A compound fritillaria and loquat capsule and its application

Abstract

This invention relates to the field of traditional Chinese medicine technology, and provides a compound fritillaria and loquat capsule and its application. The compound fritillaria and loquat capsule is prepared from the following traditional Chinese medicines: loquat leaf 10-12g, cinnamon twig 9-10g, codonopsis root 10-12g, platycodon root 5-6g, fritillaria bulb 5-6g, pinellia tuber 5-6g, tangerine peel 5-6g, dried ginger 2-3g, and menthol 0.5-1g. The compound fritillaria and loquat capsule of this invention improves the circulation of qi and blood in the lungs and the whole body by warming and dispelling cold and dampness, clearing lung qi, and enhancing spleen and stomach function, thereby relieving cold-type cough and its accompanying phlegm symptoms, thus achieving the effect of relieving cough and resolving phlegm. It is particularly suitable for patients with cough caused by cold stimulation. When used in combination, the traditional Chinese medicines of this invention can significantly improve the body weight of mice with cold cough, significantly prolong the cough latency period of mice with cold cough, and reduce the frequency of coughing in mice, showing a significant antitussive effect. At the same time, it can significantly increase the amount of phenol red excreted in the trachea of ​​mice with cold cough, showing a significant expectorant effect.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine preparations, specifically relating to a compound fritillaria and loquat capsule and its application. Background Technology

[0002] In the field of traditional Chinese medicine treatment of cough, Compound Fritillaria and Loquat Capsules have attracted much attention due to their unique effects of clearing the lungs, resolving phlegm, relieving cough, and alleviating asthma. With Fritillaria cirrhosa, Platycodon grandiflorus, Eriobotrya japonica leaf, and menthol as its core ingredients, this combination effectively relieves cough symptoms caused by colds, throat inflammation, or other respiratory infections through multiple mechanisms of action, including moisturizing the lungs, relieving cough, and clearing phlegm and soothing the throat. Both Fritillaria cirrhosa and Eriobotrya japonica leaf have the effects of clearing heat, moisturizing the lungs, resolving phlegm, and relieving cough; they are commonly used herbs in traditional Chinese medicine prescriptions, especially suitable for relieving symptoms such as dry cough, little phlegm, and thick phlegm.

[0003] However, the application of Compound Fritillaria and Loquat Capsules in patients with a cold constitution may be somewhat limited. People with a cold constitution typically exhibit symptoms such as low body temperature, cold hands and feet, and sensitivity to cold. While Compound Fritillaria and Loquat Capsules are warming in nature and may improve symptoms of cold-type coughs, long-term use by patients with a cold constitution may lead to an imbalance of cold and heat in the body, resulting in discomfort such as fever and dry mouth. Furthermore, prolonged use of warming cough suppressants may not effectively regulate the constitution of patients with a cold constitution, making it difficult to expel cold and dampness from the body, thus affecting the overall recovery outcome.

[0004] To overcome the aforementioned shortcomings, mild, neutral-natured herbs such as Codonopsis pilosula and Atractylodes macrocephala can be introduced into the formula of Compound Fritillaria cirrhosa and Loquat Capsules to help enhance the digestive function of the spleen and stomach, regulate cold constitution, and prevent the medicine from being too hot. Simultaneously, herbs with cooling properties, such as reed rhizome and bamboo leaves, can be appropriately added to regulate the overall temperature balance of the composition, making it more suitable for patients with cold constitutions while treating cold-type coughs. Adding Cinnamomum cassia to Compound Fritillaria cirrhosa and Loquat Capsules can further enhance its warming and dispersing effects, making it more suitable for coughs caused by cold constitutions. These improvements can effectively reduce the body's sensitivity to the medicine's properties while retaining its cough-relieving and phlegm-reducing effects, broadening its applicable population and improving the clinical application efficacy of the drug. Summary of the Invention

[0005] To address the aforementioned problems, the present invention first provides a compound fresh bamboo herbal composition for relieving cough and its application.

