Stimulating electric field display method, device, system, equipment, medium and product

Abstract

The invention discloses a stimulating electric field display method, device, system and equipment, a medium and a product. The method comprises the steps that in response to a model display operation, a target object and a brain tissue image model corresponding to the target object are determined, and the brain tissue image model comprises at least one deep brain stimulation electrode model; in response to the electrode configuration operation, determining electrode configuration information and stimulation parameter application information of each electrode model; and in response to an electric field display operation, determining program-controlled electric field information of at least one electrode model under the electrode configuration information and the stimulation parameter application information, and displaying the program-controlled electric field information on the displayed brain tissue image model. Based on the technical scheme of the invention, the effect of quickly calculating and displaying the distribution condition of the program-controlled electric field simulated by any electrode configuration and the electrode model under the applied voltage on the brain tissue image model can be realized, and a technician can be effectively assisted in performing deep brain stimulation electrode configuration.

Description

Technical Field

[0001] The present invention relates to the field of electrical stimulation technology, and in particular to a stimulation electric field display method, device, system, equipment, medium and product. Background Art

[0002] Deep brain stimulation (DBS) is a technology that uses stereotactic surgery to implant electrodes in specific structures in the brain (i.e., target sites), and a neurostimulator implanted in the body sends electrical pulses to the target sites through the electrodes, thereby regulating the electrical activity and function of the corresponding neural structures and networks. The electrodes can include multiple poles, and different electrode configurations (polarity and applied voltage) can be set for each pole to achieve personalized neural stimulation for different subjects.

[0003] In the related art, electrode configuration usually relies on the experience of technicians. Due to the differences in experience of different technicians, it is usually difficult for the electric field under the electrode configuration to achieve the preset effect on the nerve stimulation of the target object. Therefore, there is currently a lack of a method that can assist technicians in DBS electrode configuration. Summary of the invention

[0004] The present invention provides a stimulation electric field display method, device, system, equipment, medium and product to solve the current lack of a method that can assist technicians in DBS electrode configuration.

[0005] According to one aspect of the present invention, a stimulation electric field display method is provided, the method comprising:

[0006] In response to the model display operation, determining a target object and a brain tissue image model corresponding to the target object, wherein the brain tissue image model includes at least one electrode model for deep brain stimulation;

[0007] In response to the electrode configuration operation, determining electrode configuration information and stimulation parameter application information of each of the electrode models, wherein the electrode model includes a plurality of target poles, and the electrode configuration information includes a target polarity of each of the target poles;

[0008] In response to the electric field display operation, the programmed electric field information of at least one of the electrode models under the electrode configuration information and the stimulation parameter application information is determined, and the programmed electric field information is displayed on the displayed brain tissue image model.

[0009] According to another aspect of the present invention, there is provided an analog program-controlled electric field display device, the device comprising:

[0010] A model display module, configured to determine a target object and a brain tissue image model corresponding to the target object in response to a model display operation, wherein the brain tissue image model includes at least one electrode model for deep brain stimulation;

[0011] An electrode configuration module, configured to determine electrode configuration information and stimulation parameter application information of each of the electrode models in response to an electrode configuration operation, wherein the electrode model includes a plurality of target poles, and the electrode configuration information includes a target polarity of each of the target poles;

[0012] The electric field display module is used to determine the programmed electric field information of at least one of the electrode models under the electrode configuration information and the stimulation parameter application information in response to the electric field display operation, and display the programmed electric field information on the displayed brain tissue image model.

[0013] According to another aspect of the present invention, an electronic device is provided, the electronic device comprising:

[0014] at least one processor; and

[0015] a memory communicatively connected to the at least one processor; wherein,

[0016] The memory stores a computer program executable by the at least one processor, and the computer program is executed by the at least one processor so that the at least one processor can execute the stimulation electric field display method described in any embodiment of the present invention.

[0017] According to another aspect of the present invention, a computer-readable storage medium is provided, wherein the computer-readable storage medium stores computer instructions, and the computer instructions are used to enable a processor to implement the stimulation electric field display method described in any embodiment of the present invention when executed.

[0018] The technical solution of the embodiment of the present invention determines the target object and the brain tissue image model corresponding to the target object in response to the model display operation, wherein the brain tissue image model includes at least one electrode model for deep brain stimulation; in response to the electrode configuration operation, determines the electrode configuration information and stimulation parameter application information of each electrode model, wherein the electrode model includes multiple target poles, and the electrode configuration information includes the target polarity of each target pole; in response to the electric field display operation, determines the program-controlled electric field information of at least one electrode model under the electrode configuration information and the stimulation parameter application information, and displays the program-controlled electric field information on the displayed brain tissue image model. The present invention achieves the effect of quickly calculating and displaying the distribution of the simulated program-controlled electric field of the electrode model under any electrode configuration and applied voltage on the brain tissue image model. The present invention can effectively assist technicians in DBS electrode configuration, and has strong versatility and can be applied to target objects of any brain structure.

[0019] It should be understood that the contents described in this section are not intended to identify the key or important features of the embodiments of the present invention, nor are they intended to limit the scope of the present invention. Other features of the present invention will become easily understood through the following description. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0021] Figure 1 is a flow chart of a stimulation electric field display method provided according to the first embodiment of the present invention;

[0022] Figure 2 is a scene example diagram of displaying programmable electric field information on the displayed brain tissue image model according to an embodiment of the present invention;

[0023] Figure 3 is a flow chart of a stimulation electric field display method provided according to the second embodiment of the present invention;

[0024] Figure 4 is a diagram showing an example of a scenario for determining program-controlled electric field information provided according to an embodiment of the present invention;

[0025] Figure 5 is a schematic structural diagram of an analog program-controlled electric field display device provided according to Embodiment 3 of the present invention;

[0026] Figure 6It is a schematic diagram of the structure of an electronic device for implementing the stimulation electric field display method of an embodiment of the present invention. DETAILED DESCRIPTION

[0027] In order to enable those skilled in the art to better understand the scheme of the present invention, the technical scheme in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0028] It should be noted that the terms "first", "second", etc. in the specification and claims of the present invention and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the data used in this way can be interchanged where appropriate, so that the embodiments of the present invention described herein can be implemented in an order other than those illustrated or described herein. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions, for example, a process, method, system, product or device that includes a series of steps or units is not necessarily limited to those steps or units that are clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.

[0029] First, one of the application fields of the embodiment of the present application (i.e., an implantable neural stimulation system) is briefly described.

[0030] Implantable medical systems include implantable neural stimulation systems, implantable cardiac stimulation systems (also known as pacemakers), implantable drug delivery systems (IDDS), and lead switching systems. Examples of implantable neural stimulation systems include deep brain stimulation (DBS), implantable cortical nerve stimulation (CNS), implantable spinal cord stimulation (SCS), implantable sacral nerve stimulation (SNS), and implantable vagus nerve stimulation (VNS).

[0031] The implantable neural electrical stimulation system includes a stimulator implanted in the patient's body (i.e., an implantable neural stimulator) and a programmable device disposed outside the patient's body. In other words, the stimulator is a medical device, or in other words, the medical device includes the stimulator. The relevant neural regulation technology mainly implants electrodes (electrodes, for example, in the form of electrode wires) in specific parts of the tissues of the organism (i.e., target points) through stereotactic surgery, and emits discharge pulses to the target points through the electrodes to regulate the electrical activity and function of the corresponding neural structures and networks, thereby improving symptoms and relieving pain.

[0032] As an example, DBS includes an IPG (Implantable Pulse Generator), an extension wire and an electrode wire, and the IPG is connected to the electrode wire via the extension wire. The IPG is implanted in the patient's body, for example, in the patient's chest or other body parts.

