Levocarnitine injection and preparation device thereof

Abstract

The invention relates to the technical field of levocarnitine injection preparation devices, in particular to a levocarnitine injection and a preparation device thereof. Comprising the following raw materials in percentage by mass: 18%-22% of levocarnitine, 5%-10% of a vitamin antioxidant, 28%-33% of a traditional Chinese medicine extract, a pH regulator and the balance of water for injection, the traditional Chinese medicine composition is prepared from the following components in percentage by mass: 10% of ginseng extract, 10% of fructus lycii extract, 20% of radix astragali extract, 10% of radix salviae miltiorrhizae extract, 8% of fructus schisandrae chinensis extract, 14% of radix notoginseng extract and the balance of pure water. Through combined use of levocarnitine and traditional Chinese medicines, it is found that mixed injection of levocarnitine, the vitamin antioxidant and the traditional Chinese medicine extract has a better treatment effect than independent injection, and the mixed injection shows a more remarkable synergistic effect.

Description

Technical Field

[0001] The invention relates to the technical field of L-carnitine injection preparation devices, in particular to L-carnitine injection and a preparation device thereof. Background Art

[0002] L-Carnitine, also known as carnitine, is a compound that occurs naturally in mammals and is primarily synthesized by the liver and kidneys. It is essential for energy metabolism, especially the oxidation of fatty acids. On the one hand, L-Carnitine can carry long-chain fatty acids into the mitochondrial matrix and support the oxidative decomposition of these fatty acids, thereby providing the cells with the necessary energy; on the other hand, it is also responsible for transporting out the short-chain acyl groups produced in the mitochondria.

[0003] For people whose renal function is gradually impaired (such as patients with renal failure), the kidney's ability to synthesize L-carnitine will gradually decrease, resulting in a decrease in the level of L-carnitine in the body, which in turn leads to complications such as cardiomyopathy, skeletal myopathy, arrhythmia, hyperlipidemia, hypotension, and muscle cramps during dialysis. Therefore, for such patients, L-carnitine injection can be used to relieve these symptoms caused by carnitine deficiency and improve the patient's quality of life.

[0004] Traditionally, the preparation process of L-carnitine injection involves dissolving L-carnitine in water for injection, adding an appropriate amount of activated carbon to the water for injection to remove impurities generated during the preparation process, then filtering to remove the activated carbon and impurities generated to ensure the clarity of the solution, and then filling the filtered filtrate and sterilizing it at high temperature to obtain the finished L-carnitine injection. However, after detailed research, it was found that when L-carnitine injection is prepared using the above conventional preparation method, L-carnitine may undergo a certain degree of degradation during the processing process, resulting in a higher content of trimethylamine in the final product. Given the potential toxicity of trimethylamine, its presence may pose a risk to human health. Therefore, exploring methods to reduce the content of trimethylamine in L-carnitine injection is crucial to improving the safety of this drug. Summary of the invention

[0005] In order to overcome the shortcomings existing in the current process of preparing L-carnitine injection, the present invention provides a L-carnitine injection and a preparation device thereof.

[0006] A L-carnitine injection, comprising the following raw materials: 18%-22% of L-carnitine by mass, 5%-10% of vitamin antioxidant by mass, 28%-33% of Chinese herbal extract by mass, pH regulator and water for injection to make up the rest; the Chinese herbal extract includes the following raw materials: 10% by weight of ginseng extract, 10% by weight of wolfberry extract, 20% by weight of astragalus extract, 10% by weight of salvia miltiorrhiza extract, 8% by weight of schisandra chinensis extract, 14% by weight of panax notoginseng extract and the balance made up of pure water.

[0007] A device for preparing a L-carnitine injection, based on the above-mentioned L-carnitine injection, comprises: A bracket, on which a liquid storage tank is fixedly connected, and the liquid storage tank is equipped with a connecting piece; A rotating tube, sealed and rotatably connected to the liquid storage tank, a driving module is arranged between the liquid storage tank and the rotating tube; An end cover is mounted on the connecting piece of the liquid storage tank, and the rotating tube passes through the end cover and is rotatably connected thereto; A sealing ring, rotatably connected to the end cover, wherein the sealing ring is rotatably connected to the liquid storage tank; A fixed shell, fixedly connected to the sealing ring, wherein the fixed shell is slidably connected to the liquid storage tank; A plurality of samplers are provided on the rotating tube, wherein the samplers are rotationally connected to a sealing member, and the sealing member is rotationally connected to the fixed shell; A mounting member, detachably connected to the interior of the rotating tube, wherein the mounting member is detachably connected to a plurality of liquid storage tanks, the number of the liquid storage tanks being consistent with the number of the samplers, and the liquid storage tanks being communicated with adjacent samplers; A trigger assembly is arranged on the liquid storage tank, and the trigger assembly is used to change the positions of all the sealing components.

[0008] It is further explained that the sampler and the seal are both composed of a circular plate portion and a symmetrically distributed arc portion, the central angle corresponding to the arc portion on the sampler is equal to 90°, and the central angle corresponding to the arc portion on the seal is greater than 90°. When the seal rotates 90°, the seal and the adjacent sampler form a cavity together.

[0009] Further description, the trigger component includes: A first electric push rod is installed on the outside of the liquid storage tank; A first movable ring, slidably connected to the sealing ring, and the first movable ring is slidably connected to the telescopic end of the first electric push rod; The driving rod is fixedly connected to one side of the first movable ring close to the fixed shell, and the driving rod slides in the fixed shell. The sealing member is fixedly connected to a driving gear located in the fixed shell, and a rack meshing with the driving gear is installed on the driving rod.