[0006] This invention provides a compound fritillaria and loquat capsule prepared from the following raw materials by weight: 10-12g loquat leaves, 9-10g cinnamon twigs, 10-12g codonopsis, 5-6g platycodon, 5-6g fritillaria, 5-6g pinellia, 5-6g tangerine peel, 2-3g dried ginger, and 0.5-1g menthol.

[0007] In some embodiments, the traditional Chinese medicine composition is prepared from the following raw materials by weight: 12g loquat leaf, 10g cinnamon twig, 12g codonopsis root, 5g platycodon root, 6g fritillaria bulb, 6g pinellia tuber, 5g dried tangerine peel, 2g dried ginger, and 0.5g menthol.

[0008] In some embodiments, the traditional Chinese medicine composition is prepared from the following raw materials by weight: 10g loquat leaf, 10g cinnamon twig, 10g codonopsis root, 6g platycodon root, 5g fritillaria bulb, 5g pinellia tuber, 6g dried tangerine peel, 2g dried ginger, and 1g menthol.

[0009] In some embodiments, the traditional Chinese medicine composition is prepared from the following raw materials by weight: 12g loquat leaf, 9g cinnamon twig, 12g codonopsis root, 6g platycodon root, 5g fritillaria bulb, 6g pinellia tuber, 6g dried tangerine peel, 3g dried ginger, and 1g menthol.

[0010] In some embodiments, the traditional Chinese medicine composition is prepared from the following raw materials by weight: 12g loquat leaf, 10g cinnamon twig, 10g codonopsis root, 5g platycodon root, 6g fritillaria bulb, 6g pinellia tuber, 6g dried tangerine peel, 2g dried ginger, and 0.5g menthol.

[0011] In some embodiments, the traditional Chinese medicine composition is prepared from the following raw materials by weight: 12g loquat leaf, 10g cinnamon twig, 12g codonopsis root, 5g platycodon root, 6g fritillaria bulb, 6g pinellia tuber, 6g dried tangerine peel, 2g dried ginger, and 0.5g menthol.

[0012] In addition, the present invention also provides the application of a traditional Chinese medicine preparation in the preparation of a drug for treating cough.

[0013] The compound fritillaria and loquat capsule of this invention is used to treat cold-induced irritative cough. Its formula includes loquat leaf, cinnamon twig, codonopsis, platycodon, fritillaria, pinellia, tangerine peel, dried ginger, and menthol. The combination of these ingredients, through their unique pharmacological effects, collectively exerts the effects of relieving cough, resolving phlegm, warming the middle jiao (digestive system), and dispelling cold. The mechanism of action of each ingredient in treating cold-induced cough is explained in detail below:

[0014] The principal drug is the main ingredient in the formula, directly targeting the cause of the disease.

[0015] Loquat leaves: They have the effects of clearing the lungs, relieving cough, and resolving phlegm. Loquat leaves can clear lung heat, regulate lung function, moisten the lungs, relieve asthma, and alleviate cough caused by cold stimulation.

[0016] Cinnamon twig: Warms the meridians and dispels cold, promotes the flow of qi through the meridians. Cinnamon twig can dispel cold and promote yang, and is especially suitable for lung qi stagnation caused by cold pathogens. Its warming effect helps relieve the pressure of cold on the lungs and restore the smooth flow of qi in the lungs.

[0017] Codonopsis pilosula: It tonifies the middle energizer, replenishes qi, nourishes the lungs, and moistens dryness. Codonopsis pilosula enhances spleen and stomach function, helps generate qi and blood, ensures sufficient lung qi, and strengthens the body's resistance. For coughs caused by a cold constitution, Codonopsis pilosula can regulate the constitution and improve lung function.

[0018] The assistant herbs assist the principal herbs, working together to enhance the therapeutic effect:

[0019] Platycodon grandiflorus: Clears the lungs, soothes the throat, and eliminates phlegm. It is effective in relieving cough and eliminating phlegm by clearing lung qi and helping to expel phlegm. Platycodon grandiflorus has a good effect on improving thick, sticky phlegm in cold-type coughs.

