Method for simulating deep brain stimulation operation based on virtual simulation technology

Abstract

The invention discloses a method for simulating a deep brain stimulation operation based on a virtual simulation technology, which belongs to the technical field of analogue simulation learning and comprises a data acquisition unit, a registration reconstruction model unit and a simulation puncture simulation unit. According to the method, three-dimensional reconstruction of a visual model of a basal ganglion-related anatomical structure is carried out through software such as 3D Slicer and Matlab, and a virtual simulation puncture technology is utilized to simulate a deep brain stimulation operation electrode implantation process, so that the learning time is shortened, the learning interest is improved, and the learning effect is improved; through the virtual simulation electrode implantation process, the position and the adjacent structure of the simulation electrode can be dynamically displayed in a multi-plane mode in real time, target nucleus virtual simulation electrode implantation is carried out on the basis of a basal ganglion model, the optimal puncture path is determined through the designed puncture target and puncture point, and the target nucleus virtual simulation electrode implantation operation is carried out on the basis of the basal ganglion model. Therefore, the process of deep brain electrical stimulation electrode implantation is displayed, the position of each nuclei and the adjacent nuclei can be observed from a three-dimensional angle, and the understanding and understanding of related loops are deepened.

Description

Technical Field

[0001] The present invention relates to the field of simulation learning technology, and in particular to a method for simulating deep brain electrical stimulation surgery based on virtual simulation technology. Background Art

[0002] Deep brain stimulation (DBS) has the advantages of being controllable, reversible, and non-damaging to brain tissue. It can significantly improve the symptoms of patients with Parkinson's disease, essential tremor, torsion spasm, and other dystonia diseases, and improve their quality of life. It has gradually replaced destructive surgery and is currently the main surgical treatment method in clinical practice. The selection of targets and the precise implantation of electrodes are the key to ensuring the efficacy of surgery. In the past, the study of the anatomical structure related to the basal ganglia mainly relied on atlases and gross specimens. There was little research on the anatomical structure related to the basal ganglia, and the anatomical structure was complex. Young doctors were unable to effectively combine the anatomical structure with function and clinical practice. Some targets are invisible to imaging. Young functional neurosurgeons often have low interest in learning, which reduces their learning effect. Based on this, a method for simulating deep brain stimulation surgery based on virtual simulation technology is proposed. It uses 3D Slicer, Matlab and other software to reconstruct the three-dimensional visualization model of the anatomical structure related to the basal ganglia, and uses virtual simulation puncture technology to simulate the electrode implantation process of deep brain stimulation surgery, aiming to shorten the learning time, enhance learning interest and improve learning effect. Summary of the invention

[0003] The purpose of the present invention is to solve the problems in the prior art that the study of basal ganglia related anatomical structures mainly relies on atlases and gross specimens, there is little research on basal ganglia related anatomical structures, the anatomical structures are complex, and young doctors are unable to effectively combine the anatomical structures with functions and clinical practice. A method for simulating deep brain stimulation surgery based on virtual simulation technology is proposed, which uses 3D Slicer, Matlab and other software to perform three-dimensional reconstruction of the visualization model of the basal ganglia related anatomical structures, and uses virtual simulation puncture technology to simulate the deep brain stimulation surgery electrode implantation process, aiming to shorten the learning time, enhance learning interest, and thus improve learning effects.

[0004] In order to achieve the above object, the present invention adopts the following technical solutions:

[0005] The method for simulating deep brain electrical stimulation surgery based on virtual simulation technology includes a data acquisition unit, a registration reconstruction model unit and a simulation puncture simulation unit, and specifically includes the following steps:

[0006] S1. Data collection: Brain data collection is achieved through cranial MRI technology and CT imaging;

[0007] S2. Data registration: Use 3D Slicer software technology to register brain data and obtain the latest registration data;

[0008] S3, 3D reconstruction: Based on the latest registration data, 3D Slicer software and Matlab software technology are used to process the data and perform the following reconstructions in sequence:

[0009] Reconstruct the artery model through the registered MRA / CTA data;

[0010] Reconstruct the vein model through the registered MRV / CTV data;

[0011] The skull model is reconstructed through the registered CT data;

[0012] The target model is reconstructed through the registered T2WI and SWI data;

[0013] The gray matter model, white matter model and ventricular system model were reconstructed by segmenting the registered structural image data using the Matlab software CAT12 plug-in.

