Guilong Kechuanning tablets and preparation method thereof

Abstract

The invention relates to the technical field of preparation of traditional Chinese medicine preparations, and particularly discloses a preparation method of Guilong Kechuanning tablets. The Guilong Kechuanning tablets comprise the following components in parts by weight: 86 parts of cinnamon twigs, 172 parts of dragon bones, 86 parts of white peony roots, 86 parts of ginger, 86 parts of jujubes, 52 parts of roasted licorice roots, 172 parts of oysters, 18 parts of coptis chinensis, 78 parts of pinellia tubers, 86 parts of trichosanthes peels, and 78 parts of bitter almonds. The preparation method comprises the following steps: grinding 86 parts of dried cinnamon twigs and 42 parts of white peony roots into fine powder; combining 44 parts of white peony roots with other components, performing water extraction and concentration to obtain a clear paste; mixing the clear paste with porous starch, adding the fine powder, mixing evenly, and drying under reduced pressure; successively adding povidone K30 and magnesium stearate, mixing evenly, tableting, and coating to obtain the Guilong Kechuanning tablets. The preparation method of the Guilong Kechuanning tablets of the present invention can improve the mixing uniformity of ingredients and the powder fluidity through porous starch, and the pressed tablets have smooth tablet surfaces, small tablet weight differences, high hardness, low friability, rapid disintegration, and high tablet quality.

Description

Technical Field

[0001] The present invention relates to the technical field of preparation of traditional Chinese medicine preparations, in particular to a Guilong Kechuanning tablet and a preparation method thereof. Background Art

[0002] Guilong Kechuanning Tablets are a compound Chinese patent medicine preparation containing eleven herbs including cinnamon twig, dragon bone, white peony root, etc. It has the effects of relieving cough and phlegm, lowering qi and relieving asthma. It is used to treat cough, asthma, and excessive phlegm caused by exogenous wind-cold, phlegm and dampness blocking the lungs, as well as acute and chronic bronchitis.

[0003] Guilong Kechuanning tablets are produced in tablet form, which have the advantages of convenient storage, relatively accurate dosage, relatively stable quality, and easy production. Chinese patent application publication number CN 113117039 A discloses a method for preparing Guilong Kechuanning tablets. The preparation process includes mixing a viscous liquid paste with other powder materials (medicinal powder, starch, etc.), then wet-granulating the mixture in a swing granulator to form wet granules, drying the mixture, adding the dried mixture to the swing granulator for granulation, and then adding magnesium stearate for mixing. The mixture is then tableted and coated. The above preparation process is relatively complex. During the mixing and granulation of the viscous liquid paste with other powder materials and the drying process, problems such as uneven material mixing, material wall loss, poor granule formation, loose granules, and unqualified particle size may occur, which is not conducive to the subsequent tableting and coating processes. Direct tableting is the process of directly mixing the drug and all excipients without granulating the powder and then pressing the tablets. The direct tableting method has the advantages of fewer steps, simple process, and reduced energy consumption, but it has defects such as poor powder fluidity, large differences in tablet weight, easy cracking, and chipping. Summary of the Invention

[0004] In view of the above shortcomings, the present invention provides a Guilong Kechuanning tablet and a preparation method thereof, which has a relatively simple process and high tablet quality; the specific technical solution is as follows:

[0005] A preparation method of Guilong Kechuanning tablets, comprising the following components in parts by weight: 86 parts of cinnamon twigs, 172 parts of dragon bones, 86 parts of white peony root, 86 parts of ginger, 86 parts of jujube, 52 parts of roasted licorice root, 172 parts of oysters, 18 parts of coptis root, 78 parts of pinellia tuber, 86 parts of trichosanthes peel, and 78 parts of bitter almonds (fried). The preparation method comprises the following steps:

[0006] (1) Grind 86 parts of dried cinnamon twig and 42 parts of white peony root into fine powder;

[0007] (2) 44 parts of white peony root were combined with the remaining components for water extraction, and concentrated under reduced pressure to obtain a clear paste;

[0008] (3) mixing the clear paste obtained in step (2) with porous starch, adding the fine powder obtained in step (1) and mixing, drying under reduced pressure, grinding into fine powder, adding povidone K30 and magnesium stearate successively and mixing to obtain a mixed powder;

[0009] (4) The mixed powder obtained in step (3) is tableted and coated to obtain Guilong Kechuanning tablets.

