A method, device and program product for evaluating pulmonary circulation time based on contrast agent enhanced EIT

Abstract

The present application relates to the field of intelligent medical care, and specifically to a method, device, and program product for evaluating pulmonary circulation time based on contrast agent-enhanced EIT. The method comprises S1, obtaining contrast agent-enhanced pulmonary EIT data of a test subject; S2, determining the pulmonary circulation start time and pulmonary perfusion end time based on the contrast agent-enhanced pulmonary EIT data; the pulmonary circulation start time is the moment when the electrical impedance signal of the contrast agent injected changes while the test subject holds his breath, and the pulmonary perfusion end time is the moment when the electrical impedance signal does not change after the contrast agent is injected while the test subject holds his breath; S3, subtracting the pulmonary circulation start time from the pulmonary perfusion end time to obtain the pulmonary circulation time. The pulmonary circulation time evaluation method of the present application can realize bedside detection, is easy to operate, and has great clinical application value.

Description

Technical Field

[0001] The present application relates to the field of intelligent medical care, and specifically to a method, device, program product, and computer-readable storage medium for evaluating pulmonary circulation time based on contrast agent-enhanced EIT. Background Art

[0002] Pulmonary transit time (PTT) refers to the time it takes for blood to travel from the right ventricle of the heart through the pulmonary artery to the pulmonary capillary network, and then from there back to the left atrium via the pulmonary veins. PTT primarily assesses the functional status of the cardiopulmonary vascular system, particularly the hemodynamic characteristics of the pulmonary circulation, such as pulmonary vascular resistance, blood flow velocity, and right heart function. It is crucial for the diagnosis and monitoring of pulmonary vascular diseases such as pulmonary embolism and pulmonary hypertension. In pulmonary embolism, a blood clot blocks the pulmonary artery or its branches, obstructing blood flow to the affected area. Consequently, blood takes longer to transit the obstructed pulmonary vascular bed, resulting in a prolonged PTT. In pulmonary hypertension, increased pulmonary vascular resistance and elevated pulmonary artery pressure slow blood transit through the pulmonary vascular bed, leading to a prolonged PTT. Currently, the main clinical methods for assessing PTT include radionuclide scanning, CT perfusion imaging, magnetic resonance imaging (MRI), and echocardiography. Radionuclide scanning uses radiotracers to provide reliable regional information but involves radiation exposure. CT perfusion imaging offers high spatial resolution and can simultaneously obtain anatomical and functional information, but also presents radiation issues. MRI is radiation-free and reproducible, but the examination time is long and not suitable for bedside use. Echocardiography is noninvasive and portable, but is operator-dependent and requires high clinical resources. Therefore, a PTT calculation method suitable for bedside use, radiation-free, and simple to perform is needed.

[0003] Furthermore, pulmonary regional perfusion time (PRPT), which measures the residence time of blood in a specific region of the lung, is a complex medical imaging and analysis issue. Uneven distribution of pulmonary blood flow can lead to insufficient oxygen exchange in certain areas, impacting overall respiratory function. In clinical practice, assessing PRPT aids in the diagnosis and monitoring of pulmonary hemodynamic abnormalities, such as pulmonary embolism, pulmonary vascular disease, and chronic obstructive pulmonary disease (COPD). Traditional methods, such as pulmonary ventilation / perfusion scans or CT scans, can provide information but may be imprecise or difficult to monitor in real time. With the advancement of medical imaging technologies, particularly computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET), the assessment of pulmonary perfusion has become more sophisticated, but remaining technical challenges primarily include how to accurately and in real time measure and analyze blood flow in various regions of the lung, and how to reduce errors and improve image quality across various imaging techniques. Summary of the Invention

[0004] To address the above problems, the present invention provides a method for evaluating pulmonary circulation time based on contrast agent-enhanced EIT, which specifically includes:

[0005] S1. Obtaining contrast-enhanced lung EIT data of the test subject;

[0006] S2. Determine a pulmonary circulation start time and a pulmonary perfusion end time based on the contrast agent-enhanced pulmonary EIT data; the pulmonary circulation start time is the moment when the electrical impedance signal of the contrast agent injected changes while the subject holds his breath, and the pulmonary perfusion end time is the moment when the electrical impedance signal does not change after the contrast agent is injected while the subject holds his breath;

[0007] S3. Subtract the pulmonary circulation start time from the pulmonary perfusion end time to obtain the pulmonary circulation time.

[0008] Furthermore, the time when the change occurs is the time when the impedance curve decreases and the slope of the impedance curve is negative during breath holding, with the average value of the end-of-breath impedance of N times before breath holding as the baseline, and N is a natural number greater than 1;

[0009] Optionally, the impedance curve decreases by 5%-10% during breath holding;

[0010] Optionally, the average of the end-of-breath impedances for 3-5 breaths before breath-holding is used as the baseline;

[0011] Optionally, the moment when no change occurs is a moment when the slope of the impedance curve is positive and the value is less than 0.01.

