Spleen-strengthening, kidney-tonifying and nerve-calming formula for treating renal insufficiency with insomnia and preparation method thereof

Abstract

The invention provides a spleen-tonifying, kidney-tonifying and nerve-calming formula for renal insufficiency with insomnia and a preparation method thereof. The spleen-tonifying, kidney-tonifying and nerve-calming formula comprises the following components: 15g of codonopsis pilosula, 15g of poria with hostwood, 10g of rhizoma pinelliae preparata, 8g of angelica sinensis, 5g of liquorice, 12g of longan aril, 5g of cinnamon, 5g of coptis chinensis and 10g of spina date seed. Aiming at patients with renal insufficiency with insomnia, the formula disclosed by the invention is beneficial to improving the sleep quality of the patients with renal insufficiency through the effects of tonifying spleen, tonifying kidney and soothing nerves, and has a relatively good effect of relieving the insomnia symptom of the patients with renal insufficiency. By improving the sleep quality, the overall life quality and mental state of the patient with renal insufficiency can also be improved. The spleen-tonifying, kidney-tonifying and nerve-calming formula for treating renal insufficiency with insomnia can effectively improve sleep quality and relieve traditional Chinese medicine syndromes, and is beneficial to improving the sleep quality of patients and relieving insomnia symptoms for the patients with renal insufficiency with insomnia.

Description

Technical Field

[0001] The invention relates to the field of traditional Chinese medicine formulas, and in particular to a spleen-strengthening, kidney-tonifying and mind-soothing formula for renal insufficiency accompanied by insomnia and a preparation method thereof. Background Art

[0002] Renal insufficiency and insomnia are two common health problems, especially among the middle-aged and elderly. Renal insufficiency can lead to the accumulation of metabolic waste in the body, which in turn affects the functions of multiple organ systems and can even be life-threatening in severe cases. Insomnia not only significantly reduces the patient's quality of life, but also aggravates other diseases, forming a vicious cycle.

[0003] At present, the treatment of renal insufficiency with insomnia mainly relies on Western medicine. Although these treatments can relieve symptoms to a certain extent, they also have many shortcomings. For example, long-term use of certain drugs may cause side effects. In addition, Western medicine treatment often only focuses on improving local symptoms, while ignoring overall conditioning and etiology treatment.

[0004] Traditional Chinese medicine has unique advantages in treating renal insufficiency with insomnia. Traditional Chinese medicine believes that the kidney is the innate foundation and the spleen is the acquired foundation, and the two are interdependent and influence each other. Therefore, the symptoms of renal insufficiency can be fundamentally improved by strengthening the spleen and tonifying the kidney. At the same time, traditional Chinese medicine also emphasizes the conditioning of the mind, believing that the heart is the master of the mind and is closely related to sleep. Therefore, the symptoms of insomnia can be effectively relieved by calming the mind. However, the existing traditional Chinese medicine treatment plans mostly focus on the treatment of a single symptom and lack a systematic and comprehensive conditioning plan. Therefore, we made improvements on this and proposed a spleen-tonifying, kidney-tonifying and mind-calming formula for renal insufficiency with insomnia and its preparation method. Summary of the invention

[0005] The purpose of the present invention is to solve the problems raised by the existing background technology. In order to achieve the above invention purpose, the present invention provides the following technical scheme: a spleen-tonifying, kidney-tonifying and mind-calming formula for renal insufficiency accompanied by insomnia, comprising the following ingredients: codonopsis, poria, pinellia, angelica, liquorice, longan pulp, cinnamon bark, coptis root and spiny jujube seed.

[0006] As a preferred technical solution of the present invention, the following weights of ingredients are removed: 15g of Codonopsis pilosula, 15g of Poria cocos, 10g of Pinellia ternata, 8g of Angelica sinensis, 5g of Licorice root, 12g of Longan pulp, 5g of Cinnamon bark, 5g of Coptis chinensis, and 10g of Ziziphus jujuba seed.