[0010] Further explanation includes: A plurality of partition assemblies, the number of which is the same as the number of the sealing members, the partition assemblies are used to separate the samples taken, the partition assemblies are arranged between the sampler and the rotating tube, and the partition assemblies include: A plurality of partition plates, all of which are fixedly connected to the adjacent samplers, the partition plates close to the central axis of the liquid storage tank pass through the rotating tube and are rotatably connected thereto, the sealing member is slidably connected to the partition plates, the plurality of partition plates divide the cavity formed by the sampler and the sealing member into a plurality of sample storage cavities, and the liquid storage tank is provided with the same number of liquid storage cavities as the number of the partition plates; A plurality of liquid discharge pipes, the number of which is the same as the number of the partition plates, are fixedly connected to the sampler, and the liquid discharge pipes are communicated with adjacent sample storage cavities on the sampler; A plurality of liquid inlet pipes, the number of which is the same as the number of the partition plates, are all fixedly connected to the liquid storage tank, the liquid inlet pipes are communicated with the adjacent liquid discharge pipes, and the plurality of liquid inlet pipes are respectively communicated with the plurality of liquid storage chambers.

[0011] It is further explained that the sampler is provided with a plurality of conical surfaces, and the specific number of the conical surfaces on the sampler is the same as the specific number of the partition plates thereon, which are used to guide the flow of the sample in the sampler.

[0012] Further explanation includes: An exhaust pipe is installed in the rotating tube, and a plurality of branch pipes are arranged on the exhaust pipe. The number of the branch pipes on the exhaust pipe is the same as the number of the liquid storage tanks. The branch pipes on the exhaust pipe are fixedly connected to the adjacent liquid storage tanks, and the branch pipes on the exhaust pipe are connected to all the liquid storage cavities on the adjacent liquid storage tanks.

[0013] Further explanation includes: A plugging assembly is disposed between the sampler and the rotating tube, and is used to change the flow relationship of all the drainage pipes. The plugging assembly includes: A blocking plate, slidably connected in the rotating tube, the blocking plate is used to change the flow relationship of all the drainage pipes; A second movable ring, slidably connected to the blocking plate; A second electric push rod is fixedly connected to the end cover, and a telescopic end of the second electric push rod is fixedly connected to the second movable ring, and the blocking plate is provided with storage cavities having the same number as the samplers; A plurality of transfer tubes, the number of which is the same as the number of the drainage tubes, are respectively fixed in adjacent storage cavities on the blocking plate; two symmetrically distributed tube connectors are slidably connected in the storage cavity of the blocking plate; the tube connectors are slidably connected to the transfer tubes; the two tube connectors and the adjacent transfer tubes jointly connect the drainage tube with the adjacent liquid inlet tube; a first elastic member is fixed between the tube connector and the blocking plate.

[0014] Further explanation includes: The expansion component is arranged between the liquid storage tank and the sealing member, and is used to change the volume of the sample storage cavity on all the samplers, and the expansion component includes: A plurality of sealing plates, the number of which is the same as the number of the partition plates, are respectively fixed to a side of the adjacent partition plates away from the central axis of the liquid storage tank, and the partition plates are provided with liquid storage cavities; A plurality of movable plates, the number of which is the same as the number of the partition plates, are respectively slidably connected in adjacent liquid storage chambers, the movable plates are fixedly connected to adjacent sealing plates, a second elastic member is fixedly connected between the movable plates and the adjacent partition plates, and the movable plates are sealingly and slidably connected to adjacent liquid discharge pipes; The liquid pumping tube is fixedly connected in the fixed shell, and the liquid pumping tube is sealingly and slidably connected with the movable plate, and the liquid pumping tube is communicated with all the liquid storage chambers.

[0015] Further description, the expansion component also includes: A liquid storage ring is fixedly connected to the upper side of the first movable ring, and the liquid extraction tube passes through the sealing ring, the fixed shell and the first movable ring to communicate with the liquid storage ring; A rotating plate is slidably connected to the end cover, the rotating plate rotates in the liquid storage ring, a hydraulic pump is arranged on the end cover, and a hose connected to the liquid storage ring is fixedly connected between the hydraulic pump on the end cover and the rotating plate.

[0016] The beneficial effects of the present invention are as follows: the present invention combines L-carnitine with traditional Chinese medicine, and through further experiments, not only expands the types of traditional Chinese medicine that can be used in combination and forms a synergistic compound, but also finds that the mixed injection of L-carnitine, vitamin antioxidants and traditional Chinese medicine extracts has a better therapeutic effect than single injection, and the mixed injection shows a more significant synergistic effect.

[0017] During the stirring process, the seal rotates to seal part of the raw materials in the cavity formed by the sampler and the seal, thereby completing the sampling of the raw materials in the liquid storage tank. There is no need to shut down the drive module, making the whole process faster and more convenient, ensuring the normal stirring work, reducing the impact of sampling on the stirring efficiency, and reducing the impact on the flow state of the raw materials in the liquid storage tank, thereby improving the representativeness and accuracy of the samples.

[0018] The taken samples are stored separately through partition plates to avoid mixing of the taken samples during the flow process, which would lead to a decrease in the accuracy of the test results. The layered samples are stored in separate liquid storage chambers, and the samples in different liquid storage chambers are tested separately, which further increases the representativeness of the taken samples and the accuracy of the sample test results.

[0019] By increasing the volume of the first sample storage chamber and the second sample storage chamber, and thereby reducing the pressure inside the first sample storage chamber and the second sample storage chamber, the gas dissolved in the raw material can more easily form bubbles and expand rapidly, thereby accelerating the rising speed of the bubbles, reducing the gas content in the sample taken, preventing the bubbles from affecting the sample detection results, and further increasing the accuracy of the sample detection results. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a schematic diagram of the three-dimensional structure of the present invention; Figure 2 It is a three-dimensional structural cross-sectional view of the liquid storage tank of the present invention; Figure 3 It is a three-dimensional structural cross-sectional view of the rotating tube and the end cover of the present invention; Figure 4 It is a schematic diagram of the three-dimensional structure of the fixed shell of the present invention; Figure 5 is a cross-sectional view of the three-dimensional structure of the sampler of the present invention; Figure 6 is a three-dimensional structural cross-sectional view of the partition plate of the present invention; Figure 7 It is a three-dimensional structural cross-sectional view of the partition plate and the drain pipe of the present invention; Figure 8 It is a schematic diagram of the three-dimensional structure of the liquid storage chamber and the second elastic member of the present invention; Fig. 9 It is a three-dimensional structural cross-sectional view of the sampler and the sealing member of the present invention; Fig.10 It is a three-dimensional structural cross-sectional view of the liquid storage chamber and the sealing plate of the present invention; Fig.11 It is a three-dimensional structural cross-sectional view of the liquid discharge pipe, the liquid inlet pipe and the pipe connector of the present invention; Fig.12 It is a three-dimensional structural cross-sectional view of the liquid storage ring and the rotating plate of the present invention; Fig.13 It is an exploded view of the three-dimensional structure of the liquid discharge pipe and the pipe connector of the present invention.

