External traditional Chinese medicine formula for treating herpes zoster and preparation method of external traditional Chinese medicine formula

By combining the Mandala distillation liquid, atopic distillation liquid and asarum distillation liquid in the external formula of traditional Chinese medicine, the problem of insufficient scab and scab removal time in the treatment of shingles in the prior art is solved, and more effective pain and inflammation relief and tissue repair effects are achieved.

CN119818585APending Publication Date: 2025-04-15SHANDONG HUAWEI PHARM CO LTD
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Patent Information

Application Number
CN202510120529.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-01-25
Publication Date
2025-04-15

AI Technical Summary

Technical Problem

When the traditional Chinese medicine formula used in the prior art for the treatment of shingles in the treatment of shingles, the patient's scab time and scab removal time need to be further improved.

Method used

It provides a topical formula for traditional Chinese medicine, which contains components such as mandala distillation, atopic distillation, asarum distillation, etc. It can synergize the neuralgia and inflammatory reaction caused by shingles by paralyzing local nerve endings, stimulating the skin to produce a cool feeling, warm meridians and unclog meridians, anti-inflammatory and antibacterial effects.

Benefits of technology

This formula can significantly reduce the pain and inflammation caused by shingles, promote local blood circulation, accelerate tissue repair, and improve treatment effect.

✦ Generated by Eureka AI based on patent content.
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Abstract

The invention discloses an external traditional Chinese medicine formula for treating herpes zoster and a preparation method of the external traditional Chinese medicine formula, and relates to the technical field of traditional Chinese medicine formulas. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 15-30 parts of datura stramonium distillate, 15-25 parts of radix aconiti lateralis preparata distillate, 20-35 parts of asarum distillate, 5-15 parts of rheum officinale distillate, 5-15 parts of safflower distillate, 15-30 parts of radix angelicae distillate, 5-15 parts of borneol distillate, 10-20 parts of golden cypress distillate, 10-20 parts of carbonized sanguisorba root distillate and 10-20 parts of indigo naturalis distillate. According to the external traditional Chinese medicine formula for treating herpes zoster and the preparation method of the external traditional Chinese medicine formula, alkaloid components in the datura stramonium distillate can play a role in relieving pain by paralyzing local nerve endings, volatile oil components in the asarum distillate can stimulate local skin to generate a cool feeling and transfer attention to pain, and the volatile oil components also have a certain pain relieving effect; the radix aconiti lateralis praeparata slice distillate can warm and activate meridians, improve local blood circulation and relieve pain caused by qi and blood stasis.
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Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine formulas, in particular to a traditional Chinese medicine external-use formula for treating herpes zoster and a preparation method thereof. Background Art

[0002] The Chinese patent with the publication number CN105434689A discloses a Chinese medicine formula for treating herpes zoster, characterized in that each medicine is made of the following components in mass ratio: 10-13 grams of dried Polygonum multiflorum, 2-3 grams of nails, 13-17 grams of snake molting, 8-12 grams of sunflower seed shells, 4-6 grams of hair, 15-17 grams of honeycombs, 13-17 grams of seven-leaf lotus, and 10-12 milliliters of camellia oil; the processing method is: burn the above-mentioned nails, snake molting, sunflower seed shells and hair into charcoal ash; dry and grind the above-mentioned dried Polygonum multiflorum, honeycombs and seven-leaf lotus into powder; then put the above-mentioned charcoal ash and powder into a container, and then add the above-mentioned camellia oil and mix them evenly. The Chinese medicine for external use has a good effect on herpes zoster. 20 minutes after applying the medicine, the burning sensation of the affected skin is significantly reduced, and it can be cured in 2-3 courses of treatment, with an effective rate of 98%. However, when the traditional Chinese medicine formula prepared by the above-mentioned prior art solution is used, the scab formation time and scab removal time of the patient need to be further improved; to this end, the present invention provides a traditional Chinese medicine external-use formula for treating herpes zoster and a preparation method thereof to solve the above-mentioned problems. Summary of the invention

[0003] In view of the deficiencies in the prior art, the present invention provides a traditional Chinese medicine external-use formula for treating herpes zoster and a preparation method thereof, which solves the problems mentioned in the above background technology.