[0012] The method further includes evaluating the regional circulation time of the left and right lungs, and performing the left lung regional circulation time evaluation or the right lung regional circulation time evaluation based on the EIT data change of the contrast agent in the left lung or the right lung;

[0013] Optionally, the left lung regional circulation time is obtained by determining the left lung circulation start time and the left lung circulation end time from the left lung EIT data, and then subtracting the left lung circulation start time from the left lung circulation end time;

[0014] Optionally, the left lung circulation start time is the moment when the slope of the left lung impedance curve is negative during breath holding, and the left lung circulation end time is the moment when the slope of the left lung impedance curve is positive during breath holding;

[0015] Optionally, the right lung regional circulation time is obtained by determining the right lung circulation start time and the right lung circulation end time in the right lung EIT data, and then subtracting the right lung circulation start time from the right lung circulation end time.

[0016] Optionally, the right pulmonary circulation start time is the moment when the slope of the right pulmonary impedance curve is negative during breath holding, and the right pulmonary circulation end time is the moment when the slope of the right pulmonary impedance curve is positive during breath holding.

[0017] The method further includes evaluating the regional circulation time of the anterior and posterior lungs, and evaluating the regional circulation time of the anterior lungs or the regional circulation time of the posterior lungs according to the EIT data changes of the contrast agent in the anterior lungs or the posterior lungs.

[0018] Optionally, the front lung region circulation time is obtained by determining the front lung circulation start time and the front lung circulation end time from the front lung EIT data, and then subtracting the front lung circulation start time from the front lung circulation end time.

[0019] Optionally, the start time of the front pulmonary circulation is the moment when the slope of the front pulmonary impedance curve is negative during breath holding, and the end time of the front pulmonary circulation is the moment when the slope of the front pulmonary impedance curve is positive during breath holding.

[0020] Optionally, the posterior lung regional circulation time is obtained by determining the posterior pulmonary circulation start time and the posterior pulmonary circulation end time in the posterior lung EIT data, and then subtracting the posterior pulmonary circulation start time from the posterior pulmonary circulation end time.

[0021] Optionally, the posterior pulmonary circulation start time is the moment when the slope of the posterior pulmonary impedance curve is negative during breath holding, and the posterior pulmonary circulation end time is the moment when the slope of the posterior pulmonary impedance curve is positive during breath holding.

[0022] The object of the present invention is to provide a computer program product having a computer program or instructions thereon, comprising: the computer program or instructions are executed by a processor to implement the above-mentioned method for evaluating pulmonary circulation time based on contrast agent enhanced EIT.

[0023] The object of the present invention is to provide a computer device for evaluating pulmonary circulation time based on contrast agent enhanced EIT, comprising a memory and a processor and a computer program or instructions stored on the memory, wherein the computer program or instructions are executed by the processor to implement the above-mentioned method for evaluating pulmonary circulation time based on contrast agent enhanced EIT.

[0024] The object of the present invention is to provide a computer-readable storage medium having a computer program or instructions stored thereon, including: the computer program or instructions are executed by a processor to implement the above-mentioned method for evaluating pulmonary circulation time based on contrast agent enhanced EIT.

[0025] The present invention proposes an imaging method for lung regional perfusion time image, which specifically includes:

[0026] Obtain pulmonary circulation time and lung regional location information;

[0027] Functional image reconstruction is performed based on the lung circulation time and lung region position information to obtain a lung region perfusion time image.

[0028] The functional image reconstruction utilizes a reconstruction algorithm to perform data reconstruction.

[0029] Optionally, the pulmonary circulation time is obtained by one or more of the following methods: obtaining the pulmonary circulation time through nuclear scanning, obtaining the pulmonary circulation time through CT perfusion imaging, obtaining the pulmonary circulation time through magnetic resonance imaging, and obtaining the pulmonary circulation time through echocardiography.

[0030] Optionally, the method for acquiring the lung region position information includes:

[0031] Acquire lung imaging data;

[0032] Lung region position information is obtained by extracting position information based on the lung image data.

[0033] Optionally, the image data includes one or more of the following: nuclear scanning images, CT perfusion images, magnetic resonance images, and ultrasound images.

[0034] Optionally, the lung medical image data also includes EIT images.

[0035] Optionally, the pulmonary circulation time is obtained by the above-mentioned method for evaluating pulmonary circulation time based on contrast agent-enhanced EIT;

[0036] Optionally, the lung region position information is obtained by using EIT data in the above-mentioned method for evaluating pulmonary circulation time based on contrast agent enhanced EIT.

[0037] The object of the present invention is to provide a computer program product having a computer program or instructions thereon, comprising: the computer program or instructions being executed by a processor to implement the above-mentioned imaging method of lung regional perfusion time image.

[0038] An object of the present invention is to provide an imaging device for regional lung perfusion time images, comprising a memory and a processor and a computer program or instructions stored in the memory, wherein the computer program or instructions are executed by the processor to implement the above-mentioned imaging method for regional lung perfusion time images.

[0039] The object of the present invention is to provide a computer-readable storage medium having a computer program or instruction stored thereon, including: the computer program or instruction is executed by a processor to implement the above-mentioned imaging method of lung regional perfusion time image.