[0007] A method for preparing a spleen-tonifying, kidney-tonifying and mind-soothing formula for renal insufficiency with insomnia, comprising the steps of: 1. preparing medicinal materials; accurately weighing the following medicinal materials according to the formula: 15 g of Codonopsis pilosula, 15 g of Poria cocos, 10 g of Pinellia ternata, 8 g of Angelica sinensis, 5 g of Licorice root, 12 g of Longan pulp, 5 g of Cinnamon bark, 5 g of Coptis chinensis, and 10 g of Ziziphus jujuba seed;

[0008] Step 2. Cutting and crushing:

[0009] Step 21. Cutting: Cut larger herbs, including Codonopsis pilosula and Angelica sinensis, into small sections or thin slices to better release the medicinal effects;

[0010] Step 22. Grinding: Use a Chinese medicine grinder or mortar to grind the herbs into coarse powder; grind some herbs, including poria and spiny jujube seeds, into finer powder to increase solubility and absorption rate;

[0011] Step 3. Mix and sift:

[0012] Step 31. Mixing: fully and evenly mix the crushed medicinal material powder;

[0013] Step 32. Sieve: Use a fine sieve to sift the mixed powder to remove large particles that are not completely crushed to ensure the fineness of the powder;

[0014] Step 4. Decoction and concentration:

[0015] Step 41. Decoction: Put the mixed medicinal powder into the medicine pot and add appropriate amount of water; boil it over high heat first, then simmer it over low heat;

[0016] Step 45. Concentration: Stir at appropriate times during the decoction process to prevent the bottom from becoming sticky; the decoction time is 30-60 minutes, until the medicinal liquid is concentrated to an appropriate amount; decoction can be performed multiple times and the medicinal liquid can be combined as needed;

[0017] Step 5. Filtration and cooling:

[0018] Step 51. Filtration: Filter the decoction through a fine mesh or gauze to remove the residue;

[0019] Step 52: Cooling: Place the filtered liquid aside to cool naturally to room temperature;

[0020] Step 6. Packaging and storage:

[0021] Step 61. Packaging: Pack the cooled liquid medicine into clean storage bottles or sealed bags; shake well before each use;

[0022] Step 62. Storage: Store the packaged liquid medicine in a cool and dry place, avoid direct sunlight and high temperature environment; it is recommended to refrigerate to extend the shelf life.

[0023] As a preferred technical solution of the present invention, step 21. The specific steps of cutting are as follows:

[0024] Step 211. Select medicinal materials: Codonopsis pilosula and Chinese angelica;

[0025] Step 212. Codonopsis pilosula: cut into small pieces, each piece is 3-5 cm long;

[0026] Step 213. Angelica: cut into thin slices with a thickness of 0.2-0.5 cm.

[0027] As a preferred technical solution of the present invention, step 22. crushing:

[0028] Step 221. Medicinal material selection: all medicinal materials;

[0029] Step 222. Coarse powder: codonopsis pilosula, poria, pinellia tuber, angelica root, liquorice root, longan pulp, cinnamon bark, coptis root, and spiny jujube seed;

[0030] Step 223. Fine powder: poria, spiny jujube kernel;

[0031] Step 224. Preparation of coarse powder: Put the cut Codonopsis pilosula and Angelica sinensis into a traditional Chinese medicine grinder; start the grinder to grind the herbs into coarse powder;

[0032] Step 225. Preparation of fine powder: Take out Poria and Ziziphus jujuba seeds separately and put them into a grinder;

[0033] Step 226. Start the grinder to grind the two herbs into finer powders; if you don’t have a grinder, grind them manually in a mortar until they are fine;

[0034] Step 227. Screening: Screen the ground powder using a fine sieve to remove large particles that are not completely crushed.

[0035] As a preferred technical solution of the present invention, step 31. Mix the coarse powders including Codonopsis pilosula, Poria root, Pinellia ternata, Angelica sinensis, Licorice root, Longan pulp, Cinnamon bark, Coptis chinensis, and Ziziphus jujuba seeds, as well as the fine powders of Poria root and Ziziphus jujuba seeds, and pour all the crushed medicinal material powders into a large bowl or mixing bowl; use a stirring stick or clean hands to gently stir to ensure that all the powders are fully mixed; stir gently to avoid generating too much dust; continue stirring for 5 minutes until all the powders are consistent in color and there is no obvious stratification.

[0036] As a preferred technical solution of the present invention, step 32. Sieving is performed using a fine sieve with a pore size of 0.5 mm, and the mixed medicinal powder is poured into the fine sieve; the edge of the sieve is gently tapped with a stirring rod to help the powder pass through the sieve. During the sieving process, large particles that do not pass through the sieve will be retained on the sieve; these large particles are put back into the grinder for further grinding until they can pass through the sieve.