[0021] The names and serial numbers of the parts in the figure are: 1: bracket, 2: liquid storage tank, 3: rotating tube, 4: end cover, 5: sealing ring, 6: fixed shell, 7: sampler, 8: sealing member, 81: mounting member, 82: liquid storage tank, 9: first electric push rod, 10: first moving ring, 11: driving rod, 12: driving gear, 13: partition plate, 15: liquid storage chamber, 16: liquid discharge pipe, 17: liquid inlet pipe, 18: exhaust pipe, 19: blocking plate, 20: second moving ring, 21: second electric push rod, 22: transfer pipe, 23: tube connector, 24: first elastic member, 25: sealing plate, 26: liquid storage chamber, 27: moving plate, 28: second elastic member, 29: liquid extraction pipe, 30: liquid storage ring, 31: rotating plate. DETAILED DESCRIPTION

[0022] The present invention will now be described more fully below with reference to the accompanying drawings, in which currently preferred embodiments of the present invention are shown. However, the present invention may be implemented in many different forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided for thoroughness and completeness, and these embodiments fully convey the scope of the present invention to the skilled person.

[0023] Embodiment 1: A L-carnitine injection, comprising the following raw materials: 18%-22% of L-carnitine by mass, 5%-10% of vitamin antioxidant by mass, 28%-33% of Chinese herbal extract by mass, pH regulator and water for injection to make up the rest; the Chinese herbal extract includes the following raw materials: 10% by weight of ginseng extract, 10% by weight of wolfberry extract, 20% by weight of astragalus extract, 10% by weight of salvia miltiorrhiza extract, 8% by weight of schisandra chinensis extract, 14% by weight of panax notoginseng extract and the balance made up of pure water.

[0024] Embodiment 2: In the process of preparing L-carnitine injection, it is necessary to add a variety of raw materials into a reactor in sequence, and stir the various raw materials to increase the mixing uniformity of the various raw materials in the reactor, and it is necessary to sample and detect the raw materials in the reactor during the stirring process to determine the mixing state of the raw materials in the reactor. Most of the current reactors need to sample and detect after stopping stirring, which affects the stirring efficiency, and it is necessary to take samples of different depths for detection multiple times during sampling and detection, which is cumbersome to operate. For the above problems, the present invention solves them by the following measures: On the basis of Example 1, a device for preparing L-carnitine injection, based on the above-mentioned L-carnitine injection, such as Figure 1-Figure 5As shown, the device includes: a bracket 1, on which a liquid storage tank 2 is fixedly connected, and the liquid storage tank 2 is installed with a connecting piece; a rotating tube 3, which is sealed and rotatably connected to the liquid storage tank 2, and a driving module is arranged between the liquid storage tank 2 and the rotating tube 3; an end cover 4, which is installed on the connecting piece of the liquid storage tank 2, and the rotating tube 3 passes through the end cover 4 and is rotatably connected thereto; a sealing ring 5, which is rotatably connected to the end cover 4, and the sealing ring 5 is rotatably connected to the liquid storage tank 2; a fixed shell 6, which is fixed to the sealing ring 5, and the fixed shell 6 is slidably connected to the liquid storage tank 2; a plurality of samplers 7, all of which are arranged on the rotating tube 3, and the sampler 7 is rotatably connected to a sealing piece 8, and the sealing piece 8 is rotatably connected to the fixed shell 6, and the sampler 7 cooperates with the sealing piece 8 to form a cavity for storing a sample, and the sampler 7 and the sealing piece 8 cooperate to form a cavity for storing a sample, and the sampler 7 and The seals 8 are composed of a circular plate portion and a symmetrically distributed arc portion. The central angle corresponding to the arc portion on the sampler 7 is equal to 90°, which is used to increase the volume of the sample taken by the sampler 7 at a single time. The central angle corresponding to the arc portion on the seal 8 is greater than 90°, which is used to increase the sealing between the sampler 7 and the seal 8. When the seal 8 rotates 90°, the seal 8 and the adjacent sampler 7 form a cavity together; the mounting member 81 is detachably connected to the inside of the rotating tube 3, and the mounting member 81 is detachably connected to a plurality of liquid storage tanks 82. The number of liquid storage tanks 82 is consistent with the number of samplers 7, and the liquid storage tanks 82 are connected to the adjacent samplers 7; the trigger component is arranged on the liquid storage tank 2, and the trigger component is used to change the position of all seals 8.

