A deep brain stimulation device capable of implementing an explosive stimulation pattern

Abstract

The present application relates to a kind of brain deep electric stimulation equipment capable of realizing burst stimulation mode, the electric stimulation equipment includes brain deep stimulation unit and brain deep stimulation electrode, and they are connected by in-vivo lead wire.Wherein, brain deep stimulation unit is configured to be able to make brain deep stimulation electrode at adjustable stimulation parameter burst stimulation mode to implement the deep brain stimulation neuroregulation of target target point.Therein, the stimulation signal of burst stimulation mode can be adaptively adjusted according to the different electrophysiological characteristics of target target point one or more of group frequency, intra-group frequency and the number of sine waves in single stimulation period.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a deep brain stimulation device capable of achieving a burst stimulation mode. Background Technology

[0002] In recent years, neuromodulation technology has become an important treatment for neurological diseases. As a representative technology in the field of neuromodulation, deep brain stimulation (DBS) applies electrical stimulation to specific brain regions through precisely implanted electrodes. It has shown significant efficacy in the clinical treatment of movement disorders (such as Parkinson's disease and dystonia), mental illnesses (such as treatment-resistant depression and obsessive-compulsive disorder), and epilepsy. It can not only effectively improve clinical symptoms but also significantly improve patients' quality of life.

[0003] Currently, deep brain stimulation (DBS) primarily employs two modulation modes: open-loop and closed-loop. Open-loop systems use preset, fixed stimulation parameters and cannot respond in real-time to dynamic changes in neural activity. While closed-loop systems can dynamically adjust parameters based on neural electrical signals (such as local field potentials), they still face technical bottlenecks in real-time computational capabilities, mode-switching efficiency, and long-term stability. These limitations directly affect the precision and clinical applicability of DBS therapy. Although traditional continuous high-frequency electrical stimulation can effectively modulate abnormal neural circuits, clinical practice has revealed that long-term stimulation of neural nuclei may lead to potential neuronal damage. Therefore, developing an innovative neuromodulation device capable of precisely modulating brain circuit disease networks while minimizing side effects has become a crucial scientific challenge and clinical need in the field of neuromodulation.

[0004] This invention provides a deep brain stimulation (DBS) device capable of achieving a burst stimulation mode. The burst stimulation mode employs a short-duration, high-frequency pulse train electrical stimulation paradigm, which can highly simulate the characteristics of physiological neural discharges. Currently, although this stimulation mode has been applied in non-invasive neuromodulation techniques such as transcranial magnetic stimulation (TMS), no devices with the same technical characteristics have been reported in the field of implantable DBS. In previous clinical studies based on intracranial stereotactic electroencephalography (EEG), the invention team has preliminarily discovered that burst stimulation can achieve the same desynchronization effect as traditional stimulation while exhibiting more durable efficacy maintenance and lower tolerance risk. The research results have been published in a classic neurology journal. Brain superior.

[0005] This invention fills the gap in the application of burst stimulation technology in the field of deep brain stimulation (DBS) and has the following outstanding advantages: (1) It is the first DBS device to develop a burst stimulation mode that conforms to physiological characteristics; (2) The device can support burst stimulation based on the principle of synaptic plasticity, promoting the functional remodeling of abnormal neural circuits; (3) The device adopts a programmable multi-parameter design to support the optimization of individualized treatment plans. This technology provides a safer and more effective solution for DBS treatment, with significant clinical application value and broad market prospects.

[0006] Furthermore, on the one hand, there are differences in understanding among those skilled in the art; on the other hand, the applicant studied a large number of documents and patents when making this invention, but due to space limitations, not all details and contents were listed in detail. However, this does not mean that the present invention does not possess the features of these prior art. On the contrary, the present invention already possesses all the features of the prior art, and the applicant reserves the right to add relevant prior art to the background art. Summary of the Invention

[0007] Currently, most clinically used deep brain stimulation (DBS) modes involve continuous high-frequency stimulation, such as a stimulation frequency of 130–180 Hz, a pulse width of 60–90 μs, and a stimulation intensity of 1–4 mA. However, there is still room for improvement in these stimulation parameters and modes.