[0010] In the present invention, porous starch is added and mixed with the clear paste, so that the effective ingredients in the clear paste can be absorbed, the ingredients can be mixed evenly, and the tablet has good fluidity, and can be directly tableted, which simplifies the preparation process. The combination of povidone K30 and magnesium stearate adjuvants can make the tablet surface smooth, which is more conducive to improving the process qualification rate. The tablets have good hardness and low friability.

[0011] Preferably, in the preparation method of the above-mentioned Guilong Kechuanning tablets, in the step (1), the raw medicinal materials of cinnamon twig and white peony root are respectively cleaned and moistened, cut into thin slices with a thickness of 1 to 2 mm, and the slices are frozen at -18 to -20°C for 5 to 8 hours, and then vacuum freeze-dried for 5 to 10 hours, and then pulverized into fine powder, and the particle size of the fine powder is controlled to be less than 50 μm. The prior art discloses a three-step drying process of hot air circulation drying-reduced pressure drying-freeze drying for medicinal materials. In this drying process, the first hot air circulation drying will harden the medicinal materials and reduce the loosening effect of the medicinal materials after subsequent freeze drying; in the present invention, the medicinal material slices are first pre-frozen and then vacuum freeze-dried, which can make the medicinal materials looser and more porous, which is conducive to the release of effective ingredients and better promotes the absorption of ingredients; and the fine powder particle size is controlled to be more refined, which is conducive to the mixing of materials.

[0012] Preferably, in the preparation method of the above-mentioned Guilong Kechuanning tablets, in the step (2), water extraction is performed three times, the first time with 8 times water for 2 hours, the second time with 6 times water for 1 hour, and the third time with 6 times water for 0.5 hours. The extracts are combined and concentrated under reduced pressure to a relative density of 1.25 to 1.28 to obtain a clear paste.

[0013] Preferably, in the preparation method of the above-mentioned Guilong Kechuanning tablets, the preparation method of the porous starch comprises the following steps:

[0014] S1. The starch and buffer solution were mixed, and then nano-silica was added and stirred at 500-600 r / min for 0.5-1h, and ultrasonicated for 15-20min. The amount of the nano-silica added was 1.5-3% by weight of the starch to obtain a mixed suspension;

[0015] S2. Adding a complex enzyme to the mixed suspension obtained in step S1, reacting at 40-50°C for 3-5 hours, and then adding alkali to terminate the reaction; collecting the precipitate by centrifugation, washing the precipitate, freeze-drying it, and grinding it to obtain porous starch. Adding silicon dioxide to the starch to prepare the porous starch facilitates the formation of a stable porous structure and improves the performance of the porous starch.

[0016] Preferably, in the preparation method of the above-mentioned Guilong Kechuanning tablets, the compound enzyme is a mixture of saccharifying enzyme and α-amylase in a volume ratio of 2:1 to 4:1, and the saccharifying enzyme activity is 10 5 u / ml, and the α-amylase activity was 4000u / ml.

[0017] Preferably, in the preparation method of the above-mentioned Guilong Kechuanning tablets, 0.01 to 0.025 ml of the complex enzyme is added per gram of starch.

[0018] Preferably, in the preparation method of the above-mentioned Guilong Kechuanning tablets, the buffer solution is disodium hydrogen phosphate-citrate buffer or sodium acetate buffer, the pH of the buffer solution is 4.5-6.5, and the ratio of starch to buffer solution is 1g:10ml-20ml.

[0019] Preferably, in the preparation method of the above-mentioned Guilong Kechuanning tablets, the reduced pressure drying temperature is 50-60° C., and the vacuum degree is less than -0.05 MPa.

[0020] Preferably, in the preparation method of the above-mentioned Guilong Kechuanning tablets, in the step (3), the weight parts of porous starch are 65-75 parts, povidone K30 is 4-5 parts, and magnesium stearate is 1-2 parts.

[0021] A Guilong Kechuanning tablet is prepared by the above-mentioned preparation method.

[0022] Compared with the prior art, the present invention has the following beneficial effects:

[0023] 1. The preparation method of the Guilong Kechuanning tablets of the present invention simplifies the preparation process. By adding porous starch, the uniformity of ingredient mixing and powder fluidity can be improved. The tablets can be used for direct tableting. The tablets pressed out have a smooth and beautiful surface, small tablet weight difference, high hardness, low friability, and rapid disintegration. The problems of cracking and chipping are solved, and the tablets are of high quality.

