A whitening and moisturizing cream and its preparation method

Abstract

The present invention discloses a whitening and moisturizing cream and a preparation method thereof. The cream comprises: Phase A: allantoin 0.5 - 2.0%, glycerol 2 - 6%, 1,4 - butanediol 2.5 - 7%, sodium alginate 0.5 - 2%, vitamin C 0.2 - 1%, carbomer 0.1 - 0.3%, and an appropriate amount of water; Phase B: squalene 1 - 7%, limnanthes alba seed oil 1 - 15%, polyglyceryl - 3 diisostearate 1 - 6.5%, cetearyl glucoside 1 - 4.5%, sodium stearoyl lactylate 0.5 - 3.5%; Phase C: lophatherum gracile leaf / stem extract 0.01 - 1%, impatiens balsamina flower / leaf / stem extract 0.01 - 1%, luffa leaf extract 0.01 - 0.5%, silk extract 0.1 - 1.5%; Phase D: a whitening composition 0.5 - 1.5%; Phase E: phenoxyethanol 0.01 - 0.3%. The cream prepared by the present invention has excellent moisturizing and whitening effects, and the product is mild, safe and has good stability.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and specifically relates to a whitening and moisturizing cream and a preparation method thereof. Background Art

[0002] Having fair, bright and translucent skin has always been the goal pursued by many people. At the same time, it is crucial to do a good job in both moisturizing and whitening. Moisturizing can make the skin firmer. However, without whitening, the skin color will appear dull. If only whitening is done without moisturizing, the skin does appear white, but such skin is not healthy and is prone to various skin problems. Moreover, without sufficient moisture in the skin, the whitening effect will also be reduced.

[0003] Currently, the moisturizing and whitening effects of most creams in the prior art are developed separately. Patent CN115671013B discloses a whitening cream and a preparation method thereof. This cream mainly achieves rapid whitening through the combined action of core ingredients such as Porphyridium cruentum extract, glycyrrhetinic acid, and Avena strigosa seed extract. This patent only focuses on the whitening effect. Patent CN115068371B discloses a moisturizing cream with a repair effect and a preparation method thereof. Calculated by weight percentage, it includes the following components: egg yolk oil 6 - 9%, dextran 0.02 - 0.04%, fucoidan 3 - 5%, grape seed oil 0.05 - 0.08%, catechin 0.2 - 0.4%, sodium polyglutamate 0.3 - 0.6%. Based on the repair effect of the superimposed effects of egg yolk oil and dextran, this moisturizing cream can also have an extremely strong moisturizing effect. This patent focuses on the repair and moisturizing effects.

[0004] Therefore, it is very necessary to develop a cream that simultaneously takes into account powerful moisturizing and whitening effects to meet women's pursuit of "fair, bright and translucent" skin. Summary of the Invention

[0005] The purpose of the present invention is to provide a whitening and moisturizing cream and a preparation method thereof, which cream simultaneously has powerful water replenishing and moisturizing and whitening effects.

[0006] To this end, the present invention adopts the following technical solutions:

[0007] The invention provides a whitening and moisturizing facial cream, which comprises the following components in percentage by weight: phase A: 0.5-2.0% of allantoin, 2-6% of glycerol, 2.5-7% of 1,4-butylene glycol, 0.5-2% of sodium alginate, 0.2-1% of vitamin C, 0.1-0.3% of carbomer, and an appropriate amount of water; phase B: 1-7% of squalene, 1-15% of meadowfoam seed oil, 1-6.5% of polyglycerol-3 diisostearate, 1-4.5% of cetearyl glucoside, and 0.5-3.5% of sodium stearoyl lactylate; phase C: 0.01-1% of LOPHATHERUM GRACILE leaf / stem extract, 0.01-1% of Impatiens balsamina BALSAMINA) flower / leaf / stem extract 0.01-1%, loofah leaf extract 0.01-0.5%, silk extract 0.1-1.5%, D phase: whitening composition 0.5-1.5%, E phase: phenoxyethanol 0.01-0.3%;

[0008] The whitening composition comprises, by weight, 1-7 parts of hydrangea serrata leaf extract, 1-5 parts of hydrangea crassifolia fruit extract, 1-5 parts of honeysuckle extract and 0.5-3 parts of raspberry ketone glucoside.