[0008] This invention relates to a deep brain stimulation (DBS) device capable of achieving a burst-like stimulation mode, comprising DBS electrodes implanted in the brain and a connected DBS unit. The DBS unit outputs burst-like stimulation pulses to the target area via the DBS electrodes. This signal consists of alternating stimulation periods and interval periods. During the stimulation period, multiple sinusoidal pulses are continuously emitted at an intra-group frequency, and pulse output ceases during the interval period. After multidisciplinary consultation and evaluation by neurology, neurosurgery, radiology, and electrophysiology experts, the stimulation electrodes are precisely implanted into the target area of ​​the patient's brain along a predetermined path according to an individualized treatment plan. The core innovation of this invention lies in its burst-like stimulation mode. In this mode, various stimulation parameters (including pulse frequency, current intensity, duration, etc.) can be dynamically adjusted according to the physiological characteristics and treatment needs of different brain target areas, achieving precise and individualized neuromodulation therapy. Through this programmable burst-like stimulation mode, the system can provide optimized combinations of treatment parameters for different neural circuits and pathological states.

[0009] In particular, the deep brain stimulation device of this invention introduces a burst stimulation mode. This burst stimulation mode, with its unique pulse train delivery method, can improve the specificity and effectiveness of stimulation while reducing energy consumption. By adjusting the stimulation parameters, doctors can provide personalized treatment for different patients, thereby achieving the best therapeutic effect. Specifically, the burst stimulation signal generated by the deep brain stimulation unit has adjustable group frequency and intra-group frequency. The burst stimulation signal can be adaptively adjusted by the deep brain stimulation unit according to the different electrophysiological characteristics of the target point, including one or more of the group frequency, intra-group frequency, and the number of sine waves within a single stimulation period.

[0010] According to a preferred embodiment, the deep brain stimulation (DBS) unit is equipped with a controller. After the medical image navigation system completes target localization, the controller receives target location information and diagnostic type, and selects appropriate burst stimulation parameters for the patient based on the clinician's judgment. The controller can adjust the stimulation parameters in the burst stimulation mode according to preset rules. The DBS unit can transmit the adjusted stimulation parameters as stimulation signals to the DBS electrodes via a stimulation output port using its configured signal generator. These stimulation parameters include group frequency, intra-group frequency, number of sinuses within a group, stimulation duration, rest duration, and number of cycles. The introduction of a wireless transmission module enables the DBS unit to receive relevant information about the target point in real time or on demand, including key data such as location, size, shape, and relationship with surrounding tissues. This real-time data exchange ensures the accuracy and dynamic adjustment capability of the treatment process. The controller allows adjustment of stimulation parameters such as group frequency, intra-group frequency, number of sinuses within a group, stimulation duration, rest duration, and number of cycles through a series of preset rules. This adjustment mechanism not only improves the precision of treatment, but also reduces discomfort or ineffective stimulation that may result from fixed parameter settings, thereby optimizing treatment effectiveness and patient comfort.

[0011] According to a preferred embodiment, the controller is configured with a channel adjustment module, a frequency adjustment module, and an intensity adjustment module. The channel adjustment module activates the stimulation channel of the deep brain stimulation electrode corresponding to the site. The frequency adjustment module is configured to adjust the group frequency, intra-group frequency, and intra-group sine wave number in the burst stimulation mode. The intensity adjustment module is configured to adjust the current intensity in the burst stimulation mode. Different frequency adjustments will have different effects on the activation mode of neurons. The frequency adjustment module can improve the therapeutic effect by flexibly adjusting the rhythm and mode of stimulation. Furthermore, the intensity adjustment module, by adjusting the current intensity in the burst stimulation mode, can dynamically adjust the stimulation intensity according to the patient's tolerance and response.

