Ganoderma lucidum polysaccharide-astragalus gum-bacterial cellulose medical catheter and preparation method thereof

Abstract

The invention discloses a ganoderan-astragalus gum-bacterial cellulose medical catheter. Each 100ml of medical catheter preparation solution is prepared from the following components: 1 to 10g of ganoderan, 1 to 10g of bacterial cellulose, 2 to 30mL of 10 percent astragalus gum solution and 10 to 100mL of aqueous solution. The raw materials in the formula are wide in source and low in price, and have the surface adsorption, interception and grafting functions of medical polymer materials. The medical catheter prepared according to the formula of the invention is non-toxic and immunological inert, and the biocompatibility of a medical polymer material in contact with blood is improved. According to the formula, the catheter prepared through the mold has a rich three-dimensional structure, a necessary way can be provided for conveying nutrient substances needed in the growth process of nerve cells, and a necessary induction effect and a necessary growth space are provided for growth of the nerve cells.

Description

Technical Field

[0001] The present application belongs to the technical field of medical materials, and specifically relates to a Ganoderma lucidum polysaccharide-astragalus gum-bacterial cellulose medical catheter and a preparation method thereof. Background Art

[0002] Medical catheters have long been a necessity in medical practice, and usually need to be implanted in the human body for invasive diagnosis and treatment, such as intravascular catheters, coronary intervention guide catheters, central venous catheters, urinary catheters used in urinary tract treatment, endotracheal intubation, and peripheral nerve catheters, which are all necessary and frequently performed medical practices in general medical operations. Peripheral nerve defects caused by trauma are relatively common in clinical practice, but when medium and long-distance nerve defects cannot be compensated by end-to-end suturing, catheters are needed to bridge and repair. In addition to the above-mentioned traditional medical catheters, with the rapid advancement of medical technology, multi-lumen and composite-tube catheters have also been produced one after another, and the time they are retained in the body has increased relatively. They have also become an important tool for current medical practices such as blood flow monitoring, infusion, hemodialysis, drug administration, and intravenous nutrition support, indicating a sharp increase in the use and demand for medical catheters.

[0003] Ganoderma lucidum polysaccharide is one of the most effective ingredients of Ganoderma lucidum. Ganoderma lucidum polysaccharide has many pharmacological activities: it can improve the body's immunity, accelerate blood microcirculation, improve blood oxygen supply capacity, reduce the body's ineffective oxygen consumption in a static state, eliminate free radicals in the body, improve the body's cell membrane closure, anti-radiation, improve the liver, bone marrow, blood synthesis of DNA, RNA, protein ability, prolong life, etc. Because Ganoderma lucidum polysaccharide has unique physiological activity and clinical effects, and is safe and non-toxic, it can be widely used in the pharmaceutical, food and cosmetics industries. In addition, Ganoderma lucidum polysaccharide can also inhibit the release of allergic reaction mediators, thereby blocking the occurrence of non-specific reactions, and thus inhibiting the recurrence and metastasis of cancer cells after surgery. Ganoderma lucidum polysaccharide preparations that have been put into use include tablets, injections, granules, oral liquids, syrups and wine preparations, all of which have achieved certain clinical efficacy. Ganoderma lucidum polysaccharide can be made into health foods as a functional factor, and can also be added to beverages, cakes, and oral liquids as a food additive, which has greatly enriched the food market. Because Ganoderma lucidum polysaccharide has the effect of resisting free radicals, it can be used in cosmetics to delay aging.

[0004] Astragalus gum is one of the most important natural biopolymer materials. It is cheap and easy to obtain, has good biocompatibility and degradability, and has been widely used in food, medicine and chemical industries. This product has film-forming and gelling properties, and can be used as a blocker for sustained-release preparations to regulate the release of drugs. This characteristic also makes Astragalus gum have better drug-loading performance as a medical stent material.