[0025] In the above scheme, the driving module between the liquid storage tank 2 and the rotating tube 3 is an existing device, which is not shown in the figure. When in use, it can be selected as a combination of a motor and a reducer, and the driving module is used to drive the rotating tube 3 to rotate; the rotating tube 3 and the end cover 4 and the end cover 4 and the sealing ring 5 are not sealed, which are used to discharge the oxygen contained in the raw materials in the liquid storage tank 2; the fixed shell 6 moves along the inner wall of the liquid storage tank 2; the specific number of samplers 7 can be selected by the staff during specific use, and the distance between two adjacent samplers 7 can also be selected by the staff. The figure and the text are both represented by taking three samplers 7 distributed equidistantly as an example; the circular plate portion on the sampler 7 is located near the central axis of the liquid storage tank 2 On one side, the circular plate portion on the seal 8 is located on the side of the seal 8 away from the central axis of the liquid storage tank 2. In the present embodiment, the circular plate portion on the sampler 7 passes through the rotating tube 3 and is fixed thereto; initially, the sampler 7 and the two arc-shaped portions on the seal 8 are respectively located on the upper and lower sides, and by changing the relative position of the sampler 7 and the adjacent seal 8, the two arc-shaped portions of the sampler 7 and the two arc-shaped portions of the adjacent seal 8 form a cavity together; the liquid storage tanks 82 are also represented in the figure and the text by taking three equidistantly distributed as an example; in the present embodiment, the three liquid storage tanks 82 can be connected to the adjacent samplers 7 through a hose, the three liquid storage tanks 82 are connected through a hose, and the hoses on the three liquid storage tanks 82 are externally connected to an external gas supply device.

[0026] When using the device to prepare L-carnitine injection, the staff will put a certain amount of L-carnitine powder, water for injection and other additives into the liquid storage tank 2 in sequence (hereinafter referred to as raw materials to refer to the various materials in the liquid storage tank 2). After the addition is completed, the staff will start the driving module, and the driving module will drive the rotating tube 3 to rotate, and then the rotating tube 3 will drive the three samplers 7 on it and the fixed shell 6 and the three sealing members 8 on the fixed shell 6 to rotate synchronously, so as to stir the raw materials in the liquid storage tank 2 to increase the mixing speed of the raw materials in the liquid storage tank 2. Then the staff will control the external gas transmission device to transport nitrogen into the three liquid storage tanks 82, and then transport nitrogen into the liquid storage tank 2 through the three liquid storage tanks 82 to remove the oxygen contained in the raw materials in the liquid storage tank 2.

[0027] The following description is made by taking the movement process of the uppermost seal 8 as an example: After the raw materials in the liquid storage tank 2 are mixed for a period of time, the staff shuts down the external gas supply device and controls the trigger component to work. The trigger component drives the seal 8 to rotate 90°, and the two arc-shaped parts of the seal 8 are converted from being located on the upper and lower sides to being located on the front and rear sides. The seal 8 seals the gap between the two arc-shaped parts of the sampler 7 to form a cavity, and then part of the raw materials are sealed in the cavity formed by the sampler 7 and the seal 8 to complete the sampling of the raw materials in the liquid storage tank 2 (at this time, part of the nitrogen exists in the liquid storage tank 82 and the hose between the liquid storage tank 82 and the seal 8, so that the sample taken cannot flow due to the blockage of this part of the nitrogen). There is no need to shut down the drive module, which makes the whole process faster and more convenient, and can ensure the normal progress of the stirring work, reduce the influence of sampling on the stirring efficiency, thereby reducing the influence on the flow state of the raw materials in the liquid storage tank 2, and improve the representativeness and accuracy of the sample.

[0028] After the sampling is completed, the staff controls the external gas supply device to extract the nitrogen remaining in the liquid storage tank 82 and the hose between the liquid storage tank 82 and the sealing member 8, and causes the sample in the cavity of the sealing member 8 to flow into the liquid storage tank 82 under suction. Subsequently, the staff takes out the mounting member 81 and the three liquid storage tanks 82 simultaneously, and replaces the liquid storage tank 82 containing the sample for subsequent use. At the same time, the taken out samples are tested to determine the mixing state of the raw materials in the liquid storage tank 2, and then determine whether the raw materials in the liquid storage tank 2 are mixed.

[0029] After the three liquid storage tanks 82 are replaced as mentioned above, if the raw materials in the liquid storage tank 2 are not mixed completely, the staff will reset the mounting member 81 to the initial position and control the trigger assembly to reset the three sealing members 8 to the initial position to continue stirring the raw materials in the liquid storage tank 2. If the stirring of the raw materials in the liquid storage tank 2 is completed, the staff will shut down the driving module and release the raw materials in the liquid storage tank 2. The staff will then clean the liquid storage tank 2 for subsequent use.

[0030] Further, such as Figure 1-Figure 5 As shown, the trigger assembly includes: a first electric push rod 9, installed on the outside of the liquid storage tank 2; a first movable ring 10, slidably connected to the sealing ring 5, and the first movable ring 10 is slidably connected to the telescopic end of the first electric push rod 9; a driving rod 11, fixedly connected to the side of the first movable ring 10 close to the fixed shell 6, and the driving rod 11 slides in the fixed shell 6, the sealing member 8 is fixedly connected to the driving gear 12 in the fixed shell 6, and a rack meshing with the driving gear 12 is installed on the driving rod 11.

[0031] In the above scheme, the first electric push rod 9 is located on the left side of the liquid storage tank 2, and the telescopic end of the first electric push rod 9 is in an extended state at the beginning; the first moving ring 10 is located above the liquid storage tank 2, and the driving rod 11 is located on the lower side of the first moving ring 10. In the process of the above-mentioned rotating tube 3 driving the fixed shell 6 to rotate, the fixed shell 6 drives the sealing ring 5 to rotate, and the sealing ring 5 drives the first moving ring 10 to rotate synchronously. When the above-mentioned trigger component is working, the telescopic end of the first electric push rod 9 drives the first moving ring 10 to move downward, and the first moving ring 10 drives the driving rod 11 and the rack on the driving rod 11 to move downward synchronously, and the rack on the driving rod 11 drives the adjacent driving gear 12 to rotate, so as to drive the three sealing members 8 to rotate synchronously, until the telescopic end of the first electric push rod 9 is completely retracted into its fixed part, the driving rod 11 moves downward to the limit position, and the three sealing members 8 rotate synchronously by 90°. After the above-mentioned sampling is completed, the telescopic end of the first electric push rod 9 drives the first moving ring 10 to reset upward, and then resets the three sealing members 8 to the initial position for subsequent use.

