Rhodiola rosea pectic polysaccharide and application thereof

By preparing Rhodiola rosea pectin polysaccharides with specific structures and compositions, the problem of unclear application of Rhodiola rosea pectin polysaccharides in non-alcoholic fatty liver disease was solved, and the effect of significantly improving hepatic steatosis and hepatocellular damage was achieved.

CN119684486APending Publication Date: 2025-03-25CHONGQING UNIV OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Application Number
CN202411971779.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-30
Publication Date
2025-03-25

AI Technical Summary

Technical Problem

The role of Rhodiola rosea pectin polysaccharide in improving non-alcoholic fatty liver disease has not been reported in the existing technology, and its specific mechanism of action and active ingredients are unclear.

Method used

A Rhodiola rosea pectin polysaccharide is provided, which is prepared by a specific sugar chain composition and preparation method, including extraction, protein removal, ethanol precipitation and chromatography purification, to produce a Rhodiola rosea pectin polysaccharide with a galacturonic acid content of up to 80% or more, for the purpose of improving non-alcoholic fatty liver disease.

Benefits of technology

It significantly improves high-fructose-induced hepatic steatosis in mice, reduces the accumulation of fatty acids in the liver, inhibits the release of inflammatory factors, alleviates hepatocellular damage, and relieves non-alcoholic fatty liver disease.

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Abstract

The invention relates to rhodiola rosea pectic polysaccharide and application thereof.The sugar chain structure of the rhodiola rosea pectic polysaccharide is shown in the formula I. In the formula I, Glc is a glucose residue, GalA is a galacturonic acid residue, Ara is an arabinofuranose residue, and MeO is a methoxyl group; wherein m is an integer selected from 10 to 40; n is an integer selected from 1 to 50. The rhodiola rosea pectic polysaccharide can significantly improve mouse liver fatty degeneration induced by high fructose and relieve liver injury, and has a good application prospect in improvement of non-alcoholic fatty liver.
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Citation Information

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