[0033] As another example, DBS includes an IPG and an electrode lead, and the IPG is directly connected to the electrode lead. The IPG is implanted in the patient's head, for example, a groove is made in the patient's skull, and then the IPG is installed in the groove of the skull. In this case, the IPG may not protrude from the outer surface of the skull, or may partially protrude from the outer surface of the skull.

[0034] Among them, IPG responds to the sample brain mask information sent by the program-controlled device, relying on sealed batteries and circuits to provide controllable electrical stimulation therapy (or electrical stimulation energy) to the tissues in the body. When the battery is low, the battery needs to be charged, and the method for charging the battery can be to use electromagnetic induction coil wireless charging to charge through human skin or other epidermal tissues. IPG delivers one or more controllable specific electrical stimulations to specific areas of tissues in the body through electrode wires.

[0035] In some embodiments, the extension lead is used in conjunction with the IPG as a transmission medium for electrical stimulation, and transmits the electrical stimulation generated by the IPG to the electrode lead.

[0036] In some embodiments, the electrical stimulation may be delivered in the form of a pulse signal or in the form of a non-pulse signal. For example, the electrical stimulation may be delivered as a signal having various waveform shapes, frequencies, and amplitudes. Thus, the electrical stimulation in the form of a non-pulse signal may be a continuous signal, which may have a sinusoidal waveform or other continuous waveform.

[0037] After receiving the electrical stimulation transmitted by the IPG or the extension wire, the electrode wire delivers the electrical stimulation to a specific area of ​​the tissue in the body through a plurality of electrode contacts. The stimulator is provided with, for example, one or more electrode wires on one side or both sides, and a plurality of electrode contacts are provided on the electrode wire, and the electrode contacts can be arranged uniformly or non-uniformly in the circumferential direction of the electrode wire. As an example, the electrode contacts can be arranged in an array of 4 rows and 3 columns (a total of 12 electrode contacts) in the circumferential direction of the electrode wire. The electrode contacts can include stimulation electrode contacts and / or collection electrode contacts. The electrode contacts can be in the shape of sheets, rings, dots, etc., for example.

[0038] In some embodiments, the stimulated in vivo tissue may be the patient's brain tissue, and the stimulated site may be a specific site of the brain tissue. When the patient's disease type is different, the stimulated site is generally different, and the number of stimulation contacts (single source or multiple sources), the use of one or more (single channel or multiple channels) of specific electrical stimulation, and the stimulation parameters (values) are also different.

[0039] The embodiments of the present application do not limit the types of diseases that can be used, and they can be the types of diseases that deep brain stimulation (DBS), spinal cord stimulation (SCS), sacral nerve stimulation, gastric stimulation, peripheral nerve stimulation, and functional electrical stimulation can be used for. Among them, the types of diseases that DBS can be used to treat or manage include, but are not limited to: spastic diseases (e.g., epilepsy), pain, migraine, mental illness (e.g., major depressive disorder (MDD)), bipolar disorder, anxiety, post-traumatic stress disorder, mild depression, obsessive-compulsive disorder (OCD), behavioral disorders, mood disorders, memory disorders, mental state disorders, movement disorders (e.g., essential tremor or Parkinson's disease), Huntington's disease, Alzheimer's disease, drug addiction, autism or other neurological or psychiatric diseases and injuries.

[0040] In the embodiment of the present application, when the programmable device and the stimulator establish a programmable connection, the programmable device can be used to adjust one or more stimulation parameters of the stimulator (or one or more stimulation parameters of the pulse generator, different stimulation parameters correspond to different electrical stimulations), and the stimulator can also sense the patient's electrophysiological activities to collect electrophysiological signals, and the collected electrophysiological signals can be used to continue to adjust the stimulation parameters of the stimulator, thereby realizing closed-loop control (or adaptive adjustment) of the stimulation parameters.

[0041] The stimulation parameters may include at least one of the following: the electrode contact identification used to deliver electrical stimulation (for example, electrode contact #2 and electrode contact #3), frequency (for example, the number of electrical stimulation pulse signals within a unit time of 1s, in Hz), pulse width (the duration of each pulse, in μs), amplitude (generally expressed in voltage, that is, the intensity of each pulse, in V), timing (for example, it can be continuous or burst, and burst refers to discontinuous timing behavior composed of multiple processes), stimulation mode (including one or more of current mode, voltage mode, timed stimulation mode and cyclic stimulation mode), upper and lower limits controlled by the doctor (the range that can be adjusted by the doctor) and upper and lower limits controlled by the patient (the range that can be adjusted autonomously by the patient).

[0042] In some embodiments, various stimulation parameters of the stimulator can be adjusted in current mode or voltage mode.

[0043] Programmable devices may include doctor programmable devices (i.e. programmable devices used by doctors) and / or patient programmable devices (i.e. programmable devices used by patients). Doctor programmable devices are, for example, tablet computers, laptop computers, desktop computers, mobile phones and other intelligent terminal devices equipped with programmable software. Patient programmable devices are, for example, tablet computers, laptop computers, desktop computers, mobile phones and other intelligent terminal devices equipped with programmable software. Patient programmable devices may also be other electronic devices with programmable functions (e.g., chargers with programmable functions, electrophysiological acquisition devices, etc.).

[0044] The embodiment of the present application does not restrict the data interaction between the doctor's programming device and the stimulator. When the doctor performs remote programming, the doctor's programming device can interact with the stimulator through the server and the patient's programming device. When the doctor performs offline programming with the patient face to face, the doctor's programming device can interact with the stimulator through the patient's programming device, and the doctor's programming device can also interact with the stimulator directly. The doctor sends a programming parameter group to the stimulator through the programming device. The programming parameter group (or the preset programming parameters mentioned below) includes multiple electrode contacts and stimulation parameters corresponding to each electrode contact.

[0045] In some embodiments, the patient programmable device may include a host (communicating with a server) and a slave (communicating with a stimulator), and the host and the slave are communicatively connected. Among them, the doctor programmable device can exchange data with the server through a 3G / 4G / 5G network, the server can exchange data with the host through a 3G / 4G / 5G network, the host can exchange data with the slave through a Bluetooth protocol / WIFI protocol / USB protocol, the slave can exchange data with the stimulator through a 401MHz-406MHz working frequency band / 2.4GHz-2.48GHz working frequency band, and the doctor programmable device can directly exchange data with the stimulator through a 401MHz-406MHz working frequency band / 2.4GHz-2.48GHz working frequency band.

[0046] Embodiment 1

[0047] Figure 1 A flowchart of a stimulation electric field display method is provided for the first embodiment of the present invention. This embodiment is applicable to the case where a program-controlled electric field display is performed before or during actual program control. The method can be performed by an analog program-controlled electric field display device, which can be implemented in the form of hardware and / or software. The analog program-controlled electric field display device can be configured in a computer or a doctor's program-controlled device. Figure 1 As shown, the method includes:

[0048] S110. In response to a model display operation, determine a target object and a brain tissue image model corresponding to the target object, wherein the brain tissue image model includes at least one electrode model for deep brain stimulation.

[0049] Among them, the model display operation can be understood as an operation of displaying the brain tissue image model of the target object. For example, after the patient completes the electrode implantation surgery, the doctor starts the programmed treatment. First, it is necessary to establish a three-dimensional image model of the patient's brain tissue based on the patient's postoperative images (such as CT images, X-ray images, etc.). On the doctor's side, the three-dimensional image model of the patient's brain tissue is displayed on the display screen of the programmed device (such as a computer, notebook, etc.).

