A kind of atomization breathing drug delivery device

Abstract

The present invention relates to the technical field of atomizing drug delivery devices, and in particular to an atomizing breathing drug delivery device. The device comprises an oxygen source, an atomizer, a humidifier and a controller. The present invention generates a high-speed airflow through oxygen drive to excite the humidifying liquid into microparticles or mist particles suspended together with the atomized drug particles in the inhalation airflow to enter the airway, and in the drug delivery process, the user's real-time blood oxygen saturation, real-time cough times and real-time cough frequency are monitored to analyze the impact of the atomizing breathing drug delivery device on the user. If the drug delivery quality of the atomizing breathing drug delivery device is low, that is, the airway humidification is insufficient, or the humidifying liquid is not fully heated, the wet and cold atomized gas directly stimulates the respiratory mucosa to increase the burden on the bronchus, thereby stimulating the user to cough, which will increase the severity of the cough. Therefore, by analyzing the cough characteristics, the humidification state of the supplied drug is adjusted to ensure the drug delivery quality and airway humidification effect.

Description

Technical Field

[0001] The invention relates to the technical field of atomizing drug delivery devices, and in particular to an atomizing breathing drug delivery device. Background Art

[0002] Nebulizer inhalation therapy is one of the effective options for treating respiratory diseases. It has become the preferred drug delivery route for the treatment of asthma, chronic obstructive pulmonary disease and cystic fibrosis. Tracheotomy is an important method for neurosurgery patients to solve airway obstruction and improve ventilation and oxygenation. Medical nebulizers are commonly used respiratory disease treatment equipment. Nebulizers atomize liquid medicine into tiny particles. The drugs enter the respiratory tract and are deposited in the lungs by inhalation, thus achieving painless, rapid and effective treatment. At present, small-capacity nebulizers are often used in respiratory treatment. When using it, first pour the medicine into the medicine cup, tighten the cup lid, and after the nebulizer produces mist, the patient opens his mouth to inhale the medicine. According to the characteristics and working principles of the nebulizer, the nebulizers commonly used to treat children with respiratory diseases can be divided into ultrasonic nebulizers and pressure jet nebulizers. There are three types of nebulizers: vibrating mesh nebulizer; during the use of nebulizer by patients with tracheotomy, the gas loses its function of warming, humidifying and filtering the upper respiratory tract after tracheotomy. The use of dry gas and dehydrating agent leads to dry respiratory mucosa, viscous sputum, damaged cilia, and easy formation of sputum plugs to block the airway. If the patient cannot be properly fixed due to impaired consciousness, excessive loss of humidification liquid will be caused. Repeated addition of humidification liquid will increase the risk of contamination and the workload of nurses. Nebulization and oxygen therapy need to be interrupted during sputum suction, which brings great inconvenience to the patients. Airway humidification can make the cilia of the airway wall move actively, and cooperate with postural drainage and vibration expectoration to make the sputum cough up and ensure effective gas exchange. Therefore, there is an urgent need for a patient nebulization drug delivery device that can meet the oxygen supply demand and ensure the effect of airway humidification while the patient is undergoing nebulization treatment.

[0003] Chinese Patent Publication No.: CN114534026A discloses a medical nebulization breathing drug delivery device, the technical point of which is to realize the atomization of the drug solution by driving the atomization core to vibrate through a piezoelectric ceramic sleeve, and to obtain an excellent drug atomization effect by cooperating with the further collision and cutting action of the grid grid, and to heat the drug solution through the vibration action at the same time; it can be seen that in the existing atomization drug delivery device technology, there is a lack of an intelligent atomization drug delivery device, which can not only meet the oxygen supply demand while the patient is undergoing atomization treatment, but also can adapt to and adjust the oxygen supply flow rate and the humidification state of the supplied drug according to the patient's ventilation characteristics, thereby improving the comfort of the device and ensuring the humidification effect of the airway. Summary of the invention

[0004] To this end, the present invention provides an atomizing breathing drug delivery device to overcome the problem in the prior art that the humidification state of the supplied drug is difficult to ensure the humidification effect of the airway, resulting in low quality of the supplied drug.

[0005] To achieve the above object, the present invention provides an atomizing breathing drug delivery device, comprising:

[0006] An oxygen source is used to generate an air flow discharged to the atomizer, and a gas supply valve is also provided on one side of the oxygen source to control the flow or disconnection of oxygen;

[0007] A nebulizer, one side of which is connected to the oxygen source, so as to allow oxygen to pass through the liquid medicine contained therein to convert the liquid medicine into aerosolized medicine particles;

[0008] A humidifier connected to the nebulizer, comprising a liquid storage tank for containing humidifying liquid, an infusion pump for pumping the humidifying liquid into the nebulizer, and a heating mechanism for adjusting the temperature of the liquid storage tank, wherein the humidifier is used to humidify the atomized drug particles to form a supply drug;

[0009] A breathing detection instrument is used to detect the user's real-time blood oxygen saturation, real-time coughing times, and single coughing duration;

[0010] A controller is connected to the air supply valve, the infusion pump, the breathing detection instrument and the heating mechanism respectively; the controller determines the real-time blood oxygen saturation difference according to the set standard blood oxygen saturation range, wherein:

[0011] If the real-time blood oxygen saturation difference is greater than the first standard blood oxygen saturation difference and less than or equal to the second standard blood oxygen saturation difference and the real-time blood oxygen saturation is less than or equal to the second standard blood oxygen saturation, the controller will control the air supply valve to adjust the initial oxygen supply flow rate;

[0012] If the real-time blood oxygen saturation difference is greater than the first standard blood oxygen saturation difference and is less than or equal to the second standard blood oxygen saturation difference and the real-time blood oxygen saturation is greater than the second standard blood oxygen saturation, the controller determines the real-time number of coughs according to the standard cough number range, and when it is determined that there is a single cough duration greater than or equal to the standard single cough duration, calculates the real-time cough frequency according to the single cough duration, and determines the real-time cough frequency according to the standard cough frequency, so as to adjust the initial pumping power of the infusion pump or the real-time humidification temperature of the liquid storage tank.

[0013] Further, the controller obtains the real-time blood oxygen saturation of the user terminal detected by the breathing detection instrument, calculates the real-time blood oxygen saturation difference according to the standard blood oxygen saturation and the real-time blood oxygen saturation, and determines the real-time blood oxygen saturation difference according to the first standard blood oxygen saturation difference.

[0014] If the real-time blood oxygen saturation difference is less than or equal to the first standard blood oxygen saturation difference, the air supply valve is not controlled to adjust the initial oxygen concentration;

[0015] If the real-time blood oxygen saturation difference is greater than the first standard blood oxygen saturation difference, the real-time blood oxygen saturation difference will be judged according to the second standard blood oxygen saturation difference to determine whether to issue an early warning prompt.

[0016] Furthermore, when the controller determines that the real-time blood oxygen saturation difference is greater than the first standard blood oxygen saturation difference, the controller determines the real-time blood oxygen saturation difference according to the second standard blood oxygen saturation difference.

[0017] If the real-time blood oxygen saturation difference is less than or equal to the second standard blood oxygen saturation difference, the real-time blood oxygen saturation will be judged according to the second standard blood oxygen saturation to determine whether to control the air supply valve to adjust the initial oxygen supply flow rate;

[0018] If the real-time blood oxygen saturation difference is greater than the second standard blood oxygen saturation difference, an early warning will be issued.

[0019] Furthermore, the controller determines the real-time blood oxygen saturation difference according to the second standard blood oxygen saturation when determining that the real-time blood oxygen saturation difference is less than or equal to the second standard blood oxygen saturation difference.

[0020] If the real-time blood oxygen saturation is less than or equal to the second standard blood oxygen saturation, the controller will control the air supply valve to adjust the initial oxygen supply flow rate;

[0021] If the real-time blood oxygen saturation is greater than the second standard blood oxygen saturation, the real-time cough number will be judged according to the standard cough number to determine the humidification state of the supplied medicine.

[0022] Furthermore, when the controller determines that the real-time blood oxygen saturation is greater than the second standard blood oxygen saturation, the controller obtains the real-time coughing number detected by the respiratory detection instrument, and determines the real-time coughing number according to the first standard coughing number and the second standard coughing number.

[0023] If the real-time coughing number is less than the first standard coughing number, it is determined that the humidification state of the supplied medicine is normal;

[0024] If the real-time cough number is between the first standard cough number and the second standard cough number, the duration of each single cough is determined according to the standard single cough duration to adjust the humidification state of the supplied medicine;

[0025] If the real-time coughing number is greater than the second standard coughing number, the real-time respiratory frequency difference is judged according to the standard respiratory frequency difference to determine whether to stop atomization.

[0026] Furthermore, when the controller determines that the real-time coughing number is between the first standard coughing number and the second standard coughing number, the controller obtains the duration of each single cough detected by the respiratory detection instrument, and determines the duration of each single cough according to the standard single cough duration.

[0027] If there is a single cough duration that is greater than or equal to the standard single cough duration, the real-time cough frequency is determined according to the standard cough frequency to determine the method of adjusting the humidification state of the supplied medicine;

[0028] If the duration of a single cough is less than the standard duration of a single cough, the initial pumping power of the infusion pump is adjusted according to the real-time number of coughs to a first corrected pumping power;

[0029] Wherein, Pc1'=Pc×[1+(Ns-Nb1) / Ns], Pc1' represents the adjusted first corrected pumping power, Pc represents the initial pumping power, Nb1 represents the first standard cough number, and Ns represents the real-time cough number.

[0030] Furthermore, when the controller determines that the duration of a single cough is greater than or equal to the standard duration of a single cough, the controller calculates the real-time cough frequency according to the detection data of the respiratory detection instrument, and determines the real-time cough frequency according to the standard cough frequency.

[0031] If the real-time cough frequency is less than or equal to the standard cough frequency, adjusting the initial pumping power of the infusion pump according to the real-time cough frequency to a second corrected pumping power;

[0032] If the real-time cough frequency is greater than the standard cough frequency, adjusting the real-time humidification temperature of the liquid storage tank according to the real-time cough frequency to a first corrected humidification temperature;

[0033] Among them, Pc2'=Pc×[1+(Mb-Ms) / Ms], Ts1'=Ts×[1+(Ms-Mb) / Ms], Ts1' represents the adjusted second corrected humidification temperature, Ts represents the real-time humidification temperature, Pc2' represents the adjusted second corrected pumping power, Pc represents the initial pumping power, Mb represents the standard cough frequency, and Ms represents the real-time cough number.