[0012] According to a preferred embodiment, the deep brain stimulation unit can generate burst stimulation signals between two contacts of the deep brain stimulation electrodes. By activating the deep brain stimulation electrodes in a burst stimulation mode, electrical stimulation is applied to the target site. The burst stimulation mode pulses are cyclically delivered at time intervals. The burst stimulation mode is configured as an intermittent stimulation mode including intervals and stimulation periods, where the sum of the stimulation duration of one stimulation period and the rest duration of one interval is the total duration of one cycle. By introducing the concepts of intervals and stimulation periods, the burst stimulation mode achieves more precise and dynamic control of neural tissue. Electrical stimulation during the stimulation period can directly act on the target neural tissue, triggering a series of physiological and biochemical responses, thereby regulating the function of the nervous system. The existence of the interval allows the neural tissue to rest and recover to a certain extent after stimulation, avoiding fatigue or reduced adaptability that may result from continuous stimulation. This alternation of stimulation and rest allows the burst stimulation mode to more effectively stimulate the response potential of the nervous system while reducing unnecessary energy consumption and potential side effects.

[0013] Stimulation parameters include group frequency and intra-group frequency. Group frequency refers to the frequency within a stimulation period, while intra-group frequency refers to the frequency of the sine wave within a stimulation period. On one hand, setting the group frequency allows for macroscopic adjustment of the stimulation frequency throughout the entire stimulation period. By adjusting the group frequency, the total number of stimulation pulses per unit time can be controlled, thereby affecting the excitability and response intensity of neural tissue. On the other hand, the introduction of intra-group frequency enables fine-grained control of the internal characteristics of each pulse within the stimulation period. Intra-group frequency determines the waveform and frequency characteristics of the pulse. By adjusting the intra-group frequency, parameters such as the pulse shape, width, and duration can be changed, thus affecting the specific effect of the stimulation signal on neural tissue (different pulse widths and current intensities have different degrees of influence on cortical evoked sites; see [reference needed]). Figure 5 In this mode, burst stimulation pulses are delivered cyclically at time intervals. Compared to traditional continuous pulse stimulation, the burst stimulation mode is characterized by pulses being delivered in clusters, with pulses within each cluster closely connected, while there are time intervals between clusters. This pulse delivery method better matches the natural firing rhythm of neurons, thus showing superior efficacy in treating neurological circuit disorders. Simultaneously, this energy-saving characteristic helps extend the lifespan of the device, reduces the frequency of battery replacements, and thereby lowers the overall cost of treatment. This invention provides an innovative burst stimulation mode for optimizing the selection of neuromodulation parameters, achieving highly efficient and energy-saving neuromodulation through intermittent pulse delivery.

[0014] This system supports multiple programmable burst stimulation modes, including theta-burst stimulation (TBS) and adjustable multi-frequency stimulation. TBS is divided into continuous mode (cTBS) and intermittent mode (iTBS). According to literature, based on the principle of synaptic plasticity, cTBS can induce long-term inhibition to reduce cortical excitability, while iTBS can induce long-term enhancement to increase excitability. The system also supports custom configuration of the "X / YHz" parameter, allowing precise setting of the number of pulse clusters per minute and the intra-cluster frequency (e.g., "3 / 50Hz" indicates 3 clusters of 50Hz pulses per minute). Technically, an FPGA hardware timer ensures microsecond-level timing accuracy, a dynamic impedance matching circuit maintains current stability, and real-time charge density monitoring ensures treatment safety. This intelligent burst stimulation scheme retains the efficacy of traditional methods while significantly improving energy efficiency and safety, providing a more optimized solution for neuromodulation therapy.

