Method for promoting transdermal absorption of aqueous composition

Abstract

The invention provides a method for promoting percutaneous absorption of a water-based composition, which comprises the following steps: the water-based composition is sprayed to the surface of a human body, the kinematic viscosity V of the water-based composition is 0.95-2.40 mm < 2 > / s, and when the water-based composition is sprayed to the surface of the human body, the spraying impact force at the position 10 cm away from a spraying opening is 2.5 * 10 <-3 >-2.4 * 10 <-2 > Newton; at the position 20-30 cm away from a spraying opening, the average particle size of fog drops formed by spraying is 8.5-80 microns, and the method can still achieve a good skin permeation effect under the condition that the surface tension of the water-based composition is not reduced. Therefore, the method provided by the invention can realize a good skin permeation effect without depending on reduction of the surface tension of the product.

Description

Technical Field

[0001] The present application relates to the technical field of skin care, and in particular to a method for promoting transdermal absorption of an aqueous composition. Background Art

[0002] Water-based cosmetics such as lotions and emulsions, which are mainly composed of water, have a refreshing feeling that oily cosmetics do not have. They have become increasingly popular among consumers in recent years. However, since the skin is basically lipophilic, they are relatively poor in affinity and penetration. How to make water-based cosmetics better penetrate the skin barrier and penetrate into the living cell layer inside the skin is the key to the effectiveness of water-based cosmetics.

[0003] To this end, the existing technology usually reduces the surface tension of water-based cosmetics, for example, reducing the surface tension to below 33mN / m, so that the liquid penetrates into the lipid gaps of the stratum corneum and disrupts its arrangement to achieve penetration. This penetration method will cause irreversible damage to the skin barrier in a short period of time, resulting in the loss of natural moisturizing factors of the skin, the entry of external irritants into the skin, and inducing reactions such as inflammation.

[0004] How to promote the transdermal absorption of water-based cosmetics while avoiding the above-mentioned damage to the skin is the technical problem that this application aims to solve. Summary of the invention

[0005] To this end, after in-depth research, the inventors of the present application found that even without reducing the surface tension of the aqueous composition, by controlling the kinematic viscosity of the aqueous composition and the spraying conditions, the aqueous composition can achieve good penetration, thereby avoiding damage to the skin by low surface tension liquids.

[0006] The specific technical solutions of this application are as follows:

[0007] 1. A method for promoting transdermal absorption of an aqueous composition, comprising:

[0008] Spraying the aqueous composition onto the human body surface,

[0009] Wherein, the kinematic viscosity V of the aqueous composition is 0.95-2.40 mm 2 / s,

[0010] When the aqueous composition is sprayed onto the human body surface, the spraying impact force at a distance of 10 cm from the spraying port is 2.5*10 -3 ~2.4*10 -2 Newton;

[0011] At a distance of 20 to 30 cm from the spraying port, the average particle size of the droplets formed by the spraying is 8.5 to 80 microns.

[0012] 2. The method according to item 1, wherein the surface tension S of the aqueous composition is 22 to 65 mN / m, preferably 33 mN / m <S≤65mN / m。

[0013] 3. The method according to claim 1, wherein the kinematic viscosity V of the aqueous composition is 0.98 to 2.21 mm 2 / s.

[0014] 4. The method according to claim 1, wherein the spraying impact force is 3.0*10 -3 ~2.4*10 -2 Newton.

[0015] 5. The method according to any one of items 1 to 4, wherein the average particle size of the droplets formed by spraying is 8.7 to 77.4 microns.

[0016] 6. An aqueous composition for use in the method according to any one of items 1 to 5, wherein the kinematic viscosity V of the aqueous composition is 0.95 to 2.40 mm 2 / s.

[0017] 7. The aqueous composition according to item 6, wherein the surface tension S of the aqueous composition is 22 to 65 mN / m, preferably 33 mN / m <S≤65mN / m。

[0018] 8. The aqueous composition according to item 6 or 7, wherein the kinematic viscosity V of the aqueous composition is 0.98 to 2.21 mm 2 / s.

