Lip skin protective agent and preparation method thereof

Abstract

The invention relates to the technical field of cosmetics, and particularly discloses a lip skin protective agent and a preparation method thereof. The invention relates to a lip skin protective agent, which is prepared from the following raw materials in percentage by mass: 36 to 75 percent of squalane, 10 to 30 percent of natural vegetable fat, 7.3 to 21 percent of active substances, 2 to 7 percent of glyceryl behenate, 1 to 6 percent of lecithin, 1 to 6 percent of polyglycerol-4 isostearate and 0.1 to 2 percent of antioxidants. The active substances comprise 7 to 15 percent of phytosterol, 0.1 to 4 percent of ceramide and 0.2 to 2 percent of palmitoyl active peptide. The lip skin protective agent is in an ointment dosage form, can be used for lip care, and has the advantages of effectively improving ecdysis and chapping of lips, fading cheilogramma and improving the barrier and anti-irritation ability of the lip skin.

Description

Technical Field

[0001] The present application relates to the technical field of cosmetics, and more specifically, to a lip skin protectant and a preparation method thereof. Background Art

[0002] The thickness of the lip skin is only 1 / 3 of that of the body skin. It is one of the most sensitive and delicate areas of the face and is easily damaged by external environmental factors such as dryness, cold and ultraviolet rays.

[0003] The lip skin has no sweat glands, hair follicles, or sebaceous glands, and does not have the ability to secrete oil and regulate moisture. The moisture retained in the lips is very easy to evaporate and disappear, so it is easy to become dehydrated, causing peeling and chapped skin. With age, the body gradually loses collagen, and the lip skin gradually loses elasticity, resulting in lip wrinkles, which affects the appearance. Therefore, it is particularly important to develop a lip skin care product that can improve the lip peeling and chapped problems, reduce lip wrinkles, and enhance the lip skin barrier and anti-irritation ability.

[0004] With respect to the above-mentioned related technologies, the inventors found that although traditional lip care products can moisturize the lips to a certain extent, they often have the problem of insufficient moisturizing effect and cannot improve the problems of loose lips and fine lines on the lips. In addition, some products may contain irritating ingredients, which can easily burden the lip skin and aggravate the lip problems. Summary of the invention

[0005] In order to improve the lip peeling and chapped problems, reduce lip lines, and improve the lip skin barrier and anti-irritation ability, the present application provides a lip skin protectant and a preparation method thereof.

[0006] In the first aspect, the present application provides a lip skin protectant, which adopts the following technical solution: A lip skin protectant, wherein the raw materials include, by mass percentage, 36-75% of squalane, 10-30% of natural plant oil, 7.3-21% of active substance, 2-7% of glyceryl behenate, 1-6% of lecithin, 1-6% of polyglyceryl-4 isostearate and 0.1-2% of antioxidant; The active substances include 7-15% of phytosterols, 0.1-4% of ceramides and 0.2-2% of palmitoyl active peptides.

[0007] By adopting the above technical solutions, palmitoyl active peptide can effectively promote the metabolism of skin cells, stimulate the lip skin fibroblasts to produce collagen and elastin, and promote the synthesis of substances such as polysaccharides in the intercellular matrix, thereby strengthening the cell structure, playing a role in cell repair, and preventing skin structure collapse.

[0008] Phytosterols have a proliferative effect on keratin and fibroblasts. When mixed with palmitoyl active peptides as active substances, they can further promote the synthesis of collagen and elastin, improve the elasticity and firmness of the lip skin, effectively resist aging, slow down the aging process of the lip skin, and effectively fade lip lines.

[0009] Ceramide is the main component of the intercellular matrix and is involved in the formation of the epidermal barrier function. It plays an important role in signal transduction, cell proliferation and differentiation, and immune regulation. It can effectively repair the skin barrier, improve the skin barrier and anti-irritation capabilities, and help fight aging.

[0010] Ceramide is a natural moisturizing factor, while palmitoyl peptide can promote the production of natural moisturizing factors in skin cells. As an active substance, phytosterols also have antioxidant and immune-regulating functions, which can protect the skin from free radical damage, help regulate the skin's immune response to external stimuli, help maintain and repair the skin barrier, reduce water loss, and effectively maintain the skin's natural moisturizing factor. The combination of the three as active substances can significantly improve the skin's moisturizing ability, help maintain the skin's moisture balance, prevent water loss, and protect the skin from the external environment, effectively improving the peeling and cracking problems of the lip skin.