[0015] According to a preferred embodiment, the pulse parameters of the burst stimulation mode are set by the deep brain stimulation unit to emit one or more clusters within one minute, and when emitting multiple clusters, the frequencies between different clusters can be freely adjusted. The variable configuration of frequencies between different clusters can simulate the natural oscillatory characteristics of biological neural pulses, while the cluster firing control within one minute conforms to the metabolic cycle characteristics of deep brain nuclei, avoiding the decline in stimulation efficacy due to energy depletion.

[0016] According to a preferred embodiment, the burst stimulation mode is configured as an intermittent stimulation mode comprising intervals and stimulation periods, wherein the sum of the stimulation duration of one stimulation period and the rest duration of one interval is the total duration of one cycle; the group frequency included in the stimulation parameters refers to the frequency within a stimulation period, and the intra-group frequency included in the stimulation parameters refers to the frequency of the sine wave to which a stimulation period belongs. The synergistic effect of group frequency and intra-group frequency can reset the neurophysiological state through periodic silent intervals, maintaining the effective transmission of stimulation signals. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the deep brain stimulation unit of the present invention installed in a patient's body; Figure 2 This is a hardware topology diagram of the deep brain stimulation unit of the present invention; Figure 3 This is a schematic diagram illustrating the stimulation modes achievable by the device of the present invention; Figure 4 The present invention describes the modes and stimulation effects of the device implementing traditional continuous high-frequency stimulation and explosive stimulation respectively. Figure 5 This is a comparison diagram of the changes in subcortical evoked potentials with different current intensities and pulse widths when the deep brain stimulation unit of the present invention implements a burst stimulation mode. Figure 6 This is a schematic diagram of the deep brain stimulation unit of the present invention setting an intermittent stimulation mode; Figure 7 This is a schematic diagram of the operation process of the deep brain stimulation device of the present invention.

[0018] List of reference numerals 100: Deep brain stimulation electrode; 200: Deep brain stimulation unit; 210: Controller; 211: Channel adjustment module; 212: Frequency adjustment module; 213: Intensity adjustment module; 220: Signal generator; 221: Electrical pulse generation module; 230: Stimulation output port; 240: Battery module. Detailed Implementation

[0019] The following is a detailed explanation with reference to the accompanying drawings.

[0020] This invention proposes a deep brain stimulation (DBS) device capable of achieving a burst stimulation mode for electrical stimulation of target points in a patient's brain. This DBS device allows for the setting and adjustment of different stimulation parameters within the burst stimulation mode, which offers advantages over traditional electrical stimulation modes, including greater energy efficiency and less damage.

[0021] Preferably, the deep brain stimulation unit 200 of the present invention can apply a burst stimulation mode to the deep brain stimulation electrode 100 implanted at the target site for deep brain stimulation therapy.

[0022] To explore a stimulation mode that is both energy-efficient and intelligent, this invention designs a burst stimulation mode. The main characteristic of this burst stimulation mode is the delivery of pulse clusters within a short period, with each pulse cluster consisting of consecutive stimulation cycles. This pulse delivery method better aligns with the natural firing rhythm of neurons. Figure 4 This study compares the inhibitory effects of burst stimulation and sustained high-frequency stimulation on epileptic discharges (cited from Cheng Y, Wang D, Zhang X, Jin G, Wu D, Wang Q, Du J, Qi L, Xu C, Qiao Z, Wang X, Ge J, Wang S, Yan H, Wang X, Zhang H, Yu T, Wang Y, Yeh FC, Zhao G, Ren L. Structural network-specific effect of extreme capsule stimulation for drug-resistant focal epilepsy. Brain. 2025 Mar 21:). According to... Figure 4It can be observed that burst stimulation mode can not only achieve a similar modulation effect to the continuous high-frequency stimulation currently used in clinical practice, but also achieve this effect at a lower stimulation current intensity, giving burst stimulation mode a dual advantage: on the one hand, it reduces the risk of neuronal electrical stimulation damage, and on the other hand, it significantly reduces energy consumption, which can improve the endurance of the stimulation system.