[0019] 9. Use of the aqueous composition described in any one of items 6 to 8 in the preparation of a spray product.

[0020] Effects of the Invention

[0021] The method provided in the present application can achieve good skin penetration without reducing the surface tension of the aqueous composition. This shows that the method provided in the present application can achieve good skin penetration without relying on reducing the surface tension of the product.

[0022] Furthermore, since the spraying method provided in the present application can be applied to aqueous compositions with high and low surface tensions, the selection range of products to be sprayed is wider. In particular, when it is desired to avoid damage to the skin caused by low surface tension liquids, the present application provides an effective solution. DETAILED DESCRIPTION

[0023] The present application is described in detail below in conjunction with the described embodiments. Although specific embodiments of the present application are shown, it should be understood that the present application can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided to enable a more thorough understanding of the present application and to enable the scope of the present application to be fully communicated to those skilled in the art.

[0024] It should be noted that certain words are used in the specification and claims to refer to specific components. Those skilled in the art should understand that technicians may use different nouns to refer to the same component. This specification and claims do not use the difference in nouns as a way to distinguish components, but use the functional differences of components as the criterion for distinction. As mentioned throughout the specification and claims, "including" or "comprising" are open-ended terms and should be interpreted as "including but not limited to". The subsequent description of the specification is a preferred embodiment of the present application, but the description is based on the general principles of the specification and is not intended to limit the scope of the present application. The scope of protection of the present application shall be determined by the attached claims.

[0025] The present application provides a method for promoting transdermal absorption of an aqueous composition, comprising:

[0026] Spraying the aqueous composition onto the human body surface,

[0027] Wherein, the kinematic viscosity V of the aqueous composition is 0.95-2.40 mm 2 / s,

[0028] When the aqueous composition is sprayed onto the human body surface, the spraying impact force at a distance of 10 cm from the spraying port is 2.5*10 -3 ~2.4*10 -2 Newton;

[0029] At a distance of 20 to 30 cm from the spraying port, the average particle size of the droplets formed by the spraying is 8.5 to 80 microns.

[0030] For example, the kinematic viscosity V of the aqueous composition may be 0.95 to 2.40 mm 2 / s, specifically 0.95mm 2 / s, 0.96mm 2 / s, 0.97mm 2 / s, 0.98mm 2 / s, 0.99mm 2 / s, 1.00mm 2 / s, 1.01mm 2 / s, 1.02mm 2 / s, 1.03mm 2 / s, 1.04mm2 / s, 1.05mm 2 / s, 1.06mm 2 / s, 1.07mm 2 / s、1.08mm 2 / s, 1.09mm 2 / s、1.10mm 2 / s, 1.11mm 2 / s, 1.12mm 2 / s, 1.13mm 2 / s、1.14mm 2 / s, 1.15mm 2 / s, 1.16mm 2 / s, 1.17mm 2 / s、1.18mm 2 / s, 1.19mm 2 / s, 1.20mm 2 / s, 1.30mm 2 / s, 1.40mm 2 / s, 1.50mm 2 / s, 1.60mm 2 / s, 1.70mm 2 / s, 1.80mm 2 / s, 1.90mm 2 / s, 2.00mm 2 / s, 2.10mm 2 / s, 2.20mm 2 / s, 2.30mm 2 / s, 2.35mm 2 / s, 2.40mm 2 / s, etc., preferably 0.98 to 2.21 mm 2 / s.

[0031] In the present application, there is no limitation on the method for measuring the kinematic viscosity V. A person skilled in the art may use conventional methods in the art to measure the kinematic viscosity V, for example, a capillary viscometer may be used for measurement.

[0032] In some embodiments, the kinematic viscosity V is measured at room temperature, and the room temperature refers to 20-25°C, such as 20°C, 21°C, 22°C, 23°C, 24°C, 25°C.

[0033] In some preferred embodiments, the kinematic viscosity V is measured at 25°C.