[0005] Bacterial cellulose is an unbranched polymer with the same β-1,4-linked pyranose glucose residues as plant cellulose. It is formed by nanofibers to form nanofiber bundles, which are then interwoven to form a fine mesh structure. It has the characteristics of ultrafine fibers, high chemical purity, high crystallinity, high water retention, high air permeability, non-toxicity, adaptability, good mechanical properties, biocompatibility and biodegradability. It is recognized as a new type of biological material with excellent performance and has been widely recognized and applied in the fields of tissue engineering, food, papermaking, chemical industry, fine spinning, medicine, etc. In recent years, with the deepening of research and understanding of bacterial cellulose, its application range has become more and more extensive. The unique ultrafine nanofiber porous structure of bacterial cellulose is considered to be a natural biomedical material with superior performance. Therefore, biomedical scaffolds using bacterial cellulose as a material are becoming more and more competitive. Summary of the invention

[0006] The present application provides a Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter and a preparation method thereof to solve the above-mentioned technical problems.

[0007] In order to solve the above technical problems, a technical solution adopted in the present application is: a Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter, wherein each 100 ml of the medical catheter preparation solution contains the following components: 1-10 g of Ganoderma lucidum polysaccharide, 1-10 g of bacterial cellulose, 2-30 ml of 10% tragacanth gum solution, and 10-100 ml of aqueous solution.

[0008] Furthermore, each 100 ml of the medical catheter preparation solution contains the following components: 3-7 g of ganoderma lucidum polysaccharide, 3-8 g of bacterial cellulose, 10-25 ml of 10% tragacanth gum solution, and 20-80 ml of aqueous solution.

[0009] Furthermore, each 100 ml of the medical catheter preparation solution contains the following components: 5 g of Ganoderma lucidum polysaccharide, 68 g of bacterial cellulose, 20 ml of 10% tragacanth gum solution, and 50 ml of aqueous solution.

[0010] Furthermore, the mass percentage of tragacanth gum and pure water in the 10% tragacanth gum solution is 1:9.

[0011] Furthermore, the medical catheter is a circular tube mesh support with a hollow center, and a mixed solution of Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose is loaded on the support.

[0012] Another technical solution adopted in the present application is: a method for preparing a Ganoderma lucidum polysaccharide-astragalus gum-bacterial cellulose medical catheter, comprising:

[0013] S1. The bacterial cellulose was soaked in 1% NaOH, heat treated at 60°C for 1h, and then washed with distilled water until neutral; the bacterial cellulose was then shredded and added to 10-100mL of aqueous solution, and the bacterial cellulose was sheared at high speed for 15min (speed 12kr / min) by a high shear emulsifier to obtain a bacterial cellulose slurry;

[0014] S2. slowly pouring the tragacanth gum solution into the bacterial cellulose slurry, stirring with a glass rod to fully dissolve, and obtaining a first mixed solution;

[0015] S3. Adding the polysaccharide of Ganoderma lucidum to the first mixed solution, ultrasonically dissolving it at 60°C to obtain a second mixed solution;

[0016] S4. The second mixed solution is drawn into the catheter mold through a 10 mL syringe and injected into the catheter mold. The catheter mold is fixed and placed flat in a large glass dish and placed in a refrigerator at -20°C overnight.

[0017] S5. Take out the catheter mold, remove the outer layer of the catheter mold, clamp the initial catheter wrapped with the inner core into the freeze-drying bottle with tweezers, cover the bottle stopper, put it horizontally in the refrigerator, and freeze it at -20℃ overnight;

[0018] S6. Freeze-dry the initial catheter; after the sample is completely freeze-dried, remove the freeze-drying bottle and take out the initial catheter wrapped with the inner core, carefully remove the inner core in the catheter wrapped with the inner core, and obtain the Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter; put the prepared Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter into a sealed bag; take out the Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter with Co before use. 60 Irradiate and sterilize for later use.

[0019] Furthermore, the catheter mold includes an outer tube, an inner core, an upper plug and a lower plug; the upper plug and the lower plug are both T-shaped and symmetrically arranged in the inner cavity at the upper and lower ends of the outer tube; a center hole is provided in the center of the middle cylindrical block of the upper plug and the lower plug; the inner core is sleeved in the outer tube and inserted in the center hole; wherein, the gap between the upper plug and the lower plug is a filling area for a medical catheter preparation solution, and an opening for injecting a medical catheter preparation solution is also provided at the tube body of the outer tube, and the medical catheter preparation solution is injected into the catheter preparation solution filling area along the opening.