[0020] Fritillaria cirrhosa: Clears heat and resolves phlegm, moistens the lungs and relieves cough. Fritillaria cirrhosa can clear heat and resolve phlegm without damaging the body's vital energy. It helps relieve cough caused by cold stimulation and has a significant effect on moistening the lungs.

[0021] Pinellia ternata: It dries dampness, resolves phlegm, and relieves nausea and vomiting. Pinellia ternata excels at drying dampness and resolving phlegm, making it suitable for patients with cold-type coughs accompanied by phlegm and dampness. It can clear the airways and reduce the frequency and severity of coughs.

[0022] Dried tangerine peel: Regulates qi and resolves phlegm, strengthens the spleen and stomach. Dried tangerine peel can regulate qi and harmonize the middle jiao, resolve phlegm and stop coughing, helping to improve chest tightness and qi stagnation associated with cold-type coughs. The warming effect of dried tangerine peel is particularly suitable for cold-type coughs.

[0023] Adjuvant and guiding herbs assist principal and assistant herbs, enhancing overall efficacy and reducing drug side effects:

[0024] Dried ginger: warms the middle jiao (spleen and stomach), dispels cold, restores yang, and unblocks the meridians. Dried ginger can warm the middle jiao and dispel cold, and has a direct effect on warming the lungs and removing cold for coughs caused by cold constitution, effectively relieving airway discomfort caused by cold pathogens.

[0025] Menthol: It dispels wind and heat, and soothes the throat. Menthol has a cooling sensation that can relieve throat discomfort caused by cold stimulation. Although the overall effect is mainly warming and nourishing, the cooling effect of menthol moderately balances it, making the medicinal effect more gentle.

[0026] The traditional Chinese medicine composition described in this application achieves a holistic effect of warming the middle jiao and dispelling cold, clearing the lungs and resolving phlegm, and regulating qi through the combination of principal, assistant, and adjuvant herbs. Coughs caused by cold stimulation are often related to the invasion of cold pathogens and stagnation of qi. Compound Fritillaria and Loquat Capsules improve the circulation of qi and blood in the lungs and the whole body by warming and dispelling cold and dampness, clearing lung qi, and enhancing spleen and stomach function, thereby relieving cold-induced cough and its accompanying phlegm symptoms, and thus achieving the effect of stopping cough and resolving phlegm.

[0027] The principal herbs, loquat leaf, cinnamon twig, and codonopsis, work together to dispel cold and warm the lungs, helping the body expel cold pathogens. The assistant herbs, platycodon root, fritillaria bulb, pinellia tuber, and tangerine peel, further resolve phlegm and soothe the throat, ensuring clear airways and improving lung and spleen function. The adjuvant herbs, dried ginger and menthol, with their warming, dispersing, lung-clearing, and exterior-releasing effects, effectively promote the overall cough-relieving and phlegm-resolving effects.

[0028] Furthermore, the combination of the Chinese medicinal materials in the above-mentioned proportions of the present invention can significantly improve the body weight of mice with cold cough, significantly prolong the cough latency period of mice with cold cough, reduce the number of coughs in mice, and has a significant antitussive effect; at the same time, it can significantly increase the amount of phenol red excreted in the trachea of ​​mice with cold cough, and has a significant expectorant effect. Detailed Implementation

[0029] To make the technical problems, technical solutions and advantages of the present invention clearer, a detailed description will be given below in conjunction with specific embodiments.

[0030] Example 1

[0031] A compound fritillaria and loquat capsule A is prepared from the following raw materials by weight: 12g loquat leaf, 10g cinnamon twig, 12g codonopsis, 5g platycodon, 6g fritillaria, 6g pinellia, 5g tangerine peel, 2g dried ginger, and 0.5g menthol.

[0032] Example 2

[0033] A compound fritillaria and loquat capsule B is prepared from the following raw materials by weight: 10g loquat leaf, 10g cinnamon twig, 10g codonopsis, 6g platycodon, 5g fritillaria, 5g pinellia, 6g tangerine peel, 2g dried ginger, and 1g menthol.

