A selenium-containing hyperbranched polymer, its preparation method and application

By preparing selenium-containing hyperbranched polymers, the problem of difficult to achieve artificial proton channel selectivity and transmission rate is solved, efficient and selective proton transmission is achieved, and significant anti-cancer activity is demonstrated.

CN119735820BActive Publication Date: 2025-06-24HANGZHOU NORMAL UNIVERSITY
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Patent Information

Application Number
CN202411927323.5
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-12-25
Publication Date
2025-06-24
Estimated Expiration
2044-12-25

AI Technical Summary

Technical Problem

There are challenges in developing artificial proton channel systems that meet the high transmission efficiency, significant ion selectivity and gating properties of natural channel proteins, especially in terms of selectivity and transmission rate of artificial proton channels.

Method used

Using a selenium-containing hyperbranched polymer, compound M1 is combined with a hyperbranched polymer by preparation method and reacted under nitrogen protection to obtain a selenium-containing hyperbranched polymer with redox regulation characteristics. This material can achieve in-situ redox switching under the action of GSH and H2O2 to control the transmission of protons.

Benefits of technology

It achieves highly selective and efficient proton transmission, has a transmission rate comparable to natural breccinin, and shows significant anti-cancer activity, can quickly change the intracellular pH value, induce apoptosis of cancer cells, and is significantly toxic to cancer cell lines such as melanoma B16F10 and malignant glioma U87MG.

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Abstract

The present invention discloses a selenium-containing hyperbranched polymer and its preparation method and application, belonging to the technical field of the preparation of intelligent bionic materials. The preparation method comprises the following steps: preparing compound M1; preparing the hyperbranched polymer; dissolving M1 in anhydrous dichloromethane, adding anhydrous DMF and oxalyl chloride, stirring, and removing the solvent and excessive oxalyl chloride under reduced pressure to obtain reactant A; under nitrogen protection, suspending the hyperbranched polymer and triethylamine in anhydrous tetrahydrofuran, stirring to obtain reactant B; dissolving reactant A in anhydrous tetrahydrofuran, dropping it into reactant B, heating to room temperature, stirring, removing the solvent, dissolving in anhydrous tetrahydrofuran, and dialyzing to obtain the selenium-containing hyperbranched polymer. The present invention provides a selenium-containing hyperbranched polymer and its preparation method and application. The selenium-containing hyperbranched polymer exhibits excellent anti-cancer activity, can rapidly change the intracellular pH value, and induce apoptosis of cancer cells.
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