[0050] Optionally, the model display operation may include an object selection operation and a model display operation, that is, an object selection operation control and a model display operation control are provided on the display screen, the object selection operation control is used to select a patient, so that the background can extract the treatment-related information of the patient (such as imaging parameters, electrode implantation parameters, patient identity information, etc.), and the model display operation control can selectively display relevant imaging models, such as implanted target nuclei, electrode trajectories of implanted electrodes, and a three-dimensional imaging model of the entire brain.

[0051] The object selection operation may be an operation of selecting the target object from at least one candidate object. Exemplarily, the object selection operation may be a click operation on the candidate object.

[0052] The model display operation may be an operation of displaying a brain tissue image model corresponding to the target object. Exemplarily, the model display operation may be a trigger operation for a model display control.

[0053] In the embodiment of the present invention, the object selection operation may be performed before the model display operation.

[0054] The target object may be an object to be subjected to actual deep brain stimulation, and the target object may be a patient, or a target area for electrode implantation, such as a target nucleus, etc. In an embodiment of the present invention, actual deep brain stimulation may be implemented based on deep brain stimulation (DBS) programming.

[0055] The brain tissue image model can be understood as an image model that can characterize the brain tissue structure of the target object.

[0056] In the embodiment of the present invention, the brain tissue image models of different target objects may be different. The brain tissue image model corresponding to each target object may be constructed based on a three-dimensional (3D) image of the target object.

[0057] The electrode model can be understood as a model corresponding to the target electrode. The target electrode can be an electrode actually implanted in the brain of the target object. For example, the target electrode can be a ring electrode. The display of the electrode model can show the actual positions of different electrode contacts in the brain tissue in the electrode model, which is convenient for the subsequent selection of the corresponding electrode contact to deliver the electrical pulse.

[0058] In another embodiment, the target electrode may be a segmented electrode, and the segmented electrode may be provided with a plurality of electrode sheets in the circumferential direction of the electrode wire, so that the direction of electric field stimulation can be adjusted when delivering electric pulses, thereby improving the accuracy and specificity of the stimulation.

[0059] In an embodiment of the present invention, the 3D image used to construct the brain tissue image model may include information of the target electrode.

[0060] It can be understood that by constructing a brain tissue imaging model, the actual position and status of the implanted electrode in the patient's brain can be intuitively displayed, which can help doctors to timely and accurately understand the position of each electrode contact in the target nucleus in the brain, so that appropriate electrode contacts can be selected for work, thereby improving the accuracy and efficiency of programmed treatment and reducing patient discomfort.

[0061] S120. In response to the electrode configuration operation, determine the electrode configuration information and stimulation parameter application information of each electrode model.

[0062] The electrode model includes a plurality of target poles, and the electrode configuration information includes a target polarity of each of the target poles.

[0063] The electrode configuration operation may be an operation of configuring electrode polarity. Optionally, the electrode configuration operation may be an operation of configuring the target polarity of each target pole in the electrode model for each electrode model.

[0064] Each of the target poles may correspond to an electrode sheet. The target polarity may include at least one of positive (+), negative (-) and empty (off).

[0065] In the embodiment of the present invention, the target pole included in the electrode model is related to the target electrode actually implanted in the brain of the target subject, and is not specifically limited here. Optionally, the electrode model may include a first pole, a second pole, and a third pole; the electrode model may include a first pole, a second pole, a third pole, and a fourth pole, etc.

[0066] The electrode configuration information may be understood as configuration information of the polarity of the target pole.

[0067] In the embodiment of the present invention, the electrode configuration information is related to the electrode configuration operation based on the user. The electrode configuration operation is related to the user demand and the scenario demand, which is not specifically limited here.

[0068] Optionally, in the case where the electrode model may include three target poles, namely, a first pole, a second pole and a third pole; the electrode configuration information may be that the target polarity of the first pole is a negative pole, the target polarity of the second pole is a negative pole, and the target polarity of the second pole is a positive pole;

[0069] Alternatively, the electrode configuration information may be that the target polarity of the first pole is a positive pole, the target polarity of the second pole is an empty pole, the target polarity of the second pole is a negative pole, and so on.

[0070] The stimulation parameter application information may characterize the parameters of the stimulation pulse applied to each of the target poles. The stimulation pulse may be represented by different stimulation dimensions, such as amplitude, frequency, pulse width, etc. In one embodiment of the present specification, the stimulation parameter application information may be the magnitude of the amplitude, that is, the magnitude of the stimulation output voltage. In an embodiment of the present invention, the applied voltage of the target pole that is the negative pole may be a value greater than 0. The applied voltage of the target pole that is the positive pole or the empty pole may be 0.

[0071] S130, determining the programmed electric field information of at least one of the electrode models under the electrode configuration information and the stimulation parameter application information, and displaying the programmed electric field information on the displayed brain tissue image model.

[0072] The electric field display operation can be understood as an operation of displaying the programmed electric field information. In the embodiment of the present invention, the programmed control can refer to DBS programming, which can refer to the process of applying voltage to the poles of the electrodes to generate an electric field, and has the actual effect of achieving deep brain stimulation.

[0073] The programmed electric field information can be understood as the distribution information of the programmed electric field on the brain tissue imaging model, such as the range of the stimulation electric field. In this way, according to the position of each electrode patch in the patient's brain, the range of brain tissue covered by the stimulation electric field range corresponding to each electrode patch can be intuitively seen through a three-dimensional display (such as the range of the nuclei that can be covered). Taking the circular electrode as an example, in general, the range of the stimulation electric field of the electrode patch should be a spherical stimulation field with the electrode patch as the center of the sphere, so that the size of the nuclei that can be covered by the spherical stimulation field can be observed, thereby assisting doctors in determining whether the spherical stimulation field can be used for effective stimulation therapy.

[0074] In an embodiment of the present invention, the programmed electric field information can be the electric field information of one electrode model, or it can be the superimposed electric field information of multiple electrode models, that is, stimulation pulses are delivered by multiple electrode sheets at the same time, so that a superimposed stimulation electric field can be formed to form a larger stimulation area.

[0075] like Figure 2 As shown, Figure 2 1 is a scene example diagram of displaying the program-controlled electric field information on the displayed brain tissue image model according to an embodiment of the present invention. 11 represents the electrode model, 22 represents the target pole, and 33 represents the program-controlled electric field information. Obviously, Figure 2 The electrode model shown includes four target poles, wherein, from top to bottom, the target polarities of the lower two target poles are negative.

[0076] The technical solution of the embodiment of the present invention determines the target object and the brain tissue image model corresponding to the target object in response to the model display operation, wherein the brain tissue image model includes at least one electrode model for deep brain stimulation; determines the electrode configuration information and stimulation parameter application information of each electrode model in response to the electrode configuration operation, wherein the electrode model includes multiple target poles, and the electrode configuration information includes the target polarity of each target pole; determines the program-controlled electric field information of at least one electrode model under the electrode configuration information and the stimulation parameter application information in response to the electric field display operation, and displays the program-controlled electric field information on the displayed brain tissue image model. The present invention realizes the effect of quickly calculating and displaying the distribution of the simulated program-controlled electric field of the electrode model under any electrode configuration and applied voltage on the brain tissue image model. The present invention can effectively assist technicians in DBS electrode configuration and fast and accurate program-controlled parameter selection, and has strong versatility and can be applied to target objects of any brain structure.

[0077] Figure 3 This is a flowchart of a stimulation electric field display method provided by an embodiment of the present invention. This embodiment refines the program-controlled electric field information for determining the electrode configuration information under the stimulation parameter application information described in the above embodiment. Figure 3 As shown, the method includes:

[0078] S210: In response to the model display operation, determine a target object and a brain tissue image model corresponding to the target object.