[0032] Embodiment 3: Based on embodiment 2, Figure 3-Figure 9 As shown, it also includes: a number of partition components, the number of which is the same as the number of seals 8, the partition components are used to separate the samples taken, the partition components are arranged between the sampler 7 and the rotating tube 3, the partition components include: a number of partition plates 13, all of which are fixedly connected to adjacent samplers 7, the partition plates 13 close to the central axis of the liquid storage tank 2 pass through the rotating tube 3 and are rotatably connected thereto, the seal 8 is slidably connected to the partition plates 13, the several partition plates 13 divide the cavity formed by the sampler 7 and the seal 8 into a number of sample storage cavities, and the liquid storage tank 82 is provided with liquid storage cavities 15 of the same number as the number of the partition plates 13; a number of drainage pipes 16, the number of which is the same as the number of the drainage pipes 13, all of which are fixedly connected to the sampler 7, and the drainage pipes 16 are connected to the adjacent sample storage cavities on the sampler 7; a number of inlet pipes 17, the number of which is the same as the number of the partition plates 13, all of which are fixedly connected to the liquid storage tank 82, the inlet pipes 17 are connected to the adjacent drainage pipes 16, and the several inlet pipes 17 are respectively connected to the several liquid storage cavities 15.

[0033] In the above scheme, the specific number of partition plates 13, liquid storage chambers 15, liquid discharge pipes 16 and liquid inlet pipes 17 in the same partition assembly can be specifically selected by the staff. The figure and the text both take two as an example; one of the partition plates 13 is located in the middle of the arc-shaped portion of the same sampler 7, and the other partition plate 13 is located on the side of the circular plate portion of the sampler 7 close to the fixed shell 6 and is rotatably connected to the rotating tube 3; the two partition plates 13 divide the cavity formed by the sampler 7 and the sealing member 8 into two sample storage chambers. In the subsequent description of the text, the first sample storage chamber refers to the sample storage chamber close to the central axis of the liquid storage tank 2, and the second sample storage chamber refers to the other sample storage chamber; the first sample storage chamber and the second sample storage chamber on the same sampler 7 are respectively connected to the adjacent drainage pipes 16; the two liquid storage chambers 15 on the same liquid storage tank 82 are distributed on the left and right, and the raw material sample stored in the first sample storage chamber on the sampler 7 flows to the liquid storage chamber 15 on the right, and the raw material sample stored in the second sample storage chamber on the sampler 7 flows to the liquid storage chamber 15 on the left.

[0034] The following is described by taking the workflow of the upper side sampler 7 and other parts connected thereto as an example: During the rotation of the above-mentioned sealing member 8, the sealing member 8 rotates along the two partition plates 13, and the taken samples are divided into two parts, and are respectively stored in the first sample storage chamber and the second sample storage chamber on the same sampler 7. The taken samples are stored separately to avoid the taken samples from being mixed again during the flow process, which would cause a decrease in the accuracy of the test results. The raw material sample in the first sample storage chamber on the sampler 7 flows to the liquid storage chamber 15 on the right, and the raw material sample in the second sample storage chamber on the sampler 7 flows to the liquid storage chamber 15 on the left, and the samples in the two liquid storage chambers 15 are tested separately, which further increases the representativeness of the taken samples and the accuracy of the sample test results.

[0035] Furthermore, Figure 6 and Figure 7 As shown, the sampler 7 is provided with a plurality of conical surfaces, and the specific number of the conical surfaces on the sampler 7 is the same as the specific number of the partition plates 13 thereon, which are used to guide the flow of the raw material sample in the sampler 7. In the above scheme, two conical surfaces are provided on the same sampler 7, and the lowest point of the conical surface on the sampler 7 is located at the connection point between the sampler 7 and the drain pipe 16, which is used to increase the flow rate of the sample and reduce the residual sample in the sampler 7.

[0036] Furthermore, Figure 3-Figure 5 and Fig.10As shown, it also includes: an exhaust pipe 18, which is installed in the rotating tube 3. The exhaust pipe 18 is provided with a plurality of branch pipes. The number of the branch pipes on the exhaust pipe 18 is the same as the number of the liquid storage tanks 82. The branch pipes on the exhaust pipe 18 are fixedly connected to the adjacent liquid storage tanks 82, and the branch pipes on the exhaust pipe 18 are connected to all the liquid storage cavities 15 on the adjacent liquid storage tanks 82.

[0037] In the above scheme, the exhaust pipe 18 is connected to the gas delivery device; the number of branches on the exhaust pipe 18 is specifically selected by the staff when in use, and three are used as an example in the figure and the text, and the branches on the exhaust pipe 18 are connected to two adjacent liquid storage chambers 15; in the process of the above-mentioned driving module driving the rotating tube 3 to rotate, the gas delivery device delivers nitrogen to the three liquid storage tanks 82 through the exhaust pipe 18, and then delivers nitrogen to the liquid storage tank 2.

[0038] Furthermore, Figure 3-Figure 7 , Fig.10 and Fig.11 As shown, it also includes: a plugging component, which is arranged between the sampler 7 and the rotating tube 3, and the plugging component is used to change the flow relationship of all the drainage pipes 16. The plugging component includes: a plugging plate 19, which is slidably connected to the rotating tube 3, and the plugging plate 19 is used to change the flow relationship of all the drainage pipes 16; a second moving ring 20, which is slidably connected to the plugging plate 19; a second electric push rod 21, which is fixed to the end cover 4, and the telescopic end of the second electric push rod 21 is fixed to the second moving ring 20, and the plugging plate 19 is set There are storage cavities with the same number as the samplers 7; a number of transfer tubes 22, the same number as the number of drainage tubes 16, which are respectively fixed in adjacent storage cavities on the sealing plate 19, and two symmetrically distributed pipe connectors 23 are slidably connected in the storage cavity of the sealing plate 19, and the pipe connectors 23 are slidably connected to the transfer tubes 22. The two pipe connectors 23 and the adjacent transfer tubes 22 jointly connect the drainage tube 16 with the adjacent liquid inlet tube 17, and a first elastic member 24 is fixed between the pipe connector 23 and the sealing plate 19.