[0009] In the above technical scheme, Lophatherum GRACILE was first recorded in Compendium of Materia Medica. It is sweet, light and cold in taste, and it enters the heart, stomach and small intestine meridians. It can clear away heat, detoxify, promote diuresis and relieve restlessness. The active ingredients of Lophatherum GRACILE extract include flavonoids, phenolic acids, anthraquinones, lactones, polysaccharides, amino acids, trace elements, etc. It has excellent anti-free radical, anti-oxidation, anti-aging, anti-fatigue, blood lipid lowering, prevention of cardiovascular and cerebrovascular diseases, protection of the liver, dilation of capillaries, dredging of microcirculation, activation of the brain, promotion of memory, improvement of sleep, anti-cancer, beautification of the skin and other effects. Lophatherum GRACILE leaf / stem extract can help improve skin hydration, reduce the appearance of fine lines and wrinkles, and protect the skin from UV damage.

[0010] In the above technical solution, the whole plant of Impatiens balsamina is divided into six parts, namely roots, stems, leaves, flowers, fruits and seeds, and all six parts can be used as medicine. The flower / leaf / stem extract of Impatiens balsamina has an inhibitory effect on hyaluronidase, can effectively inhibit the decomposition of hyaluronic acid, and is beneficial to skin moisturizing.

[0011] In the above technical solution, the sponge gourd leaf extract contains a large amount of natural moisturizing factors, and the non-sticky moisturizing ingredients can effectively soothe tight and dry skin, keep the facial skin moisturized, elastic and shiny.

[0012] In the above technical solution, silk is a natural protein fiber with a protein content of over 96%. Its structure is similar to that of skin and hair. Silk extracts mainly include fibroin and sericin. In "Compendium of Materia Medica", there are records that fibroin can remove skin dark spots and treat suppurative dermatitis. The main component of fibroin is amino acid, which has a good moisturizing effect on the skin cutin layer, can also absorb ultraviolet rays, and has the function of resisting sunlight radiation. Sericin is a soluble natural pure silk protein that can be absorbed by the human skin. Its main function is to moisturize, keep a certain amount of moisture in the skin cutin layer, and also has the function of inhibiting the activity of tyrosinase.

[0013] In the above technical solution, the extract of Hydrangea serrata Thunb. leaves has a promoting effect on the production of collagen, can eliminate free radicals at the same time, and has the effect of anti-aging and anti-wrinkle; it has a promoting effect on the activity of luciferase and has an anti-inflammatory effect; it can also promote autophagy of fibroblasts in the skin.

[0014] In the above technical solution, the extract of Mitrasacme perfoliata Labill. has whitening active ingredients, has a relatively strong inhibitory effect on tyrosinase, can treat pigmentation and age spots; has the effect of eliminating free radicals, can be used as an antioxidant, and can delay skin aging.

[0015] In the above technical solution, the extract of Lonicera dasystyla Rehd. mainly includes chlorogenic acid, caffeotannic acid, etc., and has the effects of anti-inflammatory, antioxidant, anti-allergic, and pigment inhibition.

[0016] In the above technical solution, raspberry ketone glucoside has strong antioxidant properties, can neutralize free radicals, reduce oxidative damage to the skin caused by environmental factors and ultraviolet radiation; can stimulate the synthesis of collagen. Collagen is an important component in the skin, which can improve the elasticity of the skin, reduce the appearance of fine lines and wrinkles; has the function of inhibiting the activity of tyrosinase, can reduce the formation of melanin, fade age spots, freckles and other skin color uneven problems, and brighten the skin tone; has soothing and anti-swelling effects, can reduce skin inflammatory reactions and sensitive symptoms, relieve swelling and stinging, and improve skin sensitivity problems.

[0017] As a preferred technical solution, the mass ratio of squalene to Limnanthes alba seed oil is 1:(3 - 10).

[0018] More preferably, the mass ratio of squalene to Limnanthes alba seed oil is 1:(3 - 6).

[0019] In the above technical solution, squalene and Limnanthes alba seed oil are emollients. Defining the proportion of emollients is beneficial to promoting the mixing of raw materials with different properties, especially the mixing of moisturizing components and whitening compositions into the system, and improving the skin-friendly absorption effect.

[0020] As a preferred technical solution, the weight ratio of the LOPHATHERUM GRACILE leaf / stem extract, IMPATIENS BALSAMINA flower / leaf / stem extract, loofah leaf extract and silk extract is (0.3-1):(0.3-1):(0.5-2):(1-5).