[0034] In some embodiments, when the aqueous composition is sprayed onto the human body surface, the spraying impact force at a distance of 10 cm from the spraying port is 2.5*10-3 ~2.4*10 -2 Newton, specifically 2.5*10 -3 Newton, 2.6*10 -3 Newton, 2.7*10 -3 Newton, 2.8*10 -3 Newton, 2.9*10 -3 Newton, 3.0*10 -3 Newton, 3.1*10 -3 Newton, 3.2*10 -3 Newton, 3.3*10 -3 Newton, 3.4*10 -3 Newton, 3.5*10 -3 Newton, 3.6*10 -3 Newton, 3.7*10 -3 Newton, 4.0*10 -3 Newton, 4.2*10 -3 Newton, 4.5*10 -3 Newton, 5.0*10 -3 Newton, 5.5*10 -3 Newton, 6.0*10 -3 Newton, 6.5*10 -3 Newton, 7.0*10 -3 Newton, 7.5*10 -3 Newton, 8.0*10 -3 Newton, 8.5*10 -3 Newton, 9.0*10 -3 Newton, 9.5*10 -3 Newton, 1.0*10 -2 Newton, 1.5*10 -2 Newton, 2.0*10 -2 Newton, 2.1*10 -2 Newton, 2.2*10 -2 Newton, 2.3*10 -2 Newton, 2.4*10 -2 Newton, etc., preferably 3.0*10 -3 ~2.2*10 -2 Newton.

[0035] In this application, there is no limitation on the method for measuring the impact force of spraying, and those skilled in the art can make a conventional selection based on actual needs. For example, a lightweight plastic plate can be placed on a balance, and the atomizing nozzle can be fixed 10 cm above the plastic plate, with the nozzle facing the center of the plate, and the maximum value M of the balance reading can be recorded, and the balance reading m after stopping atomization can be recorded. Then the impact force can be expressed as: F = (Mm) * g. Wherein, M and m are in SI units, and g is the acceleration of gravity.

[0036] In some embodiments, at a distance of 20 to 30 cm from the spray port, the average particle size of the droplets formed by the spraying can be 8.5 to 80 microns, specifically 8.5 microns, 9 microns, 10 microns, 15 microns, 20 microns, 25 microns, 30 microns, 35 microns, 40 microns, 45 microns, 50 microns, 55 microns, 60 microns, 65 microns, 70 microns, 75 microns, 80 microns, etc., preferably 8.7 to 77.4 microns.

[0037] In the present application, there is no limitation on the method for measuring the average particle size of droplets formed by spraying, and those skilled in the art can make a conventional selection based on actual needs, such as using a spray laser particle size analyzer for measurement.

[0038] The method provided by the present application can achieve good skin penetration without relying on reducing the surface tension of the product. Therefore, the selection range of the sprayed product is wider and can be applied to aqueous compositions with high and low surface tensions.

[0039] In some embodiments, the surface tension S of the aqueous composition is 22 to 65 mN / m, for example, 22 mN / m, 23 mN / m, 24 mN / m, 25 mN / m, 26 mN / m, 27 mN / m, 28 mN / m, 29 mN / m, 30 mN / m, 31 mN / m, 32 mN / m, 33 mN / m, 34 mN / m, 35 mN / m, 36 mN / m, 37 mN / m, 38 mN / m, 39 mN / m, 40 mN / m, 41 mN / m, 42mN / m, 43mN / m, 44mN / m, 45mN / m, 46mN / m, 47mN / m, 48mN / m, 49mN / m, 50mN / m, 51mN / m, 52mN / m, 53mN / m, 54mN / m, 55mN / m, 56mN / m, 57mN / m, 58mN / m, 59mN / m, 60mN / m, 61mN / m, 62mN / m, 63mN / m, 64mN / m, 65mN / m, etc., preferably 33mN / m <S≤65mN / m。

[0040] In the case where it is desired to avoid damage to the skin caused by a low surface tension liquid, the present application provides an effective solution. In some embodiments, the surface tension S of the aqueous composition is 33 mN / m < S ≤ 65 mN / m. The aqueous composition with a higher surface tension effectively avoids damage to the skin caused by a low surface tension liquid.