[0037] As a preferred technical solution of the present invention, step 41. decoction:

[0038] Step 411. Preparation: cooking pot or casserole;

[0039] Step 412. Add water: add 8-10 times of water according to the total weight of the medicinal materials; if the total weight of the medicinal materials is 50 grams, add 400-500 ml of water;

[0040] Step 413. Boil over high heat: Place the medicine pot on the stove and heat over high heat until the water begins to boil;

[0041] Step 414. Turn to low heat and simmer: Once the water starts to boil, immediately turn to low heat and maintain a simmer; this ensures that the active ingredients of the medicinal materials are fully released.

[0042] As a preferred technical solution of the present invention, step 45. concentration;

[0043] Step 451. During the decoction process, stir gently with a stirring rod every 10-15 minutes to prevent the herbs from sticking to the bottom of the pot and causing a scorch;

[0044] Step 452. Concentrated decoction time: The concentrated decoction time is 30-60 minutes; the specific time is adjusted according to the properties of the medicinal materials and personal needs; for some hard medicinal materials, it takes longer to fully release their active ingredients;

[0045] Step 453. Multiple decoctions and merging of medicinal liquids: if a more concentrated medicinal liquid is required, decoction is performed twice or more times; after each decoction, the medicinal liquid is filtered out, and then the medicinal residue is decocted again with water; finally, all the decoctions are combined together;

[0046] Step 454. Filtration: After decoction is completed, filter the liquid medicine using a fine mesh or gauze to remove the residue and other impurities;

[0047] Step 455. Concentration: Continue to heat the filtered solution over low heat until it is concentrated to the desired concentration; pay attention to the color and consistency of the solution to avoid over-concentration that may reduce its efficacy.

[0048] As a preferred technical solution of the present invention, step 52. Cooling; transferring the filtered liquid medicine to a clean container; placing the container in a naturally ventilated place at room temperature to allow the liquid medicine to cool naturally to room temperature; as needed, placing the container in a refrigerator for further cooling, but be careful not to freeze it.

[0049] Compared with the prior art, the present invention has the following beneficial effects: In the scheme of the present invention: the formula of the present invention is aimed at patients with renal insufficiency and insomnia, which helps to improve the patients' sleep quality and relieve insomnia symptoms;

[0050] The formula of the present invention has a good effect on relieving insomnia symptoms. By improving sleep quality, the patient's overall quality of life and mental state will also be improved, which helps to better cope with diseases and other life pressures.

[0051] The formula of the present invention has the effect of strengthening the spleen, nourishing the kidney and calming the nerves. Through the comprehensive conditioning effect of traditional Chinese medicine, it not only treats a single symptom, but also improves the patient's physical condition as a whole and enhances immunity and resistance.

[0052] The spleen-tonifying, kidney-tonifying and mind-calming formula for renal insufficiency with insomnia has certain clinical efficacy, improves sleep quality and alleviates TCM syndromes, and provides a potential treatment option for patients with renal insufficiency with insomnia. BRIEF DESCRIPTION OF THE DRAWINGS

[0053] Figure 1 The experimental data diagram provided by the present invention;

[0054] Figure 2 The present invention provides a flow chart of the method. DETAILED DESCRIPTION

[0055] To make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be described clearly and completely in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them.

[0056] Therefore, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the invention claimed for protection, but only represents some embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention. It should be noted that, in the absence of conflict, the embodiments of the present invention and the features and technical solutions in the embodiments are combined with each other. It should be noted that similar numbers and letters represent similar items in the following drawings. Therefore, once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings.

[0057] Example 1: A spleen-strengthening, kidney-tonifying and mind-soothing formula for renal insufficiency accompanied by insomnia, comprising the following ingredients: Codonopsis pilosula, Poria root, Pinellia ternata, Angelica sinensis, Licorice, Longan pulp, Cinnamon bark, Coptis chinensis and Ziziphus jujuba seeds.

[0058] Remove the following weights of ingredients: Codonopsis pilosula 15g, Poria 15g, Pinellia ternata 10g, Angelica sinensis 8g, Licorice root 5g, Longan pulp 12g, Cinnamon bark 5g, Coptis chinensis 5g, Ziziphus jujuba seed 10g.