[0021] Further, the preparation method of the silk extract includes: after washing the cocoon, soaking it in water for a period of time, adding alcohol for high-pressure extraction, filtering, and freeze-drying the filtrate to obtain the silk extract.

[0022] Further, the weight ratio of the water to the cocoon is (5-20):1, and the soaking time is 3-5h.

[0023] Further, the volume ratio of the alcohol to the water is 1:(1-5).

[0024] Further, the pressure for extraction is 0.3-0.7MPa, the extraction temperature is 80-100°C, and the extraction time is 2-3h.

[0025] Preferably, the alcohol is ethanol or isopropanol.

[0026] The present invention also provides a preparation method of a whitening and moisturizing cream, including the following steps:

[0027] 1) Add the raw materials of phase A to the emulsifying pot, heat to 80-85°C, stir until uniform, keep warm for 15-30min, and dissolve all components completely for standby;

[0028] 2) Add the raw materials of phase B to the oil phase pot, heat to 70-83°C, stir until uniform, and dissolve all components for standby;

[0029] 3) Pump the well-dissolved raw materials of group B into the emulsifying pot with a vacuum pump, stir and homogenize at a speed of 1400-1600rpm / min, and stir and cool down to 40°C to 45°C;

[0030] 4) Add the components of phase C, phase D and phase E in sequence, keep warm and stir for 10-15min, and stir until the temperature drops to room temperature to obtain the whitening and moisturizing cream.

[0031] Compared with the prior art, the beneficial effects of the present invention are:

[0032] The technical solution of the present invention uses the extracts of Lophatherum gracile leaves / stems, Impatiens balsamina flowers / leaves / stems, loofah leaf extracts and silk extracts prepared by the method provided by the present invention. Especially when the ratio is controlled within the range of (0.3-1):(0.3-1):(0.5-2):(1-5), it can coordinately produce excellent moisturizing ability.

[0033] The technical solution of the present invention uses the combination of Hydrangea serrata leaf extracts, Mitrasacme perpusilla extracts, Lonicera dasystyla Rehd. extracts and glucosyl rutin. It can not only inhibit the activity of tyrosinase, but also scavenge free radicals, resist the damage of ultraviolet radiation to the skin, coordinately enhance the cell activity of the skin, reduce pigmentation and brighten the skin tone. The Hydrangea serrata leaf extracts of the present invention can wrap melanosomes through the autophagy pathway of cells and decompose them by the hydrolases of lysosomes; the Mitrasacme perpusilla extracts, Lonicera dasystyla Rehd. extracts and glucosyl rutin have relatively strong inhibitory effects on tyrosinase. The four components coordinately enhance the inhibition of tyrosinase activity and make the skin fair and bright.

[0034] In the present invention, controlling the ratio of squalene to Limnanthes alba seed oil at 1:(3-10) can improve the absorption efficiency of active components and is beneficial to obtaining better moisturizing and whitening effects.

[0035] The components of the whitening and moisturizing cream of the present invention are scientifically formulated, which can improve the stability of the emulsification system. The active ingredients are better emulsified, dispersed and coated, and are more easily absorbed by the skin. The active moisturizing factors enter the stratum corneum to strengthen the barrier function, lock water and moisturize persistently, enhance cell vitality. The various substances in the whitening composition are compounded with each other to inhibit the production of tyrosinase in melanocytes and promote the dull skin to become fair, bright and translucent. Specific Embodiments

[0036] The following are specific examples to further describe the specific implementation manners of the technical solutions of this specification. These examples are for the detailed description of the technical solutions and not for limiting the technical solutions. Based on the examples in this specification, all other examples obtained by those of ordinary skill in the art without creative efforts fall within the scope of protection of this specification. It should be noted that unless otherwise specified, all components used in the present invention are existing materials in the art, which can be obtained through commercial channels or prepared by existing methods.

[0037] Preparation Example 1

[0038] A preparation method of silk extract. After cleaning the silkworm cocoons, soak them in 15 times the weight of water for 5 h, then add 1 / 3 times the volume of ethanol and perform high-pressure extraction for 3 h at a pressure of 0.3 - 0.7 MPa and a temperature of 80 - 100 °C. Filter, and after freeze-drying the filtrate, silk extract is obtained.