[0011] Polyglyceryl-4 isostearate and lecithin, as emulsifiers, can form a stable and effective liposome carrier system, in which the active ingredients can be encapsulated and their stability and permeability can be improved, thereby promoting the active ingredients to act through the skin barrier.

[0012] Glyceryl behenate is a long-chain fatty acid glyceride that has good affinity with lipids on the surface of the lip skin and can be used as a transdermal enhancer to form a flexible liposome carrier system with polyglyceryl-4 isostearate and lecithin. Long-chain fatty acids can entangle with each other to form a larger spatial structure that can accommodate more active ingredients, making the carrier system more compatible and encapsulating for the active ingredients, promoting the carrier system's delivery of active ingredients, and improving the permeability of active ingredients to the lip skin.

[0013] Optionally, the phytosterol is any one of β-sitosterol, β-carotene, ergosterol and stigmasterol.

[0014] Optionally, the phytosterol is β-sitosterol.

[0015] By adopting the above technical scheme, the above types of plant sterols have good safety. When used in the preparation of cosmetics, they can effectively promote the formation of collagen in skin cells, maintain the elasticity and firmness of the lip skin, and fade lip lines. At the same time, they can enhance the lip skin barrier and anti-irritation ability, reduce the sensitivity of the lip skin, and improve the problems of lip skin peeling and chapped skin.

[0016] Optionally, the ceramide is any one of ceramide NS and ceramide NP, or a combination of both.

[0017] By adopting the above technical scheme, ceramide is an important component of the skin barrier. The above ceramide is used to prepare lip skin protectants, which can enhance the moisturizing ability of the lip skin, improve the skin barrier function, and reduce the dryness and peeling of the lip skin.

[0018] Optionally, the palmitoyl active peptide is any one or more combinations of palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, palmitoyl tripeptide-5, palmitoyl pentapeptide-3, palmitoyl dipeptide-7, palmitoyl hexapeptide-12 and palmitoyl tripeptide-38.

[0019] Optionally, the palmitoyl active peptides are palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7.

[0020] By adopting the above technical solutions, these palmitoyl active peptides can effectively promote the synthesis of collagen and elastin in the lip skin, fade lip lines, and improve the elasticity and firmness of the lip skin.

[0021] Optionally, the natural plant oil comprises 1-5% of candelilla wax, 8-15% of avocado butter and 1-10% of black cumin seed oil.

[0022] By adopting the above technical scheme, candelilla wax, avocado butter and black cumin seed oil are all natural plant oils, which can form a protective layer on the surface of the lip skin, effectively lock in moisture and moisturize the lip skin, and provide long-lasting moisturizing effect. Moreover, these components are highly safe and mild in performance, and will not burden the lip skin.

[0023] As a natural wax, candelilla wax can also increase the stability and structure of the lip skin protectant, improve the application feel and comfort of the lip skin protectant, prevent the lip skin protectant from breaking or melting, and make it smoother and easier to apply.

[0024] Avocado butter and black cumin seed oil are rich in beneficial fatty acids, vitamins and antioxidants, which can deeply nourish the lip skin. They also have anti-inflammatory and soothing effects. They are suitable for sensitive or damaged lip skin, can help repair damaged skin cells, reduce lip inflammation and promote skin repair.

[0025] Optionally, the antioxidant is a fat-soluble antioxidant, which is a combination of tocopherol and coenzyme Q10 or a combination of tea polyphenols and coenzyme Q10.

[0026] By adopting the above technical solution, tocopherol, coenzyme Q10 and tea polyphenols are all fat-soluble antioxidants with strong antioxidant capacity, which can form a stable and good anti-inflammatory system in the lip skin protector. When used, it can help the lip skin maintain a good anti-inflammatory ecology, protect the lip skin from damage by free radicals, improve the lip skin barrier and anti-irritation ability, prevent lip skin aging, maintain lip skin elasticity, improve the lip water-locking ability, help improve lip peeling and chapped problems, and fade lip lines.