[0079] S220. In response to the electrode configuration operation, determine the electrode configuration information and stimulation parameter application information of each electrode model.

[0080] S230 , responding to the electric field display operation.

[0081] S240, determining the electric field information library of a single negative pole.

[0082] The electric field information library includes a plurality of alternative electric field information corresponding to the electrode model, and each of the alternative electric field information represents the distribution information of the simulated electric field generated by any target pole in the electrode model under a reference applied voltage on the brain tissue image model.

[0083] The electric field information library of the single negative pole may be understood as an information library for storing electric field information.

[0084] The alternative configuration information may be configuration information of a single negative pole. The single negative pole may refer to a pole having only one negative polarity in the electrode model. Optionally, one type of the alternative configuration information may represent an alternative electrode polarity configuration.

[0085] The reference applied voltage may be understood as a preset applied voltage used for reference calculation. In the embodiment of the present invention, optionally, the reference applied voltage may be 3V.

[0086] The alternative electric field information can be understood as the electric field information of the electrode model under the alternative configuration information and the reference applied voltage. The alternative electric field information can characterize the distribution of the simulated electric field generated by the electrode model under the alternative configuration information and the reference applied voltage on the brain tissue image model.

[0087] Optionally, before determining the electric field information library of the single negative pole, the method further includes:

[0088] Acquire a simulated tissue model of a patient's brain tissue, and implant at least one simulated electrode into the simulated tissue model to obtain a target simulated model;

[0089] Electric pulses are delivered to the simulation electrodes in the target simulation model according to a reference applied voltage to obtain candidate electric field information corresponding to each target pole.

[0090] Wherein, the simulated tissue model can be understood as a simulated model of the patient's brain tissue. Optionally, the simulated tissue model can include a physical model or a three-dimensional (3D) digital model. Similarly, the simulated electrode can be understood as a simulated model corresponding to the stimulation electrode. Optionally, the simulated electrode can include a physical model or a three-dimensional digital model.

[0091] In the embodiment of the present invention, the construction method of the simulated tissue model and the simulated electrode can be preset according to the scene requirements and is not specifically limited here. Exemplarily, the simulated tissue model of the patient's brain tissue or the simulated electrode of the stimulation electrode is constructed by digital twin technology or reverse engineering technology.

[0092] The target simulation model can be understood as a simulation tissue model in which simulation electrodes are implanted. In an embodiment of the present invention, the position of the simulation electrodes in the target simulation model is consistent with the position of the stimulation electrodes in the patient's brain tissue.

[0093] Specifically, electric pulses are delivered to the simulated electrodes in the target simulation model according to a reference applied voltage, and distribution information of the simulated electric field generated by each target pole under the reference applied voltage on the brain tissue imaging model is determined to obtain the alternative electric field information.

[0094] Based on the above embodiment scheme, by simulating the implantation of the simulation electrodes corresponding to the stimulation electrodes into the simulation tissue model corresponding to the patient's brain tissue, and further delivering electric pulses to the simulation electrodes, the effect of accurately obtaining the alternative electric field information corresponding to each target pole is achieved.

[0095] Optionally, before determining the electric field information library of the single negative pole, the method further includes:

[0096] For each target pole of the electrode model, the polarity of the target pole is set to a negative pole, and the polarities of other target poles except the negative electrode are set to a positive pole and / or a blank pole, and an electric pulse is delivered to the target electrode according to a reference applied voltage to obtain alternative electric field information corresponding to each target pole;

[0097] The electric field information library is constructed according to the candidate electric field information corresponding to each target pole in the electrode model.

[0098] Exemplarily, for each target pole of the electrode model, the polarity of the target pole is set to a negative pole, and the polarities of other target poles except the negative electrode are set to a positive pole and / or an empty pole as follows:

[0099] There are poles a, b, c and d on the electrode model A. For pole a, pole a is set as a negative pole; poles b, c and d are set as positive poles and / or empty poles, for example, pole b is a positive pole, pole c is a positive pole and pole d is a positive pole, or pole b is a positive pole, pole c is a positive pole and pole d is an empty pole, or pole b is a positive pole, pole c is an empty pole and pole d is an empty pole, until all possible positive and / or empty pole polarity settings are covered; further, the above operations are returned to perform in sequence for poles b, poles c and poles d to obtain an alternative electrode configuration for a single negative pole.

[0100] More specifically, for each alternative electrode configuration, an electric pulse is delivered to the target electrode under each alternative electrode configuration according to a reference applied voltage to obtain alternative electric field information corresponding to each target pole.

[0101] Based on the above embodiment, it is possible to achieve an effect that the alternative configuration information corresponding to the alternative electric field information in the electric field information library covers any electrode polarity configuration of the single negative pole corresponding to each electrode model.

[0102] Optionally, delivering electric pulses to the target electrodes according to the reference applied voltage to obtain alternative electric field information corresponding to each target pole includes:

[0103] Determining a correction coefficient associated with each target pole and the brain tissue image model, wherein the correction coefficient is at least associated with a location in the brain where the electrode is implanted into the target subject;

[0104] The candidate electric field information of each target pole is determined according to the reference applied voltage applied to each target pole and the correction coefficient.

[0105] Among them, the electrodes implanted in the brain of the target object can be used to perform electric field stimulation on the target object. The correction coefficient can be understood as the coefficient involved in the process of calculating the alternative electric field information. The correction coefficient can be one or more. The correction coefficient can be associated with at least the position of the brain where the electrode is implanted in the target object, and the correction coefficient can also be associated with the physical properties of the electrode itself. In an embodiment of the present invention, the correction coefficient can be set in advance according to the personalized characteristics of the brain tissue of the target patient, and no specific limitation is made here.

[0106] The correction coefficient can be different for different patients, that is, the biological tissue distribution of different patients' brains will be different. Combined with the different electrode implantation locations, the biological tissue environment of the electrodes will be different. In this way, when performing electrical stimulation, the diffusion characteristics of the electric field will also be different, resulting in different electric field atmospheres. When calculating the correction coefficient, it can be set according to the biological tissue environment where the electrodes are located, and of course the electrical characteristics of the electrodes themselves can also be considered. A targeted and personalized electric field model can be obtained, avoiding the use of a standard electric field and ignoring individual differences, and improving the accuracy and reliability of the electric field display.

[0107] Based on the above embodiment, it is possible to achieve the effect of constructing a single negative pole electric field information library that meets the personalized characteristics of the brain tissue of the target patient. Optionally, the correction coefficient includes at least one of the conductivity, dielectric constant and electrode material parameters of the brain tissue of the target subject.

[0108] The electrical conductivity can be understood as a measurement value that characterizes the ability of an electrode to transmit current.

[0109] The dielectric constant can be understood as a parameter of the dielectric property or polarization property of the piezoelectric material dielectric of the electrode under the action of an electrostatic field.

[0110] The electrode material parameters can be understood as parameters that characterize the characteristics of the physical material of the electrode. In an embodiment of the present invention, the electrode material parameters can be preset according to the scene requirements and are not specifically limited here. Exemplarily, the physical material of the electrode can be copper, silver, gold, graphene, etc., and correspondingly, the electrode material parameters can be parameters such as A, B, C, and D in sequence.

[0111] Based on the above embodiment scheme, correction coefficients such as conductivity, dielectric constant and electrode material parameters are introduced to determine the alternative electric field information, which can make the determined alternative electric field information closer to the actual situation and improve the reliability of subsequent program control parameter adjustment.