[0041] In the present application, there is no limitation on the method for measuring the surface tension S of the aqueous composition, and those skilled in the art can make a conventional selection based on actual needs. For example, the ring-pulling method commonly used in the art can be adopted for measurement.

[0042] In some embodiments, the surface tension S is measured at room temperature, and the room temperature refers to 20 - 25 °C, such as 20 °C, 21 °C, 22 °C, 23 °C, 24 °C, 25 °C.

[0043] In some preferred embodiments, the surface tension S is measured at 25 °C.

[0044] In the present application, the composition of the aqueous composition only needs to satisfy that the kinematic viscosity V at room temperature is 0.95 - 2.40 mm 2 / s, and it can further satisfy that the surface tension S is 22 - 65 mN / m. There is no limitation on the specific composition in the aqueous composition, and those skilled in the art can make a conventional selection based on actual needs.

[0045] For example, the aqueous composition contains at least a water-soluble active ingredient, a viscosity regulator, and water, and a surface tension regulator etc. can also be further added.

[0046] The viscosity regulator includes hydrophilic high molecular polymers, glycerol, propylene glycol, and / or trehalose etc. As the hydrophilic high molecular polymer, for example, hyaluronic acid or its salt, polyethylene glycol, polyvinyl alcohol, and / or gelatin etc.

[0047] The surface tension regulator includes surfactants, alcohols, and / or inorganic salts etc.

[0048] In the present application, the surfactant can be, for example, an anionic surfactant, a cationic surfactant, a non-ionic surfactant, and / or an amphoteric surfactant; for example, the surfactant can be sodium fatty acid, potassium fatty acid, sodium dodecylsulfonate, sodium dodecyl sulfate, sorbitol, lipopeptide, glucoside, 4-(1,1,3,3-tetramethylbutyl)phenyl-polyethylene glycol (Triton X-100), etc.;

[0049] The alcohols can include, for example, monohydric alcohols, dihydric alcohols, and polyhydric alcohols, such as ethanol, propylene glycol, butylene glycol, pentylene glycol, etc.;

[0050] The inorganic salt may be, for example, sodium chloride, magnesium chloride, potassium chloride, sodium sulfate, sodium sulfonate, or the like.

[0051] In the present application, there is no limitation on the content of the viscosity modifier for adjusting the kinematic viscosity in the aqueous composition. Those skilled in the art can adjust the content based on the kinematic viscosity requirements of the product. For example, the content of the viscosity modifier can be 0.01 to 20%.

[0052] In the present application, there is no limitation on the content of the surface tension regulator for adjusting the surface tension. Those skilled in the art can adjust the content based on the actual needs of the product for surface tension. For example, the content of the surface tension regulator can be 0.01 to 20%.

[0053] In some preferred embodiments, the human body surface is the human body surface after bathing. After bathing, the keratin in the stratum corneum of the skin will be overhydrated and increase in volume, thereby squeezing each other, making the stratum corneum that was originally tightly arranged like a brick wall structure become loose, and the skin barrier will be temporarily weakened, which is more conducive to skin penetration.

[0054] In some embodiments, the body surface comprises a hydrated body surface.

[0055] The methods described herein allow aqueous compositions to achieve good skin penetration.

[0056] The present application provides an aqueous composition for use in the above method, wherein the kinematic viscosity V of the aqueous composition at room temperature is 0.95 to 2.40 mm 2 / s.

[0057] For example, the kinematic viscosity V of the aqueous composition may be 0.95 mm 2 / s, 0.96mm 2 / s, 0.97mm 2 / s, 0.98mm 2 / s, 0.99mm 2 / s, 1.00mm 2 / s, 1.01mm 2 / s, 1.02mm 2 / s, 1.03mm 2 / s, 1.04mm 2 / s, 1.05mm 2 / s, 1.06mm 2 / s, 1.07mm 2 / s、1.08mm 2 / s, 1.09mm 2 / s、1.10mm 2 / s, 1.11mm2 / s, 1.12mm 2 / s, 1.13mm 2 / s、1.14mm 2 / s, 1.15mm 2 / s, 1.16mm 2 / s, 1.17mm 2 / s、1.18mm 2 / s, 1.19mm 2 / s, 1.20mm 2 / s, 1.30mm 2 / s, 1.40mm 2 / s, 1.50mm 2 / s, 1.60mm 2 / s, 1.70mm 2 / s, 1.80mm 2 / s, 1.90mm 2 / s, 2.00mm 2 / s, 2.10mm 2 / s, 2.20mm 2 / s, 2.30mm 2 / s, 2.35mm 2 / s, 2.40mm 2 / s, etc.