[0027] In a second aspect, the present application provides a method for preparing a lip skin protectant, using the following technical solution: A method for preparing a lip skin protectant comprises the following steps: Prepare the materials according to the raw material ratio, evenly disperse the phytosterol in ethanol to form an active solution; evenly mix glyceryl behenate, lecithin and polyglyceryl-4 isostearate and then mix with water to form a carrier system; The active solution is added to the carrier system, and the organic solvent is removed by rotary evaporation after uniform stirring, and a suspension is formed and then ultrasonically crushed to obtain a nano-active dispersion; The nano-active dispersion is subjected to vacuum freeze drying at -70 to -90°C for 72 to 96 hours, and the nano-active phytosterol freeze-dried powder is obtained after crushing; Mix squalane and natural plant oil, heat to 85-95°C until melted and stir evenly, then cool to 65-70°C, add nano-active phytosterol freeze-dried powder, ceramide, palmitoyl active peptide and antioxidant, stir homogenously at a speed of 500-1000rmp for 20-30 minutes, vacuum degassing, canning, cooling and demoulding to obtain the lip skin protector.

[0028] Optionally, the lip skin protectant is in an ointment form.

[0029] By adopting the above technical solution, the poor solubility of phytosterols leads to low bioavailability and is not easily absorbed by the human body. Through nanotechnology and vacuum freeze-drying technology, phytosterols are first encapsulated in a liposome carrier system formed by polyglycerol-4 isostearate, lecithin and glyceryl behenate to form a freeze-dried powder, which is then used to prepare a lip skin protectant, which can significantly improve the water solubility and stability of phytosterols. This effectively increases the contact area between phytosterols and the lip skin or mucous membrane, which is crucial for the uniform distribution and effective release of phytosterol active ingredients after entering the skin.

[0030] In summary, this application has the following beneficial effects: 1. This application uses a mixture of plant sterols, ceramides and palmitoyl active peptides as active substances, which can significantly enhance the moisturizing and water-locking ability of the lip skin, maintain the moisture balance of the lip skin, effectively improve the skin barrier and anti-irritation ability, and improve the peeling and chapped problems of the lip skin; palmitoyl active peptides and plant sterols can synergistically effectively stimulate the lip skin cells to produce collagen and elastin, prevent skin structure collapse, improve the elasticity and firmness of the lip skin, and fade lip lines.

[0031] 2. In the present application, polyglyceryl-4 isostearate and lecithin are used as emulsifiers, and glyceryl behenate is used as a transdermal enhancer to form a liposome carrier system, which effectively promotes the penetration of the active ingredients through the skin barrier, plays a role in the delivery of the active ingredients, and improves the permeability of the active ingredients to the lip skin.

[0032] 3. This application uses candelilla wax, avocado butter and black cumin seed oil as natural plant oils, which can deeply nourish the lip skin, form a stable protective layer on the surface of the lip skin, effectively lock in moisture and moisturize the lip skin, provide long-lasting moisturizing effect, and help the lip skin improve peeling and cracking; it also has anti-inflammatory and soothing effects, is suitable for sensitive or damaged lip skin, can help repair damaged skin cells, reduce lip inflammation, and promote skin repair.

[0033] 4. The method of the present application first encapsulates the phytosterols through a liposome carrier system formed by polyglycerol-4 isostearate, lecithin and glyceryl behenate to form a freeze-dried powder and then prepares a lip skin protectant. This can significantly improve the problem of poor solubility and absorbability of phytosterols, and effectively promote the uniform distribution and effective release of phytosterols after entering the skin. DETAILED DESCRIPTION

[0034] The following examples further illustrate the present application in detail.

[0035] raw material Unless otherwise specified, the raw materials used in the examples and comparative examples of this application are all commercially available products, specifically: Squalane, selected from Huapeptide Biotechnology, ht-0904-01,; Candelilla wax, selected from Cangzhou Fenrong Beeswax Co., Ltd., Candelilla wax 032; Avocado butter, selected from BASF, HPLC ≥ 99%; Black cumin seed oil, selected from Jiangxi Xinsen Natural Plant Oil Co., Ltd., black cumin seed oil; Glyceryl behenate, selected from Nissin Oilliu Group, CAS: 215322-01-3; Lecithin, analytical grade, HPLC ≥ 98%; Polyglycerol-4 isostearate, selected from Hubei Zhenbo, CAS: 91824-88-3; Palmitoyl tripeptide-1, palmitoyl tetrapeptide-7 and acetyl hexapeptide-8 are all selected from Meiyi Biotechnology, cosmetic grade; Ceramide NS and ceramide NP, both selected from Xi'an Tianzhilu Biotechnology, HPLC ≥ 98%; Tocopherol, selected from BASF, Germany, dl-a-tocopherol acetate; Coenzyme Q10, selected from Lvteng Biotechnology, LTFMQ10; Tea polyphenols, selected from Wenyun Biotechnology, WY-0610-613. Example