[0040] The present invention aims to provide a method for evaluating regional perfusion time based on a lung regional perfusion time image, comprising:

[0041] Obtaining a lung regional perfusion time image according to the above-mentioned lung regional perfusion time image imaging method;

[0042] selecting a lung region based on the lung region perfusion time image;

[0043] The number of pixels in the lung region and the pixel values ​​are calculated to obtain the time when perfusion occurs in the lung region.

[0044] Optionally, the lung region is a region of any size;

[0045] Optionally, the lung region includes one or more of the following: the entire lung region, the left lung region, the right lung region, the front lung region, and the back lung region.

[0046] The object of the present invention is to provide a computer program product having a computer program or instructions thereon, comprising: the computer program or instructions being executed by a processor to implement the above-mentioned regional perfusion time assessment method based on lung regional perfusion time image.

[0047] The object of the present invention is to provide a regional perfusion time assessment device based on a lung regional perfusion time image, comprising a memory and a processor and a computer program or instructions stored on the memory, wherein the computer program or instructions are executed by the processor to implement the above-mentioned regional perfusion time assessment method based on a lung regional perfusion time image.

[0048] The object of the present invention is to provide a computer-readable storage medium having a computer program or instructions stored thereon, including: the computer program or instructions are executed by a processor to implement the above-mentioned regional perfusion time assessment method based on lung regional perfusion time image.

[0049] Advantages of the present invention:

[0050] 1. A pulmonary circulation time assessment process based on contrast-enhanced EIT is proposed. Compared with traditional pulmonary circulation assessment methods, it is radiation-free, low-cost, portable, and can be performed at the bedside and for frequent monitoring, facilitating real-time observation of lung diseases.

[0051] 2. The pulmonary circulation time of the present invention can not only evaluate the overall pulmonary circulation time (PTT), but also analyze the pulmonary circulation time of the left and right lungs based on clinical conditions (such as unilateral pulmonary embolism). In addition, it can obtain the pulmonary circulation time of the anterior lung and the posterior lung, and the circulation time of any lung area as needed. This helps to accurately detect the onset area of ​​pulmonary disease, improve the diagnosis of targeted problem areas, and provide a potential new means for the diagnosis and monitoring of pulmonary circulation diseases.

[0052] 3. A lung regional perfusion time imaging method is proposed. A new functional map is obtained by image reconstruction based on the lung regional position information and lung circulation time. Each pixel represents the time required for blood or contrast agent to reach different areas. A lung regional perfusion time functional map is constructed, which is beneficial for subsequent lung disease monitoring and diagnosis.

[0053] 4. The functional image of lung regional perfusion time imaging can intuitively observe the length of time of lung regional perfusion in the test subject, which helps doctors understand the condition of the test subject's lungs and shorten the diagnosis time. BRIEF DESCRIPTION OF THE DRAWINGS

[0054] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative work.

[0055] Figure 1 A flow chart of a method for evaluating pulmonary circulation time based on contrast-enhanced EIT provided in an embodiment of the present invention;

[0056] Figure 2 A schematic diagram of a system for evaluating pulmonary circulation time based on contrast-enhanced EIT provided in an embodiment of the present invention;

[0057] Figure 3 A schematic diagram of a device for assessing pulmonary circulation time based on contrast-enhanced EIT provided in an embodiment of the present invention;

[0058] Figure 4 A schematic diagram of determining the circulation time of the entire lung region provided by an embodiment of the present invention;

[0059] Figure 5 A schematic diagram of determining the circulation time of the left and right lungs according to an embodiment of the present invention;

[0060] Figure 6 A schematic diagram of determining the circulation time of the front and back lungs according to an embodiment of the present invention;

[0061] Figure 7 A schematic flow chart of a method for imaging a lung regional perfusion time image provided by an embodiment of the present invention;

[0062] Figure 8 Schematic diagram of an imaging system for lung regional perfusion time images according to an embodiment of the present invention;

[0063] Figure 9A schematic diagram of an imaging device for a lung regional perfusion time image provided by an embodiment of the present invention;

[0064] Figure 10 A schematic diagram of a lung regional perfusion time image provided by an embodiment of the present invention. DETAILED DESCRIPTION

[0065] In order to enable those skilled in the art to better understand the solutions of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention.

[0066] In some of the processes described in the specification and claims of the present invention and the above-mentioned figures, multiple operations that appear in a specific order are included, but it should be clearly understood that these operations may not be executed in the order in which they appear in this article or may be executed in parallel. The serial numbers of the operations, such as S101, S102, etc., are only used to distinguish between different operations, and the serial numbers themselves do not represent any execution order. In addition, these processes may include more or fewer operations, and these operations may be executed in sequence or in parallel. It should be noted that the descriptions of "first", "second", etc. in this article are used to distinguish different messages, devices, modules, etc., and do not represent the order of precedence, nor do they limit "first" and "second" to be different types.