[0039] The prepared silk extract is used as a raw material in the following examples and comparative examples.

[0040] Examples 1 - 4

[0041] A whitening and moisturizing cream is prepared from raw materials of phase A (aqueous phase), phase B (oil phase), phase C, phase D, and phase E. The specific formula is shown in Table 1 below.

[0042] Table 1 Formula table of the whitening and moisturizing cream in Examples 1 - 4

[0043]

[0044]

[0045] The whitening and moisturizing creams in Examples 1 - 4 are prepared according to the following method:

[0046] 1) Add the raw materials of phase A to the aqueous phase emulsifying pot, heat to 85 °C, set the stirring speed to 820 revolutions per minute until completely dissolved without particles, and set aside;

[0047] 2) Add the raw materials of phase B to the oil phase pot, heat up to 80 °C, set the stirring speed to 800 revolutions per minute until completely dissolved without particles, and set aside;

[0048] 3) Pump the well-heated and dissolved raw materials of group B into the emulsifying pot with a vacuum pump, and stir and homogenize at a speed of 1400 - 1600 rpm / min for 10 min;

[0049] 4) Stir and cool down to 45 °C, add the raw materials of phase C, and stir evenly;

[0050] 5) Stir and cool down to 42 °C, add the raw materials of phase D, and stir evenly;

[0051] 6) Stir and cool down to 40 °C, add the raw materials of phase F, and stir evenly;

[0052] 7) After passing the inspection, discharge and fill, and then it is obtained.

[0053] Comparative Example 1

[0054] The difference between Comparative Example 1 and Example 3 is that the silk extract in phase C is removed, and the rest is the same as in Example 3. The preparation method is the same.

[0055] Comparative Example 2

[0056] The difference between Comparative Example 2 and Example 3 lies in that the extracts of LOPHATHERUM GRACILE leaves / stems, IMPATIENS BALSAMINA flowers / leaves / stems, and loofah leaves in Phase C are removed, and the rest is the same as in Example 3. The preparation method is the same.

[0057] Comparative Example 3

[0058] The difference between Comparative Example 3 and Example 3 lies in that the addition amount of silk extract in Phase C is 0.02%, and the rest is the same as in Example 3. The preparation method is the same.

[0059] Comparative Example 4

[0060] The difference between Comparative Example 4 and Example 3 lies in that the coarse-toothed hydrangea leaf extract in Phase D is removed, and the rest is the same as in Example 3. The preparation method is the same.

[0061] Comparative Example 5

[0062] The difference between Comparative Example 5 and Example 3 lies in that the rough cap fruit extract in Phase D is removed, and the rest is the same as in Example 3. The preparation method is the same.

[0063] Comparative Example 6

[0064] The difference between Comparative Example 6 and Example 3 lies in that the Lonicera dasystyla Rehd. extract in Phase D is removed, and the rest is the same as in Example 3. The preparation method is the same.

[0065] Comparative Example 7

[0066] The difference between Comparative Example 7 and Example 3 lies in that the raspberry ketone glucoside in Phase D is removed, and the rest is the same as in Example 3. The preparation method is the same.

[0067] Comparative Example 8

[0068] The difference between Comparative Example 8 and Example 3 lies in that the rough cap fruit extract and the Lonicera dasystyla Rehd. extract in Phase D are removed, and the rest is the same as in Example 3. The preparation method is the same.

[0069] Comparative Example 9

[0070] The difference between Comparative Example 9 and Example 3 lies in that the coarse-toothed hydrangea leaf extract and the raspberry ketone glucoside in Phase D are removed, and the rest is the same as in Example 3. The preparation method is the same.

[0071] Comparative Example 10

[0072] The difference between Comparative Example 10 and Example 3 is as follows: the mass ratio of squalene to Limnanthes alba seed oil in Phase B is 1:0.5, and the rest is the same as in Example 3. The preparation method is the same.

[0073] Comparative Example 11

[0074] The difference between Comparative Example 11 and Example 3 is as follows: the mulberry silk extract is a commercially available product, and the rest is the same as in Example 3. The preparation method is the same.

[0075] Comparative Example 12

[0076] The difference between Comparative Example 12 and Example 3 is as follows: the content of the whitening composition in Phase D is 0.1%, the content of polyglyceryl-3 diisostearate in Phase B is 0.3%, and the content of sodium alginate in Phase A is 0.3%. The rest is the same as in Example 3. The preparation method is the same.