[0036] Example 1 A lip skin protectant, wherein the raw materials and amounts are shown in Table 1, wherein the phytosterol is β-sitosterol, the ceramide is ceramide NS and ceramide NP in a mass ratio of 1:1; the palmitoyl active peptide is palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7 in a mass ratio of 1:1; and the antioxidant is tocopherol and coenzyme Q10 in a mass ratio of 1:1.

[0037] Table 1 The preparation method of the above-mentioned lip skin protective agent comprises the following steps: S1: Prepare the materials according to the raw material ratio, evenly disperse the phytosterols in ethanol, and sonicate until completely dissolved to form an active solution; S2: Glyceryl behenate, lecithin and polyglycerol-4 isostearate are uniformly mixed and then mixed with deionized water in a mass ratio of 1:4 to form a carrier system; S3: adding the active solution to the carrier system, stirring evenly, and then performing rotary evaporation at 70°C and 80MPa to remove the organic solvent, and then performing ultrasonic crushing for 30 minutes to form a suspension to obtain a nano-active dispersion; S4: freeze-drying the nano-active dispersion at -70°C for 96 hours in a vacuum manner, and crushing to obtain nano-active phytosterol freeze-dried powder; S5: Mix squalane and natural plant oils, heat to 85°C until completely melted and stir evenly, then cool to 70°C, add nano-active plant sterol freeze-dried powder, ceramide, palmitoyl active peptide and antioxidant, and mix at a speed of 1000 rpm for 30 minutes. After vacuum degassing, canning, cooling and demolding, a lip skin protectant in ointment form is obtained.

[0038] Example 2 A lip skin protectant, which is different from Example 1 in that the raw materials and amounts are as shown in Table 1, wherein the phytosterol is β-carotene; the antioxidant is tea polyphenols and coenzyme Q10 in a mass ratio of 1:1; and the ceramide is ceramide NP. The preparation method of the lip skin protectant comprises the following steps: S1: Prepare the materials according to the raw material ratio, evenly disperse the phytosterols in ethanol, and sonicate until completely dissolved to form an active solution; S2: Glyceryl behenate, lecithin and polyglycerol-4 isostearate are uniformly mixed and then mixed with deionized water in a mass ratio of 1:4 to form a carrier system; S3: adding the active solution to the carrier system, stirring evenly, and then performing rotary evaporation at 70°C and 80MPa to remove the organic solvent, and then performing ultrasonic crushing for 30 minutes to form a suspension to obtain a nano-active dispersion; S4: vacuum freeze-drying the nano-active dispersion at -82°C for 85 hours, and crushing to obtain nano-active phytosterol freeze-dried powder; S5: Mix squalane and natural plant oils, heat to 90°C until completely melted and stir evenly, then cool to 70°C, add nano-active plant sterol freeze-dried powder, ceramide, palmitoyl active peptide and antioxidant, and mix at a speed of 500 rpm for 30 minutes. After vacuum degassing, canning, cooling and demolding, a lip skin protectant in ointment form is obtained.

[0039] Example 3 A lip skin protectant, which is different from Example 1 in that the raw materials and amounts are as shown in Table 1, wherein the phytosterol is ergosterol, and the ceramide is ceramide NS and ceramide NP in a mass ratio of 1:2; The preparation method of the above-mentioned lip skin protective agent comprises the following steps: S1: Prepare the materials according to the raw material ratio, evenly disperse the phytosterols in ethanol, and sonicate until completely dissolved to form an active solution; S2: Glyceryl behenate, lecithin and polyglycerol-4 isostearate are uniformly mixed and then mixed with deionized water in a mass ratio of 1:4 to form a carrier system; S3: adding the active solution to the carrier system, stirring evenly, and then performing rotary evaporation at 70°C and 80MPa to remove the organic solvent, and then performing ultrasonic crushing for 30 minutes to form a suspension to obtain a nano-active dispersion; S4: freeze-drying the nano-active dispersion at -90°C for 72 hours in a vacuum, and crushing to obtain nano-active phytosterol freeze-dried powder; S5: Mix squalane and natural plant oils, heat to 95°C until completely melted and stir evenly, then cool to 70°C, add nano-active plant sterol freeze-dried powder, ceramide, palmitoyl active peptide and antioxidant, and mix at a speed of 1000 rpm for 30 minutes. After vacuum degassing, canning, cooling and demolding, a lip skin protectant in ointment form is obtained.