[0112] Optionally, determining the candidate electric field information of each target pole according to the reference applied voltage applied to each target pole and the correction coefficient includes:

[0113] Obtaining standard electric field information corresponding to each target pole according to the reference applied voltage applied to each target pole;

[0114] The standard electric field information is corrected according to the correction coefficient corresponding to each target pole to obtain the candidate electric field information corresponding to the target pole.

[0115] The standard electric field information may be understood as the distribution information of the electric field at the pole under the reference applied voltage.

[0116] Optionally, the correcting the standard electric field information according to the correction coefficient corresponding to each target pole may include:

[0117] According to the correction coefficient corresponding to each target pole, the standard electric field information is distributed and expanded to obtain the alternative electric field information corresponding to the target pole; or, according to the correction coefficient corresponding to each target pole, the standard electric field information is distributed and reduced to obtain the alternative electric field information corresponding to the target pole.

[0118] In actual application scenarios, the correction coefficient is set in advance based on the personalized characteristics of the patient's brain tissue.

[0119] Based on the above embodiment scheme, it is possible to construct an electric field information library of a single negative pole that meets the personalized characteristics of the brain tissue of the target patient. That is, the standard electric field information (standard electric field information of a single pole) is corrected in combination with the actual implantation environment of the electrode (brain tissue distribution and its own material), so as to obtain targeted alternative electric field information for different patients, avoid the use of a spherical standard electric field, improve the accuracy of the stimulation electric field display, and improve the reliability of subsequent program-controlled parameter adjustment.

[0120] S250. Determine at least one piece of electric field information to be combined from the electric field information library according to the electrode configuration information.

[0121] The electric field information to be combined can be understood as sub-electric field information that can be combined to obtain the programmed electric field information. In an embodiment of the present invention, when there is one electrode model and the electrode configuration information of the electrode model is a single negative pole, the electric field information to be combined can be one, otherwise, the electric field information to be combined can be multiple.

[0122] Optionally, determining at least one electric field information to be combined among a plurality of the candidate electric field information in the electric field information library according to the electrode configuration information comprises:

[0123] Determining an electric field information search rule corresponding to the target configuration category according to the target configuration category of the electrode configuration information;

[0124] According to the electric field information search rule, at least one electric field information to be combined corresponding to the electrode configuration information is searched in the plurality of candidate electric field information in the electric field information library.

[0125] The target configuration category can be understood as the category of the electrode configuration information. In an embodiment of the present invention, optionally, the target configuration category includes a single cathode category and / or a multiple cathode category, and the multiple cathode category includes an adjacent cathode category and / or a non-adjacent cathode category.

[0126] The electric field information search rule can be used to search for a rule of at least one of the electric field information to be combined that can be combined to obtain the program-controlled electric field information. In the embodiment of the present invention, the electric field information search rules corresponding to different target configuration categories can be different or the same.

[0127] Based on the above embodiment scheme, the effect of quickly acquiring the required electric field information to be combined can be achieved.

[0128] Specifically, taking the target configuration category of the electrode configuration information as the adjacent negative electrode category as an example, illustratively, the electrode model includes 4 poles, and the electrode configuration information is 1-, 2-, 3 empty, and 4 empty. Based on the electric field information search rule corresponding to the adjacent negative electrode category, it can be determined that the alternative configuration information corresponding to the electrode configuration information is 1-, 2+, and 1+, 2-. The alternative electric field information corresponding to the above two alternative configuration information is retrieved from the electric field information library, and the retrieved alternative electric field information is used as the electric field information to be combined.

[0129] Taking the target configuration category of the electrode configuration information as the single negative electrode category as an example, illustratively, the electrode configuration information is 1+, 2-, 3+, 4+, and the electric field information search rule can be to search from the negative electrode position to the left and right at the same time, find the nearest positive electrode respectively and then represent the remaining positive electrodes with space, so as to obtain the alternative configuration information corresponding to the electrode configuration information as 1+, 2-, 3+, retrieve the alternative electric field information corresponding to the above-mentioned alternative configuration information from the electric field information library, and use the retrieved alternative electric field information as the electric field information to be combined.

[0130] The technical solution of the embodiment of the present invention is based on the linear superposition principle of electric fields. By searching and combining pre-calculated and stored single-pole electric field distribution information, relevant electric field information (electric field information to be combined) can be quickly extracted from a pre-stored electric field information library to obtain programmable electric field information by combining the electric field.

[0131] S260. Determine a scaling parameter of each of the electric field information to be combined based on the stimulation parameter application information.

[0132] S270. Determine the program-controlled electric field information according to the at least one electric field information to be combined and its corresponding scaling parameter.

[0133] Optionally, determining the program-controlled electric field information according to at least one of the electric field information to be combined and the corresponding scaling parameter includes:

[0134] For each of the electrode models, determining actual electric field information of each of the target poles in the electrode model according to at least one of the electric field information to be combined and the scaling parameter corresponding to each of the electric field information to be combined;

[0135] Determining the positional relationship of a plurality of the target poles in the electrode model;

[0136] The plurality of actual electric field information are range-union processed according to the positional relationship to obtain the program-controlled electric field information corresponding to each electrode model.

[0137] Among them, the scaling parameter can be determined based on the ratio between the stimulation parameter application information and the reference applied voltage. Furthermore, the stimulation parameter application information delivered by different target poles can be different. In this way, in combination with the reference applied voltage, the scaling factors corresponding to different target poles may also be different. When calculating the program-controlled electric field information, the actual electric field information corresponding to each target pole can be obtained first according to the scaling factor and the alternative electric field information corresponding to each target pole, that is, the actual electric field range; then, combined with the positional relationship of different target poles in the implanted electrode, the actual electric field range corresponding to each target pole is range-union processed (that is, the intersecting parts are merged) to obtain the final program-controlled electric field information. Based on the above embodiment scheme, the reliability of the determined program-controlled electric field information is improved.

[0138] Figure 4 is an example diagram of a scenario for determining the program-controlled electric field information provided according to an embodiment of the present invention. Figure 4 As shown, it represents a scenario in which two electric field information to be combined are superimposed to obtain the programmable electric field information.

[0139] in, Figure 4 The alternative configuration information corresponding to the electric field information to be combined of the electrode model on the far left is that the polarity of the fourth (from top to bottom) target electrode is negative, and the alternative configuration information corresponding to the electric field information to be combined of the electrode model in the middle is that the polarity of the third (from top to bottom) target electrode is negative.

[0140] Specifically, the determining of the program-controlled electric field information according to the electric field information to be combined and the scaling parameter can be implemented based on the following formula:

[0141]

[0142] Wherein, E represents the electric field information to be combined, Ni represents multiple electric field information to be combined, Ai represents the scaling parameters corresponding to different electric fields to be combined, and n is the number of electric field information to be combined.

[0143] Exemplarily, three electric field information to be combined N1, N2, N3 have been determined, and the scaling coefficients A1, A2, and A3 corresponding to each electric field information to be combined have been determined by the above method. Then, the final electric field determined by the three electric field information to be combined can be:

[0144] E=N1*A1+N2*A2+N3*A3

[0145] Wherein, E represents electric field information to be combined, N1, N2, and N3 represent multiple electric field information to be combined, and A1, A2, and A3 represent scaling parameters corresponding to each electric field information to be combined.

[0146] S280, displaying the programmable electric field information on the displayed brain tissue image model.