[0039] In the above scheme, the second electric push rod 21 is located on the upper side of the end cover 4; the storage cavity on the sealing plate 19 is provided with three linear arrays, the two transfer tubes 22 are symmetrically distributed front and back, and the two pipe connectors 23 are symmetrically distributed left and right; the first elastic member 24 is a spring, and the two first elastic members 24 are symmetrically distributed left and right; in order to increase the sealing between the discharge pipe 16 and the adjacent pipe connector 23 and the sealing between the inlet pipe 17 and the adjacent pipe connector 23, an inclined surface can be provided at the contact position of the discharge pipe 16, the inlet pipe 17 and the pipe connector 23, and the right side surface of the discharge pipe 16 is flush with the left side surface of the sealing plate 19, so that the sealing plate 19 can block the discharge pipe 16 when moving upward.

[0040] During the rotation of the rotating tube 3, the sealing plate 19 and other parts connected to the sealing plate 19 are driven by the rotating tube 3 to rotate synchronously. The following is a description of the working process of the uppermost liquid storage tank 82 and other parts connected thereto as an example: In the process of the exhaust pipe 18 transporting nitrogen into the liquid storage tank 82, the nitrogen entering the liquid storage tank 82 flows along the two liquid inlet pipes 17 to the two transfer pipes 22, and the two transfer pipes 22 guide the nitrogen to the two liquid discharge pipes 16, and finally flows into the liquid storage tank 2 to remove the oxygen contained in the liquid storage tank 2.

[0041] During the process of moving the mounting member 81 upward (the gas delivery device is in the exhaust state at this time), the staff simultaneously starts the second electric push rod 21, and the telescopic end of the second electric push rod 21 drives the sealing plate 19 to move upward synchronously through the second moving ring 20, so that the right-side connector 23 is always connected to the two liquid inlet pipes 17, and at the same time, the left-side connector 23 is squeezed by the inclined surfaces on the two liquid discharge pipes 16 and moves to the right, and the first elastic member 24 on the left is gradually compressed, so that the left-side connector 23 gradually loses contact with the two liquid discharge pipes 16, and the left side of the sealing plate 19 gradually blocks the right port of the liquid discharge pipe 16 to change the flow area of ​​the right port of the liquid discharge pipe 16.

[0042] Until the telescopic end of the second electric push rod 21 is fully extended, the blocking plate 19 stops moving upward, and at the same time, the left pipe connector 23 loses contact with the right ports of the two drainage pipes 16. The left pipe connector 23 gradually returns to the left under the action of the first elastic member 24. At the same time, the right ports of the two drainage pipes 16 are completely blocked by the blocking plate 19 to prevent the residual raw materials in the first sample storage chamber and the second sample storage chamber on the sampler 7 from flowing into the rotating tube 3, causing waste of raw materials. At this time, the right pipe connector 23 is still connected to the two liquid inlet pipes 17, and the two The residual raw material in the transfer tube 22 continues to flow into the two liquid storage chambers 15 due to the suction effect of the gas transmission device, so as to reduce the residual amount of raw material in the two transfer tubes 22 and reduce the waste of raw materials. In the process of the subsequent installation part 81 driving the three liquid storage tanks 82 to continue to move upward, the right-side connector 23 loses contact with the two liquid inlet pipes 17 (the specific process refers to the process of the left-side connector 23 losing contact with the two liquid discharge pipes 16). After taking out the installation part 81, the staff replaced the three liquid storage tanks 82 containing samples.

[0043] After the three liquid storage tanks 82 are replaced, the staff reinstalls the mounting member 81 in the rotating tube 3. The following is a description of the process of the uppermost liquid storage tank 82 moving downward as an example: When the liquid storage tank 82 drives the two liquid inlet pipes 17 thereon to move downward until they contact the right pipe connector 23, the two liquid inlet pipes 17 squeeze the inclined surface on the right pipe connector 23 in the process of continuing to move downward, so that the first elastic member 24 on the right is gradually compressed, and the right pipe connector 23 moves leftward under the squeezing force. When the central axes of the two liquid inlet pipes 17 move downward respectively until they coincide with the central axes of the adjacent transfer pipes 22, the two liquid inlet pipes 17 no longer squeeze the pipe connector 23, and the right pipe connector 23 can be reset to the right under the action of the adjacent first elastic member 24, and the two inclined surfaces on the pipe connector 23 contact the inclined surfaces on the adjacent liquid inlet pipes 17 respectively. The two liquid inlet pipes 17 are connected to the adjacent transfer pipes 22 respectively, and then the staff starts the second electric push rod 21, and the telescopic end of the second electric push rod 21 drives the sealing plate 19 to move downward, and the two liquid discharge pipes 16 are connected to the adjacent transfer pipes 22 respectively (the specific process refers to the connection process between the liquid inlet pipe 17 and the adjacent transfer pipes 22, which will not be described in detail), completing the installation of the mounting part 81, and then the staff controls the gas supply device to continue to transport nitrogen into the two liquid discharge pipes 16, and blows the residual raw materials in the two liquid discharge pipes 16 into the liquid storage tank 2, so as to avoid waste of raw materials and further increase the mixing uniformity of the raw materials in the liquid storage tank 2.