[0034] Furthermore, the controller calculates the real-time cough frequency based on the detection data of the respiratory detection instrument. When it is determined that the duration of a single cough is greater than or equal to the standard duration of a single cough, the corresponding cough behavior is marked as a differential cough, and the number of differential coughs within each preset monitoring time detected by the respiratory detection instrument is obtained respectively, and the number of differential coughs within each preset monitoring time is divided by the preset monitoring time to obtain the corresponding real-time cough frequency.

[0035] Further, when the controller determines that the real-time coughing number is greater than the second standard coughing number, the controller calculates the real-time respiratory frequency difference according to the standard respiratory frequency and the real-time respiratory frequency based on the real-time respiratory frequency of the user terminal detected by the respiratory detection instrument, and determines the real-time respiratory frequency difference according to the standard respiratory frequency difference.

[0036] If the real-time respiratory frequency difference is less than or equal to the standard respiratory frequency difference, adjusting the real-time humidification temperature of the liquid storage tank according to the real-time coughing number to a second corrected humidification temperature;

[0037] If the real-time respiratory rate difference is greater than the standard respiratory rate difference, atomization is stopped and an early warning prompt is issued;

[0038] Wherein, Ts2'=Ts×[1+(Ns-Nb2) / Ns], Ts2' represents the adjusted second corrected humidification temperature, Ts represents the real-time humidification temperature, Nb2 represents the second standard cough number, and Ns represents the real-time cough number.

[0039] Furthermore, the controller can adjust the initial oxygen supply flow rate according to the real-time blood oxygen saturation detected by the breathing detection instrument. When the controller determines that the real-time blood oxygen saturation is less than or equal to the second standard blood oxygen saturation, the controller controls the air supply valve to adjust the initial oxygen supply flow rate to the corrected oxygen supply flow rate;

[0040] Among them, Qc'=Qc×[1+(Fb2-Fs) / Fs], Qc' represents the adjusted corrected oxygen supply flow rate, Qc represents the initial oxygen supply flow rate, Fb2 represents the second standard blood oxygen saturation, and Fs represents the real-time blood oxygen saturation.

[0041] Compared with the prior art, the beneficial effect of the present invention lies in that the humidification liquid is excited into microparticles or mist particles suspended in the inhaled airflow by oxygen drive, and enters the airway together with the atomized drug particles in the inhaled airflow. During the drug administration process, the user's real-time blood oxygen saturation, real-time cough times, and real-time cough frequency are monitored to analyze the impact of the atomizing breathing drug administration device on the user. If the drug administration quality of the atomizing breathing drug administration device is low, that is, the airway humidification is insufficient, or the humidification liquid is not fully heated, the wet and cold atomized gas directly stimulates the respiratory mucosa and increases the burden on the bronchus, thereby stimulating the user to cough, which will increase the severity of the cough. Therefore, by analyzing the cough characteristics, the humidification state of the supplied drug can be adjusted to ensure the drug administration quality and airway humidification effect.

[0042] Furthermore, by applying the nebulizer breathing drug delivery device to patients with impaired consciousness, the blood oxygen saturation decreases due to the ventilation dysfunction of the body caused by the sputum before the user suctions the sputum. Therefore, when the blood oxygen saturation is low, that is, when the real-time blood oxygen saturation is determined to be less than or equal to the second standard blood oxygen saturation, the oxygen supply flow rate is increased in time to increase the oxygen concentration, ensure sufficient oxygen supply, and improve the comfort of the device.

[0043] In particular, by determining that the duration of a single cough is shorter than the standard duration of a single cough, it indicates that the irritating cough caused by the nebulizing breathing drug delivery device to the user has little impact, and the initial pumping power of the infusion pump can be adjusted to ensure that the amount of humidification liquid is sufficient.

[0044] Furthermore, when it is determined that the duration of a single cough is greater than or equal to the standard duration of a single cough, the cough characteristics are analyzed to accurately adjust the humidification state of the supplied medicine. If it is determined that the real-time cough frequency is less than or equal to the standard cough frequency, it means that the irritating cough caused by the nebulizer breathing drug delivery device to the user has little effect. The initial pumping power of the infusion pump is adjusted to ensure sufficient humidification liquid. If it is determined that the real-time cough frequency is greater than the standard cough frequency, it means that the airway humidification is still insufficient and the humidification liquid heating is not yet sufficient, resulting in more severe irritating coughs occurring frequently. The humidification liquid temperature is heated to avoid irritation to the respiratory mucosa caused by the wet and cold nebulized gas, reduce irritation to the user, and ensure the quality of drug delivery and airway humidification effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0045] Figure 1 This is a schematic diagram of the structure of the atomizing breathing drug delivery device according to an embodiment of the present invention;

[0046] Figure 2 A logic decision diagram for adjusting the initial oxygen supply flow rate according to an embodiment of the present invention;

[0047] Figure 3 A logic determination diagram for determining whether the humidification state of the supplied medicine is normal according to an embodiment of the present invention;

[0048] Figure 4 This is a logic decision diagram for adjusting the humidification state according to an embodiment of the present invention. DETAILED DESCRIPTION

[0049] In order to make the objects and advantages of the present invention more clearly understood, the present invention is further described below in conjunction with embodiments; it should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0050] The preferred embodiments of the present invention are described below with reference to the accompanying drawings. It should be understood by those skilled in the art that these embodiments are only used to explain the technical principles of the present invention and are not intended to limit the protection scope of the present invention.

