A liposome of robenacoxib and a preparation method and application thereof

By encapsulating robecoxib in a phospholipid bilayer using liposome technology, the problem of frequent administration of robecoxib in veterinary medicine is solved, achieving long-acting sustained-release drug delivery and improving drug solubility and duration of action in vivo.

CN117281778BActive Publication Date: 2026-06-09CHINA AGRI UNIV
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Patent Information

Application Number
CN202311431325.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-10-31
Publication Date
2026-06-09
Estimated Expiration
2043-10-31

AI Technical Summary

Technical Problem

Existing robecoxib drugs require frequent administration in veterinary medicine to achieve a long-lasting analgesic effect, and have a short half-life in the body, affecting the convenience of use.

Method used

Robecoxib liposomes were prepared by encapsulating robecoxib in a phospholipid bilayer using liposome technology. By optimizing the ratio of phospholipids, cholesterol, and PEGylated phospholipids, and combining it with high-pressure homogenization technology, the encapsulation efficiency and drug loading of the drug were improved.

Benefits of technology

This improved the solubility and duration of action of robecoxib in vivo, reduced the frequency of administration, and enabled long-acting sustained-release drug delivery.

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Abstract

The present application relates to a kind of robecoxib liposome and its preparation method and application, the preparation raw material of the robecoxib liposome includes phospholipid, cholesterol and robecoxib, and the robecoxib is encapsulated in lipid bilayer, and the robecoxib liposome of the present application improves the solubility of robecoxib, and has higher encapsulation efficiency and drug loading.
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Citation Information

Patent Citations

  • Preparation method of robecoxib

    CN111807978A

  • Robecoxib intermediate and synthesis method of Robecoxib

    CN115433117A