[0014] S4. Model combination adjustment: Use the Model module to display various models, and adjust the transparency and color of each model for distinction;

[0015] S5. Simulation of puncture: Use the Lead OR module to reconstruct the virtual puncture needle, and use the Transform module to perform a virtual demonstration of the puncture path.

[0016] Preferably, the target model in S3 includes the globus pallidus internalis and the subthalamic nucleus.

[0017] Preferably, in S5, based on the model, a Stereotactic Plan module is used to reconstruct a virtual electrode, and a Transform module is used to perform a virtual simulation of electrode puncture, so as to display the electrode implantation process in real time, and the optimal puncture path can be determined by flexible adjustment according to the surgical purpose and the path structure.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] 1. The present invention utilizes 3D Slicer, Matlab and other software to perform three-dimensional reconstruction of the visualization model of the anatomical structure related to the basal ganglia, and utilizes virtual simulation puncture technology to simulate the electrode implantation process of deep brain electrical stimulation surgery, aiming to shorten the learning time, enhance learning interest, and thus improve learning effect.

[0020] 2. The virtual simulation electrode implantation process proposed in the present invention can dynamically display the position and adjacent structures of the simulated electrode in real time and in multiple planes. It can perform virtual simulation electrode implantation of target nuclei based on the basal ganglia model, determine the optimal puncture path through the designed puncture targets and puncture points, and then demonstrate the process of deep brain electrical stimulation electrode implantation.

[0021] 3. The present invention uses the model and related videos to study basal ganglia-related diseases, which helps to observe the location of each nucleus and its adjacent areas from a three-dimensional perspective, deepen the understanding and knowledge of related circuits, increase learning interest, and improve learning effects. It is worthy of further promotion and application in clinical practice teaching. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 A flowchart of a method for simulating deep brain electrical stimulation surgery based on virtual simulation technology proposed by the present invention;

[0023] Figure 2 A schematic diagram of the process framework of the method for simulating deep brain electrical stimulation surgery based on virtual simulation technology proposed by the present invention;

[0024] Figure 3 The method for simulating deep brain electrical stimulation surgery based on virtual simulation technology proposed by the present invention is simulated Figure 1 ;

[0025] Figure 4 The method for simulating deep brain electrical stimulation surgery based on virtual simulation technology proposed by the present invention is simulated Figure 2 ;

[0026] Figure 5 The method for simulating deep brain electrical stimulation surgery based on virtual simulation technology proposed by the present invention is simulated Figure 3 . DETAILED DESCRIPTION

[0027] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0028] Example, see Figures 1 to 5 A method for simulating deep brain electrical stimulation surgery based on virtual simulation technology includes a data acquisition unit, a registration reconstruction model unit and a simulation puncture simulation unit, and specifically includes the following steps:

[0029] The brain data is collected through cranial MRI technology and CT imaging;

[0030] Use 3D Slicer software technology to register brain data and obtain the latest registration data;

[0031] The open source software 3D Slicer was used for data processing and virtual simulation puncture. First, the registration module was used to process multimodal imaging data, aiming to make all anatomical structures located in the same spatial coordinate system.