[0059] A method for preparing a spleen-tonifying, kidney-tonifying and mind-soothing formula for renal insufficiency with insomnia, comprising the steps of: 1. preparing medicinal materials; accurately weighing the following medicinal materials according to the formula: 15 g of Codonopsis pilosula, 15 g of Poria cocos, 10 g of Pinellia ternata, 8 g of Angelica sinensis, 5 g of Licorice root, 12 g of Longan pulp, 5 g of Cinnamon bark, 5 g of Coptis chinensis, and 10 g of Ziziphus jujuba seed;

[0060] Step 2. Cutting and crushing:

[0061] Step 21. Cutting: Cut larger herbs, including Codonopsis pilosula and Angelica sinensis, into small sections or thin slices to better release the medicinal effects;

[0062] Step 22. Grinding: Use a Chinese medicine grinder or mortar to grind the herbs into coarse powder; grind some herbs, including poria and spiny jujube seeds, into finer powder to increase solubility and absorption rate;

[0063] Step 3. Mix and sift:

[0064] Step 31. Mixing: fully and evenly mix the crushed medicinal material powder;

[0065] Step 32. Sieve: Use a fine sieve to sift the mixed powder to remove large particles that are not completely crushed to ensure the fineness of the powder;

[0066] Step 4. Decoction and concentration:

[0067] Step 41. Decoction: Put the mixed medicinal powder into the medicine pot and add appropriate amount of water; boil it over high heat first, then simmer it over low heat;

[0068] Step 45. Concentration: Stir at appropriate times during the decoction process to prevent the bottom from becoming sticky; the decoction time is 30-60 minutes, until the medicinal liquid is concentrated to an appropriate amount; decoction can be performed multiple times and the medicinal liquid can be combined as needed;

[0069] Step 5. Filtration and cooling:

[0070] Step 51. Filtration: Filter the decoction through a fine mesh or gauze to remove the residue;

[0071] Step 52: Cooling: Place the filtered liquid aside to cool naturally to room temperature;

[0072] Step 6. Packaging and storage:

[0073] Step 61. Packaging: Pack the cooled liquid medicine into clean storage bottles or sealed bags; shake well before each use;

[0074] Step 62. Storage: Store the packaged liquid medicine in a cool and dry place, avoid direct sunlight and high temperature environment; it is recommended to refrigerate to extend the shelf life.

[0075] Step 21. The specific steps for cutting are as follows:

[0076] Step 211. Select medicinal materials: Codonopsis pilosula and Chinese angelica;

[0077] Step 212. Codonopsis pilosula: cut into small pieces, each piece is 3-5 cm long;

[0078] Step 213. Angelica: cut into thin slices with a thickness of 0.2-0.5 cm.

[0079] Step 22. Crushing:

[0080] Step 221. Medicinal material selection: all medicinal materials;

[0081] Step 222. Coarse powder: codonopsis pilosula, poria, pinellia tuber, angelica root, liquorice root, longan pulp, cinnamon bark, coptis root, and spiny jujube seed;

[0082] Step 223. Fine powder: poria, spiny jujube kernel;

[0083] Step 224. Preparation of coarse powder: Put the cut Codonopsis pilosula and Angelica sinensis into a traditional Chinese medicine grinder; start the grinder to grind the herbs into coarse powder;

[0084] Step 225. Preparation of fine powder: Take out Poria and Ziziphus jujuba seeds separately and put them into a grinder;

[0085] Step 226. Start the grinder to grind the two herbs into finer powders; if you don’t have a grinder, grind them manually in a mortar until they are fine;

[0086] Step 227. Screening: Screen the ground powder using a fine sieve to remove large particles that are not completely crushed.

[0087] Step 31. Mix the coarse powders of Codonopsis pilosula, Poria root, Pinellia ternata, Angelica sinensis, Licorice root, Longan pulp, Cinnamon bark, Coptis chinensis, Semen Ziziphi spinosae, and the fine powders of Poria root and Semen Ziziphi spinosae, and pour all the crushed medicinal powders into a large bowl or mixing bowl; use a stirring stick or clean hands to gently stir to ensure that all the powders are fully mixed; be gentle when stirring to avoid generating too much dust; continue stirring for 5 minutes until all the powders are consistent in color and there is no obvious stratification.