[0024] 2. The preparation method of the Guilong Kechuanning tablets of the present invention comprises the following steps: adding silicon dioxide to starch to prepare porous starch, which is conducive to forming a stable porous structure and improving the use effect of the porous starch; mixing the porous starch with the clear paste can absorb the effective ingredients in the clear paste, so that the ingredients are mixed evenly and have good fluidity; combining with povidone K30 and magnesium stearate adjuvants can make the tableting surface smooth, the tablets have good hardness and low friability, and the process qualification rate is improved. DETAILED DESCRIPTION

[0025] The specific embodiments of the present invention are described in detail below, but it should be understood that the scope of protection of the present invention is not limited by the specific embodiments. Unless otherwise defined, all technical terms used hereinafter have the same meaning as those generally understood by those skilled in the art. The technical terms used herein are only for the purpose of describing specific embodiments and are not intended to limit the scope of protection of the present invention. Unless otherwise specified, the various raw materials, reagents, instruments and equipment used in the present invention can be purchased from the market or can be prepared by existing methods.

[0026] The medicinal materials used in the following examples and comparative examples were all pre-treated to prepare Guilong Kechuanning tablets, and the pre-treatment was specifically as follows:

[0027] Cassia twig: Pick and remove impurities, weigh, wash with drinking water, soak thoroughly, slice and set aside.

[0028] White Peony Root: Select and remove impurities, weigh, wash with drinking water, soak thoroughly, slice, use one part for feeding, and the other part for making fine powder.

[0029] Dragon bones: Pick out impurities, wash with drinking water, smash into pieces and set aside.

[0030] Ginger: Pick and remove impurities, wash with drinking water, soak thoroughly, slice and set aside.

[0031] Jujube: Pick and remove impurities, wash with drinking water, break open and set aside.

[0032] Roasted licorice root: select and remove impurities, wash with drinking water, moisten thoroughly, slice, place in a hot air circulation oven below 80℃ to dry, weigh, add 25% honey of the medicinal material, prepare, fry until yellow to dark yellow, take out when it is no longer sticky, let cool, and set aside.

[0033] Oysters: sort and remove impurities, weigh, wash with drinking water, dry in a hot air circulation oven below 80°C, grind and crush, and set aside.

[0034] Coptis chinensis: Pick and remove impurities, wash with drinking water, soak thoroughly, slice and set aside.

[0035] Trichosanthes peel: Pick out impurities, wash with drinking water, dry slightly, soak thoroughly, cut into shreds, and set aside.

[0036] French Pinellia: Pick and remove impurities, wash with drinking water, slice, stir-fry and set aside.

[0037] Stir-fry bitter almonds: select and remove impurities, wash with drinking water, place in a hot air circulation oven below 60℃ to dry, process, stir-fry until the surface is slightly bulging, slightly yellow in color, with burnt spots, take out and let cool, grind and crush, and set aside.

[0038] Example 1

[0039] A Guilong Kechuanning tablet comprises the following components, measured by weight: 86 parts of cinnamon twig, 172 parts of dragon bone, 86 parts of white peony root, 86 parts of ginger, 86 parts of jujube, 52 parts of roasted liquorice root, 172 parts of oyster, 18 parts of coptis root, 78 parts of pinellia tuber, 86 parts of trichosanthes peel, and 78 parts of bitter almond (fried).

[0040] A preparation method of Guilong Kechuanning tablets comprises the following steps:

[0041] (1) Wash and moisten the cinnamon twig and white peony root, cut them into slices with a thickness of 1 to 2 mm, freeze the slices at -20°C for 5 h, and then freeze-dry them in a vacuum (-25°C, vacuum degree -0.01 MPa) for 8 h to obtain dried cinnamon twig and white peony root. Take 86 parts of the dried cinnamon twig and 42 parts of the dried white peony root, grind them into fine powder, and pass them through a 300-mesh sieve to a particle size of less than 50 μm.

[0042] (2) 44 parts of white peony root were combined with the remaining components and added to an extraction tank for water extraction three times, the first time with 8 times water for 2 hours, the second time with 6 times water for 1 hour, and the third time with 6 times water for 0.5 hours. The extracts were combined and concentrated under reduced pressure to a relative density of 1.26 (60°C) to obtain a clear paste;

[0043] (3) The clear paste obtained in step (2) and 72 parts of porous starch were stirred and mixed in a trough mixer for 30 minutes, and the fine powder obtained in step (1) was added and continued to be stirred and mixed for 30 minutes, and then dried under reduced pressure at a temperature of 55° C., a vacuum degree of -0.055 MPa, and a moisture content of 4-5%. The mixture was then pulverized into fine powder, and 4 parts of povidone K30 and 1.5 parts of magnesium stearate were added and mixed to obtain a mixed powder;

[0044] (4) using a tablet press to compress the mixed powder obtained in step (3) into plain tablets, and using a high-efficiency coating machine to perform film coating to obtain Guilong Kechuanning tablets.