[0020] The beneficial effects of the present application are as follows: the raw materials of the formula of the present application are widely available, low in price, and have the functions of adsorption, retention and grafting on the surface of medical polymer materials. The medical catheter prepared by the formula of the present application is non-toxic and immunologically inert, and improves the biocompatibility of medical polymer materials in contact with blood. The catheter prepared by the formula of the present application through the mold has a rich three-dimensional structure, which can provide a necessary pathway for the delivery of nutrients required for the growth process of nerve cells, and provide the necessary induction effect and necessary growth space for the growth of nerve cells. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is a scanning electron microscope image of a longitudinal section of an embodiment of the Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter of the present application;

[0022] Figure 2 This is a partial scanning electron microscope image of a longitudinal section of an embodiment of the Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter of the present application;

[0023] Figure 3 This is another partial scanning electron microscope image of the longitudinal section of an embodiment of the Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter of the present application;

[0024] Figure 4 It is a cross-sectional structural schematic diagram of an embodiment of the catheter mold of the present application;

[0025] Figure 5 It is a schematic diagram of the exploded structure of an embodiment of the catheter mold of the present application. DETAILED DESCRIPTION

[0026] In order to make the purpose, technical solutions and advantages of the present invention more clear, the present invention is further described in detail below in conjunction with specific embodiments.

[0027] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways than those described herein. Therefore, the present invention is not limited to the specific embodiments of the following disclosure.

[0028] The present application provides a ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter, which is a circular tube mesh support with a hollow middle, and a mixed solution of ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose is loaded on the support; each 100 ml of the medical catheter preparation solution contains the following components: 1-10 g of ganoderma lucidum polysaccharide, 1-10 g of bacterial cellulose, 2-30 ml of 10% tragacanth gum solution, and 10-100 ml of aqueous solution.

[0029] The mass percentage of tragacanth gum and pure water in the 10% tragacanth gum solution is 1:9.

[0030] Each 100 ml of the medical catheter preparation solution contains the following components: 3-7 g of ganoderma lucidum polysaccharide, 3-8 g of bacterial cellulose, 10-25 ml of 10% tragacanth gum solution, and 20-80 ml of aqueous solution.

[0031] Preferably, each 100 ml of the solution for preparing the medical catheter contains the following components: 5 g of Ganoderma lucidum polysaccharide, 68 g of bacterial cellulose, 20 ml of 10% tragacanth gum solution, and 50 ml of aqueous solution.

[0032] The present application also provides a method for preparing a Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter, comprising the following steps:

[0033] S1. The bacterial cellulose was soaked in 1% NaOH, heat treated at 60°C for 1h, and then washed with distilled water until neutral; the bacterial cellulose was then shredded and added to 10-100mL of aqueous solution, and the bacterial cellulose was sheared at high speed for 15min (speed 12kr / min) by a high shear emulsifier to obtain a bacterial cellulose slurry;

[0034] S2. slowly pouring the tragacanth gum solution into the bacterial cellulose slurry, stirring with a glass rod to fully dissolve, and obtaining a first mixed solution;

[0035] S3. Adding the polysaccharide of Ganoderma lucidum to the first mixed solution, ultrasonically dissolving it at 60°C to obtain a second mixed solution;

[0036] S4. The second mixed solution is drawn into the catheter mold through a 10 mL syringe and injected into the catheter mold. The catheter mold is fixed and placed flat in a large glass dish and placed in a refrigerator at -20°C overnight.

[0037] S5. Take out the catheter mold, remove the outer layer of the catheter mold, clamp the initial catheter wrapped with the inner core into the freeze-drying bottle with tweezers, cover the bottle stopper, put it horizontally in the refrigerator, and freeze it at -20℃ overnight;

[0038] S6. Freeze-dry the initial catheter; after the sample is completely freeze-dried, remove the freeze-drying bottle and take out the initial catheter wrapped with the inner core, carefully remove the inner core in the catheter wrapped with the inner core, and obtain the Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter; put the prepared Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter into a sealed bag; take out the Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter with Co before use. 60 Irradiate and sterilize for later use.