[0032] Based on the latest registration data, 3D Slicer software and Matlab software technology were used for data processing, and the following reconstructions were performed in sequence: the artery model was reconstructed through the registered MRA / CTA data; the vein model was reconstructed through the registered MRV / CTV data; the skull model was reconstructed through the registered CT data; the target model was reconstructed through the registered T2WI and SWI data; the gray matter model, white matter model and ventricular system model were reconstructed through the segmentation of the registered structural image data using the Matlab software CAT12 plug-in;

[0033] Use the Model module combination to display each model, and adjust the transparency and color of each model for distinction;

[0034] Among them, the above-mentioned multiple modules and multiple methods were used to reconstruct the skin, frontal bone, most of the lateral ventricles on both sides, caudate nucleus, putamen, globus pallidus lateralis, globus pallidus medialis, subthalamic nucleus, red nucleus, gray matter and white matter models in sequence, the color and transparency were adjusted to observe the position of the nerve nuclei, and the relevant anatomy of the basal ganglia was reviewed in combination with two-dimensional images.

[0035] The Lead OR module is used to reconstruct the virtual puncture needle, and the Transform module is used to perform a virtual demonstration of the puncture path. Based on the model, the Stereotactic Plan module is used to reconstruct the virtual electrode, and the Transform module is used to perform a virtual simulation of the electrode puncture, and the electrode implantation process is displayed in real time. It can be flexibly adjusted according to the surgical purpose and the path structure to determine the optimal puncture path.

[0036] Based on the above, you can record the puncture process according to actual needs, use the corresponding software to make it into a video, upload it to the corresponding website, and share it for learning.

[0037] The present invention uses 3D Slicer, Matlab and other software to perform three-dimensional reconstruction of the visualization model of the anatomical structure related to the basal ganglia, and uses virtual simulation puncture technology to simulate the deep brain electrical stimulation surgical electrode implantation process, aiming to shorten the learning time, enhance learning interest, and thus improve learning effect; the virtual simulation electrode implantation process proposed in this study can display the position and adjacent structures of the simulated electrode in real time and in multiple planes and dynamically, and perform virtual simulation electrode implantation of the target nucleus on the basis of the basal ganglia model, and determine the best puncture path through the designed puncture target and puncture point, and then show the process of deep brain electrical stimulation electrode implantation. At the same time, using this model and related videos to study basal ganglia related diseases is helpful to observe the position and adjacent of each nucleus from a three-dimensional perspective, deepen the understanding and recognition of related circuits, increase learning interest, and improve learning effect, which is worthy of further promotion and application in clinical practice teaching.

[0038] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A method for simulating deep brain electrical stimulation surgery based on virtual simulation technology, characterized in that: It includes a data acquisition unit, a registration and reconstruction model unit and a simulation puncture simulation unit, and specifically includes the following steps: S1. Data collection: Brain data collection is achieved through cranial MRI technology and CT imaging; S2. Data registration: Use 3D Slicer software technology to register brain data and obtain the latest registration data; S3, 3D reconstruction: Based on the latest registration data, 3D Slicer software and Matlab software technology are used to process the data and perform the following reconstructions in sequence: Reconstruct the artery model through the registered MRA / CTA data; Reconstruct the vein model through the registered MRV / CTV data; The skull model is reconstructed through the registered CT data; The target model is reconstructed through the registered T2WI and SWI data; The gray matter model, white matter model and ventricular system model were reconstructed by segmenting the registered structural image data using the Matlab software CAT12 plug-in. S4. Model combination adjustment: Use the Model module to display various models, and adjust the transparency and color of each model for distinction; S5. Simulation of puncture: Use the Lead OR module to reconstruct the virtual puncture needle, and use the Transform module to perform a virtual demonstration of the puncture path.

2. The method for simulating deep brain electrical stimulation surgery based on virtual simulation technology according to claim 1, characterized in that: The target model in S3 includes the globus pallidus internalis and the subthalamic nucleus.

3. The method for simulating deep brain electrical stimulation surgery based on virtual simulation technology according to claim 1, characterized in that: In the S5, based on the model, the Stereotactic Plan module is used to reconstruct the virtual electrode, and the Transform module is used to perform the electrode virtual simulation puncture simulation, and the electrode implantation process is displayed in real time. It can be flexibly adjusted according to the surgical purpose and the path structure to determine the optimal puncture path.

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