A preparation method of isobutyramide thiazolyl resorcinol
Through amidation, halogenation and coupling reactions, combined with filtration and recrystallization, the problems of expensive, complex raw materials and serious pollution in the existing preparation of isobutylaminothiazolylresorcinol are solved, and an efficient and simple preparation method is achieved, with significantly improved product yield and purity.
Patent Information
- Application Number
- CN202411974985.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-31
- Publication Date
- 2025-09-30
- Estimated Expiration
- 2044-12-31
AI Technical Summary
The existing preparation methods of isobutyramide-thiazolyl resorcinol have the problems of expensive raw materials, complex reactions, serious pollution, low yield and low purity.
2-Aminothiazole and isobutyryl chloride undergo amidation reaction in the presence of an inorganic base to obtain intermediate 1; resorcinol and a halogenation reagent undergo halogenation reaction in the presence of a catalyst to obtain intermediate 2; then a coupling reaction is carried out in the presence of a zero-valent palladium catalyst and an organic solvent, and finally isobutyramidothiazolylresorcinol is obtained by filtration and recrystallization.
The invention realizes the preparation of isobutyramide-thiazolyl resorcinol with short route, low cost, environmental protection, simple post-treatment, high yield and high purity, low isomer impurity content and simple operation.