[0077] Test Example 1: Safety evaluation

[0078] Refer to the "Human Skin Patch Test" in the "Technical Specifications for Cosmetics Safety" (2015 Edition) to

[0079] Example 1

[0080] -4 and the safety of the whitening and moisturizing creams of Comparative Examples 1-12 were evaluated.

[0081] Test results: After 24 hours, the skin reactions of each group of subjects were observed through the repeated open application test of the whitening and moisturizing creams of the examples and comparative examples. The results showed that 0 cases had skin adverse reactions (negative reactions), indicating that the whitening and moisturizing cream of the present invention is safe, mild and non-irritating.

[0082] Test Example 2: Moisturizing effect test

[0083] Test subjects: 150 healthy female volunteers aged 25-45 without a history of allergies were selected and divided into 15 groups, with 10 subjects in each group. The whitening and moisturizing creams of the examples and comparative examples were tested. All subjects had signed an informed consent form.

[0084] Test method: The moisture content was measured by the CORNEOMETER-capacitance method. During the test, the inner sides of the left and right forearms of the subjects were used as the test sites for immediate measurement, and the water content of the stratum corneum of the skin was compared before using the product and 1, 4, and 8 hours after using the product. The test product was applied once at a dosage of 2.0 ± 0.1 mg / cm 2 using a latex finger cot to evenly apply the sample to an area of (2 cm 2 × 2 cm 2)Within the test area. The experimental instrument is: Corneometer CM825, produced by CK Company, Germany. The higher the skin moisture content, the more obvious the moisturizing effect. The test results are shown in Table 2.

[0085] Table 2 Test Results of Skin Water Content

[0086]

[0087]

[0088] As can be seen from Table 2, after the subjects used the whitening and moisturizing creams of Examples 1-4 and Comparative Examples 1-11 for 1 h, 4 h, and 8 h respectively, the skin water content of the subjects increased. The water content increase rates of Examples 1-4 were significantly higher than those of Comparative Examples 1-11. Among them, Example 3 was the highest, being 55.16%, 47.85%, and 39.40% respectively.

[0089] Compared with Example 3, the cream of Comparative Example 1 does not contain silk extract. The water content increase rates after using it for 1 h, 4 h, and 8 h were 18.46%, 12.47%, and 8.46% respectively, which were significantly lower than those of Example 3.

[0090] Compared with Example 3, the cream of Comparative Example 2 does not contain LOPHATHERUM GRACILE leaf / stem extract, IMPATIENS BALSAMINA flower / leaf / stem extract, and loofah leaf extract. The water content increase rates after using it for 1 h, 4 h, and 8 h were 17.73%, 12.12%, and 8.38% respectively, which were significantly lower than those of Example 3.

[0091] Compared with Example 3, the proportion of silk extract in Comparative Example 3 was [proportion value]. The water content increase rates after using it for 1 h, 4 h, and 8 h were 16.65%, 11.95%, and 7.37% respectively, which were significantly lower than those of Example 3.

[0092] Compared with Example 3, Comparative Examples 4-7 do not contain Hydrangea serrata leaf extract, Physalis angulata extract, Lonicera dasystyla extract, and glucosyl rutin respectively. The water content after using it for 1 h, 4 h, and 8 h was also significantly lower than that of Example 3, but higher than that of Comparative Examples 1-3.

[0093] Compared with Example 3, Comparative Examples 8-9 each lacked 2 components, namely Physalis angulata extract and Lonicera dasystyla extract, and Hydrangea serrata leaf extract and glucosyl rutin respectively. The water content after using it for 1 h, 4 h, and 8 h was also significantly lower than that of Example 3, and was close to that of Comparative Examples 1-3.

[0094] Compared with Example 3, in Comparative Example 10, the mass ratio of squalene to Limnanthes Alba Benth. seed oil is 1:0.5, and the two are not within the preferred ratio range given in the present invention. The water content after using for 1 h, 4 h and 8 h is also significantly lower than that in Example 3, but higher than that in Comparative Examples 1-9.

[0095] Compared with Example 3, in Comparative Example 11, the silk extract is a commercially available product and is not prepared by the extraction method of the present invention. The water content after using for 1 h, 4 h and 8 h is lower than that in Example 3.