[0044] Embodiment 4: Based on embodiment 3, Figure 2-Figure 8 , Fig.12 and Fig.13 As shown, it also includes: an expansion component, which is arranged between the liquid storage tank 2 and the sealing member 8. The expansion component is used to change the volume of the sample storage chamber on all samplers 7. The expansion component includes: a plurality of sealing plates 25, the number of which is the same as the number of partition plates 13, which are respectively fixed to the side of the adjacent partition plates 13 away from the central axis of the liquid storage tank 2, and the partition plates 13 are provided with liquid storage chambers 26; a plurality of movable plates 27, the number of which is the same as the number of partition plates 13, which are respectively slidably connected to the adjacent liquid storage chambers 26, and the movable plates 27 are fixed to the adjacent sealing plates 25. The sealing plates 25 are made of elastic deformable materials, and the connecting portion between the sealing plates 25 and the adjacent movable plates 27 is located in the middle of the sealing plates 25, and the movable plates 27 are fixed to the adjacent sealing plates 25. A second elastic member 28 is fixedly connected between the movable plate 27 and the adjacent partition plate 13, and the movable plate 27 is sealingly and slidably connected to the adjacent liquid discharge pipe 16; a liquid extraction pipe 29 is fixedly connected in the fixed shell 6, and the liquid extraction pipe 29 is sealingly and slidably connected to the movable plate 27, and the liquid extraction pipe 29 is connected to all liquid storage chambers 26; a liquid storage ring 30 is fixedly connected to the upper side of the first movable ring 10, and the liquid extraction pipe 29 passes through the sealing ring 5, the fixed shell 6 and the first movable ring 10 and is connected to the liquid storage ring 30; a rotating plate 31 is slidably connected to the end cover 4, and the rotating plate 31 rotates in the liquid storage ring 30, and a hydraulic pump is arranged on the end cover 4, and a hose connected to the liquid storage ring 30 is fixedly connected between the hydraulic pump on the end cover 4 and the rotating plate 31.

[0045] In the above scheme, the sealing plate 25 is fixed to the left side of the adjacent partition plate 13; the liquid storage chamber 26 is filled with hydraulic oil; the position of the adjacent movable plate 27 is changed by changing the volume of the hydraulic oil in the liquid storage chamber 26, thereby changing the shape of the adjacent sealing plate 25, so that the sealing plate 25 is deformed and the volume of the cavity on the sampler 7 is increased; the second elastic member 28 is a tension spring, and the second elastic member 28 is initially in a stretched state; hydraulic oil is stored in the liquid storage ring 30.

[0046] During the movement of the first movable ring 10, the first movable ring 10 drives the liquid storage ring 30 to move synchronously. After the position of the sealing member 8 is changed, the staff starts the hydraulic pump on the end cover 4, and the hydraulic pump extracts the hydraulic oil in the liquid storage ring 30 through the hose, and then extracts the hydraulic oil in all the liquid storage chambers 26 through the liquid extraction pipe 29, so that all the movable plates 27 move synchronously to the right (that is, move in the direction close to the central axis of the liquid storage tank 2) under the joint action of the hydraulic oil and the adjacent second elastic member 28, and then stretch the middle part of all the sealing plates 25 to the right, so that all the sealing plates 25 are synchronously stretched and deformed, and finally form a cone, so as to increase the volume of the first sample storage chamber and all the second sample storage chambers on all the samplers 7, and then reduce the pressure in the first sample storage chamber and all the second sample storage chambers on all the samplers 7, so that the gas dissolved in the raw material is easier to form bubbles and expand rapidly, thereby accelerating the rising speed of the bubbles, thereby reducing the gas content in the sample taken, preventing the bubbles from affecting the test results of the samples, and further increasing the accuracy of the sample test results.

[0047] After the sampling is completed, the staff controls the hydraulic pump to return the extracted hydraulic oil to all the liquid storage chambers 26, so that all the sealing plates 25 are restored to their initial states for subsequent continued use.

[0048] The above description is only an example of the present invention and is not intended to limit the present invention. Any equivalent substitutions made within the principles of the present invention should be included in the protection scope of the present invention. The contents not elaborated in detail in the present invention belong to the existing technologies known to those skilled in the art.

Claims

1. A L-carnitine injection, characterized in that: Including the following raw materials: 18%-22% of L-carnitine by mass, 5%-10% of vitamin antioxidant by mass, 28%-33% of Chinese herbal extract by mass, pH regulator and water for injection to make up the rest; the Chinese herbal extract includes the following raw materials: 10% by weight of ginseng extract, 10% by weight of wolfberry extract, 20% by weight of astragalus extract, 10% by weight of salvia miltiorrhiza extract, 8% by weight of schisandra chinensis extract, 14% by weight of panax notoginseng extract and the balance made up of pure water.

2. A device for preparing L-carnitine injection, according to the L-carnitine injection according to claim 1, characterized in that: include: A bracket (1), the bracket (1) being fixedly connected to a liquid storage tank (2), the liquid storage tank (2) being equipped with a connecting piece; A rotating tube (3) is sealingly and rotatably connected to the liquid storage tank (2), and a driving module is provided between the liquid storage tank (2) and the rotating tube (3); An end cover (4) is mounted on a connecting piece of the liquid storage tank (2), and the rotating tube (3) passes through the end cover (4) and is rotatably connected thereto; A sealing ring (5) is rotatably connected to the end cover (4), and the sealing ring (5) is rotatably connected to the liquid storage tank (2); A fixed shell (6) is fixedly connected to the sealing ring (5), and the fixed shell (6) is slidably connected to the liquid storage tank (2); A plurality of samplers (7) are provided on the rotating tube (3); the samplers (7) are rotationally connected to a sealing member (8); and the sealing member (8) is rotationally connected to the fixed shell (6); A mounting member (81) is detachably connected to the interior of the rotating tube (3); the mounting member (81) is detachably connected to a plurality of liquid storage tanks (82); the number of the liquid storage tanks (82) is the same as the number of the samplers (7); and the liquid storage tanks (82) are in communication with adjacent samplers (7); A trigger assembly is arranged on the liquid storage tank (2), and the trigger assembly is used to change the position of all the sealing components (8).

3. A device for preparing L-carnitine injection according to claim 2, characterized in that: The sampler (7) and the seal (8) are both composed of a circular plate portion and symmetrically distributed arc portions, the central angle corresponding to the arc portion on the sampler (7) is equal to 90°, and the central angle corresponding to the arc portion on the seal (8) is greater than 90°. When the seal (8) rotates 90°, the seal (8) and the adjacent sampler (7) jointly form a cavity.