[0023] The deep brain stimulation unit 200 of the present invention can use a target point as the stimulation target, and the deep brain stimulation unit 200 can apply a burst stimulation pattern. For example... Figure 3 As shown, it includes theta-burst stimulation and 1Hz-burst stimulation. Theta-burst stimulation can be divided into continuous theta burst stimulation (cTBS) and intermittent theta burst stimulation (iTBS) depending on whether there is an interval during the stimulation process.

[0024] Continuous Tissue Stimulation (cTBS): The commonly used cTBS protocol consists of short, repetitive high-frequency (50Hz) pulses at 5Hz (200ms intervals), without interruption, for a total of 600 pulses and a total duration of 40 seconds. By stimulating the cerebral cortex, cTBS can induce long-term depression (LTD) effects, thereby reducing cortical excitability.

[0025] Intermittent Twitch Stimulation (iTBS): The commonly used iTBS protocol involves delivering a 2-second stimulus followed by an 8-second pause, repeated 20 times for a total of 600 pulses and a total duration of 190 seconds. By stimulating the cerebral cortex, iTBS can induce long-term potentiation (LTP), thereby increasing cortical excitability.

[0026] 1Hz-burst stimulation: The frequency of the burst stimulation mode of the present invention can be 1 / 50Hz, 1 / 100Hz, 1 / 150Hz, 1 / 175Hz, or 1 / 200Hz. This represents the emission of one burst of pulses per minute, with the frequency within the burst being 50Hz, 100Hz, 150Hz, 175Hz, or 200Hz. Preferably, the burst stimulation mode of the present invention can be freely set to emit any burst within one minute, not just one burst, and the frequency within the burst can also be freely adjusted. For example, "1 / 50Hz" means that the pulses cycle on and off at 0.8-second intervals, and the internal frequency of the burst stimulation mode is 50Hz; "1 / 200Hz" means that the pulses cycle on and off at 0.8-second intervals, and the internal frequency of the burst stimulation mode is 200Hz.

[0027] Physicians can adjust the burst stimulation pattern based on the patient's response and treatment needs, reducing energy consumption while maintaining the therapeutic effect.

[0028] Preferably, such as Figure 1 , Figure 2 As shown, the deep brain stimulation unit 200 may include a wireless transmission module, a signal generator 220, a controller 210, a stimulation output port 230, and a battery module 240.

[0029] Preferably, the controller 210 is equipped with a channel adjustment module 211, a frequency adjustment module 212, and an intensity adjustment module 213. The channel adjustment module 211 is configured to activate the stimulation channel of the deep brain stimulation electrode 100 corresponding to a predetermined specific stimulation site. The frequency adjustment module 212 is configured to adjust the group frequency, intra-group frequency, and intra-group sine wave number in the burst stimulation mode. The intensity adjustment module 213 is configured to adjust the current intensity in the burst stimulation mode.

[0030] Preferably, such as Figure 7 As shown, the controller 210 is equipped with a channel adjustment module 211, a frequency adjustment module 212, and an intensity adjustment module 213. These modules are tightly connected in hardware structure and function to achieve precise control of deep brain stimulation. The main function of the channel adjustment module 211 is to select and activate the stimulation channel of the deep brain stimulation electrode 100 corresponding to a pre-determined specific stimulation site. In addition, the channel adjustment module 211 also outputs activation signals to the frequency adjustment module 212 and the intensity adjustment module 213 to enhance the stimulation effect and achieve personalized modulation. The frequency adjustment module 212 is responsible for adjusting the group frequency, intra-group frequency, and intra-group sine wave number in the burst stimulation mode. This module sets the frequency of the stimulation group according to the instructions of the controller 210 to optimize the stimulation effect and adaptability. It also dynamically adjusts the stimulation frequency of each electrode within the group to ensure the coordination and effectiveness between electrodes, while adjusting the number of sine waves within the group to make the treatment more flexible and personalized. The intensity adjustment module 213 functions to adjust the current intensity in burst stimulation mode. Specifically, it precisely adjusts the stimulation current intensity based on patient feedback and treatment needs to adapt to different clinical scenarios. Simultaneously, this module monitors and responds to changes in the patient's physiological state, rapidly adjusting the current intensity to improve patient comfort and acceptance, and stores historical treatment parameters and patient feedback to support future treatment optimization.