[0045] The preparation method of porous starch comprises the following steps:

[0046] S1. Corn starch and buffer solution were mixed at a ratio of 1 g:15 ml of starch and buffer solution, and the buffer solution was acetic acid sodium acetate buffer (pH 5). Then, 2% nano-silica by weight of starch was added and stirred at 500 r / min for 1 h. Ultrasonic dispersion was performed for 15 min at an ultrasonic frequency of 20 kHz to obtain a mixed suspension.

[0047] S2. Adding a complex enzyme to the mixed suspension obtained in step (1), the complex enzyme is a saccharifying enzyme and α-amylase mixed in a volume ratio of 2.5:1, adding 0.02 ml of complex enzyme per gram of starch, and the saccharifying enzyme activity is 10 5 u / ml, and the α-amylase activity was 4000 u / ml; after reacting at 45°C for 4 hours, alkali was added to terminate the reaction; the precipitate was collected by centrifugation, washed 3 times with deionized water, freeze-dried at -30°C, ground, and passed through a 200-mesh sieve to obtain porous starch.

[0048] Example 2

[0049] A Guilong Kechuanning tablet comprises the following components, measured by weight: 86 parts of cinnamon twig, 172 parts of dragon bone, 86 parts of white peony root, 86 parts of ginger, 86 parts of jujube, 52 parts of roasted liquorice root, 172 parts of oyster, 18 parts of coptis root, 78 parts of pinellia tuber, 86 parts of trichosanthes peel, and 78 parts of bitter almond (fried).

[0050] A preparation method of Guilong Kechuanning tablets comprises the following steps:

[0051] (1) Wash and moisten the cinnamon twig and white peony root, cut them into slices with a thickness of 1 to 2 mm, freeze the slices at -20°C for 5 h, and then freeze-dry them in a vacuum (-25°C, vacuum degree -0.01 MPa) for 8 h to obtain dried cinnamon twig and white peony root. Take 86 parts of the dried cinnamon twig and 42 parts of the dried white peony root, grind them into fine powder, and pass them through a 300-mesh sieve to a particle size of less than 50 μm.

[0052] (2) 44 parts of white peony root were combined with the remaining components and added to an extraction tank for water extraction three times, the first time with 8 times the water for 2 hours, the second time with 6 times the water for 1 hour, and the third time with 6 times the water for 0.5 hours. The extracts were combined and concentrated under reduced pressure to a relative density of 1.26 (60°C) to obtain a clear paste;

[0053] (3) The clear paste obtained in step (2) and 68 parts of porous starch were stirred and mixed in a trough mixer for 30 minutes, and the fine powder obtained in step (1) was added and continued to be stirred and mixed for 30 minutes, and then dried under reduced pressure at a temperature of 55° C., a vacuum degree of -0.055 MPa, and a moisture content of 4-5%. The mixture was then pulverized into fine powder, and 5 parts of povidone K30 and 1 part of magnesium stearate were added and mixed to obtain a mixed powder;

[0054] (4) using a tablet press to compress the mixed powder obtained in step (3) into plain tablets, and using a high-efficiency coating machine to perform film coating to obtain Guilong Kechuanning tablets.

[0055] The preparation method of porous starch comprises the following steps:

[0056] S1. Corn starch and buffer solution were mixed at a ratio of 1 g:15 ml of starch and buffer solution, and the buffer solution was acetic acid sodium acetate buffer (pH 5). Then, 2.5% nano-silica by weight of starch was added and stirred at 500 r / min for 1 h. Ultrasonic dispersion was performed for 15 min at an ultrasonic frequency of 20 kHz to obtain a mixed suspension.

[0057] S2. Adding a complex enzyme to the mixed suspension obtained in step (1), the complex enzyme is a saccharifying enzyme and α-amylase mixed in a volume ratio of 3:1, adding 0.018 ml of complex enzyme per gram of starch, and the saccharifying enzyme activity is 10 5 u / ml, and the α-amylase activity was 4000 u / ml; after reacting at 45°C for 4 hours, alkali was added to terminate the reaction; the precipitate was collected by centrifugation, washed 3 times with deionized water, freeze-dried at -30°C, ground, and passed through a 200-mesh sieve to obtain porous starch.