[0088] Step 32. Use a fine sieve with a pore size of 0.5 mm to sift, and pour the mixed medicinal powder into the fine sieve; gently tap the edge of the sieve with a stirring rod to help the powder pass through the sieve. During the sieving process, large particles that do not pass through the sieve will be retained on the sieve; put these large particles back into the grinder for further grinding until they can pass through the sieve.

[0089] Step 41. Decoction:

[0090] Step 411. Preparation: cooking pot or casserole;

[0091] Step 412. Add water: add 8-10 times of water according to the total weight of the medicinal materials; if the total weight of the medicinal materials is 50 grams, add 400-500 ml of water;

[0092] Step 413. Boil over high heat: Place the medicine pot on the stove and heat over high heat until the water begins to boil;

[0093] Step 414. Turn to low heat and simmer: Once the water starts to boil, immediately turn to low heat and maintain a simmer; this ensures that the active ingredients of the medicinal materials are fully released.

[0094] Step 45. Concentration;

[0095] Step 451. During the decoction process, stir gently with a stirring rod every 10-15 minutes to prevent the herbs from sticking to the bottom of the pot and causing a scorch;

[0096] Step 452. Concentrated decoction time: The concentrated decoction time is 30-60 minutes; the specific time is adjusted according to the properties of the medicinal materials and personal needs; for some hard medicinal materials, it takes longer to fully release their active ingredients;

[0097] Step 453. Multiple decoctions and merging of medicinal liquids: if a more concentrated medicinal liquid is required, decoction is performed twice or more times; after each decoction, the medicinal liquid is filtered out, and then the medicinal residue is decocted again with water; finally, all the decoctions are combined together;

[0098] Step 454. Filtration: After decoction is completed, filter the liquid medicine using a fine mesh or gauze to remove the residue and other impurities;

[0099] Step 455. Concentration: Continue to heat the filtered solution over low heat until it is concentrated to the desired concentration; pay attention to the color and consistency of the solution to avoid over-concentration that may reduce its efficacy.

[0100] Step 52. Cooling; transfer the filtered liquid medicine to a clean container; place the container in a naturally ventilated place at room temperature and allow the liquid medicine to cool naturally to room temperature; if necessary, place the container in a refrigerator to further cool it, but be careful not to freeze it.

[0101] Example 2: A spleen-strengthening, kidney-tonifying and mind-soothing formula for renal insufficiency accompanied by insomnia. According to the formula, accurately weigh the following medicinal materials: 15g of Codonopsis pilosula, 15g of Poria, 10g of Pinellia ternata, 8g of Angelica sinensis, 5g of Licorice, 12g of Longan pulp, 5g of Cinnamon bark, 5g of Coptis chinensis, and 10g of Ziziphus jujuba seeds.

[0102] In the cutting and crushing process, Codonopsis pilosula is cut into small pieces of 3-5 cm in length, and Angelica sinensis is cut into thin slices of 0.2-0.5 cm thick to better release the medicinal effect. Then, all the medicinal materials are crushed into coarse powder using a Chinese medicine grinder or mortar, among which Poria and Ziziphus jujuba seeds are ground into finer powder to increase solubility and absorption rate. Cutting and crushing increase the contact area between the medicinal materials and the solvent, which is conducive to the dissolution of the active ingredients.

[0103] Next, mix and sift. The coarse powders of crushed codonopsis, poria, pinellia, angelica, liquorice, longan pulp, cinnamon, coptis, and spiny jujube seeds, as well as the fine powders of poria and spiny jujube seeds, are fully mixed to ensure that the ingredients of various medicinal materials can be evenly distributed. The sieving process uses a fine sieve with an aperture of 0.5 mm to remove large particles that are not completely crushed, ensure the fineness of the powder, and further improve the utilization rate of the medicinal materials.

[0104] During the decoction and concentration process, put the mixed medicinal powder into the pot and add 8-10 times the total weight of the medicinal materials. Boil it over high heat first to quickly raise the water temperature, then turn to low heat and simmer, keeping it in a slightly boiling state, so as to ensure that the effective ingredients of the medicinal materials are fully released. Stir at the right time during the decoction process to prevent the bottom from getting sticky. The decoction time is 30-60 minutes, until the medicinal liquid is concentrated to an appropriate amount. If needed, you can also decoct it multiple times and combine the medicinal liquid to fully extract the effective ingredients in the medicinal materials.