[0067] Figure 1 A schematic diagram of a method for evaluating pulmonary circulation time based on contrast agent-enhanced EIT provided in an embodiment of the present invention specifically includes:

[0068] S1: Obtain the EIT data of the test subject's lungs enhanced by contrast agent;

[0069] In one embodiment, the EIT data includes one or more of the following: an EIT image, and an EIT impedance change curve.

[0070] In one embodiment, the process of collecting contrast-enhanced lung EIT data for a subject is as follows:

[0071] First, patients were required to undergo a breath-hold test. Mechanically ventilated patients were required to adjust to fully controlled ventilation mode and hold their breath for at least 10 seconds, while spontaneously breathing patients were required to hold their breath for at least 10 seconds. Second, the patients were connected to a pulmonary impedance monitoring instrument, and 10 ml of 10% NaCl solution was prepared, and a central venous catheter was confirmed to have been established. Subsequently, while initiating breath-hold, saline was rapidly injected through the central venous catheter, and chest impedance signals were continuously collected starting 2 minutes before the injection, with the entire process recorded for at least 5 minutes to capture the complete pulmonary circulation impedance change process.

[0072] S2: Determining a pulmonary circulation start time and a pulmonary perfusion end time based on the contrast agent-enhanced pulmonary EIT data; the pulmonary circulation start time is the moment when the electrical impedance signal of the contrast agent injected changes while the subject holds his breath, and the pulmonary perfusion end time is the moment when the electrical impedance signal does not change after the contrast agent is injected while the subject holds his breath;

[0073] In one embodiment, the time when the change occurs is the time when the impedance curve decreases and the slope of the impedance curve is negative during breath holding, with the average value of the N end-of-breath impedances before breath holding as the baseline, and N is a natural number greater than 1.

[0074] In one embodiment, the impedance curve decreases by 5%-10% during breath-holding.

[0075] In one embodiment, the average value of the end-of-breath impedance of 3-5 breaths before breath-holding is used as the baseline.

[0076] In one embodiment, the moment when no change occurs is the moment when the slope of the impedance curve is positive and the value is less than 0.01.

[0077] In a specific embodiment, according to the changes of contrast agent in EIT whole lung image, such as Figure 4 As shown, the starting time of the pulmonary circulation is marked on the overall impedance curve: the average impedance of the three end-expirations before breath holding is used as the baseline, and the time point when the impedance curve begins to drop by 5% during the breath holding phase and the slope of the curve is negative is The time point when the slope of the impedance curve is positive and the value is less than 0.01 is defined as the end of perfusion, that is, .

[0078] S3: Subtract the pulmonary circulation start time from the pulmonary perfusion end time to obtain the pulmonary circulation time.

[0079] In a specific embodiment, upon obtaining and , subtract to get the overall pulmonary circulation time .

[0080] In one embodiment, the method further includes evaluating the regional circulation time of the left and right lungs, and performing the left lung regional circulation time evaluation or the right lung regional circulation time evaluation based on the EIT data change of the contrast agent in the left lung or the right lung.

[0081] In one embodiment, the left lung regional circulation time is obtained by determining the left lung circulation start time and the left lung circulation end time from the left lung EIT data, and then subtracting the left lung circulation start time from the left lung circulation end time.

[0082] In one embodiment, the left lung circulation start time is the moment when the slope of the left lung impedance curve is negative during breath holding, and the left lung circulation end time is the moment when the slope of the left lung impedance curve is positive during breath holding.

[0083] In one embodiment, the right lung regional circulation time is obtained by determining the right lung circulation start time and the right lung circulation end time from the right lung EIT data, and then subtracting the right lung circulation start time from the right lung circulation end time.

[0084] In one embodiment, the right pulmonary circulation start time is the moment when the slope of the right pulmonary impedance curve is negative during breath holding, and the right pulmonary circulation end time is the moment when the slope of the right pulmonary impedance curve is positive during breath holding.

[0085] In one embodiment, the method further includes evaluating the regional circulation time of the anterior and posterior lungs, and evaluating the regional circulation time of the anterior lungs or the regional circulation time of the posterior lungs according to the EIT data changes of the contrast agent in the anterior lungs or the posterior lungs.

[0086] In one embodiment, the front lung region circulation time is obtained by determining the front lung circulation start time and the front lung circulation end time from the front lung EIT data, and then subtracting the front lung circulation start time from the front lung circulation end time.

[0087] In one embodiment, the front pulmonary circulation start time is the moment when the slope of the front pulmonary impedance curve is negative during breath holding, and the front pulmonary circulation end time is the moment when the slope of the front pulmonary impedance curve is positive during breath holding.

[0088] In one embodiment, the posterior lung regional circulation time is obtained by determining the posterior pulmonary circulation start time and the posterior pulmonary circulation end time from the posterior lung EIT data, and then subtracting the posterior pulmonary circulation start time from the posterior pulmonary circulation end time.

[0089] In one embodiment, the posterior pulmonary circulation start time is the moment when the slope of the posterior pulmonary impedance curve is negative during breath holding, and the posterior pulmonary circulation end time is the moment when the slope of the posterior pulmonary impedance curve is positive during breath holding.