[0039] Among them, the catheter mold 10 includes an outer tube 11, an inner core 12, an upper plug 13 and a lower plug 14; the upper plug 13 and the lower plug 14 are both T-shaped and symmetrically arranged in the inner cavity 111 at the upper and lower ends of the outer tube 11; a center hole 142 is provided in the center of the middle cylindrical block 141 of the upper plug 13 and the lower plug 14; the inner core 2 is sleeved in the outer tube 1 and inserted in the center hole 142; wherein, the gap between the upper plug 13 and the lower plug 14 is a filling area for a medical catheter preparation solution, and an opening 112 for injecting a medical catheter preparation solution is also opened at the tube body of the outer tube 1, and the medical catheter preparation solution is injected into the catheter preparation solution filling area along the opening 112.

[0040] Example 1

[0041] Preparation of sample G1:

[0042] S1. Preparation of bacterial cellulose slurry: Weigh 6 g of flaky bacterial cellulose and soak it in 1% NaOH, heat treat it at 60°C for 1 hour, and then wash it with distilled water until it is neutral. Then, cut the bacterial cellulose into pieces and add it to 50 mL of aqueous solution. Use a high-shear emulsifier to high-speed shear the bacterial cellulose for 15 minutes (speed 12 kr / min) to obtain bacterial cellulose slurry.

[0043] S2. Weigh 20 mL of 10% tragacanth gum solution, slowly pour the tragacanth gum solution into the bacterial cellulose slurry, and stir to fully dissolve it to obtain a first mixed solution.

[0044] S3. Weigh 5 g of Ganoderma lucidum polysaccharide, add it to the first mixed solution, and stir it at 65°C for 3 hours to fully dissolve it to obtain a second mixed solution.

[0045] S4. The second mixed solution was drawn through a 10 mL syringe and injected into the Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter stent mold, and the catheter mold was fixed and placed flat in a large glass dish, and placed in a refrigerator at -20°C and frozen overnight;

[0046] S5. Use tweezers to clamp the catheter mold into the freeze-drying bottle, cover the bottle stopper, and place it horizontally in the -20℃ layer of the refrigerator. Freeze for 2 hours and then take out the catheter mold;

[0047] S6. Open the freeze dryer in advance, and when the temperature drops below -40°C and the vacuum drops to 0.02Pa, transfer the freeze-dried bottle to the freeze dryer and connect it to the vacuum pump. The freeze-drying time is 10 hours. After the sample is completely freeze-dried, remove the freeze-dried bottle and the catheter mold, and carefully remove the inner core in the catheter mold;

[0048] S7. Place the prepared catheter stent into a sealed bag, label it with the name and preparation time, and store it in a cool, dry place for a long time. Take out the catheter stent before use and use Co 60 Irradiate and sterilize for later use, and obtain sample G1.

[0049] Example 2

[0050] Preparation of sample G2:

[0051] S1. Preparation of bacterial cellulose slurry: Weigh 2 g of flaky bacterial cellulose and soak it in 1% NaOH, heat treat it at 60°C for 1 hour, and then wash it with distilled water until it is neutral. Then, cut the bacterial cellulose into pieces and add it to 70 mL of aqueous solution. Use a high-shear emulsifier to high-speed shear the bacterial cellulose for 15 minutes (speed 12 kr / min) to obtain bacterial cellulose slurry.

[0052] S2. Weigh 30 mL of 10% tragacanth gum solution, slowly pour the tragacanth gum solution into the bacterial cellulose slurry, and stir to fully dissolve it to obtain a first mixed solution.

[0053] S3. Weigh 1 g of Ganoderma lucidum polysaccharide, add it to the first mixed solution, and stir it ultrasonically at 65°C for 3 hours to fully dissolve it, thereby obtaining a second mixed solution.