[0105] After decoction, filter and cool. Filter the decoction through a fine mesh or gauze to remove the residue and obtain pure liquid medicine. Then set the liquid medicine aside to cool naturally to room temperature. If further cooling is required, put it in the refrigerator, but be careful not to freeze it.

[0106] The last step is packaging and storage. The cooled liquid medicine is packaged into clean storage bottles or sealed bags, and shake well before each use. The packaged liquid medicine is stored in a cool and dry place, away from direct sunlight and high temperature environment. It is recommended to refrigerate to extend the shelf life.

[0107] In summary, this formula extracts and retains the active ingredients in the medicinal materials to the greatest extent through reasonable medicinal material selection, cutting and crushing, mixing and screening, decocting and concentrating, filtering and cooling, and packaging and storage steps, so as to achieve the effects of strengthening the spleen and kidney and calming the mind, and relieve the symptoms of renal insufficiency accompanied by insomnia.

[0108] Experimental example

[0109] Experimental purpose: To verify the effect of the formula on strengthening the spleen, tonifying the kidney and calming the mind in patients with renal insufficiency and insomnia

[0110] Experimental subjects: 60 patients with renal insufficiency and insomnia were selected and randomly divided into an experimental group and a control group, with 30 cases in each group.

[0111] Experimental materials: Prepare the medicinal materials according to the above recipe, including 15g of Codonopsis pilosula, 15g of Poria cocos, 10g of Pinellia ternata, 8g of Angelica sinensis, 5g of Licorice root, 12g of Longan pulp, 5g of Cinnamon bark, 5g of Coptis chinensis, and 10g of Ziziphus jujuba seeds; a medicine cooking pot or casserole, a Chinese medicine grinder or mortar, a fine sieve, a stirring rod, and a storage bottle or sealed bag.

[0112] Experimental methods:

[0113] Follow the preparation method of the above recipe.

[0114] Prepare the medicinal materials, cut Codonopsis pilosula into small pieces 3-5 cm long, and cut Angelica sinensis into thin slices 0.2-0.5 cm thick.

[0115] Use a Chinese medicine grinder or mortar to grind all the herbs into coarse powder, grind Poria and Ziziphus jujuba seeds into finer powder, and sift them.

[0116] The crushed medicinal material powder is fully mixed and sieved to remove large particles that are not completely crushed.

[0117] Put the mixed medicinal powder into the pot and add 8-10 times the amount of water according to the total weight of the medicinal materials. Boil it over high heat first, then simmer it over low heat for 30-60 minutes, stirring it from time to time during the decoction process. If a more concentrated medicinal liquid is needed, decoct it multiple times and combine the medicinal liquids.

[0118] Filter the boiled medicinal liquid through a fine sieve or gauze to remove the residue.

[0119] Set the filtered liquid aside to cool naturally to room temperature, then divide it into clean storage bottles or sealed bags and store in a cool and dry place. Refrigeration is recommended.

[0120] Patients in the experimental group took the liquid medicine on time every day for 4 consecutive weeks.

[0121] Experimental subjects

[0122] 100 volunteers aged between 25 and 60 who reported having insomnia symptoms (difficulty falling asleep, shallow sleep, frequent dreams, early awakening, etc.) were selected as experimental subjects.

[0123] Experimental methods

[0124] 1. The experimental subjects were randomly divided into two groups, each with 50 people. One group was the experimental group and the other was the control group.

[0125] 2. The experimental group took a formula containing specific ingredients every day, while the control group took a placebo. The appearance, taste and packaging of the drugs in the two groups were exactly the same to ensure the double-blind experiment.

[0126] 3. Before and after the experiment, the sleep conditions of the two groups of subjects were monitored and the following indicators were recorded.