[0040] Example 4 A lip skin protectant, which is different from Example 1 in that the raw materials and amounts are as shown in Table 1, wherein the phytosterol is stigmasterol; the ceramide is ceramide NS; The preparation method of the above-mentioned lip skin protective agent comprises the following steps: S1: Prepare the materials according to the raw material ratio, evenly disperse the phytosterols in ethanol, and sonicate until completely dissolved to form an active solution; S2: Glyceryl behenate, lecithin and polyglycerol-4 isostearate are uniformly mixed and then mixed with deionized water in a mass ratio of 1:4 to form a carrier system; S3: adding the active solution to the carrier system, stirring evenly, and then performing rotary evaporation at 70°C and 80MPa to remove the organic solvent, and then performing ultrasonic crushing for 30 minutes to form a suspension to obtain a nano-active dispersion; S4: freeze-drying the nano-active dispersion at -80°C for 90 hours in a vacuum, and crushing to obtain nano-active phytosterol freeze-dried powder; S5: Mix squalane and natural plant oils, heat to 85°C until completely melted and stir evenly, then cool to 65°C, add nano-active plant sterol freeze-dried powder, ceramide, palmitoyl active peptide and antioxidant, and mix at a speed of 500 rpm for 20 minutes. After vacuum degassing, canning, cooling and demoulding, a lip skin protectant in ointment form is obtained.

[0041] Embodiment 5-6 A lip skin protectant, which is different from Example 1 in that the raw materials and amounts are as shown in Table 1, and the other steps are the same as those in Example 1.

[0042] Example 7 A lip skin protectant, which is different from Example 1 in that the antioxidant in the raw material is tocopherol, and the other steps are the same as those in Example 1.

[0043] Example 8 A lip skin protectant, which is different from Example 1 in that the antioxidant in the raw material is tea polyphenols, and the other steps are the same as Example 1.

[0044] Example 9 A lip skin protectant, which is different from Example 1 in that the antioxidant in the raw material is coenzyme Q10, and the other steps are the same as Example 1.

[0045] Comparative Example Comparative Example 1 A lip skin protectant, which differs from Example 1 in that the raw material active substance does not contain phytosterols, the original phytosterols in the raw material are replaced by an equal mass of polyols, 1,2-propylene glycol, and the other steps are the same as Example 1.

[0046] Comparative Example 2 A lip skin protectant, which is different from Example 1 in that the raw material active substance does not contain palmitoyl polypeptide, the original palmitoyl polypeptide in the raw material is replaced by an equal mass of squalane, and the other steps are the same as Example 1.

[0047] Comparative Example 3 A lip skin protectant, which differs from Example 1 in that the palmitoyl polypeptide in the raw active substance is replaced by acetyl hexapeptide-8 of equal mass, and the other steps are the same as Example 1.

[0048] Comparative Example 4 A lip skin protectant, which differs from Example 1 in that palmitoyl polypeptide and phytosterol in the raw material active substances are replaced by polyols of equal mass, 1,2-propylene glycol, and other steps are the same as Example 1.

[0049] Comparative Example 5 A lip skin protectant, which differs from Example 1 in that glyceryl behenate in the raw active substance is replaced by squalane of equal mass, and the other steps are the same as those of Example 1.

[0050] Comparative Example 6 A lip skin protectant, which differs from Example 1 in that a method for preparing the lip skin protectant comprises the following steps: mixing squalane and natural plant oils, heating to 85°C until completely melted and stirring evenly, then cooling to 70°C, adding glyceryl behenate, lecithin and polyglycerol-4 isostearate and continuing to stir evenly, then adding phytosterols, ceramide, palmitoyl active peptide and antioxidant, homogenizing and stirring at a speed of 1000 rpm for 30 minutes, and obtaining a lip skin protectant in an ointment form after vacuum degassing, canning, cooling and demolding.

[0051] Performance testing The lip skin protectants of Examples 1-9 and Comparative Examples 1-6 were subjected to the following relevant performance testing tests.