[0034] Example 3

[0035] A compound fritillaria and loquat capsule C is prepared from the following raw materials by weight: 12g loquat leaf, 9g cinnamon twig, 12g codonopsis, 6g platycodon, 5g fritillaria, 6g pinellia, 6g tangerine peel, 3g dried ginger, and 1g menthol.

[0036] Example 4

[0037] A compound fritillaria and loquat capsule D is prepared from the following raw materials by weight: 12g loquat leaf, 10g cinnamon twig, 10g codonopsis, 5g platycodon, 6g fritillaria, 6g pinellia, 6g tangerine peel, 2g dried ginger, and 0.5g menthol.

[0038] Example 5

[0039] A compound fritillaria and loquat capsule E is prepared from the following raw materials by weight: 12g loquat leaf, 10g cinnamon twig, 12g codonopsis, 5g platycodon, 6g fritillaria, 6g pinellia, 6g tangerine peel, 2g dried ginger, and 0.5g menthol.

[0040] Comparative Example 1

[0041] A compound fritillaria and loquat capsule F is prepared from the following raw materials by weight:

[0042] Fritillaria cirrhosa 65g, Platycodon grandiflorus 65g, Eriobotrya japonica leaf 430g, and borneol 0.5g.

[0043] The preparation method is as follows: The above four ingredients are: Fritillaria cirrhosa powdered into fine powder; Platycodon grandiflorus powdered into fine powder; 48g of each ingredient are decocted twice with 10 times the amount of water, 1 hour each time, filtered in batches, the filtrates are combined, and left to stand for 12 hours. The supernatant is concentrated to a clear extract with a relative density of 1.20-1.25 (60℃), mixed with Platycodon grandiflorus powder, dried, ground into a fine powder, Fritillaria cirrhosa powdered into fine powder, mixed, granulated, dried, and then added with almond flavoring, menthol, and starch as needed, mixed, and filled into capsules. Each capsule is filled with about 0.3g to 0.5g of medicinal powder, and finally, Compound Fritillaria cirrhosa and Loquat Capsules F are obtained.

[0044] Example 6

[0045] A method for preparing compound fritillaria and loquat capsule AF, the specific steps of which are as follows:

[0046] According to the traditional Chinese medicine formulas described in Examples 1-5, weigh out the following medicinal materials that meet pharmacopoeia standards: loquat leaves, cinnamon twigs, platycodon root, fritillaria bulb, pinellia tuber, tangerine peel, and dried ginger, ensuring the materials are dry and free of impurities. Clean the materials thoroughly to remove dirt and impurities, avoiding contaminants that could affect efficacy. Slice or pulverize the cleaned materials to maximize surface area for subsequent extraction processes. Hard materials such as dried ginger and cinnamon twigs can be coarsely pulverized, while the remaining materials are cut into small pieces. Use purified water as the extraction solvent to extract the active ingredients from the materials. The extraction ratio is typically 1:10 (materials:water by weight).

[0047] First extraction: Add loquat leaves, cinnamon twigs, platycodon root, fritillaria bulb, pinellia tuber, dried tangerine peel, and dried ginger to an extraction tank, add 10 times the amount of water, bring to a boil over high heat, then reduce to low heat and maintain a boil for 2 hours.

[0048] Second extraction: After extraction, filter out the liquid, add water to 10 times the volume, bring to a boil, simmer over low heat for 1 hour, and extract again.

[0049] Combining the extracts: Combine the extracts from the two extractions, filter to remove the residue, and collect the clear liquid for later use. Concentrate the extracted liquid to a thick paste. Use a vacuum concentrator and concentrate at a temperature below 60℃ to avoid decomposition of the active ingredients due to high temperatures. Concentrate until the specific gravity of the liquid is approximately 1.2 (20% heavier than water), or until the volume is about 1 / 5 of the original weight of the medicinal materials, making it a thick paste.