[0090] In a specific embodiment, the PTT of the left and right lung regions is further analyzed, such as Figure 5 : Based on the changes of contrast agent in the left (or right) lung image of EIT, the starting time of pulmonary circulation is marked on the left (or right) lung impedance curve (or ) and end time (or ), subtract and get the left (or right) pulmonary circulation time (or ),Right now , .

[0091] In a specific embodiment, PTT of the anterior and posterior lung regions, such as Figure 6 : Based on the changes in lung images before (or after) EIT, the start time of pulmonary circulation is marked on the lung impedance curve before (or after) EIT. (or ) and end time (or ), subtract the front (or back) pulmonary circulation time (or ),Right now , .

[0092] In one embodiment, the present invention establishes the pulmonary circulation time through contrast-enhanced EIT data of the test subject to obtain the pulmonary circulation time, extracts the lung region position information from the EIT data, and then reconstructs the image based on the pulmonary circulation time and the lung region position information to obtain a lung region perfusion time image; the perfusion time of each part (region) of the lung is obtained through the lung region perfusion time image.

[0093] In one embodiment, the method of evaluating pulmonary circulation time based on contrast agent enhanced EIT of the present invention is used to obtain the circulation time of different lung regions, including but not limited to the overall lung circulation time, left lung circulation time, right lung circulation time, upper lung circulation time, and lower lung circulation time; the circulation time of the corresponding region is obtained according to the required lung region.

[0094] The disclosed embodiments of the present invention further provide a computer program product or system, comprising a computer program, which, when executed by a processor, implements the steps of the above-mentioned method for evaluating pulmonary circulation time based on contrast agent enhanced EIT.

[0095] Figure 2 A schematic diagram of a system for evaluating pulmonary circulation time based on contrast agent-enhanced EIT provided in an embodiment of the present invention specifically includes:

[0096] Acquisition unit: acquires the EIT data of the test subject's lungs enhanced by contrast agent;

[0097] Time unit: determining the pulmonary circulation start time and the pulmonary perfusion end time based on the contrast agent-enhanced pulmonary EIT data; the pulmonary circulation start time is the moment when the electrical impedance signal of the contrast agent injected changes while the subject holds his breath, and the pulmonary perfusion end time is the moment when the electrical impedance signal does not change after the contrast agent is injected while the subject holds his breath;

[0098] Calculation unit: subtracts the pulmonary circulation start time from the pulmonary perfusion end time to obtain the pulmonary circulation time.

[0099] Figure 3 A schematic diagram of a device for assessing pulmonary circulation time based on contrast agent-enhanced EIT provided in an embodiment of the present invention specifically includes:

[0100] A memory and a processor; the memory is used to store program instructions; the processor is used to call the program instructions, and when the program instructions are executed, any one of the above-mentioned methods for evaluating pulmonary circulation time based on contrast agent enhanced EIT is performed.

[0101] The disclosed embodiments of the present invention further provide a computer-readable storage medium storing a computer program, which, when executed by a processor, performs any of the above-mentioned methods for evaluating pulmonary circulation time based on contrast agent-enhanced EIT.

[0102] Figure 7 A schematic diagram of an imaging method for a lung regional perfusion time image provided by an embodiment of the present invention, specifically comprising:

[0103] S101: Acquire pulmonary circulation time and lung region location information;

[0104] In one embodiment, the pulmonary circulation time is obtained by one or more of the following methods: obtaining the pulmonary circulation time by nuclear scanning, obtaining the pulmonary circulation time by CT perfusion imaging, obtaining the pulmonary circulation time by magnetic resonance imaging, and obtaining the pulmonary circulation time by echocardiography.

[0105] In one embodiment, the method for obtaining the lung region position information includes:

[0106] Acquire lung imaging data;

[0107] Lung region position information is obtained by extracting position information based on the lung image data.

[0108] In one embodiment, the image data includes one or more of the following: nuclear scanning images, CT perfusion images, magnetic resonance images, and ultrasound images.

[0109] In one embodiment, the lung medical image data further includes EIT images.

[0110] In one embodiment, the pulmonary circulation time is obtained by the above-mentioned method for evaluating pulmonary circulation time based on contrast agent-enhanced EIT.

[0111] In one embodiment, the lung region position information is obtained by using EIT data in the above-mentioned method for estimating pulmonary circulation time based on contrast agent enhanced EIT.

[0112] S102: Perform functional image reconstruction based on the lung circulation time and lung region position information to obtain a lung region perfusion time image.

[0113] In one embodiment, the functional image reconstruction utilizes a reconstruction algorithm to perform data reconstruction.

[0114] The reconstruction algorithms include one or more of the following: algebraic reconstruction algorithm ART, joint algebraic reconstruction algorithm SART, slightly wave back projection method FBP, iterative reconstruction algorithm, image reconstruction algorithm based on Hopfield network, image reconstruction algorithm based on steepest descent BP network, and sparse imaging method based on deep dictionary.