[0051] It should be noted that, in the description of the present invention, terms such as "up", "down", "left", "right", "inside" and "outside" indicating directions or positional relationships are based on the directions or positional relationships shown in the drawings. This is merely for the convenience of description and does not indicate or imply that the device or element must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it cannot be understood as a limitation on the present invention.

[0052] In addition, it should be noted that in the description of the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For those skilled in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0053] See also Figure 1 As shown, it is a schematic diagram of the structure of the atomizing breathing drug administration device according to an embodiment of the present invention. The present invention provides an atomizing breathing drug administration device, including an oxygen source 1, a compressor 101, an atomizer 2, a humidifier 3, a liquid storage tank 301, an infusion pump 302, a heating mechanism 303, a breathing detection instrument (not shown in the figure) and a controller (not shown in the figure), wherein:

[0054] An oxygen source, one side of which is provided with a compressor for generating an air flow discharged to the atomizer, and one side of which is also provided with an air supply valve for controlling the flow or disconnection of oxygen;

[0055] A nebulizer, one side of which is connected to the oxygen source, so as to allow oxygen to pass through the liquid medicine contained therein to convert the liquid medicine into aerosolized medicine particles;

[0056] A humidifier connected to the nebulizer, comprising a liquid storage tank for containing humidifying liquid, an infusion pump for pumping the humidifying liquid into the nebulizer, and a heating mechanism for adjusting the temperature of the liquid storage tank, wherein the humidifier is used to humidify the atomized drug particles to form a supply drug;

[0057] A breathing detection instrument is used to detect the user's real-time blood oxygen saturation, real-time coughing times, and single coughing duration;

[0058] A controller is connected to the air supply valve, the infusion pump, the breathing detection instrument and the heating mechanism respectively; the controller determines the real-time blood oxygen saturation difference according to the set standard blood oxygen saturation range, wherein:

[0059] If the real-time blood oxygen saturation difference is greater than the first standard blood oxygen saturation difference and less than or equal to the second standard blood oxygen saturation difference and the real-time blood oxygen saturation is less than or equal to the second standard blood oxygen saturation, the controller will control the air supply valve to adjust the initial oxygen supply flow rate;

[0060] If the real-time blood oxygen saturation difference is greater than the first standard blood oxygen saturation difference and is less than or equal to the second standard blood oxygen saturation difference and the real-time blood oxygen saturation is greater than the second standard blood oxygen saturation, the controller determines the real-time number of coughs according to the standard cough number range, and when it is determined that there is a single cough duration greater than or equal to the standard single cough duration, calculates the real-time cough frequency according to the single cough duration, and determines the real-time cough frequency according to the standard cough frequency, so as to adjust the initial pumping power of the infusion pump or the real-time humidification temperature of the liquid storage tank.

[0061] In this embodiment, a high-speed airflow is generated by oxygen drive to excite the humidification liquid into microparticles or mist particles suspended in the inhaled airflow and enter the airway together with the atomized drug particles. During the drug administration process, the user's real-time blood oxygen saturation, real-time cough times, and real-time cough frequency are monitored to analyze the impact of the atomizing breathing drug administration device on the user. If the drug administration quality of the atomizing breathing drug administration device is low, that is, the airway humidification is insufficient, or the humidification liquid is not fully heated, the wet and cold atomized gas directly stimulates the respiratory mucosa and increases the burden on the bronchus, thereby stimulating the user to cough, which will increase the severity of the cough. Therefore, the cough characteristics are analyzed to adjust the humidification state of the supplied drug to ensure the drug administration quality and airway humidification effect.

[0062] Specifically, the controller is provided with a standard blood oxygen saturation and a first standard blood oxygen saturation difference, the controller obtains the real-time blood oxygen saturation of the user end detected by the respiratory detection instrument, calculates the real-time blood oxygen saturation difference according to the standard blood oxygen saturation and the real-time blood oxygen saturation, and determines the real-time blood oxygen saturation difference according to the first standard blood oxygen saturation difference.

[0063] If the real-time blood oxygen saturation difference is less than or equal to the first standard blood oxygen saturation difference, the air supply valve is not controlled to adjust the initial oxygen concentration;

[0064] If the real-time blood oxygen saturation difference is greater than the first standard blood oxygen saturation difference, the real-time blood oxygen saturation difference will be judged according to the second standard blood oxygen saturation difference to determine whether to issue an early warning prompt.