[0058] In some embodiments, the surface tension S of the aqueous composition is 22 to 65 mN / m, preferably 33 mN / m <S≤65mN / m。

[0059] For example, the surface tension S of the aqueous composition can be 22mN / m, 23mN / m, 24mN / m, 25mN / m, 26mN / m, 27mN / m, 28mN / m, 29mN / m, 30mN / m, 31mN / m, 32mN / m, 33mN / m, 34mN / m, 35mN / m, 36mN / m, 37mN / m, 38mN / m, 39mN / m, 40mN / m, 41mN / m, 42mN / m, m, 43mN / m, 44mN / m, 45mN / m, 46mN / m, 47mN / m, 48mN / m, 49mN / m, 50mN / m, 51mN / m, 52mN / m, 53mN / m, 54m N / m, 55mN / m, 56mN / m, 57mN / m, 58mN / m, 59mN / m, 60mN / m, 61mN / m, 62mN / m, 63mN / m, 64mN / m, 65mN / m, etc.

[0060] In some embodiments, the kinematic viscosity V of the aqueous composition at room temperature is 0.98 to 2.21 mm2 / s.

[0061] In the present application, the aqueous composition is a composition as defined above.

[0062] The present application provides the use of the above-mentioned aqueous composition in the preparation of a spray product.

[0063] The spray product may be, for example, a shower product, a beauty spray product, or the like.

[0064] Example

[0065] The present application provides a general and / or specific description of the materials and test methods used in the experiments. In the following examples, unless otherwise specified, % means wt%, i.e., weight percentage. The reagents or instruments used without indicating the manufacturer are all conventional reagent products that can be obtained commercially.

[0066] 1. Solution preparation

[0067] The tracer solution uses copper sulfate solution containing different concentrations of surfactants, and the effect of the method is judged by the transdermal penetration concentration of copper ions. Copper ions (copper sulfate) are used as tracers for skin penetration effects; on the one hand, because copper ions are colored, it is easy to observe the phenomenon intuitively in the experiment, and it is easy to quantify by the ICP method; on the other hand, metal ions have a large charge density and are usually very difficult to penetrate the skin barrier, which is mainly non-polar in nature. Its transdermal absorption can only be achieved under strong penetration-enhancing technology.

[0068] First, different solutions containing copper ions were prepared as shown in Table 1, and the surface tension and kinematic viscosity of the different solutions were measured. The results are shown in Table 1.

[0069] Among them, the surface tension is measured by the ring-pulling method, and the specific measurement method is as follows:

[0070] (1) Preparation of experimental instruments

[0071] Prepare a surface tension meter (including a pull-ring device), the liquid to be tested with known density, tweezers, a vernier caliper, distilled water, detergent, and absorbent cotton.

[0072] (2) Liquid preparation

[0073] Pour the liquid to be tested into a clean container. The depth of the liquid should ensure that the pull ring can be fully immersed and the liquid will not overflow when the pull ring is pulled up. At the same time, the temperature of the liquid should be kept stable because temperature affects surface tension. The container can be left for a while to allow the liquid temperature to reach equilibrium with the ambient temperature.

[0074] (3) Measurement operation

[0075] - Turn on the surface tension meter and carefully hang the cleaned pull ring on the hook of the instrument.

[0076] - Slowly lower the platform and immerse the pull ring into the liquid to be tested, taking care not to let the pull ring touch the wall of the vessel. The immersion depth should be appropriate, usually the pull ring is just completely immersed in the liquid.