[0054] S4. Draw the second mixed solution through a 10mL syringe and inject it into the Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter stent mold. Fix the catheter mold, place it flat in a large glass dish, and place it in a refrigerator at -20℃ to freeze overnight.

[0055] S5. Use tweezers to clamp the catheter mold into the freeze-drying bottle, cover the bottle stopper, and place it horizontally in the -20℃ layer of the refrigerator. Freeze for 2 hours and then take out the catheter mold.

[0056] S6. Open the freeze dryer in advance, and when the temperature drops below -40°C and the vacuum drops to 0.02Pa, transfer the freeze-dried bottle to the freeze dryer and connect it to the vacuum pump. The freeze-drying time is 10 hours. After the sample is completely freeze-dried, remove the freeze-dried bottle and the catheter mold, and carefully remove the inner core in the catheter mold.

[0057] S7. Place the prepared catheter stent into a sealed bag, label it with the name and preparation time, and store it in a cool, dry place for a long time. Take out the catheter stent before use and use Co 60 Irradiate and sterilize for later use, and obtain sample G2.

[0058] Example 3

[0059] Preparation of sample G3:

[0060] S1. Preparation of bacterial cellulose slurry: Weigh 4 g of flaky bacterial cellulose and soak it in 1% NaOH, heat treat it at 60°C for 1 hour, and then wash it with distilled water until it is neutral. Then, cut the bacterial cellulose into pieces and add it to 40 mL of aqueous solution. Use a high-shear emulsifier to high-speed shear the bacterial cellulose for 15 minutes (speed 12 kr / min) to obtain bacterial cellulose slurry.

[0061] S2. Weigh 5 mL of 10% tragacanth gum solution, slowly pour the tragacanth gum solution into the bacterial cellulose slurry, and stir to fully dissolve it to obtain a first mixed solution.

[0062] S3. Weigh 3 g of Ganoderma lucidum polysaccharide, add it to the first mixed solution, and stir it ultrasonically at 65°C for 3 hours to fully dissolve it, thereby obtaining a second mixed solution.

[0063] S4. Draw the second mixed solution through a 10mL syringe and inject it into the Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter stent mold. Fix the catheter mold, place it flat in a large glass dish, and place it in a refrigerator at -20℃ to freeze overnight.

[0064] S5. Use tweezers to clamp the catheter mold into the freeze-drying bottle, cover the bottle stopper, and place it horizontally in the -20℃ layer of the refrigerator. Freeze for 2 hours and then take out the catheter mold.

[0065] S6. Open the freeze dryer in advance, and when the temperature drops below -40°C and the vacuum drops to 0.02Pa, transfer the freeze-dried bottle to the freeze dryer and connect it to the vacuum pump. The freeze-drying time is 10 hours. After the sample is completely freeze-dried, remove the freeze-dried bottle and the catheter mold, and carefully remove the inner core in the catheter mold.

[0066] S7. Place the prepared catheter stent into a sealed bag, mark the name and preparation time, and store it in a cool, dry place for a long time. Before use, take out the catheter stent and disinfect it with Co60 irradiation for later use, and obtain sample G3.

[0067] The porosity and tensile load of the partitioned spinal cord scaffolds prepared by the three groups of formulas G1, G2 and G3 were tested respectively. The test results are shown in Table 1

[0068] Table 1 Comparison of sample testing

[0069] Group Porosity Maximum load G1 >60％ 6.182N G2 Poor molding 0.877N G3 <45％ 3.0351N

[0070] As shown in Table 1, the G1 group formula has good porosity and mechanical strength, which can better meet the requirements of the field of cell culture and cell product research, and is a good medical catheter scaffold for tissue engineering research.

[0071] The beneficial effects of this application are:

[0072] (1) The raw materials of the formula of the present application are widely available and inexpensive, and have the functions of adsorption, retention and grafting on the surface of medical polymer materials.

[0073] (2) The medical catheter prepared by the formulation of the present application is non-toxic and immunologically inert, and improves the biocompatibility of medical polymer materials in contact with blood.

[0074] (3) The conduit prepared by the mold using the formula of the present application has a rich three-dimensional structure, which can provide a necessary pathway for the delivery of nutrients required for the growth of nerve cells, and provide the necessary induction and growth space for the growth of nerve cells.