[0065] The standard blood oxygen saturation set in this embodiment is an indicator to measure the oxygen content in human blood, expressed as a percentage, representing an indicator of the combination of red blood cells and oxygen in the blood, that is, the ratio of oxygen to hemoglobin. The standard blood oxygen saturation is set to 94%. The higher the value, the healthier the human body. The lower the blood oxygen saturation, the signs of various health problems. Therefore, it is used in various medical health tests, especially respiratory problems. The first standard blood oxygen saturation difference is set to 3%. Within this range, due to errors, it can also represent normal blood oxygen saturation; if the blood oxygen saturation is lower than 90%, it is generally believed that the human health is poor and the vital signs are more dangerous. Therefore, the second standard blood oxygen saturation difference is set to 4%, and the second standard blood oxygen saturation is 90%. The human vital signs can be accurately monitored by monitoring the blood oxygen level; the real-time blood oxygen saturation is measured using an oximeter, and the reading can be directly read;

[0066] Specifically, a second standard blood oxygen saturation difference is set in the controller. When the controller determines that the real-time blood oxygen saturation difference is greater than the first standard blood oxygen saturation difference, the real-time blood oxygen saturation difference is determined according to the second standard blood oxygen saturation difference.

[0067] If the real-time blood oxygen saturation difference is less than or equal to the second standard blood oxygen saturation difference, the real-time blood oxygen saturation will be judged according to the second standard blood oxygen saturation to determine whether to control the air supply valve to adjust the initial oxygen supply flow rate;

[0068] If the real-time blood oxygen saturation difference is greater than the second standard blood oxygen saturation difference, an early warning will be issued.

[0069] See also Figure 2 As shown, it is a logic determination diagram for adjusting the initial oxygen supply flow rate according to an embodiment of the present invention;

[0070] Specifically, the controller determines the real-time blood oxygen saturation difference is less than or equal to the second standard blood oxygen saturation difference, and determines the real-time blood oxygen saturation according to the second standard blood oxygen saturation.

[0071] If the real-time blood oxygen saturation is less than or equal to the second standard blood oxygen saturation, the controller will control the air supply valve to adjust the initial oxygen supply flow rate;

[0072] If the real-time blood oxygen saturation is greater than the second standard blood oxygen saturation, the real-time cough number will be judged according to the standard cough number to determine the humidification state of the supplied medicine.

[0073] The nebulizer breathing drug delivery device in this embodiment is applied to patients with impaired consciousness. Since the user's sputum before suctioning causes ventilation dysfunction of the body and a decrease in blood oxygen saturation occurs, when the blood oxygen saturation is low, that is, when the real-time blood oxygen saturation is determined to be less than or equal to the second standard blood oxygen saturation, the oxygen supply flow rate is increased in time to increase the oxygen concentration, ensure sufficient oxygen supply, and improve the comfort of the device.

[0074] See also Figure 3 As shown, it is a logic determination diagram for determining whether the humidification state of the supplied medicine is normal according to an embodiment of the present invention;

[0075] Specifically, the controller is provided with a first standard cough number and a second standard cough number. When the controller determines that the real-time blood oxygen saturation is greater than the second standard blood oxygen saturation, the controller obtains the real-time cough number detected by the respiratory detection instrument, and determines the real-time cough number according to the first standard cough number and the second standard cough number.

[0076] If the real-time coughing number is less than the first standard coughing number, it is determined that the humidification state of the supplied medicine is normal;

[0077] If the real-time cough number is between the first standard cough number and the second standard cough number, the duration of each single cough is determined according to the standard single cough duration to adjust the humidification state of the supplied medicine;

[0078] If the real-time coughing number is greater than the second standard coughing number, the real-time respiratory frequency difference is judged according to the standard respiratory frequency difference to determine whether to stop atomization.

[0079] The first standard cough number and the second standard cough number set in this embodiment are related to the user's physical condition and disease type. The first standard cough number indicates the number of coughs of the user when the nebulizer breathing drug delivery device is not used. Generally, the first standard cough number is set at 1-2 times, and the second standard cough number is set at 8-9 times. If the airway is not humidified enough during nebulizer drug delivery, it will cause irritating coughs in the user. Therefore, by monitoring the user's cough number, the drug supply status can be adjusted in real time to ensure effective airway humidification, thereby improving the quality of drug supply.

[0080] If it is determined that the real-time cough number is less than the first standard cough number, it means that the nebulizer breathing drug delivery device is adapted to the user. If it is determined that the real-time cough number is between the first standard cough number and the second standard cough number, it means that the user's coughing frequency has increased. This is caused by the low drug delivery quality of the nebulizer breathing drug delivery device, and the humidification state of the supplied drug needs to be adjusted. If it is determined that the real-time cough number is greater than the second standard cough number, it means that the user coughs more frequently. If the user has shortness of breath or unstable vital signs, nebulization needs to be stopped in time, and medical staff will provide corresponding measures.

[0081] See also Figure 4 As shown, it is a logic decision diagram for adjusting the humidification state according to an embodiment of the present invention;

[0082] Specifically, a standard single cough duration is set in the controller. When the controller determines that the real-time cough number is between the first standard cough number and the second standard cough number, the controller obtains the duration of each single cough detected by the respiratory detection instrument, and determines the duration of each single cough according to the standard single cough duration.