[0096] From the test data of the examples and comparative examples, it can be seen that the extracts of Lophatherum gracile leaves / stems, Impatiens balsamina flowers / leaves / stems, Luffa cylindrica leaves and silk extracts of the present invention can coordinately improve the moisturizing effect, and within a suitable ratio range, a better moisturizing effect can be obtained. The silk extract prepared by the extraction method of the present invention can obtain a better moisturizing effect. The whitening composition of the present invention has a certain level of moisturizing effect. The lack of one or two of them will reduce the moisturizing effect. The mass ratio of the emollient squalene to Limnanthes Alba Benth. seed oil is controlled within the range of 1:(3-10), and the moisturizing effect is better, otherwise the moisturizing effect will be reduced. Therefore, the components in the cream of the present invention are a scientifically formulated formula. Exceeding the ratio range of the present invention or lacking the C phase or D component will reduce the moisturizing efficacy.

[0097] Test Example 3: Tyrosinase activity inhibition test

[0098] According to "Cosmetics - Test Method for Tyrosinase Activity Inhibition (T / SHRH015-2018)", the cream samples were diluted to a concentration of 7%, and the inhibition rates (%) of tyrosinase of the whitening and moisturizing cream samples prepared in the above Examples 1-4 and Comparative Examples 1-12 were detected respectively. The higher the inhibition rate, the better the whitening effect of the whitening and moisturizing cream. The test results are shown in Table 3:

[0099] Table 3 Inhibition of tyrosinase activity by whitening and moisturizing cream

[0100]

[0101]

[0102] As can be seen from Table 3, the whitening and moisturizing creams of Examples 1-4 have a stronger inhibitory effect on tyrosinase activity than those of Comparative Examples 1-12. In particular, Example 3 has the best effect, with a significant inhibitory effect on tyrosinase activity, indicating its good whitening effect. In Comparative Examples 1-10, one or two components in Phase C or Phase D are missing, or the ratio of the components is not within the range given in the present invention, and the inhibitory effect on tyrosinase activity will be weakened. In Comparative Example 11, the silk extract prepared by the preparation method of the present invention is not used, and the inhibitory effect on tyrosinase activity is worse than that of Example 3. In Comparative Example 12, the contents of the whitening composition, emulsifier, etc. are not within the formula range, and the inhibitory effect on tyrosinase activity is poor. It shows that the whitening and moisturizing cream of the formula of the present invention has a good inhibitory effect on tyrosinase activity. Beyond the formula range, the inhibitory effect on tyrosinase activity will be weakened.

[0103] Test Example 4: DPPH-Radical Scavenging Experiment

[0104] According to "Cosmetics - Radical (DPPH) Scavenging Experiment Method (T / SHRH006-2018)", the cream samples were diluted to a concentration of 7%, and the DPPH radical scavenging rates (%) of the whitening and moisturizing cream samples prepared in Example 3 and Comparative Examples 1, 4-9 were detected respectively. The higher the scavenging rate, the better the antioxidant and anti-aging effects of the whitening and freckle-removing cream. The test results are shown in Table 4:

[0105] Table 4 DPPH Radical Scavenging Rates of Whitening and Moisturizing Creams

[0106]

[0107] As can be seen from Table 4, the whitening and moisturizing cream of Example 3 has excellent free radical scavenging ability, significantly superior to Comparative Example 1 and Comparative Examples 4-9.

[0108] Test Example 5: Stability Evaluation

[0109] 1) Cold resistance stability: The whitening and moisturizing creams described in Examples 1-4 and Comparative Examples 1, 3, 10, and 12 were placed in a constant temperature incubator at -20°C for 48 hours, and whether there were phenomena such as stratification and hardness change was observed. If the moisturizing and repairing cream had no change, it represented a stable system; the experimental results are shown in Table 5.

[0110] 2) Heat resistance stability: The whitening and moisturizing creams described in Examples 1-4 and Comparative Examples 1, 3, 10, and 12 were placed in an electrothermal constant temperature incubator at (40±1)°C for 48h, and whether there were phenomena such as stratification and color change was observed. If the moisturizing and repairing cream had no change, it represented a stable system; the experimental results are shown in Table 5.

[0111] 3) Centrifugal stability: The whitening and moisturizing creams described in Examples 1-4 and Comparative Examples 1, 3, 10, and 12 were centrifuged at 2800 r / min for 20 min, and whether there were phenomena such as separation and stratification was observed. If there was no change in the moisturizing and repairing cream, it indicated that the system was stable; the experimental results are shown in Table 5.