[0052] Test Example 1: Hygiene Index Testing The lip skin protectant obtained in Example 1-9 and Comparative Example 1-6 was tested for hygienic indicators such as microorganisms and heavy metals. The specific project types and technical indicators are shown in Table 2.

[0053] According to the corresponding requirements in the "Technical Specification for Safety of Cosmetics" (2015 edition), the results show that all test indicators of the lip skin protectant obtained in the embodiments and comparative examples of the present application meet the requirements.

[0054] Table 2 Test Example 2: Security Test The lip skin protectants obtained in Examples 1-9 and Comparative Examples 1-6 were subjected to human skin patch tests to test their safety. 65 subjects aged 20-50 were selected as test subjects and randomly divided into 13 groups, with 5 subjects in each group.

[0055] Test method: Use a third-party testing agency to test safety, and select an area not exceeding 50mm 2 , a suitable patch tester with a depth of about 1 mm, add about 0.02-0.025 ml (g) of the test substance (lip skin protectant obtained in Examples 1-9 and Comparative Examples 1-6) into the patch tester by a closed patch test method, and stick the patch tester on the curved side of the forearm of the test subject. After 24 hours, the test substance is removed, and the skin reaction is observed 0.5 hours, 2 hours and 24 hours after removal, and the results are recorded according to the skin reaction grading standards in the "Technical Regulations on Safety of Cosmetics 2015", and the experimental results are recorded in Table 3.

[0056] Skin reaction grading standards: Grade 0: negative reaction; Grade 1: Suspicious reaction; only slight erythema; Grade 2: weak positive reaction (erythema reaction); erythema, infiltration, edema, and papules may be present; Grade 3: Strong positive reaction (herpes reaction); erythema, infiltration, edema, papules, herpes; the reaction may extend beyond the test area; Grade 4: Very strong reaction (confluent herpes reaction); obvious erythema, severe infiltration, edema, confluent herpes, and the reaction exceeds the test area.

[0057] Table 3 According to the data results in Table 3, it can be seen that the lip skin protectants obtained in Examples 1-9 of the present application and Comparative Examples 1-6 scored 0 at 0.5h, 2h and 24h, and the subjects did not experience adverse skin reactions, indicating that a lip skin protectant of the present application will not have a negative impact on skin safety.

[0058] Test Example 3 Penetration Performance Test Using a 3D full-thickness skin model as a carrier, referring to GB / T27818-2011 standard for in vitro test methods for skin absorption of chemicals, a Franz vertical diffusion cell was used to test the penetration-promoting ability of active substances in the lip skin protectants obtained in Examples 1-9 and Comparative Examples 1-6.

[0059] The 2h and 4h active substance diffusion rates of the lip skin protectant were calculated. Each test was performed 3 times, and the average value of the 3 tests was taken as the final result and recorded in Table 4.

[0060] 2h / 4h diffusion rate = sample content in the receiving cell after 2h / 4h / initial content of the sample in the supply cell × 100%.

[0061] Table 4 According to the performance test results in Table 4, it can be seen that polyglyceryl-4 isostearate and lecithin, as emulsifiers, form a delivery system for active ingredients in the lip skin protector, and glyceryl behenate can be used as a transdermal enhancer to form a liposome carrier system with polyglyceryl-4 isostearate and lecithin. This significantly promotes the active substances to penetrate through the skin barrier and penetrate deep into the skin, promotes the delivery of active substances, and improves the lip skin permeability of active substances.

[0062] The phytosterols are first encapsulated in a liposome carrier system formed by polyglycerol-4 isostearate, lecithin and glyceryl behenate to form a freeze-dried powder, and then used to prepare a lip skin protectant. This can significantly improve the poor permeability and solubility of phytosterols, effectively promote the uniform distribution and effective release of phytosterols after entering the skin, and significantly improve the skin permeability of active substances.

[0063] In addition, compared with the combination of tocopherol and coenzyme Q10 or the combination of tea polyphenols and coenzyme Q10, tocopherol, coenzyme Q10 and tea polyphenols used alone as antioxidants are more beneficial in helping the lip skin maintain a good anti-inflammatory ecology, protecting the lip skin from damage by free radicals, improving the lip skin barrier and anti-irritation ability, enhancing the lips' ability to lock in moisture, and helping to improve lip peeling and chapped problems.