[0050] The concentrated paste is placed in a spray dryer at a temperature controlled at 80-90℃ for spray drying, yielding a traditional Chinese medicine powder. The dried powder must have a moisture content below 5% to prevent deterioration during long-term storage of the capsules. Menthol is a volatile component and cannot be extracted at high temperatures. Menthol can be added to the dried powder, or dissolved in ethanol and then thoroughly mixed with the powder to ensure even distribution. Dissolved menthol can be sprayed onto the dried powder, mixed thoroughly, and then sealed for storage to prevent evaporation. All prepared powders (including those with added menthol) are mixed thoroughly. A mixer can be used to ensure uniform distribution of all components. The mixing time is approximately 20-30 minutes. After mixing, a sample is taken to check the uniformity of the powder, ensuring uniformity of components in each batch. Appropriate size 0 empty capsules are selected, and the evenly mixed powder is filled into the capsule shells. The filling amount needs to be precisely controlled; an automatic capsule filling machine can be used to ensure consistent drug dosage in each capsule. The weight of each capsule can be designed as needed, with each capsule filled with approximately 0.3g to 0.5g of medicinal powder, ultimately yielding Compound Fritillaria and Loquat Capsules AE.

[0051] Example 7: Compound Fritillaria and Loquat Capsules (AF) used to treat a mouse model of cold cough.

[0052] Adult male BALB / c mice typically weigh between 20 and 30 grams. Adult male BALB / c mice weighing approximately 20 grams were selected and divided into groups of 20. The experimental grouping and treatment were as follows:

[0053] Blank control group: No cold stimulation or cough induction was given, and normal living conditions were maintained. The animals were fed for 28 days.

[0054] Model group: Cold stimulation and ammonia water were used to induce coughing, and the cough response was observed. At the same time, an equal amount of physiological saline was administered by gavage for 28 consecutive days.

[0055] Group A (Capsule): Mice were given cold stimulation and cough induction treatment, and were simultaneously treated with Compound Fritillaria and Loquat Capsules A. Each mouse weighing approximately 20g was given a total daily dose of approximately 45mg of Compound Fritillaria and Loquat Capsules A. The therapeutic effect of the drug was observed after 28 days of continuous administration.

[0056] Group B of capsules: Cold stimulation and cough induction were performed, and compound fritillaria and loquat capsules B were administered simultaneously. Each mouse weighing approximately 20g should take approximately 45mg of compound fritillaria and loquat capsules B daily. The therapeutic effect of the drug was observed after 28 days of continuous administration.

[0057] Group C: Cold stimulation and cough induction were performed, and compound fritillaria and loquat capsules C were administered simultaneously. Each mouse, weighing approximately 20g, should receive a total daily dose of approximately 45mg of compound fritillaria and loquat capsules C. The therapeutic effect of the drug was observed after 28 days of continuous administration.

[0058] Group D (Capsule): Mice were given cold stimulation and cough induction, and were simultaneously treated with Compound Fritillaria and Loquat Capsules D. Each mouse weighing approximately 20g was given a total daily dose of approximately 45mg of Compound Fritillaria and Loquat Capsules D. The therapeutic effect of the drug was observed after 28 days of continuous administration.

[0059] Group E (Capsule): Mice were given cold stimulation and cough induction, and were simultaneously treated with Compound Fritillaria and Loquat Capsules E. Each mouse weighing approximately 20g was given a total daily dose of approximately 45mg of Compound Fritillaria and Loquat Capsules E. The therapeutic effect of the drug was observed after 28 days of continuous administration.

[0060] Group F (capsule): The mice were subjected to cold stimulation and cough induction, and were simultaneously treated with Compound Fritillaria and Loquat Capsules F. Each mouse weighing approximately 20g was given a total of approximately 45mg of Compound Fritillaria and Loquat Capsules E per day. The therapeutic effect of the drug was observed after 28 days of continuous administration.

[0061] Positive control group: Cold stimulation and cough induction were performed, and the mice were treated with the positive control drug ambroxol. Each mouse weighing about 20g was given 0.09mg of ambroxol daily for 28 days to observe the therapeutic effect of the drug.