[0112] Table 5 Test results of stability performance

[0113] Cold resistance stability Heat resistance stability Centrifugal stability Example 1 Stable Stable Stable Example 2 Stable Stable Stable Example 3 Stable Stable Stable Example 4 Stable Stable Stable Comparative Example 1 Stable Stable Stable Comparative Example 3 Stable Stable Stable Comparative Example 10 Stable Slight delamination Stable Comparative Example 12 Slight delamination Slight delamination Slight delamination

[0114] As can be seen from Table 5, the whitening and moisturizing creams of Examples 1-4 have excellent cold resistance, heat resistance, and centrifugal stability, and the product stability is better.

[0115] In summary, the whitening and moisturizing cream provided by the present invention has a good effect of inhibiting tyrosinase activity, the ability to scavenge DPPH free radicals, an excellent moisturizing effect, and the product is mild, safe, non-irritating, and has good stability.

[0116] Although the embodiments of the present specification have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the present specification. The scope of the present specification is defined by the appended claims and their equivalents.

Claims

1. A whitening and moisturizing facial cream, characterized in that: The invention comprises the following components in percentage by weight: phase A: 0.5-2.0% allantoin, 2-6% glycerol, 2.5-7% 1,4-butylene glycol, 0.5-2% sodium alginate, 0.2-1% vitamin C, 0.1-0.3% carbomer, and an appropriate amount of water; phase B: 1-7% squalene, 1-15% white meadowfoam seed oil, 1-6.5% polyglyceryl-3 diisostearate, 1-4.5% cetearyl glucoside, 0.5-3.5% sodium stearoyl lactylate; phase C: 0.01-1% LOPHATHERUMGRACILE leaf / stem extract, 0.01-1% impatiens balsamina BALSAMINA) flower / leaf / stem extract 0.01-1%, loofah leaf extract 0.01-0.5%, silk extract 0.1-1.5%, D phase: whitening composition 0.5-1.5%, E phase: preservative 0.01-0.3%; F phase: thickener 0.1-0.3%; by weight, the whitening composition comprises 1-7 parts of hydrangea coarse tooth leaf extract, 1-5 parts of rough cap fruit extract, 1-5 parts of hairy style honeysuckle extract and 0.5-3 parts of raspberry ketone glucoside; the horn The mass ratio of squalene to white meadowfoam seed oil is 1:(3-10); the preparation method of the silk extract comprises: washing the silk cocoons, soaking them in water for a period of time, adding alcohol for high-pressure extraction, filtering, and freeze-drying the filtrate to obtain the silk extract; the weight ratio of water to silk cocoons is (5-20):1, and the soaking time is 3-5h; the volume ratio of alcohol to water is 1:(1-5); the extraction pressure is 0.3-0.7MPa, the extraction temperature is 80-100°C, and the extraction time is 2-3h.

2. The whitening and moisturizing facial cream according to claim 1, characterized in that: The mass ratio of squalene to meadowfoam seed oil is 1:(3-6).

3. The whitening and moisturizing facial cream according to claim 1, characterized in that: The weight ratio of the Lophatherum GRACILE leaf / stem extract, Impatiens BALSAMINA flower / leaf / stem extract, Luffa cycad leaf extract and silk extract is (0.3-1):(0.3-1):(0.5-2):(1-5).

4. The whitening and moisturizing facial cream according to claim 1, characterized in that: The alcohol is ethanol or isopropanol.

5. The method for preparing the whitening and moisturizing facial cream according to any one of claims 1 to 4, characterized in that: The following steps are involved: 1) Add the raw materials of phase A into an emulsifying pot, heat to 80-85°C, stir until uniform, keep warm for 15-30 minutes, and all components are fully dissolved for use; 2) Add the raw materials of phase B into an oil phase pot, heat to 70-83°C, stir until uniform, and all components are dissolved for use; 3) Use a vacuum pump to pump the heated and dissolved raw materials of group B into the emulsifying pot, stir and homogenize at a speed of 1400-1600r / min, and stir to cool down to 40°C to 45°C; 4) Add the components of phase C, phase D and phase E in sequence, keep warm and stir for 10-15 minutes, and stir to cool down to room temperature to obtain a whitening and moisturizing facial cream.

Images