[0058] Comparative Example 1

[0059] The difference between this comparative example and Example 1 is that: Step (1) the washed and moistened cinnamon twigs and white peony root are cut into slices with a thickness of 1 to 2 mm, and the cinnamon twig slices are dried as follows: primary drying: placing them in a hot air circulation oven for oven drying for 1 hour, with the drying temperature controlled at 75°C; then naturally cooling to room temperature; secondary drying: placing the cinnamon twig slices that have been dried once in a vacuum drying oven for reduced pressure drying for 1 hour, with the drying temperature controlled at 55°C and the vacuum degree at -0.05MPa; then naturally cooling to room temperature; tertiary drying: placing the cinnamon twig slices that have been dried twice in a vacuum drying oven for reduced pressure drying for 1 hour, with the drying temperature controlled at 55°C and the vacuum degree at -0.05MPa; then naturally cooling to room temperature; The steps of drying the white peony slices in a freeze dryer for 1 hour at a drying temperature of 0°C were as follows: drying the white peony slices in a hot air circulation oven for 1 hour at a drying temperature of 75°C; and then naturally cooling the slices to room temperature; and drying the white peony slices in a freeze dryer for 1 hour at a drying temperature of 1°C to obtain dry white peony slices. 86 parts of the dried cinnamon twigs and 42 parts of the white peony slices were pulverized into fine powder, which was sieved through a 300-mesh sieve to obtain a particle size of less than 50 μm. The other steps and parameters were the same as those in Example 1.

[0060] Comparative Example 2

[0061] This comparative example differs from Example 1 in that in step (3), porous starch is directly replaced by starch raw material; other steps and parameters are the same as those in Example 1.

[0062] Comparative Example 3

[0063] This comparative example differs from Example 1 in that nano-silicon dioxide is not added in the preparation of porous starch; other steps and parameters are the same as those in Example 1.

[0064] Comparative Example 4

[0065] This comparative example differs from Example 1 in that: nano-silicon dioxide is not added in the preparation of porous starch; in step (3), 72 parts of porous starch are stirred and added together in a trough mixer, and the amount of nano-silicon dioxide added is 2% of the weight of the corn starch used to prepare the porous starch; the other steps and parameters are the same as those in Example 1.

[0066] Examples 1 to 2 and Comparative Examples 1 to 4 were made into tablets of the same size and specifications, and the performance indicators of the tablets were examined.

[0067] Tablet weight difference detection method: Take 20 tablets, accurately weigh the total weight, calculate the average tablet weight, then accurately weigh each tablet separately, and compare the weight of each tablet with the average tablet weight.

[0068] Friability: Check with reference to the tablet friability test method (General Rule 0923) in the Pharmacopoeia of the People's Republic of China.

[0069] Hardness: Use a tablet hardness tester to test. Place the tablet in the fixture of the hardness tester and gradually apply pressure until the tablet breaks.

[0070] The disintegration time is checked with reference to the disintegration time test method (General Rule 0921) in the Pharmacopoeia of the People's Republic of China.

[0071] Determination of cinnamic acid content: Determined by high performance liquid chromatography (Chinese Pharmacopoeia 2015 edition, Part IV, General Chapter 0512).

[0072] Chromatographic conditions and system suitability test: Use octadecylsilane bonded silica gel as the filler; acetonitrile-0.5% phosphoric acid solution (30:70) as the mobile phase; detection wavelength at 270 nm. The theoretical plate number calculated based on the cinnamic acid peak should be no less than 3000.

[0073] Preparation of reference solution: Accurately weigh 10 mg of cinnamic acid reference substance that has been dried to constant weight under reduced pressure over phosphorus pentoxide, place it in a 100 ml brown volumetric flask, add 50% methanol to dissolve and dilute to the scale, shake well, accurately measure 1 ml, place it in a 10 ml brown volumetric flask, add 50% methanol to dilute to the scale, shake well, and obtain (each 1 ml contains 10 μg of cinnamic acid).

[0074] Preparation of test solution: Take 10 tablets of this product, remove the coating, grind into powder, take 1g, accurately weigh, place in a 100ml brown volumetric flask, accurately add 50ml of 50% methanol, weigh the weight, ultrasonically treat (power 250W, frequency 40kHz) for 30 minutes, let cool, weigh the weight again, make up the lost weight with 50% methanol, shake well, filter, and take the filtrate.

[0075] Determination method: Accurately aspirate 5-10 μl of reference solution and test solution respectively, inject into liquid chromatograph, and determine.