[0064] Test Example 4: Lip Line Lightening Effect Test Subjects: 65 volunteers aged 20-50 years old with lips of similar thinness and dryness were selected as test subjects and randomly divided into 13 groups, with 5 people in each group.

[0065] Usage: 13 groups of test subjects applied the lip skin protectants obtained from Examples 1-9 and Comparative Examples 1-6 respectively, 3 times a day in the morning, noon and evening, for 30 consecutive days.

[0066] Test method: Use a skin microscope and an active skin surface analysis system (VC98, USB, CK Company, Germany) to test the lip skin smoothness (SESM) and skin wrinkles (SEW) of the test subjects, and record the test results of the test subjects, where SESM represents skin smoothness and SEW represents skin wrinkles. The smaller the values ​​of the two, the narrower the lip wrinkles are, and the better the smoothness and firmness of the lip skin.

[0067] The lip skin smoothness improvement rate and wrinkle improvement rate of each group of test subjects were calculated, and the average value of the 5 test subjects in each group was calculated as the final result and recorded in Table 5.

[0068] The calculation formula for the improvement rate of lip skin smoothness is: {(the smoothness characteristic number of the lips of the same test subject before using the lip skin protectant-the smoothness characteristic number of the lips of the test subject after using the lip skin protectant for 30 days) / the smoothness characteristic number of the lips of the same test subject before using the lip skin protectant}×100%; The calculation formula for the skin wrinkle improvement rate is: {(the number of wrinkle features on the lips of the same test subject before using the lip skin protectant - the number of wrinkle features on the lips of the test subject 30 days after using the lip skin protectant) / the number of wrinkle features on the lips of the same test subject before using the lip skin protectant}×100%.

[0069] Table 5 Group Lip skin smoothness improvement rate / % Lip wrinkle improvement rate / % Example 1 51.3 54.8 Example 2 52.7 56.2 Example 3 49.8 52.5 Example 4 50.5 53.9 Example 5 50.8 54.0 Example 6 51.4 54.1 Example 7 48.3 52.5 Example 8 47.8 52.1 Example 9 48.2 52.0 Comparative Example 1 31.6 36.7 Comparative Example 2 20.7 21.0 Comparative Example 3 43.2 47.6 Comparative Example 4 12.9 14.1 Comparative Example 5 42.5 48.3 Comparative Example 6 37.4 42.5 According to the performance test results in Table 5, it can be seen that the present application uses a mixture of plant sterols, ceramides and palmitoyl active peptides as active substances, which can effectively improve the skin barrier and anti-irritation capabilities, and improve the peeling and chapped skin problems of the lips.

[0070] Palmitoyl active peptides and phytosterols can effectively stimulate the production of collagen and elastin in lip skin cells, prevent skin structure collapse, improve the elasticity and firmness of lip skin, and reduce lip lines. Compared with other active peptides, palmitoyl active peptides have more significant effects in reducing lip lines and improving lip skin firmness. They can effectively resist aging and improve lip aging problems.

[0071] The phytosterols are first encapsulated in a liposome carrier system formed by polyglycerol-4 isostearate, lecithin and glyceryl behenate to form a freeze-dried powder, and then the lip skin protectant is prepared. This can significantly improve the problem of poor solubility and absorbability of phytosterols, and effectively promote the uniform distribution, effective release and action of phytosterols after entering the skin.

[0072] Test Example 5: Improvement of chapped lips The test subjects were selected and the lip skin protectant was used as in Test Example 4.

[0073] Test method: Use a skin moisture loss tester (Tewameter TM Nano) to test the transepidermal water loss rate of the test subject's lip skin, and record the test results of the test subject. The smaller the measured value, the smaller the transepidermal water loss per unit time and unit cross-sectional area, indicating that the lip skin barrier function is better, the water loss is less, and the lip skin is more moist; use the skin water content (CM 825) to test the moisture content of the test subject's lip skin.

[0074] The transepidermal water loss rate of the lip skin and the improvement rate of the lip skin moisture content of each group of test subjects were calculated, and the average value of the 5 test subjects in each group was calculated as the final result and recorded in Table 6.

