria baicalensis, Licorice. DETAILED DESCRIPTION

[0029] The present invention provides a traditional Chinese medicine composition for treating neurovascular diseases, which is prepared from the following components in parts by weight: 18-22 parts of astragalus, 17-21 parts of codonopsis, 17-21 parts of notoginseng, 15-19 parts of millettia, 13-17 parts of achyranthes, 13-17 parts of aconite, 11-15 parts of polygonatum, 10-14 parts of cassia twig, 8-12 parts of mulberry, 5-9 parts of scutellaria, 3-7 parts of anemarrhena and 3-7 parts of liquorice; preferably, the composition is prepared from the following components in parts by weight: 19-21 parts of astragalus, 18-21 parts of codonopsis, 15-19 parts of millettia, 13-17 parts of achyranthes, 13-17 parts of aconite, 11-15 parts of polygonatum, 10-14 parts of cinnamon twig, 8-12 parts of mulberry, 5-9 parts of scutellaria, 3-7 parts of anemarrhena and 3-7 parts of liquorice. 0 parts, 18-20 parts of Panax notoginseng, 16-18 parts of Millettia spatholobi, 14-16 parts of Achyranthes bidentata, 14-16 parts of Aconite root, 12-14 parts of Polygonatum sibiricum, 11-13 parts of cinnamon twig, 9-11 parts of mulberries, 6-8 parts of Scutellaria baicalensis, 4-6 parts of Anemarrhena asphodeloides and 4-6 parts of Licorice; further preferably, it is prepared from the following components in parts by weight: 20 parts of Astragalus, 19 parts of Codonopsis pilosula, 19 parts of Panax notoginseng, 17 parts of Millettia spatholobi, 15 parts of Achyranthes bidentata, 15 parts of Aconite root, 13 parts of Polygonatum sibiricum, 12 parts of cinnamon twig, 10 parts of mulberries, 7 parts of Scutellaria baicalensis, 5 parts of Anemarrhena asphodeloides and 5 parts of Licorice.

[0030] The present invention also provides a method for preparing the Chinese medicine composition for treating neurovascular diseases, comprising the following steps:

[0031] (1) Mix and grind astragalus, codonopsis, notoginseng, millet spatholobi, achyranthes, aconite, polygonatum, cinnamon twig, mulberry, scutellaria, anemarrhena and liquorice to obtain material 1;

[0032] (2) mixing material 1 with water and boiling, and filtering to obtain a filtrate;

[0033] (3) The filtrate is concentrated under reduced pressure to obtain an extract, and then dried.

[0034] In the present invention, the material after grinding in step (1) is passed through a 40-60 mesh sieve, and the collected and screened components are material 1; preferably; more preferably; more preferably.

[0035] In the present invention, the mass ratio of the material 1 to water in step (2) is 1:4-8; preferably 1:5-7; and more preferably 1:6.

[0036] In the present invention, the decocting time in step (2) is 2 to 4 hours, preferably 3 hours.

[0037] In the present invention, step (3) is concentrated under reduced pressure to an extract having a relative density of 1.15 to 1.25 at 60° C., preferably 1.20.

[0038] In the present invention, the drying temperature in step (3) is 55-65°C, preferably 57-63°C, more preferably 59-61°C, and more preferably 60°C.

[0039] In the present invention, the drying time in step (3) is 3 to 5 hours, preferably 4 hours.

[0040] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0041] Example 1

[0042] A method for preparing a Chinese medicine composition for treating neurovascular diseases, comprising the following steps:

[0043] (1) 18 parts of Astragalus, 17 parts of Codonopsis, 17 parts of Panax notoginseng, 15 parts of Millettia, 13 parts of Achyranthes, 13 parts of Aconite, 11 parts of Polygonatum, 10 parts of Cinnamomum, 8 parts of Morus, 5 parts of Scutellaria, 3 parts of Anemarrhena and 3 parts of Licorice were mixed and ground, and the ground material was passed through a 40-mesh sieve, and the screened components were collected to obtain Material 1;

[0044] (2) Material 1 and water are mixed and boiled at a mass ratio of 1:4 for 2 h, and the filtrate is filtered to obtain a filtrate;

[0045] (3) The filtrate is concentrated under reduced pressure to an extract with a relative density of 1.15 at 60°C, and dried at 55°C for 3 hours to obtain Chinese medicine powder.

[0046] Example 2

[0047] A method for preparing a Chinese medicine composition for treating neurovascular diseases, comprising the following steps:

[0048] (1) Mix and grind 22 parts of Astragalus, 21 parts of Codonopsis, 21 parts of Panax notoginseng, 19 parts of Millettia, 17 parts of Achyranthes, 17 parts of Aconite, 15 parts of Polygonatum, 14 parts of Cinnamomum, 12 parts of Morus, 9 parts of Scutellaria, 7 parts of Anemarrhena and 7 parts of Licorice, and pass the ground material through a 60-mesh sieve, and collect and screen the components to obtain Material 1;

[0049] (2) Material 1 and water were mixed and boiled in a mass ratio of 1:8 for 4 hours, and the filtrate was filtered to obtain a filtrate;

[0050] (3) The filtrate is concentrated under reduced pressure to an extract with a relative density of 1.25 at 60°C, and dried at 65°C for 5 hours to obtain Chinese medicine powder.