[0004] To achieve the above purpose, the present invention is implemented through the following technical scheme: a traditional Chinese medicine external-use formula for treating herpes zoster, which is prepared according to the following weight parts: 15-30 parts of Datura distillate, 15-25 parts of aconite distillate, 20-35 parts of asarum distillate, 5-15 parts of rhubarb distillate, 5-15 parts of safflower distillate, 15-30 parts of angelica distillate, 5-15 parts of borneol distillate, 10-20 parts of Phellodendron chinense distillate, 10-20 parts of Sanguisorba officinalis charcoal distillate, and 10-20 parts of Indigo naturalis distillate.

[0005] A method for preparing a traditional Chinese medicine external-use formula for treating herpes zoster, specifically comprising the following preparation steps: Step 1, distilling Datura stramonium, aconite root, asarum, rhubarb, safflower, angelica dahurica, borneol, phellodendron, charcoal of sanguisorba officinalis, and indigo respectively to obtain distillates; Step 2: Mix the distillates obtained above to obtain a Chinese medicine for external use for treating herpes zoster Preferably, the preparation method of the Datura distillate is: S1. Select fresh, pest-free and mature Datura plants, remove the roots, dead branches and leaves of the Datura plants, rinse the surface soil and dust with clean water, and then place them in a drying oven at 30-35°C to dry them to a moisture content of 10%-15%. Cut the pretreated Datura plants into small pieces with a length of 2-3 cm to increase the contact area between the raw material and the distillation medium and improve the distillation efficiency; S2, use a 50-500L steam distillation device and select a stainless steel distillation kettle; S3, mixing the small segments of Datura with water in a mass ratio of 1:5-1:8; S4. The temperature in the distillation kettle is raised to 90-100°C, and the temperature at the top of the distillation tower is raised to 40-50°C to ensure that the effective ingredients can be distilled out with the water vapor while reducing the carry-out of impurities. The distillation time is 3-5h, and the distillation is collected to obtain the Datura distillate.

[0006] Preferably, the entire preparation process of the Datura distillate is carried out under normal pressure; The preparation method of the datura distillate also includes filtering the collected datura distillate, which includes filtering with filter paper, centrifugal filtering or filtering with a 0.25-0.45 μm micromembrane.

[0007] Preferably, the preparation method of the aconite distillate is: (1) Select the processed aconite with solid texture, no mold, and be rinsed to remove dust and impurities on the surface, then use gauze to absorb the surface moisture, and use a Chinese medicine slicer to cut the aconite into slices with a thickness of 2-3 mm to increase the contact area between the raw material and the distillation medium, thereby improving the distillation efficiency; (2) Select a 100-1000L multifunctional Chinese medicine distillation equipment made of 304 stainless steel, connect it to a cooling device, and use a serpentine condenser or a shell-and-tube condenser; (3) Add distilled water in a mass ratio of 1:6-1:10 between the thin slices of aconite and the liquid. First, add the distilled water into the distillation pot, then add the thin slices of aconite, and stir evenly to fully soak the thin slices of aconite. (4) Heat the distillation pot to 100-110°C and distill for 4-6 hours. Collect the distilled liquid to obtain the aconite root.

[0008] Preferably, the entire preparation process of the aconite distillate is carried out by atmospheric distillation; The preparation method of the aconite distillate also includes filtering the collected aconite distillate, which includes filtering with filter paper, centrifugal filtering or filtering with a 0.25-0.45 μm micro-membrane.

[0009] Preferably, the preparation method of the asarum distillate is: ① Select dry, mildew-free and impurity-free asarum, remove the residual stems, mud and sand impurities in the asarum, then rinse with clean water and drain the water, cut the asarum into small pieces of 3-5cm to increase the contact area between the raw material and the distillation medium and improve the distillation efficiency; ② Use 30-300L stainless steel steam distillation equipment, which is equipped with a spiral condenser to enhance the condensation effect and reduce the loss of distillate; ③ Mix the small segments of Asarum with water in a mass ratio of 1:8-1:12, wherein water is first added to the distillation kettle, and then the Asarum medicinal materials are added, and stirred thoroughly; ④ Raise the temperature in the distillation kettle to 95-105°C, distill for 2-4 hours, and collect the asarum distillate.