[0031] Preferably, to improve the physiological adaptability of regulation, the system introduces a symptom evolution trend prediction mechanism. All regulation processes are displayed through a visual interface showing the correlation between parameter adjustment trajectory and symptom relief curve. Doctors can manually intervene to adjust the weight allocation of different parameters. For example, in the acute treatment period, priority is given to ensuring efficacy, and in the recovery period, comfort optimization is emphasized, forming a dual guarantee system of "automatic response - manual calibration".

[0032] Preferably, upon receiving information related to the target point, the controller 210 of the deep brain stimulation unit 200 activates a preset algorithm program. This program integrates rich clinical data and experimental research results, automatically analyzes target characteristics, and intelligently adjusts various parameters of the burst stimulation mode based on factors such as the patient's specific condition. These parameters are not limited to group frequency, intra-group frequency, and number of intra-group sine waves, but also include stimulation duration, rest duration, and number of cycles, aiming to achieve personalized and precise treatment effects.

[0033] Preferably, the controller 210 dynamically adjusts the group frequency within the range of 1-40Hz based on factors such as the depth of the target point and the safe distance from nearby important structures. This ensures that the stimulation effectively covers the target area while avoiding unnecessary interference with surrounding brain tissue. Simultaneously, the group frequency can be flexibly set within a wide range of 50-5000Hz, allowing the generation of high-frequency sine waves. When these high-frequency waves combine into burst pulses, they can simulate natural neural signals and promote the rebalancing of the neural network. Preferably, the controller 210 also finely adjusts the number of sine waves (1-20) within the group based on the treatment goals (such as reducing tremor, improving bradykinesia, etc.) and the patient's immediate feedback to optimize the stimulation effect. Figure 6 As shown, the stimulation duration and rest duration are set based on the physiological effect of the "pulse-rest" cycle, aiming to promote neural plasticity changes through intermittent stimulation mode, while avoiding adaptation and tolerance problems that may be caused by long-term continuous stimulation.

[0034] Preferably, the adjusted stimulation parameters are converted into precise electrical signals by the signal generator 220 and transmitted to the deep brain stimulation electrodes 100 through the stimulation output port 230. These electrodes are precisely implanted into the target site, and a pulse sequence with specific time intervals is generated between the two contacts according to the set burst stimulation mode, providing precise electrical stimulation to the target site. This stimulation mode can not only effectively relieve the patient's symptoms, but also has a low risk of side effects, providing an innovative and effective means for the treatment of neurodegenerative diseases.

[0035] In the implementation of the intermittent stimulation mode, each treatment cycle consists of alternating stimulation and interval periods. The duration of the stimulation period is dynamically set according to the response characteristics of the target neural pathway. During this period, the deep brain stimulation electrode 100 continuously delivers multiple sinusoidal pulses at the intra-group frequency, forming a dense pulse sequence. During the interval period, pulse output is completely stopped, providing time for neural tissue to recover. The total duration of a single complete cycle is determined by the sum of the stimulation and interval times, and this time parameter is adaptively adjusted according to different treatment stages. The group frequency setting reflects the frequency of stimulation periods per unit time and is used to control the overall treatment rhythm; the intra-group frequency determines the firing rate of each pulse within a single stimulation period, directly affecting the synchronous activation effect of neurons. By rationally configuring the stimulation / interval period duration ratio and the intra-group frequency parameter, the excitatory balance of neural modulation can be optimized while reducing energy consumption.