4. A device for preparing L-carnitine injection according to claim 3, characterized in that: The trigger component comprises: A first electric push rod (9) is installed on the outside of the liquid storage tank (2); A first movable ring (10) is slidably connected to the sealing ring (5), and the first movable ring (10) is slidably connected to the telescopic end of the first electric push rod (9); A drive rod (11) is fixedly connected to a side of the first movable ring (10) close to the fixed shell (6), and the drive rod (11) slides in the fixed shell (6). The sealing member (8) is fixedly connected to a drive gear (12) located in the fixed shell (6), and a rack meshing with the drive gear (12) is installed on the drive rod (11).

5. A device for preparing L-carnitine injection according to claim 4, characterized in that: Also includes: A plurality of partition assemblies, the number of which is the same as the number of the sealing members (8), the partition assemblies being used to separate the samples taken, the partition assemblies being arranged between the sampler (7) and the rotating tube (3), and the partition assemblies comprising: A plurality of partition plates (13) are fixedly connected to adjacent samplers (7); the partition plates (13) close to the central axis of the liquid storage tank (2) pass through the rotating tube (3) and are rotatably connected thereto; the sealing member (8) is slidably connected to the partition plates (13); the plurality of partition plates (13) divide the cavity formed by the sampler (7) and the sealing member (8) into a plurality of sample storage cavities; and the liquid storage tank (82) is provided with liquid storage cavities (15) of the same number as the number of the partition plates (13); a plurality of liquid discharge pipes (16), the number of which is the same as the number of the partition plates (13), and all of which are fixedly connected to the sampler (7), the liquid discharge pipes (16) being in communication with adjacent sample storage cavities on the sampler (7); A plurality of liquid inlet pipes (17), the number of which is the same as the number of the partition plates (13), are fixedly connected to the liquid storage tank (82), the liquid inlet pipes (17) are connected to the adjacent liquid discharge pipes (16), and the plurality of liquid inlet pipes (17) are respectively connected to the plurality of liquid storage chambers (15).

6. A device for preparing L-carnitine injection according to claim 5, characterized in that: The sampler (7) is provided with a plurality of conical surfaces, the specific number of which is the same as the specific number of the partition plates (13) thereon, for guiding the flow of the sample in the sampler (7).

7. A device for preparing L-carnitine injection according to claim 6, characterized in that: Also includes: An exhaust pipe (18) is installed in the rotating tube (3). The exhaust pipe (18) is provided with a plurality of branch pipes. The number of the branch pipes on the exhaust pipe (18) is the same as the number of the liquid storage tanks (82). The branch pipes on the exhaust pipe (18) are fixedly connected to the adjacent liquid storage tanks (82), and the branch pipes on the exhaust pipe (18) are communicated with all the liquid storage chambers (15) on the adjacent liquid storage tanks (82).

8. A device for preparing L-carnitine injection according to claim 7, characterized in that: Also includes: A plugging component is arranged between the sampler (7) and the rotating tube (3), the plugging component is used to change the flow relationship of all the drainage tubes (16), and the plugging component comprises: A blocking plate (19) is slidably connected to the rotating tube (3), and the blocking plate (19) is used to change the flow relationship of all the drainage tubes (16); A second movable ring (20) slidably connected to the blocking plate (19); A second electric push rod (21) is fixedly connected to the end cover (4), and a telescopic end of the second electric push rod (21) is fixedly connected to the second movable ring (20), and the blocking plate (19) is provided with storage cavities having the same number as the samplers (7); A plurality of transfer tubes (22), the number of which is the same as the number of the liquid discharge tubes (16), are respectively fixedly connected to adjacent storage cavities on the blocking plate (19); two symmetrically distributed pipe connectors (23) are slidably connected to the storage cavity of the blocking plate (19); the pipe connectors (23) are slidably connected to the transfer tubes (22); the two pipe connectors (23) and adjacent transfer tubes (22) jointly connect the liquid discharge tube (16) with the adjacent liquid inlet tube (17); and a first elastic member (24) is fixedly connected between the pipe connector (23) and the blocking plate (19).

9. A device for preparing L-carnitine injection according to claim 8, characterized in that: Also includes: An expansion component is arranged between the liquid storage tank (2) and the sealing member (8), and is used to change the volume of the sample storage chamber on all the samplers (7). The expansion component comprises: A plurality of sealing plates (25), the number of which is the same as the number of the partition plates (13), respectively fixed to a side of the adjacent partition plates (13) away from the central axis of the liquid storage tank (2), and the partition plates (13) are provided with liquid storage cavities (26); A plurality of movable plates (27), the number of which is the same as the number of the partition plates (13), which are respectively slidably connected to adjacent liquid storage chambers (26); the movable plates (27) are fixedly connected to adjacent sealing plates (25); a second elastic member (28) is fixedly connected between the movable plates (27) and the adjacent partition plates (13); and the movable plates (27) are sealed and slidably connected to adjacent liquid discharge pipes (16); The liquid extraction tube (29) is fixedly connected in the fixed shell (6), and the liquid extraction tube (29) is sealingly and slidably connected to the movable plate (27), and the liquid extraction tube (29) is in communication with all the liquid storage chambers (26).

10. A device for preparing L-carnitine injection according to claim 9, characterized in that: The expansion component also includes: A liquid storage ring (30) is fixedly connected to the upper side of the first movable ring (10); the liquid extraction pipe (29) passes through the sealing ring (5), the fixed shell (6) and the first movable ring (10) to communicate with the liquid storage ring (30); A rotating plate (31) is slidably connected to the end cover (4); the rotating plate (31) rotates in the liquid storage ring (30); a hydraulic pump is provided on the end cover (4); a hose communicating with the liquid storage ring (30) is fixedly connected between the hydraulic pump on the end cover (4) and the rotating plate (31).

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