[0010] Preferably, during the distillation process, the water is kept in a steady boiling state to promote the effective ingredients of Asarum to be distilled out with the water vapor.

[0011] Preferably, the entire preparation process of the asarum distillate is carried out by atmospheric distillation; The preparation method of the asarum distillate also includes filtering the collected asarum distillate, which includes filtering with filter paper, centrifugal filtering or filtering with a 0.25-0.45 μm micromembrane.

[0012] Preferably, the method further comprises adding a silver ion antibacterial liquid having a concentration of 25-75 ppm to the mixed distillate.

[0013] Beneficial Effects The present invention provides a Chinese medicine external-use formula for treating herpes zoster and a preparation method thereof. Compared with the prior art, the Chinese medicine external-use formula for treating herpes zoster and a preparation method thereof have the following beneficial effects: the alkaloid component in the datura distillate can exert an analgesic effect by paralyzing local nerve endings; the volatile oil component in the asarum distillate can stimulate the local skin to produce a cool feeling, divert attention from pain, and it also has a certain analgesic effect; the aconite distillate can warm the meridians and dredge the collaterals, improve local blood circulation, and relieve pain caused by qi and blood stasis; the combination of the three can relieve neuralgia caused by herpes zoster from multiple angles, and play a synergistic role in enhancing analgesia; and both the datura distillate and the asarum distillate have anti-inflammatory effects, which can reduce the inflammatory response caused by herpes zoster; the antibacterial properties of the asarum distillate can inhibit bacterial infection at the herpes site; the aconite distillate It also helps to reduce inflammatory reactions. When the three distillates are used together, the anti-inflammatory and antibacterial effects are superimposed on each other, which is beneficial to inhibit the development of inflammation after viral infection and reduce the risk of infectious complications. At the same time, the distillate of aconite root mainly warms the meridians and dredges the collaterals, which can promote blood circulation in the herpes zoster area and improve the local blood stasis. The distillates of Datura and Asarum can relieve pain and inflammation while also helping to maintain the normal metabolism of local tissues. The three can work together to better improve local blood circulation, accelerate tissue repair, and promote the recovery of herpes. In addition, safflower can promote blood circulation and dredge the meridians; Angelica dahurica has the effects of reducing swelling, draining pus, and relieving pain; Borneol has the effects of clearing heat and relieving pain, preserving and promoting tissue regeneration; Phellodendron chinense can clear heat and dry dampness, purge fire and detoxify; Sanguisorba officinalis charcoal has the effects of cooling blood and stopping bleeding, detoxifying and healing sores; Indigo naturalis can clear heat and detoxify, cool blood and eliminate spots. These drug combinations may have the comprehensive effects of clearing heat and detoxifying, promoting blood circulation and removing blood stasis, and relieving pain, helping to relieve the pain, erythema, blisters and other symptoms caused by herpes zoster and promote the regression of herpes. By adding antibacterial ingredients such as silver ion antibacterial liquid to the extracted distillate, the antiseptic and anti-mildew effect of the product is guaranteed. It also has a good therapeutic effect on skin wounds, boils, acne and acne.

[0014] When the traditional Chinese medicine external-use formula of the present invention is used, herpes zoster can relieve pain on the same day, and carbuncle will form on the second day without irritation and sequelae. For the sequelae of herpes zoster, a small dose can be injected or the skin can be rubbed to break the epidermis and then sprayed, so as to effectively treat the sequelae of herpes zoster, wound care, furuncle, diabetes complications and burns, etc., and prevent infection. DETAILED DESCRIPTION