[0077] - Wait for a while to allow the pull ring and liquid to fully contact and allow the surface tension of the liquid to act on the pull ring to reach a stable state.

[0078] -Then slowly and evenly raise the platform and read the maximum pulling force F when the pull ring leaves the liquid surface through the force measuring device of the instrument.

[0079] (4) Data recording and calculation

[0080] -Record the maximum pulling force F, the inner and outer diameters of the pull ring (assuming the inner diameter is D1 and the outer diameter is D2), and the temperature of the liquid.

[0081] -Calculated according to the formula for measuring surface tension (S) using the ring pull method.

[0082] - In order to reduce the error, repeat the above experimental steps at least 3-5 times, and calculate the average value of the surface tension obtained by multiple measurements as the final result.

[0083] The calculation formula of surface tension (S) is as follows:

[0084] S=F / π(D2+D1)

[0085] Here, π is the ratio of the circumference of a circle to its circumference.

[0086] The kinematic viscosity is measured using a capillary viscometer. The specific measurement method is as follows:

[0087] (1) Preparation of experimental instruments

[0088] Select a capillary viscometer with an appropriate range, a constant temperature water bath, a thermometer (with appropriate accuracy), a stopwatch, the raw materials to be tested, and an ear bulb.

[0089] (2) Absorbing samples

[0090] Use the ear suction bulb to suck an appropriate amount of the liquid to be tested, and slowly suck the liquid to be tested into the capillary viscometer, taking care not to produce bubbles. If there are bubbles, you need to suck them again, because bubbles will affect the flow of the liquid and the measurement results. When the liquid level of the liquid to be tested is slightly higher than the scale line on the viscometer, it is ready.

[0091] (3) Measurement operation

[0092] - Start timing: Let the liquid to be tested flow naturally in the capillary viscometer. When the lower edge of the liquid surface just reaches the upper scale line of the viscometer, immediately start the stopwatch to start timing.

[0093] -End timing: Observe the liquid surface carefully. When the lower edge of the liquid surface reaches the lower scale line of the viscometer, quickly press the stopwatch and record the time t (in seconds) taken for the liquid to flow between the two scale lines.

[0094] (4) Data recording and calculation

[0095] -Record data: record the time t, the temperature T of the constant temperature water bath, and the capillary constant C of the capillary viscometer.

[0096] - Calculate kinematic viscosity: Calculate the kinematic viscosity v (in mm) of the raw material at this temperature according to the kinematic viscosity calculation formula. 2 / s).

[0097] - In order to reduce the error, repeat the above experimental steps at least 3 times, and calculate the average value of the kinematic viscosity obtained by multiple measurements as the final result.

[0098] The formula for calculating kinematic viscosity is as follows:

[0099] v=C×t.

[0100] Table 1

[0101]

[0102] 2. Determination of spray parameters

[0103] The atomization effect of the essence can be adjusted by adjusting the two key parameters, namely the spraying impact force (F) and the average droplet particle size (P). The two key parameters are the spraying impact force (F) and the average droplet particle size (P).

[0104] The following method is used to measure the spraying impact force F:

[0105] Place a lightweight plastic plate on a 200-gram analytical balance and then peel it. Fix the atomizing nozzle 10 cm above the plastic plate, with the nozzle facing the center of the plate. Keep the spray on for 5 seconds, record the maximum value M of the balance reading, and record the balance reading m after stopping the atomization.

[0106] Spraying impact force F = (Mm) g.

[0107] Among them, M and m are SI units, and g is the acceleration due to gravity.

[0108] The measurement was repeated 6 times and the average value was taken. The results are shown in Table 2.

[0109] The droplet size distribution is measured in the following way:

[0110] The spray laser particle size analyzer was used to measure the particle size at a distance of 20 to 30 cm from the spray nozzle, and the average value was taken. The results are shown in Table 2.