[0051] Example 3

[0052] A method for preparing a Chinese medicine composition for treating neurovascular diseases, comprising the following steps:

[0053] (1) Mix and grind 20 parts of Astragalus, 19 parts of Codonopsis, 19 parts of Panax notoginseng, 17 parts of Millettia, 15 parts of Achyranthes, 15 parts of Aconite, 13 parts of Polygonatum, 12 parts of Cinnamomum, 10 parts of Morus, 7 parts of Scutellaria, 5 parts of Anemarrhena and 5 parts of Licorice, and pass the ground material through a 50-mesh sieve, and collect and screen the components to obtain Material 1;

[0054] (2) Material 1 and water were mixed and boiled at a mass ratio of 1:6 for 3 h, and the filtrate was filtered to obtain a filtrate;

[0055] (3) The filtrate is concentrated under reduced pressure to an extract with a relative density of 1.2 at 60°C, and dried at 60°C for 4 hours to obtain Chinese medicine powder.

[0056] Experimental Example 1

[0057] 1. Case selection: 90 patients with diabetes and peripheral neurovascular disease were selected and divided into three groups, 30 in each group, with a male to female ratio of 1:1.

[0058] 2. Criteria for determining efficacy:

[0059] 1) Peripheral neuropathy: A. Significantly effective: clinical symptoms disappeared, and deep and superficial sensations and knee tendon reflexes basically returned to normal; B. Effective: clinical symptoms were alleviated, but deep and superficial sensations and knee tendon reflexes were not fully recovered; C. Ineffective: clinical symptoms and signs did not improve significantly.

[0060] 2) Peripheral vascular disease: A. Significantly effective: The pulsation of the dorsalis pedis artery was significantly enhanced, the skin temperature returned to normal, and the clinical symptoms disappeared; B. Effective: The pulsation of the dorsalis pedis artery was enhanced, the temperature of the foot returned to normal, and the clinical symptoms basically disappeared; C. Ineffective: There was no significant improvement in clinical symptoms and signs.

[0061] 3. Medication:

[0062] The Chinese medicine powder obtained in Example 3 was used as the experimental group; 5 g each time, once in the morning and once in the evening.

[0063] The control group took methylcobalamin according to the instructions.

[0064] Blank control group: no drug was used.

[0065] The experiment lasted for 14 days as one course of treatment, and a total of 6 courses of treatment were carried out. After the second course of treatment, the fourth course of treatment and the completion of the experiment, the treatment effect of each experimental group was statistically analyzed, and the results are shown in Table 1.

[0066] Table 1

[0067]

[0068]

[0069] As shown in Table 1, after 6 courses of treatment, the experimental group had the best effect, with a cure rate of 83.3%. The therapeutic effect of the drug on diabetic neurovascular lesions is excellent, and is significantly better than the therapeutic effect of drugs in the prior art by 60%.

[0070] Experimental Example 2

[0071] Typical Cases

[0072] 1. Hu, male, has diabetes for 6 years, neuropathy in both feet, almost no feeling in both feet, muscle atrophy, long-term treatment with lipoic acid, and insulin injection, but poor therapeutic effect. After taking the Chinese medicine powder of the present invention for 3 courses, the symptoms were significantly relieved, and both feet began to feel. After taking 7 courses, the symptoms basically disappeared, and the feeling of both feet was basically restored.

[0073] 2. Li, female, had diabetes for 11 years, type 2 diabetes, diabetic peripheral neuropathy, symptoms of dry mouth, weakness in the limbs, tingling in the hands and feet, and decreased sensation. After taking the Chinese medicine powder of the present invention for 5 courses of treatment, the tingling in the hands and feet was relieved, and there was no abnormality in sensation.

[0074] 3. Xie, male, had diabetes for 4 years and diabetic peripheral neuropathy for 1 year. His feet were numb and cold, and he had hypoesthesia. His feet had mild pitting edema and slight tingling. After taking the Chinese medicine powder of the present invention for 6 courses of treatment, his symptoms disappeared, his limbs felt normal, and the tingling sensation disappeared.

[0075] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating neurovascular diseases, characterized in that: The invention is prepared from the following components in parts by weight: 18-22 parts of astragalus, 17-21 parts of codonopsis, 17-21 parts of panax notoginseng, 15-19 parts of millettia reticulata, 13-17 parts of achyranthes bidentata, 13-17 parts of aconite, 11-15 parts of polygonatum, 10-14 parts of cinnamon twig, 8-12 parts of mulberry, 5-9 parts of scutellaria, 3-7 parts of anemarrhena and 3-7 parts of liquorice.

2. The method for preparing a Chinese medicine composition for treating neurovascular diseases according to claim 1, characterized in that: The steps include: (1) Mix and grind astragalus, codonopsis, notoginseng, millet spatholobi, achyranthes, aconite, polygonatum, cinnamon twig, mulberry, scutellaria, anemarrhena and liquorice to obtain material 1; (2) Mix material 1 with water, boil the mixture, and filter to obtain a filtrate; (3) The filtrate is concentrated under reduced pressure to obtain an extract and then dried.

3. The method for preparing a Chinese medicine composition for treating neurovascular diseases according to claim 2, characterized in that: The ground material in step (1) is passed through a 40-60 mesh sieve, and the screened components are collected as material 1.

4. The method for preparing a Chinese medicine composition for treating neurovascular diseases according to claim 2, characterized in that: In step (2), the mass ratio of material 1 to water is 1:4-8.

5. The method for preparing a Chinese medicine composition for treating neurovascular diseases according to claim 2, characterized in that: The decoction time in step (2) is 2 to 4 hours.

6. The method for preparing a Chinese medicine composition for treating neurovascular diseases according to claim 2, characterized in that: Step (3) is concentrated under reduced pressure to an extract having a relative density of 1.15 to 1.25 at 60°C.

7. The method for preparing a Chinese medicine composition for treating neurovascular diseases according to claim 2, characterized in that: The drying temperature in step (3) is 55-65°C.

8. The method for preparing a Chinese medicine composition for treating neurovascular diseases according to claim 2, characterized in that: The drying time in step (3) is 3 to 5 hours.

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