[0015] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0016] Example 1 A method for preparing a traditional Chinese medicine external-use formula for treating herpes zoster, specifically comprising the following preparation steps: Step 1: Preparation of Datura distillate: S1. Select fresh, pest-free and mature Datura plants, remove the roots, dead branches and leaves of the Datura plants, rinse the surface soil and dust with clean water, and then place them in a drying oven at 30°C to dry them to a moisture content of 10%. Cut the pretreated Datura plants into small sections with a length of 2 cm to increase the contact area between the raw material and the distillation medium and improve the distillation efficiency; S2, using a 50L steam distillation device and a stainless steel distillation kettle; S3, mixing the small segments of Datura with water in a mass ratio of 1:5; S4. Under normal pressure, raise the temperature in the distillation kettle to 90°C and the temperature at the top of the distillation tower to 40°C to ensure that the effective ingredients can be distilled out with the water vapor while reducing the carryover of impurities. The distillation time is 3 hours and the distillation is collected to obtain the Datura distillate. S5, filtering the collected Datura distillate using filter paper; Step 2: Prepare the distilled solution of aconite root: (1) Select the processed aconite with solid texture, no mold, and be rinsed to remove the dust and impurities on the surface, then use gauze to absorb the surface moisture, and use a Chinese medicine slicer to cut the aconite into slices with a thickness of 2 mm to increase the contact area between the raw material and the distillation medium and improve the distillation efficiency; (2) Select a 100L multifunctional Chinese medicine distillation equipment made of 304 stainless steel, connect it to a cooling device, and use a serpentine condenser or a shell-and-tube condenser; (3) Add distilled water in a mass ratio of 1:6 between the aconite slices and the liquid. First, add the distilled water into the distillation pot, then add the aconite slices, and stir evenly to fully soak the aconite slices. (4) Under normal pressure, heat the distillation pot to 100°C, distill for 4 hours, and collect the distillate to obtain the aconite distillate; (5) centrifugation and filtration of the collected aconite distillate; Step 3: Preparation of Asarum distillate: ① Select dry, mildew-free and impurity-free asarum, remove the residual stems, mud and sand impurities in the asarum, then rinse with clean water and drain the water, cut the asarum into 3cm small sections to increase the contact area between the raw material and the distillation medium and improve the distillation efficiency; ② Use a 30L stainless steel steam distillation equipment equipped with a spiral condenser to enhance the condensation effect and reduce the loss of distillate; ③ Mix the small segments of Asarum with water in a mass ratio of 1:8, wherein water is first added to the distillation kettle, and then the Asarum medicinal materials are added, and stirred thoroughly; ④ Under normal pressure, the temperature in the distillation kettle is raised to 95°C, and the distillation time is 2 hours. During the distillation process, the water is kept in a steady boiling state to promote the effective ingredients of Asarum to be distilled out with the water vapor, and then collected to obtain Asarum distillate; ⑤ Filter the collected Asarum distillate using a 0.25 μm micro membrane; Step 4: Mix 15g of Datura distillate, 25g of Aconite root distillate, 35g of Asarum distillate, 5-15g of Rhubarb distillate, 5g of Carthamus tinctorius distillate, 15g of Angelica dahurica distillate, 5g of Borneolum distillate, 10g of Phellodendron amurense distillate, 10g of Sanguisorba officinalis distillate, and 10g of Indigo naturalis distillate, then add 25ppm of silver ion antibacterial solution to the mixed distillate, mix well, and obtain a traditional Chinese medicine external-use formula for treating herpes zoster.