[0083] If there is a single cough duration that is greater than or equal to the standard single cough duration, the real-time cough frequency is determined according to the standard cough frequency to determine the method of adjusting the humidification state of the supplied medicine;

[0084] If the duration of a single cough is less than the standard duration of a single cough, the initial pumping power of the infusion pump is adjusted according to the real-time number of coughs to a first corrected pumping power;

[0085] Wherein, Pc1'=Pc×[1+(Ns-Nb1) / Ns], Pc1' represents the adjusted first corrected pumping power, Pc represents the initial pumping power, Nb1 represents the first standard cough number, and Ns represents the real-time cough number.

[0086] The standard single cough duration set in this embodiment indicates the length of time a cough lasts, characterizing the severity and nature of the cough. The set value is related to the user's age, health status, and cause of the cough. Generally, it is set between 1s and 5s. For example, a cough with a shorter duration is caused by a mild cold, while a cough with a longer duration is caused by respiratory tract infection, asthma and other diseases. If the drug delivery quality of the nebulizer respiratory drug delivery device is low, that is, the airway humidification is insufficient, or the humidification liquid is not fully heated, the wet and cold nebulized gas directly stimulates the respiratory mucosa to increase the burden on the bronchus, thereby stimulating the user to cough, which will increase the severity of the cough. Therefore, the cough characteristics are analyzed to adjust the humidification state of the supplied drug.

[0087] By determining that the duration of a single cough is shorter than the standard duration of a single cough, it indicates that the irritating cough caused by the nebulizer breathing drug delivery device to the user has little effect. Then, the initial pumping power of the infusion pump can be adjusted to ensure that the amount of humidification liquid is sufficient.

[0088] Specifically, a standard cough frequency is set in the controller. When it is determined that the duration of a single cough is greater than or equal to the standard single cough duration, the controller calculates the real-time cough frequency according to the detection data of the respiratory detection instrument, and determines the real-time cough frequency according to the standard cough frequency.

[0089] If the real-time cough frequency is less than or equal to the standard cough frequency, adjusting the initial pumping power of the infusion pump according to the real-time cough frequency to a second corrected pumping power;

[0090] If the real-time cough frequency is greater than the standard cough frequency, adjusting the real-time humidification temperature of the liquid storage tank according to the real-time cough frequency to a first corrected humidification temperature;

[0091] Among them, Pc2'=Pc×[1+(Mb-Ms) / Ms], Ts1'=Ts×[1+(Ms-Mb) / Ms], Ts1' represents the adjusted second corrected humidification temperature, Ts represents the real-time humidification temperature, Pc2' represents the adjusted second corrected pumping power, Pc represents the initial pumping power, Mb represents the standard cough frequency, and Ms represents the real-time cough number.

[0092] The standard cough frequency set in this embodiment represents the number of irritating coughs caused to the user by the nebulizer breathing drug delivery device within the preset monitoring time. The set value is related to the user's age, health status, cause of cough, and preset monitoring time. Generally, the set value is 1 time per minute, and is adjusted according to the user's age, health status, and cause of cough.

[0093] When it is determined that the duration of a single cough is greater than or equal to the standard duration of a single cough, the cough characteristics are analyzed to accurately adjust the humidification state of the supplied medicine. If the real-time cough frequency is determined to be less than or equal to the standard cough frequency, it means that the irritating cough caused by the nebulizer breathing drug delivery device has little effect on the user. In this case, the initial pumping power of the infusion pump is adjusted to ensure sufficient humidification liquid. If the real-time cough frequency is determined to be greater than the standard cough frequency, it means that the airway humidification is not sufficient and the humidification liquid heating is not sufficient, resulting in more severe irritating coughs occurring frequently. In this case, the humidification liquid temperature is heated to avoid irritation of the respiratory mucosa caused by the wet and cold nebulized gas, reduce irritation to the user, and ensure the drug delivery quality and airway humidification effect.

[0094] Specifically, a preset monitoring duration is set in the controller, and the controller calculates the real-time cough frequency according to the detection data of the respiratory detection instrument. When it is determined that the single cough duration is greater than or equal to the standard single cough duration, the corresponding cough behavior is marked as a differential cough, and the number of differential coughs within each preset monitoring duration detected by the respiratory detection instrument is obtained respectively, and the number of differential coughs within each preset monitoring duration is divided by the preset monitoring duration to obtain the corresponding real-time cough frequency.

[0095] The preset monitoring time set in this embodiment is between 10 minutes and 20 minutes, which can be adjusted according to the user's nebulization drug delivery needs, and will not be described in detail here.

[0096] Specifically, the controller is set with a standard respiratory frequency and a standard respiratory frequency difference. When the controller determines that the real-time coughing number is greater than the second standard coughing number, the controller calculates the real-time respiratory frequency difference according to the real-time respiratory frequency of the user terminal detected by the respiratory detection instrument, according to the standard respiratory frequency and the real-time respiratory frequency, and determines the real-time respiratory frequency difference according to the standard respiratory frequency difference.

[0097] If the real-time respiratory frequency difference is less than or equal to the standard respiratory frequency difference, adjusting the real-time humidification temperature of the liquid storage tank according to the real-time coughing number to a second corrected humidification temperature;

[0098] If the real-time respiratory rate difference is greater than the standard respiratory rate difference, atomization is stopped and an early warning prompt is issued;

[0099] Wherein, Ts2'=Ts×[1+(Ns-Nb2) / Ns], Ts2' represents the adjusted second corrected humidification temperature, Ts represents the real-time humidification temperature, Nb2 represents the second standard cough number, and Ns represents the real-time cough number.