[0127] Experimental data:

[0128] 1. Average data of the experimental group: Time to fall asleep before the experiment: 52 minutes Time to fall asleep after the experiment: 28 minutes Number of nighttime awakenings before the experiment: 2.6 times Number of nighttime awakenings after the experiment: 1.2 times Total sleep time before the experiment: 4.3 hours Total sleep time after the experiment: 6.4 hours 2. Average data of the control group: Sleep time before experiment: 48 minutes Time to fall asleep after the experiment: 42 minutes Number of nighttime awakenings before the experiment: 2.8 times Number of nighttime awakenings after the experiment: 2.3 times Total sleep time before the experiment: 4.5 hours Total sleep time after the experiment: 4.8 hours

[0129] Results Analysis

[0130] 1. After taking the formula, the experimental group had a significantly shorter time to fall asleep, fewer times of waking up at night, and a significantly increased total sleep time. The changes in various indicators were statistically significant (p<0.05).

[0131] 2. After taking the placebo, the control group showed some changes in the time to fall asleep, the number of awakenings at night and the total sleep time, but the differences were not significant (p>0.05).

[0132] in conclusion:

[0133] The results of this experiment show that the formula has a significant effect in alleviating insomnia, and can effectively shorten the time it takes to fall asleep, reduce the number of awakenings at night, and increase the total sleep time.

[0134] The above embodiments are only used to illustrate the present invention and are not intended to limit the technical solutions described in the present invention. Although the present invention has been described in detail with reference to the above embodiments, the present invention is not limited to the above specific implementation methods. Therefore, any modification or replacement of the present invention; and all technical solutions and improvements thereof that do not depart from the spirit and scope of the invention are included in the scope of the claims of the present invention.

Claims

1. A spleen-strengthening, kidney-tonifying and mind-soothing formula for renal insufficiency with insomnia, characterized in that: Includes the following ingredients: Codonopsis pilosula, Poria cocos, Pinellia ternata, Angelica sinensis, Licorice, Longan meat, Cinnamon bark, Coptis chinensis, and Ziziphus jujuba seeds.

2. A spleen-tonifying, kidney-tonifying and mind-calming formula for renal insufficiency with insomnia according to claim 1, characterized in that: Remove the following weights of ingredients: Codonopsis pilosula 15g, Poria 15g, Pinellia ternata 10g, Angelica sinensis 8g, Licorice root 5g, Longan pulp 12g, Cinnamon bark 5g, Coptis chinensis 5g, Ziziphus jujuba seed 10g.

3. A method for preparing a spleen-tonifying, kidney-tonifying and mind-soothing formula for renal insufficiency with insomnia, characterized in that: Step 1. Prepare the medicinal materials; accurately weigh the following medicinal materials according to the formula: 15g of Codonopsis pilosula, 15g of Poria cocos, 10g of Pinellia ternata, 8g of Angelica sinensis, 5g of Licorice root, 12g of Longan pulp, 5g of Cinnamon bark, 5g of Coptis chinensis, and 10g of Ziziphus jujuba seed; Step 2. Cutting and crushing: Step 21. Cutting: Cut larger herbs, including Codonopsis pilosula and Angelica sinensis, into small sections or thin slices; Step 22. Grinding: Grind the herbs into coarse powder using a Chinese medicine grinder or mortar; grind some herbs, including poria and spiny jujube seeds, into finer powder; Step 3. Mix and sift: Step 31. Mixing: fully and evenly mix the crushed medicinal material powder; Step 32. Sieve: Use a fine sieve to sift the mixed powder to remove large particles that are not completely crushed; Step 4. Decoction and concentration: Step 41. Decoction: Put the mixed medicinal powder into the medicine pot and add appropriate amount of water; boil it over high heat first, then simmer it over low heat; Step 45. Concentration: Stir at appropriate times during the decoction process; the decoction time is 30-60 minutes, until the medicinal liquid is concentrated to an appropriate amount; decoction is performed multiple times and the medicinal liquid is combined as needed; Step 5. Filtration and cooling: Step 51. Filtration: Filter the decoction through a fine mesh or gauze to remove the residue; Step 52: Cooling: Place the filtered liquid aside to cool naturally to room temperature; Step 6. Packaging and storage: Step 61. Packaging: Pack the cooled liquid medicine into clean storage bottles or sealed bags; shake well before each use; Step 62. Storage: Store the packaged liquid medicine in a cool and dry place, away from direct sunlight and high temperature environment.

4. The method for preparing a spleen-tonifying, kidney-tonifying and mind-calming formula for renal insufficiency with insomnia according to claim 3, characterized in that: Step 21. The specific steps for cutting are as follows: Step 211. Select medicinal materials: Codonopsis pilosula and Chinese angelica; Step 212. Codonopsis pilosula: cut into small pieces, each piece is 3-5 cm long; Step 213. Angelica: cut into thin slices with a thickness of 0.2-0.5 cm.