[0115] The basic idea of ​​the ART algorithm is to give the reconstruction area an initial value, generally zero, and then evenly back-project the resulting projection value residuals one by one along the direction of their rays, continuously correcting the image until the required requirements are met, and then ending the iterative process.

[0116] The SART algorithm is the main improvement of the ART algorithm. The main difference between SART and ART is that ART only considers one ray for each correction, while SART uses the correction values ​​of all rays passing through a pixel to iterate.

[0117] The FBP algorithm, developed based on the back-projection method, addresses image sharpness issues by incorporating a filtering function. The FBP algorithm offers fast reconstruction speed and high image quality, making it the most commonly used CT image reconstruction method.

[0118] Although the iterative reconstruction algorithm has a large computational workload and slow reconstruction speed, its calculation results are superior to the FBP algorithm in some aspects, especially in cases of insufficient projection data, missing projection angles, or uneven projection intervals.

[0119] In one embodiment, a method for imaging a lung region perfusion time image includes:

[0120] Based on the data of radionuclide scanning, the lung area position information and lung circulation time are obtained, and the lung area perfusion time image is further constructed based on the lung area position information and lung circulation time;

[0121] Based on the CT perfusion data, the lung region position information and lung circulation time are obtained, and the lung region perfusion time image is further constructed based on the lung region position information and lung circulation time;

[0122] Based on the nuclear magnetic resonance data, the lung region position information and lung circulation time are obtained, and the lung region perfusion time image is further constructed based on the lung region position information and lung circulation time;

[0123] Based on the ultrasound data, the lung region position information and lung circulation time are obtained, and the lung region perfusion time image is further constructed based on the lung region position information and lung circulation time;

[0124] Based on the EIT data, the lung region position information and lung circulation time are obtained, and the lung region perfusion time image is further constructed based on the lung region position information and lung circulation time;

[0125] Based on contrast-enhanced EIT data, lung regional position information and lung circulation time are obtained, and lung regional perfusion time images are further constructed based on the lung regional position information and lung circulation time;

[0126] Pulmonary circulation time is obtained based on radionuclide scanning / CT perfusion / MRI / ultrasound / EIT / contrast agent-enhanced EIT data, and lung regional position information is obtained based on EIT / contrast agent-enhanced EIT data. Lung regional perfusion time images are further constructed based on lung regional position information and pulmonary circulation time.

[0127] In one embodiment, the lung region perfusion time image is as follows: Figure 10 As shown in the figure, each pixel represents the time required for different areas of the blood knife. The darker the color, the longer the perfusion time of the area represented by the pixel, and the lighter the color, the shorter the perfusion time of the area represented by the pixel.

[0128] The disclosed embodiments of the present invention further provide a computer program product or system, including a computer program, which implements the steps of the above-mentioned method for imaging lung regional perfusion time images when executed by a processor.

[0129] Figure 8 A schematic diagram of an imaging system for a lung regional perfusion time image provided by an embodiment of the present invention specifically includes:

[0130] Acquisition module: obtains pulmonary circulation time and lung area location information;

[0131] Reconstruction module: Perform functional image reconstruction based on the lung circulation time and lung area position information to obtain a lung area perfusion time image.

[0132] Figure 9 A schematic diagram of an imaging device for a lung regional perfusion time image provided by an embodiment of the present invention specifically includes:

[0133] A memory and a processor; the memory is used to store program instructions; the processor is used to call the program instructions, and when the program instructions are executed, any one of the above-mentioned imaging methods for lung regional perfusion time images is performed.

[0134] The disclosed embodiments of the present invention further provide a computer-readable storage medium storing a computer program, wherein the computer program, when executed by a processor, performs any of the above-mentioned methods for imaging lung regional perfusion time images.

[0135] An embodiment of the present invention provides a method for evaluating regional perfusion time based on a lung regional perfusion time image, comprising:

[0136] Obtaining a lung regional perfusion time image according to the above-mentioned lung regional perfusion time image imaging method;

[0137] selecting a lung region based on the lung region perfusion time image;

[0138] The number of pixels in the lung region and the pixel values ​​are calculated to obtain the time when perfusion occurs in the lung region.

[0139] In one embodiment, the lung region is a region of any size.

[0140] In one embodiment, the lung region includes one or more of the following: the entire lung region, the left lung region, the right lung region, the front lung region, and the back lung region.

[0141] In one embodiment, the perfusion time of each region of the subject's lungs can be visually observed through the lung region perfusion time image, and the perfusion time of the corresponding region can be accurately calculated according to needs.

[0142] The disclosed embodiments of the present invention further provide a computer program product or system, including a computer program, which, when executed by a processor, implements the steps of the above-mentioned method for regional perfusion time assessment based on lung regional perfusion time images.

[0143] An embodiment of the present invention provides a computer device, specifically comprising:

[0144] A memory and a processor; the memory is used to store program instructions; the processor is used to call the program instructions, and when the program instructions are executed, any one of the above-mentioned regional perfusion time assessment methods based on lung regional perfusion time images is executed.