[0100] The standard respiratory rate set in this embodiment represents a normal respiratory rate indicator, which is related to the user's gender, age, and physical condition. The standard respiratory rate difference is represented by a set smaller respiratory rate fluctuation range, which is generally set to 10-15 times / minute. The standard respiratory rate and the standard respiratory rate difference constitute the standard respiratory rate range. If the real-time respiratory rate difference is greater than the standard respiratory rate difference, it means that the user has shortness of breath and unstable vital signs, then it is necessary to stop nebulization in time, and the medical staff provide corresponding measures.

[0101] Specifically, the controller is provided with an initial oxygen supply flow rate, and the controller can adjust the initial oxygen supply flow rate according to the real-time blood oxygen saturation detected by the respiratory detection instrument. When the controller determines that the real-time blood oxygen saturation is less than or equal to the second standard blood oxygen saturation, the controller controls the air supply valve to adjust the initial oxygen supply flow rate to the corrected oxygen supply flow rate;

[0102] Among them, Qc'=Qc×[1+(Fb2-Fs) / Fs], Qc' represents the adjusted corrected oxygen supply flow rate, Qc represents the initial oxygen supply flow rate, Fb2 represents the second standard blood oxygen saturation, and Fs represents the real-time blood oxygen saturation.

[0103] So far, the technical solutions of the present invention have been described in conjunction with the preferred embodiments shown in the accompanying drawings. However, it is easy for those skilled in the art to understand that the protection scope of the present invention is obviously not limited to these specific embodiments. Without departing from the principle of the present invention, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions after these changes or substitutions will fall within the protection scope of the present invention.

[0104] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A nebulizing breathing drug delivery device, characterized in that: include, An oxygen source is used to generate an air flow discharged to the atomizer, and a gas supply valve is also provided on one side of the oxygen source to control the flow or disconnection of oxygen; A nebulizer, one side of which is connected to the oxygen source, so as to allow oxygen to pass through the liquid medicine contained therein to convert the liquid medicine into aerosolized medicine particles; A humidifier connected to the nebulizer, comprising a liquid storage tank for containing humidifying liquid, an infusion pump for pumping the humidifying liquid into the nebulizer, and a heating mechanism for adjusting the temperature of the liquid storage tank, wherein the humidifier is used to humidify the atomized drug particles to form a supply drug; A breathing detection instrument is used to detect the user's real-time blood oxygen saturation, real-time coughing times, and single coughing duration; A controller is connected to the air supply valve, the infusion pump, the breathing detection instrument and the heating mechanism respectively; the controller determines the real-time blood oxygen saturation difference according to the set standard blood oxygen saturation range, wherein: If the real-time blood oxygen saturation difference is greater than the first standard blood oxygen saturation difference and less than or equal to the second standard blood oxygen saturation difference and the real-time blood oxygen saturation is less than or equal to the second standard blood oxygen saturation, the controller will control the air supply valve to adjust the initial oxygen supply flow rate; If the real-time blood oxygen saturation difference is greater than the first standard blood oxygen saturation difference and is less than or equal to the second standard blood oxygen saturation difference and the real-time blood oxygen saturation is greater than the second standard blood oxygen saturation, the controller determines the real-time number of coughs according to the standard cough number range, and when it is determined that there is a single cough duration greater than or equal to the standard single cough duration, calculates the real-time cough frequency according to the single cough duration, and determines the real-time cough frequency according to the standard cough frequency, so as to adjust the initial pumping power of the infusion pump or the real-time humidification temperature of the liquid storage tank.

2. The atomizing breathing drug delivery device according to claim 1, characterized in that: The controller obtains the real-time blood oxygen saturation of the user terminal detected by the breathing detection instrument, calculates the real-time blood oxygen saturation difference according to the standard blood oxygen saturation and the real-time blood oxygen saturation, and determines the real-time blood oxygen saturation difference according to the first standard blood oxygen saturation difference. If the real-time blood oxygen saturation difference is less than or equal to the first standard blood oxygen saturation difference, the air supply valve is not controlled to adjust the initial oxygen concentration; If the real-time blood oxygen saturation difference is greater than the first standard blood oxygen saturation difference, the real-time blood oxygen saturation difference will be judged according to the second standard blood oxygen saturation difference to determine whether to issue an early warning prompt.

3. The atomizing breathing drug delivery device according to claim 2, characterized in that: When the controller determines that the real-time blood oxygen saturation difference is greater than the first standard blood oxygen saturation difference, the controller determines the real-time blood oxygen saturation difference according to the second standard blood oxygen saturation difference. If the real-time blood oxygen saturation difference is less than or equal to the second standard blood oxygen saturation difference, the real-time blood oxygen saturation will be judged according to the second standard blood oxygen saturation to determine whether to control the air supply valve to adjust the initial oxygen supply flow rate; If the real-time blood oxygen saturation difference is greater than the second standard blood oxygen saturation difference, an early warning will be issued.