[0062] Cold water swimming provides a cold stimulus:

[0063] Adult male BALB / c mice were placed in 4°C cold water for 5 minutes to simulate the cold response of mice after cold exposure. Cold stimulation can induce cold cough symptoms in the mouse's immune system and respiratory tract. After removal, the mice were quickly dried and returned to their normal living environment to prevent infection.

[0064] Ammonia stimulation method for inducing cough:

[0065] BALB / c mice, after undergoing cold stimulation, were placed in a sealed stimulation chamber. Ammonia solution with a concentration of 0.25%–0.3% was sprayed into the chamber via a nebulizer, allowing the mice to inhale the solution. Each ammonia injection lasted 30 seconds. The cough response of each mouse was observed and recorded. The cough response typically appeared within 2–3 minutes and lasted for approximately 10 minutes. The cough latency and the number of coughs within 2 minutes were observed and recorded.

[0066] The effects of compound fritillaria and loquat capsules on the body weight of mice induced by cold stimulation and cough were investigated. The changes in the initial body weight of mice in each experimental group were recorded, as shown in Table 1.

[0067] Table 1. Effects of Compound Fritillaria and Loquat Capsules on Body Weight in Mouse Models Induced by Cold Stimulation and Cough (Mean ± Standard Deviation, n = 20)

[0068] Group Final body weight / g Blank control group 23.25±1.62 Model group <![CDATA[13.37±1.37 a ]]> Capsule Group A <![CDATA[21.67±1.05 c ]]> Capsule Group B <![CDATA[22.55±1.26 d ]]> Capsule Group C <![CDATA[23.56±1.72 d ]]> Capsule Group D <![CDATA[21.42±1.24 c ]]> Capsule Group E <![CDATA[22.34±1.21 c ]]> Capsule F group <![CDATA[18.45±1.92 d ]]> Positive control group <![CDATA[17.82±1.28 d ]]>

[0069] Note: Compared with the blank control group, a P < 0.05 b P < 0.01; compared with the model group, c P < 0.05 d P < 0.01.

[0070] Table 1 shows that, compared with the blank control group, the weight gain rate of mice in the model group was significantly reduced (P < 0.05); compared with the model group, the weight gain rate of mice in the capsule AF group was significantly increased (P < 0.05 or P < 0.01), and the capsule AE group had a significantly better effect on increasing the weight gain rate of mice than the capsule F group. This indicates that the compound fritillaria and loquat capsule of the present invention has a significant effect on improving the weight gain of mice induced by cold stimulation and cough.

[0071] The effects of Compound Fritillaria and Loquat Capsules on the latency of cough induced by cold stimulation and cough and the number of coughs within 2 minutes in mice are shown in Table 2.

[0072] Table 2. Effects of Compound Fritillaria and Loquat Capsules on Cough Latency and Cough Frequency in Mice with Cold Cough (Mean ± Standard Deviation, n = 20)

[0073] Group Cough incubation period / s Number of coughs Model group 19.25±2.73 59.32±4.81 Capsule Group A <![CDATA[32.39±3.26 c ]]> <![CDATA[34.39±4.25 d ]]> Capsule Group B <![CDATA[33.49±3.28 c ]]> <![CDATA[32.19±3.95 d ]]> Capsule Group C <![CDATA[32.15±4.46 d ]]> <![CDATA[35.68±3.22 c ]]> Capsule Group D <![CDATA[31.42±3.74 c ]]> <![CDATA[30.43±4.47 c ]]> Capsule Group E <![CDATA[34.52±3.39 c ]]> <![CDATA[29.45±3.76 d ]]> Capsule F group <![CDATA[27.41±4.81 c ]]> <![CDATA[38.54±5.86 d <!-- 5 -->]]> Positive control group <![CDATA[28.29±2.95 d ]]> <![CDATA[41.56±3.43 c ]]>

[0074] Note: Compared with the model group, c P < 0.05 d P < 0.01.