[0075] (4) The spinal cord scaffold obtained by the preparation method of the present application has excellent mechanical strength, with a maximum load of 6.182N.

[0076] The above description is only an embodiment of the present application and does not limit the patent scope of the present application. Any equivalent structure or equivalent process transformation made using the contents of the present application specification and drawings, or directly or indirectly used in other related technical fields, are also included in the patent protection scope of the present application.

Claims

1. A Ganoderma lucidum polysaccharide-astragalus gum-bacterial cellulose medical catheter, characterized in that: Each 100 ml of the medical catheter preparation solution contains the following components: 1-10 g of ganoderma lucidum polysaccharide, 1-10 g of bacterial cellulose, 2-30 ml of 10% tragacanth gum solution, and 10-100 ml of aqueous solution.

2. The Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter according to claim 1, characterized in that: Each 100 ml of the solution for preparing the medical catheter contains the following components: 3-7 g of ganoderma lucidum polysaccharide, 3-8 g of bacterial cellulose, 10-25 ml of 10% tragacanth gum solution, and 20-80 ml of aqueous solution.

3. The Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter according to claim 1, characterized in that: Each 100 ml of the solution for preparing the medical catheter contains the following components: 5 g of ganoderma lucidum polysaccharide, 68 g of bacterial cellulose, 20 ml of 10% tragacanth gum solution, and 50 ml of aqueous solution.

4. The Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter according to claim 1, characterized in that: The mass percentage of tragacanth gum and pure water in the 10% tragacanth gum solution is 1:

9.

5. The Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter according to claim 1, characterized in that the medical catheter is a circular tube mesh support with a hollow middle, and the support is loaded with a mixed solution of Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose.

6. A method for preparing a Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter, characterized in that: The following steps are involved: S1. The bacterial cellulose was soaked in 1% NaOH, heat treated at 60°C for 1h, and then washed with distilled water until neutral; the bacterial cellulose was then shredded and added to 10-100mL of aqueous solution, and the bacterial cellulose was sheared at high speed for 15min (speed 12kr / min) by a high shear emulsifier to obtain a bacterial cellulose slurry; S2. slowly pouring the tragacanth gum solution into the bacterial cellulose slurry, stirring with a glass rod to fully dissolve, and obtaining a first mixed solution; S3. Adding the polysaccharide of Ganoderma lucidum to the first mixed solution, ultrasonically dissolving it at 60°C to obtain a second mixed solution; S4. The second mixed solution is drawn into the catheter mold through a 10 mL syringe, and the catheter mold is fixed, placed flat in a large glass dish, and placed in a refrigerator at -20°C overnight; S5. Take out the catheter mold, remove the outer layer of the catheter mold, clamp the initial catheter wrapped with the inner core into the freeze-drying bottle with tweezers, cover the bottle stopper, put it horizontally in the refrigerator, and freeze it at -20°C overnight; S6. freeze-dry the initial catheter; after the sample is completely freeze-dried, remove the freeze-drying bottle and take out the initial catheter wrapped with the inner core, carefully remove the inner core in the catheter wrapped with the inner core, and obtain the Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter; put the prepared Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter into a sealed bag; take out the Ganoderma lucidum polysaccharide-tragacanth gum-bacterial cellulose medical catheter with Co before use. 60 Irradiate and sterilize for later use.

7. The method according to claim 6, characterized in that The catheter mold includes an outer tube, an inner core, an upper plug and a lower plug; the upper plug and the lower plug are both T-shaped and symmetrically arranged in the inner cavity at the upper and lower ends of the outer tube; a center hole is provided in the center of the middle cylindrical block of the upper plug and the lower plug; the inner core is sleeved in the outer tube and inserted in the center hole; wherein the gap between the upper plug and the lower plug is a filling area for a medical catheter preparation solution, and an opening for injecting a medical catheter preparation solution is also provided at the tube body of the outer tube, and the medical catheter preparation solution is injected into the catheter preparation solution filling area along the opening.

Images