[0075] The calculation formula of the transepidermal water loss rate of the lip skin is: {(transepidermal water loss of the lips of the same test subject before using the lip skin protectant - transepidermal water loss of the lips of the test subject after using the lip skin protectant for 30 days) / transepidermal water loss of the lips of the test subject before using the lip skin protectant}×100%; The calculation formula for the improvement rate of the lip skin moisture content is: the moisture content of the test subject's lips after using the lip skin protectant for 30 days / the moisture content of the lips of the same test subject before using the lip skin protectant×100%.

[0076] Table 6 According to the performance test results in Table 6, it can be seen that the active substance ceramide of the present application is a natural moisturizing factor, and palmitoyl peptide can promote the production of natural moisturizing factors in skin cells. Phytosterols as active substances also have antioxidant and immune regulation functions, which help to maintain and repair the skin barrier, reduce water loss, and effectively maintain the skin's natural moisturizing factor. The mixture of the three as active substances can significantly improve the skin's ability to lock in moisture and moisturize, help maintain the moisture balance of the lip skin, prevent water loss, and effectively improve the peeling and cracking problems of the lip skin.

[0077] The liposome carrier system formed by polyglyceryl-4 isostearate, lecithin and glyceryl behenate significantly promotes the permeability of active substances, which helps the active substances to break through the skin barrier and transmit inward, ensuring the effective release and exertion of the active substances.

[0078] The lip skin protectant is prepared by encapsulating phytosterols into freeze-dried powder through a liposome carrier system, which significantly improves the poor solubility and absorbability of phytosterols. When applied, it helps to provide lasting moisturizing and hydrating effects for the lip skin, improve the lip skin barrier and anti-irritation ability, reduce the sensitivity of the lip skin, and improve the lip skin peeling and cracking problems.

[0079] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed. However, as long as it is within the scope of the claims of the present application, it shall be protected by the patent law.

Claims

1. A lip skin protectant, characterized in that: According to the percentage by mass, the raw materials include 36-75% squalane, 10-30% natural vegetable oil, 7.3-21% active substance, 2-7% glyceryl behenate, 1-6% lecithin, 1-6% polyglyceryl-4 isostearate and 0.1-2% antioxidant; The active substances include 7-15% of phytosterols, 0.1-4% of ceramides and 0.2-2% of palmitoyl active peptides.

2. The lip skin protective agent according to claim 1, characterized in that: The phytosterol is any one of β-sitosterol, β-carotene, ergosterol and stigmasterol.

3. The lip skin protective agent according to claim 1, characterized in that: The ceramide is any one of ceramide NS and ceramide NP or a combination of both.

4. The lip skin protective agent according to claim 1, characterized in that: The palmitoyl active peptide is any one or more combinations of palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, palmitoyl tripeptide-5, palmitoyl pentapeptide-3, palmitoyl dipeptide-7, palmitoyl hexapeptide-12 and palmitoyl tripeptide-38.

5. The lip skin protective agent according to claim 1, characterized in that: The natural plant oil comprises 1-5% of candelilla wax, 8-15% of avocado tree butter and 1-10% of black cumin seed oil.

6. The lip skin protective agent according to claim 1, characterized in that: The antioxidant is a fat-soluble antioxidant, which is a combination of tocopherol and coenzyme Q10 or a combination of tea polyphenols and coenzyme Q10.

7. The method for preparing a lip skin protectant according to any one of claims 1 to 6, characterized in that: The following steps are involved: Prepare the materials according to the raw material ratio, evenly disperse the phytosterol in ethanol to form an active solution; evenly mix glyceryl behenate, lecithin and polyglyceryl-4 isostearate and then mix with water to form a carrier system; The active solution is added to the carrier system, and the organic solvent is removed by rotary evaporation after uniform stirring, and a suspension is formed and then ultrasonically crushed to obtain a nano-active dispersion; The nano-active dispersion is subjected to vacuum freeze drying at -70 to -90°C for 72 to 96 hours, and the nano-active phytosterol freeze-dried powder is obtained after crushing; Mix squalane and natural plant oil, heat to 85-95°C until melted and stir evenly, then cool to 65-70°C, add nano-active phytosterol freeze-dried powder, ceramide, palmitoyl active peptide and antioxidant, stir homogenously at a speed of 500-1000rmp for 20-30 minutes, vacuum degassing, canning, cooling and demoulding to obtain the lip skin protector.

8. The method for preparing the lip skin protective agent according to claim 7, characterized in that: The lip skin protectant is in the form of an ointment.

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