4. The atomizing breathing drug delivery device according to claim 3, characterized in that: The controller determines the real-time blood oxygen saturation difference is less than or equal to the second standard blood oxygen saturation difference, and determines the real-time blood oxygen saturation according to the second standard blood oxygen saturation. If the real-time blood oxygen saturation is less than or equal to the second standard blood oxygen saturation, the controller will control the air supply valve to adjust the initial oxygen supply flow rate; If the real-time blood oxygen saturation is greater than the second standard blood oxygen saturation, the real-time cough number will be judged according to the standard cough number to determine the humidification state of the supplied medicine.

5. The atomizing breathing drug delivery device according to claim 4, characterized in that: When the controller determines that the real-time blood oxygen saturation is greater than the second standard blood oxygen saturation, the controller obtains the real-time coughing number detected by the respiratory detection instrument, and determines the real-time coughing number according to the first standard coughing number and the second standard coughing number. If the real-time coughing number is less than the first standard coughing number, it is determined that the humidification state of the supplied medicine is normal; If the real-time cough number is between the first standard cough number and the second standard cough number, the duration of each single cough is determined according to the standard single cough duration to adjust the humidification state of the supplied medicine; If the real-time coughing number is greater than the second standard coughing number, the real-time respiratory frequency difference is judged according to the standard respiratory frequency difference to determine whether to stop atomization.

6. The atomizing breathing drug delivery device according to claim 5, characterized in that: When the controller determines that the real-time cough frequency is between the first standard cough frequency and the second standard cough frequency, the controller obtains the duration of each single cough detected by the respiratory detection instrument, and determines the duration of each single cough according to the standard single cough duration. If there is a single cough duration that is greater than or equal to the standard single cough duration, the real-time cough frequency is determined according to the standard cough frequency to determine the method of adjusting the humidification state of the supplied medicine; If the duration of a single cough is less than the standard duration of a single cough, the initial pumping power of the infusion pump is adjusted according to the real-time number of coughs to a first corrected pumping power; Wherein, Pc1'=Pc×[1+(Ns-Nb1) / Ns], Pc1' represents the adjusted first corrected pumping power, Pc represents the initial pumping power, Nb1 represents the first standard cough number, and Ns represents the real-time cough number.

7. The atomizing breathing drug delivery device according to claim 6, characterized in that: When the controller determines that the duration of a single cough is greater than or equal to the standard duration of a single cough, the controller calculates the real-time cough frequency according to the detection data of the respiratory detection instrument, and determines the real-time cough frequency according to the standard cough frequency. If the real-time cough frequency is less than or equal to the standard cough frequency, adjusting the initial pumping power of the infusion pump according to the real-time cough frequency to a second corrected pumping power; If the real-time cough frequency is greater than the standard cough frequency, adjusting the real-time humidification temperature of the liquid storage tank according to the real-time cough frequency to a first corrected humidification temperature; Among them, Pc2'=Pc×[1+(Mb-Ms) / Ms], Ts1'=Ts×[1+(Ms-Mb) / Ms], Ts1' represents the adjusted second corrected humidification temperature, Ts represents the real-time humidification temperature, Pc2' represents the adjusted second corrected pumping power, Pc represents the initial pumping power, Mb represents the standard cough frequency, and Ms represents the real-time cough number.

8. The atomizing breathing drug delivery device according to claim 7, characterized in that: The controller calculates the real-time cough frequency according to the detection data of the breathing detection instrument, and when it is determined that the duration of a single cough is greater than or equal to the standard duration of a single cough, marks the corresponding cough behavior as a differential cough, and obtains the number of differential coughs within each preset monitoring time detected by the breathing detection instrument, and divides the number of differential coughs within each preset monitoring time by the preset monitoring time to obtain the corresponding real-time cough frequency.

9. The atomizing breathing drug delivery device according to claim 5, characterized in that: When the controller determines that the real-time coughing number is greater than the second standard coughing number, the controller calculates the real-time respiratory frequency difference according to the standard respiratory frequency and the real-time respiratory frequency based on the real-time respiratory frequency detected by the respiratory detection instrument, and determines the real-time respiratory frequency difference according to the standard respiratory frequency difference. If the real-time respiratory frequency difference is less than or equal to the standard respiratory frequency difference, adjusting the real-time humidification temperature of the liquid storage tank according to the real-time coughing number to a second corrected humidification temperature; If the real-time respiratory rate difference is greater than the standard respiratory rate difference, atomization is stopped and an early warning prompt is issued; Wherein, Ts2'=Ts×[1+(Ns-Nb2) / Ns], Ts2' represents the adjusted second corrected humidification temperature, Ts represents the real-time humidification temperature, Nb2 represents the second standard cough number, and Ns represents the real-time cough number.

10. The atomizing breathing drug delivery device according to claim 4, characterized in that: The controller can adjust the initial oxygen supply flow rate according to the real-time blood oxygen saturation detected by the breathing detection instrument. When the controller determines that the real-time blood oxygen saturation is less than or equal to the second standard blood oxygen saturation, the controller controls the air supply valve to adjust the initial oxygen supply flow rate to the corrected oxygen supply flow rate; Among them, Qc'=Qc×[1+(Fb2-Fs) / Fs], Qc' represents the adjusted corrected oxygen supply flow rate, Qc represents the initial oxygen supply flow rate, Fb2 represents the second standard blood oxygen saturation, and Fs represents the real-time blood oxygen saturation.

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