[0036] It should be noted that the specific embodiments described above are exemplary. Those skilled in the art can devise various solutions inspired by the disclosure of this invention, and these solutions all fall within the scope of this invention and its protection. Those skilled in the art should understand that this specification and its accompanying drawings are illustrative and do not constitute a limitation on the claims. The scope of protection of this invention is defined by the claims and their equivalents. This specification contains multiple inventive concepts; phrases such as "preferredly" or "according to a preferred embodiment" indicate that the corresponding paragraph discloses an independent concept. The applicant reserves the right to file divisional applications based on each inventive concept. Throughout the text, the feature introduced by "preferredly" is only an optional mode and should not be construed as mandatory. Therefore, the applicant reserves the right to abandon or delete relevant preferred features at any time.

Claims

1. A deep brain stimulation device capable of achieving a burst-like stimulation mode, comprising a deep brain stimulation electrode (100) implanted in the brain and a deep brain stimulation unit (200) connected thereto, characterized in that, The deep brain stimulation unit (200) can output burst stimulation signals to the target point through the deep brain stimulation electrode (100). The signal consists of alternating stimulation periods and interval periods. During the stimulation period, multiple sinusoidal pulses are continuously emitted at the group frequency, and during the interval period, the pulse output stops. The burst stimulation signal generated by the deep brain stimulation unit (200) has an adjustable group frequency and intra-group frequency. The burst stimulation signal can be adaptively adjusted by the deep brain stimulation unit (200) according to the different electrophysiological characteristics of the target point, including one or more of the group frequency, intra-group frequency, and the number of sine waves in a single stimulation period. The deep brain stimulation unit (200) is equipped with a controller (210). After the medical image navigation system completes the target location, the controller (210) receives the target location information and diagnosis type, and provides the patient with the corresponding burst stimulation parameter selection based on the clinician's judgment. The stimulation parameters include group frequency, intra-group frequency, number of intra-group sine waves, current intensity, stimulation duration, rest duration and number of cycles. The deep brain stimulation unit (200) converts the stimulation parameters into stimulation signals through a signal generator (220) and transmits them to the deep brain stimulation electrode (100) through the output port. The pulse parameters of the burst stimulation mode are set by the deep brain stimulation unit (200) to be able to emit one or more clusters within one minute, and when emitting multiple clusters, the frequency between different clusters can be freely adjusted. The burst stimulation mode is configured as an intermittent stimulation mode including intervals and stimulation periods, wherein the sum of the stimulation duration of a stimulation period and the rest duration of an interval is the total duration of one cycle; the group frequency included in the stimulation parameters refers to the frequency within a stimulation period, and the intra-group frequency included in the stimulation parameters refers to the frequency of the sine wave to which a stimulation period belongs. The controller (210) of the deep brain stimulation unit (200) is configured to: set the group frequency dynamic adjustment range to 1~40Hz, set the group frequency dynamic adjustment range to 50~5000Hz, and set the number of sine waves in a single stimulation period to 1~20.

2. The electrical stimulation device according to claim 1, characterized in that, The controller (210) is equipped with a channel adjustment module (211), a frequency adjustment module (212), and an intensity adjustment module (213). The channel adjustment module (211) is configured to enable the stimulation channel of the deep brain stimulation electrode (100) corresponding to the predetermined stimulation site. The frequency adjustment module (212) is configured to adjust the group frequency, intra-group frequency, and intra-group sine wave number in the burst stimulation mode. The intensity adjustment module (213) is configured to adjust the current intensity in the burst stimulation mode.

3. The electrical stimulation device according to claim 1, characterized in that, The deep brain stimulation unit (200) is capable of generating burst stimulation signals between two required contacts on the deep brain stimulation electrode (100), and electrically stimulating the target point by placing the deep brain stimulation electrode (100) in the burst stimulation mode, wherein the pulses of the burst stimulation mode are cyclically delivered in the form of time intervals.

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