[0017] Example 2 A method for preparing a traditional Chinese medicine external-use formula for treating herpes zoster, specifically comprising the following preparation steps: Step 1: Preparation of Datura distillate: S1. Select fresh, pest-free and mature Datura plants, remove the roots, dead branches and leaves of the Datura plants, rinse the surface soil and dust with clean water, and then place them in a drying oven at 32°C to dry them to a moisture content of 12%. Cut the pretreated Datura plants into small sections with a length of 2.5 cm to increase the contact area between the raw material and the distillation medium and improve the distillation efficiency; S2, using a 300L steam distillation device and a stainless steel distillation kettle; S3, mixing the small segments of Datura with water in a mass ratio of 1:6; S4. Under normal pressure, the temperature in the distillation kettle is raised to 95°C and the temperature at the top of the distillation tower is raised to 45°C to ensure that the effective ingredients can be distilled out with the water vapor while reducing the carryover of impurities. The distillation time is 4 hours and the distillation is collected to obtain the Datura distillate. S5, centrifugally filtering the collected Datura distillate; Step 2: Prepare the distilled solution of aconite root: (1) Select the processed aconite with solid texture and no mold, rinse it to remove dust and impurities on the surface, then dry the surface moisture with gauze, and use a Chinese medicine slicer to cut the aconite into slices with a thickness of 2.5 mm to increase the contact area between the raw material and the distillation medium and improve the distillation efficiency; (2) Select a 500L multifunctional Chinese medicine distillation equipment made of 304 stainless steel, connect it to a cooling device, and use a serpentine condenser or a shell-and-tube condenser; (3) Add distilled water in a mass ratio of 1:8 between the thin slices of aconite and the liquid. First, add the distilled water into the distillation pot, then add the thin slices of aconite, and stir evenly to fully soak the thin slices of aconite. (4) Under normal pressure, heat the distillation pot to 105°C for 5 hours and collect the distillate to obtain the aconite distillate; (5) Filter the collected aconite distillate using filter paper; Step 3: Preparation of Asarum distillate: ① Select dry, mildew-free and impurity-free asarum, remove the residual stems, mud and sand impurities in the asarum, then rinse with clean water and drain the water, cut the asarum into 4cm small sections to increase the contact area between the raw material and the distillation medium and improve the distillation efficiency; ② Use 200L stainless steel steam distillation equipment, which is equipped with a spiral condenser to enhance the condensation effect and reduce the loss of distillate; ③ Mix the small segments of Asarum with water in a mass ratio of 1:10, wherein water is first added to the distillation kettle, and then the Asarum medicinal materials are added, and stirred thoroughly; ④ Under normal pressure, the temperature in the distillation kettle is raised to 100°C, and the distillation time is 3 hours. During the distillation process, the water is kept in a steady boiling state to promote the effective components of Asarum to be distilled out with the water vapor, and then collected to obtain Asarum distillate; ⑤ Centrifugal filtration of the collected Asarum distillate; Step 4: Mix 20g of Datura distillate, 20g of Aconite root distillate, 30g of Asarum distillate, 10g of Rhubarb distillate, 10g of Carthamus tinctorius distillate, 20g of Angelica dahurica distillate, 10g of Borneolum distillate, 15g of Phellodendron chinense distillate, 15g of Sanguisorba officinalis distillate, and 15g of Indigo naturalis distillate, then add 50ppm of silver ion antibacterial solution to the mixed distillate, mix well, and obtain a traditional Chinese medicine external-use formula for treating herpes zoster.