[0145] An embodiment of the present invention provides a computer-readable storage medium storing a computer program. When the computer program is executed by a processor, any one of the above-mentioned regional perfusion time assessment methods based on lung regional perfusion time images is implemented.

[0146] The validation results of this validation example demonstrate that assigning inherent weights to indications can improve the performance of the present method compared to the default settings. Those skilled in the art will readily appreciate that, for ease of description and brevity, the specific operating processes of the systems, devices, and units described above can be referenced to the corresponding processes in the aforementioned method embodiments and will not be further elaborated upon here. It should be understood that the disclosed systems, devices, and methods can be implemented in other ways within the several embodiments provided herein. For example, the device embodiments described above are merely illustrative. For example, the division of units described is merely a logical functional division. In actual implementation, other divisions may be employed, such as combining or integrating multiple units or components into another system, or omitting or disabling certain features. Furthermore, the coupling, direct coupling, or communication connection shown or discussed may be through interfaces, indirect coupling, or communication connection between devices or units, and may be electrical, mechanical, or other forms. The units described as separate components may or may not be physically separate, and the components shown as units may or may not be physical units, i.e., they may be located in one location or distributed across multiple network units. Some or all of the units may be selected to achieve the objectives of the present embodiment as needed. In addition, the functional units in the various embodiments of the present invention may be integrated into one processing unit, or each unit may exist physically separately, or two or more units may be integrated into one unit. The above-mentioned integrated units may be implemented in the form of hardware or in the form of software functional units. Those skilled in the art will understand that all or part of the steps in the various methods of the above-mentioned embodiments may be completed by instructing the relevant hardware through a program, and the program may be stored in a computer-readable storage medium, which may include: a read-only memory (ROM), a random access memory (RAM), a magnetic disk or an optical disk, etc.

[0147] Those skilled in the art will understand that all or part of the steps in the above-mentioned embodiment method can be implemented by instructing the relevant hardware through a program, and the program can be stored in a computer-readable storage medium. The above-mentioned medium storage can be a read-only memory, a disk or an optical disk, etc.

[0148] The above is a detailed introduction to a computer device provided by the present invention. For those skilled in the art, according to the concept of the embodiments of the present invention, there may be changes in the specific implementation methods and application scope. In summary, the content of this specification should not be understood as limiting the present invention.

Claims

1. A method for evaluating pulmonary circulation time based on contrast agent enhanced EIT, characterized in that: include: S1. Obtaining contrast-enhanced lung EIT data of the test subject; S2. Determine a pulmonary circulation start time and a pulmonary perfusion end time based on the contrast agent-enhanced pulmonary EIT data; the pulmonary circulation start time is the moment when the electrical impedance signal changes after the contrast agent is injected while the subject holds his breath, and the pulmonary perfusion end time is the moment when the electrical impedance signal does not change after the contrast agent is injected while the subject holds his breath; the moment when the impedance curve decreases and the slope of the impedance curve becomes negative during breath holding, with an average value of N end-of-breath impedances before breath holding as a baseline, where N is a natural number greater than 1; The moment when no change occurs is the moment when the slope of the impedance curve is positive and the value is less than 0.01; S3. Subtract the pulmonary circulation start time from the pulmonary perfusion end time to obtain the pulmonary circulation time.

2. The method for evaluating pulmonary circulation time based on contrast agent enhanced EIT according to claim 1, characterized in that: The impedance curve decreases by 5%-10% during breath holding.

3. The method for evaluating pulmonary circulation time based on contrast agent enhanced EIT according to claim 1, characterized in that: The average value of the end-of-breath impedance of 3-5 times before the breath-hold is used as the baseline.

4. The method for evaluating pulmonary circulation time based on contrast agent enhanced EIT according to claim 1, characterized in that: The method further includes evaluating the regional circulation time of the left and right lungs, and performing the left lung regional circulation time evaluation or the right lung regional circulation time evaluation based on the EIT data change of the contrast agent in the left lung or the right lung.

5. The method for evaluating pulmonary circulation time based on contrast agent enhanced EIT according to claim 4, characterized in that: The left lung regional circulation time is obtained by determining the left lung circulation start time and the left lung circulation end time from the left lung EIT data, and then subtracting the left lung circulation start time from the left lung circulation end time.

6. The method for evaluating pulmonary circulation time based on contrast agent enhanced EIT according to claim 5, characterized in that: The left lung circulation start time is the moment when the slope of the left lung impedance curve is negative during breath holding, and the left lung circulation end time is the moment when the slope of the left lung impedance curve is positive during breath holding.

7. The method for evaluating pulmonary circulation time based on contrast agent enhanced EIT according to claim 4, characterized in that: The right lung regional circulation time is obtained by determining the right lung circulation start time and the right lung circulation end time from the right lung EIT data, and then subtracting the right lung circulation start time from the right lung circulation end time.

8. The method for evaluating pulmonary circulation time based on contrast agent enhanced EIT according to claim 7, characterized in that: The right pulmonary circulation start time is the moment when the slope of the right pulmonary impedance curve is negative during breath holding, and the right pulmonary circulation end time is the moment when the slope of the right pulmonary impedance curve is positive during breath holding.