[0147] The technical solution of the embodiment of the present invention is to determine an electric field information library of a single negative pole, wherein the electric field information library includes multiple alternative electric field information corresponding to the electrode model, each of the alternative electric field information represents an alternative configuration information and the distribution information of the simulated electric field generated by the electrode model under the reference applied voltage on the brain tissue image model; determine at least one electric field information to be combined among the multiple alternative electric field information in the electric field information library according to the electrode configuration information; determine the scaling parameters of each electric field information to be combined based on the stimulation parameter application information, and determine the program-controlled electric field information according to the electric field information to be combined and the scaling parameters. The present invention can directly retrieve the electric field information to be combined related to the electrode configuration information from the electric field information library, and combine the electric field information to be combined based on the scaling parameters to obtain the program-controlled electric field information, which greatly reduces the amount of real-time calculations and achieves the effect of quickly displaying the program-controlled electric field information of the electrode model under the electrode configuration information and the stimulation parameter application information.

[0148] The following is a further explanation of the stimulation electric field display method:

[0149] The present invention pre-calculates and stores the electric field distribution of each electrode model under different polarity configurations of a single negative pole, and combines the electric fields using the additivity and homogeneity of the electric fields, so as to quickly calculate and display the target electric field distribution of any electrode configuration.

[0150] Specifically, for the electrode model in the brain tissue imaging model corresponding to the target object, each pole is set as a negative pole, and the remaining points are set as empty poles (not set) or positive poles, and all combinations of electrode configurations are traversed. Combined with the personalized conductivity and dielectric constant of the model corresponding to the target object, and the material properties of the electrode, the electric field of a single negative pole is generated. Combined with the additivity of the electric field (the multiple negative poles of the electrode can be obtained by superimposing the simulation results of multiple single negative poles) and the homogeneity (the simulation results of different voltages of the electrode can be derived from the proportional calculation results of the simulation results of the voltage), for the electrode configuration to be displayed by the electric field, by searching and combining the pre-stored single pole electric field distribution information, and based on the linear superposition of the electric field information of different polarity configurations, the target electric field distribution is quickly generated.

[0151] Furthermore, the electric field information of a single negative pole is pre-calculated and the information library is established: for each target pole on each electrode model, the electric field distribution information under the reference voltage is calculated when the pole is negative and the other electrodes are positive or not set. The individual parameters such as conductivity, dielectric constant and electrode material properties corresponding to the model of the target object are introduced in the calculation process. The electric field distribution information is accurately calculated and stored to build the electric field information library of a single negative pole.

[0152] In view of the homogeneity of the electric field, the electric field strength under different applied voltages can be calculated by linear scaling, as follows:

[0153] E(kV)=kE(V)

[0154] Among them, E(kV) represents the electric field information after scaling, k represents the voltage scale factor (scaling parameter), E(V) represents the electric field information before scaling, and V is the reference voltage (reference applied voltage).

[0155] In the case where the target applied voltage value and the reference voltage are non-integer multiples, an interpolation method can be used to calculate the target electric field distribution to obtain the electric field under the parameters of the target applied voltage.

[0156] For the electric field superposition of multiple negative poles, based on the linear superposition characteristics of the electric field, by searching and combining the pre-calculated electric field distribution of a single negative pole, the relevant electric field distribution is quickly extracted and combined from the pre-calculated information library to obtain the target electric field distribution.

[0157] For electric field fusion and correction, the electric fields to be combined are fused and corrected into a whole, and then fused with the electrode model and brain tissue image model; the discontinuity generated during the fusion process is eliminated through an adaptive smoothing algorithm, and the continuity of the overall electric field distribution is improved while maintaining important features. The integrated electric field distribution information is displayed.

[0158] The beneficial effects of the present invention are: improving the calculation efficiency of the target electric field: by directly calling the electric field distribution information of the single negative pole pre-calculated and stored in the electric field information library, the real-time calculation amount of the target electric field is greatly reduced, and the effect of quickly calculating the electric field distribution information of any electrode configuration is achieved. The calculation accuracy of the electric field information of the single negative pole is improved: the pre-calculated electric field distribution information of the single negative pole takes into account the personalized simulation program parameters of the model of the target object (brain tissue imaging model electrode model), ensuring the calculation accuracy. The versatility of application is improved. The present invention can be applied to a variety of electrode configurations and target objects with different brain structures. The visualization display of the simulated program-controlled electric field is realized, and the rapid visualization display of the program-controlled electric field information of at least one of the electrode models under the application information of the stimulation parameters is realized, which assists the user to intuitively understand the distribution of the program-controlled electric field information generated by the electrode model under different electrode configurations and applied voltages in the brain tissue imaging model, effectively improving the user experience.

[0159] Embodiment 3

[0160] Figure 5 This is a schematic diagram of the structure of an analog program-controlled electric field display device provided in the third embodiment of the present invention. Figure 5 As shown, the device includes: a model display module 310, an electrode configuration module 320 and an electric field display module 330.

[0161] Among them, the model display module 310 is used to determine the target object and the brain tissue image model corresponding to the target object in response to the model display operation, wherein the brain tissue image model includes at least one electrode model for deep brain stimulation; the electrode configuration module 320 is used to determine the electrode configuration information and stimulation parameter application information of each electrode model in response to the electrode configuration operation, wherein the electrode model includes multiple target poles, and the electrode configuration information includes the target polarity of each target pole; the electric field display module 330 is used to determine the programmed electric field information of at least one electrode model under the electrode configuration information and the stimulation parameter application information in response to the electric field display operation, and display the programmed electric field information on the displayed brain tissue image model.

[0162] The technical solution of the embodiment of the present invention determines the target object and the brain tissue image model corresponding to the target object in response to the model display operation, wherein the brain tissue image model includes at least one electrode model for deep brain stimulation; in response to the electrode configuration operation, determines the electrode configuration information and stimulation parameter application information of each electrode model, wherein the electrode model includes multiple target poles, and the electrode configuration information includes the target polarity of each target pole; in response to the electric field display operation, determines the program-controlled electric field information of at least one electrode model under the electrode configuration information and the stimulation parameter application information, and displays the program-controlled electric field information on the displayed brain tissue image model. The present invention achieves the effect of quickly calculating and displaying the distribution of the simulated program-controlled electric field of the electrode model under any electrode configuration and applied voltage on the brain tissue image model. The present invention can effectively assist technicians in DBS electrode configuration, and has strong versatility and can be applied to target objects of any brain structure.

[0163] Optionally, the electric field display module 330 includes:

[0164] An information library determination unit, used to determine an electric field information library of a single negative pole, wherein the electric field information library includes a plurality of candidate electric field information corresponding to the electrode model, each of the candidate electric field information represents distribution information of a simulated electric field generated by any target pole in the electrode model under a reference applied voltage on the brain tissue image model;

[0165] An electric field determination unit to be combined, configured to determine at least one electric field information to be combined from the electric field information library according to the electrode configuration information;

[0166] a scaling parameter determining unit, configured to determine a scaling parameter of each of the electric field information to be combined based on the stimulation parameter application information;

[0167] The program-controlled electric field determination unit is used to determine the program-controlled electric field information according to the at least one electric field information to be combined and the corresponding scaling parameter.

[0168] Optionally, the programmable electric field determination unit is specifically used to:

[0169] For each of the electrode models, determining actual electric field information of each of the target poles in the electrode model according to at least one of the electric field information to be combined and the scaling parameter corresponding to each of the electric field information to be combined;

[0170] Determining the positional relationship of a plurality of the target poles in the electrode model;

[0171] The plurality of actual electric field information are range-union processed according to the positional relationship to obtain the program-controlled electric field information corresponding to each electrode model.