[0018] Example 3 A method for preparing a traditional Chinese medicine external-use formula for treating herpes zoster, specifically comprising the following preparation steps: Step 1: Preparation of Datura distillate: S1. Select fresh, pest-free and mature Datura plants, remove the roots, dead branches and leaves of the Datura plants, rinse the surface soil and dust with clean water, and then place them in a drying oven at 35°C to dry them to a moisture content of 15%. Cut the pretreated Datura plants into small sections with a length of 3 cm to increase the contact area between the raw material and the distillation medium and improve the distillation efficiency; S2, using a 500L steam distillation device and a stainless steel distillation kettle; S3, mixing the small segments of Datura with water in a mass ratio of 1:8; S4. Under normal pressure, raise the temperature in the distillation kettle to 100°C and the temperature at the top of the distillation tower to 50°C to ensure that the effective ingredients can be distilled out with the water vapor while reducing the carryover of impurities. The distillation time is 5 hours and the distillation is collected to obtain the Datura distillate. S5, filtering the collected Datura distillate using a 0.45 μm micro membrane; Step 2: Prepare the distilled solution of aconite root: (1) Select the processed aconite with solid texture and no mold, rinse it to remove dust and impurities on the surface, then dry it with gauze, and cut it into slices with a thickness of 3 mm using a Chinese medicine slicer to increase the contact area between the raw material and the distillation medium and improve the distillation efficiency; (2) Select a 1000L multifunctional Chinese medicine distillation equipment made of 304 stainless steel, connect it to a cooling device, and use a serpentine condenser or a shell-and-tube condenser; (3) Add distilled water in a mass ratio of 1:10 between the fructus aconitifolii and the liquid. First, add the distilled water into the distillation pot, then add the fructus aconitifolii and stir evenly to fully soak the fructus aconitifolii. (4) Under normal pressure, heat the distillation pot to 110°C, distill for 6 hours, and collect the distillate to obtain the aconite distillate; (5) filtering the collected aconite distillate, including filtering with filter paper, centrifugal filtration or filtering with a 0.45 μm micromembrane; Step 3: Preparation of Asarum distillate: ① Select dry, mildew-free and impurity-free asarum, remove the residual stems and mud and sand impurities in the asarum, then rinse with clean water and drain the water, cut the asarum into 5 cm small sections to increase the contact area between the raw material and the distillation medium and improve the distillation efficiency; ② Use 300L stainless steel steam distillation equipment, which is equipped with a spiral condenser to enhance the condensation effect and reduce the loss of distillate; ③ Mix the small segments of Asarum with water in a mass ratio of 1:12, wherein water is first added to the distillation kettle, and then the Asarum medicinal materials are added, and stirred thoroughly; ④ Under normal pressure, the temperature in the distillation kettle is raised to 105°C for 4 hours. During the distillation process, the water is kept in a steady boiling state to promote the effective components of Asarum to be distilled out with the water vapor and collected to obtain Asarum distillate; ⑤ Filter the collected Asarum distillate using a 0.35 micron membrane; Step 4: Mix 30g of Datura distillate, 15g of Aconite root distillate, 20g of Asarum distillate, 15g of Rhubarb distillate, 15g of Carthamus tinctorius distillate, 30g of Angelica dahurica distillate, 15g of Borneolum distillate, 20g of Phellodendron chinense distillate, 20g of Sanguisorba officinalis distillate, and 20g of Indigo naturalis distillate, then add 75ppm of silver ion antibacterial solution to the mixed distillate, mix well, and obtain a traditional Chinese medicine external-use formula for treating herpes zoster.

[0019] Control group: conventional therapy: 0.5 g of ganciclovir for injection was mixed with 250 mL of 0.9% sodium chloride solution and intravenously dripped once a day.

[0020] The Chinese medicine formula prepared in Examples 1-3 was sprayed on the herpes zoster area once a day.

[0021] During this period, the patients' blister stopping time, scab formation time and scab removal time were observed; the results are shown in Table 1.

[0022] Table 1 Blister-stopping time Scabbing time Desculation time Example 1 2.36±1.21 7.32±1.47 11.23±2.09 Example 2 2.37±1.18 7.35±1.46 11.29±2.18 Example 3 2.37±1.12 7.34±1.58 11.25±1.96 Control group 3.35±1.33 9.38±2.26 16.15±3.42 Meanwhile, the contents not described in detail in this specification belong to the prior art known to those skilled in the art.

[0023] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0024] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine for external use for treating herpes zoster, characterized in that: The composition is prepared in the following parts by weight: 15-30 parts of Datura distillate, 15-25 parts of Aconite root distillate, 20-35 parts of Asarum distillate, 5-15 parts of Rhubarb distillate, 5-15 parts of Carthamus tinctorius distillate, 15-30 parts of Angelica dahurica distillate, 5-15 parts of Borneolum distillate, 10-20 parts of Phellodendron amurense distillate, 10-20 parts of Sanguisorba officinalis charcoal distillate, and 10-20 parts of Indigo naturalis distillate.

2. A method for preparing the Chinese medicine external-use formula for treating herpes zoster according to claim 1, characterized in that: The specific production steps include the following: Step 1, distilling Datura stramonium, aconite root, asarum, rhubarb, safflower, angelica dahurica, borneol, phellodendron, charcoal of sanguisorba officinalis, and indigo respectively to obtain distillates; Step 2: Mix the distillates obtained above to obtain a traditional Chinese medicine external-use formula for treating herpes zoster.