[0075] Table 2 shows that, compared with the model group, the cough latency period of mice in the capsule AF group was significantly prolonged (P<0.05 or P<0.01); the number of coughs in mice in each treatment group was significantly reduced compared with the model group (P<0.05 or P<0.01), and the capsule AE group was significantly better than the capsule F group and the positive control group in prolonging the cough latency period and reducing the number of coughs in mice with cold cough. That is, the compound fritillaria and loquat capsule AE of the present invention significantly prolongs the cough latency period and reduces the number of coughs in mice with cold cough, and has a significant antitussive effect.

[0076] Establishment of a mouse model of phenol red excretion in the trachea for cold cough: Mice in the successfully established model group, capsule AF group, and positive control group were administered the drugs according to the requirements of each group for 28 consecutive days. One hour after the last administration, mice were intraperitoneally injected with 20 mL / kg of 5% phenol red saline solution. After 30 minutes, the trachea was removed and placed in 4 mL of saline solution, and 0.2 mL of 5% sodium bicarbonate solution was added. The mixture was shaken to completely release the phenol red from the trachea. The OD value was measured at 546 nm, and the excretion amount of phenol red was calculated according to the standard curve of phenol red, as shown in Table 3.

[0077] Table 3. Effect of Compound Fritillaria and Loquat Capsules on Tracheal Phenol Red Secretion in Mice with Cold Cough (Mean ± Standard Deviation, n = 20)

[0078] Group Phenol red excretion (ng / mL) Model group 1.63±0.48 Capsule Group A <![CDATA[4.58±0.52 c ]]> Capsule Group B <![CDATA[4.34±0.39 c ]]> Capsule Group C <![CDATA[4.37±0.58 d ]]>

Claims

1. A compound fritillaria and loquat capsule, prepared from the following raw materials by weight: 10-12g loquat leaf, 9-10g cinnamon twig, 10-12g codonopsis, 5-6g platycodon, 5-6g fritillaria, 5-6g pinellia, 5-6g tangerine peel, 2-3g dried ginger, and 0.5-1g menthol.

2. The compound fritillaria and loquat capsule according to claim 1, characterized in that, The compound fritillaria and loquat capsules are prepared from the following raw materials by weight: 12g loquat leaves, 10g cinnamon twigs, 12g codonopsis, 5g platycodon, 6g fritillaria, 6g pinellia, 5g tangerine peel, 2g dried ginger, and 0.5g menthol.

3. The compound fritillaria and loquat capsule according to claim 1, characterized in that, The compound fritillaria and loquat capsules are prepared from the following raw materials by weight: 10g loquat leaves, 10g cinnamon twigs, 10g codonopsis, 6g platycodon, 5g fritillaria, 5g pinellia, 6g tangerine peel, 2g dried ginger, and 1g menthol.

4. The compound fritillaria and loquat capsule according to claim 1, characterized in that, The compound fritillaria and loquat capsules are prepared from the following raw materials by weight: 12g loquat leaves, 9g cinnamon twigs, 12g codonopsis, 6g platycodon, 5g fritillaria, 6g pinellia, 6g tangerine peel, 3g dried ginger, and 1g menthol.

5. The compound fritillaria and loquat capsule according to claim 1, characterized in that, The compound fritillaria and loquat capsules are prepared from the following raw materials by weight: 12g loquat leaves, 10g cinnamon twigs, 10g codonopsis, 5g platycodon, 6g fritillaria, 6g pinellia, 6g tangerine peel, 2g dried ginger, and 0.5g menthol.

6. The compound fritillaria and loquat capsule according to claim 1, characterized in that, The compound fritillaria and loquat capsules are prepared from the following raw materials by weight: 12g loquat leaves, 10g cinnamon twigs, 12g codonopsis, 5g platycodon, 6g fritillaria, 6g pinellia, 6g tangerine peel, 2g dried ginger, and 0.5g menthol.

7. The use of the compound fritillaria and loquat capsules according to any one of claims 1-6 in the preparation of a medicine for treating cough due to cold.