9. The method for evaluating pulmonary circulation time based on contrast agent enhanced EIT according to claim 1, characterized in that: The method further includes evaluating the regional circulation time of the anterior and posterior lungs, and evaluating the regional circulation time of the anterior lungs or the regional circulation time of the posterior lungs according to the EIT data changes of the contrast agent in the anterior lungs or the posterior lungs.

10. The method for evaluating pulmonary circulation time based on contrast agent enhanced EIT according to claim 9, characterized in that: The front lung region circulation time is obtained by determining the front lung circulation start time and the front lung circulation end time from the front lung EIT data, and then subtracting the front lung circulation start time from the front lung circulation end time.

11. The method for evaluating pulmonary circulation time based on contrast agent enhanced EIT according to claim 10, characterized in that: The front pulmonary circulation start time is the moment when the slope of the front pulmonary impedance curve is negative during breath holding, and the front pulmonary circulation end time is the moment when the slope of the front pulmonary impedance curve is positive during breath holding.

12. The method for evaluating pulmonary circulation time based on contrast agent enhanced EIT according to claim 9, characterized in that: The posterior lung regional circulation time is obtained by determining the posterior pulmonary circulation start time and the posterior pulmonary circulation end time from the posterior lung EIT data, and then subtracting the posterior pulmonary circulation start time from the posterior pulmonary circulation end time.

13. The method for evaluating pulmonary circulation time based on contrast agent enhanced EIT according to claim 12, characterized in that: The posterior pulmonary circulation start time is the moment when the slope of the posterior pulmonary impedance curve is negative during breath holding, and the posterior pulmonary circulation end time is the moment when the slope of the posterior pulmonary impedance curve is positive during breath holding.

14. A method for reconstructing a lung regional perfusion time image, characterized in that: include: Obtain pulmonary circulation time and lung regional location information; The pulmonary circulation time is obtained by the method for evaluating pulmonary circulation time based on contrast agent enhanced EIT according to any one of claims 1 to 13; Functional image reconstruction is performed based on the lung circulation time and lung region position information to obtain a lung region perfusion time image.

15. The method for reconstructing a lung regional perfusion time image according to claim 14, characterized in that: The functional image reconstruction utilizes a reconstruction algorithm to perform data reconstruction.

16. The method for reconstructing a lung regional perfusion time image according to claim 14, characterized in that: The method for obtaining the lung region position information includes: Acquire lung imaging data; Lung region position information is obtained by extracting position information based on the lung image data.

17. The method for reconstructing a lung regional perfusion time image according to claim 16, characterized in that: The image data includes one or more of the following: nuclear scanning images, CT perfusion images, magnetic resonance images, and ultrasound images.

18. The method for reconstructing a lung regional perfusion time image according to claim 17, characterized in that: The image data also includes EIT images.

19. The method for reconstructing a lung regional perfusion time image according to claim 14, characterized in that: The lung region position information is obtained by using EIT data in the method for evaluating pulmonary circulation time based on contrast agent enhanced EIT according to claim 1.

20. A method for evaluating lung regional perfusion time based on lung regional perfusion time images, characterized in that: include: Obtaining a lung regional perfusion time image according to the method for reconstructing a lung regional perfusion time image according to any one of claims 14 to 19; selecting a lung region based on the lung region perfusion time image; The number of pixels in the lung region and the pixel values ​​are calculated to obtain the time when perfusion occurs in the lung region.

21. The method for evaluating lung regional perfusion time based on lung regional perfusion time images according to claim 20, characterized in that: The lung region is a region of any size.

22. The method for evaluating lung regional perfusion time based on lung regional perfusion time images according to claim 20, characterized in that: The lung region includes one or more of the following: the entire lung region, the left lung region, the right lung region, the front lung region, and the back lung region.

23. A computer program product having a computer program thereon, characterized in that include: The computer program is executed by a processor to implement the method for evaluating pulmonary circulation time based on contrast agent enhanced EIT as described in any one of claims 1-13, or to implement the method for reconstructing a lung regional perfusion time image as described in any one of claims 14-19; or to implement the method for evaluating lung regional perfusion time based on a lung regional perfusion time image as described in any one of claims 20-22.

24. A computer device comprising a memory and a processor and a computer program stored in the memory, characterized in that The computer program is executed by the processor to implement the method for evaluating pulmonary circulation time based on contrast agent enhanced EIT as described in any one of claims 1-13, or to implement the method for reconstructing a lung regional perfusion time image as described in any one of claims 14-19; or to implement the method for evaluating lung regional perfusion time based on a lung regional perfusion time image as described in any one of claims 20-22.

25. A computer-readable storage medium having a computer program stored thereon, characterized in that: include: The computer program is executed by a processor to implement the method for evaluating pulmonary circulation time based on contrast agent enhanced EIT as described in any one of claims 1-13, or to implement the method for reconstructing a lung regional perfusion time image as described in any one of claims 14-19; or to implement the method for evaluating lung regional perfusion time based on a lung regional perfusion time image as described in any one of claims 20-22.

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