[0172] Optionally, the analog program-controlled electric field display device further includes:

[0173] an alternative electric field determination module, used for, before determining the electric field information library of the single negative pole, for each target pole of the electrode model, setting the polarity of the target pole to a negative pole, and setting the polarities of other target poles except the negative electrode to a positive pole and / or a blank pole, delivering an electric pulse to the target electrode according to a reference applied voltage, so as to obtain alternative electric field information corresponding to each target pole;

[0174] The information library construction module is used to construct the electric field information library according to the candidate electric field information corresponding to each target pole in the electrode model.

[0175] Optionally, the alternative electric field determination module includes:

[0176] a correction coefficient determination unit, configured to determine a correction coefficient associated with each target pole and the brain tissue image model, wherein the correction coefficient is associated with at least a location in the brain where the electrode is implanted into the target subject;

[0177] The alternative electric field determination unit is used to determine the alternative electric field information of each target pole according to the reference applied voltage applied to each target pole and the correction coefficient.

[0178] Optionally, the correction factor includes at least one of the conductivity, dielectric constant and electrode material parameters of the target object's brain tissue.

[0179] Optionally, the alternative electric field determination unit is specifically configured to:

[0180] Obtaining standard electric field information corresponding to each target pole according to the reference applied voltage applied to each target pole;

[0181] The standard electric field information is corrected according to the correction coefficient corresponding to each target pole to obtain the candidate electric field information corresponding to the target pole.

[0182] Optionally, the analog program-controlled electric field display device further includes:

[0183] A model simulation module, used for obtaining a simulated tissue model of the patient's brain tissue before determining the electric field information library of the single negative pole, and implanting at least one simulated electrode into the simulated tissue model to obtain a target simulated model;

[0184] The electric pulse delivery module is used to deliver electric pulses to the simulation electrodes in the target simulation model according to the reference applied voltage to obtain alternative electric field information corresponding to each target pole.

[0185] Optionally, the to-be-combined electric field determination unit is specifically used to:

[0186] Determining an electric field information search rule corresponding to the target configuration category according to the target configuration category of the electrode configuration information;

[0187] According to the electric field information search rule, at least one electric field information to be combined corresponding to the electrode configuration information is searched in the plurality of candidate electric field information in the electric field information library.

[0188] Optionally, the target configuration category includes a single negative electrode category and / or a multiple negative electrode category, and the multiple negative electrode category includes an adjacent negative electrode category and / or a non-adjacent negative electrode category.

[0189] The analog program-controlled electric field display device provided in the embodiment of the present invention can execute the stimulation electric field display method provided in any embodiment of the present invention, and has the corresponding functional modules and beneficial effects of the execution method.

[0190] Embodiment 4

[0191] Figure 6 A schematic diagram of the structure of an electronic device 10 that can be used to implement an embodiment of the present invention is shown. The electronic device is intended to represent various forms of digital computers, such as laptop computers, desktop computers, workstations, personal digital assistants, servers, blade servers, mainframe computers, and other suitable computers. The electronic device can also represent various forms of mobile devices, such as personal digital processing, cellular phones, smart phones, wearable devices (such as helmets, glasses, watches, etc.) and other similar computing devices. The components shown herein, their connections and relationships, and their functions are merely examples and are not intended to limit the implementation of the present invention described and / or required herein.

[0192] like Figure 6As shown, the electronic device 10 includes at least one processor 11, and a memory connected to the at least one processor 11, such as a read-only memory (ROM) 12, a random access memory (RAM) 13, etc., wherein the memory stores a computer program that can be executed by at least one processor, and the processor 11 can perform various appropriate actions and processes according to the computer program stored in the read-only memory (ROM) 12 or the computer program loaded from the storage unit 18 to the random access memory (RAM) 13. In the RAM 13, various programs and data required for the operation of the electronic device 10 can also be stored. The processor 11, the ROM 12, and the RAM 13 are connected to each other through a bus 14. An input / output (I / O) interface 15 is also connected to the bus 14.

[0193] A number of components in the electronic device 10 are connected to the I / O interface 15, including: an input unit 16, such as a keyboard, a mouse, etc.; an output unit 17, such as various types of displays, speakers, etc.; a storage unit 18, such as a disk, an optical disk, etc.; and a communication unit 19, such as a network card, a modem, a wireless communication transceiver, etc. The communication unit 19 allows the electronic device 10 to exchange information / data with other devices through a computer network such as the Internet and / or various telecommunication networks.

[0194] The processor 11 may be a variety of general and / or dedicated processing components with processing and computing capabilities. Some examples of the processor 11 include, but are not limited to, a central processing unit (CPU), a graphics processing unit (GPU), various dedicated artificial intelligence (AI) computing chips, various processors running machine learning model algorithms, a digital signal processor (DSP), and any appropriate processor, controller, microcontroller, etc. The processor 11 performs the various methods and processes described above, such as the stimulation electric field display method.

[0195] In some embodiments, the stimulation electric field display method can be implemented as a computer program, which is tangibly contained in a computer-readable storage medium, such as a storage unit 18. In some embodiments, part or all of the computer program can be loaded and / or installed on the electronic device 10 via the ROM 12 and / or the communication unit 19. When the computer program is loaded into the RAM 13 and executed by the processor 11, one or more steps of the stimulation electric field display method described above can be performed. Alternatively, in other embodiments, the processor 11 can be configured to perform the stimulation electric field display method in any other appropriate manner (for example, by means of firmware).

[0196] Various implementations of the systems and techniques described above herein can be implemented in digital electronic circuit systems, integrated circuit systems, field programmable gate arrays (FPGAs), application specific integrated circuits (ASICs), application specific standard products (ASSPs), systems on chips (SOCs), load programmable logic devices (CPLDs), computer hardware, firmware, software, and / or combinations thereof. These various implementations can include: being implemented in one or more computer programs that can be executed and / or interpreted on a programmable system including at least one programmable processor, which can be a special purpose or general purpose programmable processor that can receive data and instructions from a storage system, at least one input device, and at least one output device, and transmit data and instructions to the storage system, the at least one input device, and the at least one output device.

[0197] Computer programs for implementing the methods of the present invention may be written in any combination of one or more programming languages. These computer programs may be provided to a processor of a general-purpose computer, a special-purpose computer, or other programmable data processing device, so that when the computer program is executed by the processor, the functions / operations specified in the flow chart and / or block diagram are implemented. The computer program may be executed entirely on the machine, partially on the machine, partially on the machine and partially on a remote machine as a stand-alone software package, or entirely on a remote machine or server.

[0198] In the context of the present invention, a computer-readable storage medium may be a tangible medium that may contain or store a computer program for use by or in combination with an instruction execution system, device or equipment. A computer-readable storage medium may include, but is not limited to, electronic, magnetic, optical, electromagnetic, infrared, or semiconductor systems, devices or equipment, or any suitable combination of the foregoing. Alternatively, a computer-readable storage medium may be a machine-readable signal medium. A more specific example of a machine-readable storage medium may include an electrical connection based on one or more lines, a portable computer disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing.

[0199] To provide interaction with a user, the systems and techniques described herein may be implemented on an electronic device having: a display device (e.g., a CRT (cathode ray tube) or LCD (liquid crystal display) monitor) for displaying information to the user; and a keyboard and a pointing device (e.g., a mouse or trackball) through which the user can provide input to the electronic device. Other types of devices may also be used to provide interaction with the user; for example, the feedback provided to the user may be any form of sensory feedback (e.g., visual feedback, auditory feedback, or tactile feedback); and input from the user may be received in any form (including acoustic input, voice input, or tactile input).