[0111] 3. Determination of transdermal effect

[0112] During the test, a series of miniature pig skins were used. The pig skins were dehaired in advance, and the residual grease on the surface of the pig skins was cleaned with a 0.5% sodium dodecyl sulfate (SDS) solution. A circular area with a diameter of 5 cm was marked on the surface of the pig skin with an oily marker as the target position for atomization spraying. Thereafter, the pig skins were soaked in 40 degrees Celsius warm water for 15 minutes to simulate the state of excessive hydration of the stratum corneum. After immersion, the residual water film on the surface of the pig skin was not wiped off, and the surface was immediately sprayed with atomization of different tracer liquids (solutions in Table 1), the distance from the nozzle to the pig skin was controlled to be about 30 cm, the spraying time was 30 s, and the spraying flux was 3 ml / min liquid.

[0113] After the spray test, rinse the pigskin surface with clean water for 30 seconds, then wipe off the liquid on the pigskin surface with a paper towel, and let the pigskin stand at room temperature for 30 minutes. Then, cut the target position of the pigskin spray with scissors and take 0.5g for the next ICP test.

[0114] Soak the pig skin tissue in an appropriate amount of n-hexane for 24 hours to remove the fat, then remove the pig skin tissue and let the organic solvent evaporate naturally. Place the defatted pig skin tissue in a drying oven and dry it to constant weight at 40 degrees Celsius. Place the dried pig skin in a polytetrafluoroethylene digestion tank, add an appropriate amount of nitric acid and hydrogen peroxide, cover it with a lid and place it in a microwave digester for digestion. After the digestion is completed, take out the digestion tank and cool it to room temperature in a fume hood, then transfer the digestion solution to a volumetric flask, dilute to the mark with deionized water, shake well and set aside.

[0115] The sample solution after filtration and digestion was filtered using a 0.45 μm filter membrane, and then the copper ion content of the sample solution was measured using an inductively coupled plasma emission spectrometer. The results are shown in Table 2.

[0116] Table 2 Spray parameters and results

[0117]

[0118]

[0119] It can be seen from the above table that the aqueous compositions of Test Examples 11-25 and the Reference Example all have good penetration effects; in particular, Test Examples 11-25 can achieve penetration effects comparable to or even better than those of the Reference Example under higher surface tension.

[0120] The above is only the preferred embodiment of the present application, and does not limit the present application in other forms. Any technician familiar with the profession may use the above disclosed technical content to change or modify it into an equivalent embodiment with equivalent changes. However, any simple modification, equivalent change and modification made to the above embodiment based on the technical essence of the present application without departing from the technical solution of the present application still falls within the protection scope of the technical solution of the present application.

Claims

1. A method for promoting transdermal absorption of an aqueous composition, comprising: Spraying the aqueous composition onto the human body surface, Wherein, the kinematic viscosity V of the aqueous composition is 0.95-2.40 mm 2 / s, When the aqueous composition is sprayed onto the human body surface, the spraying impact force at a distance of 10 cm from the spraying port is 2.5*10 -3 ~2.4*10 -2 Newton; At a distance of 20 to 30 cm from the spraying port, the average particle size of the droplets formed by the spraying is 8.5 to 80 microns.

2. The method according to claim 1, wherein the surface tension S of the aqueous composition is 22 to 65 mN / m, preferably 33 mN / m <S≤65mN / m。 3. The method according to claim 1, wherein the kinematic viscosity V of the aqueous composition is 0.98 to 2.21 mm 2 / s.

4. The method according to claim 1, wherein the spraying impact force is 3.0*10 -3 ~2.2*10 -2 Newton.

5. The method according to any one of claims 1 to 4, wherein the average particle size of the droplets formed by spraying is 8.7 to 77.4 microns.

6. An aqueous composition for use in the method according to any one of claims 1 to 5, wherein The kinematic viscosity V of the aqueous composition is 0.95 to 2.40 mm 2 / s.

7. The aqueous composition according to claim 6, wherein the surface tension S of the aqueous composition is 22 to 65 mN / m, preferably 33 mN / m <S≤65mN / m。 8. The aqueous composition according to claim 6 or 7, wherein the kinematic viscosity V of the aqueous composition is 0.98 to 2.21 mm 2 / s.

9. Use of the aqueous composition according to any one of claims 6 to 8 in the preparation of a spray product.

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