[0076] The results are shown in Table 1. As can be seen from the table, the addition of porous starch in the present invention can improve the quality of tablets, with small tablet weight differences, good hardness and low friability, rapid disintegration, and no cracking or chipping.

[0077] Table 1 Performance test indicators of each group of tablets

[0078]

[0079] The foregoing descriptions of specific exemplary embodiments of the present invention are for purposes of illustration and description. These descriptions are not intended to limit the invention to the precise forms disclosed, and it is apparent that many variations and modifications are possible in light of the foregoing teachings. The exemplary embodiments have been selected and described for the purpose of explaining the specific principles of the invention and their practical application, thereby enabling those skilled in the art to realize and utilize a variety of exemplary embodiments of the invention and various options and modifications. The scope of the invention is intended to be defined by the claims and their equivalents.

Claims

1. A method for preparing Guilong Kechuanning tablets, characterized in that: The Guilong Kechuanning tablets comprise the following components by weight: 86 parts of cinnamon twigs, 172 parts of dragon bones, 86 parts of white peony root, 86 parts of ginger, 86 parts of jujube, 52 parts of roasted licorice root, 172 parts of oysters, 18 parts of coptis root, 78 parts of pinellia tuber, 86 parts of trichosanthes peel, and 78 parts of bitter almonds. The preparation method comprises the following steps: (1) Grind 86 parts of dried cinnamon twig and 42 parts of white peony root into fine powder; (2) 44 parts of white peony root were combined with the remaining components for water extraction, and concentrated under reduced pressure to obtain a clear paste; (3) The clear paste obtained in step (2) is mixed evenly with the porous starch, and then the fine powder obtained in step (1) is added and mixed evenly, followed by drying under reduced pressure, crushing into fine powder, and successively adding povidone K30 and magnesium stearate and mixing evenly to obtain a mixed powder; (4) tableting and coating the mixed powder obtained in step (3) to obtain Guilong Kechuanning tablets; The preparation method of the porous starch comprises the following steps: S1. The starch and buffer solution were mixed, and then nano-silica was added and stirred at 500~600r / min for 0.5~1h, ultrasonicated for 15~20min, the amount of the nano-silica added was 1.5~3% by weight of the starch to obtain a mixed suspension; S2. Adding a complex enzyme to the mixed suspension obtained in step S1, reacting at 40-50°C for 3-5 hours, and then adding alkali to terminate the reaction; collecting the precipitate by centrifugation, washing the precipitate, freeze-drying, and grinding to obtain porous starch.

2. The preparation method of Guilong Kechuanning tablets according to claim 1, characterized in that In the step (1), the raw medicinal materials of cinnamon twig and white peony root are respectively washed and moistened, cut into slices with a thickness of 1 to 2 mm, frozen at -18 to -20°C for 5 to 8 hours, then vacuum freeze-dried for 5 to 10 hours, and then pulverized into fine powder, with the particle size of the fine powder controlled to be less than 50 μm.

3. The preparation method of Guilong Kechuanning tablets according to claim 1, characterized in that: In the step (2), water extraction is performed three times, the first time with 8 times water for 2 hours, the second time with 6 times water for 1 hour, and the third time with 6 times water for 0.5 hours. The extracts are combined and concentrated under reduced pressure to a relative density of 1.25 to 1.28 to obtain a clear paste.

4. The preparation method of Guilong Kechuanning tablets according to claim 1, characterized in that: The compound enzyme is a mixture of saccharifying enzyme and α-amylase in a volume ratio of 2:1 to 4:1, and the activity of the saccharifying enzyme is 10 5 u / ml, and the α-amylase activity was 4000u / ml.

5. The preparation method of Guilong Kechuanning tablets according to claim 4, characterized in that: 0.01-0.025 ml of the complex enzyme is added per gram of starch.

6. The preparation method of Guilong Kechuanning tablets according to claim 1, characterized in that: The buffer solution is a disodium hydrogen phosphate-citric acid buffer or an acetic acid sodium acetate buffer, the pH of the buffer solution is 4.5-6.5, and the ratio of the starch to the buffer solution is 1g:10ml-20ml.

7. The preparation method of Guilong Kechuanning tablets according to claim 1, characterized in that: The reduced pressure drying temperature is 50~60℃ and the vacuum degree is less than -0.05MPa.

8. A Guilong Kechuanning tablet, characterized in that: The Guilong Kechuanning tablets are prepared by the preparation method according to any one of claims 1 to 7.

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