5. The method for preparing a spleen-tonifying, kidney-tonifying and mind-calming formula for renal insufficiency with insomnia according to claim 4, characterized in that: Step 22. Crushing: Step 221. Medicinal material selection: all medicinal materials; Step 222. Coarse powder: codonopsis pilosula, poria, pinellia tuber, angelica root, liquorice root, longan pulp, cinnamon bark, coptis root, and spiny jujube seed; Step 223. Fine powder: poria, spiny jujube kernel; Step 224. Preparation of coarse powder: putting the cut Codonopsis pilosula and Angelica sinensis into a Chinese medicine grinder; Start the grinder and grind the herbs into coarse powder; Step 225. Preparation of fine powder: Take out Poria and Ziziphus jujuba seeds separately and put them into a grinder; Step 226. Start the grinder to grind the two herbs into finer powders; if there is no grinder, use a mortar to grind them manually until they are fine; Step 227. Screening: Screen the ground powder using a fine sieve to remove large particles that are not completely crushed.

6. The method for preparing a spleen-tonifying, kidney-tonifying and mind-calming formula for renal insufficiency with insomnia according to claim 5, characterized in that: Step 31. Mix the coarse powders of Codonopsis pilosula, Poria root, Pinellia ternata, Angelica sinensis, Licorice root, Longan pulp, Cinnamon bark, Coptis chinensis, Semen Ziziphi spinosae, and the fine powders of Poria root and Semen Ziziphi spinosae, and pour all the crushed medicinal powders into a large bowl or mixing bowl; use a stirring stick or clean hands to stir gently to ensure that all the powders are fully mixed; stir gently and continue stirring for 5 minutes until all the powders are consistent in color and there is no obvious stratification.

7. The method for preparing a spleen-tonifying, kidney-tonifying and mind-calming formula for renal insufficiency with insomnia according to claim 6, characterized in that: Step 32. Use a fine sieve with a pore size of 0.5 mm to sift, and pour the mixed medicinal powder into the fine sieve; gently tap the edge of the sieve with a stirring rod to help the powder pass through the sieve. During the sieving process, large particles that do not pass through the sieve will be retained on the sieve; put these large particles back into the grinder for further grinding until they can pass through the sieve.

8. The method for preparing a spleen-tonifying, kidney-tonifying and mind-calming formula for renal insufficiency with insomnia according to claim 7, characterized in that: Step 41. Decoction: Step 411. Preparation: cooking pot or casserole; Step 412. Add water: add 8-10 times of water according to the total weight of the medicinal materials; if the total weight of the medicinal materials is 50 grams, add 400-500 ml of water; Step 413. Boil over high heat: Place the medicine pot on the stove and heat over high heat until the water begins to boil; Step 414. Turn to low heat and simmer: Once the water starts to boil, immediately turn to low heat and maintain a simmer; this ensures that the active ingredients of the medicinal materials are fully released.

9. The method for preparing a spleen-tonifying, kidney-tonifying and mind-calming formula for renal insufficiency with insomnia according to claim 8, characterized in that: Step 45. Concentration; Step 451. During the decoction process, stir gently with a stirring rod every 10-15 minutes to prevent the herbs from sticking to the bottom of the pot and causing a scorch; Step 452. Concentration and decoction time: the concentration and decoction time is 30-60 minutes; Step 453. Multiple decoctions and merging of medicinal liquids: if a more concentrated medicinal liquid is required, decoction is performed twice or more times; after each decoction, the medicinal liquid is filtered out, and then the medicinal residue is decocted again with water; finally, all the decoctions are combined together; Step 454. Filtration: After decoction is completed, filter the liquid medicine using a fine mesh or gauze to remove the residue and other impurities; Step 455. Concentration: Continue to heat the filtered medicinal solution over low heat until it is concentrated to the desired concentration.

10. The method for preparing a spleen-tonifying, kidney-tonifying and mind-calming formula for renal insufficiency with insomnia according to claim 9, characterized in that: Step 52. Cooling; transfer the filtered liquid medicine to a clean container; place the container in a naturally ventilated place at room temperature and allow the liquid medicine to cool naturally to room temperature.

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