3. A method for preparing a Chinese medicine for external use for treating herpes zoster according to claim 2, characterized in that: The preparation method of the datura distillate is: S1. Select fresh, pest-free and mature Datura plants, remove the roots, dead branches and leaves of the Datura plants, rinse the surface soil and dust with clean water, and then place them in a drying oven at 30-35°C to dry them to a moisture content of 10%-15%. Cut the pretreated Datura plants into small pieces with a length of 2-3 cm to increase the contact area between the raw material and the distillation medium and improve the distillation efficiency; S2, use a 50-500L steam distillation device and select a stainless steel distillation kettle; S3, mixing the small segments of Datura with water in a mass ratio of 1:5-1:8; S4. The temperature in the distillation kettle is raised to 90-100°C, and the temperature at the top of the distillation tower is raised to 40-50°C to ensure that the effective ingredients can be distilled out with the water vapor while reducing the carry-out of impurities. The distillation time is 3-5h, and the distillation is collected to obtain the Datura distillate.

4. A method for preparing a Chinese medicine for external use for treating herpes zoster according to claim 3, characterized in that: The entire preparation process of Datura distillate is carried out under normal pressure; The preparation method of the datura distillate also includes filtering the collected datura distillate, which includes filtering with filter paper, centrifugal filtering or filtering with a 0.25-0.45 μm micromembrane.

5. The method for preparing a Chinese medicine for external use for treating herpes zoster according to claim 2, characterized in that: The preparation method of the aconite distillate is: (1) Select the processed aconite with solid texture, no mold, and be rinsed to remove dust and impurities on the surface, then use gauze to absorb the surface moisture, and use a Chinese medicine slicer to cut the aconite into slices with a thickness of 2-3 mm to increase the contact area between the raw material and the distillation medium, thereby improving the distillation efficiency; (2) Select a 100-1000L multifunctional Chinese medicine distillation equipment made of 304 stainless steel, connect it to a cooling device, and use a serpentine condenser or a shell-and-tube condenser; (3) Add distilled water in a mass ratio of 1:6-1:10 between the thin slices of aconite and the liquid. First, add the distilled water into the distillation pot, then add the thin slices of aconite, and stir evenly to fully soak the thin slices of aconite. (4) Heat the distillation pot to 100-110°C and distill for 4-6 hours. Collect the distilled liquid to obtain the aconite root.

6. A method for preparing a Chinese medicine for external use for treating herpes zoster according to claim 5, characterized in that: The whole preparation process of the aconite distillate adopts the method of atmospheric distillation; The preparation method of the aconite distillate also includes filtering the collected aconite distillate, which includes filtering with filter paper, centrifugal filtering or filtering with a 0.25-0.45 μm micro-membrane.

7. A method for preparing a Chinese medicine for external use for treating herpes zoster according to claim 2, characterized in that: The preparation method of the asarum distillate is: ① Select dry, mildew-free and impurity-free asarum, remove the residual stems, mud and sand impurities in the asarum, then rinse with clean water and drain the water, cut the asarum into small pieces of 3-5cm to increase the contact area between the raw material and the distillation medium and improve the distillation efficiency; ② Use 30-300L stainless steel steam distillation equipment, which is equipped with a spiral condenser to enhance the condensation effect and reduce the loss of distillate; ③ Mix the small segments of Asarum with water in a mass ratio of 1:8-1:12, wherein water is first added to the distillation kettle, and then the Asarum medicinal materials are added, and stirred thoroughly; ④ Raise the temperature in the distillation kettle to 95-105°C, distill for 2-4 hours, and collect the asarum distillate.

8. A method for preparing a Chinese medicine for external use for treating herpes zoster according to claim 7, characterized in that: During the distillation process, the water is kept in a steady boiling state to promote the effective ingredients of Asarum to be distilled out with the water vapor.

9. The method for preparing a traditional Chinese medicine for external use for treating herpes zoster according to claim 7, characterized in that: The entire preparation process of asarum distillate adopts atmospheric distillation; The preparation method of the asarum distillate also includes filtering the collected asarum distillate, which includes filtering with filter paper, centrifugal filtering or filtering with a 0.25-0.45 μm micromembrane.

10. The method for preparing a traditional Chinese medicine for external use for treating herpes zoster according to claim 2, characterized in that: The method also includes adding silver ion antibacterial liquid with a concentration of 25-75ppm into the mixed distillate.

Citation Information

Patent Citations

  • External application traditional Chinese medicine formula treating herpes zoster

    CN105434689A