A recombinant type IV collagen composition for repairing basement membrane and soothing and reducing redness
Through the combination of recombinant type IV collagen and repairing nonapeptide GAAGLPGPK, the damage problem of the basement membrane and endothelial barrier was solved, and the repair of the basement membrane and a significant reduction in skin redness was achieved, which improved the skin health level.
CN119925578BActive Publication Date: 2025-08-05XIAN GIANT BIOGENE TECH CO LTD
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Patent Information
- Application Number
- CN202510192782.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-20
- Publication Date
- 2025-08-05
- Estimated Expiration
- 2045-02-20
AI Technical Summary
Technical Problem
The prior art lacks efficient and targeted solutions to repair the basement membrane barrier and endothelial barrier, protect the skin from UV and oxidative stress damage, and sensitive skin problems have not been effectively alleviated.
Method used
Recombinant type IV collagen and repairing nonapeptide GAAGLPGPK are used to inhibit the phosphorylation of VE-cadherin protein, maintain the tight junction between endothelial cells, protect the endothelial barrier function, and achieve synergistic efficiency through combined use.
Benefits of technology
Significantly repair the basement membrane barrier, reduce redness and redness in the skin, improve skin health, and provide long-term soothing effects.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention provides a recombinant type IV collagen composition for repairing basement membrane and soothing and reducing redness. The inventors found that the recombinant type IV collagen described in the specification of this patent inhibits the phosphorylation of VE-cadherin protein by mediating the PKCα / PYK2 / Src signaling pathway, protects the tight junctions between endothelial cells, prevents the leakage of blood components, and reduces vascular permeability; it can also improve the dissociation of the VE-cadherin complex caused by oxidative stress and maintain the homeostasis of the endothelial barrier; therefore, it has good effects of repairing the basement membrane barrier and soothing and reducing redness. The inventors also first discovered that the repair peptide (GAAGLPGPK) has the effects of repairing the basement membrane barrier, soothing and reducing redness, and the combination of a certain proportion of the recombinant type IV collagen and the repair peptide shows synergistic effects in repairing the basement barrier and soothing and reducing redness.
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