[0200] The systems and techniques described herein may be implemented in a computing system that includes backend components (e.g., as a data server), or a computing system that includes middleware components (e.g., an application server), or a computing system that includes frontend components (e.g., a user computer with a graphical user interface or a web browser through which a user can interact with implementations of the systems and techniques described herein), or a computing system that includes any combination of such backend components, middleware components, or frontend components. The components of the system may be interconnected by any form or medium of digital data communication (e.g., a communication network). Examples of communication networks include: a local area network (LAN), a wide area network (WAN), a blockchain network, and the Internet.

[0201] A computing system may include a client and a server. The client and the server are generally remote from each other and usually interact through a communication network. The client and server relationship is generated by computer programs running on the corresponding computers and having a client-server relationship with each other. The server may be a cloud server, also known as a cloud computing server or cloud host, which is a host product in the cloud computing service system to solve the defects of difficult management and weak business scalability in traditional physical hosts and VPS services.

[0202] It should be understood that the various forms of processes shown above can be used to reorder, add or delete steps. For example, the steps described in the present invention can be executed in parallel, sequentially or in different orders, as long as the desired results of the technical solution of the present invention can be achieved, and this document does not limit this.

[0203] The above specific implementations do not constitute a limitation on the protection scope of the present invention. It should be understood by those skilled in the art that various modifications, combinations, sub-combinations and substitutions can be made according to design requirements and other factors. Any modification, equivalent substitution and improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A stimulating electric field display method, characterized in that: include: In response to the model display operation, determining a target object and a brain tissue image model corresponding to the target object, wherein the brain tissue image model includes at least one electrode model for deep brain stimulation; In response to the electrode configuration operation, determining electrode configuration information and stimulation parameter application information of each of the electrode models, wherein the electrode model includes a plurality of target poles, and the electrode configuration information includes a target polarity of each of the target poles; In response to the electric field display operation, the programmed electric field information of at least one of the electrode models under the electrode configuration information and the stimulation parameter application information is determined, and the programmed electric field information is displayed on the displayed brain tissue image model.

2. The method according to claim 1, characterized in that The determining of the program-controlled electric field information of at least one of the electrode models under the electrode configuration information and the stimulation parameter application information comprises: Determine an electric field information library of a single negative pole, wherein the electric field information library includes a plurality of candidate electric field information corresponding to the electrode model, each candidate electric field information represents the distribution information of a simulated electric field generated by any target pole in the electrode model under a reference applied voltage on the brain tissue image model; Determine at least one electric field information to be combined from the electric field information library according to the electrode configuration information; Determine a scaling parameter of each of the electric field information to be combined based on the stimulation parameter application information; The program-controlled electric field information is determined according to the at least one electric field information to be combined and the corresponding scaling parameter.

3. The method according to claim 2, characterized in that The determining the program-controlled electric field information according to at least one of the electric field information to be combined and the corresponding scaling parameter includes: For each of the electrode models, determining actual electric field information of each of the target poles in the electrode model according to at least one of the electric field information to be combined and the scaling parameter corresponding to each of the electric field information to be combined; Determining the positional relationship of a plurality of the target poles in the electrode model; The plurality of actual electric field information are range-union processed according to the positional relationship to obtain the program-controlled electric field information corresponding to each electrode model.

4. The method according to claim 2, characterized in that: Before determining the electric field information base of the single negative pole, the method further includes: For each target pole of the electrode model, the polarity of the target pole is set to a negative pole, and the polarities of other target poles except the negative electrode are set to a positive pole and / or a blank pole, and an electric pulse is delivered to the target electrode according to a reference applied voltage to obtain alternative electric field information corresponding to each target pole; The electric field information library is constructed according to the candidate electric field information corresponding to each target pole in the electrode model.

5. The method according to claim 4, characterized in that The step of delivering electric pulses to the target electrodes according to the reference applied voltage to obtain candidate electric field information corresponding to each target pole includes: Determining a correction coefficient associated with each target pole and the brain tissue image model, wherein the correction coefficient is at least associated with a location in the brain where the electrode is implanted into the target subject; The candidate electric field information of each target pole is determined according to the reference applied voltage applied to each target pole and the correction coefficient.

6. The method according to claim 5, characterized in that The correction factor includes at least one of the conductivity, dielectric constant and electrode material parameters of the target object's brain tissue.

7. The method according to claim 5, characterized in that The determining the candidate electric field information of each target pole according to the reference applied voltage applied to each target pole and the correction coefficient comprises: Obtaining standard electric field information corresponding to each target pole according to the reference applied voltage applied to each target pole; The standard electric field information is corrected according to the correction coefficient corresponding to each target pole to obtain the candidate electric field information corresponding to the target pole.

8. The method according to claim 2, characterized in that: Before determining the electric field information base of the single negative pole, the method further includes: Acquire a simulated tissue model of a patient's brain tissue, and implant at least one simulated electrode into the simulated tissue model to obtain a target simulated model; Electric pulses are delivered to the simulation electrodes in the target simulation model according to a reference applied voltage to obtain candidate electric field information corresponding to each target pole.

9. The method according to claim 2, characterized in that: The step of determining at least one piece of electric field information to be combined from the electric field information library according to the electrode configuration information comprises: Determining an electric field information search rule corresponding to the target configuration category according to the target configuration category of the electrode configuration information; According to the electric field information search rule, at least one electric field information to be combined corresponding to the electrode configuration information is searched in the plurality of candidate electric field information in the electric field information library.

10. The method according to claim 9, characterized in that The target configuration category includes a single negative electrode category and / or a multiple negative electrode category, and the multiple negative electrode category includes an adjacent negative electrode category and / or a non-adjacent negative electrode category.

11. An analog program-controlled electric field display device, characterized in that: include: A model display module, configured to determine a target object and a brain tissue image model corresponding to the target object in response to a model display operation, wherein the brain tissue image model includes at least one electrode model for deep brain stimulation; An electrode configuration module, configured to determine electrode configuration information and stimulation parameter application information of each of the electrode models in response to an electrode configuration operation, wherein the electrode model includes a plurality of target poles, and the electrode configuration information includes a target polarity of each of the target poles; The electric field display module is used to determine the programmed electric field information of at least one of the electrode models under the electrode configuration information and the stimulation parameter application information in response to the electric field display operation, and display the programmed electric field information on the displayed brain tissue image model.

12. A neural stimulation system, characterized in that The system comprises: Implantable medical devices, which are intended to be implanted in a patient’s body; a stimulation electrode, which is used to be implanted in a target nucleus of the patient's brain and is electrically connected to the implantable medical device; A program-controlled device, arranged at the doctor's end, for program-controlled connection with the implantable medical device and sending program-controlled instructions to the implantable medical device so that the implantable medical device delivers electrical pulses to the stimulation electrode; The program-controlled device at least includes a program-controlled interface, a display interface and a processor; The program control interface is used to receive the doctor's program control operation; The processor responds to the input instruction received by the program control interface at least including the electric field display, executes the method according to any one of claims 1 to 10, and obtains the electric field display information corresponding to the stimulation parameters input by the doctor; The display interface is used to display the patient's brain tissue image model and the electric field model corresponding to the electric field display information.

13. An electronic device, characterized in that: The electronic device comprises: at least one processor; and a memory communicatively connected to the at least one processor; wherein, The memory stores a computer program executable by the at least one processor, and the computer program is executed by the at least one processor so that the at least one processor can perform the stimulating electric field display method according to any one of claims 1 to 10.

14. A computer-readable storage medium, characterized in that: The computer-readable storage medium stores computer instructions, and the computer instructions are used to enable a processor to implement the stimulation electric field display method according to any one of claims 1 to 10 when executed.

15. A computer program product, characterized in that The computer program product comprises a computer program, which, when executed by a processor, implements the stimulation electric field display method according to any one of claims 1 to 10.

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